290:
to piggyback on a virus and deprive the virus of replication material, thus reducing viral load. TIPs replicate and co-evolve with a virus, making it a treatment that solves what
Weinberger has called a âfundamental mismatchâ between viruses and treatment: viruses evolve, vaccines do not. TIPs also have the capacity to transmit along viral transmission routes, harnessing the power of virus â
289:
by creating "therapeutic interfering particles" or "TIPs". Weinberger first began testing this concept when he was in graduate school at
Berkeley studying the biophysics of HIV. As described on Weinbergerâs lab website and in a pre-print research article, TIPs are engineered deletion mutants designed
271:
Weinberger and his lab have been credited with the discovery of HIVâs intrinsic decision circuit. Their 2005 paper in Cell showed that stochastic fluctuations in gene expression, or ânoiseâ can drive cell fate decisions enabling viral latency, which is recognized as a primary barrier to HIV cure.
186:
Weinberger is currently the
William and Ute Bowes Distinguished Professor of Virology, director of the Gladstone Center for Cell Circuitry, professor of pharmaceutical chemistry, and professor of biochemistry and biophysics at Gladstone Institutes/University of California, San Francisco He is the
272:
The lab has since been able to identify similar stochastic processes in other viruses, such as a kind of herpesvirus called human cytomegalovirus, as published in a 2020 paper. Weinberger and his lab are looking for ways to target the latency reservoir of viruses as a form of treatment.
238:, the non-profit research institution associated with UCSF. Weinberger is now the director of the Gladstone UCSF Center for Cell Circuitry and Bowes Distinguished Professor, and he retains his professorships at UCSF in pharmaceutical chemistry and biochemistry and biophysics.
263:. As stated on their website, the lab uses âmathematical & experimental approaches to decode the regulatory principles viruses use to select between alternate fatesâ and develop therapeutic targets and antiviral strategies based on those principles.
897:"Joint Warfighter Medical Research Program, FY20 Military Medical Research and Development Award - Human Subjects/Sample Acquisition with Clinical Trial Option, Congressionally Directed Medical Research Programs"
1059:
1049:
800:
Tanner, Elizabeth J.; Jung, Seung-Yong; Glazier, Joshua; Thompson, Cassandra; Zhou, Yuqi; Martin, Benjamin; Son, Hye-In; Riley, James L.; Weinberger, Leor S. (2019-10-30).
354:
Weinberger, Leor (July 29, 2005). "Stochastic Gene
Expression in a Lentiviral Positive- Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity".
971:
1002:
531:
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on this novel antiviral approach 20 years in the making has been called a "highlight" of TED and received a standing ovation from the live audience.
294:â and transmitting the treatment to resource-limited and remote populations like communities in South Africa. TIP research has been supported by the
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Weinberger's work has been referred to as "part of what some scientists are calling a 'renaissance' in viral therapy" by the
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978:
802:"Discovery and Engineering of a Therapeutic Interfering Particle (TIP): a combination self-renewing antiviral"
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1039:
230:, as an assistant professor for the Department of Chemistry and Biochemistry. Afterwards, he moved to the
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Erin Allday, January 23rd, 2013. "Viruses engineered to attack themselves", San
Francisco Chronicle.
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viral latency programs, Therapeutic
Interfering Particles (TIPs), stochastic fluctuations/bet-hedging
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Weinberger holds numerous patents for inventing novel antiviral medicines. Weinberger was named a
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http://www.sfgate.com/health/article/Viruses-engineered-to-attack-themselves-4233236.php
234:(UCSF) in an associate professor in biochemistry and biophysics before transitioning to
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Innovation review panel, and his research has been widely published in
Science,
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377:
613:"Keynote Speakers â UC Berkeley Center for Computational Biology Retreat 2019"
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168:
153:
688:
432:
532:"Avant-Garde Award Program for HIV/AIDS and Substance Use Disorder Research"
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Weinberger and his lab specialize in virology, with a specific focus on
207:
in 1998. He completed his PhD in
Biophysics, with a focus on HIV, from
175:
are used for cell fate decisions. He has also pioneered the concept of
35:
368:
640:"Weinberger Lab Gladstone / University of California, San Francisco"
408:
http://www.hhmi.org/news/random-gene-expression-may-drive-hiv-hiding
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After completing his fellowship at
Princeton, Weinberger joined the
813:
295:
872:"To Fight a Virus, Get a Virus: Military Bets on Mutant Pathogen"
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777:"Transcript of "Can we create vaccines that mutate and spread?""
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Weinberger received his undergraduate degree in biophysics from
286:
161:
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circuit, which provided the first experimental evidence that
663:
Siliciano, Robert F.; Greene, Warner C. (September 2011).
179:, or âTIPsâ, which are resistance-proof antivirals. His
722:"Herpesviruses Hedge Their Bets to Optimize Survival"
129:
115:
81:
73:
53:
43:
28:
21:
530:Abuse, National Institute on Drug (2020-06-23).
406:Howard Hughes Medical Institute, July 29, 2005.
1050:University of California, San Francisco faculty
475:"In the time of COVID-19, TEDMED still thrills"
574:http://commonfund.nih.gov/pioneer/Recipients13
455:Can we create vaccines that mutate and spread?
318:in 2011, and a Keck Awardee. He served on the
285:, Weinberger has pioneered research to combat
211:in 2004. He received postdoctoral training at
16:American virologist and quantitative biologist
1060:NIH Director's New Innovator Award recipients
946:"Pew Scholars Directory - Weinberger, Leor S"
8:
745:Tan and Elledge Genome Medicine 2014, 6:55.
669:Cold Spring Harbor Perspectives in Medicine
559:http://commonfund.nih.gov/arra/newinnovator
572:National Institute of Health, April 2015.
557:National Institute of Health, April 2015.
316:Alfred P. Sloan Foundation Research Fellow
18:
696:
421:"Piggyback Virus Could Curb HIV Pandemic"
367:
334:, Avant Garde, and New Innovator Awards.
969:Alfred P. Sloan Foundation, April 2015.
837:"Evolvable 'Resistance-Proof' Therapies"
747:http://genomemedicine.com/content/6/1/55
343:
232:University of California, San Francisco
215:as a Lewis Thomas Fellow, working with
160:. He is credited with discovering the
134:University of California, San Francisco
1001:: CS1 maint: archived copy as title (
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312:Pew Scholar in the Biomedical Sciences
103:NIH Avant-Garde Award for HIV Research
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452:Weinberger, Leor (26 October 2020),
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205:University of Maryland, College Park
943:Pew Charitable Trusts, April 2015.
330:. He is the only person to win the
320:Bill & Melinda Gates Foundation
228:University of California, San Diego
209:University of California, Berkeley
193:NIH Director's New Innovator Award
191:, NIH/NIDA Avant Garde Award, and
100:NIH Director's New Innovator Award
58:University of California, Berkeley
14:
589:"Leor Weinberger | UCSF Profiles"
177:therapeutic interfering particles
536:National Institute on Drug Abuse
1:
189:NIH Directorâs Pioneer Award
187:only person to ever win the
96:NIH Director's Pioneer Award
681:10.1101/cshperspect.a007096
296:Department of Defense DARPA
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378:10.1016/j.cell.2005.06.006
171:fluctuations ('noise') in
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720:Institutes, Gladstone.
278:San Francisco Chronicle
852:Cite journal requires
332:NIH Directorâs Pioneer
158:quantitative biologist
257:human cytomegalovirus
1045:American virologists
236:Gladstone Institutes
213:Princeton University
199:Education and career
138:Gladstone Institutes
63:Princeton University
67:Lewis Thomas Fellow
925:patents.google.com
835:Weinberger, Leor.
726:www.prnewswire.com
150:Leor S. Weinberger
1020:"Leor Weinberger"
593:profiles.ucsf.edu
306:Awards and honors
267:Major discoveries
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124:Synthetic Biology
110:Scientific career
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314:in 2008, an
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217:Thomas Shenk
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130:Institutions
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91:Keck awardee
87:Sloan Fellow
1055:1975 births
781:www.ted.com
261:herpesvirus
93:TED speaker
85:Pew Scholar
44:Citizenship
1034:Categories
988:2014-03-27
956:2015-02-20
930:2020-11-13
906:2020-12-01
882:2020-11-13
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786:2020-11-13
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541:2020-11-13
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461:2020-12-01
438:2023-08-11
338:References
169:stochastic
154:virologist
822:208600143
689:2157-1422
433:1059-1028
298:program,
997:cite web
707:22229121
386:16051143
300:NIH/NIDA
253:HIV/AIDS
242:Research
181:TED talk
120:Virology
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806:bioRxiv
698:3234450
394:8061716
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324:Nature
259:, and
116:Fields
82:Awards
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818:S2CID
425:Wired
390:S2CID
364:arXiv
283:Wired
1003:link
858:help
703:PMID
685:ISSN
429:ISSN
382:PMID
356:Cell
328:Cell
219:and
156:and
32:1975
29:Born
810:doi
693:PMC
677:doi
374:doi
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