985:, there is a notable phenomenon known as the "flare." This occurs when testosterone levels temporarily surge by approximately 50% within the first 1 to 2 weeks of therapy. This increase is a response to the initial stimulation of luteinizing hormone (LH) by the LHRH agonist, leading to a rise in testosterone levels before they begin to decrease as intended. For individuals receiving LHRH agonists as part of gender-affirming care, this temporary increase in testosterone can be particularly distressing, exacerbating gender dysphoria and discomfort. To manage and mitigate these effects, healthcare providers often prescribe antiandrogens during this phase to help block the unwanted increase in testosterone and alleviate the associated distress.
703:
InChI=1S/C59H84N16O12/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64)/t40-,41-,42-,43+,44-,45-,46-,47-,48-/m0/s1
588:
565:
965:
swelling or tenderness, acne, joint/muscle aches or pain, trouble sleeping (insomnia), reduced sexual interest, vaginal discomfort/dryness/itching/discharge, vaginal bleeding, swelling of the ankles/feet, increased urination at night, dizziness, breakthrough bleeding in a female child during the first two months of leuprorelin treatment, weakness, chills, clammy skin, skin redness, itching, or scaling, testicle pain, impotence, depression, or memory problems. The rates of
1178:(EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Camcevi, intended for the treatment of the cancer of the prostate in adult men when the cancer is "hormone-dependent", which means that it responds to treatments that reduce the levels of the hormone testosterone. The applicant for this medicinal product is Accord Healthcare S.L.U. Leuprorelin was approved for medical use in the European Union in May 2022.
661:
40:
1041:(HPG axis). However, normal functioning of this axis requires pulsatile release of GnRH from the hypothalamus. Continuous exposure to an agonist such as leuprorelin for several weeks causes pituitary GnRH receptors to become desensitised and no longer responsive. This desensitisation is the objective of leuprorelin therapy because it ultimately reduces LH and FSH secretion, leading to
31:
4696:
1294:. The $ 875 million settlement broke down to $ 290 million for violating the Prescription Drug Marketing Act, $ 559.5 million to settle federal fraud charges for overcharging Medicare, and $ 25.5 million reimbursement to 50 states and Washington, D.C., for filing false claims with the states' Medicaid programs. The case arose under the
1305:
There have since been various suits concerning leuprorelin use, none successful. They either concern the oversubscription of the drug or undue warning about the side effects. Between 2010 and 2013, the FDA updated the Lupron drug label to include new safety information on the risk of thromboembolism,
964:
Common side effects of leuprorelin injection include redness/burning/stinging/pain/bruising at the injection site, hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, nausea, diarrhea, impotence, testicular shrinkage, constipation, stomach pain, breast
1306:
loss of bone density and convulsions. The FDA then asserted that the benefits of leuprorelin outweigh its risks when used according to its approved labeling. Since 2017, the FDA has been evaluating leuprorelin's connection to pain and discomfort in musculoskeletal and connective tissue.
972:
A cohort of women that were prescribed leuprorelin to delay precocious puberty as children has developed osteoporosis and brittle teeth at an unexpected rate; However, the FDA has not established that these conditions were caused by leuprorelin.
2070:
Gava G, Cerpolini S, Martelli V, Battista G, Seracchioli R, Meriggiola MC (August 2016). "Cyproterone acetate vs leuprolide acetate in combination with transdermal oestradiol in transwomen: a comparison of safety and effectiveness".
3438:
1285:
In
October 2001, the US Department of Justice, states attorneys general, and TAP Pharmaceutical Products, a subsidiary of Abbott Laboratories, settled criminal and civil charges against TAP related to federal and state
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1469:
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Badaru A, Wilson DM, Bachrach LK, et al. (May 2006). "Sequential comparisons of one-month and three-month depot leuprolide regimens in central precocious puberty".
3690:
4550:
2785:
1171:
70:
3620:
3002:
1038:
3386:
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675:
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3860:
1291:
3336:"#513: 10-03-01 TAP PHARMACEUTICAL PRODUCTS INC. AND SEVEN OTHERS CHARGED WITH HEALTH CARE CRIMES COMPANY AGREES TO PAY $ 875 MILLION TO SETTLE CHARGES"
2324:
Di
Lorenzo G, Autorino R, PerdonĂ S, De Placido S (December 2005). "Management of gynaecomastia in patients with prostate cancer: a systematic review".
3810:
876:). This use is controversial since the Lupron label advises against using the drug when one is considering pregnancy, due to a risk of birth defects.
3716:
3027:
2114:
4322:
4302:
3724:
783:
4726:
3975:
3734:
3439:"January - March 2017 | Potential Signals of Serious Risks/New Safety Information Identified by the FDA Adverse Event Reporting System (FAERS)"
3051:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
4599:
4209:
3411:
3183:
3141:
3100:
2928:
2884:
2626:
2585:
2544:
2431:
1950:
1756:
830:
683:
CCNC(=O)1CCCN1C(=O)(CCCNC(=N)N)NC(=O)(CC(C)C)NC(=O)(CC(C)C)NC(=O)(Cc2ccc(cc2)O)NC(=O)(CO)NC(=O)(Cc3cc4c3cccc4)NC(=O)(Cc5ccn5)NC(=O)6CCC(=O)N6
2212:
Schober JM, Byrne PM, Kuhn PJ (2006). "Leuprolide acetate is a familiar drug that may modify sex-offender behaviour: the urologist's role".
4271:
4255:
4250:
3683:
2591:
2177:
Saleh FM, Niel T, Fishman MJ (2004). "Treatment of paraphilia in young adults with leuprolide acetate: a preliminary case report series".
1254:
3299:
3189:
3147:
3106:
2934:
2890:
2632:
2550:
1762:
4746:
4041:
3945:
2255:
Schober JM, Kuhn PJ, Kovacs PG, Earle JH, Byrne PM, Fries RA (2005). "Leuprolide acetate suppresses pedophilic urges and arousability".
1956:
2476:
2302:
2153:
4716:
3536:
Desmarchelier M, Lair S, Dunn M, Langlois I (2008). "Primary hyperaldosteronism in a domestic ferret with an adrenocortical adenoma".
2654:
1079:
872:
in both males and females, and to prevent premature ovulation in cycles of controlled ovarian stimulation for in vitro fertilization (
1692:
1391:
1191:
695:
1344:, but development for these uses was discontinued. The formulation has the tentative brand name Ovarest. As of July 2018, it is in
3222:
914:
2–3, and then cross-sex hormones treatment at age 16. This use of the drug is off-label, however, not having been approved by the
2840:
2810:
2743:
2713:
2683:
2023:"A comparison of 5-year administration of cyproterone acetate or leuprolide acetate in combination with estradiol in transwomen"
1609:
1572:
1535:
1498:
1461:
3676:
332:
230:
102:
4371:
4015:
3699:
3514:
999:
1786:"Subcutaneous depot medroxyprogesterone acetate versus leuprolide acetate in the treatment of endometriosis-associated pain"
4731:
1245:
4686:
2360:
4623:
4574:
4158:
3897:
3892:
1022:
915:
484:
2774:
4226:
4166:
1345:
907:
768:
544:
121:
2661:
2490:
Teutonico D, Montanari S, Ponchel G (March 2012). "Leuprolide acetate: pharmaceutical use and delivery potentials".
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1236:
1227:
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4057:
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1717:
1647:
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in 1973 and was introduced for medical use in 1985. It was initially marketed only for daily injection, but a
433:
4569:
4214:
1298:
with claims filed by
Douglas Durand, a former TAP vice president of sales, and Joseph Gerstein, a doctor at
158:
3647:
Shajnfeld A, Krueger RB (July 2006). "Reforming (Purportedly) Non-Punitive
Responses to Sexual Offending".
1978:
Dreger A (January–February 2009). "Gender identity disorder in childhood: inconclusive advice to parents".
583:
4721:
4426:
4120:
3061:
1315:
1218:
873:
776:
533:
169:
4653:
4638:
3038:
2125:
1273:(1985–2008), by Varian Pharmed( Previously named Varian Darou Pajooh) under the brand name Leupromer and
829:
Leuprorelin was patented in 1973 and approved for medical use in the United States in 1985. It is on the
4541:
4311:
4150:
4112:
3456:
Doraiswamy PM, Xiong GL (2006). "Pharmacological strategies for the prevention of
Alzheimer's disease".
1430:
1209:
1200:
1153:
Eligard was approved by the FDA for palliative treatment of advanced prostate cancer on 24 January 2002.
981:
During the initial phase of luteinizing hormone-releasing hormone (LHRH) agonist therapy in individuals
424:
1314:
As of 2006, leuprorelin was under investigation for possible use in the treatment of mild to moderate
384:
4618:
4162:
1140:
299:
1150:
Viadur was approved by the FDA for palliative treatment of advanced prostate cancer on 6 March 2000.
560:
4579:
4154:
4078:
3998:
3902:
1322:
1274:
1270:
1018:
930:
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4132:
4082:
3481:
3335:
2515:
2280:
2237:
2096:
2052:
2003:
1372:
1333:
1262:. It is also known by its developmental code names A-43818, Abbott-43818, DC-2-269, and TAP-144.
1026:
869:
819:
815:
764:
165:
132:
4494:
4421:
4669:
4504:
4499:
4484:
4464:
4449:
2574:"Anticancer drugs II: Hormonal agents, targeted drugs, and other noncytotoxic anticancer drugs"
2573:
910:. Researchers have recommended puberty blockers after age 12, when the person has developed to
4474:
4396:
4346:
4341:
4170:
3660:
3656:
3594:
3553:
3473:
3307:
3275:
3179:
3173:
3137:
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3096:
3090:
2924:
2918:
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2876:
Rethinking the
Conceptual Base for New Practical Applications in Information Value and Quality
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2622:
2614:
2581:
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2534:
2507:
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2404:
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2194:
2088:
2044:
1995:
1946:
1940:
1921:
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1807:
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1746:
1290:
and illegal marketing of the drug leuprorelin. TAP paid a total of $ 875 million, which was a
903:
269:
257:
52:
4479:
2426:(in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 372–73.
1890:
Clowse ME, Behera MA, Anders CK, Copland S, Coffman CJ, Leppert PC, Bastian LA (March 2009).
4633:
4628:
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3584:
3545:
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2448:
2394:
2333:
2298:
2264:
2221:
2186:
2080:
2034:
1987:
1911:
1903:
1834:
1797:
1725:
1642:
1368:
1341:
1325:
1299:
1295:
1156:
Fensolvi was approved by the FDA for children with central precocious puberty on 4 May 2020.
1092:
884:
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473:
291:
193:
39:
493:
379:
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1337:
1269:
under the brand name Viadur, by Tolmar under the brand names
Eligard and Fensolvi, and by
1144:
1133:
1120:
850:
748:
80:
2920:
Innovation in the
Pharmaceutical Industry: The Process of Drug Discovery and Development
587:
564:
4648:
4220:
4136:
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1287:
982:
926:
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4584:
2225:
2056:
1360:
1329:
1014:
1003:
858:
854:
772:
756:
752:
576:
185:
173:
94:
3092:
The
Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies
2519:
2284:
2241:
2100:
2007:
1942:
Behavioral and Emotional Disorders in Adolescents: Nature, Assessment, and Treatment
1302:'s HMO practice. Durand, Gerstein, and Tufts shared $ 95 million of the settlement.
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413:
213:
208:
189:
3506:
2447:
Wuttke W, Jarry H, Feleder C, Moguilevsky J, Leonhardt S, Seong JY, Kim K (1996).
2503:
1045:
and a dramatic reduction in estradiol and testosterone levels regardless of sex.
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4376:
4191:
4142:
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3760:
3755:
3589:
3572:
3261:
2268:
953:
949:
633:
464:
180:
3549:
3311:
1861:"Lupron, used to halt puberty in children, may cause lasting health problems"
4531:
4526:
4469:
4459:
4406:
4401:
4386:
4381:
4356:
4146:
4106:
3988:
3984:
3957:
3856:
3836:
3831:
3795:
3790:
3780:
3775:
3770:
3750:
3469:
1892:"Ovarian preservation by GnRH agonists during chemotherapy: a meta-analysis"
1802:
1785:
1030:
1011:
895:
823:
807:
795:
312:
74:
22:
3598:
3557:
3477:
3279:
2511:
2464:
2408:
2345:
2276:
2233:
2198:
2092:
2048:
2021:
Gava G, Mancini I, Alvisi S, Seracchioli R, Meriggiola MC (December 2020).
1999:
1925:
1846:
1811:
1722:
World Health Organization model list of essential medicines: 21st list 2019
1462:"Lupron- leuprolide acetate lupron- leuprolide acetate injection, solution"
2472:
2299:"Common Side Effects of Lupron (Leuprolide Acetate Injection) Drug Center"
1907:
952:. Leuprorelin has been tested as a treatment for reducing sexual urges in
4521:
4511:
4489:
4439:
4049:
3846:
3821:
1838:
803:
444:
116:
2615:"An Update on Androgen-Deprivation Therapy for Advanced Prostate Cancer"
2039:
2022:
1730:
453:
30:
4551:
4444:
4181:
2190:
1991:
1007:
899:
744:
399:
388:
2084:
1367:, and one with concurrent diabetes mellitus. It is also used to treat
3571:
Boari A, Papa V, Di Silverio F, Aste G, Olivero D, Rocconi F (2010).
3175:
Concise Dictionary of Pharmacological Agents: Properties and Synonyms
1116:
846:
524:
317:
810:, and pain at the site of injection. Other side effects may include
3412:"More women come forward with complaints about Lupron side effects"
1132:
Lupron injection was approved by the FDA for treatment of advanced
513:
2361:"Women Fear Drug They Used To Halt Puberty Led To Health Problems"
1266:
660:
651:
65:
leuprolide, leuprolidine, A-43818, Abbott-43818, DC-2-269, TAP-144
2841:"Lupaneta Pack- leuprolide acetate and norethindrone acetate kit"
2811:"Lupaneta Pack- leuprolide acetate and norethindrone acetate kit"
3387:"Abbott, AbbVie Defeat Long-Running Lupron Bone, Joint Suit (1)"
1143:
for monthly intramuscular injection was approved by the FDA for
857:. It may also be used for estrogen-dependent conditions such as
504:
275:
4323:
4303:
4275:
3672:
3573:"Type 1 diabetes mellitus and hyperadrenocorticism in a ferret"
3022:
3020:
1359:
Leuprorelin is frequently used in ferrets for the treatment of
1053:
Leuprorelin is available in the following forms, among others:
845:
Leuprorelin may be used in the treatment of hormone-responsive
263:
111:
3976:
4600:
3437:
Center for Drug Evaluation and Research (30 September 2019).
1784:
Crosignani PG, Luciano A, Ray A, Bergqvist A (January 2006).
1017:. GnRH receptor agonists initially increase the secretion of
549:
1394:
Department of Health and Aged Care. Retrieved 30 March 2023
239:
143:
3300:"2 Drug Makers to Pay $ 875 Million to Settle Fraud Case"
1363:. Its use has been reported in a ferret with concurrent
1328:
of leuprorelin is under development for the treatment of
1192:
1147:
treatment of advanced prostate cancer on 26 January 1989.
969:
with leuprorelin have been found to range from 3 to 16%.
941:. It also is used for suppressing estrogen production in
3361:"What You Should Know About Lupron Class Action Lawsuit"
3178:. Springer Science & Business Media. pp. 164–.
1734:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
1604:
1602:
1600:
1598:
1060:
Long-acting depot intramuscular injection (Lupron Depot)
252:
4556:
Tooltip Luteinizing hormone/choriogonadotropin receptor
831:
World Health Organization's List of Essential Medicines
726:
4661:
4243:
4042:
4016:
4009:
3946:
3717:
3700:
3538:
Journal of the American Veterinary Medical Association
1255:
4684:
2536:
Essential Cancer Pharmacology: The Prescriber's Guide
1691:. The American Society of Health-System Pharmacists.
1332:. It was also under development for the treatment of
1246:
2539:. Lippincott Williams & Wilkins. pp. 262–.
1827:
The Journal of Clinical Endocrinology and Metabolism
1530:
1528:
1526:
1524:
4598:
4549:
4540:
4321:
4040:Sex steroid agonists (via negative feedback on the
4030:
3934:
3925:
3883:
3874:
3809:
3733:
3715:
3501:
3499:
3497:
3495:
3126:
3124:
1493:
1491:
1489:
1487:
1057:
Short-acting daily intramuscular injection (Lupron)
918:and without data on long-term effects of this use.
649:
632:
599:
594:
575:
543:
523:
503:
483:
463:
443:
432:
423:
398:
369:
323:
311:
298:
290:
229:
224:
199:
179:
157:
131:
101:
87:
69:
61:
51:
46:
3944:Sex steroid antagonists (via disinhibition of the
2995:"Fensolvi Approved for Central Precocious Puberty"
1567:
1565:
1563:
1561:
1456:
1454:
1452:
1237:
1228:
1063:Long-acting depot subcutaneous injection (Eligard)
3167:
3165:
345:yl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-
4742:Drugs developed by Takeda Pharmaceutical Company
3133:Index Nominum 2000: International Drug Directory
2449:"The neurochemistry of the GnRH pulse generator"
1076:) for the treatment of advanced prostate cancer.
921:They are also sometimes used as alternatives to
412:
4328:Tooltip Gonadotropin-releasing hormone receptor
4308:Tooltip Gonadotropin-releasing hormone receptor
3246:"Drug companies defrauded Medicare of millions"
378:
4179:Others (mixed or unknown mechanism of action):
3981:Tooltip Selective estrogen receptor modulators
2621:. Demos Medical Publishing. pp. 503–512.
1637:
1635:
1219:
1172:Committee for Medicinal Products for Human Use
786:family of medications. It works by decreasing
784:gonadotropin-releasing hormone (GnRH) analogue
4752:World Health Organization essential medicines
4605:Tooltip Follicle-stimulating hormone receptor
4287:
3684:
3136:. Taylor & Francis. 2000. pp. 599–.
1210:
1201:
1066:Long-acting subcutaneous injection (Fensolvi)
8:
3209:
3207:
2923:. Edward Elgar Publishing. pp. 106–07.
2580:. Elsevier Health Sciences. pp. 1296–.
2387:"Flare Associated with LHRH-Agonist Therapy"
1277:(2008–present) under the brand name Lupron.
1080:Leuprolide acetate and norethindrone acetate
120:
21:
16:Manufactured (artificial) injectable hormone
3084:
3082:
2912:
2910:
2908:
2868:
2866:
1683:
1681:
1679:
1677:
1675:
1673:
1671:
1669:
1667:
283:In general: â„ž (Prescription only)
4644:Menotropin (human menopausal gonadotropin)
4590:Menotropin (human menopausal gonadotropin)
4546:
4294:
4280:
4272:
3931:
3880:
3730:
3691:
3677:
3669:
2958:"Lupron (Leuprolide acetate) NDA approval"
2744:"Lupron Depot-Ped- leuprolide acetate kit"
1712:
1710:
948:It is considered a possible treatment for
586:
563:
472:
349:carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-(1
347:butyl]carbamoyl]-2-(4-hydroxyphenyl)ethyl]
3588:
3269:
2655:"Leuprolide Long-acting – Medical Mutual"
2398:
2038:
1915:
1801:
1729:
1431:"Regulatory Decision Summary for Eligard"
1197:Tooltip International Nonproprietary Name
1069:Long-acting subcutaneous implant (Viadur)
492:
57:Lupron, Eligard, Lucrin, Lupaneta, others
1405:"Product monograph brand safety updates"
4691:
2422:Mutschler E, Schäfer-Korting M (2001).
1384:
700:
680:
559:
452:
337:
93:
4021:Tooltip gonadotropin-releasing hormone
3705:Tooltip Gonadotropin-releasing hormone
3507:"Leuprorelin oral - Enteris BioPharma"
2714:"Lupron Depot- leuprolide acetate kit"
2684:"Lupron Depot- leuprolide acetate kit"
1751:. John Wiley & Sons. p. 514.
1610:"Lupron Depot- leuprolide acetate kit"
1260:Tooltip Dénomination Commune Française
577:
20:
3623:from the original on 24 November 2020
3330:
3328:
3293:
3291:
3289:
3225:from the original on 25 February 2018
2479:from the original on 8 December 2015.
2154:"Hormone Therapy in Gender Dysphoria"
2115:"Hormone Therapy in Gender Dysphoria"
1724:. Geneva: World Health Organization.
1695:from the original on 23 December 2016
1251:Tooltip Denominazione Comune Italiana
1115:Leuprorelin was discovered and first
879:It may be used to reduce the risk of
532:
79:
7:
4246:and gonadotropin receptor modulators
3517:from the original on 4 November 2017
3066:Union Register of medicinal products
3005:from the original on 5 November 2020
1871:from the original on 7 December 2020
1546:from the original on 26 October 2020
1123:formulation was introduced in 1989.
212:
2775:"Camcevi (leuprolide) NDA Approval"
2664:from the original on 11 August 2021
2594:from the original on 11 August 2021
1509:from the original on 10 August 2020
1208:, while leuprorelin acetate is its
1039:hypothalamic–pituitary–gonadal axis
906:until they are old enough to begin
512:
403:
3577:Veterinary Research Communications
3513:. Springer Nature Switzerland AG.
2974:from the original on 10 April 2021
2453:Acta Neurobiologiae Experimentalis
1536:"Fensolvi- leuprolide acetate kit"
1242:Tooltip United States Pharmacopeia
1233:Tooltip United States Adopted Name
833:. It is sold under the brand name
14:
4261:Progestogens and antiprogestogens
3861:+estradiol/norethisterone acetate
3649:Developments in Mental Health Law
3613:"Treatment of Chronic Egg Laying"
3458:Expert Opinion on Pharmacotherapy
3192:from the original on 13 June 2021
3150:from the original on 13 June 2021
3109:from the original on 13 June 2021
2965:U.S. Food and Drug Administration
2937:from the original on 13 June 2021
2893:from the original on 13 June 2021
2782:U.S. Food and Drug Administration
2635:from the original on 13 June 2021
2553:from the original on 13 June 2021
2305:from the original on 29 July 2015
2027:European Journal of Endocrinology
1945:. Guilford Press. pp. 556–.
1765:from the original on 20 June 2021
1499:"Eligard- leuprolide acetate kit"
1072:Long-acting leuprolide mesylate (
820:problems with the pituitary gland
743:, is a manufactured version of a
4694:
2851:from the original on 27 May 2021
2821:from the original on 27 May 2021
2791:from the original on 27 May 2021
2754:from the original on 27 May 2021
2724:from the original on 27 May 2021
2694:from the original on 27 May 2021
2393:. 3 Suppl 3 (Suppl 3): S10–S14.
2226:10.1111/j.1464-410X.2006.05975.x
1959:from the original on 2 July 2014
1620:from the original on 27 May 2021
1583:from the original on 27 May 2021
1472:from the original on 27 May 2021
1082:co-packaged pack (Lupaneta Pack)
617:
611:
38:
29:
3037:. 24 March 2022. Archived from
1745:Fischer J, Ganellin CR (2006).
1435:Drug and Health Products Portal
956:and other cases of paraphilia.
708:Key:GFIJNRVAKGFPGQ-LIJARHBVSA-N
3028:"Camcevi: Pending EC decision"
2572:Lehne RA, Rosenthal R (2014).
2533:Butler SK, Govindan R (2010).
1224:Tooltip Japanese Accepted Name
1000:gonadotropin-releasing hormone
798:. Common side effects include
623:
605:
1:
4727:Hormonal antineoplastic drugs
3298:Petersen M (4 October 2001).
3062:"Camcevi Product information"
2879:. IGI Global. pp. 111–.
2613:Su X, Hapani S, Wu S (2011).
2578:Pharmacology for Nursing Care
2338:10.1016/S1470-2045(05)70464-2
1748:Analogue-based Drug Discovery
1392:ELIGARD (Mundipharma Pty Ltd)
1215:Tooltip British Approved Name
1206:Tooltip British Approved Name
1099:-Leu-Leu-Arg-Pro-NHEt (Pyr =
826:may harm foetal development.
4624:Follicle-stimulating hormone
4575:Human chorionic gonadotropin
4159:hydroxyprogesterone caproate
3898:Human chorionic gonadotropin
3893:Follicle-stimulating hormone
2504:10.1517/17425247.2012.662484
2359:Jewett C (2 February 2017).
2179:Journal of Forensic Sciences
1573:"Viadur- leuprolide acetate"
1226:, leuprolide acetate is its
1023:follicle-stimulating hormone
916:Food and Drug Administration
898:, it has been used to delay
359:-imidazol-4-yl)ethyl]-5-oxo-
4256:Estrogens and antiestrogens
4251:Androgens and antiandrogens
4167:medroxyprogesterone acetate
3244:Charatan F (October 2001).
3172:Morton IK, Hall JM (2012).
3095:. Springer. pp. 730–.
2257:Archives of Sexual Behavior
1265:Leuprorelin is marketed by
908:hormone replacement therapy
769:transgender hormone therapy
4768:
4747:Feminizing hormone therapy
3617:Yarmouth Veterinary Center
1980:The Hastings Center Report
1939:Wolfe DA, Mash EJ (2008).
1365:primary hyperaldosteronism
1253:, and leuproréline is its
595:Chemical and physical data
4717:Drugs developed by AbbVie
4204:
3590:10.1007/s11259-010-9369-2
3262:10.1136/bmj.323.7317.828a
3033:European Medicines Agency
2773:Ibrahim A (25 May 2021).
2269:10.1007/s10508-005-7929-2
1896:Journal of Women's Health
1718:World Health Organization
1648:European Medicines Agency
1176:European Medicines Agency
881:premature ovarian failure
790:and therefore decreasing
716:
691:
671:
361:pyrrolidine-2-carboxamide
328:
37:
28:
4392:Leuprorelin (leuprolide)
3786:Leuprorelin (leuprolide)
3550:10.2460/javma.233.8.1297
2956:Esber EC (21 May 1985).
355:yl)ethyl]carbamoyl]-2-(3
4570:Choriogonadotropin alfa
3470:10.1517/14656566.7.1.S1
1292:record high at the time
1095:is Pyr-His-Trp-Ser-Tyr-
773:injection into a muscle
4427:Zoptarelin doxorubicin
2993:Ernst D (4 May 2020).
2492:Expert Opin Drug Deliv
2465:10.55782/ane-1996-1176
2073:Clinical Endocrinology
1244:, leuprorelina is its
1170:On 24 March 2022, the
983:assigned male at birth
782:Leuprorelin is in the
4505:Teverelix (antarelix)
4312:gonadotropin receptor
4151:chlormadinone acetate
3391:news.bloomberglaw.com
2424:Arzneimittelwirkungen
2365:Kaiser Health Network
1908:10.1089/jwh.2008.0857
1803:10.1093/humrep/dei290
4732:Peptide therapeutics
4619:Corifollitropin alfa
4485:Ornirelix (ornitide)
4163:gestonorone caproate
3999:Aromatase inhibitors
3583:(Suppl 1): S107–10.
1839:10.1210/jc.2005-1500
1689:"Leuprolide Acetate"
1190:of the drug and its
1029:and increased serum
4654:Varfollitropin alfa
4639:Follitropin epsilon
4580:Luteinizing hormone
4155:cyproterone acetate
4083:prolactin releasers
3903:Luteinizing hormone
2385:Thompson I (2001).
2040:10.1530/EJE-20-0370
1867:. 2 February 2017.
1437:. 21 September 2023
1351:for endometriosis.
1316:Alzheimer's disease
1275:Abbott Laboratories
1271:TAP Pharmaceuticals
1186:Leuprorelin is the
1161:Society and culture
1019:luteinizing hormone
994:Mechanism of action
931:cyproterone acetate
883:in women receiving
868:It may be used for
248:(Prescription only)
25:
4231:Never to phase III
4133:diethylstilbestrol
3418:. 12 February 2019
3304:The New York Times
2391:Reviews in Urology
2191:10.1520/JFS2003035
1992:10.1353/hcr.0.0102
1790:Human Reproduction
1373:chronic egg laying
1334:precocious puberty
1027:anterior pituitary
887:for chemotherapy.
870:precocious puberty
816:allergic reactions
4682:
4681:
4678:
4677:
4475:Iturelix (antide)
4269:
4268:
4200:
4199:
4171:megestrol acetate
4062:nandrolone esters
4054:anabolic steroids
4032:Antigonadotropins
3921:
3920:
3870:
3869:
3185:978-9-401144-39-1
3143:978-3-88763-075-1
3102:978-1-4757-2085-3
2930:978-1-84376-566-0
2886:978-1-4666-4563-9
2873:Jamil GL (2013).
2628:978-1-935281-91-7
2587:978-0-323-29354-9
2546:978-1-60913-704-5
2433:978-3-8047-1763-3
2214:BJU International
2085:10.1111/cen.13050
1952:978-1-60623-115-9
1758:978-3-527-60749-5
1505:. 26 March 2020.
1102:
1098:
998:Leuprorelin is a
939:transgender women
904:transgender youth
802:, unstable mood,
771:. It is given by
734:
733:
662:Interactive image
545:CompTox Dashboard
343:--1-oxo-pentan-2-
279:
267:
255:
243:
147:
114:
4759:
4737:Puberty blockers
4699:
4698:
4697:
4690:
4663:
4634:Follitropin beta
4629:Follitropin alfa
4606:
4602:
4557:
4553:
4547:
4352:Azagly-nafarelin
4329:
4325:
4309:
4305:
4296:
4289:
4282:
4273:
4245:
4129:ethinylestradiol
4125:estradiol esters
4044:
4022:
4018:
4011:
3982:
3978:
3948:
3936:Progonadotropins
3932:
3881:
3746:Azagly-nafarelin
3731:
3719:
3706:
3702:
3693:
3686:
3679:
3670:
3664:
3633:
3632:
3630:
3628:
3609:
3603:
3602:
3592:
3568:
3562:
3561:
3533:
3527:
3526:
3524:
3522:
3503:
3490:
3489:
3453:
3447:
3446:
3434:
3428:
3427:
3425:
3423:
3408:
3402:
3401:
3399:
3397:
3383:
3377:
3376:
3374:
3372:
3357:
3351:
3350:
3348:
3346:
3332:
3323:
3322:
3320:
3318:
3295:
3284:
3283:
3273:
3241:
3235:
3234:
3232:
3230:
3211:
3202:
3201:
3199:
3197:
3169:
3160:
3159:
3157:
3155:
3128:
3119:
3118:
3116:
3114:
3086:
3077:
3076:
3074:
3072:
3058:
3052:
3050:
3048:
3046:
3041:on 29 March 2022
3024:
3015:
3014:
3012:
3010:
2990:
2984:
2983:
2981:
2979:
2973:
2962:
2953:
2947:
2946:
2944:
2942:
2914:
2903:
2902:
2900:
2898:
2870:
2861:
2860:
2858:
2856:
2837:
2831:
2830:
2828:
2826:
2807:
2801:
2800:
2798:
2796:
2790:
2779:
2770:
2764:
2763:
2761:
2759:
2740:
2734:
2733:
2731:
2729:
2710:
2704:
2703:
2701:
2699:
2680:
2674:
2673:
2671:
2669:
2659:
2651:
2645:
2644:
2642:
2640:
2610:
2604:
2603:
2601:
2599:
2569:
2563:
2562:
2560:
2558:
2530:
2524:
2523:
2487:
2481:
2480:
2444:
2438:
2437:
2419:
2413:
2412:
2402:
2382:
2376:
2375:
2373:
2371:
2356:
2350:
2349:
2321:
2315:
2314:
2312:
2310:
2295:
2289:
2288:
2252:
2246:
2245:
2209:
2203:
2202:
2174:
2168:
2167:
2158:
2150:
2144:
2143:
2138:
2136:
2130:
2124:. Archived from
2119:
2111:
2105:
2104:
2067:
2061:
2060:
2042:
2018:
2012:
2011:
1975:
1969:
1968:
1966:
1964:
1936:
1930:
1929:
1919:
1887:
1881:
1880:
1878:
1876:
1857:
1851:
1850:
1822:
1816:
1815:
1805:
1781:
1775:
1774:
1772:
1770:
1742:
1736:
1735:
1733:
1714:
1705:
1704:
1702:
1700:
1685:
1662:
1661:
1659:
1657:
1639:
1630:
1629:
1627:
1625:
1606:
1593:
1592:
1590:
1588:
1569:
1556:
1555:
1553:
1551:
1532:
1519:
1518:
1516:
1514:
1495:
1482:
1481:
1479:
1477:
1458:
1447:
1446:
1444:
1442:
1427:
1421:
1420:
1418:
1416:
1401:
1395:
1389:
1342:uterine fibroids
1300:Tufts University
1296:False Claims Act
1261:
1257:
1252:
1248:
1243:
1239:
1234:
1230:
1225:
1221:
1216:
1212:
1207:
1203:
1198:
1194:
1136:on 9 April 1985.
1100:
1096:
1093:peptide sequence
933:for suppressing
885:cyclophosphamide
863:uterine fibroids
812:high blood sugar
804:trouble sleeping
767:, or as part of
761:uterine fibroids
739:, also known as
730:
729:
722:
664:
644:
642:
625:
619:
613:
607:
590:
579:
568:
567:
553:
551:
536:
516:
496:
476:
456:
436:
416:
406:
405:
382:
303:
277:
274:
265:
262:
254:
251:
241:
238:
216:
194:Antigonadotropin
145:
142:
124:
113:
110:
97:
83:
42:
33:
26:
24:
4767:
4766:
4762:
4761:
4760:
4758:
4757:
4756:
4707:
4706:
4705:
4695:
4693:
4685:
4683:
4674:
4604:
4594:
4555:
4536:
4327:
4317:
4307:
4300:
4270:
4265:
4236:
4221:Clinical trials
4196:
4075:
4026:
4020:
3980:
3927:
3917:
3866:
3805:
3722:
3711:
3704:
3697:
3667:
3646:
3642:
3640:Further reading
3637:
3636:
3626:
3624:
3611:
3610:
3606:
3570:
3569:
3565:
3544:(8): 1297–301.
3535:
3534:
3530:
3520:
3518:
3505:
3504:
3493:
3455:
3454:
3450:
3436:
3435:
3431:
3421:
3419:
3410:
3409:
3405:
3395:
3393:
3385:
3384:
3380:
3370:
3368:
3359:
3358:
3354:
3344:
3342:
3340:www.justice.gov
3334:
3333:
3326:
3316:
3314:
3297:
3296:
3287:
3243:
3242:
3238:
3228:
3226:
3213:
3212:
3205:
3195:
3193:
3186:
3171:
3170:
3163:
3153:
3151:
3144:
3130:
3129:
3122:
3112:
3110:
3103:
3089:Elks J (2014).
3088:
3087:
3080:
3070:
3068:
3060:
3059:
3055:
3044:
3042:
3026:
3025:
3018:
3008:
3006:
2992:
2991:
2987:
2977:
2975:
2971:
2960:
2955:
2954:
2950:
2940:
2938:
2931:
2917:Hara T (2003).
2916:
2915:
2906:
2896:
2894:
2887:
2872:
2871:
2864:
2854:
2852:
2839:
2838:
2834:
2824:
2822:
2809:
2808:
2804:
2794:
2792:
2788:
2777:
2772:
2771:
2767:
2757:
2755:
2742:
2741:
2737:
2727:
2725:
2712:
2711:
2707:
2697:
2695:
2682:
2681:
2677:
2667:
2665:
2660:. 21 May 2020.
2657:
2653:
2652:
2648:
2638:
2636:
2629:
2619:Prostate Cancer
2612:
2611:
2607:
2597:
2595:
2588:
2571:
2570:
2566:
2556:
2554:
2547:
2532:
2531:
2527:
2489:
2488:
2484:
2446:
2445:
2441:
2434:
2421:
2420:
2416:
2384:
2383:
2379:
2369:
2367:
2358:
2357:
2353:
2323:
2322:
2318:
2308:
2306:
2297:
2296:
2292:
2254:
2253:
2249:
2211:
2210:
2206:
2176:
2175:
2171:
2156:
2152:
2151:
2147:
2134:
2132:
2128:
2117:
2113:
2112:
2108:
2069:
2068:
2064:
2020:
2019:
2015:
1977:
1976:
1972:
1962:
1960:
1953:
1938:
1937:
1933:
1889:
1888:
1884:
1874:
1872:
1859:
1858:
1854:
1824:
1823:
1819:
1783:
1782:
1778:
1768:
1766:
1759:
1744:
1743:
1739:
1716:
1715:
1708:
1698:
1696:
1687:
1686:
1665:
1655:
1653:
1652:. 22 March 2022
1641:
1640:
1633:
1623:
1621:
1608:
1607:
1596:
1586:
1584:
1571:
1570:
1559:
1549:
1547:
1542:. 3 June 2020.
1534:
1533:
1522:
1512:
1510:
1497:
1496:
1485:
1475:
1473:
1460:
1459:
1450:
1440:
1438:
1429:
1428:
1424:
1414:
1412:
1411:. February 2024
1403:
1402:
1398:
1390:
1386:
1381:
1361:adrenal disease
1357:
1349:clinical trials
1338:prostate cancer
1312:
1283:
1259:
1250:
1241:
1232:
1223:
1214:
1205:
1196:
1184:
1168:
1163:
1134:prostate cancer
1129:
1121:depot injection
1113:
1089:
1051:
1049:Available forms
1037:levels via the
996:
991:
979:
962:
943:transgender men
851:prostate cancer
843:
749:prostate cancer
725:
723:
720:(what is this?)
717:
712:
709:
704:
699:
698:
687:
684:
679:
678:
667:
640:
638:
628:
622:
616:
610:
571:
547:
539:
519:
499:
479:
459:
439:
419:
402:
394:
383:
365:
362:
360:
354:
348:
346:
344:
336:
335:
301:
292:Pharmacokinetic
286:
220:
160:
153:
134:
127:
17:
12:
11:
5:
4765:
4763:
4755:
4754:
4749:
4744:
4739:
4734:
4729:
4724:
4719:
4709:
4708:
4704:
4703:
4680:
4679:
4676:
4675:
4673:
4672:
4657:
4656:
4651:
4649:Urofollitropin
4646:
4641:
4636:
4631:
4626:
4621:
4609:
4607:
4596:
4595:
4593:
4592:
4587:
4582:
4577:
4572:
4560:
4558:
4544:
4538:
4537:
4535:
4534:
4529:
4524:
4519:
4514:
4502:
4497:
4492:
4487:
4482:
4477:
4472:
4467:
4462:
4457:
4452:
4447:
4442:
4430:
4429:
4424:
4419:
4414:
4409:
4404:
4399:
4394:
4389:
4384:
4379:
4374:
4369:
4364:
4359:
4354:
4349:
4344:
4332:
4330:
4319:
4318:
4301:
4299:
4298:
4291:
4284:
4276:
4267:
4266:
4264:
4263:
4258:
4253:
4248:
4240:
4235:
4234:
4233:
4232:
4229:
4218:
4212:
4206:
4205:
4202:
4201:
4198:
4197:
4195:
4194:
4189:
4184:
4175:
4174:
4140:
4137:paroxypropione
4110:
4103:chlorpromazine
4091:metoclopramide
4073:
4069:
4036:
4034:
4028:
4027:
4025:
4024:
4006:
3996:
3969:
3940:
3938:
3929:
3923:
3922:
3919:
3918:
3916:
3915:
3913:Urofollitropin
3910:
3905:
3900:
3895:
3889:
3887:
3878:
3872:
3871:
3868:
3867:
3865:
3864:
3854:
3849:
3840:
3839:
3834:
3829:
3824:
3815:
3813:
3807:
3806:
3804:
3803:
3798:
3793:
3788:
3783:
3778:
3773:
3768:
3763:
3758:
3753:
3748:
3739:
3737:
3728:
3713:
3712:
3698:
3696:
3695:
3688:
3681:
3673:
3666:
3665:
3643:
3641:
3638:
3635:
3634:
3604:
3563:
3528:
3491:
3448:
3429:
3403:
3378:
3352:
3324:
3285:
3236:
3203:
3184:
3161:
3142:
3120:
3101:
3078:
3053:
3016:
2985:
2948:
2929:
2904:
2885:
2862:
2832:
2802:
2765:
2735:
2705:
2675:
2646:
2627:
2605:
2586:
2564:
2545:
2525:
2482:
2439:
2432:
2414:
2377:
2351:
2332:(12): 972–79.
2316:
2290:
2263:(6): 691–705.
2247:
2204:
2185:(6): 1343–48.
2169:
2145:
2131:on 5 June 2022
2106:
2079:(2): 239–246.
2062:
2033:(6): 561–569.
2013:
1970:
1951:
1931:
1882:
1852:
1833:(5): 1862–67.
1817:
1776:
1757:
1737:
1706:
1663:
1643:"Camcevi EPAR"
1631:
1594:
1557:
1520:
1483:
1448:
1422:
1396:
1383:
1382:
1380:
1377:
1356:
1355:Veterinary use
1353:
1311:
1308:
1288:medicare fraud
1282:
1279:
1183:
1180:
1174:(CHMP) of the
1167:
1164:
1162:
1159:
1158:
1157:
1154:
1151:
1148:
1137:
1128:
1125:
1112:
1109:
1088:
1085:
1084:
1083:
1077:
1070:
1067:
1064:
1061:
1058:
1050:
1047:
1015:GnRH receptors
995:
992:
990:
987:
978:
977:Lupron "flare"
975:
961:
958:
937:production in
927:spironolactone
842:
839:
837:among others.
777:under the skin
747:used to treat
732:
731:
714:
713:
711:
710:
707:
705:
702:
694:
693:
692:
689:
688:
686:
685:
682:
674:
673:
672:
669:
668:
666:
665:
657:
655:
647:
646:
636:
630:
629:
626:
620:
614:
608:
603:
597:
596:
592:
591:
581:
573:
572:
570:
569:
561:DTXSID50872411
556:
554:
541:
540:
538:
537:
529:
527:
521:
520:
518:
517:
509:
507:
501:
500:
498:
497:
489:
487:
481:
480:
478:
477:
469:
467:
461:
460:
458:
457:
449:
447:
441:
440:
438:
437:
429:
427:
421:
420:
418:
417:
409:
407:
396:
395:
393:
392:
375:
373:
367:
366:
364:
363:
339:
331:
330:
329:
326:
325:
321:
320:
315:
309:
308:
305:
296:
295:
288:
287:
285:
284:
281:
272:
260:
249:
235:
233:
227:
226:
222:
221:
219:
218:
205:
203:
197:
196:
183:
177:
176:
163:
161:administration
155:
154:
152:
151:
149:
139:
137:
129:
128:
126:
125:
107:
105:
99:
98:
91:
85:
84:
77:
67:
66:
63:
59:
58:
55:
49:
48:
44:
43:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
4764:
4753:
4750:
4748:
4745:
4743:
4740:
4738:
4735:
4733:
4730:
4728:
4725:
4723:
4722:GnRH agonists
4720:
4718:
4715:
4714:
4712:
4702:
4692:
4688:
4671:
4668:
4667:Non-peptides:
4665:
4659:
4658:
4655:
4652:
4650:
4647:
4645:
4642:
4640:
4637:
4635:
4632:
4630:
4627:
4625:
4622:
4620:
4617:
4614:
4611:
4610:
4608:
4603:
4597:
4591:
4588:
4586:
4585:Lutropin alfa
4583:
4581:
4578:
4576:
4573:
4571:
4568:
4565:
4562:
4561:
4559:
4554:
4548:
4545:
4543:
4539:
4533:
4530:
4528:
4525:
4523:
4520:
4518:
4515:
4513:
4510:
4509:Non-peptides:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4441:
4438:
4435:
4432:
4431:
4428:
4425:
4423:
4420:
4418:
4415:
4413:
4410:
4408:
4405:
4403:
4400:
4398:
4395:
4393:
4390:
4388:
4385:
4383:
4380:
4378:
4375:
4373:
4370:
4368:
4365:
4363:
4360:
4358:
4355:
4353:
4350:
4348:
4345:
4343:
4340:
4337:
4334:
4333:
4331:
4326:
4320:
4316:
4313:
4306:
4297:
4292:
4290:
4285:
4283:
4278:
4277:
4274:
4262:
4259:
4257:
4254:
4252:
4249:
4247:
4241:
4238:
4237:
4230:
4228:
4225:
4224:
4222:
4219:
4216:
4213:
4211:
4208:
4207:
4203:
4193:
4190:
4188:
4185:
4183:
4180:
4177:
4176:
4172:
4168:
4164:
4160:
4156:
4152:
4148:
4144:
4141:
4138:
4134:
4130:
4126:
4122:
4118:
4114:
4111:
4108:
4104:
4100:
4096:
4092:
4088:
4084:
4080:
4077:
4070:
4067:
4063:
4059:
4055:
4051:
4048:
4046:
4038:
4037:
4035:
4033:
4029:
4019:
4013:
4007:
4004:
4000:
3997:
3994:
3990:
3986:
3979:
3973:
3972:Antiestrogens
3970:
3967:
3963:
3959:
3955:
3954:Antiandrogens
3952:
3950:
3942:
3941:
3939:
3937:
3933:
3930:
3924:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3891:
3890:
3888:
3886:
3882:
3879:
3877:
3876:Gonadotropins
3873:
3862:
3858:
3855:
3853:
3850:
3848:
3845:
3842:
3841:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3817:
3816:
3814:
3812:
3808:
3802:
3799:
3797:
3794:
3792:
3789:
3787:
3784:
3782:
3779:
3777:
3774:
3772:
3769:
3767:
3764:
3762:
3759:
3757:
3754:
3752:
3749:
3747:
3744:
3741:
3740:
3738:
3736:
3732:
3729:
3726:
3721:
3714:
3710:
3709:gonadotropins
3703:
3694:
3689:
3687:
3682:
3680:
3675:
3674:
3671:
3662:
3658:
3654:
3650:
3645:
3644:
3639:
3622:
3618:
3614:
3608:
3605:
3600:
3596:
3591:
3586:
3582:
3578:
3574:
3567:
3564:
3559:
3555:
3551:
3547:
3543:
3539:
3532:
3529:
3516:
3512:
3508:
3502:
3500:
3498:
3496:
3492:
3487:
3483:
3479:
3475:
3471:
3467:
3463:
3459:
3452:
3449:
3444:
3440:
3433:
3430:
3417:
3413:
3407:
3404:
3392:
3388:
3382:
3379:
3366:
3362:
3356:
3353:
3341:
3337:
3331:
3329:
3325:
3313:
3309:
3305:
3301:
3294:
3292:
3290:
3286:
3281:
3277:
3272:
3267:
3263:
3259:
3256:(7317): 828.
3255:
3251:
3247:
3240:
3237:
3224:
3220:
3216:
3215:"Leuprorelin"
3210:
3208:
3204:
3191:
3187:
3181:
3177:
3176:
3168:
3166:
3162:
3149:
3145:
3139:
3135:
3134:
3127:
3125:
3121:
3108:
3104:
3098:
3094:
3093:
3085:
3083:
3079:
3067:
3063:
3057:
3054:
3040:
3036:
3034:
3029:
3023:
3021:
3017:
3004:
3000:
2996:
2989:
2986:
2970:
2966:
2959:
2952:
2949:
2936:
2932:
2926:
2922:
2921:
2913:
2911:
2909:
2905:
2892:
2888:
2882:
2878:
2877:
2869:
2867:
2863:
2850:
2846:
2842:
2836:
2833:
2820:
2816:
2812:
2806:
2803:
2787:
2783:
2776:
2769:
2766:
2753:
2749:
2745:
2739:
2736:
2723:
2719:
2715:
2709:
2706:
2693:
2689:
2685:
2679:
2676:
2663:
2656:
2650:
2647:
2634:
2630:
2624:
2620:
2616:
2609:
2606:
2593:
2589:
2583:
2579:
2575:
2568:
2565:
2552:
2548:
2542:
2538:
2537:
2529:
2526:
2521:
2517:
2513:
2509:
2505:
2501:
2498:(3): 343–54.
2497:
2493:
2486:
2483:
2478:
2474:
2470:
2466:
2462:
2459:(3): 707–13.
2458:
2454:
2450:
2443:
2440:
2435:
2429:
2425:
2418:
2415:
2410:
2406:
2401:
2396:
2392:
2388:
2381:
2378:
2366:
2362:
2355:
2352:
2347:
2343:
2339:
2335:
2331:
2327:
2320:
2317:
2304:
2300:
2294:
2291:
2286:
2282:
2278:
2274:
2270:
2266:
2262:
2258:
2251:
2248:
2243:
2239:
2235:
2231:
2227:
2223:
2220:(4): 684–86.
2219:
2215:
2208:
2205:
2200:
2196:
2192:
2188:
2184:
2180:
2173:
2170:
2166:
2162:
2161:NHS Guideline
2155:
2149:
2146:
2142:
2127:
2123:
2122:NHS Guideline
2116:
2110:
2107:
2102:
2098:
2094:
2090:
2086:
2082:
2078:
2074:
2066:
2063:
2058:
2054:
2050:
2046:
2041:
2036:
2032:
2028:
2024:
2017:
2014:
2009:
2005:
2001:
1997:
1993:
1989:
1985:
1981:
1974:
1971:
1958:
1954:
1948:
1944:
1943:
1935:
1932:
1927:
1923:
1918:
1913:
1909:
1905:
1902:(3): 311–19.
1901:
1897:
1893:
1886:
1883:
1870:
1866:
1862:
1856:
1853:
1848:
1844:
1840:
1836:
1832:
1828:
1821:
1818:
1813:
1809:
1804:
1799:
1796:(1): 248–56.
1795:
1791:
1787:
1780:
1777:
1764:
1760:
1754:
1750:
1749:
1741:
1738:
1732:
1727:
1723:
1719:
1713:
1711:
1707:
1694:
1690:
1684:
1682:
1680:
1678:
1676:
1674:
1672:
1670:
1668:
1664:
1651:
1649:
1644:
1638:
1636:
1632:
1619:
1615:
1611:
1605:
1603:
1601:
1599:
1595:
1582:
1578:
1574:
1568:
1566:
1564:
1562:
1558:
1545:
1541:
1537:
1531:
1529:
1527:
1525:
1521:
1508:
1504:
1500:
1494:
1492:
1490:
1488:
1484:
1471:
1467:
1463:
1457:
1455:
1453:
1449:
1436:
1432:
1426:
1423:
1410:
1409:Health Canada
1406:
1400:
1397:
1393:
1388:
1385:
1378:
1376:
1374:
1370:
1366:
1362:
1354:
1352:
1350:
1347:
1343:
1339:
1335:
1331:
1330:endometriosis
1327:
1324:
1319:
1317:
1309:
1307:
1303:
1301:
1297:
1293:
1289:
1280:
1278:
1276:
1272:
1268:
1263:
1258:
1249:
1240:
1231:
1222:
1213:
1204:
1195:
1189:
1181:
1179:
1177:
1173:
1165:
1160:
1155:
1152:
1149:
1146:
1142:
1138:
1135:
1131:
1130:
1126:
1124:
1122:
1118:
1110:
1108:
1106:
1094:
1086:
1081:
1078:
1075:
1071:
1068:
1065:
1062:
1059:
1056:
1055:
1054:
1048:
1046:
1044:
1040:
1036:
1032:
1028:
1025:(FSH) by the
1024:
1020:
1016:
1013:
1009:
1006:acting as an
1005:
1001:
993:
988:
986:
984:
976:
974:
970:
968:
959:
957:
955:
951:
946:
944:
940:
936:
932:
928:
924:
923:antiandrogens
919:
917:
913:
912:Tanner stages
909:
905:
901:
897:
893:
888:
886:
882:
877:
875:
871:
866:
864:
860:
859:endometriosis
856:
855:breast cancer
852:
848:
840:
838:
836:
832:
827:
825:
822:. Use during
821:
817:
813:
809:
805:
801:
797:
793:
789:
788:gonadotropins
785:
780:
778:
774:
770:
766:
765:early puberty
762:
758:
757:endometriosis
754:
753:breast cancer
750:
746:
742:
738:
728:
721:
715:
706:
701:
697:
690:
681:
677:
670:
663:
659:
658:
656:
653:
648:
637:
635:
631:
604:
602:
598:
593:
589:
585:
582:
580:
578:ECHA InfoCard
574:
566:
562:
558:
557:
555:
546:
542:
535:
534:ChEMBL1201199
531:
530:
528:
526:
522:
515:
511:
510:
508:
506:
502:
495:
491:
490:
488:
486:
482:
475:
471:
470:
468:
466:
462:
455:
451:
450:
448:
446:
442:
435:
431:
430:
428:
426:
422:
415:
411:
410:
408:
401:
397:
390:
386:
381:
377:
376:
374:
372:
368:
358:
352:
342:
338:
334:
327:
322:
319:
316:
314:
310:
306:
304:
297:
293:
289:
282:
280: Rx-only
273:
271:
261:
259:
250:
247:
237:
236:
234:
232:
228:
223:
215:
210:
207:
206:
204:
202:
198:
195:
191:
187:
186:GnRH analogue
184:
182:
178:
175:
174:intramuscular
171:
167:
164:
162:
156:
150:
141:
140:
138:
136:
130:
123:
118:
109:
108:
106:
104:
100:
96:
92:
90:
86:
82:
78:
76:
72:
68:
64:
60:
56:
54:
50:
47:Clinical data
45:
41:
36:
32:
27:
19:
4666:
4660:
4615:
4612:
4566:
4563:
4542:Gonadotropin
4508:
4436:
4434:Antagonists:
4433:
4391:
4338:
4335:
4178:
4143:Progestogens
4058:testosterone
4039:
3966:enzalutamide
3962:bicalutamide
3943:
3885:Preparations
3844:Non-peptide:
3843:
3818:
3785:
3742:
3652:
3648:
3625:. Retrieved
3616:
3607:
3580:
3576:
3566:
3541:
3537:
3531:
3519:. Retrieved
3511:Adis Insight
3510:
3461:
3457:
3451:
3442:
3432:
3420:. Retrieved
3415:
3406:
3394:. Retrieved
3390:
3381:
3369:. Retrieved
3367:. 8 May 2021
3364:
3355:
3343:. Retrieved
3339:
3315:. Retrieved
3303:
3253:
3249:
3239:
3227:. Retrieved
3218:
3194:. Retrieved
3174:
3152:. Retrieved
3132:
3111:. Retrieved
3091:
3069:. Retrieved
3065:
3056:
3043:. Retrieved
3039:the original
3031:
3007:. Retrieved
2998:
2988:
2976:. Retrieved
2964:
2951:
2939:. Retrieved
2919:
2895:. Retrieved
2875:
2853:. Retrieved
2844:
2835:
2823:. Retrieved
2814:
2805:
2793:. Retrieved
2781:
2768:
2756:. Retrieved
2747:
2738:
2726:. Retrieved
2717:
2708:
2696:. Retrieved
2687:
2678:
2666:. Retrieved
2649:
2637:. Retrieved
2618:
2608:
2596:. Retrieved
2577:
2567:
2555:. Retrieved
2535:
2528:
2495:
2491:
2485:
2456:
2452:
2442:
2423:
2417:
2390:
2380:
2368:. Retrieved
2364:
2354:
2329:
2326:Lancet Oncol
2325:
2319:
2307:. Retrieved
2293:
2260:
2256:
2250:
2217:
2213:
2207:
2182:
2178:
2172:
2164:
2160:
2148:
2140:
2133:. Retrieved
2126:the original
2121:
2109:
2076:
2072:
2065:
2030:
2026:
2016:
1983:
1979:
1973:
1961:. Retrieved
1941:
1934:
1899:
1895:
1885:
1873:. Retrieved
1864:
1855:
1830:
1826:
1820:
1793:
1789:
1779:
1769:19 September
1767:. Retrieved
1747:
1740:
1731:10665/325771
1721:
1697:. Retrieved
1654:. Retrieved
1646:
1622:. Retrieved
1613:
1585:. Retrieved
1576:
1548:. Retrieved
1539:
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1502:
1474:. Retrieved
1465:
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1434:
1425:
1413:. Retrieved
1408:
1399:
1387:
1358:
1320:
1313:
1304:
1284:
1264:
1188:generic name
1185:
1169:
1166:Legal status
1114:
1105:pyroglutamyl
1090:
1073:
1052:
1043:hypogonadism
1035:testosterone
997:
989:Pharmacology
980:
971:
967:gynecomastia
963:
960:Side effects
947:
935:testosterone
920:
889:
878:
867:
844:
834:
828:
792:testosterone
781:
740:
736:
735:
724:
718:
356:
350:
340:
300:Elimination
231:Legal status
225:Legal status
190:GnRH agonist
170:subcutaneous
103:License data
18:
4417:Triptorelin
4412:Salmon GnRH
4377:Gonadorelin
4217:from market
4192:Metallibure
4099:haloperidol
4095:risperidone
4087:domperidone
4079:antagonists
4066:oxandrolone
4003:anastrozole
3993:enclomifene
3811:Antagonists
3801:Triptorelin
3766:Gonadorelin
3627:29 December
3464:(1): 1–10.
3422:28 February
3396:28 February
3371:28 February
3229:25 February
3196:25 February
3154:25 February
3113:25 February
2370:17 November
1986:(1): 26–9.
1369:pet parrots
1326:formulation
1281:Controversy
950:paraphilias
892:triptorelin
890:Along with
841:Medical use
800:hot flashes
737:Leuprorelin
645: g·mol
584:100.161.466
324:Identifiers
89:MedlinePlus
62:Other names
53:Trade names
23:Leuprorelin
4711:Categories
4517:Linzagolix
4495:Prazarelix
4455:Cetrorelix
4422:Zoptarelin
4367:Fertirelin
4362:Deslorelin
4315:modulators
4187:Gestrinone
4147:progestins
4117:bifluranol
4085:) (incl.,
3928:(indirect)
3908:Menotropin
3852:Linzagolix
3827:Cetrorelix
3761:Fertirelin
3756:Deslorelin
3720:modulators
3365:Law Answer
3345:24 January
3317:24 January
1875:7 December
1699:8 December
1379:References
1375:behavior.
1145:palliative
954:pedophiles
741:leuprolide
650:3D model (
634:Molar mass
494:EFY6W0M8TG
465:ChemSpider
425:IUPHAR/BPS
385:74381-53-6
380:53714-56-0
371:CAS Number
333:IUPAC name
181:Drug class
122:Leuprolide
4670:ADX-61623
4616:Peptides:
4613:Agonists:
4567:Peptides:
4564:Agonists:
4532:Sufugolix
4527:Relugolix
4500:Ramorelix
4470:Ganirelix
4465:Detirelix
4460:Degarelix
4450:Azaline B
4437:Peptides:
4407:Peforelin
4402:Nafarelin
4387:Histrelin
4382:Goserelin
4357:Buserelin
4339:Peptides:
4336:Agonists:
4227:Phase III
4215:Withdrawn
4121:estradiol
4113:Estrogens
4107:sulpiride
4050:Androgens
3989:clomifene
3985:tamoxifen
3958:flutamide
3857:Relugolix
3837:Ganirelix
3832:Degarelix
3796:Peforelin
3791:Nafarelin
3781:Lecirelin
3776:Histrelin
3771:Goserelin
3751:Buserelin
3725:analogues
3312:0362-4331
3219:Drugs.com
3009:19 August
2941:27 August
2897:27 August
2668:11 August
2639:29 August
2598:29 August
2557:29 August
2057:222832326
1550:20 August
1513:20 August
1127:Approvals
1087:Chemistry
1031:estradiol
1021:(LH) and
1012:pituitary
896:goserelin
824:pregnancy
808:headaches
796:estradiol
353:-indol-3-
313:Excretion
302:half-life
159:Routes of
133:Pregnancy
81:Monograph
75:Drugs.com
4701:Medicine
4522:Opigolix
4512:Elagolix
4490:Ozarelix
4440:Abarelix
4397:Lutrelin
4347:Avorelin
4342:Alarelin
4239:See also
4149:, e.g.,
4115:(incl.,
4076:receptor
4012:agonists
3847:Elagolix
3822:Abarelix
3819:Peptide:
3743:Peptide:
3735:Agonists
3621:Archived
3599:20446034
3558:19180717
3515:Archived
3478:16370917
3280:11597964
3223:Archived
3190:Archived
3148:Archived
3107:Archived
3045:28 March
3003:Archived
2969:Archived
2935:Archived
2891:Archived
2849:Archived
2845:DailyMed
2819:Archived
2815:DailyMed
2786:Archived
2752:Archived
2748:DailyMed
2722:Archived
2718:DailyMed
2692:Archived
2688:DailyMed
2662:Archived
2633:Archived
2592:Archived
2551:Archived
2520:30843402
2512:22335366
2477:Archived
2409:16986003
2346:16321765
2303:Archived
2285:24065433
2277:16362253
2242:19365144
2234:16536753
2199:15568711
2135:22 April
2101:30150360
2093:26932202
2049:33055297
2008:22526704
2000:19213192
1963:24 March
1957:Archived
1926:19281314
1869:Archived
1847:16449344
1812:16176939
1763:Archived
1720:(2019).
1693:Archived
1618:Archived
1614:DailyMed
1581:Archived
1577:DailyMed
1544:Archived
1540:DailyMed
1507:Archived
1503:DailyMed
1470:Archived
1466:DailyMed
1415:24 March
1346:phase II
1323:by mouth
1310:Research
1267:Bayer AG
1117:patented
1004:analogue
849:such as
727:(verify)
445:DrugBank
201:ATC code
135:category
117:DailyMed
4480:LXT-101
4445:Acyline
4182:Danazol
4145:(incl.
4056:(e.g.,
4014:(e.g.,
4001:(e.g.,
3983:(e.g.,
3956:(e.g.,
3723:(incl.
3661:1077282
3521:16 July
3486:5546284
3271:1121385
3071:3 March
2473:8917899
2400:1476081
2309:26 July
2165:Table 1
2141:Table 1
1917:2858300
1656:21 June
1441:2 April
1139:Lupron
1111:History
1074:Camcevi
1008:agonist
1002:(GnRH)
900:puberty
847:cancers
745:hormone
601:Formula
454:DB00007
400:PubChem
389:acetate
307:3 hours
256::
217:)
211: (
209:L02AE02
166:implant
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4552:LH/hCG
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1587:26 May
1476:27 May
1371:with
1340:, and
835:Lupron
818:, and
763:, for
676:SMILES
525:ChEMBL
514:D08113
474:571356
414:657181
318:Kidney
270:â„ž-only
268:
258:â„ž-only
244:
115:
3977:SERMs
3482:S2CID
3035:(EMA)
2972:(PDF)
2961:(PDF)
2789:(PDF)
2778:(PDF)
2658:(PDF)
2516:S2CID
2281:S2CID
2238:S2CID
2157:(PDF)
2129:(PDF)
2118:(PDF)
2097:S2CID
2053:S2CID
2004:S2CID
1650:(EMA)
1182:Names
1141:depot
925:like
696:InChI
652:JSmol
4662:NAMs
4372:GnRH
4324:GnRH
4310:and
4304:GnRH
4244:GnRH
4045:axis
4017:GnRH
4010:GnRH
3949:axis
3718:GnRH
3707:and
3701:GnRH
3657:SSRN
3629:2020
3595:PMID
3554:PMID
3523:2018
3474:PMID
3424:2022
3416:KTNV
3398:2022
3373:2022
3347:2022
3319:2022
3308:ISSN
3276:PMID
3231:2018
3198:2018
3180:ISBN
3156:2018
3138:ISBN
3115:2018
3097:ISBN
3073:2023
3047:2022
3011:2020
2980:2021
2943:2018
2925:ISBN
2899:2018
2881:ISBN
2857:2021
2827:2021
2797:2021
2760:2021
2730:2021
2700:2021
2670:2021
2641:2018
2623:ISBN
2600:2018
2582:ISBN
2559:2018
2541:ISBN
2508:PMID
2469:PMID
2428:ISBN
2405:PMID
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2342:PMID
2311:2015
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2230:PMID
2195:PMID
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2089:PMID
2045:PMID
1996:PMID
1965:2012
1947:ISBN
1922:PMID
1877:2020
1865:STAT
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1808:PMID
1771:2020
1753:ISBN
1701:2016
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1626:2021
1589:2021
1552:2020
1515:2020
1478:2021
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