633:
31:
2702:
1436:
864:
Linagliptin was approved for medical use in the United States, Japan, the
European Union, Canada, and Australia in 2011. In 2020, it was the 293rd most commonly prescribed medication in the United States, with more than
1539:
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InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1
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1459:"International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary names: List 61"
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Neumiller JJ (March 2012). "Pharmacology, efficacy, and safety of linagliptin for the treatment of type 2 diabetes mellitus".
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947:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
601:
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2006:
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1429:"DPP-4 Inhibitors for Type 2 Diabetes: Drug Safety Communication - May Cause Severe Joint Pain"
1005:
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as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.
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806:(but not type 1) in conjunction with exercise and diet. It is generally less preferred than
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1996:
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1062:"Trajenta 5 mg film-coated tablets - Summary of Product Characteristics (SmPC)"
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2016:
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include inflammation of the nose and throat. Serious side effects may include
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million prescriptions. From August 2021 linagliptin became available as a
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815:
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176:
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30:
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1281:"Drug Approval Package: Tradjenta (linagliptin) Tablets NDA #201280"
561:
1931:
738:
CC#CCN1C2=C(N=C1N3CCC(C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C
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1259:(76 ed.). Pharmaceutical Press. 2018. p. 680.
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1185:. American Society of Health-System Pharmacists.
1491:"Linagliptin: medicine to treat type 2 diabetes"
460:
901:Linagliptin belongs to a class of drugs called
435:
414:8--7-(but-2-yn-1-yl)-3-methyl-1--3,7-dihydro-1
1533:
8:
1101:"Tradjenta- linagliptin tablet, film coated"
180:
21:
849:that works by increasing the production of
305:In general: ℞ (Prescription only)
2477:
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1975:
1963:
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1163:
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1464:. World Health Organization. p. 66.
1179:"Linagliptin Monograph for Professionals"
917:(INN). Brand names: Trajenta, Tradjenta.
893:Linagliptin may cause severe joint pain.
540:
2738:Drugs developed by Eli Lilly and Company
1257:British national formulary : BNF 76
1251:
1249:
1247:
2728:Drugs developed by Boehringer Ingelheim
2697:
1433:U.S. Food and Drug Administration (FDA)
938:
755:
735:
627:
500:
411:
153:
1409:from the original on 25 September 2021
1042:from the original on 27 September 2021
1010:Therapeutic Goods Administration (TGA)
20:
1439:from the original on 13 December 2019
1370:"Linagliptin - Drug Usage Statistics"
1144:from the original on 29 December 2019
976:"Linagliptin, tablet, 5 mg, Trajenta"
845:is not recommended. Linagliptin is a
814:as an initial treatment. It is taken
600:
580:
139:
7:
1560:, and other drugs used in diabetes (
1072:from the original on 19 January 2022
980:Pharmaceutical Benefits Scheme (PBS)
218:
2530:Glibenclamide (glyburide)/metformin
2510:Dapagliflozin/saxagliptin/metformin
1471:from the original on 3 October 2020
1325:from the original on 3 October 2022
1111:from the original on 15 August 2022
560:
451:
986:from the original on 31 March 2015
14:
2733:Dipeptidyl peptidase-4 inhibitors
1395:"Linagliptin: FDA-Approved Drugs"
1295:from the original on 3 April 2022
1189:from the original on 6 April 2019
915:international nonproprietary name
853:and decreasing the production of
2700:
847:dipeptidyl peptidase-4 inhibitor
666:
660:
343:75–99% (concentration-dependent)
47:
29:
763:Key:LTXREWYXXSTFRX-QGZVFWFLSA-N
1032:"Trajenta Product information"
672:
654:
1:
1210:The Annals of Pharmacotherapy
117:Tradjenta, Trajenta, Trazenta
2346:Alpha-glucosidase inhibitors
1401:Food and Drug Administration
1319:Boehringer Ingelheim Limited
1287:Food and Drug Administration
794:, sold under the brand name
2308:Aldose reductase inhibitors
2769:
2174:GLP1 poly-agonist peptides
644:Chemical and physical data
363:Pharmacologically inactive
353:Minimal (~10% metabolized)
2620:Sitagliptin/ertugliflozin
2615:Sitagliptin/dapagliflozin
2535:Glimepiride/rosiglitazone
2515:Empagliflozin/linagliptin
2505:Dapagliflozin/saxagliptin
2480:
2033:Glibenclamide (glyburide)
1789:
1778:
1586:
1569:
1136:European Medicines Agency
927:Empagliflozin/linagliptin
771:
746:
726:
722:202 °C (396 °F)
402:
28:
2600:Pioglitazone/sitagliptin
2590:Pioglitazone/glimepiride
2580:Phenformin/sulfonylureas
2525:Gemigliptin/rosuvastatin
2495:Cagrilintide/semaglutide
2630:Sitagliptin/simvastatin
2605:Rosiglitazone/metformin
2585:Pioglitazone/alogliptin
2575:Metformin/teneligliptin
2570:Metformin/sulfonylureas
2550:Metformin/ertugliflozin
2520:Empagliflozin/metformin
2500:Dapagliflozin/metformin
2490:Canagliflozin/metformin
2116:GLP-1 receptor agonists
2635:Vildagliptin/metformin
2595:Pioglitazone/metformin
2625:Sitagliptin/metformin
2610:Saxagliptin/metformin
2565:Metformin/repaglinide
2560:Metformin/gemigliptin
2540:Linagliptin/metformin
1345:"The Top 300 of 2020"
1140:. 17 September 2018.
1068:. 27 September 2021.
1006:"AusPAR: Linagliptin"
2555:Metformin/evogliptin
2485:Alogliptin/metformin
1795:Insulin sensitizers
1550:diabetes medication
913:Linagliptin is the
897:Mechanism of action
798:among others, is a
278:(Prescription only)
254:(Prescription only)
25:
2723:Alkyne derivatives
2674:Never to phase III
2545:Metformin/acarbose
1895:Dual PPAR agonists
1764:Never to phase III
1671:Ultralente insulin
1435:. 28 August 2015.
2688:
2687:
2684:
2683:
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2294:
2207:
2206:
2110:
2109:
1953:
1952:
1774:
1773:
1737:
1736:
1681:ultra-long-acting
1605:Insulin glulisine
1222:10.1345/aph.1Q522
1107:. 21 April 2022.
1038:. 25 April 2012.
789:
788:
707:Interactive image
613:CompTox Dashboard
418:-purine-2,6-dione
301:
286:
273:
261:
249:
174:
16:Chemical compound
2760:
2705:
2704:
2703:
2696:
2478:
2374:SGLT2 inhibitors
2304:
2213:DPP-4 inhibitors
2194:(GLP-1/GIP/GCGR)
2170:
1976:
1964:
1800:
1791:
1780:
1689:Insulin degludec
1651:Insulin glargine
1588:
1571:
1542:
1535:
1528:
1519:
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1502:
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993:
991:
972:
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951:nctr-crs.fda.gov
943:
903:DPP-4 inhibitors
871:generic medicine
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2664:Clinical trials
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2437:
2368:
2340:
2291:
2203:
2168:
2106:
2077:
1971:
1949:
1922:
1889:
1834:/"glitazones" (
1826:
1785:
1770:
1769:
1754:Clinical trials
1733:
1712:
1693:+insulin aspart
1675:
1646:Insulin detemir
1632:
1628:Regular insulin
1614:
1582:
1580:insulin analogs
1565:
1558:insulin analogs
1546:
1516:
1511:
1510:
1500:
1498:
1497:. 25 March 2022
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1291:. 7 June 2011.
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1254:
1245:
1207:
1206:
1202:
1192:
1190:
1177:
1176:
1157:
1147:
1145:
1131:"Trajenta EPAR"
1129:
1128:
1124:
1114:
1112:
1099:
1098:
1085:
1075:
1073:
1060:
1059:
1055:
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945:
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940:
935:
923:
911:
899:
891:
881:Linagliptin is
879:
866:
804:type 2 diabetes
780:
778:
775:(what is this?)
772:
767:
764:
759:
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753:
742:
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712:
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639:
629:DTXSID201021653
615:
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487:
467:
450:
442:
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419:
410:
409:
370:
339:Protein binding
331:
322:Bioavailability
314:Pharmacokinetic
308:
289:
226:
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187:
101:
97:
50:
46:
17:
12:
11:
5:
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2445:
2443:
2439:
2438:
2436:
2435:
2430:
2425:
2420:
2415:
2410:
2408:Luseogliflozin
2405:
2400:
2395:
2390:
2385:
2379:
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2370:
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2209:
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2202:
2201:
2195:
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2176:
2167:
2166:
2161:
2156:
2151:
2146:
2141:
2136:
2131:
2126:
2120:
2118:
2112:
2111:
2108:
2107:
2105:
2104:
2099:
2094:
2088:
2086:
2079:
2078:
2076:
2075:
2073:Glyclopyramide
2070:
2065:
2060:
2055:
2050:
2045:
2040:
2035:
2029:2nd generation
2025:
2024:
2019:
2014:
2009:
2004:
2002:Chlorpropamide
1999:
1994:
1988:1st generation
1984:
1982:
1973:
1969:
1961:
1955:
1954:
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1735:
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1710:
1703:Insulin icodec
1700:
1685:
1683:
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1674:
1673:
1668:
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1642:
1640:
1634:
1633:
1631:
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1622:
1616:
1615:
1613:
1612:
1610:Insulin lispro
1607:
1602:
1600:Insulin aspart
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1594:
1584:
1583:
1574:
1567:
1566:
1547:
1545:
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1515:
1514:External links
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1306:
1272:
1265:
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1200:
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1083:
1053:
1023:
1012:. 21 June 2022
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802:used to treat
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546:
545:
537:
535:
529:
528:
526:
525:
517:
515:
509:
508:
506:
505:
497:
495:
489:
488:
486:
485:
477:
475:
469:
468:
466:
465:
457:
455:
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441:
440:
432:
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423:
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403:
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395:
394:
384:
378:
377:
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365:
364:
361:
355:
354:
351:
345:
344:
341:
335:
334:
329:
324:
318:
317:
310:
309:
307:
306:
303:
294:
279:
266:
255:
241:
239:
233:
232:
228:
227:
225:
224:
211:
209:
203:
202:
197:
195:administration
189:
188:
186:
185:
167:
165:
159:
158:
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145:
144:
137:
127:
126:
123:
119:
118:
115:
109:
108:
44:
40:
39:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
2765:
2754:
2751:
2749:
2746:
2744:
2741:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2720:
2718:
2708:
2698:
2694:
2673:
2671:
2668:
2667:
2665:
2662:
2659:
2656:
2654:
2651:
2650:
2636:
2633:
2631:
2628:
2626:
2623:
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2618:
2616:
2613:
2611:
2608:
2606:
2603:
2601:
2598:
2596:
2593:
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2588:
2586:
2583:
2581:
2578:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2526:
2523:
2521:
2518:
2516:
2513:
2511:
2508:
2506:
2503:
2501:
2498:
2496:
2493:
2491:
2488:
2486:
2483:
2482:
2479:
2476:
2474:
2470:
2460:
2457:
2455:
2454:Bromocriptine
2452:
2450:
2447:
2446:
2444:
2440:
2434:
2433:Velagliflozin
2431:
2429:
2428:Tofogliflozin
2426:
2424:
2423:Sotagliflozin
2421:
2419:
2416:
2414:
2413:Remogliflozin
2411:
2409:
2406:
2404:
2403:Ipragliflozin
2401:
2399:
2398:Ertugliflozin
2396:
2394:
2393:Empagliflozin
2391:
2389:
2388:Dapagliflozin
2386:
2384:
2383:Canagliflozin
2381:
2380:
2378:
2376:/"gliflozins"
2375:
2371:
2365:
2362:
2360:
2357:
2355:
2352:
2351:
2349:
2347:
2343:
2337:
2334:
2332:
2329:
2327:
2324:
2322:
2319:
2317:
2314:
2313:
2311:
2309:
2305:
2302:
2298:
2288:
2285:
2283:
2280:
2278:
2277:Teneligliptin
2275:
2273:
2270:
2268:
2265:
2263:
2260:
2258:
2255:
2253:
2250:
2248:
2245:
2243:
2240:
2238:
2235:
2233:
2230:
2228:
2225:
2223:
2220:
2219:
2217:
2214:
2210:
2199:
2196:
2193:
2190:
2187:
2183:
2180:
2179:
2177:
2175:
2171:
2165:
2162:
2160:
2157:
2155:
2152:
2150:
2147:
2145:
2142:
2140:
2137:
2135:
2132:
2130:
2127:
2125:
2122:
2121:
2119:
2117:
2113:
2103:
2100:
2098:
2095:
2093:
2090:
2089:
2087:
2084:
2080:
2074:
2071:
2069:
2066:
2064:
2061:
2059:
2056:
2054:
2051:
2049:
2046:
2044:
2041:
2039:
2036:
2034:
2030:
2027:
2026:
2023:
2020:
2018:
2015:
2013:
2010:
2008:
2005:
2003:
2000:
1998:
1995:
1993:
1992:Acetohexamide
1989:
1986:
1985:
1983:
1981:
1980:Sulfonylureas
1977:
1974:
1972:
1965:
1962:
1960:
1959:Secretagogues
1956:
1946:
1943:
1941:
1938:
1937:
1935:
1933:
1929:
1925:
1919:
1916:
1914:
1911:
1909:
1906:
1904:
1901:
1900:
1898:
1896:
1892:
1886:
1883:
1881:
1880:Rosiglitazone
1878:
1876:
1875:Rivoglitazone
1873:
1871:
1868:
1866:
1865:Netoglitazone
1863:
1861:
1860:Lobeglitazone
1858:
1856:
1853:
1851:
1848:
1846:
1843:
1842:
1840:
1837:
1833:
1829:
1823:
1820:
1818:
1815:
1813:
1810:
1809:
1807:
1805:
1801:
1798:
1796:
1792:
1788:
1781:
1777:
1763:
1761:
1758:
1757:
1755:
1752:
1749:
1746:
1744:
1741:
1740:
1729:
1726:
1725:
1723:
1721:
1720:
1715:
1708:
1704:
1701:
1698:
1694:
1690:
1687:
1686:
1684:
1682:
1678:
1672:
1669:
1667:
1666:Lente insulin
1664:
1662:
1659:
1656:
1655:+lixisenatide
1652:
1649:
1647:
1644:
1643:
1641:
1639:
1635:
1629:
1626:
1625:
1623:
1621:
1617:
1611:
1608:
1606:
1603:
1601:
1598:
1597:
1595:
1593:
1589:
1585:
1581:
1577:
1572:
1568:
1563:
1559:
1555:
1551:
1543:
1538:
1536:
1531:
1529:
1524:
1523:
1520:
1513:
1496:
1492:
1486:
1483:
1467:
1460:
1454:
1451:
1438:
1434:
1430:
1424:
1421:
1408:
1404:
1402:
1396:
1390:
1387:
1375:
1371:
1365:
1362:
1350:
1346:
1340:
1337:
1324:
1320:
1316:
1310:
1307:
1294:
1290:
1288:
1282:
1276:
1273:
1268:
1266:9780857113382
1262:
1258:
1252:
1250:
1248:
1244:
1239:
1235:
1231:
1227:
1223:
1219:
1216:(3): 358–67.
1215:
1211:
1204:
1201:
1188:
1184:
1180:
1174:
1172:
1170:
1168:
1166:
1164:
1162:
1160:
1156:
1143:
1139:
1137:
1132:
1126:
1123:
1110:
1106:
1102:
1096:
1094:
1092:
1090:
1088:
1084:
1071:
1067:
1063:
1057:
1054:
1041:
1037:
1036:Health Canada
1033:
1027:
1024:
1011:
1007:
1001:
998:
985:
982:. July 2012.
981:
977:
971:
968:
956:
952:
948:
942:
939:
932:
928:
925:
924:
920:
918:
916:
908:
906:
904:
896:
894:
888:
886:
884:
876:
874:
872:
862:
860:
856:
852:
848:
844:
843:breastfeeding
840:
836:
832:
828:
824:
819:
817:
813:
812:sulfonylureas
809:
805:
801:
797:
793:
783:
776:
770:
761:
756:
752:
745:
736:
732:
725:
721:
719:
718:Melting point
715:
708:
704:
703:
701:
698:
693:
686:
684:
680:
653:
651:
647:
642:
634:
630:
626:
625:
623:
614:
610:
603:
599:
598:
596:
594:
590:
583:
579:
578:
576:
574:
570:
563:
559:
558:
556:
554:
550:
543:
539:
538:
536:
534:
530:
523:
519:
518:
516:
514:
510:
503:
499:
498:
496:
494:
490:
483:
479:
478:
476:
474:
470:
463:
459:
458:
456:
449:
445:
438:
434:
433:
431:
429:
425:
417:
412:
408:
401:
396:
392:
388:
385:
383:
379:
375:
373:
366:
362:
360:
356:
352:
350:
346:
342:
340:
336:
332:
325:
323:
319:
315:
311:
304:
302: Rx-only
295:
292:
280:
277:
267:
265:
256:
253:
243:
242:
240:
238:
234:
229:
221:
216:
213:
212:
210:
208:
204:
201:
198:
196:
190:
183:
178:
169:
168:
166:
164:
160:
156:
152:
150:
146:
142:
138:
136:
132:
128:
124:
120:
116:
114:
110:
106:
105:
92:
45:
43:Pronunciation
41:
38:Clinical data
36:
32:
27:
19:
2748:Quinazolines
2473:Combinations
2418:Sergliflozin
2287:Vildagliptin
2282:Trelagliptin
2262:Omarigliptin
2251:
2237:Garvagliptin
2164:Taspoglutide
2154:Orforglipron
2149:Lixisenatide
2083:Meglitinides
2038:Glibornuride
2028:
2012:Metahexamide
2007:Glycyclamide
1987:
1940:Cagrilintide
1930:analogs and
1918:Tesaglitazar
1913:Saroglitazar
1908:Muraglitazar
1885:Troglitazone
1870:Pioglitazone
1850:Darglitazone
1784:Non-insulins
1717:
1707:+semaglutide
1697:+liraglutide
1680:
1637:
1620:short-acting
1619:
1591:
1499:. Retrieved
1494:
1485:
1473:. Retrieved
1453:
1441:. Retrieved
1432:
1423:
1413:24 September
1411:. Retrieved
1398:
1389:
1377:. Retrieved
1373:
1364:
1352:. Retrieved
1348:
1339:
1327:. Retrieved
1318:
1309:
1297:. Retrieved
1284:
1275:
1256:
1213:
1209:
1203:
1191:. Retrieved
1182:
1146:. Retrieved
1134:
1125:
1113:. Retrieved
1104:
1074:. Retrieved
1065:
1056:
1044:. Retrieved
1035:
1026:
1014:. Retrieved
1009:
1000:
990:26 September
988:. Retrieved
979:
970:
958:. Retrieved
950:
941:
912:
900:
892:
889:Side effects
880:
877:Medical uses
863:
831:pancreatitis
823:side effects
820:
795:
791:
790:
779:
773:
602:ChEMBL237500
415:
369:Elimination
333:= 1.5 hours)
237:Legal status
231:Legal status
163:License data
18:
2743:Piperidines
2660:from market
2272:Sitagliptin
2267:Saxagliptin
2257:Melogliptin
2252:Linagliptin
2247:Gosogliptin
2242:Gemigliptin
2215:/"gliptins"
2200:(GLP-1/GIP)
2198:Tirzepatide
2192:Retatrutide
2159:Semaglutide
2144:Liraglutide
2134:Dulaglutide
2129:Danuglipron
2124:Albiglutide
2102:Repaglinide
2097:Nateglinide
2092:Mitiglinide
2085:/"glinides"
2068:Glisoxepide
2053:Glimepiride
2043:Glicaramide
2022:Tolbutamide
1997:Carbutamide
1945:Pramlintide
1903:Aleglitazar
1855:Englitazone
1845:Ciglitazone
1750:from market
1661:NPH insulin
1638:long-acting
1592:fast-acting
1501:21 November
1475:10 November
1443:1 September
1148:11 February
873:in the US.
792:Linagliptin
690: g·mol
582:CHEBI:68610
437:668270-12-0
398:Identifiers
359:Metabolites
182:Linagliptin
149:MedlinePlus
122:Other names
113:Trade names
23:Linagliptin
2717:Categories
2449:Benfluorex
2336:Zenarestat
2326:Ranirestat
2321:Fidarestat
2316:Epalrestat
2232:Evogliptin
2227:Anagliptin
2222:Alogliptin
2063:Gliquidone
2048:Gliclazide
2017:Tolazamide
1822:Phenformin
1804:Biguanides
1315:"10 years"
960:22 October
933:References
835:joint pain
827:angioedema
800:medication
695:3D model (
683:Molar mass
542:3X29ZEJ4R2
513:ChemSpider
473:IUPHAR/BPS
428:CAS Number
407:IUPAC name
349:Metabolism
2753:Xanthines
2670:Phase III
2658:Withdrawn
2459:Imeglimin
2364:Voglibose
2331:Tolrestat
2182:Mazdutide
2139:Exenatide
2058:Glipizide
1817:Metformin
1760:Phase III
1748:Withdrawn
1719:inhalable
1379:7 October
1354:7 October
1329:3 October
1299:3 October
1238:207264493
1183:Drugs.com
1115:3 October
1076:3 October
1046:3 October
883:indicated
839:pregnancy
837:. Use in
808:metformin
796:Tradjenta
382:Excretion
376:~24 hours
371:half-life
193:Routes of
141:Monograph
135:Drugs.com
2707:Medicine
2359:Miglitol
2354:Acarbose
1812:Buformin
1576:Insulins
1554:insulins
1466:Archived
1437:Archived
1407:Archived
1374:ClinCalc
1349:ClinCalc
1323:Archived
1293:Archived
1230:22318932
1187:Archived
1142:Archived
1109:Archived
1105:DailyMed
1070:Archived
1040:Archived
984:Archived
921:See also
859:pancreas
855:glucagon
816:by mouth
782:(verify)
493:DrugBank
462:10096344
207:ATC code
200:By mouth
177:DailyMed
2184:(GLP-1/
1730:Afrezza
1727:Exubera
1193:6 April
1016:9 April
857:by the
851:insulin
821:Common
688:472.553
650:Formula
522:8271879
502:DB08882
448:PubChem
389:(80%),
293:Rx-only
290:WARNING
262::
223:)
217: (
215:A10BH05
179::
155:a611036
125:BI-1356
2693:Portal
2653:WHO-EM
1932:DACRAs
1928:Amylin
1743:WHO-EM
1495:NHS UK
1263:
1236:
1228:
867:
731:SMILES
593:ChEMBL
562:D09566
326:~30% (
287:
274:
264:℞-only
250:
175:
107:
2442:Other
2300:Other
1548:Oral
1469:(PDF)
1462:(PDF)
1403:(FDA)
1399:U.S.
1289:(FDA)
1285:U.S.
1234:S2CID
1138:(EMA)
1066:(emc)
909:Names
751:InChI
697:JSmol
573:ChEBI
391:urine
387:Feces
2186:GCGR
1836:PPAR
1832:TZDs
1556:and
1503:2022
1477:2016
1445:2015
1415:2021
1381:2022
1356:2022
1331:2022
1301:2022
1261:ISBN
1226:PMID
1195:2019
1150:2020
1117:2022
1078:2022
1048:2022
1018:2023
992:2014
962:2023
841:and
810:and
553:KEGG
533:UNII
482:6318
393:(5%)
316:data
131:AHFS
104:-tin
102:GLIP
1970:ATP
1562:A10
1218:doi
955:FDA
618:EPA
452:CID
330:max
276:POM
220:WHO
100:-ə-
98:LIN
2719::
2666::
2031::
1990::
1756::
1695:,
1552:,
1493:.
1431:.
1405:.
1397:.
1372:.
1347:.
1321:.
1317:.
1283:.
1246:^
1232:.
1224:.
1214:46
1212:.
1181:.
1158:^
1133:.
1103:.
1086:^
1064:.
1034:.
1008:.
978:.
953:.
949:.
905:.
861:.
833:,
829:,
818:.
664:28
658:25
298:EU
283:US
270:UK
259:CA
252:S4
246:AU
172:US
2695::
2188:)
1968:K
1838:)
1709:)
1705:(
1699:)
1691:(
1657:)
1653:(
1578:/
1564:)
1541:e
1534:t
1527:v
1505:.
1479:.
1447:.
1417:.
1383:.
1358:.
1333:.
1303:.
1269:.
1240:.
1220::
1197:.
1152:.
1119:.
1080:.
1050:.
1020:.
994:.
964:.
865:1
699:)
676:2
673:O
670:8
667:N
661:H
655:C
620:)
616:(
416:H
328:T
300::
285::
272::
248::
133:/
91:/
88:n
85:ɪ
82:t
79:p
76:ɪ
73:l
70:ɡ
67:ˈ
64:ə
61:n
58:ɪ
55:l
52:ˌ
49:/
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
