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where she used transgenic mouse models of multi-stage cancer progression and demonstrated that chronic inflammation is established in early cancers and subsequently drives tumor development. Her later research has identified critical immune-regulatory programs that represent cancer vulnerabilities
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when they are close to tumor cells, which promotes the proliferation and invasion of tumor cells. Her research has emphasized the need to understand the tumor microenvironment in understanding cancer progression. She showed that dying cancer cells release factors that induce a CD8 T cell-mediated
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Coussens' research considers immune therapies for cancer treatment. To do this, she looks at how immune cells regulate aspects of tumor cell development and the role of leukocytes. She makes use of breast, HPV-associated squamous, pancreas and mesothelioma mouse cancer models, in combination with
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is an
American cancer scientist who is Professor and Chair of the Department of Cell, Developmental and Cancer Biology and Deputy Director for Basic and Translational Research in the Knight Cancer Institute at the
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A Ullrich; L Coussens; J S Hayflick; et al. (1 May 1984). "Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells".
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Coussens showed that some immune cells are hijacked to promote tumor growth and metastasis. She uncovered the intra-cellular communication processes which cause tumor cells to trigger CD4
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https://bg.linkedin.com/posts/society-for-immunotherapy-of-cancer-sitc_we-are-delighted-to-welcome-dr-lisa-m-coussens-activity-6990311019914874880-FCaT
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Regulation of junB expression by transforming growth factor-beta, adenovirus12-E1A, and by the retinoblastoma susceptibility gene product
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Regulation of junB expression by transforming growth factor-beta, adenovirus12-E1A, and by the retinoblastoma susceptibility gene product
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to recruit macrophages to early tumors. Macrophages are white blood cells that are usually involved with clearing debris, but produce
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Hanahan D; Coussens LM (20 March 2012). "Accessories to the crime: functions of cells recruited to the tumor microenvironment".
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639:"American Association for Cancer Research Inaugurates New Leadership at the AACR Annual Business Meeting of Members 2022"
113:. She worked at Genentech, Inc. (1981-1988) with Axel Ullrich PhD researching growth factor receptors and cloned the
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human cancer specimens, to identify immune-regulated pathways that may be susceptible to therapeutic targeting.
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L. M. Coussens (29 March 2002). "Matrix
Metalloproteinase Inhibitors and Cancer--Trials and Tribulations".
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2023 15th
Margaret L Kripke Legend Award For Promotion of Women in Cancer Medicine and Cancer Science
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2022 Elected Fellow of the
Academy of Immuno-Oncology (Society of Immunotherapy of Cancer (SITC))
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868:"OHSU scientists Lisa Coussens, John Crabbe named 2018 AAAS fellows | OHSU Research News"
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583:"Kineta Announces Formation of New Immuno-oncology Focused Scientific Advisory Board"
307:(January 2006). "Paradoxical roles of the immune system during cancer development".
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743:"AACR-Women in Cancer Research Charlotte Friend Lectureship: Past Recipients"
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2019 Elected Fellow of the
American Association for Cancer Research Academy
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https://www.nasonline.org/news-and-multimedia/news/2023-nas-election.html
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Susan G. Komen
Brinker Award for Scientific Distinction in Basic Science
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2012 AACR-Women in Cancer
Research Charlotte Friend Memorial Lectureship
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2022 Elected
President of the American Association for Cancer Research
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that can be therapeutically targeted to slow cancer progression.
535:"Lisa M. Coussens M.D. (h.c.), Ph.D., FAACR | OHSU People | OHSU"
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817:"AACR Princess Takamatsu Memorial Lectureship: Past Recipients"
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2018 Career Award from the
European Academy of Tumor Immunology
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2023 Elected Fellow of the
National Academy of Sciences (USA)
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expression. She was a postdoctoral researcher working with
767:"Past Winners of the NCI Rosalind E. Franklin Award - NCI"
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2018 12th AACR-Princess Takamatsu Memorial Lectureship
663:"Q&A: Lisa Coussens on Her Leadership Year Ahead"
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American Association for the Advancement of Science
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821:American Association for Cancer Research (AACR)
747:American Association for Cancer Research (AACR)
722:American Association for Cancer Research (AACR)
643:American Association for Cancer Research (AACR)
158:In 2022, Coussens was elected President of the
978:Oregon Health & Science University faculty
718:"AACR Gertrude B. Elion Cancer Research Award"
121:for her doctoral research, where she studied
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968:University of California, Los Angeles alumni
97:. She served as 2022-2023 President of the
872:OHSU Research News | Research News at OHSU
18:
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109:Coussens was an undergraduate student at
611:"Breast Cancer Awards & Recognition"
173:American Association for Cancer Research
160:American Association for Cancer Research
99:American Association for Cancer Research
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795:National Foundation for Cancer Research
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131:University of California, San Francisco
58:University of California, San Francisco
848:Oregon Health & Science University
95:Oregon Health & Science University
54:Oregon Health & Science University
16:American cancer scientist and academic
973:San Francisco State University alumni
119:University of California, Los Angeles
33:University of California, Los Angeles
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188:2018 Doctor in Medicine from the
117:proto-oncogene. She moved to the
919:MD Anderson Continuing Education
679:10.1158/2159-8290.CD-ND2022-0003
155:immune response against cancer.
185:13th Rosalind E. Franklin Award
206:2018 Elected as Fellow of the
111:San Francisco State University
37:San Francisco State University
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509:Coussens, Lisa Marie (1993).
937:National Academy of Sciences
988:American cancer researchers
983:Fellows of the AACR Academy
915:"Lisa M. Coussens, MD, PhD"
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190:University of Buenos Aires
993:American women scientists
370:10.1016/J.CCR.2012.02.022
241:"Inflammation and cancer"
183:National Cancer Institute
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933:"Lisa M. Coussens – NAS"
152:epidermal growth factors
105:Early life and education
464:10.1126/SCIENCE.1067100
175:Gertrude B. Elion Award
792:"Lisa Coussens, Ph.D."
673:(5): OF3. 2022-05-02.
310:Nature Reviews Cancer
229:Selected publications
815:Beveridge, Michael.
741:Beveridge, Michael.
458:(5564): 2387–2392.
259:10.1038/NATURE01322
138:Research and career
716:McLaughlin, Erin.
587:www.prnewswire.com
301:Karin E. de Visser
411:(5967): 418–425.
239:(December 2002).
235:Lisa M Coussens;
166:Awards and honors
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496:References
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687:2159-8274
521:732921603
488:Q29544430
472:0036-8075
441:Q29616544
425:1476-4687
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61:Genentech
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