483:(Aropax, Deroxat, Divarius, Dropax, Dropaxin, Frosinor, Motivan, Paxil, Paxil CR, Serestill, Seroxat, Tagonis; BRL-29060, BRL-29060A, FG-7051, NNC-207051, SI-211103) – selective serotonin reuptake inhibitor
784:
Odland AU, Kristensen JL, Andreasen JT (March 2021). "Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice".
741:
Andersen KA, Carhart-Harris R, Nutt DJ, Erritzoe D (February 2021). "Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern-era clinical studies".
663:
Nomani H, Mohammadpour AH, Moallem SM, YazdanAbad MJ, Barreto GE, Sahebkar A (2020). "Anti-Androgen Drugs in the
Treatment of Obsessive-Compulsive Disorder: A Systematic Review".
880:
Berlin HA, Hamilton H, Hollander E (2008). "Experimental therapeutics for refractory obsessive-compulsive disorder: translational approaches and new somatic developments".
1022:
706:
Moreno FA, Wiegand CB, Taitano EK, Delgado PL (November 2006). "Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder".
1085:
622:
Schechter LE, Lin Q, Smith DL, Zhang G, Shan Q, Platt B, Brandt MR, Dawson LA, Cole D, Bernotas R, Robichaud A, Rosenzweig-Lipson S, Beyer CE (May 2008).
55:(immune globulin 10%, 10% high purity immunoglobulin, 10% IVIG, NewGam, Newnorm, Octagam 10%, Octagam, Panzyga) – immunoglobulin / immunostimulant
1179:
1050:
493:(Aremis, Besitran, Gladem, J Zoloft, Lustral, Serad, Serlain, Tatig, Zoloft; CP-51974, CP-51974-01) – selective serotonin reuptake inhibitor
139:(Risperdal, Risperdal Consta, Risperdal Depot; JNJ-410397-AAA, R-64766, R064766) – atypical antipsychotic / monoamine receptor modulator
1015:
372:
268:(EMD-49980) – dopamine receptor agonist, serotonin receptor modulator, adrenergic receptor modulator, and serotonin reuptake inhibitor
1031:
27:
457:-citalopram; Cipralex, Entact, Lexapro, Seroplex, Sipralex, Sipralexa; LU-26054; MLD-55) – selective serotonin reuptake inhibitor
1008:
534:
1174:
411:
1100:
34:
Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
399:
97:(4'-F-CBD; fluorinated cannabidiol; HUF-101, HUF-102, HUF-103) – cannabinoid receptor modulator, other actions
446:
829:"What is the clinical evidence on psilocybin for the treatment of psychiatric disorders? A systematic review"
475:(Depromel, Luvox, Luvox CR; SME-3110) – selective serotonin reuptake inhibitor and sigma-1 receptor agonist
350:
94:
217:
1136:
505:
296:
52:
38:
This list was last comprehensively updated in
September 2021. It is likely to become outdated with time.
1126:
624:"Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466"
110:(Alodil, Melitor, Thymanax, Valdoxan, Vestin; AGO-178, AGO178C, S-20098, S-20098-F55) – serotonin 5-HT
340:
407:
390:
322:
911:"Why have early investigational therapies of obsessive-compulsive disorder failed to materialise?"
809:
766:
688:
465:(Prozac, Prozac Weekly, Reneuron, Sarafem; LY-110140) – selective serotonin reuptake inhibitor
253:
977:
932:
897:
858:
801:
758:
723:
680:
645:
604:
233:
172:(R-1678, RG-6718, RG1678, RO-4917838) – glycine GlyT1 inhibitors / glycine reuptake inhibitor
445:(Anafranil) – tricyclic antidepressant / monoamine reuptake inhibitor and receptor modulator
203:
119:
967:
957:
922:
889:
848:
840:
793:
750:
715:
672:
635:
594:
584:
79:
344:
1042:
972:
945:
853:
828:
599:
572:
421:
676:
1168:
813:
770:
692:
362:
1140:
1109:
1063:
844:
509:
494:
486:
484:
476:
468:
466:
458:
450:
442:
314:
285:
269:
261:
249:
237:
229:
221:
220:(OREX-004) – selective serotonin reuptake inhibitor and opioid receptor antagonist
185:
173:
153:
148:
140:
132:
123:
115:
103:
98:
83:
68:
56:
927:
910:
1152:
1130:
1094:
1071:
521:
472:
332:
326:
241:
225:
177:
136:
107:
60:
946:"Investigational and Experimental Drugs to Treat Obsessive-Compulsive Disorder"
573:"Investigational and Experimental Drugs to Treat Obsessive-Compulsive Disorder"
1148:
1144:
1079:
1075:
1067:
1059:
797:
517:
513:
490:
480:
462:
403:
366:
308:
304:
169:
417:
386:
376:
358:
318:
273:
265:
189:
981:
936:
901:
862:
805:
762:
727:
684:
649:
640:
623:
608:
26:
that are currently under development for clinical use in the treatment of
719:
380:
354:
336:
144:
131:
receptor agonists (SSA-426, WAY-163426, WAY-211612, WAY-253752, WAY-426)
64:
1000:
962:
589:
754:
893:
1086:
995:
102:
AbbVie/Rugen research programme – unspecified mechanism of action
184:-cycloserine; TIK-101) – glutamate NMDA receptor partial agonist
152:
Sosei
Heptares research programme – various mechanisms of action
394:
23:
1051:
1004:
20:
list of investigational obsessive–compulsive disorder drugs
63:(BHV-4157, BHV-4157a, FC-4157; trigriluzole) – prodrug of
147:(SecreFlo; INN-329, RG-1068) – hormone/diagnostic agent
1032:
1091:
Tooltip
Serotonin-norepinephrine reuptake inhibitors
944:
Grassi G, Cecchelli C, Vignozzi L, Pacini S (2020).
571:
Grassi G, Cecchelli C, Vignozzi L, Pacini S (2020).
1119:
1041:
114:receptor antagonist and melatonin receptor agonist
1101:
228:(AFQ-056) – glutamate mGlu5 receptor antagonist
1056:Tooltip Selective serotonin reuptake inhibitors
566:
564:
562:
560:
558:
556:
554:
552:
550:
1016:
8:
82:(various) – cannabinoid receptor modulators
291:Formal development never or not yet started
1023:
1009:
1001:
192:(CP-448187, CP-448187-01) – serotonin 5-HT
971:
961:
926:
852:
639:
598:
588:
827:Castro Santos H, Gama Marques J (2021).
909:Marazziti D, Dell'Osso L (April 2015).
546:
414:(LSD)) – serotonin receptor modulators
7:
373:Nonsteroidal anti-inflammatory drugs
244:(Setrodon; TO-2061) – serotonin 5-HT
347:) – cannabinoid receptor modulators
14:
1106:Tooltip Tricyclic antidepressants
677:10.2174/0929867326666191209142209
524:) – monoamine receptor modulators
30:(OCD) but are not yet approved.
1180:Experimental psychiatric drugs
845:10.1097/j.pbj.0000000000000128
1:
928:10.1517/13543784.2015.1005735
535:List of investigational drugs
383:) – cyclooxygenase inhibitors
276:(SB-200646A) – serotonin 5-HT
127:Dual SSRIs and serotonin 5-HT
122:– orexin receptor antagonist
28:obsessive–compulsive disorder
426:-methyltransferase inhibitor
1196:
915:Expert Opin Investig Drugs
412:lysergic acid diethylamide
47:Actively under development
798:10.1016/j.bbr.2020.113093
400:Serotonergic psychedelics
351:NMDA receptor modulators
164:Development discontinued
1137:Atypical antipsychotics
628:Neuropsychopharmacology
506:Atypical antipsychotics
89:No development reported
74:Preclinical development
1127:Typical antipsychotics
996:AdisInsight - Springer
641:10.1038/sj.npp.1301503
236:– glutamate modulator
67:/ glutamate modulator
432:Clinically used drugs
218:Fluoxetine/naltrexone
159:Not under development
743:Acta Psychiatr Scand
720:10.4088/jcp.v67n1110
408:psilocybin mushrooms
341:tetrahydrocannabinol
284:receptor antagonist
248:receptor antagonist
95:4'-Fluorocannabidiol
963:10.2147/JEP.S255375
590:10.2147/JEP.S255375
391:monoclonal antibody
323:cyproterone acetate
214:receptor antagonist
200:receptor antagonist
1175:Drug-related lists
755:10.1111/acps.13249
1162:
1161:
1035:pharmacotherapies
894:10.1002/msj.20045
708:J Clin Psychiatry
671:(40): 6825–6836.
301:receptor agonists
260:receptor agonist
183:
80:Cannabis extracts
42:Under development
1187:
1107:
1103:
1092:
1088:
1057:
1053:
1034:
1025:
1018:
1011:
1002:
985:
975:
965:
940:
930:
905:
867:
866:
856:
824:
818:
817:
781:
775:
774:
738:
732:
731:
703:
697:
696:
660:
654:
653:
643:
619:
613:
612:
602:
592:
568:
375:(NSAIDs) (e.g.,
256:– serotonin 5-HT
206:– serotonin 5-HT
181:
1195:
1194:
1190:
1189:
1188:
1186:
1185:
1184:
1165:
1164:
1163:
1158:
1115:
1105:
1090:
1055:
1043:Antidepressants
1037:
1029:
992:
950:J Exp Pharmacol
943:
908:
879:
876:
874:Further reading
871:
870:
826:
825:
821:
786:Behav Brain Res
783:
782:
778:
740:
739:
735:
714:(11): 1735–40.
705:
704:
700:
662:
661:
657:
621:
620:
616:
577:J Exp Pharmacol
570:
569:
548:
543:
531:
502:
500:Off-label drugs
439:
434:
300:
293:
283:
279:
259:
247:
213:
209:
199:
195:
166:
161:
130:
113:
91:
76:
49:
44:
12:
11:
5:
1193:
1191:
1183:
1182:
1177:
1167:
1166:
1160:
1159:
1157:
1156:
1134:
1123:
1121:
1117:
1116:
1114:
1113:
1098:
1083:
1047:
1045:
1039:
1038:
1030:
1028:
1027:
1020:
1013:
1005:
999:
998:
991:
990:External links
988:
987:
986:
941:
906:
888:(3): 174–203.
882:Mt Sinai J Med
875:
872:
869:
868:
833:Porto Biomed J
819:
776:
749:(2): 101–118.
733:
698:
655:
634:(6): 1323–35.
614:
545:
544:
542:
539:
538:
537:
530:
527:
526:
525:
501:
498:
497:
496:
488:
478:
470:
460:
448:
438:
437:Approved drugs
435:
433:
430:
429:
428:
415:
397:
384:
370:
348:
330:
312:
298:
292:
289:
288:
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263:
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128:
125:
117:
111:
105:
100:
90:
87:
86:
85:
75:
72:
71:
70:
58:
53:Immunoglobulin
48:
45:
43:
40:
13:
10:
9:
6:
4:
3:
2:
1192:
1181:
1178:
1176:
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1154:
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1146:
1142:
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1111:
1104:
1099:
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1019:
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1012:
1007:
1006:
1003:
997:
994:
993:
989:
983:
979:
974:
969:
964:
959:
955:
951:
947:
942:
938:
934:
929:
924:
920:
916:
912:
907:
903:
899:
895:
891:
887:
883:
878:
877:
873:
864:
860:
855:
850:
846:
842:
838:
834:
830:
823:
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815:
811:
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799:
795:
791:
787:
780:
777:
772:
768:
764:
760:
756:
752:
748:
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737:
734:
729:
725:
721:
717:
713:
709:
702:
699:
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690:
686:
682:
678:
674:
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666:
665:Curr Med Chem
659:
656:
651:
647:
642:
637:
633:
629:
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610:
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601:
596:
591:
586:
582:
578:
574:
567:
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563:
561:
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547:
540:
536:
533:
532:
528:
523:
519:
515:
511:
507:
504:
503:
499:
495:
492:
489:
487:
485:
482:
479:
477:
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471:
469:
467:
464:
461:
459:
456:
452:
449:
447:
444:
441:
440:
436:
431:
427:
425:
419:
416:
413:
409:
405:
401:
398:
396:
392:
388:
385:
382:
378:
374:
371:
368:
364:
363:nitrous oxide
360:
356:
352:
349:
346:
342:
338:
334:
331:
328:
324:
320:
316:
315:Antiandrogens
313:
310:
306:
302:
295:
294:
290:
286:
275:
272:
270:
267:
264:
262:
255:
252:
250:
243:
240:
238:
235:
232:
230:
227:
224:
222:
219:
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205:
202:
191:
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179:
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158:
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149:
146:
143:
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138:
135:
133:
126:
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118:
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109:
106:
104:
101:
99:
96:
93:
92:
88:
84:
81:
78:
77:
73:
69:
66:
62:
59:
57:
54:
51:
50:
46:
41:
39:
36:
35:
31:
29:
25:
21:
16:
1141:aripiprazole
1110:clomipramine
1064:escitalopram
953:
949:
921:(4): 455–8.
918:
914:
885:
881:
836:
832:
822:
789:
785:
779:
746:
742:
736:
711:
707:
701:
668:
664:
658:
631:
627:
617:
580:
576:
510:aripiprazole
454:
451:Escitalopram
443:Clomipramine
423:
389:(Rituxan) –
333:Cannabinoids
37:
33:
32:
19:
17:
15:
1153:risperidone
1131:haloperidol
1095:venlafaxine
1072:fluvoxamine
956:: 695–706.
839:(1): e128.
583:: 695–706.
522:risperidone
473:Fluvoxamine
420:(Tasmar) –
327:triptorelin
242:Ondansetron
226:Mavoglurant
178:Cycloserine
137:Risperidone
108:Agomelatine
61:Troriluzole
1169:Categories
1149:quetiapine
1145:olanzapine
1080:sertraline
1076:paroxetine
1068:fluoxetine
1060:citalopram
792:: 113093.
541:References
518:quetiapine
514:olanzapine
491:Sertraline
481:Paroxetine
463:Fluoxetine
404:psilocybin
367:rapastinel
309:WAY-208466
305:WAY-181187
170:Bitopertin
18:This is a
814:229690041
771:226217912
693:208956450
422:catechol-
418:Tolcapone
387:Rituximab
377:celecoxib
359:memantine
319:flutamide
274:SB-200646
266:Roxindole
254:RO-600175
190:Elzasonan
982:33447096
937:25599971
902:18704978
863:33884324
806:33359368
763:33125716
728:17196053
685:31814547
650:17625499
609:33447096
529:See also
393:against
381:naproxen
355:ketamine
345:cannabis
337:nabilone
280:and 5-HT
234:NPL-2003
210:and 5-HT
196:and 5-HT
145:Secretin
65:riluzole
973:7801912
854:8055489
600:7801912
508:(e.g.,
402:(e.g.,
353:(e.g.,
335:(e.g.,
317:(e.g.,
303:(e.g.,
204:F-14258
120:CR-5542
1120:Others
980:
970:
935:
900:
861:
851:
812:
804:
769:
761:
726:
691:
683:
648:
607:
597:
343:(THC)/
1087:SNRIs
1052:SSRIs
810:S2CID
767:S2CID
689:S2CID
24:drugs
22:, or
1102:TCAs
978:PMID
933:PMID
898:PMID
859:PMID
802:PMID
759:PMID
724:PMID
681:PMID
646:PMID
605:PMID
395:CD20
297:5-HT
1033:OCD
968:PMC
958:doi
923:doi
890:doi
849:PMC
841:doi
794:doi
790:401
751:doi
747:143
716:doi
673:doi
636:doi
595:PMC
585:doi
1171::
1151:,
1147:,
1143:,
1078:,
1074:,
1070:,
1066:,
1062:,
976:.
966:.
954:12
952:.
948:.
931:.
919:24
917:.
913:.
896:.
886:75
884:.
857:.
847:.
835:.
831:.
808:.
800:.
788:.
765:.
757:.
745:.
722:.
712:67
710:.
687:.
679:.
669:27
667:.
644:.
632:33
630:.
626:.
603:.
593:.
581:12
579:.
575:.
549:^
520:,
516:,
512:,
410:,
379:,
365:,
361:,
357:,
339:,
325:,
321:,
307:,
282:2C
278:2B
258:2C
212:1D
208:1B
198:1D
194:1B
129:1A
112:2C
1155:)
1139:(
1133:)
1129:(
1112:)
1108:(
1097:)
1093:(
1082:)
1058:(
1024:e
1017:t
1010:v
984:.
960::
939:.
925::
904:.
892::
865:.
843::
837:6
816:.
796::
773:.
753::
730:.
718::
695:.
675::
652:.
638::
611:.
587::
455:S
453:(
424:O
406:/
369:)
329:)
311:)
299:6
246:3
182:D
180:(
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