1459:"There is an enormous need for novel non-opioid analgesics with no abuse liability," and Vertex's results are an "important advance," said Dr. Clifford J. Woolf, director of the F.M. Kirby Neurobiology Center and Boston Children's Hospital. It will be important for Vertex to determine whether the drug also works for patients with chronic pain, such as diabetic neuropathy and low back pain, "where the clinical need is highest," he added.
24:
1471:
Manitpisitkul, Prasarn; Shalayda, Kevin; Russell, Lucille; Sanga, Panna; Solanki, Bhavna; Caruso, Joseph; Iwaki, Yuki; Moyer, John A. (10 November 2017). "Pharmacokinetics and Safety of
Mavatrep (JNJ-39439335), a TRPV1 Antagonist in Healthy Japanese and Caucasian Men: A Double-Blind, Randomized,
1531:
Manitpisitkul, Prasarn; Shalayda, Kevin; Russell, Lucille; Sanga, Panna; Williams, Yinka; Solanki, Bhavna; Caruso, Joseph; Moyer, John A. (2018). "Bioavailability and
Pharmacokinetics of TRPV1 Antagonist Mavatrep (JNJ-39439335) Tablet and Capsule Formulations in Healthy Men: Two Open-Label,
1404:
Vertex
Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced that it has begun a Phase 2 proof-of-concept (POC) study in acute pain following bunionectomy surgery with the selective NaV1.8 inhibitor VX-548 and that it expects to commence a second Phase 2 study in acute pain following
3127:
3120:
1446:
3113:
1227:
Nakamura, Michiko; Shin, Hyewon; Jang, Il-Sung (26 April 2018). "Mechanism of Action of
Cenobamate: Preferential Inhibition of the Persistent Sodium Current (P5.278)".
3159:
1385:
1419:
700:
3071:
1679:
2687:
2248:
2216:
152:
63:
1303:
1131:
1043:
1009:
975:
945:
915:
885:
1342:
1312:
1140:
1082:
1052:
1014:
980:
1589:
3204:
1164:
859:
2543:
2186:
316:
3449:
3444:
3088:
2206:
1583:
Moreno, Ana M.; Alemán, Fernando; Catroli, Glaucilene F.; Hunt, Matthew; Hu, Michael; et al. (10 March 2021).
1173:
3285:
3178:
1308:
720:
85:
Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
3362:
2921:
2882:
1672:
335:(formerly raxatrigine; CNV1014802, GSK-1014802, BIIB 074) – non-selective voltage-gated sodium channel blocker
41:
34:
3076:
2792:
2196:
1852:
1162:
Zaccara, Gaetano; Schmidt, D. (2017). "Antiepileptic Drugs in
Clinical Development: Differentiate or Die?".
794:
523:
2840:
1929:
1796:
1390:
403:
221:
176:
103:
95:
2599:
2293:
2211:
2201:
1913:
1856:
3105:
2810:
2771:
2604:
2594:
2589:
2416:
2221:
2137:
1779:
767:
537:
148:
132:
111:
107:
99:
3439:
3228:
3143:
2559:
2191:
2020:
1921:
1860:
1747:
1736:
1665:
1229:
667:
648:
377:
124:
114:
2228:
458:
2997:
2564:
2462:
2133:
1991:
1925:
1606:
1565:
1513:
1489:
1358:
1278:
1246:
1209:
1185:
1098:
504:
419:
166:
747:
716:
496:
83:, or analgesics that are currently under development for clinical use but are not yet approved.
2176:
678:
480:
442:
3334:
3324:
2781:
2636:
2624:
2511:
1917:
1632:
1614:
1557:
1549:
1505:
1497:
1438:
1430:
1270:
1262:
1254:
1201:
1193:
818:
729:
609:
519:
472:
288:
276:
264:
189:
826:
782:
763:
696:
663:
555:
415:
210:
3370:
3270:
3136:
2858:
2332:
1622:
1598:
1541:
1481:
1425:
1386:"Vertex Initiates Phase 2 Clinical Trial Program for VX-548 for the Treatment of Acute Pain"
1238:
1177:
844:
810:
740:
689:
526:
340:
838:
327:(9401-TTX; Tectin, Tetrodin, Tocudin) – non-selective voltage-gated sodium channel blocker
3348:
3042:
2961:
2943:
2756:
2521:
2506:
2447:
1830:
1731:
1370:
1110:
488:
407:
170:
156:
135:
725:
1242:
3414:
3236:
3082:
3037:
2800:
2680:
2655:
2531:
2516:
1986:
1866:
1817:
1784:
1627:
1584:
708:
704:
547:
193:
179:– combination of a μ-opioid receptor agonist and a μ- and κ-opioid receptor antagonist.
45:
1181:
751:
3433:
3400:
3298:
3294:
3256:
3252:
3191:
3187:
3151:
2971:
2966:
2956:
2886:
2848:
2306:
2081:
2011:
1871:
1840:
1789:
140:
1569:
1517:
1282:
3329:
3140:
2976:
2951:
2709:
2614:
2498:
2285:
2273:
2263:
2238:
2106:
2096:
2026:
1901:
1896:
1807:
1696:
1692:
1335:
1297:
1213:
1125:
1075:
1037:
1003:
969:
939:
834:
430:
423:
324:
128:
120:
909:
879:
848:
822:
814:
802:
786:
771:
759:
743:
723:
712:
692:
674:
659:
651:
633:
621:
605:
589:
587:
567:
551:
543:
541:
529:
508:
500:
492:
484:
476:
462:
454:
446:
438:
411:
399:
348:
336:
328:
320:
308:
292:
284:
272:
1602:
3384:
3344:
3302:
3264:
3248:
3172:
3022:
3002:
2911:
2820:
2751:
2743:
2704:
2629:
2579:
2574:
2473:
2409:
2337:
2181:
2166:
2157:
2091:
2076:
2071:
2061:
2056:
2051:
2001:
1981:
1976:
1971:
1940:
1935:
1891:
1876:
1845:
1824:
1802:
1420:"Vertex's non-opioid painkiller shows promise in people recovering from surgery"
533:
332:
312:
296:
40:
The references used may be made clearer with a different or consistent style of
758:(PF-4383119, RI-624, RN-624) – monoclonal antibody against nerve growth factor
3408:
3352:
3308:
3280:
3260:
3244:
3240:
3213:
3168:
3052:
3047:
2992:
2929:
2872:
2853:
2830:
2825:
2815:
2805:
2766:
2729:
2724:
2719:
2670:
2665:
2647:
2584:
2569:
2554:
2488:
2468:
2399:
2389:
2358:
2312:
2299:
2268:
2233:
2116:
2111:
2086:
2036:
2031:
2006:
1961:
1886:
655:
571:
226:
1618:
1610:
1553:
1501:
1493:
1434:
1274:
1258:
1250:
1197:
1189:
3396:
3392:
3374:
3339:
3274:
3195:
3057:
3017:
3012:
2866:
2714:
2675:
2619:
2549:
2483:
2478:
2455:
2437:
2422:
2394:
2373:
2368:
2363:
2322:
2278:
2066:
2041:
1906:
1835:
1763:
1688:
1442:
755:
644:
391:
79:
1636:
1561:
1509:
1205:
1657:
1585:"Long-lasting analgesia via targeted in situ repression of NaV1.7 in mice"
658:(AMG-403, JNJ-42160443) – monoclonal antibody against nerve growth factor
3404:
3388:
3366:
3356:
3217:
3027:
2906:
2901:
2761:
2660:
2432:
2427:
2404:
2353:
2327:
2317:
2126:
2121:
2101:
2016:
1996:
1945:
1758:
1743:
1136:
625:
593:
466:
450:
369:
250:
232:
3032:
3007:
2877:
2862:
2609:
2539:
2171:
2143:
1966:
1881:
1726:
806:
790:
3380:
3201:
1812:
1714:
1705:
1545:
1485:
1048:
352:
240:
214:
200:
3160:
1652:
750:(NV-01) – monoclonal antibody against nerve growth factor for dogs
2046:
1753:
1718:
830:
395:
1266:
737:
733:
686:
682:
671:
3109:
1661:
17:
229:(YKP-3089) – atypical voltage-gated sodium channel blocker.
3205:
1472:
Placebo-Controlled, Sequential-Group Phase 1 Study".
647:(REGN-475, SAR-164877) – monoclonal antibody against
383:
3317:
3227:
3165:
Tooltip
Serotonin–norepinephrine reuptake inhibitor
3150:
2985:
2942:
2920:
2839:
2791:
2780:
2742:
2697:
2646:
2530:
2497:
2446:
2382:
2346:
2256:
2247:
2156:
1954:
1772:
1713:
1704:
550:(CBDV; GWP-42006) – cannabinoid receptor modulator
1418:
1334:
1296:
1124:
1074:
1036:
1002:
968:
938:
908:
878:
3286:
3179:
123:(GRT-6005) – non-selective μ-opioid receptor,
3416:
3121:
1673:
8:
1081:. Chromocell Corporation. 28 November 2019.
575:
394:(Adlea, ALGRX-4975, CNTX-4975, VLNX-4975) –
1405:abdominoplasty surgery in the coming weeks.
1341:. Xenon Pharmaceuticals. 6 September 2022.
376:δ subunit of voltage-gated calcium channel
3128:
3114:
3106:
2788:
2253:
1710:
1680:
1666:
1658:
1626:
1534:Clinical Pharmacology in Drug Development
1532:Crossover, Single-Dose Phase 1 Studies".
1474:Clinical Pharmacology in Drug Development
64:Learn how and when to remove this message
1013:. Elite Pharmaceuticals. 16 April 2021.
372: – selective ligand of α
870:
406:– combination of a TRPV1 agonist and a
291:– voltage-gated sodium channel blocker
1366:
1356:
1106:
1096:
889:. Theravance Biopharma. 1 October 2021
169:(GRT-6006, GRT13106G) – non-selective
3210:Tooltip monoamine reuptake inhibitors
1345:from the original on 14 November 2022
1315:from the original on 14 November 2022
1143:from the original on 14 November 2022
1055:from the original on 14 November 2022
1017:from the original on 14 November 2022
1004:"Drug profile | Oxycodone/naltrexone"
983:from the original on 25 December 2018
7:
949:. Syntrix Biosystems. 5 October 2021
880:"Drug profile | Axelopran/oxycodone"
766:– selective, peripherally selective
192:– state-dependent and use-dependent
98:– combination of a centrally active
1243:10.1212/WNL.90.15_supplement.P5.278
1085:from the original on 15 March 2022
469:(JNJ‐39439335) – TRPV1 antagonist.
319:blocker, as well as other actions
14:
3291:Tooltip Tricyclic antidepressants
3184:Tooltip Tricyclic antidepressants
2772:Tetrahydrocannabinol (dronabinol)
1384:Nichols, Heather (19 July 2021).
1182:10.2174/1381612823666170809100524
253:(TV-45070, XEN402) – selective Na
153:norepinephrine reuptake inhibitor
1449:from the original on 19 May 2022
847:– undefined mechanism of action
831:nicotinic acetylcholine receptor
821:– undefined mechanism of action
785:– undefined mechanism of action
147:-desmethyltramadol; Omnitram) –
22:
732:– peripherally selective TrkA,
558:– TRPV1 modulator as well as CB
514:Cannabinoid receptor modulators
491:(RTX; MCP-101) – TRPV1 agonist
2540:Aspirin (acetylsalicylic acid)
1590:Science Translational Medicine
940:"Drug profile | Desmetramadol"
639:Nerve growth factor inhibitors
507:(SYL-1001) – TRPV1 antagonist
483:(DD-04107) – TRPV1 antagonist
1:
1417:Cross, Ryan (31 March 2022).
1165:Current Pharmaceutical Design
919:. Tris Pharma. 14 August 2022
910:"Drug profile | Cebranopadol"
860:List of investigational drugs
1603:10.1126/scitranslmed.aay9056
970:"Drug profile | Lexanopadol"
317:voltage-gated sodium channel
2182:Paracetamol (acetaminophen)
1126:"Drug profile | Cenobamate"
841:– CRISPR-dCas9 gene-editing
3466:
1174:Bentham Science Publishers
445:(TR-1) – TRPV1 antagonist
315:(NW-1029) – non-selective
90:Opioid receptor modulators
3363:NMDA receptor antagonists
3066:
2883:Tricyclic antidepressants
1309:Sumitomo Dainippon Pharma
1298:"Drug profile | DSP 2230"
1038:"Drug profile | BIIB 095"
721:tyrosine kinase modulator
2217:+propyphenazone/caffeine
711:for nerve growth factor
578:; ECP022A, Namisol) – CB
410:for topical application
364:Calcium channel blockers
279:(RG-6029) – selective Na
267:(RG-7893) – selective Na
127:, and δ-opioid receptor
78:list of investigational
1337:Drug profile | Funapide
524:monoacylglycerol lipase
213:(ASP-1807) – selective
184:Sodium channel blockers
2067:Pethidine (meperidine)
1653:AdisInsight - Springer
1391:Vertex Pharmaceuticals
1077:Drug profile | CC 8464
809:(MR-309; S1A; S1RA) –
104:peripherally selective
2688:+paracetamol/caffeine
2666:Metamizole (dipyrone)
2600:Morpholine salicylate
2544:+paracetamol/caffeine
1137:SK biopharmaceuticals
3229:Ion channel blockers
2811:Gabapentin enacarbil
2605:Potassium salicylate
2595:Magnesium salicylate
2590:Imidazole salicylate
2417:Indometacin farnesil
1813:Diamorphine (heroin)
1780:Acetyldihydrocodeine
1139:. 28 November 2019.
768:allosteric inhibitor
538:cannabinoid receptor
404:Capsaicin/diclofenac
177:Oxycodone/naltrexone
2560:Carbasalate calcium
668:monoclonal antibody
649:nerve growth factor
566:receptor modulator
499:– TRPV1 antagonist
475:– TRPV1 antagonist
461:– TRPV1 antagonist
199:blocker, including
125:nociceptin receptor
96:Axelopran/oxycodone
3450:Experimental drugs
3445:Drug-related lists
3093:Never to phase III
2998:Analgesic adjuvant
2899:1.7/1.8-selective:
2565:Choline salicylate
1992:Dextropropoxyphene
979:. 20 August 2018.
386:channel modulators
3427:
3426:
3335:Botulinum toxin A
3325:Alpha lipoic acid
3271:Local anesthetics
3144:pharmacotherapies
3103:
3102:
2938:
2937:
2922:Potassium openers
2859:Local anesthetics
2801:Alcohol (ethanol)
2738:
2737:
2637:methyl salicylate
2625:Sodium salicylate
2512:Meclofenamic acid
2187:+aspirin/caffeine
2152:
2151:
1237:(15 Supplement).
632:receptor agonist
620:receptor agonist
604:receptor agonist
586:receptor agonist
149:μ-opioid receptor
133:κ-opioid receptor
112:δ-opioid receptor
100:μ-opioid receptor
74:
73:
66:
3457:
3418:
3415:Sodium oxybate (
3371:dextromethorphan
3292:
3288:
3211:
3207:
3185:
3181:
3166:
3162:
3137:Neuropathic pain
3130:
3123:
3116:
3107:
2793:Calcium blockers
2789:
2685:
2634:
2460:
2448:COX-2 inhibitors
2414:
2333:Tiaprofenic acid
2304:
2291:
2283:
2254:
2131:
1911:
1850:
1822:
1794:
1711:
1682:
1675:
1668:
1659:
1641:
1640:
1630:
1580:
1574:
1573:
1546:10.1002/cpdd.412
1528:
1522:
1521:
1486:10.1002/cpdd.413
1468:
1462:
1461:
1456:
1454:
1426:The Boston Globe
1422:
1414:
1408:
1407:
1401:
1399:
1381:
1375:
1374:
1368:
1364:
1362:
1354:
1352:
1350:
1340:
1331:
1325:
1324:
1322:
1320:
1311:. 4 April 2022.
1300:
1293:
1287:
1286:
1224:
1218:
1217:
1159:
1153:
1152:
1150:
1148:
1128:
1121:
1115:
1114:
1108:
1104:
1102:
1094:
1092:
1090:
1080:
1071:
1065:
1064:
1062:
1060:
1040:
1033:
1027:
1026:
1024:
1022:
1006:
999:
993:
992:
990:
988:
972:
965:
959:
958:
956:
954:
942:
935:
929:
928:
926:
924:
912:
905:
899:
898:
896:
894:
882:
875:
811:sigma-1 receptor
741:kinase inhibitor
690:kinase inhibitor
577:
453:– TRPV1 agonist
385:
69:
62:
58:
55:
49:
26:
25:
18:
3465:
3464:
3460:
3459:
3458:
3456:
3455:
3454:
3430:
3429:
3428:
3423:
3313:
3290:
3237:Anticonvulsants
3223:
3209:
3183:
3164:
3146:
3134:
3104:
3099:
3098:
3083:Clinical trials
3062:
3043:Phenazopyridine
2981:
2962:Cyclobenzaprine
2934:
2916:
2898:
2841:Sodium blockers
2835:
2783:
2776:
2734:
2693:
2683:
2642:
2632:
2526:
2522:Tolfenamic acid
2507:Flufenamic acid
2493:
2458:
2442:
2412:
2378:
2342:
2302:
2289:
2281:
2243:
2207:+metoclopramide
2148:
2129:
1950:
1909:
1848:
1831:Dihydromorphine
1820:
1792:
1768:
1700:
1686:
1649:
1644:
1582:
1581:
1577:
1530:
1529:
1525:
1470:
1469:
1465:
1452:
1450:
1416:
1415:
1411:
1397:
1395:
1394:(Press Release)
1383:
1382:
1378:
1365:
1355:
1348:
1346:
1333:
1332:
1328:
1318:
1316:
1295:
1294:
1290:
1226:
1225:
1221:
1161:
1160:
1156:
1146:
1144:
1123:
1122:
1118:
1105:
1095:
1088:
1086:
1073:
1072:
1068:
1058:
1056:
1035:
1034:
1030:
1020:
1018:
1001:
1000:
996:
986:
984:
967:
966:
962:
952:
950:
937:
936:
932:
922:
920:
907:
906:
902:
892:
890:
877:
876:
872:
868:
856:
798:
779:
641:
631:
619:
615:
603:
599:
585:
581:
565:
561:
516:
489:Resiniferatoxin
434:
427:
408:COX-2 inhibitor
388:
375:
366:
358:
346:
306:
302:
282:
270:
260:
256:
244:
238:
218:
204:
197:
186:
171:opioid receptor
160:
136:partial agonist
92:
70:
59:
53:
50:
39:
33:has an unclear
27:
23:
12:
11:
5:
3463:
3461:
3453:
3452:
3447:
3442:
3432:
3431:
3425:
3424:
3422:
3421:
3412:
3378:
3360:
3342:
3337:
3332:
3327:
3321:
3319:
3315:
3314:
3312:
3311:
3306:
3283:
3278:
3268:
3233:
3231:
3225:
3224:
3222:
3221:
3199:
3176:
3156:
3154:
3152:Monoaminergics
3148:
3147:
3135:
3133:
3132:
3125:
3118:
3110:
3101:
3100:
3097:
3096:
3095:
3094:
3091:
3080:
3074:
3068:
3067:
3064:
3063:
3061:
3060:
3055:
3050:
3045:
3040:
3038:Methoxyflurane
3035:
3030:
3025:
3020:
3015:
3010:
3005:
3000:
2995:
2989:
2987:
2983:
2982:
2980:
2979:
2974:
2969:
2964:
2959:
2954:
2948:
2946:
2940:
2939:
2936:
2935:
2933:
2932:
2926:
2924:
2918:
2917:
2915:
2914:
2909:
2904:
2896:
2891:
2890:
2880:
2875:
2870:
2856:
2851:
2845:
2843:
2837:
2836:
2834:
2833:
2828:
2823:
2818:
2813:
2808:
2803:
2797:
2795:
2786:
2778:
2777:
2775:
2774:
2769:
2764:
2759:
2754:
2748:
2746:
2740:
2739:
2736:
2735:
2733:
2732:
2727:
2722:
2717:
2712:
2707:
2701:
2699:
2695:
2694:
2692:
2691:
2681:Propyphenazone
2678:
2673:
2668:
2663:
2658:
2656:Aminophenazone
2652:
2650:
2644:
2643:
2641:
2640:
2627:
2622:
2617:
2612:
2607:
2602:
2597:
2592:
2587:
2582:
2577:
2572:
2567:
2562:
2557:
2552:
2547:
2536:
2534:
2528:
2527:
2525:
2524:
2519:
2517:Mefenamic acid
2514:
2509:
2503:
2501:
2495:
2494:
2492:
2491:
2486:
2481:
2476:
2471:
2466:
2452:
2450:
2444:
2443:
2441:
2440:
2435:
2430:
2425:
2420:
2407:
2402:
2397:
2392:
2386:
2384:
2380:
2379:
2377:
2376:
2371:
2366:
2361:
2356:
2350:
2348:
2344:
2343:
2341:
2340:
2335:
2330:
2325:
2320:
2315:
2310:
2297:
2276:
2271:
2266:
2260:
2258:
2251:
2245:
2244:
2242:
2241:
2236:
2231:
2226:
2225:
2224:
2219:
2214:
2209:
2204:
2199:
2194:
2189:
2179:
2174:
2169:
2163:
2161:
2154:
2153:
2150:
2149:
2147:
2146:
2141:
2124:
2119:
2114:
2109:
2104:
2099:
2094:
2089:
2084:
2079:
2074:
2069:
2064:
2059:
2054:
2049:
2044:
2039:
2034:
2029:
2024:
2014:
2009:
2004:
1999:
1994:
1989:
1987:Dextromoramide
1984:
1979:
1974:
1969:
1964:
1958:
1956:
1952:
1951:
1949:
1948:
1943:
1938:
1933:
1904:
1899:
1894:
1889:
1884:
1879:
1874:
1869:
1867:Hydromorphinol
1864:
1843:
1838:
1833:
1828:
1818:Dihydrocodeine
1815:
1810:
1805:
1800:
1787:
1785:Benzylmorphine
1782:
1776:
1774:
1770:
1769:
1767:
1766:
1761:
1756:
1751:
1741:
1740:
1739:
1734:
1723:
1721:
1708:
1702:
1701:
1687:
1685:
1684:
1677:
1670:
1662:
1656:
1655:
1648:
1647:External links
1645:
1643:
1642:
1575:
1540:(7): 699–711.
1523:
1480:(7): 712–726.
1463:
1409:
1376:
1326:
1288:
1219:
1154:
1116:
1066:
1051:. 7 May 2021.
1028:
994:
960:
930:
900:
869:
867:
864:
863:
862:
855:
852:
851:
850:
842:
836:
824:
816:
804:
796:
788:
778:
775:
774:
773:
761:
753:
745:
727:
714:
709:decoy receptor
705:fusion protein
694:
676:
661:
653:
640:
637:
636:
635:
629:
628:(APD-371) – CB
623:
617:
613:
607:
601:
597:
591:
583:
579:
569:
563:
559:
553:
548:Cannabidivarin
545:
531:
515:
512:
511:
510:
502:
494:
486:
478:
470:
464:
456:
448:
440:
432:
425:
413:
401:
387:
381:
380:
379:
373:
365:
362:
361:
360:
356:
355:– selective Na
350:
344:
343:– selective Na
338:
330:
322:
310:
304:
300:
299:– selective Na
294:
286:
280:
274:
268:
262:
258:
254:
248:
242:
236:
235:– selective Na
230:
224:
216:
208:
202:
195:
185:
182:
181:
180:
174:
164:
158:
138:
118:
102:agonist and a
91:
88:
72:
71:
35:citation style
30:
28:
21:
13:
10:
9:
6:
4:
3:
2:
3462:
3451:
3448:
3446:
3443:
3441:
3438:
3437:
3435:
3420:
3413:
3410:
3406:
3402:
3401:buprenorphine
3398:
3394:
3390:
3386:
3382:
3379:
3376:
3372:
3368:
3364:
3361:
3358:
3354:
3350:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3322:
3320:
3316:
3310:
3307:
3304:
3300:
3299:nortriptyline
3296:
3295:amitriptyline
3289:
3284:
3282:
3279:
3276:
3272:
3269:
3266:
3262:
3258:
3257:oxcarbazepine
3254:
3253:carbamazepine
3250:
3246:
3242:
3238:
3235:
3234:
3232:
3230:
3226:
3219:
3215:
3208:
3203:
3200:
3197:
3193:
3192:nortriptyline
3189:
3188:amitriptyline
3182:
3177:
3174:
3170:
3163:
3158:
3157:
3155:
3153:
3149:
3145:
3142:
3138:
3131:
3126:
3124:
3119:
3117:
3112:
3111:
3108:
3092:
3090:
3087:
3086:
3084:
3081:
3078:
3075:
3073:
3070:
3069:
3065:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2999:
2996:
2994:
2991:
2990:
2988:
2984:
2978:
2975:
2973:
2972:Methocarbamol
2970:
2968:
2967:Mephenoxalone
2965:
2963:
2960:
2958:
2957:Chlorzoxazone
2955:
2953:
2950:
2949:
2947:
2945:
2941:
2931:
2928:
2927:
2925:
2923:
2919:
2913:
2910:
2908:
2905:
2903:
2900:
2893:
2892:
2888:
2887:amitriptyline
2884:
2881:
2879:
2876:
2874:
2871:
2868:
2864:
2860:
2857:
2855:
2852:
2850:
2849:Carbamazepine
2847:
2846:
2844:
2842:
2838:
2832:
2829:
2827:
2824:
2822:
2819:
2817:
2814:
2812:
2809:
2807:
2804:
2802:
2799:
2798:
2796:
2794:
2790:
2787:
2785:
2779:
2773:
2770:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2750:
2749:
2747:
2745:
2741:
2731:
2728:
2726:
2723:
2721:
2718:
2716:
2713:
2711:
2708:
2706:
2703:
2702:
2700:
2696:
2689:
2682:
2679:
2677:
2674:
2672:
2669:
2667:
2664:
2662:
2659:
2657:
2654:
2653:
2651:
2649:
2645:
2638:
2631:
2628:
2626:
2623:
2621:
2618:
2616:
2613:
2611:
2608:
2606:
2603:
2601:
2598:
2596:
2593:
2591:
2588:
2586:
2583:
2581:
2578:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2545:
2541:
2538:
2537:
2535:
2533:
2529:
2523:
2520:
2518:
2515:
2513:
2510:
2508:
2505:
2504:
2502:
2500:
2496:
2490:
2487:
2485:
2482:
2480:
2477:
2475:
2472:
2470:
2467:
2464:
2457:
2454:
2453:
2451:
2449:
2445:
2439:
2436:
2434:
2431:
2429:
2426:
2424:
2421:
2418:
2411:
2408:
2406:
2403:
2401:
2398:
2396:
2393:
2391:
2388:
2387:
2385:
2381:
2375:
2372:
2370:
2367:
2365:
2362:
2360:
2357:
2355:
2352:
2351:
2349:
2345:
2339:
2336:
2334:
2331:
2329:
2326:
2324:
2321:
2319:
2316:
2314:
2311:
2308:
2307:Dexketoprofen
2301:
2298:
2295:
2287:
2280:
2277:
2275:
2272:
2270:
2267:
2265:
2262:
2261:
2259:
2255:
2252:
2250:
2246:
2240:
2237:
2235:
2232:
2230:
2227:
2223:
2220:
2218:
2215:
2213:
2210:
2208:
2205:
2203:
2200:
2198:
2195:
2193:
2190:
2188:
2185:
2184:
2183:
2180:
2178:
2175:
2173:
2170:
2168:
2165:
2164:
2162:
2159:
2155:
2145:
2142:
2139:
2135:
2128:
2125:
2123:
2120:
2118:
2115:
2113:
2110:
2108:
2105:
2103:
2100:
2098:
2095:
2093:
2090:
2088:
2085:
2083:
2082:Phenoperidine
2080:
2078:
2075:
2073:
2070:
2068:
2065:
2063:
2060:
2058:
2055:
2053:
2050:
2048:
2045:
2043:
2040:
2038:
2035:
2033:
2030:
2028:
2025:
2022:
2018:
2015:
2013:
2012:Ethoheptazine
2010:
2008:
2005:
2003:
2000:
1998:
1995:
1993:
1990:
1988:
1985:
1983:
1980:
1978:
1975:
1973:
1970:
1968:
1965:
1963:
1960:
1959:
1957:
1953:
1947:
1944:
1942:
1939:
1937:
1934:
1931:
1927:
1923:
1919:
1915:
1908:
1905:
1903:
1900:
1898:
1895:
1893:
1890:
1888:
1885:
1883:
1880:
1878:
1875:
1873:
1872:Hydromorphone
1870:
1868:
1865:
1862:
1858:
1854:
1847:
1844:
1842:
1841:Ethylmorphine
1839:
1837:
1834:
1832:
1829:
1826:
1819:
1816:
1814:
1811:
1809:
1806:
1804:
1801:
1798:
1791:
1790:Buprenorphine
1788:
1786:
1783:
1781:
1778:
1777:
1775:
1773:Semisynthetic
1771:
1765:
1762:
1760:
1757:
1755:
1752:
1749:
1745:
1742:
1738:
1735:
1733:
1730:
1729:
1728:
1725:
1724:
1722:
1720:
1716:
1712:
1709:
1707:
1703:
1698:
1694:
1690:
1683:
1678:
1676:
1671:
1669:
1664:
1663:
1660:
1654:
1651:
1650:
1646:
1638:
1634:
1629:
1624:
1620:
1616:
1612:
1608:
1604:
1600:
1596:
1592:
1591:
1586:
1579:
1576:
1571:
1567:
1563:
1559:
1555:
1551:
1547:
1543:
1539:
1535:
1527:
1524:
1519:
1515:
1511:
1507:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1475:
1467:
1464:
1460:
1448:
1444:
1440:
1436:
1432:
1428:
1427:
1421:
1413:
1410:
1406:
1393:
1392:
1387:
1380:
1377:
1372:
1360:
1344:
1339:
1338:
1330:
1327:
1314:
1310:
1306:
1305:
1299:
1292:
1289:
1284:
1280:
1276:
1272:
1268:
1264:
1260:
1256:
1252:
1248:
1244:
1240:
1236:
1232:
1231:
1223:
1220:
1215:
1211:
1207:
1203:
1199:
1195:
1191:
1187:
1183:
1179:
1176:: 5593–5605.
1175:
1171:
1167:
1166:
1158:
1155:
1142:
1138:
1134:
1133:
1127:
1120:
1117:
1112:
1100:
1084:
1079:
1078:
1070:
1067:
1054:
1050:
1046:
1045:
1039:
1032:
1029:
1016:
1012:
1011:
1005:
998:
995:
982:
978:
977:
971:
964:
961:
948:
947:
941:
934:
931:
918:
917:
911:
904:
901:
888:
887:
881:
874:
871:
865:
861:
858:
857:
853:
849:
846:
843:
840:
837:
835:
832:
828:
825:
823:
820:
817:
815:
812:
808:
805:
803:
800:
795:imidazoline I
792:
789:
787:
784:
781:
780:
776:
772:
769:
765:
762:
760:
757:
754:
752:
749:
746:
744:
742:
739:
735:
731:
728:
726:
724:
722:
718:
715:
713:
710:
706:
702:
701:LNGF receptor
698:
695:
693:
691:
688:
684:
680:
677:
675:
673:
669:
665:
662:
660:
657:
654:
652:
650:
646:
643:
642:
638:
634:
627:
624:
622:
611:
608:
606:
595:
592:
590:
588:
573:
570:
568:
557:
554:
552:
549:
546:
544:
542:
539:
535:
532:
530:
528:
525:
521:
518:
517:
513:
509:
506:
503:
501:
498:
495:
493:
490:
487:
485:
482:
479:
477:
474:
471:
468:
465:
463:
460:
457:
455:
452:
449:
447:
444:
441:
439:
436:
428:
421:
417:
414:
412:
409:
405:
402:
400:
397:
393:
390:
389:
382:
378:
371:
368:
367:
363:
354:
351:
349:
342:
339:
337:
334:
331:
329:
326:
323:
321:
318:
314:
311:
309:
298:
295:
293:
290:
287:
285:
278:
275:
273:
266:
263:
252:
249:
246:
234:
231:
228:
225:
223:
220:
212:
209:
206:
198:
191:
188:
187:
183:
178:
175:
172:
168:
165:
162:
154:
150:
146:
142:
141:Desmetramadol
139:
137:
134:
130:
126:
122:
119:
116:
113:
109:
105:
101:
97:
94:
93:
89:
87:
86:
82:
81:
68:
65:
57:
47:
43:
37:
36:
31:This article
29:
20:
19:
16:
3345:Cannabinoids
3330:Benfotiamine
3141:fibromyalgia
2977:Orphenadrine
2952:Carisoprodol
2944:Myorelaxants
2894:
2744:Cannabinoids
2710:Floctafenine
2615:Salicylamide
2294:+paracetamol
2286:Dexibuprofen
2274:Flurbiprofen
2264:Benoxaprofen
2239:Propacetamol
2229:Parapropamol
2197:+hydrocodone
2138:+paracetamol
2107:Remifentanil
2097:Proheptazine
2027:Ketobemidone
1967:Alphaprodine
1914:+paracetamol
1902:Nicomorphine
1897:Nicodicodine
1853:+paracetamol
1825:+paracetamol
1808:Desomorphine
1737:+paracetamol
1594:
1588:
1578:
1537:
1533:
1526:
1477:
1473:
1466:
1458:
1451:. Retrieved
1424:
1412:
1403:
1396:. Retrieved
1389:
1379:
1347:. Retrieved
1336:
1329:
1317:. Retrieved
1302:
1291:
1234:
1228:
1222:
1169:
1163:
1157:
1145:. Retrieved
1130:
1119:
1087:. Retrieved
1076:
1069:
1057:. Retrieved
1042:
1031:
1019:. Retrieved
1008:
997:
985:. Retrieved
974:
963:
951:. Retrieved
944:
933:
921:. Retrieved
914:
903:
891:. Retrieved
884:
873:
522:– selective
459:JNJ-38893777
347:1.8 blocker
325:Tetrodotoxin
307:1.8 blocker
283:1.7 blocker
271:1.7 blocker
261:1.8 blocker.
144:
129:full agonist
121:Cebranopadol
84:
77:
75:
60:
51:
32:
15:
3385:hydrocodone
3303:desipramine
3265:lamotrigine
3249:mirogabalin
3173:milnacipran
3079:from market
3023:Frunevetmab
3003:Bedinvetmab
2912:PF-05089771
2821:Mirogabalin
2782:Ion channel
2752:Cannabidiol
2705:Benzydamine
2648:Pyrazolones
2630:Wintergreen
2580:Ethenzamide
2575:Dipyrocetyl
2532:Salicylates
2474:Lumiracoxib
2410:Indometacin
2338:Zaltoprofen
2257:Propionates
2167:Acetanilide
2158:Paracetamol
2092:Piritramide
2077:Phenazocine
2072:Phenadoxone
2062:Pentazocine
2057:Oliceridine
2052:Norpipanone
2021:+fluanisone
2002:Dimenoxadol
1982:Carfentanil
1977:Bezitramide
1972:Anileridine
1941:Papaveretum
1936:Oxymorphone
1930:+naltrexone
1892:Nicocodeine
1877:Levorphanol
1846:Hydrocodone
1803:Butorphanol
1748:+naltrexone
1453:14 November
1398:14 November
1367:|work=
1349:14 November
1319:14 November
1304:AdisInsight
1147:14 November
1132:AdisInsight
1107:|work=
1089:14 November
1059:14 November
1044:AdisInsight
1021:14 November
1010:AdisInsight
976:AdisInsight
946:AdisInsight
916:AdisInsight
886:AdisInsight
833:antagonist
813:antagonist
699:(p75-Fc) –
534:Cannabidiol
505:Tivanisiran
422:as well as
359:1.8 blocker
333:Vixotrigine
313:Ralfinamide
297:PF-05089771
167:Lexanopadol
163:antagonist.
155:(NRI), and
3440:Analgesics
3434:Categories
3409:tapentadol
3353:dronabinol
3309:Ziconotide
3281:Mexiletine
3261:lacosamide
3245:pregabalin
3241:gabapentin
3214:tapentadol
3169:duloxetine
3053:Rimazolium
3048:Proglumide
2993:Analgecine
2930:Flupirtine
2873:Mexiletine
2854:Lacosamide
2831:Ziconotide
2826:Pregabalin
2816:Leconotide
2806:Gabapentin
2784:modulators
2767:Nabiximols
2730:Proquazone
2725:Nimesulide
2720:Nabumetone
2671:Nifenazone
2585:Guacetisal
2570:Diflunisal
2555:Benorylate
2489:Valdecoxib
2469:Etoricoxib
2400:Diclofenac
2390:Acemetacin
2359:Lornoxicam
2313:Loxoprofen
2300:Ketoprofen
2269:Fenoprofen
2234:Phenacetin
2212:+oxycodone
2202:+ibuprofen
2134:+celecoxib
2117:Tapentadol
2112:Sufentanil
2087:Piminodine
2037:Meptazinol
2032:Lofentanil
2007:Dipipanone
1962:Alfentanil
1922:+ibuprofen
1887:Nalbuphine
1857:+ibuprofen
1689:Analgesics
987:2 November
953:2 November
923:29 October
893:29 October
866:References
748:Ranevetmab
717:NRD135S-E1
656:Fulranumab
572:Dronabinol
540:modulator
497:SAR-115740
437:modulator
303:1.7 and Na
257:1.7 and Na
227:Cenobamate
115:antagonist
80:analgesics
76:This is a
54:April 2022
46:footnoting
3397:methadone
3393:oxycodone
3375:methadone
3340:Bupropion
3275:lidocaine
3196:dosulepin
3089:Phase III
3077:Withdrawn
3058:Tanezumab
3018:Clonidine
3013:Capsaicin
2867:lidocaine
2715:Glafenine
2676:Phenazone
2620:Salsalate
2550:Aloxiprin
2499:Fenamates
2484:Rofecoxib
2479:Parecoxib
2463:+tramadol
2456:Celecoxib
2438:Zomepirac
2423:Ketorolac
2395:Bromfenac
2374:Tenoxicam
2369:Piroxicam
2364:Meloxicam
2323:Oxaprozin
2279:Ibuprofen
2222:+tramadol
2177:Butacetin
2042:Methadone
1955:Synthetic
1926:+naloxone
1907:Oxycodone
1836:Etorphine
1797:+naloxone
1764:Paregoric
1619:1946-6234
1611:1946-6242
1554:2160-7648
1502:2160-763X
1494:2160-7648
1435:0743-1791
1369:ignored (
1359:cite book
1275:960771045
1259:0028-3878
1251:1526-632X
1230:Neurology
1198:1381-6128
1190:1873-4286
1109:ignored (
1099:cite book
756:Tanezumab
679:GZ-389988
645:Fasinumab
527:inhibitor
481:Parentide
443:DWP-05195
420:modulator
392:Capsaicin
151:agonist,
3405:tramadol
3389:morphine
3367:ketamine
3357:nabilone
3349:cannabis
3218:tramadol
3028:Ketamine
2907:Funapide
2902:DSP-2230
2762:Nabilone
2757:Cannabis
2661:Ampyrone
2433:Tolmetin
2428:Sulindac
2405:Etodolac
2383:Acetates
2354:Isoxicam
2328:Suprofen
2318:Naproxen
2192:+codeine
2127:Tramadol
2122:Tilidine
2102:Propiram
2017:Fentanyl
1997:Dezocine
1946:Thebacon
1918:+aspirin
1861:+aspirin
1759:Laudanum
1744:Morphine
1732:+aspirin
1637:33692134
1570:32666782
1562:29125700
1518:11755963
1510:29125703
1447:Archived
1443:66652431
1343:Archived
1313:Archived
1283:80887455
1267:55043902
1206:28799516
1141:Archived
1083:Archived
1053:Archived
1015:Archived
981:Archived
854:See also
819:HSP-3150
801:agonist
799:receptor
770:of TrkA
730:ONO-4474
681:– TrkA,
670:against
626:Olorinab
610:NEO-1940
594:Nabilone
536:(CBD) –
520:ABX-1431
473:NEO-6860
467:Mavatrep
451:GRC-6211
435:receptor
418:– TRPV1
398:agonist
370:HSK16149
289:NKTR-171
277:GDC-0310
265:GDC-0276
251:Funapide
247:blocker.
239:1.7 and
233:DSP-2230
190:BIIB-095
161:receptor
42:citation
3383:(e.g.,
3381:Opioids
3365:(e.g.,
3347:(e.g.,
3293:(e.g.,
3273:(e.g.,
3239:(e.g.,
3212:(e.g.,
3186:(e.g.,
3167:(e.g.,
3033:Menthol
3008:Camphor
2885:(e.g.,
2878:Nefopam
2863:cocaine
2861:(e.g.,
2610:Salicin
2347:Oxicams
2172:Bucetin
2144:Viminol
1882:Metopon
1727:Codeine
1715:Opiates
1706:Opioids
1628:8830379
1597:(584).
1214:3676340
827:KCP-506
807:E-52862
791:CR-4056
783:ALLOD-2
764:VM-902A
697:LEVI-04
664:GBR-900
556:CMX-020
416:CMX-020
222:blocker
211:CC-8464
173:agonist
3318:Others
3202:Opioid
3072:WHO-EM
2986:Others
2698:Others
2684:
2633:
2459:
2413:
2303:
2290:
2282:
2249:NSAIDs
2130:
1910:
1849:
1821:
1793:
1635:
1625:
1617:
1609:
1568:
1560:
1552:
1516:
1508:
1500:
1492:
1441:
1433:
1281:
1273:
1265:
1257:
1249:
1212:
1204:
1196:
1188:
1172:(37).
1049:Biogen
845:PAX-01
777:Others
736:, and
703:(p75)
685:, and
616:and CB
600:and CB
582:and CB
562:and CB
353:VX-548
341:VX-150
110:, and
3161:SNRIs
2160:-type
2047:NFEPP
1754:Opium
1719:opium
1607:eISSN
1566:S2CID
1514:S2CID
1490:eISSN
1279:S2CID
1247:eISSN
1210:S2CID
1186:eISSN
839:LATER
396:TRPV1
3287:TCAs
3206:MRIs
3180:TCAs
3139:and
1697:N02B
1693:N02A
1633:PMID
1615:ISSN
1558:PMID
1550:ISSN
1506:PMID
1498:ISSN
1455:2022
1439:OCLC
1431:ISSN
1400:2022
1371:help
1351:2022
1321:2022
1271:OCLC
1263:LCCN
1255:ISSN
1202:PMID
1194:ISSN
1149:2022
1111:help
1091:2022
1061:2022
1023:2022
989:2022
955:2022
925:2022
895:2022
738:TrkC
734:TrkB
707:and
687:TrkC
683:TrkB
672:TrkA
612:– CB
596:– CB
429:and
157:5-HT
131:and
106:μ-,
44:and
3417:GHB
1623:PMC
1599:doi
1542:doi
1482:doi
1239:doi
1178:doi
576:THC
574:(Δ-
384:TRP
245:1.8
219:1.7
205:1.7
3436::
3407:,
3403:,
3399:,
3395:,
3391:,
3387:,
3373:,
3369:,
3355:,
3351:,
3301:,
3297:,
3263:,
3259:,
3255:,
3251:,
3247:,
3243:,
3216:,
3194:,
3190:,
3171:,
3085::
2895:Na
2865:,
2136:,
1928:,
1924:,
1920:,
1916:,
1859:,
1855:,
1695:,
1631:.
1621:.
1613:.
1605:.
1595:13
1593:.
1587:.
1564:.
1556:.
1548:.
1536:.
1512:.
1504:.
1496:.
1488:.
1476:.
1457:.
1445:.
1437:.
1429:.
1423:.
1402:.
1388:.
1363::
1361:}}
1357:{{
1307:.
1301:.
1277:.
1269:.
1261:.
1253:.
1245:.
1235:90
1233:.
1208:.
1200:.
1192:.
1184:.
1170:23
1168:.
1135:.
1129:.
1103::
1101:}}
1097:{{
1047:.
1041:.
1007:.
973:.
943:.
913:.
883:.
829:–
793:–
719:–
666:–
431:CB
424:CB
241:Na
215:Na
201:Na
194:Na
159:2C
108:κ-
3419:)
3411:)
3377:)
3359:)
3305:)
3277:)
3267:)
3220:)
3198:)
3175:)
3129:e
3122:t
3115:v
2897:v
2889:)
2869:)
2690:)
2686:(
2639:)
2635:(
2546:)
2542:(
2465:)
2461:(
2419:)
2415:(
2309:)
2305:(
2296:)
2292:(
2288:)
2284:(
2140:)
2132:(
2023:)
2019:(
1932:)
1912:(
1863:)
1851:(
1827:)
1823:(
1799:)
1795:(
1750:)
1746:(
1717:/
1699:)
1691:(
1681:e
1674:t
1667:v
1639:.
1601::
1572:.
1544::
1538:7
1520:.
1484::
1478:7
1373:)
1353:.
1323:.
1285:.
1241::
1216:.
1180::
1151:.
1113:)
1093:.
1063:.
1025:.
991:.
957:.
927:.
897:.
797:2
630:2
618:2
614:1
602:2
598:1
584:2
580:1
564:2
560:1
433:2
426:1
374:2
357:v
345:v
305:v
301:v
281:v
269:v
259:v
255:v
243:v
237:v
217:v
207:.
203:v
196:v
145:O
143:(
117:.
67:)
61:(
56:)
52:(
48:.
38:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.