425:-labeled lipiodol. The radioactive lipiodol is attracted to the tumor, much like regular lipiodol. Its radioactivity destroys tumor tissue. However, I-lipiodol has been withdrawn from the market by its European manufacturer due to risk of embolism, especially in patients with hepatic arterio-venous shunting. I-lipidol is also less tumor-targeted than the microbeads used in conventional TARE procedures, requiring much higher radiation doses. It remains available in India, where its cost-effectiveness over conventional Y TARE is valued.
284:
475:
salt. Beyond poppyseed oil, locally-available rapeseed (Brassiodol), peanut, walnut, and soybean oils have also been used for producing iodized oil for oral use. These iodized oils have different pharmacological profiles, but have also proven successful in eradicating goiter at a lower cost. In fact, iodized rapeseed and peanut oils provide longer-lasting protection from goiter compared to
Lipiodol.
527:
version, Lipiodol Ultra Fluide, was proposed by
Wallace specifically for this purpose in 1960. In 1981, Japanese professor Konno found that when Lipidol is injected into the hepatic artery of patients with hepatocarcinoma, the oily substance is selectively retained by the tumor for several months. He mixed Lipidol with a new drug SMANCS to selectively target cancer cells; thus,
389:(HSG: a procedure to determine tubal patency , used in the investigation of subfertility). It became less commonly utilized in the 1960s to 1980s because the more modern water-soluble media give images that are easier to interpret. There is also an important safety issue with Lipiodol in that intravasation (leakage) of the fluid into the venous system has caused
2090:
526:
by two French physicians, Jacques
Forestier and Jean Sicard in 1921). It was first used for lymphography in 1960 as a replacement for the earlier water-soluble contrasts, which quickly diffused outside the lymphatic network and prevented visualization beyond the first few nodes. A transesterified
474:
Iodized poppyseed oil (Lipiodol) given orally or intermuscularly produces a long-lasting store of iodine in the body, allowing very infrequent dosing. Iodized oil is a cost-effective way of combating iodine deficiency. There seems to be a lower risk of initial hyperthyroidism compared to iodized
349:
Iodized oil was first made in 1901 by Marcel
Guerbet and Laurent Lafay. Originally used to treat iodine deficiency, it was identified as an effective radiocontrast in 1921 by Sicard and Forestier, before returning as a tool to treat iodine deficiency in goiter eradication campaigns of the 1980s.
1269:
Markou KB, Georgopoulos NA, Makri M, Vlasopoulou B, Anastasiou E, Vagenakis GA, et al. (2003). "Improvement of iodine deficiency after iodine supplementation in schoolchildren of
Azerbaijan was accompanied by hypo and hyperthyrotropinemia and increased title of thyroid autoantibodies".
538:
to fight endemic goitre via intramuscular injection. The technique received increasing approval and refinement as a supplement to salt iodization from the Pan
American Health Organisation, UNICEF, and WHO. In 1989, it was added to the WHO Model List of Essential Medications.
1073:
Andreana L, Isgrò G, Marelli L, Davies N, Yu D, Navalkissoor S, et al. (October 2012). "Treatment of hepatocellular carcinoma (HCC) by intra-arterial infusion of radio-emitter compounds: trans-arterial radio-embolisation of HCC".
470:
Lipiodol is given once or twice yearly to remote communities at risk of endemic goitre. The oil can be taken orally or injected intermuscularly. There is also an oral capsule that contains the oil, equivalent to 190 mg iodine.
449:
Since the 2000s, a small number of studies have suggested that flushing lipiodol through the fallopian tubes (similar to what is done in HSG, but without imaging) might provide a short-term rise in fecundity in patients with
1109:
Qian Y, Liu Q, Li P, Han Y, Zhang J, Xu J, et al. (February 2021). "Highly Tumor-Specific and Long-Acting Iodine-131 Microbeads for
Enhanced Treatment of Hepatocellular Carcinoma with Low-Dose Radio-Chemoembolization".
322:
that is used to outline structures in radiological investigations. When given orally or by intramuscular injection once or twice a year, it prevents endemic goitre in remote communities. It has an additional use in
550:
supplied thiodized oil for interventional procedure under the brand name "Ethiodol" to the US market until 2011, when the product was discotinued. The
Ethiodol product is equivalent to Lipiodol Ultra Fluide.
409:
into lipiodol to form a suspension. Guided by an imaging system, a catheter is moved into an artery that feeds the tumor and injects the suspension. Lipiodol helps retain the drug around the cancer cells. An
995:
de Baere T, Arai Y, Lencioni R, Geschwind JF, Rilling W, Salem R, et al. (March 2016). "Treatment of Liver Tumors with
Lipiodol TACE: Technical Recommendations from Experts Opinion".
462:
when using
Lipiodol flushing. A 2020 Cochrane review suggests that flushing with oil-soluble contrast media such as lipiodol may increase the chance of live birth and clinical pregnancy.
342:
referring to the risk of embolism. Use as iodine supplementation is recommended in regions where deficiency is common, otherwise it is not recommended. It should not be used for
123:
1155:"Transarterial Radioembolization (TARE) with Iodine-Lipiodol for Unresectable Primary Hepatocellular Carcinoma: Experience from a Tertiary Care Center in India"
63:
507:
are iodinated. The product is washed and purified to remove any free elemental iodine and other organic compounds, leaving only the iodinated esters.
1535:
1377:
Ingenbleek Y, Jung L, Férard G, Bordet F, Goncalves AM, Dechoux L (November 1997). "Iodised rapeseed oil for eradication of severe endemic goitre".
402:
375:
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1358:
925:
744:
515:
Lipiodol was first synthesized by Marcel Guerbet in the Paris School of Pharmacy in 1901. It was originally used to treat iodine deficiency.
351:
608:
Ahrar K, Gupta S (January 2003). "Hepatic artery embolization for hepatocellular carcinoma: technique, patient selection, and outcomes".
503:
using silylated reagents, then reacting the acid with fatty acid ethyl esters. Sufficient amounts of the acid is used to ensure that all
1860:
499:, primarily as ethyl monoiodostearate and ethyl diiodostearate. One method to produce the oil involves turning iodine into anhydrous
707:
861:"Multidetector-row computed tomography in the management of hepatocellular carcinoma with transcatheter arterial chemoembolization"
418:
164:
81:
763:
1251:
1038:
Ahmadzadehfar H, Sabet A, Wilhelm K, Biersack HJ, Risse J (November 2011). "Iodine-131-lipiodol therapy in hepatic tumours".
2110:
100:
2080:
1993:
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applications as a contrast agent in follow-up imaging. Lipiodol is also used in lymphangiography, the imaging of the
1420:
Untoro J, Schultink W, Gross R, West CE, Hautvast JG (March 1998). "Efficacy of different types of iodised oil".
831:
685:
458:. A 2005 systematic review has suggested a significant increase in fertility, especially in those women who have
421:" (TARE) is a similar procedure where the anticancer drug is radioactive. An experimental version of TARE uses
2049:
1926:
1521:
451:
390:
111:
279:
261:
580:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
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2005:
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1842:
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The use of Lipiodol against iodine deficiency was revived in 1957 by Mac Cullagh, who used it in
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796:[The history of Lipiodol (1901-1994) or How a medication may evolve with the times].
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379:
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Johnson NP (2005). "A review of the use of lipiodol flushing for unexplained infertility".
241:
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324:
205:
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Wang R, Watson A, Johnson N, Cheung K, Fitzgerald C, Mol BW, et al. (October 2020).
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by mouth, injection (IM, intralymphatic, intrauterine, selective hepatic intra-arterial)
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1900:
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1600:
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1350:
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794:"Histoire du Lipiodol (1901-1994) ou Comment un médicament peut évoluer avec son temps"
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When used as tissue contrast, iodized oil has a risk of entering the vein and causing
2104:
2010:
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Gomi T, Hasegawa M (2012). "Radiological contrast agents and radiopharmaceuticals".
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Ethiodized oil for interventional procedure was solely produced and marketed by
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27:
Medication derived from poppyseed oil and iodine often used as a contrast agent
1979:
1959:
1885:
1870:
1796:
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1008:
492:
422:
406:
216:
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Sato T (April 2002). "Locoregional immuno(bio)therapy for liver metastases".
2014:
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67:
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Patel A, Subbanna I, Bhargavi V, Swamy S, Kallur KG, Patil S (April 2021).
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1016:
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836:
World Health Organization model list of essential medicines: 21st list 2019
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405:(TACE), a procedure for treating liver tumors. An anticancer drug is first
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411:
912:. Recent Results in Cancer Research. Vol. 157. pp. 109–20.
484:
308:
252:
1302:"Physiology and pharmacology of iodized oil in goiter prophylaxis"
1341:
Medeiros-Neto G, Rubio IG (2016). "Iodine-Deficiency Disorders".
414:
material is then injected to restrict blood supply to the tumor.
1517:
173:
90:
587:
908:
Cabanas RM (2000). "The Concept of the Sentinel Lymph Node".
454:. This procedure is called Lipiodol flushing or more broadly
385:
Historically Lipiodol was often used as a contrast medium at
562:
launched its oil under the brand name "Vividol" in 2022.
848:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
352:
World Health Organization's List of Essential Medicines
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as a dilutant that does not affect polymerization of
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as a dilutant that does not affect polymerization of
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ethiodized oil, ethyl esters of iodised fatty acids
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44:
39:
910:Lymphatic Metastasis and Sentinel Lymphonodectomy
1465:Journal of Vascular and Interventional Radiology
1463:Kolbeck KJ (March 2011). "Lipiodol = ethiodol".
1295:
1293:
947:
945:
764:"DailyMed - LIPIODOL- ethiodized oil injection"
688:(2009). Stuart MC, Kouimtzi M, Hill SR (eds.).
350:Under the name "iodine", iodized oil is on the
204:
1529:
1372:
1370:
8:
99:
32:
1252:"IODIZED OIL oral | MSF Medical Guidelines"
1208:The Cochrane Database of Systematic Reviews
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865:Journal of Gastroenterology and Hepatology
692:. World Health Organization. p. 499.
610:Surgical Oncology Clinics of North America
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1272:Journal of Endocrinological Investigation
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403:transcatheter arterial chemoembolization
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838:. Geneva: World Health Organization.
518:Historically, Lipiodol was the first
260:
72:
7:
1509:. U.S. National Library of Medicine.
146:
135:
338:in the brain and lungs. There is a
1351:10.1016/B978-0-323-18907-1.00091-3
1343:Endocrinology: Adult and Pediatric
859:Guan YS, Hu Y, Liu Y (June 2006).
737:10.1016/b978-0-444-59499-0.00046-5
25:
1204:"Tubal flushing for subfertility"
401:Lipiodol is used in conventional
2088:
1319:10.1097/00005792-200101000-00003
966:10.2165/00024677-200504040-00004
878:10.1111/j.1440-1746.2006.04474.x
798:Revue d'Histoire de la Pharmacie
792:Bonnemain B, Guerbet M (1995).
419:Transarterial radioembolization
303:, is a medication derived from
1220:10.1002/14651858.CD003718.pub5
483:Ethiodized oil is composed of
354:, in liquid and capsule form.
1:
1434:10.1016/S0140-6736(05)78525-1
1391:10.1016/s0140-6736(97)02427-6
1159:South Asian Journal of Cancer
622:10.1016/s1055-3207(02)00089-3
435:gastric variceal obliteration
429:Gastric variceal obliteration
325:gastric variceal obliteration
725:Side Effects of Drugs Annual
433:It has an additional use in
1052:10.1016/j.ymeth.2011.05.003
954:Treatments in Endocrinology
918:10.1007/978-3-642-57151-0_9
50:Lipiodol, Ethiodol, Vividol
2127:
1477:10.1016/j.jvir.2010.10.030
1088:10.1016/j.ctrv.2011.11.004
2039:
1256:medicalguidelines.msf.org
1009:10.1007/s00270-015-1208-y
832:World Health Organization
686:World Health Organization
1300:Wolff J (January 2001).
1076:Cancer Treatment Reviews
690:WHO Model Formulary 2008
520:iodinated contrast agent
74:International Drug Names
1927:Ferric ammonium citrate
1507:Drug Information Portal
1124:10.1021/acsnano.0c09122
810:10.3406/pharm.1995.4238
657:10.1053/sonc.2002.31716
452:unexplained infertility
445:Fallopian tube flushing
1171:10.1055/s-0041-1731600
387:hysterosalpingography
344:hysterosalpingography
2111:Radiocontrast agents
768:dailymed.nlm.nih.gov
645:Seminars in Oncology
2031:Sulfur hexafluoride
1385:(9090): 1542–1545.
548:Savage Laboratories
151:): goiter treatment
36:
2066:Never to phase III
1278:(2 Suppl): 43–48.
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1942:Superparamagnetic
1891:Gadopentetic acid
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1428:(9104): 752–753.
1360:978-0-323-18907-1
927:978-3-642-63070-5
746:978-0-444-59499-0
529:chemoembolization
466:Iodine deficiency
397:Chemoembolization
376:chemoembolization
367:Iodized oil is a
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16:(Redirected from
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1606:Ioxitalamic acid
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380:lymphatic system
374:. It is used in
311:. When given by
295:, also known as
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1911:Gadoversetamide
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1782:Water insoluble
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1757:Sodium iopodate
1742:Iobenzamic acid
1732:Ioglycamic acid
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2086:
2082:
2065:
2063:
2060:
2059:
2057:
2054:
2051:
2048:
2046:
2043:
2042:
2038:
2032:
2029:
2027:
2026:phospholipids
2023:
2021:
2018:
2016:
2012:
2009:
2007:
2006:human albumin
2003:
2000:
1999:
1997:
1995:
1991:
1981:
1978:
1977:
1975:
1971:
1965:
1964:nanoparticles
1961:
1958:
1956:
1953:
1951:
1948:
1947:
1945:
1943:
1939:
1933:
1930:
1928:
1924:
1921:
1920:
1917:
1914:
1912:
1909:
1907:
1904:
1902:
1899:
1897:
1894:
1892:
1889:
1887:
1884:
1882:
1879:
1877:
1874:
1872:
1869:
1867:
1863:
1862:
1858:
1857:
1855:
1853:
1849:
1846:
1844:
1840:
1830:
1827:
1826:
1824:
1822:Non-iodinated
1820:
1814:
1811:
1809:
1806:
1804:
1801:
1798:
1794:
1790:
1787:
1786:
1784:
1778:
1768:
1765:
1763:
1760:
1758:
1755:
1753:
1750:
1748:
1747:Iopanoic acid
1745:
1743:
1740:
1738:
1735:
1733:
1730:
1728:
1727:Iotroxic acid
1725:
1723:
1720:
1719:
1717:
1713:
1707:
1704:
1702:
1699:
1697:
1694:
1692:
1689:
1687:
1684:
1682:
1679:
1677:
1674:
1672:
1669:
1667:
1664:
1662:
1661:Ioxaglic acid
1659:
1657:
1654:
1652:
1649:
1648:
1646:
1644:
1640:Nephrotropic,
1638:
1632:
1629:
1627:
1624:
1622:
1621:Iocarmic acid
1619:
1617:
1614:
1612:
1611:Ioglicic acid
1609:
1607:
1604:
1602:
1599:
1597:
1594:
1592:
1589:
1587:
1584:
1583:
1581:
1579:
1575:Nephrotropic,
1573:
1570:
1568:Water soluble
1564:
1561:
1559:
1555:
1550:
1546:
1539:
1534:
1532:
1527:
1525:
1520:
1519:
1516:
1508:
1504:
1500:
1499:
1495:
1486:
1482:
1478:
1474:
1470:
1466:
1459:
1456:
1451:
1447:
1443:
1439:
1435:
1431:
1427:
1423:
1416:
1413:
1408:
1404:
1400:
1396:
1392:
1388:
1384:
1380:
1373:
1371:
1367:
1362:
1356:
1352:
1348:
1344:
1337:
1334:
1329:
1325:
1320:
1315:
1311:
1307:
1303:
1296:
1294:
1290:
1285:
1281:
1277:
1273:
1265:
1262:
1257:
1253:
1247:
1244:
1239:
1235:
1230:
1225:
1221:
1217:
1213:
1209:
1205:
1198:
1195:
1190:
1186:
1181:
1176:
1172:
1168:
1164:
1160:
1156:
1149:
1146:
1141:
1137:
1133:
1129:
1125:
1121:
1117:
1113:
1105:
1102:
1097:
1093:
1089:
1085:
1081:
1077:
1069:
1066:
1061:
1057:
1053:
1049:
1045:
1041:
1034:
1031:
1026:
1022:
1018:
1014:
1010:
1006:
1002:
998:
991:
988:
983:
979:
975:
971:
967:
963:
959:
955:
948:
946:
942:
937:
933:
929:
923:
919:
915:
911:
904:
901:
896:
892:
888:
884:
879:
874:
870:
866:
862:
855:
852:
846:
841:
837:
833:
827:
824:
819:
815:
811:
807:
803:
800:(in French).
799:
795:
788:
786:
784:
782:
780:
778:
774:
769:
765:
759:
757:
753:
748:
742:
738:
734:
730:
726:
719:
716:
711:
709:9789241547659
705:
700:
695:
691:
687:
681:
679:
677:
675:
671:
666:
662:
658:
654:
650:
646:
639:
636:
631:
627:
623:
619:
615:
611:
604:
601:
589:
585:
581:
575:
572:
565:
563:
561:
557:
552:
549:
543:Supply status
542:
540:
537:
532:
530:
525:
521:
516:
510:
508:
506:
502:
498:
497:poppyseed oil
494:
490:
487:reacted with
486:
478:
476:
472:
465:
463:
461:
460:endometriosis
457:
453:
444:
442:
440:
439:cyanoacrylate
436:
428:
426:
424:
420:
415:
413:
408:
404:
396:
394:
393:in the past.
392:
391:complications
388:
383:
381:
377:
373:
370:
362:
357:
355:
353:
347:
345:
341:
340:boxed warning
337:
332:
330:
329:cyanoacrylate
326:
321:
318:
314:
310:
306:
305:poppyseed oil
302:
299:, brand name
298:
294:
285:
281:
278:
276:
274:ECHA InfoCard
270:
263:
262:ChEMBL1201458
259:
258:
256:
254:
250:
243:
239:
238:
236:
234:
230:
223:
222:
220:
218:
214:
207:
203:
202:
200:
198:
194:
189:
183:
171:
170:
168:
166:
162:
157:
149:
144:
138:
133:
130:
129:
127:
125:
121:
117:
115:
109:
102:
97:
88:
87:
85:
83:
79:
75:
71:
69:
65:
61:
57:
53:
49:
47:
43:
40:Clinical data
38:
30:
19:
2020:Perflenapent
2002:Microspheres
1932:Mangafodipir
1922:
1896:Gadopiclenol
1881:Gadofosveset
1859:
1852:Paramagnetic
1808:Propyliodone
1793:Ethyl esters
1715:Hepatotropic
1578:high osmolar
1558:X-ray and CT
1506:
1468:
1464:
1458:
1425:
1421:
1415:
1382:
1378:
1342:
1336:
1312:(1): 20–36.
1309:
1305:
1275:
1271:
1264:
1255:
1246:
1211:
1207:
1197:
1165:(2): 81–86.
1162:
1158:
1148:
1115:
1111:
1104:
1079:
1075:
1068:
1043:
1039:
1033:
1000:
996:
990:
957:
953:
909:
903:
868:
864:
854:
845:10665/325771
835:
826:
801:
797:
767:
728:
724:
718:
689:
648:
644:
638:
613:
609:
603:
591:. Retrieved
583:
574:
553:
546:
533:
517:
514:
505:double bonds
489:ethyl esters
482:
473:
469:
448:
432:
416:
400:
384:
369:radio-opaque
366:
358:Medical uses
348:
333:
317:radio-opaque
300:
296:
292:
291:
165:Legal status
159:Legal status
82:License data
29:
2052:from market
1906:Gadoteridol
1876:Gadodiamide
1813:Iofendylate
1799:, lipiodol)
1797:fatty acids
1795:of iodised
1651:Metrizamide
1643:low osmolar
731:: 749–760.
699:10665/44053
524:myelography
493:fatty acids
293:Iodized oil
280:100.122.502
191:Identifiers
55:Other names
46:Trade names
34:Iodized oil
1994:Ultrasound
1980:Perflubron
1960:Iron oxide
1955:Ferristene
1950:Ferumoxsil
1886:Gadolinium
1871:Gadobutrol
1780:Iodinated,
1737:Adipiodone
1701:Iobitridol
1566:Iodinated,
566:References
531:was born.
522:(used for
423:iodine-131
407:emulsified
315:, it is a
242:KZW0R0686Q
217:ChemSpider
197:CAS Number
2062:Phase III
2050:Withdrawn
2015:galactose
1691:Iodixanol
1671:Iopromide
1666:Iopamidol
1626:Methiodal
1140:231788293
479:Chemistry
313:injection
206:8008-53-5
112:Routes of
68:Drugs.com
2105:Category
2095:Medicine
1696:Iomeprol
1686:Iopentol
1681:Ioversol
1676:Iotrolan
1596:Iodamide
1485:21277801
1450:45475444
1328:11204500
1306:Medicine
1284:12762640
1238:33053612
1189:34568220
1132:33529007
1112:ACS Nano
1096:22169503
1060:21664971
1025:12719852
1017:26390875
982:25322807
974:16053340
936:10857165
895:40066693
887:16724976
834:(2019).
818:11640460
665:11951214
630:12735133
558:, until
336:embolism
301:Lipiodol
124:ATC code
96:DailyMed
18:Lipiodol
1803:Iopydol
1706:Ioxilan
1656:Iohexol
1631:Diodone
1442:9504541
1399:9388412
1229:9508794
1180:8460342
1040:Methods
556:Guerbet
511:History
412:embolic
363:Imaging
181:WARNING
145: (
134: (
132:V08AD01
98::
2081:Portal
2045:WHO-EM
1483:
1448:
1440:
1422:Lancet
1405:
1397:
1379:Lancet
1357:
1326:
1282:
1236:
1226:
1187:
1177:
1138:
1130:
1094:
1058:
1023:
1015:
980:
972:
934:
924:
893:
885:
816:
743:
706:
663:
628:
593:22 Oct
485:iodine
309:iodine
253:ChEMBL
178:
94:
1973:Other
1923:Other
1446:S2CID
1407:93815
1403:S2CID
1136:S2CID
1021:S2CID
978:S2CID
891:S2CID
143:H03CA
1481:PMID
1438:PMID
1395:PMID
1355:ISBN
1324:PMID
1280:PMID
1234:PMID
1212:2020
1185:PMID
1128:PMID
1092:PMID
1056:PMID
1013:PMID
970:PMID
932:PMID
922:ISBN
883:PMID
814:PMID
741:ISBN
704:ISBN
661:PMID
626:PMID
595:2023
307:and
233:UNII
224:none
64:AHFS
2013:of
2004:of
1843:MRI
1791:(=
1549:V08
1473:doi
1430:doi
1426:351
1387:doi
1383:350
1347:doi
1314:doi
1224:PMC
1216:doi
1175:PMC
1167:doi
1120:doi
1084:doi
1048:doi
1005:doi
962:doi
914:doi
873:doi
840:hdl
806:doi
733:doi
694:hdl
653:doi
618:doi
588:FDA
495:of
491:of
148:WHO
137:WHO
2107::
2058::
1962:,
1925::
1864::
1505:.
1479:.
1469:22
1467:.
1444:.
1436:.
1424:.
1401:.
1393:.
1381:.
1369:^
1353:.
1322:.
1310:80
1308:.
1304:.
1292:^
1276:26
1274:.
1254:.
1232:.
1222:.
1210:.
1206:.
1183:.
1173:.
1163:10
1161:.
1157:.
1134:.
1126:.
1116:15
1114:.
1090:.
1080:38
1078:.
1054:.
1044:55
1042:.
1019:.
1011:.
1001:39
999:.
976:.
968:.
956:.
944:^
930:.
920:.
889:.
881:.
869:21
867:.
863:.
812:.
802:42
776:^
766:.
755:^
739:.
729:34
727:.
702:.
673:^
659:.
649:29
647:.
624:.
614:12
612:.
586:.
582:.
441:.
382:.
331:.
174:US
91:US
2083::
1551:)
1547:(
1537:e
1530:t
1523:v
1487:.
1475::
1452:.
1432::
1409:.
1389::
1363:.
1349::
1330:.
1316::
1286:.
1258:.
1240:.
1218::
1191:.
1169::
1142:.
1122::
1098:.
1086::
1062:.
1050::
1027:.
1007::
984:.
964::
958:4
938:.
916::
897:.
875::
842::
820:.
808::
770:.
749:.
735::
712:.
696::
667:.
655::
632:.
620::
597:.
417:"
176::
66:/
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
