Knowledge

Logrank test

Source 📝

4928: 2403: 4914: 4952: 4940: 2390:
survival curve—namely, that censoring is unrelated to prognosis, the survival probabilities are the same for subjects recruited early and late in the study, and the events happened at the times specified. Deviations from these assumptions matter most if they are satisfied differently in the groups
1234: 87:
of the two groups at each observed event time. It is constructed by computing the observed and expected number of events in one of the groups at each observed event time and then adding these to obtain an overall summary across all-time points where there is an event.
920: 1737: 47:
to establish the efficacy of a new treatment in comparison with a control treatment when the measurement is the time to event (such as the time from initial treatment to a heart attack). The test is sometimes called the
2229:
The logrank statistic is asymptotically equivalent to the likelihood ratio test statistic for any family of distributions with proportional hazard alternative. For example, if the data from the two samples have
1062: 2361: 2156: 2102: 1357:. An improved approximation can be obtained by equating this quantity to Pearson type I or II (beta) distributions with matching first four moments, as described in Appendix B of the Peto and Peto paper. 1599: 760: 2199: 1548:
is the expected number of events at the time of the analysis), and the proportion of subjects randomized to each group is 50%, then the logrank statistic is approximately normal with mean
765: 501: 423: 358: 2304: 1416: 1994: 961: 1764: 1443: 121: 1791: 1900: 1645: 1483: 1619: 1463: 1383: 1027: 994: 657: 593: 273: 240: 187: 154: 2048: 2021: 1954: 1927: 1880: 1853: 1826: 1315: 1054: 684: 624: 560: 528: 4049: 1260: 1546: 4554: 2275: 2255: 1523: 1503: 1355: 1335: 1280: 293: 207: 2201:. Calculations involving the joint distribution are needed to correctly maintain the error rate when the data are examined multiple times within a study by a 4704: 4328: 53: 2969: 1650: 4102: 4541: 4983: 2964: 2664: 1229:{\displaystyle Z_{i}={\frac {\sum _{j=1}^{J}(O_{i,j}-E_{i,j})}{\sqrt {\sum _{j=1}^{J}V_{i,j}}}}\ {\xrightarrow {d}}\ {\mathcal {N}}(0,1)} 3568: 2716: 4351: 4243: 2309: 2107: 2053: 1551: 4956: 4529: 4403: 2363:. This relationship is useful when two of the quantities are known (e.g. from a published article), but the third one is needed. 2366:
The logrank statistic can be used when observations are censored. If censored observations are not present in the data then the
4587: 4248: 3993: 3364: 2954: 3578: 1365:
If the two groups have the same survival function, the logrank statistic is approximately standard normal. A one-sided level
4638: 3850: 3657: 3546: 3504: 2539: 2743: 689: 4881: 3840: 3890: 4432: 4381: 4366: 4356: 4225: 4097: 4064: 3845: 3675: 4501: 3802: 4776: 4577: 3556: 3225: 2689: 2219: 596: 4661: 4628: 2416: 2387: 915:{\displaystyle V_{i,j}=E_{i,j}\left({\frac {N_{j}-O_{j}}{N_{j}}}\right)\left({\frac {N_{j}-N_{i,j}}{N_{j}-1}}\right)} 2373:
The logrank statistic gives all calculations the same weight, regardless of the time at which an event occurs. The
2161: 4978: 4633: 4376: 4135: 4041: 4021: 3929: 3640: 3458: 2941: 2813: 1337:
approaches infinity and therefore can be approximated by the standard normal distribution for a sufficiently large
3807: 3573: 3431: 4393: 4161: 3882: 3736: 3665: 3585: 3443: 3424: 3132: 2853: 2202: 4506: 4876: 4643: 4191: 4156: 4120: 3905: 3347: 3256: 3215: 3127: 2818: 2657: 2555:
Schoenfeld, D (1981). "The asymptotic properties of nonparametric tests for comparing survival distributions".
2231: 3913: 3897: 435: 4785: 4398: 4338: 4275: 3635: 3497: 3487: 3337: 3251: 189:
be the number of subjects "at risk" (who have not yet had an event or been censored) at the start of period
4546: 4483: 363: 298: 4823: 4753: 4238: 4125: 3122: 3019: 2926: 2805: 2704: 2367: 40: 4944: 3822: 4848: 4790: 4733: 4559: 4452: 4361: 4087: 3971: 3830: 3712: 3704: 3519: 3415: 3393: 3352: 3317: 3284: 3230: 3205: 3160: 3099: 3059: 2861: 2684: 2223: 1287: 4927: 3817: 2402: 2374: 2280: 2444:(1966). "Evaluation of survival data and two new rank order statistics arising in its consideration". 1388: 4771: 4346: 4295: 4271: 4233: 4151: 4130: 4082: 3961: 3939: 3908: 3694: 3645: 3563: 3536: 3492: 3448: 3210: 2986: 2866: 1959: 4918: 4843: 4766: 4447: 4211: 4204: 4166: 4074: 4054: 4026: 3759: 3625: 3620: 3610: 3602: 3420: 3381: 3271: 3261: 3170: 2949: 2905: 2823: 2748: 2650: 1882:
earlier). Again, assume the hazard functions in the two groups are proportional with hazard ratio
928: 4493: 4932: 4743: 4597: 4442: 4318: 4215: 4199: 4176: 3953: 3687: 3670: 3630: 3541: 3436: 3398: 3369: 3329: 3289: 3235: 3152: 2838: 2833: 2572: 2504: 2408: 1742: 1421: 94: 1769: 4838: 4808: 4800: 4620: 4611: 4536: 4467: 4323: 4308: 4283: 4171: 4112: 3978: 3966: 3592: 3509: 3453: 3376: 3220: 3142: 2921: 2795: 2628: 2535: 2453: 1885: 1624: 1468: 32: 1604: 1448: 1368: 999: 966: 629: 565: 245: 212: 159: 126: 4863: 4818: 4582: 4569: 4462: 4437: 4371: 4303: 4181: 3789: 3682: 3615: 3528: 3475: 3294: 3165: 2959: 2758: 2725: 2618: 2610: 2564: 2527: 2494: 2486: 2377:
statistic gives more weight to earlier events when there are a large number of observations.
2026: 1999: 1932: 1905: 1858: 1831: 1804: 1293: 1032: 662: 602: 533: 506: 4780: 4524: 4386: 4313: 3988: 3862: 3835: 3812: 3781: 3408: 3403: 3357: 3087: 2738: 429: 44: 28: 1239: 1528: 4729: 4724: 3187: 3117: 2763: 2260: 2240: 1508: 1488: 1340: 1320: 1265: 278: 192: 2623: 2598: 4972: 4886: 4853: 4716: 4677: 4488: 4457: 3921: 3875: 3480: 3182: 3009: 2773: 2768: 2441: 1956:
are the probabilities that a subject will have an event at the two time points where
60: 36: 3039: 1525:
is the probability a subject in either group will eventually have an event (so that
4828: 4761: 4738: 4653: 3983: 3279: 3177: 3112: 3054: 2976: 2931: 2590: 2474: 2421: 2391:
being compared, for example if censoring is more likely in one group than another.
84: 68: 2477:; Peto, Julian (1972). "Asymptotically Efficient Rank Invariant Test Procedures". 1732:{\displaystyle n={\frac {4\,(z_{\alpha }+z_{\beta })^{2}}{d\log ^{2}{\lambda }}}} 4871: 4833: 4516: 4417: 4279: 4092: 4059: 3551: 3468: 3463: 3107: 3064: 3044: 3024: 3014: 2783: 2594: 2531: 72: 3717: 3197: 2897: 2828: 2778: 2753: 2673: 2614: 2568: 2499: 2398: 2215: 3870: 3722: 3342: 3137: 3049: 3034: 3029: 2994: 43:(technically, the censoring must be non-informative). It is widely used in 2632: 1855:
are the logrank statistics at two different time points in the same study (
2457: 3386: 3004: 2881: 2876: 2871: 2843: 4891: 4592: 2576: 2508: 2222:
comparing two groups. It is therefore asymptotically equivalent to the
1465:
quantile of the standard normal distribution. If the hazard ratio is
4813: 3794: 3768: 3748: 2999: 2790: 2522:
Harrington, David (2005). "Linear Rank Tests in Survival Analysis".
2490: 1194: 16:
Hypothesis test to compare the survival distributions of two samples
91:
Consider two groups of patients, e.g., treatment vs. control. Let
2733: 4702: 4269: 4016: 3315: 3085: 2702: 2646: 39:
test and appropriate to use when the data are right skewed and
2356:{\displaystyle \log {\hat {\lambda }}\approx Z\,{\sqrt {4/D}}} 2151:{\displaystyle \log {\lambda }\,{\sqrt {\frac {n\,d_{2}}{4}}}} 2097:{\displaystyle \log {\lambda }\,{\sqrt {\frac {n\,d_{1}}{4}}}} 123:
be the distinct times of observed events in either group. Let
2642: 1594:{\displaystyle (\log {\lambda })\,{\sqrt {\frac {n\,d}{4}}}} 1206: 52:. The logrank test can also be viewed as a time-stratified 2386:
The logrank test is based on the same assumptions as the
432:
is that the two groups have identical hazard functions,
1793:
are the quantiles of the standard normal distribution.
1317:
converges to that of a standard normal distribution as
275:
be the observed number of events in the groups at time
2312: 2283: 2263: 2243: 2164: 2110: 2056: 2029: 2002: 1962: 1935: 1908: 1888: 1861: 1834: 1807: 1772: 1745: 1653: 1627: 1607: 1554: 1531: 1511: 1491: 1471: 1451: 1424: 1391: 1371: 1343: 1323: 1296: 1268: 1242: 1065: 1035: 1002: 969: 931: 768: 755:{\displaystyle E_{i,j}=O_{j}{\frac {N_{i,j}}{N_{j}}}} 692: 665: 632: 605: 568: 536: 509: 438: 366: 301: 281: 248: 215: 195: 162: 129: 97: 83:
The logrank test statistic compares estimates of the
4555:
Autoregressive conditional heteroskedasticity (ARCH)
4862: 4799: 4752: 4715: 4670: 4652: 4619: 4610: 4568: 4515: 4476: 4425: 4416: 4337: 4294: 4224: 4190: 4144: 4111: 4073: 4040: 3952: 3861: 3780: 3735: 3703: 3656: 3601: 3527: 3518: 3328: 3270: 3244: 3196: 3151: 3098: 2985: 2940: 2914: 2896: 2852: 2804: 2724: 2715: 2479:Journal of the Royal Statistical Society, Series A 2355: 2298: 2269: 2249: 2193: 2150: 2096: 2042: 2015: 1988: 1948: 1921: 1894: 1874: 1847: 1820: 1785: 1758: 1731: 1639: 1613: 1593: 1540: 1517: 1497: 1477: 1457: 1437: 1410: 1377: 1349: 1329: 1309: 1274: 1254: 1228: 1048: 1021: 988: 955: 914: 754: 678: 651: 618: 587: 554: 522: 495: 417: 352: 287: 267: 234: 201: 181: 148: 115: 4103:Multivariate adaptive regression splines (MARS) 2194:{\displaystyle {\sqrt {\frac {d_{1}}{d_{2}}}}} 2050:are approximately bivariate normal with means 2658: 8: 2214:The logrank statistic can be derived as the 4712: 4699: 4616: 4422: 4291: 4266: 4037: 4013: 3741: 3524: 3325: 3312: 3095: 3082: 2721: 2712: 2699: 2665: 2651: 2643: 2469: 2467: 2306:is the estimate of the hazard ratio, then 2622: 2498: 2343: 2338: 2337: 2320: 2319: 2311: 2285: 2284: 2282: 2262: 2242: 2182: 2172: 2165: 2163: 2135: 2130: 2123: 2122: 2117: 2109: 2081: 2076: 2069: 2068: 2063: 2055: 2034: 2028: 2007: 2001: 1980: 1967: 1961: 1940: 1934: 1913: 1907: 1887: 1866: 1860: 1839: 1833: 1812: 1806: 1777: 1771: 1750: 1744: 1721: 1712: 1697: 1687: 1674: 1666: 1660: 1652: 1626: 1606: 1580: 1573: 1572: 1564: 1553: 1530: 1510: 1490: 1470: 1450: 1429: 1423: 1402: 1390: 1370: 1342: 1322: 1301: 1295: 1267: 1241: 1205: 1204: 1189: 1171: 1161: 1150: 1129: 1110: 1097: 1086: 1079: 1070: 1064: 1040: 1034: 1007: 1001: 974: 968: 930: 893: 875: 862: 855: 839: 828: 815: 808: 792: 773: 767: 744: 728: 722: 716: 697: 691: 670: 664: 637: 631: 610: 604: 573: 567: 535: 514: 508: 478: 456: 443: 437: 403: 384: 371: 365: 338: 319: 306: 300: 280: 253: 247: 220: 214: 194: 167: 161: 134: 128: 96: 1385:test will reject the null hypothesis if 2433: 1601:and variance 1. For a one-sided level 686:. This distribution has expected value 496:{\displaystyle H_{0}:h_{1}(t)=h_{2}(t)} 35:distributions of two samples. It is a 4629:Kaplan–Meier estimator (product limit) 2277:is the number of events observed, and 418:{\displaystyle O_{j}=O_{1,j}+O_{2,j}} 353:{\displaystyle N_{j}=N_{1,j}+N_{2,j}} 7: 4939: 4639:Accelerated failure time (AFT) model 2485:(2). Blackwell Publishing: 185–207. 4951: 4234:Analysis of variance (ANOVA, anova) 4329:Cochran–Mantel–Haenszel statistics 2955:Pearson product-moment correlation 14: 2299:{\displaystyle {\hat {\lambda }}} 963:, the logrank statistic compares 209:in the groups, respectively. Let 4950: 4938: 4926: 4913: 4912: 2401: 2226:statistic based from that model. 2209:Relationship to other statistics 1411:{\displaystyle Z>z_{\alpha }} 4588:Least-squares spectral analysis 1989:{\displaystyle d_{1}\leq d_{2}} 59:The test was first proposed by 3569:Mean-unbiased minimum-variance 2325: 2290: 2220:Cox proportional hazards model 1694: 1667: 1647:, the sample size required is 1569: 1555: 1236:     (for 1223: 1211: 1141: 1103: 490: 484: 468: 462: 1: 4984:Time series statistical tests 4882:Geographic information system 4098:Simultaneous equations models 2524:Encyclopedia of Biostatistics 956:{\displaystyle j=1,\ldots ,J} 4065:Coefficient of determination 3676:Uniformly most powerful test 54:Cochran–Mantel–Haenszel test 4634:Proportional hazards models 4578:Spectral density estimation 4560:Vector autoregression (VAR) 3994:Maximum posterior estimator 3226:Randomized controlled trial 2532:10.1002/0470011815.b2a11047 2446:Cancer Chemotherapy Reports 1759:{\displaystyle z_{\alpha }} 1438:{\displaystyle z_{\alpha }} 1290:, the distribution of each 597:hypergeometric distribution 116:{\displaystyle 1,\ldots ,J} 5000: 4394:Multivariate distributions 2814:Average absolute deviation 2257:is the logrank statistic, 1786:{\displaystyle z_{\beta }} 4908: 4711: 4698: 4382:Structural equation model 4290: 4265: 4036: 4012: 3744: 3718:Score/Lagrange multiplier 3324: 3311: 3133:Sample size determination 3094: 3081: 2711: 2698: 2680: 2615:10.1136/bmj.328.7447.1073 2232:exponential distributions 2203:Data Monitoring Committee 4877:Environmental statistics 4399:Elliptical distributions 4192:Generalized linear model 4121:Simple linear regression 3891:Hodges–Lehmann estimator 3348:Probability distribution 3257:Stochastic approximation 2819:Coefficient of variation 1895:{\displaystyle \lambda } 1640:{\displaystyle 1-\beta } 1478:{\displaystyle \lambda } 4537:Cross-correlation (XCF) 4145:Non-standard predictors 3579:Lehmann–ScheffĂ© theorem 3252:Adaptive clinical trial 2569:10.1093/biomet/68.1.316 1614:{\displaystyle \alpha } 1458:{\displaystyle \alpha } 1378:{\displaystyle \alpha } 1361:Asymptotic distribution 1022:{\displaystyle E_{i,j}} 989:{\displaystyle O_{i,j}} 652:{\displaystyle N_{i,j}} 588:{\displaystyle O_{i,j}} 268:{\displaystyle O_{2,j}} 235:{\displaystyle O_{1,j}} 182:{\displaystyle N_{2,j}} 149:{\displaystyle N_{1,j}} 4933:Mathematics portal 4754:Engineering statistics 4662:Nelson–Aalen estimator 4239:Analysis of covariance 4126:Ordinary least squares 4050:Pearson product-moment 3454:Statistical functional 3365:Empirical distribution 3198:Controlled experiments 2927:Frequency distribution 2705:Descriptive statistics 2526:. Wiley Interscience. 2417:Kaplan–Meier estimator 2368:Wilcoxon rank sum test 2357: 2300: 2271: 2251: 2195: 2152: 2098: 2044: 2017: 1990: 1950: 1923: 1896: 1876: 1849: 1822: 1787: 1760: 1733: 1641: 1615: 1595: 1542: 1519: 1499: 1479: 1459: 1439: 1412: 1379: 1351: 1331: 1311: 1276: 1256: 1230: 1166: 1102: 1050: 1023: 990: 957: 916: 756: 680: 653: 620: 589: 556: 524: 497: 419: 354: 289: 269: 236: 203: 183: 150: 117: 4849:Population statistics 4791:System identification 4525:Autocorrelation (ACF) 4453:Exponential smoothing 4367:Discriminant analysis 4362:Canonical correlation 4226:Partition of variance 4088:Regression validation 3932:(Jonckheere–Terpstra) 3831:Likelihood-ratio test 3520:Frequentist inference 3432:Location–scale family 3353:Sampling distribution 3318:Statistical inference 3285:Cross-sectional study 3272:Observational studies 3231:Randomized experiment 3060:Stem-and-leaf display 2862:Central limit theorem 2358: 2301: 2272: 2252: 2224:likelihood ratio test 2196: 2153: 2099: 2045: 2043:{\displaystyle Z_{2}} 2018: 2016:{\displaystyle Z_{1}} 1991: 1951: 1949:{\displaystyle d_{2}} 1924: 1922:{\displaystyle d_{1}} 1897: 1877: 1875:{\displaystyle Z_{1}} 1850: 1848:{\displaystyle Z_{2}} 1823: 1821:{\displaystyle Z_{1}} 1788: 1761: 1734: 1642: 1616: 1596: 1543: 1520: 1500: 1480: 1460: 1440: 1413: 1380: 1352: 1332: 1312: 1310:{\displaystyle Z_{i}} 1288:central limit theorem 1277: 1257: 1231: 1146: 1082: 1051: 1049:{\displaystyle H_{0}} 1024: 991: 958: 917: 757: 681: 679:{\displaystyle O_{j}} 654: 621: 619:{\displaystyle N_{j}} 590: 557: 555:{\displaystyle i=1,2} 525: 523:{\displaystyle H_{0}} 498: 420: 355: 290: 270: 237: 204: 184: 151: 118: 4772:Probabilistic design 4357:Principal components 4200:Exponential families 4152:Nonlinear regression 4131:General linear model 4093:Mixed effects models 4083:Errors and residuals 4060:Confounding variable 3962:Bayesian probability 3940:Van der Waerden test 3930:Ordered alternative 3695:Multiple comparisons 3574:Rao–Blackwellization 3537:Estimating equations 3493:Statistical distance 3211:Factorial experiment 2744:Arithmetic-Geometric 2310: 2281: 2261: 2241: 2162: 2108: 2054: 2027: 2000: 1960: 1933: 1906: 1886: 1859: 1832: 1805: 1770: 1743: 1651: 1625: 1605: 1552: 1529: 1509: 1489: 1469: 1449: 1422: 1389: 1369: 1341: 1321: 1294: 1266: 1240: 1063: 1033: 1000: 967: 929: 766: 690: 663: 630: 603: 566: 534: 507: 436: 364: 299: 279: 246: 213: 193: 160: 127: 95: 4844:Official statistics 4767:Methods engineering 4448:Seasonal adjustment 4216:Poisson regressions 4136:Bayesian regression 4075:Regression analysis 4055:Partial correlation 4027:Regression analysis 3626:Prediction interval 3621:Likelihood interval 3611:Confidence interval 3603:Interval estimation 3564:Unbiased estimators 3382:Model specification 3262:Up-and-down designs 2950:Partial correlation 2906:Index of dispersion 2824:Interquartile range 1255:{\displaystyle i=1} 1198: 1056:. It is defined as 996:to its expectation 4864:Spatial statistics 4744:Medical statistics 4644:First hitting time 4598:Whittle likelihood 4249:Degrees of freedom 4244:Multivariate ANOVA 4177:Heteroscedasticity 3989:Bayesian estimator 3954:Bayesian inference 3803:Kolmogorov–Smirnov 3688:Randomization test 3658:Testing hypotheses 3631:Tolerance interval 3542:Maximum likelihood 3437:Exponential family 3370:Density estimation 3330:Statistical theory 3290:Natural experiment 3236:Scientific control 3153:Survey methodology 2839:Standard deviation 2599:"The logrank test" 2500:10338.dmlcz/103602 2409:Mathematics portal 2353: 2296: 2267: 2247: 2191: 2148: 2094: 2040: 2013: 1986: 1946: 1919: 1892: 1872: 1845: 1818: 1797:Joint distribution 1783: 1756: 1729: 1637: 1611: 1591: 1541:{\displaystyle nd} 1538: 1515: 1495: 1475: 1455: 1435: 1408: 1375: 1347: 1327: 1307: 1272: 1252: 1226: 1046: 1019: 986: 953: 912: 752: 676: 649: 616: 585: 552: 520: 493: 415: 350: 295:. Finally, define 285: 265: 232: 199: 179: 146: 113: 63:and was named the 4979:Survival analysis 4966: 4965: 4904: 4903: 4900: 4899: 4839:National accounts 4809:Actuarial science 4801:Social statistics 4694: 4693: 4690: 4689: 4686: 4685: 4621:Survival function 4606: 4605: 4468:Granger causality 4309:Contingency table 4284:Survival analysis 4261: 4260: 4257: 4256: 4113:Linear regression 4008: 4007: 4004: 4003: 3979:Credible interval 3948: 3947: 3731: 3730: 3547:Method of moments 3416:Parametric family 3377:Statistical model 3307: 3306: 3303: 3302: 3221:Random assignment 3143:Statistical power 3077: 3076: 3073: 3072: 2922:Contingency table 2892: 2891: 2759:Generalized/power 2375:Peto logrank test 2351: 2328: 2293: 2270:{\displaystyle D} 2250:{\displaystyle Z} 2189: 2188: 2146: 2145: 2092: 2091: 1727: 1589: 1588: 1518:{\displaystyle d} 1498:{\displaystyle n} 1350:{\displaystyle J} 1330:{\displaystyle J} 1275:{\displaystyle 2} 1203: 1199: 1188: 1184: 1183: 906: 845: 750: 530:, for each group 288:{\displaystyle j} 202:{\displaystyle j} 4991: 4954: 4953: 4942: 4941: 4931: 4930: 4916: 4915: 4819:Crime statistics 4713: 4700: 4617: 4583:Fourier analysis 4570:Frequency domain 4550: 4497: 4463:Structural break 4423: 4372:Cluster analysis 4319:Log-linear model 4292: 4267: 4208: 4182:Homoscedasticity 4038: 4014: 3933: 3925: 3917: 3916:(Kruskal–Wallis) 3901: 3886: 3841:Cross validation 3826: 3808:Anderson–Darling 3755: 3742: 3713:Likelihood-ratio 3705:Parametric tests 3683:Permutation test 3666:1- & 2-tails 3557:Minimum distance 3529:Point estimation 3525: 3476:Optimal decision 3427: 3326: 3313: 3295:Quasi-experiment 3245:Adaptive designs 3096: 3083: 2960:Rank correlation 2722: 2713: 2700: 2667: 2660: 2653: 2644: 2637: 2636: 2626: 2587: 2581: 2580: 2552: 2546: 2545: 2519: 2513: 2512: 2502: 2471: 2462: 2461: 2438: 2411: 2406: 2405: 2382:Test assumptions 2362: 2360: 2359: 2354: 2352: 2347: 2339: 2330: 2329: 2321: 2305: 2303: 2302: 2297: 2295: 2294: 2286: 2276: 2274: 2273: 2268: 2256: 2254: 2253: 2248: 2200: 2198: 2197: 2192: 2190: 2187: 2186: 2177: 2176: 2167: 2166: 2158:and correlation 2157: 2155: 2154: 2149: 2147: 2141: 2140: 2139: 2125: 2124: 2121: 2103: 2101: 2100: 2095: 2093: 2087: 2086: 2085: 2071: 2070: 2067: 2049: 2047: 2046: 2041: 2039: 2038: 2022: 2020: 2019: 2014: 2012: 2011: 1995: 1993: 1992: 1987: 1985: 1984: 1972: 1971: 1955: 1953: 1952: 1947: 1945: 1944: 1928: 1926: 1925: 1920: 1918: 1917: 1901: 1899: 1898: 1893: 1881: 1879: 1878: 1873: 1871: 1870: 1854: 1852: 1851: 1846: 1844: 1843: 1827: 1825: 1824: 1819: 1817: 1816: 1792: 1790: 1789: 1784: 1782: 1781: 1765: 1763: 1762: 1757: 1755: 1754: 1738: 1736: 1735: 1730: 1728: 1726: 1725: 1717: 1716: 1703: 1702: 1701: 1692: 1691: 1679: 1678: 1661: 1646: 1644: 1643: 1638: 1621:test with power 1620: 1618: 1617: 1612: 1600: 1598: 1597: 1592: 1590: 1584: 1575: 1574: 1568: 1547: 1545: 1544: 1539: 1524: 1522: 1521: 1516: 1505:total subjects, 1504: 1502: 1501: 1496: 1484: 1482: 1481: 1476: 1464: 1462: 1461: 1456: 1444: 1442: 1441: 1436: 1434: 1433: 1417: 1415: 1414: 1409: 1407: 1406: 1384: 1382: 1381: 1376: 1356: 1354: 1353: 1348: 1336: 1334: 1333: 1328: 1316: 1314: 1313: 1308: 1306: 1305: 1281: 1279: 1278: 1273: 1261: 1259: 1258: 1253: 1235: 1233: 1232: 1227: 1210: 1209: 1201: 1200: 1190: 1186: 1185: 1182: 1181: 1165: 1160: 1145: 1144: 1140: 1139: 1121: 1120: 1101: 1096: 1080: 1075: 1074: 1055: 1053: 1052: 1047: 1045: 1044: 1028: 1026: 1025: 1020: 1018: 1017: 995: 993: 992: 987: 985: 984: 962: 960: 959: 954: 921: 919: 918: 913: 911: 907: 905: 898: 897: 887: 886: 885: 867: 866: 856: 850: 846: 844: 843: 834: 833: 832: 820: 819: 809: 803: 802: 784: 783: 761: 759: 758: 753: 751: 749: 748: 739: 738: 723: 721: 720: 708: 707: 685: 683: 682: 677: 675: 674: 658: 656: 655: 650: 648: 647: 625: 623: 622: 617: 615: 614: 599:with parameters 594: 592: 591: 586: 584: 583: 561: 559: 558: 553: 529: 527: 526: 521: 519: 518: 502: 500: 499: 494: 483: 482: 461: 460: 448: 447: 424: 422: 421: 416: 414: 413: 395: 394: 376: 375: 359: 357: 356: 351: 349: 348: 330: 329: 311: 310: 294: 292: 291: 286: 274: 272: 271: 266: 264: 263: 241: 239: 238: 233: 231: 230: 208: 206: 205: 200: 188: 186: 185: 180: 178: 177: 155: 153: 152: 147: 145: 144: 122: 120: 119: 114: 85:hazard functions 4999: 4998: 4994: 4993: 4992: 4990: 4989: 4988: 4969: 4968: 4967: 4962: 4925: 4896: 4858: 4795: 4781:quality control 4748: 4730:Clinical trials 4707: 4682: 4666: 4654:Hazard function 4648: 4602: 4564: 4548: 4511: 4507:Breusch–Godfrey 4495: 4472: 4412: 4387:Factor analysis 4333: 4314:Graphical model 4286: 4253: 4220: 4206: 4186: 4140: 4107: 4069: 4032: 4031: 4000: 3944: 3931: 3923: 3915: 3899: 3884: 3863:Rank statistics 3857: 3836:Model selection 3824: 3782:Goodness of fit 3776: 3753: 3727: 3699: 3652: 3597: 3586:Median unbiased 3514: 3425: 3358:Order statistic 3320: 3299: 3266: 3240: 3192: 3147: 3090: 3088:Data collection 3069: 2981: 2936: 2910: 2888: 2848: 2800: 2717:Continuous data 2707: 2694: 2676: 2671: 2641: 2640: 2589: 2588: 2584: 2554: 2553: 2549: 2542: 2521: 2520: 2516: 2491:10.2307/2344317 2473: 2472: 2465: 2440: 2439: 2435: 2430: 2407: 2400: 2397: 2384: 2370:is appropriate. 2308: 2307: 2279: 2278: 2259: 2258: 2239: 2238: 2211: 2178: 2168: 2160: 2159: 2131: 2126: 2106: 2105: 2077: 2072: 2052: 2051: 2030: 2025: 2024: 2003: 1998: 1997: 1976: 1963: 1958: 1957: 1936: 1931: 1930: 1909: 1904: 1903: 1884: 1883: 1862: 1857: 1856: 1835: 1830: 1829: 1808: 1803: 1802: 1799: 1773: 1768: 1767: 1746: 1741: 1740: 1708: 1704: 1693: 1683: 1670: 1662: 1649: 1648: 1623: 1622: 1603: 1602: 1576: 1550: 1549: 1527: 1526: 1507: 1506: 1487: 1486: 1467: 1466: 1447: 1446: 1425: 1420: 1419: 1398: 1387: 1386: 1367: 1366: 1363: 1339: 1338: 1319: 1318: 1297: 1292: 1291: 1264: 1263: 1238: 1237: 1167: 1125: 1106: 1081: 1066: 1061: 1060: 1036: 1031: 1030: 1003: 998: 997: 970: 965: 964: 927: 926: 889: 888: 871: 858: 857: 851: 835: 824: 811: 810: 804: 788: 769: 764: 763: 740: 724: 712: 693: 688: 687: 666: 661: 660: 633: 628: 627: 606: 601: 600: 569: 564: 563: 532: 531: 510: 505: 504: 503:. Hence, under 474: 452: 439: 434: 433: 430:null hypothesis 399: 380: 367: 362: 361: 334: 315: 302: 297: 296: 277: 276: 249: 244: 243: 216: 211: 210: 191: 190: 163: 158: 157: 130: 125: 124: 93: 92: 81: 50:Mantel–Cox test 45:clinical trials 31:to compare the 29:hypothesis test 17: 12: 11: 5: 4997: 4995: 4987: 4986: 4981: 4971: 4970: 4964: 4963: 4961: 4960: 4948: 4936: 4922: 4909: 4906: 4905: 4902: 4901: 4898: 4897: 4895: 4894: 4889: 4884: 4879: 4874: 4868: 4866: 4860: 4859: 4857: 4856: 4851: 4846: 4841: 4836: 4831: 4826: 4821: 4816: 4811: 4805: 4803: 4797: 4796: 4794: 4793: 4788: 4783: 4774: 4769: 4764: 4758: 4756: 4750: 4749: 4747: 4746: 4741: 4736: 4727: 4725:Bioinformatics 4721: 4719: 4709: 4708: 4703: 4696: 4695: 4692: 4691: 4688: 4687: 4684: 4683: 4681: 4680: 4674: 4672: 4668: 4667: 4665: 4664: 4658: 4656: 4650: 4649: 4647: 4646: 4641: 4636: 4631: 4625: 4623: 4614: 4608: 4607: 4604: 4603: 4601: 4600: 4595: 4590: 4585: 4580: 4574: 4572: 4566: 4565: 4563: 4562: 4557: 4552: 4544: 4539: 4534: 4533: 4532: 4530:partial (PACF) 4521: 4519: 4513: 4512: 4510: 4509: 4504: 4499: 4491: 4486: 4480: 4478: 4477:Specific tests 4474: 4473: 4471: 4470: 4465: 4460: 4455: 4450: 4445: 4440: 4435: 4429: 4427: 4420: 4414: 4413: 4411: 4410: 4409: 4408: 4407: 4406: 4391: 4390: 4389: 4379: 4377:Classification 4374: 4369: 4364: 4359: 4354: 4349: 4343: 4341: 4335: 4334: 4332: 4331: 4326: 4324:McNemar's test 4321: 4316: 4311: 4306: 4300: 4298: 4288: 4287: 4270: 4263: 4262: 4259: 4258: 4255: 4254: 4252: 4251: 4246: 4241: 4236: 4230: 4228: 4222: 4221: 4219: 4218: 4202: 4196: 4194: 4188: 4187: 4185: 4184: 4179: 4174: 4169: 4164: 4162:Semiparametric 4159: 4154: 4148: 4146: 4142: 4141: 4139: 4138: 4133: 4128: 4123: 4117: 4115: 4109: 4108: 4106: 4105: 4100: 4095: 4090: 4085: 4079: 4077: 4071: 4070: 4068: 4067: 4062: 4057: 4052: 4046: 4044: 4034: 4033: 4030: 4029: 4024: 4018: 4017: 4010: 4009: 4006: 4005: 4002: 4001: 3999: 3998: 3997: 3996: 3986: 3981: 3976: 3975: 3974: 3969: 3958: 3956: 3950: 3949: 3946: 3945: 3943: 3942: 3937: 3936: 3935: 3927: 3919: 3903: 3900:(Mann–Whitney) 3895: 3894: 3893: 3880: 3879: 3878: 3867: 3865: 3859: 3858: 3856: 3855: 3854: 3853: 3848: 3843: 3833: 3828: 3825:(Shapiro–Wilk) 3820: 3815: 3810: 3805: 3800: 3792: 3786: 3784: 3778: 3777: 3775: 3774: 3766: 3757: 3745: 3739: 3737:Specific tests 3733: 3732: 3729: 3728: 3726: 3725: 3720: 3715: 3709: 3707: 3701: 3700: 3698: 3697: 3692: 3691: 3690: 3680: 3679: 3678: 3668: 3662: 3660: 3654: 3653: 3651: 3650: 3649: 3648: 3643: 3633: 3628: 3623: 3618: 3613: 3607: 3605: 3599: 3598: 3596: 3595: 3590: 3589: 3588: 3583: 3582: 3581: 3576: 3561: 3560: 3559: 3554: 3549: 3544: 3533: 3531: 3522: 3516: 3515: 3513: 3512: 3507: 3502: 3501: 3500: 3490: 3485: 3484: 3483: 3473: 3472: 3471: 3466: 3461: 3451: 3446: 3441: 3440: 3439: 3434: 3429: 3413: 3412: 3411: 3406: 3401: 3391: 3390: 3389: 3384: 3374: 3373: 3372: 3362: 3361: 3360: 3350: 3345: 3340: 3334: 3332: 3322: 3321: 3316: 3309: 3308: 3305: 3304: 3301: 3300: 3298: 3297: 3292: 3287: 3282: 3276: 3274: 3268: 3267: 3265: 3264: 3259: 3254: 3248: 3246: 3242: 3241: 3239: 3238: 3233: 3228: 3223: 3218: 3213: 3208: 3202: 3200: 3194: 3193: 3191: 3190: 3188:Standard error 3185: 3180: 3175: 3174: 3173: 3168: 3157: 3155: 3149: 3148: 3146: 3145: 3140: 3135: 3130: 3125: 3120: 3118:Optimal design 3115: 3110: 3104: 3102: 3092: 3091: 3086: 3079: 3078: 3075: 3074: 3071: 3070: 3068: 3067: 3062: 3057: 3052: 3047: 3042: 3037: 3032: 3027: 3022: 3017: 3012: 3007: 3002: 2997: 2991: 2989: 2983: 2982: 2980: 2979: 2974: 2973: 2972: 2967: 2957: 2952: 2946: 2944: 2938: 2937: 2935: 2934: 2929: 2924: 2918: 2916: 2915:Summary tables 2912: 2911: 2909: 2908: 2902: 2900: 2894: 2893: 2890: 2889: 2887: 2886: 2885: 2884: 2879: 2874: 2864: 2858: 2856: 2850: 2849: 2847: 2846: 2841: 2836: 2831: 2826: 2821: 2816: 2810: 2808: 2802: 2801: 2799: 2798: 2793: 2788: 2787: 2786: 2781: 2776: 2771: 2766: 2761: 2756: 2751: 2749:Contraharmonic 2746: 2741: 2730: 2728: 2719: 2709: 2708: 2703: 2696: 2695: 2693: 2692: 2687: 2681: 2678: 2677: 2672: 2670: 2669: 2662: 2655: 2647: 2639: 2638: 2609:(7447): 1073. 2582: 2563:(1): 316–319. 2547: 2540: 2514: 2463: 2442:Mantel, Nathan 2432: 2431: 2429: 2426: 2425: 2424: 2419: 2413: 2412: 2396: 2393: 2383: 2380: 2379: 2378: 2371: 2364: 2350: 2346: 2342: 2336: 2333: 2327: 2324: 2318: 2315: 2292: 2289: 2266: 2246: 2235: 2227: 2210: 2207: 2185: 2181: 2175: 2171: 2144: 2138: 2134: 2129: 2120: 2116: 2113: 2090: 2084: 2080: 2075: 2066: 2062: 2059: 2037: 2033: 2010: 2006: 1983: 1979: 1975: 1970: 1966: 1943: 1939: 1916: 1912: 1891: 1869: 1865: 1842: 1838: 1815: 1811: 1798: 1795: 1780: 1776: 1753: 1749: 1724: 1720: 1715: 1711: 1707: 1700: 1696: 1690: 1686: 1682: 1677: 1673: 1669: 1665: 1659: 1656: 1636: 1633: 1630: 1610: 1587: 1583: 1579: 1571: 1567: 1563: 1560: 1557: 1537: 1534: 1514: 1494: 1474: 1454: 1432: 1428: 1405: 1401: 1397: 1394: 1374: 1362: 1359: 1346: 1326: 1304: 1300: 1284: 1283: 1271: 1251: 1248: 1245: 1225: 1222: 1219: 1216: 1213: 1208: 1197: 1193: 1180: 1177: 1174: 1170: 1164: 1159: 1156: 1153: 1149: 1143: 1138: 1135: 1132: 1128: 1124: 1119: 1116: 1113: 1109: 1105: 1100: 1095: 1092: 1089: 1085: 1078: 1073: 1069: 1043: 1039: 1016: 1013: 1010: 1006: 983: 980: 977: 973: 952: 949: 946: 943: 940: 937: 934: 910: 904: 901: 896: 892: 884: 881: 878: 874: 870: 865: 861: 854: 849: 842: 838: 831: 827: 823: 818: 814: 807: 801: 798: 795: 791: 787: 782: 779: 776: 772: 747: 743: 737: 734: 731: 727: 719: 715: 711: 706: 703: 700: 696: 673: 669: 646: 643: 640: 636: 613: 609: 582: 579: 576: 572: 551: 548: 545: 542: 539: 517: 513: 492: 489: 486: 481: 477: 473: 470: 467: 464: 459: 455: 451: 446: 442: 412: 409: 406: 402: 398: 393: 390: 387: 383: 379: 374: 370: 347: 344: 341: 337: 333: 328: 325: 322: 318: 314: 309: 305: 284: 262: 259: 256: 252: 229: 226: 223: 219: 198: 176: 173: 170: 166: 143: 140: 137: 133: 112: 109: 106: 103: 100: 80: 77: 15: 13: 10: 9: 6: 4: 3: 2: 4996: 4985: 4982: 4980: 4977: 4976: 4974: 4959: 4958: 4949: 4947: 4946: 4937: 4935: 4934: 4929: 4923: 4921: 4920: 4911: 4910: 4907: 4893: 4890: 4888: 4887:Geostatistics 4885: 4883: 4880: 4878: 4875: 4873: 4870: 4869: 4867: 4865: 4861: 4855: 4854:Psychometrics 4852: 4850: 4847: 4845: 4842: 4840: 4837: 4835: 4832: 4830: 4827: 4825: 4822: 4820: 4817: 4815: 4812: 4810: 4807: 4806: 4804: 4802: 4798: 4792: 4789: 4787: 4784: 4782: 4778: 4775: 4773: 4770: 4768: 4765: 4763: 4760: 4759: 4757: 4755: 4751: 4745: 4742: 4740: 4737: 4735: 4731: 4728: 4726: 4723: 4722: 4720: 4718: 4717:Biostatistics 4714: 4710: 4706: 4701: 4697: 4679: 4678:Log-rank test 4676: 4675: 4673: 4669: 4663: 4660: 4659: 4657: 4655: 4651: 4645: 4642: 4640: 4637: 4635: 4632: 4630: 4627: 4626: 4624: 4622: 4618: 4615: 4613: 4609: 4599: 4596: 4594: 4591: 4589: 4586: 4584: 4581: 4579: 4576: 4575: 4573: 4571: 4567: 4561: 4558: 4556: 4553: 4551: 4549:(Box–Jenkins) 4545: 4543: 4540: 4538: 4535: 4531: 4528: 4527: 4526: 4523: 4522: 4520: 4518: 4514: 4508: 4505: 4503: 4502:Durbin–Watson 4500: 4498: 4492: 4490: 4487: 4485: 4484:Dickey–Fuller 4482: 4481: 4479: 4475: 4469: 4466: 4464: 4461: 4459: 4458:Cointegration 4456: 4454: 4451: 4449: 4446: 4444: 4441: 4439: 4436: 4434: 4433:Decomposition 4431: 4430: 4428: 4424: 4421: 4419: 4415: 4405: 4402: 4401: 4400: 4397: 4396: 4395: 4392: 4388: 4385: 4384: 4383: 4380: 4378: 4375: 4373: 4370: 4368: 4365: 4363: 4360: 4358: 4355: 4353: 4350: 4348: 4345: 4344: 4342: 4340: 4336: 4330: 4327: 4325: 4322: 4320: 4317: 4315: 4312: 4310: 4307: 4305: 4304:Cohen's kappa 4302: 4301: 4299: 4297: 4293: 4289: 4285: 4281: 4277: 4273: 4268: 4264: 4250: 4247: 4245: 4242: 4240: 4237: 4235: 4232: 4231: 4229: 4227: 4223: 4217: 4213: 4209: 4203: 4201: 4198: 4197: 4195: 4193: 4189: 4183: 4180: 4178: 4175: 4173: 4170: 4168: 4165: 4163: 4160: 4158: 4157:Nonparametric 4155: 4153: 4150: 4149: 4147: 4143: 4137: 4134: 4132: 4129: 4127: 4124: 4122: 4119: 4118: 4116: 4114: 4110: 4104: 4101: 4099: 4096: 4094: 4091: 4089: 4086: 4084: 4081: 4080: 4078: 4076: 4072: 4066: 4063: 4061: 4058: 4056: 4053: 4051: 4048: 4047: 4045: 4043: 4039: 4035: 4028: 4025: 4023: 4020: 4019: 4015: 4011: 3995: 3992: 3991: 3990: 3987: 3985: 3982: 3980: 3977: 3973: 3970: 3968: 3965: 3964: 3963: 3960: 3959: 3957: 3955: 3951: 3941: 3938: 3934: 3928: 3926: 3920: 3918: 3912: 3911: 3910: 3907: 3906:Nonparametric 3904: 3902: 3896: 3892: 3889: 3888: 3887: 3881: 3877: 3876:Sample median 3874: 3873: 3872: 3869: 3868: 3866: 3864: 3860: 3852: 3849: 3847: 3844: 3842: 3839: 3838: 3837: 3834: 3832: 3829: 3827: 3821: 3819: 3816: 3814: 3811: 3809: 3806: 3804: 3801: 3799: 3797: 3793: 3791: 3788: 3787: 3785: 3783: 3779: 3773: 3771: 3767: 3765: 3763: 3758: 3756: 3751: 3747: 3746: 3743: 3740: 3738: 3734: 3724: 3721: 3719: 3716: 3714: 3711: 3710: 3708: 3706: 3702: 3696: 3693: 3689: 3686: 3685: 3684: 3681: 3677: 3674: 3673: 3672: 3669: 3667: 3664: 3663: 3661: 3659: 3655: 3647: 3644: 3642: 3639: 3638: 3637: 3634: 3632: 3629: 3627: 3624: 3622: 3619: 3617: 3614: 3612: 3609: 3608: 3606: 3604: 3600: 3594: 3591: 3587: 3584: 3580: 3577: 3575: 3572: 3571: 3570: 3567: 3566: 3565: 3562: 3558: 3555: 3553: 3550: 3548: 3545: 3543: 3540: 3539: 3538: 3535: 3534: 3532: 3530: 3526: 3523: 3521: 3517: 3511: 3508: 3506: 3503: 3499: 3496: 3495: 3494: 3491: 3489: 3486: 3482: 3481:loss function 3479: 3478: 3477: 3474: 3470: 3467: 3465: 3462: 3460: 3457: 3456: 3455: 3452: 3450: 3447: 3445: 3442: 3438: 3435: 3433: 3430: 3428: 3422: 3419: 3418: 3417: 3414: 3410: 3407: 3405: 3402: 3400: 3397: 3396: 3395: 3392: 3388: 3385: 3383: 3380: 3379: 3378: 3375: 3371: 3368: 3367: 3366: 3363: 3359: 3356: 3355: 3354: 3351: 3349: 3346: 3344: 3341: 3339: 3336: 3335: 3333: 3331: 3327: 3323: 3319: 3314: 3310: 3296: 3293: 3291: 3288: 3286: 3283: 3281: 3278: 3277: 3275: 3273: 3269: 3263: 3260: 3258: 3255: 3253: 3250: 3249: 3247: 3243: 3237: 3234: 3232: 3229: 3227: 3224: 3222: 3219: 3217: 3214: 3212: 3209: 3207: 3204: 3203: 3201: 3199: 3195: 3189: 3186: 3184: 3183:Questionnaire 3181: 3179: 3176: 3172: 3169: 3167: 3164: 3163: 3162: 3159: 3158: 3156: 3154: 3150: 3144: 3141: 3139: 3136: 3134: 3131: 3129: 3126: 3124: 3121: 3119: 3116: 3114: 3111: 3109: 3106: 3105: 3103: 3101: 3097: 3093: 3089: 3084: 3080: 3066: 3063: 3061: 3058: 3056: 3053: 3051: 3048: 3046: 3043: 3041: 3038: 3036: 3033: 3031: 3028: 3026: 3023: 3021: 3018: 3016: 3013: 3011: 3010:Control chart 3008: 3006: 3003: 3001: 2998: 2996: 2993: 2992: 2990: 2988: 2984: 2978: 2975: 2971: 2968: 2966: 2963: 2962: 2961: 2958: 2956: 2953: 2951: 2948: 2947: 2945: 2943: 2939: 2933: 2930: 2928: 2925: 2923: 2920: 2919: 2917: 2913: 2907: 2904: 2903: 2901: 2899: 2895: 2883: 2880: 2878: 2875: 2873: 2870: 2869: 2868: 2865: 2863: 2860: 2859: 2857: 2855: 2851: 2845: 2842: 2840: 2837: 2835: 2832: 2830: 2827: 2825: 2822: 2820: 2817: 2815: 2812: 2811: 2809: 2807: 2803: 2797: 2794: 2792: 2789: 2785: 2782: 2780: 2777: 2775: 2772: 2770: 2767: 2765: 2762: 2760: 2757: 2755: 2752: 2750: 2747: 2745: 2742: 2740: 2737: 2736: 2735: 2732: 2731: 2729: 2727: 2723: 2720: 2718: 2714: 2710: 2706: 2701: 2697: 2691: 2688: 2686: 2683: 2682: 2679: 2675: 2668: 2663: 2661: 2656: 2654: 2649: 2648: 2645: 2634: 2630: 2625: 2620: 2616: 2612: 2608: 2604: 2600: 2596: 2595:Altman, D. G. 2592: 2586: 2583: 2578: 2574: 2570: 2566: 2562: 2558: 2551: 2548: 2543: 2537: 2533: 2529: 2525: 2518: 2515: 2510: 2506: 2501: 2496: 2492: 2488: 2484: 2480: 2476: 2475:Peto, Richard 2470: 2468: 2464: 2459: 2455: 2452:(3): 163–70. 2451: 2447: 2443: 2437: 2434: 2427: 2423: 2420: 2418: 2415: 2414: 2410: 2404: 2399: 2394: 2392: 2389: 2381: 2376: 2372: 2369: 2365: 2348: 2344: 2340: 2334: 2331: 2322: 2316: 2313: 2287: 2264: 2244: 2236: 2233: 2228: 2225: 2221: 2217: 2213: 2212: 2208: 2206: 2204: 2183: 2179: 2173: 2169: 2142: 2136: 2132: 2127: 2118: 2114: 2111: 2088: 2082: 2078: 2073: 2064: 2060: 2057: 2035: 2031: 2008: 2004: 1981: 1977: 1973: 1968: 1964: 1941: 1937: 1914: 1910: 1889: 1867: 1863: 1840: 1836: 1813: 1809: 1796: 1794: 1778: 1774: 1751: 1747: 1722: 1718: 1713: 1709: 1705: 1698: 1688: 1684: 1680: 1675: 1671: 1663: 1657: 1654: 1634: 1631: 1628: 1608: 1585: 1581: 1577: 1565: 1561: 1558: 1535: 1532: 1512: 1492: 1472: 1452: 1445:is the upper 1430: 1426: 1403: 1399: 1395: 1392: 1372: 1360: 1358: 1344: 1324: 1302: 1298: 1289: 1269: 1249: 1246: 1243: 1220: 1217: 1214: 1195: 1191: 1178: 1175: 1172: 1168: 1162: 1157: 1154: 1151: 1147: 1136: 1133: 1130: 1126: 1122: 1117: 1114: 1111: 1107: 1098: 1093: 1090: 1087: 1083: 1076: 1071: 1067: 1059: 1058: 1057: 1041: 1037: 1014: 1011: 1008: 1004: 981: 978: 975: 971: 950: 947: 944: 941: 938: 935: 932: 923: 908: 902: 899: 894: 890: 882: 879: 876: 872: 868: 863: 859: 852: 847: 840: 836: 829: 825: 821: 816: 812: 805: 799: 796: 793: 789: 785: 780: 777: 774: 770: 762:and variance 745: 741: 735: 732: 729: 725: 717: 713: 709: 704: 701: 698: 694: 671: 667: 644: 641: 638: 634: 611: 607: 598: 580: 577: 574: 570: 549: 546: 543: 540: 537: 515: 511: 487: 479: 475: 471: 465: 457: 453: 449: 444: 440: 431: 426: 410: 407: 404: 400: 396: 391: 388: 385: 381: 377: 372: 368: 345: 342: 339: 335: 331: 326: 323: 320: 316: 312: 307: 303: 282: 260: 257: 254: 250: 227: 224: 221: 217: 196: 174: 171: 168: 164: 141: 138: 135: 131: 110: 107: 104: 101: 98: 89: 86: 78: 76: 74: 70: 66: 62: 61:Nathan Mantel 57: 55: 51: 46: 42: 38: 37:nonparametric 34: 30: 26: 25:log-rank test 22: 4955: 4943: 4924: 4917: 4829:Econometrics 4779: / 4762:Chemometrics 4739:Epidemiology 4732: / 4705:Applications 4547:ARIMA model 4494:Q-statistic 4443:Stationarity 4339:Multivariate 4282: / 4278: / 4276:Multivariate 4274: / 4214: / 4210: / 3984:Bayes factor 3883:Signed rank 3795: 3769: 3761: 3749: 3444:Completeness 3280:Cohort study 3178:Opinion poll 3113:Missing data 3100:Study design 3055:Scatter plot 2977:Scatter plot 2970:Spearman's ρ 2932:Grouped data 2606: 2602: 2591:Bland, J. M. 2585: 2560: 2556: 2550: 2523: 2517: 2482: 2478: 2449: 2445: 2436: 2422:Hazard ratio 2388:Kaplan-Meier 2385: 1800: 1485:, there are 1364: 1285: 924: 427: 90: 82: 65:logrank test 64: 58: 49: 24: 21:logrank test 20: 18: 4957:WikiProject 4872:Cartography 4834:Jurimetrics 4786:Reliability 4517:Time domain 4496:(Ljung–Box) 4418:Time-series 4296:Categorical 4280:Time-series 4272:Categorical 4207:(Bernoulli) 4042:Correlation 4022:Correlation 3818:Jarque–Bera 3790:Chi-squared 3552:M-estimator 3505:Asymptotics 3449:Sufficiency 3216:Interaction 3128:Replication 3108:Effect size 3065:Violin plot 3045:Radar chart 3025:Forest plot 3015:Correlogram 2965:Kendall's τ 73:Julian Peto 4973:Categories 4824:Demography 4542:ARMA model 4347:Regression 3924:(Friedman) 3885:(Wilcoxon) 3823:Normality 3813:Lilliefors 3760:Student's 3636:Resampling 3510:Robustness 3498:divergence 3488:Efficiency 3426:(monotone) 3421:Likelihood 3338:Population 3171:Stratified 3123:Population 2942:Dependence 2898:Count data 2829:Percentile 2806:Dispersion 2739:Arithmetic 2674:Statistics 2557:Biometrika 2541:047084907X 2428:References 2216:score test 595:follows a 79:Definition 4205:Logistic 3972:posterior 3898:Rank sum 3646:Jackknife 3641:Bootstrap 3459:Bootstrap 3394:Parameter 3343:Statistic 3138:Statistic 3050:Run chart 3035:Pie chart 3030:Histogram 3020:Fan chart 2995:Bar chart 2877:L-moments 2764:Geometric 2332:≈ 2326:^ 2323:λ 2317:⁡ 2291:^ 2288:λ 2119:λ 2115:⁡ 2065:λ 2061:⁡ 1974:≤ 1890:λ 1779:β 1752:α 1723:λ 1719:⁡ 1689:β 1676:α 1635:β 1632:− 1609:α 1566:λ 1562:⁡ 1473:λ 1453:α 1431:α 1404:α 1373:α 1148:∑ 1123:− 1084:∑ 945:… 900:− 869:− 822:− 105:… 4919:Category 4612:Survival 4489:Johansen 4212:Binomial 4167:Isotonic 3754:(normal) 3399:location 3206:Blocking 3161:Sampling 3040:Q–Q plot 3005:Box plot 2987:Graphics 2882:Skewness 2872:Kurtosis 2844:Variance 2774:Heronian 2769:Harmonic 2633:15117797 2597:(2004). 2395:See also 2218:for the 1801:Suppose 1192:→ 925:For all 41:censored 33:survival 4945:Commons 4892:Kriging 4777:Process 4734:studies 4593:Wavelet 4426:General 3593:Plug-in 3387:L space 3166:Cluster 2867:Moments 2685:Outline 2577:2335833 2509:2344317 2458:5910392 1286:By the 69:Richard 27:, is a 4814:Census 4404:Normal 4352:Manova 4172:Robust 3922:2-way 3914:1-way 3752:-test 3423:  3000:Biplot 2791:Median 2784:Lehmer 2726:Center 2631:  2624:403858 2621:  2575:  2538:  2507:  2456:  1739:where 1418:where 1202:  1187:  1029:under 4438:Trend 3967:prior 3909:anova 3798:-test 3772:-test 3764:-test 3671:Power 3616:Pivot 3409:shape 3404:scale 2854:Shape 2834:Range 2779:Heinz 2754:Cubic 2690:Index 2573:JSTOR 2505:JSTOR 23:, or 4671:Test 3871:Sign 3723:Wald 2796:Mode 2734:Mean 2629:PMID 2536:ISBN 2454:PMID 2104:and 2023:and 1929:and 1902:and 1828:and 1766:and 1396:> 428:The 360:and 242:and 156:and 71:and 19:The 3851:BIC 3846:AIC 2619:PMC 2611:doi 2607:328 2603:BMJ 2565:doi 2528:doi 2495:hdl 2487:doi 2483:135 2314:log 2237:If 2112:log 2058:log 1996:. 1710:log 1559:log 1262:or 67:by 4975:: 2627:. 2617:. 2605:. 2601:. 2593:; 2571:. 2561:68 2559:. 2534:. 2503:. 2493:. 2481:. 2466:^ 2450:50 2448:. 2205:. 922:. 659:, 626:, 562:, 425:. 75:. 56:. 3796:G 3770:F 3762:t 3750:Z 3469:V 3464:U 2666:e 2659:t 2652:v 2635:. 2613:: 2579:. 2567:: 2544:. 2530:: 2511:. 2497:: 2489:: 2460:. 2349:D 2345:/ 2341:4 2335:Z 2265:D 2245:Z 2234:. 2184:2 2180:d 2174:1 2170:d 2143:4 2137:2 2133:d 2128:n 2089:4 2083:1 2079:d 2074:n 2036:2 2032:Z 2009:1 2005:Z 1982:2 1978:d 1969:1 1965:d 1942:2 1938:d 1915:1 1911:d 1868:1 1864:Z 1841:2 1837:Z 1814:1 1810:Z 1775:z 1748:z 1714:2 1706:d 1699:2 1695:) 1685:z 1681:+ 1672:z 1668:( 1664:4 1658:= 1655:n 1629:1 1586:4 1582:d 1578:n 1570:) 1556:( 1536:d 1533:n 1513:d 1493:n 1427:z 1400:z 1393:Z 1345:J 1325:J 1303:i 1299:Z 1282:) 1270:2 1250:1 1247:= 1244:i 1224:) 1221:1 1218:, 1215:0 1212:( 1207:N 1196:d 1179:j 1176:, 1173:i 1169:V 1163:J 1158:1 1155:= 1152:j 1142:) 1137:j 1134:, 1131:i 1127:E 1118:j 1115:, 1112:i 1108:O 1104:( 1099:J 1094:1 1091:= 1088:j 1077:= 1072:i 1068:Z 1042:0 1038:H 1015:j 1012:, 1009:i 1005:E 982:j 979:, 976:i 972:O 951:J 948:, 942:, 939:1 936:= 933:j 909:) 903:1 895:j 891:N 883:j 880:, 877:i 873:N 864:j 860:N 853:( 848:) 841:j 837:N 830:j 826:O 817:j 813:N 806:( 800:j 797:, 794:i 790:E 786:= 781:j 778:, 775:i 771:V 746:j 742:N 736:j 733:, 730:i 726:N 718:j 714:O 710:= 705:j 702:, 699:i 695:E 672:j 668:O 645:j 642:, 639:i 635:N 612:j 608:N 581:j 578:, 575:i 571:O 550:2 547:, 544:1 541:= 538:i 516:0 512:H 491:) 488:t 485:( 480:2 476:h 472:= 469:) 466:t 463:( 458:1 454:h 450:: 445:0 441:H 411:j 408:, 405:2 401:O 397:+ 392:j 389:, 386:1 382:O 378:= 373:j 369:O 346:j 343:, 340:2 336:N 332:+ 327:j 324:, 321:1 317:N 313:= 308:j 304:N 283:j 261:j 258:, 255:2 251:O 228:j 225:, 222:1 218:O 197:j 175:j 172:, 169:2 165:N 142:j 139:, 136:1 132:N 111:J 108:, 102:, 99:1

Index

hypothesis test
survival
nonparametric
censored
clinical trials
Cochran–Mantel–Haenszel test
Nathan Mantel
Richard
Julian Peto
hazard functions
null hypothesis
hypergeometric distribution
central limit theorem
Data Monitoring Committee
score test
Cox proportional hazards model
likelihood ratio test
exponential distributions
Wilcoxon rank sum test
Peto logrank test
Kaplan-Meier
icon
Mathematics portal
Kaplan–Meier estimator
Hazard ratio
Mantel, Nathan
PMID
5910392

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.

↑