299:
276:
173:
198:
2725:
305:
204:
1207:. The structure was resolved using X-ray crystallography at 2.1 Angstrom resolution. It contains an element in the C-terminal region referred to as a "gatekeeper" helix, which is adjacent to the membrane-anchored transmembrane domain and the catalytic core. The gatekeeper helix appears to control access of molecular substrates to the catalytic core and allows efficient transit between membranes and catalytic sites.
2705:
1215:
ALDH3A2 catalyzes the oxidation of long-chain aliphatic aldehydes into fatty acids. It is known to act on a variety of both saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length, as well as dihydrophytal, a 20-carbon branched chain aldehyde. It requires
52:
2215:
2347:
1821:
312:
211:
1263:
neurocutaneous disease. Multiple mutations have been found in different families, including those that molecularly disrupts the protein dimerization interface or reduces
1243:
isoforms of ALDH3A2 are known to exist. The alternative transcript differs by an additional exon and anchors differently to the endoplasmic reticulum vs. the peroxisome
1616:
1267:
stability. Absence or insufficiency of ALDH3A2 protein products in mutant cells are known to cause abnormal metabolism of sphingosine 1-phosphate to ether-linked
2271:
1457:
Kelson TL, Secor McVoy JR, Rizzo WB (1997). "Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization".
1422:
Kelson TL, Secor McVoy JR, Rizzo WB (1997). "Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization".
2766:
2246:
1781:
2208:
1771:
1756:
1751:
1746:
1715:
834:
134:
815:
1788:
1814:
2785:
2201:
1609:
1365:
Keller MA, Zander U, Fuchs JE, Kreutz C, Watschinger K, Mueller T, Golderer G, Liedl KR, Ralser M, Kräutler B, Werner ER, Marquez JA (2014).
1347:
1799:
2137:
1329:
298:
49:
2059:
1992:
2337:
2293:
1951:
1106:
1113:
275:
2759:
2424:
2242:
1997:
1807:
1987:
1602:
2063:
1316:
1295:
1200:
2367:
1979:
197:
172:
2580:
1312:
2795:
1533:"The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway"
2695:
1367:"A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase"
1291:
2752:
2080:
114:
311:
210:
1911:
1906:
1256:
304:
203:
2259:
1901:
2565:
2681:
2668:
2655:
2642:
2629:
2616:
2603:
2379:
2325:
2303:
2281:
2238:
2160:
2121:
2103:
1935:
2575:
2529:
2472:
2229:
1629:
1588:
879:
122:
2383:
1584:
2477:
1956:
1225:
1221:
860:
105:, aldehyde dehydrogenase 3 family, member A2, ALDH10, FALDH, SLS, aldehyde dehydrogenase 3 family member A2
2342:
2254:
2022:
1970:
1878:
1625:
1203:
and is a membrane-associated protein typically containing 485 residues. The mature protein functions as a
1197:
1181:
1173:
2498:
2417:
1838:
186:
2570:
1888:
1378:
1240:
2534:
2098:
2052:
1916:
1893:
1260:
1085:
1081:
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1056:
1052:
1042:
1038:
1034:
1030:
1006:
1002:
977:
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969:
959:
955:
951:
947:
101:
2467:
146:
1089:
1026:
998:
943:
608:
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
2790:
2391:
1873:
1564:
1513:
1474:
1439:
1404:
94:
42:
2736:
1228:(S1P) degradation product hexadecenal to hexadecenoic acid. ALD3H2 is expressed in the human
142:
2513:
2508:
2482:
2410:
2315:
1834:
1554:
1544:
1505:
1494:"Genomic organization and expression of the human fatty aldehyde dehydrogenase gene (FALDH)"
1466:
1431:
1394:
1386:
391:
322:
266:
221:
2560:
2544:
2457:
1531:
Nakahara K, Ohkuni A, Kitamura T, Abe K, Naganuma T, Ohno Y, Zoeller RA, Kihara A (2012).
366:
2193:
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2225:
2113:
2090:
2007:
1399:
1366:
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1470:
1435:
749:
744:
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729:
724:
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627:
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587:
582:
2779:
2503:
2462:
1690:
1594:
1268:
1204:
569:
126:
2452:
1842:
384:
163:
1549:
1532:
150:
2676:
2611:
2447:
1864:
1352:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1334:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2704:
467:
2362:
2285:
2152:
1927:
1846:
1830:
623:
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
283:
180:
130:
2650:
2624:
2329:
1233:
1185:
779:
527:
405:
350:
337:
249:
236:
138:
1568:
1509:
1408:
1188:
that are generated by the metabolism of alcohol and by lipid peroxidation.
1517:
1478:
1443:
1153:
2170:
1776:
1137:
924:
905:
1148:
1766:
1761:
1730:
1725:
1677:
1672:
1664:
1657:
1652:
1647:
1390:
891:
846:
1559:
71:
2663:
2433:
2357:
2352:
2307:
2046:
2041:
1849:
1121:
801:
1493:
1492:
Rogers GR, Markova NG, De
Laurenzi V, Rizzo WB, Compton JG (1997).
1217:
2637:
2073:
2068:
2036:
2031:
2026:
1699:
1229:
764:
760:
1264:
118:
2406:
2197:
1803:
1598:
1255:
gene have been widely associated with the autosomal recessive
2402:
1224:. The encoded enzyme is responsible for conversion of the
374:
2740:
2693:
539:
2348:
Branched-chain alpha-keto acid dehydrogenase complex
2589:
2553:
2522:
2491:
2440:
2378:
2324:
2302:
2280:
2237:
2169:
2150:
2130:
2112:
2089:
2015:
2006:
1978:
1969:
1944:
1925:
1887:
1863:
1856:
1739:
1708:
1688:
1637:
1271:and the abnormal accumulation of lipid precursors.
1074:
1025:
991:
942:
1308:
1306:
1304:
1287:
1285:
1283:
321:
220:
16:Protein-coding gene in the species Homo sapiens
2272:Mycothiol-dependent formaldehyde dehydrogenase
1313:GRCm38: Ensembl release 89: ENSMUSG00000010025
2760:
2418:
2209:
1815:
1610:
628:3-chloroallyl aldehyde dehydrogenase activity
8:
593:medium-chain-aldehyde dehydrogenase activity
1292:GRCh38: Ensembl release 89: ENSG00000072210
2767:
2753:
2425:
2411:
2403:
2216:
2202:
2194:
2012:
1975:
1860:
1822:
1808:
1800:
1617:
1603:
1595:
1022:
939:
775:
583:long-chain-aldehyde dehydrogenase activity
565:
362:
261:
158:
60:
1587:at the U.S. National Library of Medicine
1558:
1548:
1398:
659:intracellular membrane-bounded organelle
2700:
1279:
1176:enzyme that in human is encoded in the
1762:α-Aminoadipic semialdehyde — (ALDH7A1)
603:aldehyde dehydrogenase (NAD+) activity
20:
695:peripheral nervous system development
326:
287:
282:
225:
184:
179:
7:
2721:
2719:
2138:Hydroxyacyl-Coenzyme A dehydrogenase
1789:Glyceraldehyde 3-phosphate — (GAPDH)
1993:Carnitine-acylcarnitine translocase
1716:Dimeric NADP-preferring — (ALDH3A1)
1251:Mutations and deletions within the
1232:and has been found to localize the
715:cellular aldehyde metabolic process
588:long-chain-alcohol oxidase activity
2739:. You can help Knowledge (XXG) by
2338:Oxoglutarate dehydrogenase complex
2294:Formate dehydrogenase (cytochrome)
1952:Glycerol-3-phosphate dehydrogenase
1071:
988:
915:
896:
870:
851:
825:
806:
720:central nervous system development
544:
462:
400:
379:
14:
2265:Long-chain-aldehyde dehydrogenase
2179:Long-chain-aldehyde dehydrogenase
1998:Carnitine palmitoyltransferase II
1585:long-chain-aldehyde+dehydrogenase
1184:enzymes function to remove toxic
1170:long-chain-aldehyde dehydrogenase
710:sphingolipid biosynthetic process
700:sesquiterpenoid metabolic process
618:protein homodimerization activity
2723:
2703:
1988:Carnitine palmitoyltransferase I
310:
303:
297:
274:
209:
202:
196:
171:
649:endoplasmic reticulum membrane
644:integral component of membrane
528:More reference expression data
1:
1471:10.1016/s0304-4165(96)00126-2
1436:10.1016/s0304-4165(96)00126-2
740:hexadecanal metabolic process
295:
194:
2786:Genes on human chromosome 17
2081:Acetyl-CoA C-acyltransferase
1550:10.1016/j.molcel.2012.04.033
1166:Fatty aldehyde dehydrogenase
750:fatty acid metabolic process
1912:3-Hydroxyacyl ACP dehydrase
2812:
2718:
2260:Acetaldehyde dehydrogenase
1902:Beta-ketoacyl-ACP synthase
1721:Fatty aldehyde — (ALDH3A2)
1236:fraction inside the cell.
735:fatty acid alpha-oxidation
2581:Michaelis–Menten kinetics
2161:Malonyl-CoA decarboxylase
2122:Propionyl-CoA carboxylase
2104:2,4 Dienoyl-CoA reductase
1936:Stearoyl-CoA desaturase-1
1669:Formyltetrahydrofolate —
1348:"Mouse PubMed Reference:"
1330:"Human PubMed Reference:"
1152:
1147:
1143:
1136:
1120:
1101:
1078:
1049:
1018:
995:
966:
935:
922:
918:
903:
899:
890:
877:
873:
858:
854:
845:
832:
828:
813:
809:
800:
785:
778:
774:
758:
568:
564:
552:
547:
538:
525:
474:
465:
412:
403:
373:
365:
361:
344:
331:
294:
273:
264:
260:
243:
230:
193:
170:
161:
157:
112:
109:
99:
92:
87:
68:
63:
46:
41:
36:
32:
28:
23:
2473:Diffusion-limited enzyme
1907:Î’-Ketoacyl ACP reductase
1589:Medical Subject Headings
1257:Sjögren-Larsson syndrome
1180:gene on chromosome 17.
1114:Chr 11: 61.11 – 61.16 Mb
1107:Chr 17: 19.65 – 19.69 Mb
705:phytol metabolic process
1626:Aldehyde dehydrogenases
1226:sphingosine 1-phosphate
1196:ALDH3A2 belongs to the
598:oxidoreductase activity
2343:Pyruvate dehydrogenase
2255:Aldehyde dehydrogenase
2023:Acyl CoA dehydrogenase
1879:Acetyl-CoA carboxylase
1510:10.1006/geno.1996.4501
1459:Biochim. Biophys. Acta
1424:Biochim. Biophys. Acta
1198:aldehyde dehydrogenase
1182:Aldehyde dehydrogenase
1174:aldehyde dehydrogenase
494:mucous cell of stomach
328:11 B2|11 37.96 cM
2566:Eadie–Hofstee diagram
2499:Allosteric regulation
1839:fatty acid metabolism
1247:Clinical significance
725:epidermis development
669:endoplasmic reticulum
289:Chromosome 11 (mouse)
187:Chromosome 17 (human)
2796:Oxidoreductase stubs
2576:Lineweaver–Burk plot
1889:Fatty acid synthesis
1241:alternative splicing
674:peroxisomal membrane
416:right adrenal cortex
64:List of PDB id codes
37:Available structures
2384:iron–sulfur protein
2099:Enoyl CoA isomerase
2053:Enoyl-CoA hydratase
1917:Enoyl ACP reductase
1894:Fatty acid synthase
1383:2014NatCo...5.4439K
1261:autosomal recessive
424:left adrenal cortex
151:ALDH3A2 - orthologs
2535:Enzyme superfamily
2468:Enzyme promiscuity
1391:10.1038/ncomms5439
880:ENSMUSG00000010025
688:Biological process
679:organelle membrane
637:Cellular component
576:Molecular function
482:left lobe of liver
420:left adrenal gland
2748:
2747:
2691:
2690:
2400:
2399:
2392:Pyruvate synthase
2191:
2190:
2187:
2186:
2146:
2145:
1965:
1964:
1874:ATP citrate lyase
1797:
1796:
1163:
1162:
1159:
1158:
1132:
1131:
1097:
1096:
1068:
1067:
1014:
1013:
985:
984:
931:
930:
912:
911:
886:
885:
867:
866:
841:
840:
822:
821:
770:
769:
560:
559:
556:
555:
534:
533:
521:
520:
459:
458:
357:
356:
256:
255:
83:
82:
79:
78:
47:Ortholog search:
2803:
2769:
2762:
2755:
2727:
2720:
2708:
2707:
2699:
2571:Hanes–Woolf plot
2514:Enzyme activator
2509:Enzyme inhibitor
2483:Enzyme catalysis
2427:
2420:
2413:
2404:
2316:Aldehyde oxidase
2218:
2211:
2204:
2195:
2013:
1976:
1945:Triacyl glycerol
1861:
1835:lipid metabolism
1824:
1817:
1810:
1801:
1644:Retinaldehyde —
1619:
1612:
1605:
1596:
1573:
1572:
1562:
1552:
1528:
1522:
1521:
1489:
1483:
1482:
1454:
1448:
1447:
1419:
1413:
1412:
1402:
1362:
1356:
1355:
1344:
1338:
1337:
1326:
1320:
1310:
1299:
1289:
1145:
1144:
1116:
1109:
1092:
1072:
1063:
1023:
1019:RefSeq (protein)
1009:
989:
980:
940:
916:
897:
871:
852:
826:
807:
776:
745:lipid metabolism
566:
545:
530:
470:
468:Top expressed in
463:
408:
406:Top expressed in
401:
380:
363:
353:
340:
329:
314:
307:
301:
290:
278:
262:
252:
239:
228:
213:
206:
200:
189:
175:
159:
153:
104:
97:
74:
61:
55:
34:
33:
21:
2811:
2810:
2806:
2805:
2804:
2802:
2801:
2800:
2776:
2775:
2774:
2773:
2716:
2714:
2702:
2694:
2692:
2687:
2599:Oxidoreductases
2585:
2561:Enzyme kinetics
2549:
2545:List of enzymes
2518:
2487:
2458:Catalytic triad
2436:
2431:
2401:
2396:
2374:
2320:
2298:
2276:
2233:
2226:oxidoreductases
2222:
2192:
2183:
2165:
2142:
2126:
2108:
2085:
2002:
1961:
1940:
1921:
1892:
1883:
1852:
1828:
1798:
1793:
1735:
1704:
1684:
1633:
1623:
1581:
1579:Further reading
1576:
1530:
1529:
1525:
1491:
1490:
1486:
1465:(1–2): 99–110.
1456:
1455:
1451:
1430:(1–2): 99–110.
1421:
1420:
1416:
1364:
1363:
1359:
1346:
1345:
1341:
1328:
1327:
1323:
1311:
1302:
1290:
1281:
1277:
1249:
1213:
1194:
1154:View/Edit Mouse
1149:View/Edit Human
1112:
1105:
1102:Location (UCSC)
1088:
1084:
1080:
1059:
1055:
1051:
1045:
1041:
1037:
1033:
1029:
1005:
1001:
997:
976:
972:
968:
962:
958:
954:
950:
946:
861:ENSG00000072210
754:
683:
632:
613:protein binding
526:
517:
512:
508:
504:
500:
496:
492:
488:
484:
480:
466:
455:
450:
446:
442:
438:
436:skin of abdomen
434:
430:
426:
422:
418:
404:
348:
335:
327:
317:
316:
315:
308:
288:
265:Gene location (
247:
234:
226:
216:
215:
214:
207:
185:
162:Gene location (
113:
100:
93:
70:
48:
17:
12:
11:
5:
2809:
2807:
2799:
2798:
2793:
2788:
2778:
2777:
2772:
2771:
2764:
2757:
2749:
2746:
2745:
2733:oxidoreductase
2728:
2713:
2712:
2689:
2688:
2686:
2685:
2672:
2659:
2646:
2633:
2620:
2607:
2593:
2591:
2587:
2586:
2584:
2583:
2578:
2573:
2568:
2563:
2557:
2555:
2551:
2550:
2548:
2547:
2542:
2537:
2532:
2526:
2524:
2523:Classification
2520:
2519:
2517:
2516:
2511:
2506:
2501:
2495:
2493:
2489:
2488:
2486:
2485:
2480:
2475:
2470:
2465:
2460:
2455:
2450:
2444:
2442:
2438:
2437:
2432:
2430:
2429:
2422:
2415:
2407:
2398:
2397:
2395:
2394:
2388:
2386:
2376:
2375:
2373:
2372:
2371:
2370:
2365:
2360:
2355:
2345:
2340:
2334:
2332:
2322:
2321:
2319:
2318:
2312:
2310:
2300:
2299:
2297:
2296:
2290:
2288:
2278:
2277:
2275:
2274:
2269:
2268:
2267:
2262:
2251:
2249:
2235:
2234:
2223:
2221:
2220:
2213:
2206:
2198:
2189:
2188:
2185:
2184:
2182:
2181:
2175:
2173:
2167:
2166:
2164:
2163:
2157:
2155:
2148:
2147:
2144:
2143:
2141:
2140:
2134:
2132:
2128:
2127:
2125:
2124:
2118:
2116:
2110:
2109:
2107:
2106:
2101:
2095:
2093:
2087:
2086:
2084:
2083:
2077:
2076:
2071:
2066:
2056:
2055:
2050:
2044:
2039:
2034:
2029:
2019:
2017:
2010:
2008:Beta oxidation
2004:
2003:
2001:
2000:
1995:
1990:
1984:
1982:
1980:Acyl transport
1973:
1967:
1966:
1963:
1962:
1960:
1959:
1954:
1948:
1946:
1942:
1941:
1939:
1938:
1932:
1930:
1923:
1922:
1920:
1919:
1914:
1909:
1904:
1898:
1896:
1885:
1884:
1882:
1881:
1876:
1870:
1868:
1858:
1854:
1853:
1829:
1827:
1826:
1819:
1812:
1804:
1795:
1794:
1792:
1791:
1785:
1784:
1779:
1774:
1769:
1764:
1759:
1754:
1749:
1743:
1741:
1737:
1736:
1734:
1733:
1728:
1723:
1718:
1712:
1710:
1706:
1705:
1703:
1702:
1696:
1694:
1686:
1685:
1683:
1682:
1681:
1680:
1675:
1667:
1662:
1661:
1660:
1655:
1650:
1641:
1639:
1635:
1634:
1624:
1622:
1621:
1614:
1607:
1599:
1593:
1592:
1580:
1577:
1575:
1574:
1523:
1484:
1449:
1414:
1357:
1339:
1321:
1300:
1278:
1276:
1273:
1248:
1245:
1212:
1209:
1193:
1190:
1161:
1160:
1157:
1156:
1151:
1141:
1140:
1134:
1133:
1130:
1129:
1127:
1125:
1118:
1117:
1110:
1103:
1099:
1098:
1095:
1094:
1076:
1075:
1069:
1066:
1065:
1047:
1046:
1020:
1016:
1015:
1012:
1011:
993:
992:
986:
983:
982:
964:
963:
937:
933:
932:
929:
928:
920:
919:
913:
910:
909:
901:
900:
894:
888:
887:
884:
883:
875:
874:
868:
865:
864:
856:
855:
849:
843:
842:
839:
838:
830:
829:
823:
820:
819:
811:
810:
804:
798:
797:
792:
787:
783:
782:
772:
771:
768:
767:
756:
755:
753:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
691:
689:
685:
684:
682:
681:
676:
671:
666:
661:
656:
651:
646:
640:
638:
634:
633:
631:
630:
625:
620:
615:
610:
605:
600:
595:
590:
585:
579:
577:
573:
572:
562:
561:
558:
557:
554:
553:
550:
549:
542:
536:
535:
532:
531:
523:
522:
519:
518:
516:
515:
511:
507:
503:
499:
498:lacrimal gland
495:
491:
487:
483:
479:
475:
472:
471:
460:
457:
456:
454:
453:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
410:
409:
397:
396:
388:
377:
371:
370:
367:RNA expression
359:
358:
355:
354:
346:
342:
341:
333:
330:
325:
319:
318:
309:
302:
296:
292:
291:
286:
280:
279:
271:
270:
258:
257:
254:
253:
245:
241:
240:
232:
229:
224:
218:
217:
208:
201:
195:
191:
190:
183:
177:
176:
168:
167:
155:
154:
111:
107:
106:
98:
90:
89:
85:
84:
81:
80:
77:
76:
66:
65:
57:
56:
45:
39:
38:
30:
29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
2808:
2797:
2794:
2792:
2789:
2787:
2784:
2783:
2781:
2770:
2765:
2763:
2758:
2756:
2751:
2750:
2744:
2742:
2738:
2735:article is a
2734:
2729:
2726:
2722:
2717:
2711:
2706:
2701:
2697:
2683:
2679:
2678:
2673:
2670:
2666:
2665:
2660:
2657:
2653:
2652:
2647:
2644:
2640:
2639:
2634:
2631:
2627:
2626:
2621:
2618:
2614:
2613:
2608:
2605:
2601:
2600:
2595:
2594:
2592:
2588:
2582:
2579:
2577:
2574:
2572:
2569:
2567:
2564:
2562:
2559:
2558:
2556:
2552:
2546:
2543:
2541:
2540:Enzyme family
2538:
2536:
2533:
2531:
2528:
2527:
2525:
2521:
2515:
2512:
2510:
2507:
2505:
2504:Cooperativity
2502:
2500:
2497:
2496:
2494:
2490:
2484:
2481:
2479:
2476:
2474:
2471:
2469:
2466:
2464:
2463:Oxyanion hole
2461:
2459:
2456:
2454:
2451:
2449:
2446:
2445:
2443:
2439:
2435:
2428:
2423:
2421:
2416:
2414:
2409:
2408:
2405:
2393:
2390:
2389:
2387:
2385:
2381:
2377:
2369:
2366:
2364:
2361:
2359:
2356:
2354:
2351:
2350:
2349:
2346:
2344:
2341:
2339:
2336:
2335:
2333:
2331:
2327:
2323:
2317:
2314:
2313:
2311:
2309:
2305:
2301:
2295:
2292:
2291:
2289:
2287:
2283:
2279:
2273:
2270:
2266:
2263:
2261:
2258:
2257:
2256:
2253:
2252:
2250:
2248:
2244:
2240:
2236:
2231:
2227:
2224:Aldehyde/oxo
2219:
2214:
2212:
2207:
2205:
2200:
2199:
2196:
2180:
2177:
2176:
2174:
2172:
2168:
2162:
2159:
2158:
2156:
2154:
2149:
2139:
2136:
2135:
2133:
2129:
2123:
2120:
2119:
2117:
2115:
2111:
2105:
2102:
2100:
2097:
2096:
2094:
2092:
2088:
2082:
2079:
2078:
2075:
2072:
2070:
2067:
2065:
2061:
2058:
2057:
2054:
2051:
2048:
2045:
2043:
2040:
2038:
2035:
2033:
2030:
2028:
2024:
2021:
2020:
2018:
2014:
2011:
2009:
2005:
1999:
1996:
1994:
1991:
1989:
1986:
1985:
1983:
1981:
1977:
1974:
1972:
1968:
1958:
1955:
1953:
1950:
1949:
1947:
1943:
1937:
1934:
1933:
1931:
1929:
1924:
1918:
1915:
1913:
1910:
1908:
1905:
1903:
1900:
1899:
1897:
1895:
1890:
1886:
1880:
1877:
1875:
1872:
1871:
1869:
1866:
1862:
1859:
1855:
1851:
1848:
1844:
1840:
1836:
1832:
1825:
1820:
1818:
1813:
1811:
1806:
1805:
1802:
1790:
1787:
1786:
1783:
1780:
1778:
1775:
1773:
1770:
1768:
1765:
1763:
1760:
1758:
1755:
1753:
1750:
1748:
1745:
1744:
1742:
1738:
1732:
1729:
1727:
1724:
1722:
1719:
1717:
1714:
1713:
1711:
1707:
1701:
1698:
1697:
1695:
1692:
1691:mitochondrial
1687:
1679:
1676:
1674:
1671:
1670:
1668:
1666:
1663:
1659:
1656:
1654:
1651:
1649:
1646:
1645:
1643:
1642:
1640:
1636:
1631:
1627:
1620:
1615:
1613:
1608:
1606:
1601:
1600:
1597:
1590:
1586:
1583:
1582:
1578:
1570:
1566:
1561:
1556:
1551:
1546:
1543:(4): 461–71.
1542:
1538:
1534:
1527:
1524:
1519:
1515:
1511:
1507:
1504:(2): 127–35.
1503:
1499:
1495:
1488:
1485:
1480:
1476:
1472:
1468:
1464:
1460:
1453:
1450:
1445:
1441:
1437:
1433:
1429:
1425:
1418:
1415:
1410:
1406:
1401:
1396:
1392:
1388:
1384:
1380:
1376:
1372:
1368:
1361:
1358:
1353:
1349:
1343:
1340:
1335:
1331:
1325:
1322:
1318:
1314:
1309:
1307:
1305:
1301:
1297:
1293:
1288:
1286:
1284:
1280:
1274:
1272:
1270:
1269:glycerolipids
1266:
1262:
1258:
1254:
1246:
1244:
1242:
1239:At least two
1237:
1235:
1231:
1227:
1223:
1219:
1210:
1208:
1206:
1202:
1199:
1191:
1189:
1187:
1183:
1179:
1175:
1171:
1167:
1155:
1150:
1146:
1142:
1139:
1135:
1128:
1126:
1123:
1119:
1115:
1111:
1108:
1104:
1100:
1093:
1091:
1087:
1083:
1077:
1073:
1070:
1064:
1062:
1058:
1054:
1048:
1044:
1040:
1036:
1032:
1028:
1024:
1021:
1017:
1010:
1008:
1004:
1000:
994:
990:
987:
981:
979:
975:
971:
965:
961:
957:
953:
949:
945:
941:
938:
936:RefSeq (mRNA)
934:
927:
926:
921:
917:
914:
908:
907:
902:
898:
895:
893:
889:
882:
881:
876:
872:
869:
863:
862:
857:
853:
850:
848:
844:
837:
836:
831:
827:
824:
818:
817:
812:
808:
805:
803:
799:
796:
793:
791:
788:
784:
781:
777:
773:
766:
762:
757:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
692:
690:
687:
686:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
641:
639:
636:
635:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
599:
596:
594:
591:
589:
586:
584:
581:
580:
578:
575:
574:
571:
570:Gene ontology
567:
563:
551:
546:
543:
541:
537:
529:
524:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
476:
473:
469:
464:
461:
451:
447:
444:kidney tubule
443:
440:hair follicle
439:
435:
431:
428:skin of thigh
427:
423:
419:
415:
414:
411:
407:
402:
399:
398:
395:
393:
389:
387:
386:
382:
381:
378:
376:
372:
368:
364:
360:
352:
347:
343:
339:
334:
324:
320:
313:
306:
300:
293:
285:
281:
277:
272:
268:
263:
259:
251:
246:
242:
238:
233:
223:
219:
212:
205:
199:
192:
188:
182:
178:
174:
169:
165:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
108:
103:
96:
91:
86:
75:
73:
67:
62:
59:
58:
54:
51:
44:
40:
35:
31:
27:
22:
19:
2741:expanding it
2730:
2715:
2677:Translocases
2674:
2661:
2648:
2635:
2622:
2612:Transferases
2609:
2596:
2453:Binding site
2264:
2178:
1843:triglyceride
1720:
1540:
1536:
1526:
1501:
1497:
1487:
1462:
1458:
1452:
1427:
1423:
1417:
1374:
1370:
1360:
1351:
1342:
1333:
1324:
1252:
1250:
1238:
1214:
1195:
1177:
1169:
1165:
1164:
1086:NP_001318044
1082:NP_001318043
1079:
1061:NP_001356077
1057:NP_001356075
1053:NP_001356068
1050:
1043:NP_001356067
1039:NP_001356066
1035:NP_001356065
1031:NP_001026976
1007:NM_001331115
1003:NM_001331114
996:
978:NM_001369148
974:NM_001369146
970:NM_001369139
967:
960:NM_001369138
956:NM_001369137
952:NM_001369136
948:NM_001031806
923:
904:
878:
859:
833:
814:
794:
789:
478:right kidney
390:
383:
110:External IDs
69:
18:
2448:Active site
2091:Unsaturated
1971:Degradation
1928:desaturases
1926:Fatty acid
1865:Malonyl-CoA
1201:superfamily
514:gallbladder
490:granulocyte
452:skin of arm
432:skin of hip
349:61,158,290
336:61,114,243
248:19,685,760
235:19,648,136
88:Identifiers
2780:Categories
2651:Isomerases
2625:Hydrolases
2492:Regulation
2286:cytochrome
2153:acetyl-CoA
1957:Thiokinase
1847:fatty acid
1831:Metabolism
1689:Family 2 (
1560:2115/49428
1371:Nat Commun
1319:, May 2017
1298:, May 2017
1275:References
730:metabolism
664:peroxisome
394:(ortholog)
131:HomoloGene
2530:EC number
2330:disulfide
2171:Aldehydes
2114:Odd chain
1867:synthesis
1857:Synthesis
1537:Mol. Cell
1234:microsome
1222:co-factor
1192:Structure
1186:aldehydes
1090:NP_031463
1027:NP_000373
999:NM_007437
944:NM_000382
780:Orthologs
139:GeneCards
2791:EC 1.2.1
2554:Kinetics
2478:Cofactor
2441:Activity
1782:ALDH18A1
1777:ALDH16A1
1709:Family 3
1638:Family 1
1569:22633490
1498:Genomics
1409:25047030
1377:: 4439.
1315:–
1294:–
1211:Function
1172:) is an
1138:Wikidata
759:Sources:
654:membrane
510:yolk sac
506:duodenum
486:gastrula
2710:Biology
2664:Ligases
2434:Enzymes
2016:General
1850:enzymes
1772:ALDH9A1
1767:ALDH8A1
1757:ALDH6A1
1752:ALDH5A1
1747:ALDH4A1
1731:ALDH3B2
1726:ALDH3B1
1678:ALDH1L2
1673:ALDH1L1
1665:ALDH1B1
1658:ALDH1A3
1653:ALDH1A2
1648:ALDH1A1
1518:9027499
1479:9133646
1444:9133646
1400:4109017
1379:Bibcode
1317:Ensembl
1296:Ensembl
1253:ALDH3A2
1178:ALDH3A2
892:UniProt
847:Ensembl
786:Species
765:QuickGO
502:decidua
369:pattern
227:17p11.2
143:ALDH3A2
127:1353452
102:ALDH3A2
95:Aliases
24:ALDH3A2
2696:Portal
2638:Lyases
2358:BCKDHB
2353:BCKDHA
2308:oxygen
2047:ACADSB
2042:ACADVL
1632:1.2.1)
1591:(MeSH)
1567:
1516:
1477:
1442:
1407:
1397:
1124:search
1122:PubMed
925:P47740
906:P51648
802:Entrez
540:BioGPS
448:nipple
119:609523
2731:This
2590:Types
2380:1.2.7
2326:1.2.4
2304:1.2.3
2282:1.2.2
2239:1.2.1
2131:Other
2074:HADHB
2069:HADHA
2037:ACADS
2032:ACADM
2027:ACADL
1740:Other
1700:ALDH2
1259:, an
1230:liver
1220:as a
1205:dimer
835:11671
795:Mouse
790:Human
761:Amigo
392:Mouse
385:Human
332:Start
267:Mouse
231:Start
164:Human
135:55458
2737:stub
2682:list
2675:EC7
2669:list
2662:EC6
2656:list
2649:EC5
2643:list
2636:EC4
2630:list
2623:EC3
2617:list
2610:EC2
2604:list
2597:EC1
2247:NADP
2232:1.2)
2064:HADH
1845:and
1565:PMID
1514:PMID
1475:PMID
1463:1335
1440:PMID
1428:1335
1405:PMID
1265:mRNA
1218:NAD+
1168:(or
375:Bgee
323:Band
284:Chr.
222:Band
181:Chr.
115:OMIM
72:4QGK
53:RCSB
50:PDBe
2368:DLD
2363:DBT
2245:or
2243:NAD
2151:To
2060:MTP
1555:hdl
1545:doi
1506:doi
1467:doi
1432:doi
1395:PMC
1387:doi
816:224
548:n/a
345:End
244:End
147:OMA
123:MGI
43:PDB
2782::
2382::
2328::
2306::
2284::
2241::
2230:EC
2062::
1841:,
1837:/
1833::
1630:EC
1563:.
1553:.
1541:46
1539:.
1535:.
1512:.
1502:39
1500:.
1496:.
1473:.
1461:.
1438:.
1426:.
1403:.
1393:.
1385:.
1373:.
1369:.
1350:.
1332:.
1303:^
1282:^
763:/
351:bp
338:bp
250:bp
237:bp
145:;
141::
137:;
133::
129:;
125::
121:;
117::
2768:e
2761:t
2754:v
2743:.
2698::
2684:)
2680:(
2671:)
2667:(
2658:)
2654:(
2645:)
2641:(
2632:)
2628:(
2619:)
2615:(
2606:)
2602:(
2426:e
2419:t
2412:v
2228:(
2217:e
2210:t
2203:v
2049:)
2025:(
1891:/
1823:e
1816:t
1809:v
1693:)
1628:(
1618:e
1611:t
1604:v
1571:.
1557::
1547::
1520:.
1508::
1481:.
1469::
1446:.
1434::
1411:.
1389::
1381::
1375:5
1354:.
1336:.
269:)
166:)
149::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
