201:, has been confirmed to being derived from the misclassified MDA-MB-435 cell line. So it is also misclassified, really being a melanoma cell line, but as of 6 January 2018 the official website still lists it as breast cancer cell line. This cell line is not available as of 6 January 2018.
77:
Due to the diversity of the cell lines, it is possible to compare tested compounds by their effect patterns, high correlation potentially corresponding to similar effect mechanisms. An automated comparison against a database of more than 88,000 pure compounds and more than 34,000 crude extracts (as
220:
As of 2014 Hundreds of research studies still use MDA-MB-435 as model of breast cancer, even after it was officially declared to be a melanoma cell line in 2007, and even in highest-rated international peer-reviewed journals. Similar is true for other misidentified cell lines.
212:. It includes the cell lines reported above, although usually with reporting dates and articles considerably later than the first dates and articles rising specific concern regarding the respective cell line.
165:, originally classified as breast cancer cell line, was identified as being a melanoma cell line. When investigated further, current MDA-MB-435 appeared to be derived from the same individual as cell line
238:(RRID) have been added. The Cellosaurus identifier is a combination of the cell line name variant chosen by Cellosaurus, with the Cellosaurus accession ID, the latter written as RRID.
175:, originally classified as breast cancer cell line, was identified as being an ovarian tumor cell line. NCI/ADR-RES appears to have been derived at some point in time from cell line
169:. An examination of clones made clear that the mixup with M14 happened very early in the history of MDA-MB-435, before establishment in the Developmental Therapeutics Program.
1858:
Additional cell lines evaluated for use in NCI's Tumor Cell Lines Screen as described on the website of the
Developmental Therapeutics Program. Links to corresponding
230:
The NCI-60 cell lines used by NCI's Human Tumor Cell Lines Screen as described on the website of the
Developmental Therapeutics Program. Links to corresponding
159:
Starting around the turn of the millennium, several cell lines were found to be misidentified or misclassified at the time of investigation or earlier:
55:
59:
2506:
2467:
2430:
2389:
2350:
2318:
2287:
2255:
2223:
2184:
205:
63:
2626:
2594:
144:
13 additional cell lines are evaluated for use in the screening program, among them two lines deriving from so far not represented
151:
All cell lines but one (as of 6 January 2017) are available to other laboratories, including the additional cell lines.
209:
83:
93:
for the characterization of molecular targets. Measurements include protein levels, RNA measurements, mutation status and
1863:
235:
114:
2584:
1891:
430:
2658:
2472:
2435:
2394:
2323:
2292:
2260:
2228:
2189:
145:
43:
90:
2663:
2532:"Continued use of MDA-MB-435, a melanoma cell line, as a model for human breast cancer, even in year, 2014"
1912:
2638:
The reference includes the pages found by searching with the respective cell line names as given in the
2462:
2345:
2425:
2384:
2497:
2179:
2218:
2563:
2536:
1952:
657:
130:
2385:"MDA-MB-435, and its derivation MDA-N, are Melanoma cell lines, not breast cancer cell lines"
79:
2553:
2545:
2250:
1608:
166:
138:
94:
2558:
2531:
1223:
122:
2652:
2313:
2072:
1664:
1404:
180:
134:
126:
706:
2621:
2589:
1992:
1859:
838:
231:
172:
118:
855:
2549:
1715:
1688:
323:
162:
67:
46:(NCI) for the screening of compounds to detect potential anticancer activity.
425:
71:
35:
2567:
194:, were discovered to come from the same person. This makes a mixup likely.
2112:
2032:
994:
272:
110:
106:
2426:"Cell Line NCI/ADR-RES is an Ovarian tumor cell line, not a Breast line"
2142:
2123:
2102:
2083:
2062:
2043:
2022:
2003:
1982:
1963:
1942:
1923:
1902:
1844:
1817:
1790:
1762:
1735:
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1471:
1446:
1421:
1394:
1367:
1340:
1315:
1290:
1265:
1240:
1213:
1188:
1163:
1138:
1113:
1088:
1061:
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1011:
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957:
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547:
522:
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447:
418:
393:
368:
343:
316:
289:
2585:"Cellosaurus search result: 61 hits for "NCI60 cancer cell line panel""
1742:
1374:
176:
2606:
The reference includes the list of linked pages in the search result.
2463:"CNS cell lines SNB-19 and U251 are derived from the same individual"
1797:
1632:
187:
39:
17:
1824:
758:
198:
1659:
1603:
296:
191:
2616:
183:; it was renamed together with the change in classification.
2530:
Prasad, Vidudala VTS; Gopalan, Ramprasad OG (2 June 2015).
2499:
2282:
82:
tool, which shows a list of substances ranked by the
2492:
2490:
2283:"Welcome to the Developmental Therapeutics Program"
2639:
2617:"Cellosaurus - a knowledge resource on cell lines"
66:(DTP). The screening rates for each cell line the
2525:
2523:
2507:International Cell Line Authentication Committee
1866:(RRID) have been added, as well as the species.
206:International Cell Line Authentication Committee
78:of 6 January 2017) is provided by the
2579:
2577:
2457:
2455:
2453:
8:
2420:
2418:
2416:
2414:
2412:
2379:
2377:
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2369:
2174:
2172:
2170:
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2166:
2164:
2162:
2160:
1856:
228:
2557:
2354:. National Cancer Institute. 12 May 2015
2213:
2211:
2209:
2207:
105:The panel holds cell lines representing
2156:
155:Misidentification and Misclassification
2251:"Discovery & Development Services"
2219:"NCI-60 Human Tumor Cell Lines Screen"
1347:NCI/ADR-RES (originally MCF-7/ADR-RES)
54:The screening procedure is called the
216:Continued Use of Wrong Classification
179:. Originally the cell line was named
7:
60:Discovery & Development Services
56:NCI-60 Human Tumor Cell Lines Screen
2180:"Cell Lines in the In Vitro Screen"
2468:Developmental Therapeutics Program
2431:Developmental Therapeutics Program
2390:Developmental Therapeutics Program
2351:Developmental Therapeutics Program
2319:Developmental Therapeutics Program
2288:Developmental Therapeutics Program
2256:Developmental Therapeutics Program
2224:Developmental Therapeutics Program
2185:Developmental Therapeutics Program
64:Developmental Therapeutics Program
25:
2627:Swiss Institute of Bioinformatics
2595:Swiss Institute of Bioinformatics
1883:Cellosaurus identifier and link
264:Cellosaurus identifier and link
84:Pearson correlation coefficients
210:list of contaminated cell lines
89:The same panel is used in the
1:
2640:List of Additional Cell Lines
1864:Research Resource Identifiers
1853:List of Additional Cell Lines
236:Research Resource Identifiers
186:Two brain cancer cell lines,
115:non-small-cell lung carcinoma
74:impact of tested substances.
38:panel is a group of 60 human
1368:NCI-ADR-RES (RRID:CVCL_1452)
86:for a given test substance.
1736:MDA-MB-468 (RRID:CVCL_0419)
1709:MDA-MB-231 (RRID:CVCL_0062)
1089:MDA-MB-435 (RRID:CVCL_0417)
249:(Potentially) misidentified
2680:
2044:RPMI-7951 (RRID:CVCL_1666)
1903:LXFL 529L (RRID:CVCL_D085)
1139:SK-MEL-28 (RRID:CVCL_0526)
598:NCI-H322M (RRID:CVCL_1557)
394:RPMI-8226 (RRID:CVCL_0014)
317:HL-60(TB) (RRID:CVCL_A794)
2550:10.1038/npjbcancer.2015.2
2473:National Cancer Institute
2436:National Cancer Institute
2395:National Cancer Institute
2324:National Cancer Institute
2293:National Cancer Institute
2261:National Cancer Institute
2229:National Cancer Institute
2190:National Cancer Institute
2143:P388/ADR (RRID:CVCL_IZ75)
2084:RXF 631L (RRID:CVCL_A780)
1522:RXF 393L (RRID:CVCL_1673)
1189:UACC-257 (RRID:CVCL_1779)
1164:SK-MEL-5 (RRID:CVCL_0527)
1114:SK-MEL-2 (RRID:CVCL_0069)
1037:Malme-3M (RRID:CVCL_1438)
1012:LOX-IMVI (RRID:CVCL_1381)
675:COLO 205 (RRID:CVCL_0218)
648:NCI-H522 (RRID:CVCL_1567)
623:NCI-H460 (RRID:CVCL_0459)
548:NCI-H226 (RRID:CVCL_1544)
290:CCRF-CEM (RRID:CVCL_0207)
225:List of NCI-60 Cell Lines
146:small-cell lung carcinoma
44:National Cancer Institute
2509:(ICLAC), 1 December 2016
2063:M19-MEL (RRID:CVCL_B415)
1924:DMS 114 (RRID:CVCL_1174)
1763:Hs 578T (RRID:CVCL_0332)
1395:SK-OV-3 (RRID:CVCL_0532)
1341:OVCAR-8 (RRID:CVCL_1629)
1316:OVCAR-5 (RRID:CVCL_1628)
1291:OVCAR-4 (RRID:CVCL_1627)
1266:OVCAR-3 (RRID:CVCL_0465)
1241:IGROV-1 (RRID:CVCL_1304)
1214:UACC-62 (RRID:CVCL_1780)
985:U-251MG (RRID:CVCL_0021)
727:HCT 116 (RRID:CVCL_0291)
700:HCC2998 (RRID:CVCL_1266)
573:NCI-H23 (RRID:CVCL_1547)
91:Molecular Target Program
2103:SN12K1 (RRID:CVCL_D106)
2023:XF 498 (RRID:CVCL_8928)
2004:SNB-78 (RRID:CVCL_B321)
1983:KM20L2 (RRID:CVCL_D889)
1943:SHP-77 (RRID:CVCL_1693)
1818:BT-549 (RRID:CVCL_1092)
1497:Caki-1 (RRID:CVCL_0234)
958:SNB-75 (RRID:CVCL_1706)
933:SNB-19 (RRID:CVCL_0535)
752:HCT 15 (RRID:CVCL_0292)
523:HOP-92 (RRID:CVCL_1286)
498:HOP-62 (RRID:CVCL_1285)
369:MOLT-4 (RRID:CVCL_0013)
252:Original classification
58:, and it is one of the
42:cell lines used by the
1964:DLD-1 (RRID:CVCL_0248)
1845:T-47D (RRID:CVCL_0553)
1791:MDA-N (RRID:CVCL_1910)
1682:MCF-7 (RRID:CVCL_0031)
1653:DU145 (RRID:CVCL_0105)
1597:UO-31 (RRID:CVCL_1911)
1572:TK-10 (RRID:CVCL_1773)
1547:SN12C (RRID:CVCL_1705)
1447:A-498 (RRID:CVCL_1056)
1422:786-O (RRID:CVCL_1051)
906:SF539 (RRID:CVCL_1691)
881:SF295 (RRID:CVCL_1690)
856:SF268 (RRID:CVCL_1689)
829:SW620 (RRID:CVCL_0547)
779:HT-29 (RRID:CVCL_0320)
448:A-549 (RRID:CVCL_0023)
344:K-562 (RRID:CVCL_0004)
27:Cancer cell line panel
2124:P388 (RRID:CVCL_7222)
1626:PC-3 (RRID:CVCL_0035)
1472:ACHN (RRID:CVCL_1067)
804:KM12 (RRID:CVCL_1331)
473:EKVX (RRID:CVCL_1195)
258:Doubling Time (Hours)
117:, and cancers of the
1874:Tumor classification
1062:M14 (RRID:CVCL_1395)
246:Tumor classification
2346:"Molecular Targets"
1892:Non-Small Cell Lung
1880:Inoculation Density
1867:
632:Non-Small Cell Lung
607:Non-Small Cell Lung
582:Non-Small Cell Lung
557:Non-Small Cell Lung
532:Non-Small Cell Lung
507:Non-Small Cell Lung
482:Non-Small Cell Lung
457:Non-Small Cell Lung
431:Non-Small Cell Lung
419:SR (RRID:CVCL_1711)
261:Inoculation Density
239:
2314:"COMPARE Analysis"
1857:
229:
197:A 61st cell line,
2537:npj Breast Cancer
2148:
2147:
1862:descriptions and
1850:
1849:
234:descriptions and
16:(Redirected from
2671:
2659:Human cell lines
2643:
2637:
2635:
2633:
2613:
2607:
2605:
2603:
2601:
2581:
2572:
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2326:. 11 August 2015
2310:
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2263:. 26 August 2015
2247:
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2231:. 26 August 2015
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1933:Small Cell Lung
1913:Small Cell Lung
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103:
95:enzyme activity
52:
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2664:Ovarian cancer
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189:
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181:MCF-7/ADR-RES
178:
174:
170:
168:
164:
160:
154:
152:
149:
147:
142:
140:
136:
132:
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37:
33:
19:
2630:. Retrieved
2620:
2611:
2598:. Retrieved
2588:
2541:
2535:
2511:, retrieved
2498:
2477:. Retrieved
2475:. 8 May 2015
2466:
2440:. Retrieved
2438:. 8 May 2015
2429:
2399:. Retrieved
2397:. 8 May 2015
2388:
2356:. Retrieved
2349:
2340:
2328:. Retrieved
2317:
2308:
2296:. Retrieved
2286:
2277:
2265:. Retrieved
2254:
2245:
2233:. Retrieved
2222:
2194:. Retrieved
2192:. 8 May 2015
2183:
219:
208:maintains a
203:
196:
185:
171:
161:
158:
150:
143:
104:
88:
76:
53:
31:
29:
2622:Cellosaurus
2590:Cellosaurus
1860:Cellosaurus
1781:unavailable
255:Unavailable
232:Cellosaurus
173:NCI/ADR-RES
2653:Categories
2632:17 January
2544:: 15002–.
2151:References
1716:MDA-MB-468
1689:MDA-MB-231
1068:MDA-MB-435
163:MDA-MB-435
101:Cell Lines
68:cytostatic
2600:7 January
2513:6 January
2479:6 January
2442:6 January
2401:6 January
2358:7 January
2330:6 January
2298:6 January
2267:6 January
2235:6 January
2196:6 January
2029:RPMI-7951
1871:Cell line
1120:SK-MEL-28
579:NCI-H322M
375:RPMI-8226
297:HL-60(TB)
243:Cell line
72:cytotoxic
62:of NCI's
36:cell line
2568:28721362
2133:Leukemia
2130:P388/ADR
2113:Leukemia
2053:Melanoma
2033:Melanoma
1888:LXFL 529
1772:Melanoma
1637:Prostate
1609:Prostate
1198:Melanoma
1173:Melanoma
1170:UACC-257
1148:Melanoma
1145:SK-MEL-5
1123:Melanoma
1098:Melanoma
1095:SK-MEL-2
1071:Melanoma
1046:Melanoma
1021:Melanoma
1018:MALME-3M
995:Melanoma
991:LOX IMVI
681:HCC-2998
654:COLO 205
629:NCI-H522
604:NCI-H460
529:NCI-H226
403:Leukemia
378:Leukemia
353:Leukemia
328:Leukemia
301:Leukemia
273:Leukemia
269:CCRF-CEM
139:prostate
111:melanoma
107:leukemia
97:levels.
2559:5515196
2505:, 8.0,
2069:RXF-631
2050:M19-MEL
1909:DMS 114
1877:Species
1747:Breast
1743:HS 578T
1720:Breast
1503:RXF 393
1379:Ovarian
1375:SK-OV-3
1350:Ovarian
1325:Ovarian
1322:OVCAR-8
1300:Ovarian
1297:OVCAR-5
1275:Ovarian
1272:OVCAR-4
1250:Ovarian
1247:OVCAR-3
1224:Ovarian
1220:IGROV-1
1195:UACC-62
554:NCI-H23
177:OVCAR-8
80:COMPARE
50:Purpose
34:cancer
2566:
2556:
2090:SN12K1
2010:XF 498
1989:SNB-78
1970:KM20L2
1930:SHP-77
1829:Breast
1802:Breast
1798:BT-549
1778:Breast
1759:20000
1693:Breast
1665:Breast
1633:DU-145
1478:CAKI-1
1356:Breast
1077:Breast
939:SNB-75
912:SNB-19
887:SF-539
862:SF-295
835:SF-268
810:SW-620
733:HCT-15
707:HCT116
504:HOP-92
479:HOP-62
400:SR-786
350:MOLT-4
188:SNB-19
137:, and
135:kidney
127:breast
40:cancer
32:NCI-60
2503:(PDF)
2139:50000
2136:mouse
2120:50000
2117:mouse
2099:10000
2096:human
2093:Renal
2080:10000
2077:human
2073:Renal
2059:10000
2056:human
2040:20000
2037:human
2019:20000
2016:human
2000:20000
1997:human
1979:10000
1976:human
1973:Colon
1960:50000
1957:human
1953:Colon
1949:DLD-1
1939:40000
1936:human
1920:20000
1917:human
1899:10000
1896:human
1841:20000
1825:T-47D
1814:20000
1787:15000
1769:MDA-N
1756:53.8
1732:2000
1705:20000
1678:10000
1649:10000
1593:15000
1581:Renal
1578:UO-31
1568:15000
1556:Renal
1553:TK-10
1543:15000
1531:Renal
1528:SN12C
1518:15000
1506:Renal
1493:10000
1481:Renal
1468:10000
1456:Renal
1443:25000
1431:Renal
1418:10000
1405:Renal
1401:786-O
1391:20000
1364:15000
1337:10000
1312:20000
1287:15000
1262:10000
1237:10000
1210:10000
1185:20000
1160:10000
1135:10000
1110:20000
1085:15000
1058:15000
1033:20000
954:20000
929:15000
902:15000
877:10000
852:15000
825:10000
813:Colon
800:15000
788:Colon
763:Colon
759:HT-29
748:10000
736:Colon
711:Colon
696:15000
684:Colon
671:15000
658:Colon
644:20000
594:20000
569:20000
544:20000
519:20000
494:10000
469:20000
415:20000
390:20000
365:30000
324:K-562
313:40000
286:40000
199:MDA-N
131:colon
123:ovary
119:brain
2634:2018
2602:2018
2564:PMID
2515:2018
2481:2018
2444:2018
2403:2018
2360:2018
2332:2018
2300:2018
2269:2018
2237:2018
2198:2018
2109:P388
1838:45.5
1811:53.9
1784:22.5
1702:41.9
1675:25.4
1660:MCF7
1646:32.3
1622:7500
1619:27.1
1604:PC-3
1590:41.7
1565:51.3
1540:29.5
1515:62.9
1465:27.5
1453:ACHN
1440:66.8
1428:A498
1415:22.4
1388:48.7
1334:26.1
1309:48.8
1284:41.4
1259:34.7
1207:31.3
1182:38.5
1157:25.2
1132:35.1
1107:45.5
1082:25.8
1055:26.3
1030:46.2
1008:7500
1005:20.5
981:7500
978:23.8
964:U251
951:62.8
926:34.6
899:35.4
874:29.5
849:33.1
822:20.4
797:23.7
785:KM12
775:5000
772:19.5
745:20.6
723:5000
720:17.4
693:31.5
668:23.8
641:38.2
619:7500
616:17.8
591:35.3
566:33.4
516:79.5
466:43.6
454:EKVX
444:7500
441:22.9
426:A549
412:28.7
387:33.5
362:27.9
340:5000
337:19.6
310:28.6
283:26.7
204:The
192:U251
190:and
70:and
30:The
18:P388
2554:PMC
2546:doi
2013:CNS
1993:CNS
1775:yes
1729:62
1353:yes
1074:yes
1043:M14
973:CNS
970:yes
967:CNS
942:CNS
921:CNS
918:yes
915:CNS
890:CNS
865:CNS
839:CNS
167:M14
2655::
2625:.
2619:.
2593:.
2587:.
2576:^
2562:.
2552:.
2540:.
2534:.
2522:^
2489:^
2471:.
2465:.
2452:^
2434:.
2428:.
2411:^
2393:.
2387:.
2368:^
2348:.
2322:.
2316:.
2291:.
2285:.
2259:.
2253:.
2227:.
2221:.
2206:^
2188:.
2182:.
2159:^
1490:39
1361:34
1234:31
541:61
491:39
148:.
141:.
133:,
129:,
125:,
121:,
113:,
109:,
2642:.
2636:.
2604:.
2570:.
2548::
2542:1
2483:.
2446:.
2405:.
2362:.
2334:.
2302:.
2271:.
2239:.
2200:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.