253:
230:
127:
152:
259:
158:
1541:
970:. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain. The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of
1193:
Bruzzone F, Lectez B, Tollemer H, et al. (2007). "Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord".
1087:
Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003).
1230:
Chartrel N, Bruzzone F, Dujardin C, et al. (2006). "Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals".
266:
165:
1275:
Thuau R, Guilhaudis L, Ségalas-Milazzo I, et al. (2005). "Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity".
693:
674:
88:
1610:
1055:
1037:
1586:
1605:
893:
252:
900:
1073:
229:
1024:
1003:
1020:
151:
126:
999:
68:
1445:"Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155"
1089:"Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155"
265:
164:
1579:
1128:
Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003).
258:
157:
738:
76:
1357:"Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity"
1314:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
719:
1173:
1572:
1491:
1368:
1239:
140:
55:
1300:
1263:
1218:
100:
1480:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
876:
855:
829:
808:
17:
1519:
1466:
1431:
1396:
1343:
1292:
1255:
1210:
1151:
1110:
48:
1556:
1509:
1499:
1456:
1421:
1386:
1376:
1333:
1325:
1284:
1247:
1202:
1141:
1100:
345:
276:
220:
175:
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96:
1495:
1372:
1243:
1514:
1479:
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1313:
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1206:
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1222:
80:
1552:
1288:
338:
117:
104:
1060:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1042:
National Center for
Biotechnology Information, U.S. National Library of Medicine
971:
966:
The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of
421:
237:
134:
84:
1410:"A new peptidic ligand and its receptor regulating adrenal function in rats"
1381:
1251:
1130:"A new peptidic ligand and its receptor regulating adrenal function in rats"
638:
481:
359:
304:
291:
203:
190:
92:
1523:
1504:
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1444:
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1409:
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1347:
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1259:
1214:
1155:
1146:
1129:
1114:
1105:
1088:
940:
935:
924:
783:
764:
1329:
975:
960:
750:
705:
967:
908:
660:
1540:
1074:"Entrez Gene: P518 RF(Arg-Phe)amide family 26 amino acid peptide"
623:
619:
1548:
72:
1478:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
328:
1560:
1312:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
1355:
Chartrel N, Dujardin C, Anouar Y, et al. (2004).
493:
1408:
Fukusumi S, Yoshida H, Fujii R, et al. (2004).
869:
848:
822:
801:
1443:Jiang Y, Luo L, Gustafson EL, et al. (2003).
1016:
1014:
1012:
995:
993:
991:
275:
174:
59:, 26RFa, P518, pyroglutamylated RFamide peptide
27:Protein-coding gene in the species Homo sapiens
1021:GRCm38: Ensembl release 89: ENSMUSG00000043102
1580:
953:RF(Arg-Phe)amide family 26 amino acid peptide
537:orexigenic neuropeptide QRFP receptor binding
8:
609:G protein-coupled receptor signaling pathway
1000:GRCh38: Ensembl release 89: ENSG00000188710
974:, suggesting that QRFP and GPR103 regulate
1587:
1573:
634:
519:
316:
215:
112:
1513:
1503:
1460:
1425:
1390:
1380:
1337:
1145:
1104:
604:regulation of signaling receptor activity
987:
29:
584:positive regulation of blood pressure
280:
241:
236:
179:
138:
133:
7:
1537:
1535:
1559:. You can help Knowledge (XXG) by
866:
845:
819:
798:
774:
755:
729:
710:
684:
665:
498:
416:
354:
333:
25:
1539:
1207:10.1111/j.1471-4159.2006.04090.x
1178:IUPHAR/BPS Guide to PHARMACOLOGY
264:
257:
251:
228:
163:
156:
150:
125:
18:Pyroglutamylated RFamide peptide
1289:10.1016/j.peptides.2005.01.006
594:regulation of feeding behavior
589:neuropeptide signaling pathway
482:More reference expression data
1:
1611:Human chromosome 9 gene stubs
542:neuropeptide hormone activity
382:muscle layer of sigmoid colon
249:
148:
1484:Proc. Natl. Acad. Sci. U.S.A
1361:Proc. Natl. Acad. Sci. U.S.A
1606:Genes on human chromosome 9
386:stromal cell of endometrium
1627:
1534:
378:mucosa of transverse colon
1056:"Mouse PubMed Reference:"
1038:"Human PubMed Reference:"
939:
934:
930:
923:
907:
888:
873:
852:
841:
826:
805:
794:
781:
777:
762:
758:
749:
736:
732:
717:
713:
704:
691:
687:
672:
668:
659:
644:
637:
633:
617:
522:
518:
506:
501:
492:
479:
428:
419:
406:Descending thoracic aorta
366:
357:
327:
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315:
298:
285:
248:
227:
218:
214:
197:
184:
147:
124:
115:
111:
66:
63:
53:
46:
41:
37:
32:
894:Chr 9: 130.89 – 130.9 Mb
1382:10.1073/pnas.2434676100
1252:10.1196/annals.1327.009
1174:"Peptide P518 Receptor"
1505:10.1073/pnas.242603899
1462:10.1074/jbc.M302945200
1427:10.1074/jbc.M305270200
1147:10.1074/jbc.M305270200
1106:10.1074/jbc.M302945200
901:Chr 2: 31.7 – 31.7 Mb
1232:Ann. N. Y. Acad. Sci
558:extracellular region
440:white adipose tissue
402:left coronary artery
243:Chromosome 2 (mouse)
141:Chromosome 9 (human)
1496:2002PNAS...9916899M
1373:2003PNAS..10015247C
1244:2005NYASA1040...80C
599:locomotory behavior
436:islet of Langerhans
1547:This article on a
1330:10.1101/gr.2596504
739:ENSMUSG00000043102
572:Biological process
563:cellular component
551:Cellular component
530:Molecular function
1568:
1567:
1490:(26): 16899–903.
950:
949:
946:
945:
919:
918:
884:
883:
863:
862:
837:
836:
816:
815:
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789:
771:
770:
745:
744:
726:
725:
700:
699:
681:
680:
629:
628:
579:grooming behavior
514:
513:
510:
509:
488:
487:
475:
474:
413:
412:
311:
310:
210:
209:
16:(Redirected from
1618:
1589:
1582:
1575:
1543:
1536:
1527:
1517:
1507:
1474:
1464:
1439:
1429:
1420:(47): 46387–95.
1404:
1394:
1384:
1367:(25): 15247–52.
1351:
1341:
1308:
1271:
1226:
1181:
1160:
1159:
1149:
1140:(47): 46387–95.
1125:
1119:
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1108:
1084:
1078:
1077:
1070:
1064:
1063:
1052:
1046:
1045:
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1018:
1007:
997:
955:, also known as
932:
931:
903:
896:
879:
867:
858:
846:
842:RefSeq (protein)
832:
820:
811:
799:
775:
756:
730:
711:
685:
666:
635:
520:
499:
484:
424:
422:Top expressed in
417:
390:popliteal artery
362:
360:Top expressed in
355:
334:
317:
307:
294:
283:
268:
261:
255:
244:
232:
216:
206:
193:
182:
167:
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154:
143:
129:
113:
107:
105:QRFP - orthologs
58:
51:
30:
21:
1626:
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1621:
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1619:
1617:
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1615:
1596:
1595:
1594:
1593:
1532:
1530:
1477:
1455:(30): 27652–7.
1442:
1407:
1354:
1324:(10B): 2121–7.
1311:
1274:
1229:
1192:
1188:
1186:Further reading
1172:
1169:
1164:
1163:
1127:
1126:
1122:
1099:(30): 27652–7.
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1071:
1067:
1054:
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1031:
1019:
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989:
984:
941:View/Edit Mouse
936:View/Edit Human
899:
892:
889:Location (UCSC)
875:
854:
828:
807:
720:ENSG00000188710
613:
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546:
480:
471:
466:
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394:tibial arteries
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219:Gene location (
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116:Gene location (
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321:RNA expression
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1323:
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1315:
1310:
1306:
1302:
1298:
1294:
1290:
1286:
1283:(5): 779–89.
1282:
1278:
1273:
1269:
1265:
1261:
1257:
1253:
1249:
1245:
1241:
1237:
1233:
1228:
1224:
1220:
1216:
1212:
1208:
1204:
1201:(2): 616–27.
1200:
1196:
1191:
1190:
1185:
1179:
1175:
1171:
1170:
1166:
1157:
1153:
1148:
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1134:J. Biol. Chem
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1093:J. Biol. Chem
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1005:
1001:
996:
994:
992:
988:
981:
979:
977:
973:
969:
964:
962:
959:, is a human
958:
954:
942:
937:
933:
929:
926:
922:
915:
913:
910:
906:
902:
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895:
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878:
872:
868:
865:
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857:
851:
847:
844:
840:
833:
831:
825:
821:
818:
812:
810:
804:
800:
797:
795:RefSeq (mRNA)
793:
786:
785:
780:
776:
773:
767:
766:
761:
757:
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752:
748:
741:
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712:
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707:
703:
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677:
676:
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664:
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621:
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559:
556:
555:
553:
550:
549:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
497:
495:
491:
483:
478:
467:
463:
459:
455:
451:
448:adrenal gland
447:
443:
439:
435:
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430:
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418:
415:
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401:
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393:
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385:
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306:
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217:
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90:
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82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
1561:expanding it
1553:chromosome 9
1546:
1531:
1487:
1483:
1452:
1448:
1417:
1413:
1364:
1360:
1321:
1317:
1280:
1276:
1235:
1231:
1198:
1195:J. Neurochem
1194:
1177:
1137:
1133:
1123:
1096:
1092:
1082:
1068:
1059:
1050:
1041:
1032:
965:
956:
952:
951:
874:
853:
827:
806:
782:
763:
737:
718:
692:
673:
653:
648:
464:hypothalamus
444:spermatocyte
344:
337:
202:130,896,812
189:130,892,707
64:External IDs
1238:(1): 80–3.
972:aldosterone
398:sural nerve
303:31,700,592
290:31,696,178
42:Identifiers
1600:Categories
1318:Genome Res
1027:, May 2017
1006:, May 2017
982:References
978:function.
348:(ortholog)
282:2|2 B
85:HomoloGene
1551:on human
877:NP_906269
856:NP_937823
830:NM_183424
809:NM_198180
639:Orthologs
93:GeneCards
1524:12477932
1471:12714592
1436:12960173
1401:14657341
1348:15489334
1305:24088690
1297:15808908
1277:Peptides
1268:21012765
1260:15891009
1223:41427365
1215:16899066
1156:12960173
1115:12714592
1023:–
1002:–
925:Wikidata
618:Sources:
452:duodenum
370:testicle
1492:Bibcode
1369:Bibcode
1240:Bibcode
1025:Ensembl
1004:Ensembl
976:adrenal
961:protein
751:UniProt
706:Ensembl
645:Species
624:QuickGO
323:pattern
181:9q34.12
81:3630329
49:Aliases
1522:
1515:139241
1512:
1469:
1434:
1399:
1392:299975
1389:
1346:
1339:528928
1336:
1303:
1295:
1266:
1258:
1221:
1213:
1154:
1113:
968:GPR103
911:search
909:PubMed
784:Q8CE23
765:P83859
694:227717
675:347148
661:Entrez
494:BioGPS
468:uterus
460:spleen
432:embryo
73:609795
1555:is a
1301:S2CID
1264:S2CID
1219:S2CID
654:Mouse
649:Human
620:Amigo
374:gonad
346:Mouse
339:Human
286:Start
221:Mouse
185:Start
118:Human
89:52341
1557:stub
1549:gene
1520:PMID
1467:PMID
1432:PMID
1397:PMID
1344:PMID
1293:PMID
1256:PMID
1236:1040
1211:PMID
1152:PMID
1111:PMID
957:P518
329:Bgee
277:Band
238:Chr.
176:Band
135:Chr.
97:QRFP
69:OMIM
56:QRFP
33:QRFP
1510:PMC
1500:doi
1457:doi
1453:278
1422:doi
1418:278
1387:PMC
1377:doi
1365:100
1334:PMC
1326:doi
1285:doi
1248:doi
1203:doi
1142:doi
1138:278
1101:doi
1097:278
502:n/a
456:lip
299:End
198:End
101:OMA
77:MGI
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