Knowledge (XXG)

Pyronaridine

Source ๐Ÿ“

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It has also been studied as a potential anticancer drug, and treatment for Ebola. The combination of pyronaridine and artesunate has been evaluated to have a synergistic effect of stronger antiviral effect and less toxicity. The combination of pyronaridine and artesunate is being studied as a
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InChI=1S/C29H32ClN5O2/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35/h6-9,14-16,36H,2-5,10-13,17-18H2,1H3,(H,31,32)
776: 68: 390: 1526: 332: 346: 769: 1545: 762: 1519: 1441: 1560: 1084: 366: 1512: 425: 113: 89: 754: 1313: 877: 1555: 1550: 579: 195: 598:"Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis" 1458: 235: 1157: 540:"Efficacy of oral pyronaridine for the treatment of acute uncomplicated falciparum malaria in African children" 1446: 1308: 1285: 1052: 428: 57: 49: 1296: 1172: 1128: 1302: 224: 417:
In a small (n=88) malaria study in Camaroon, pyronaridine had a 100% cure rate, compared with 60% for
1222: 609: 251: 1492: 789: 657:"Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection" 503:
Chang C, Lin-Hua T, Jantanavivat C (1992). "Studies on a new antimalarial compound: pyronaridine".
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Croft SL, Duparc S, Arbe-Barnes SJ, Craft JC, Shin CS, Fleckenstein L, et al. (August 2012).
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Lane TR, Massey C, Comer JE, Anantpadma M, Freundlich JS, Davey RA, et al. (November 2019).
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Villanueva PJ, Martinez A, Baca ST, DeJesus RE, Larragoity M, Contreras L, et al. (2018).
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CLP (EU): Acute Tox. 3(H301), Eye Dam. 1 (H318), Repr. 2 (H361), Aquatic Chronic 4 (H413)
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Transactions of the Royal Society of Tropical Medicine and Hygiene
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Clc1ccc6c(c1)nc2ccc(OC)nc2c6Nc5cc(CN3CCCC3)c(O)c(CN4CCCC4)c5
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4-quinolin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol
711:"Repurposing Antimalarials to Tackle the COVID-19 Pandemic" 1500: 397: 435:
possible treatment for moderate to severe SARS-COV-2.
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European Medicines Agency. 2016. 14: 1480: 661:PLOS Neglected Tropical Diseases 292: 289: 283: 426:artemisinin combination therapy 379:Key:DJUFPMUQJKWIJB-UHFFFAOYSA-N 1546:Drugs not assigned an ATC code 1314:piperaquine/dihydroartemisinin 298: 277: 1: 878:trimethoprim/sulfamethoxazole 1276:Fixed-dose (co-formulated) 674:10.1371/journal.pntd.0007890 623:10.1371/journal.pone.0206467 544:Clinical Infectious Diseases 517:10.1016/0035-9203(92)90414-8 44:Pyronaridine tetraphosphate 1577: 1475: 267:Chemical and physical data 1561:Antiinfective agent stubs 1436: 1158:sulfadoxine/pyrimethamine 387: 362: 342: 109: 26: 727:10.1016/j.pt.2020.10.003 471:10.1186/1475-2875-11-270 1309:artesunate/pyronaridine 1286:artemether/lumefantrine 429:pyronaridine/artesunate 58:intramuscular injection 1297:artesunate/amodiaquine 715:Trends in Parasitology 1331:artesunate/mefloquine 1303:artesunate/mefloquine 1343:quinine/tetracycline 1015:4-Methanolquinolines 790:antiprotozoal agents 1556:Chinese discoveries 1551:Antimalarial agents 1340:quinine/doxycycline 1337:quinine/clindamycin 1325:(not co-formulated) 614:2018PLoSO..1306467V 62:intravenous therapy 23: 1463:Never to phase III 1323:Other combinations 1203:dihydroartemisinin 985:hydroxychloroquine 1508: 1507: 1473: 1472: 1408: 1407: 1380: 1379: 1376: 1375: 1354: 1353: 1350: 1349: 1262: 1261: 1167: 1166: 1070: 1069: 919: 918: 845:Cryptosporidiosis 412:antimalarial drug 405: 404: 333:Interactive image 236:CompTox Dashboard 16:Chemical compound 1568: 1529: 1522: 1515: 1484: 1477: 1273: 1081: 959: 948: 939: 930: 841: 825: 814: 796:antiparasitics ( 779: 772: 765: 756: 749: 748: 738: 703: 697: 696: 686: 676: 667:(11): e0007890. 652: 646: 645: 635: 625: 608:(11): e0206467. 593: 587: 586: 584: 576: 570: 569: 559: 535: 529: 528: 500: 494: 493: 483: 473: 449: 401: 400: 393: 335: 315: 300: 294: 291: 285: 279: 259: 258: 244: 242: 227: 207: 187: 167: 157: 156: 142: 31: 24: 22: 1576: 1575: 1571: 1570: 1569: 1567: 1566: 1565: 1536: 1535: 1534: 1533: 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835:Coccidiostats 830: 826: 823: 821: 815: 812: 810: 804: 799: 795: 791: 787: 780: 775: 773: 768: 766: 761: 760: 757: 746: 742: 737: 732: 728: 724: 720: 716: 712: 708: 702: 699: 694: 690: 685: 680: 675: 670: 666: 662: 658: 651: 648: 643: 639: 634: 629: 624: 619: 615: 611: 607: 603: 599: 592: 589: 581: 575: 572: 567: 563: 558: 553: 549: 545: 541: 534: 531: 526: 522: 518: 514: 510: 506: 499: 496: 491: 487: 482: 477: 472: 467: 463: 459: 455: 448: 445: 438: 436: 432: 430: 427: 422: 420: 415: 413: 409: 399: 392: 386: 377: 372: 368: 361: 352: 348: 341: 334: 330: 329: 327: 324: 319: 312: 310: 306: 276: 274: 270: 265: 257: 253: 249: 248: 246: 237: 233: 226: 222: 221: 219: 217: 213: 206: 202: 201: 199: 197: 193: 186: 182: 181: 179: 177: 173: 166: 162: 161: 159: 152: 148: 141: 137: 136: 134: 132: 128: 119: 115: 108: 103: 96: 95: 93: 91: 87: 82: 75: 74: 72: 70: 66: 63: 59: 55: 53: 47: 43: 39: 36:Clinical data 34: 30: 25: 1501:expanding it 1487: 1400:tetracycline 1293:/piperaquine 1249:pyronaridine 1248: 1229:tetracycline 1129:Sulfonamides 1104: 1062:halofantrine 1053:+ artemether 1048:lumefantrine 925:Aconoidasida 901:sulfadiazine 870:Isosporiasis 859:nitazoxanide 852: 718: 714: 701: 664: 660: 650: 605: 601: 591: 574: 547: 543: 533: 508: 504: 498: 461: 457: 447: 433: 423: 416: 408:Pyronaridine 407: 406: 395:   389:   90:Legal status 84:Legal status 21:Pyronaridine 1449:from market 1368:clindamycin 1254:piperaquine 1239:clindamycin 1234:doxycycline 1223:+ proguanil 1188:artemisinin 1137:sulfadoxine 1098:cycloguanil 1076:Antifolates 1006:tafenoquine 980:chloroquine 975:amodiaquine 942:Individual 906:clindamycin 854:thiazolides 829:Conoidasida 721:(1): 8โ€“11. 511:(1): 7โ€“10. 431:(Pyramax). 419:chloroquine 316: gยทmol 225:ChEMBL35228 105:Identifiers 41:Other names 1540:Categories 1360:Babesiosis 1291:arterolane 1219:atovaquone 1198:artesunate 1183:artemether 1106:biguanides 1022:mefloquine 996:primaquine 954:inhibitors 911:atovaquone 439:References 321:3D model ( 309:Molar mass 205:TD3P7Q3SG6 176:ChemSpider 140:74847-35-1 131:CAS Number 114:IUPAC name 1459:Phase III 1447:Withdrawn 1244:mepacrine 1193:artemotil 1142:sulfalene 1117:proguanil 1032:quinidine 1001:pamaquine 707:Krishna S 580:"Pyramax" 50:Routes of 1414:Stramen- 1175:lactones 952:Hemozoin 745:33153922 693:31751347 642:30395606 602:PLOS ONE 490:22877082 398:(verify) 185:10647812 69:ATC code 1269:nations 1027:quinine 934:Malaria 818:Apicom- 736:7572038 684:6894882 633:6218039 610:Bibcode 566:9564481 525:1566313 481:3483207 464:: 270. 273:Formula 165:5485198 151:PubChem 1442:WHO-EM 1386:Cilio- 1305:(ASMQ) 1299:(ASAQ) 1267:Combi- 944:agents 807:Alveo- 743:  733:  691:  681:  640:  630:  564:  523:  488:  478:  410:is an 347:SMILES 314:518.06 216:ChEMBL 56:Oral, 1488:This 1416:opile 1388:phora 1212:Other 1041:Other 820:plexa 583:(PDF) 367:InChI 323:JSmol 1497:stub 1493:drug 1278:ACTs 1160:(SP) 992:(8-) 971:(4-) 809:late 741:PMID 689:PMID 638:PMID 562:PMID 521:PMID 486:PMID 196:UNII 76:none 798:P01 731:PMC 723:doi 679:PMC 669:doi 628:PMC 618:doi 552:doi 513:doi 476:PMC 466:doi 241:EPA 155:CID 1542:: 1455:: 1426:: 1398:: 994:: 973:: 792:โ€“ 788:โ€“ 739:. 729:. 719:37 717:. 713:. 687:. 677:. 665:13 663:. 659:. 636:. 626:. 616:. 606:13 604:. 600:. 560:. 548:26 546:. 542:. 519:. 509:86 507:. 484:. 474:. 462:11 460:. 456:. 421:. 290:Cl 287:32 281:29 60:, 1528:e 1521:t 1514:v 1503:. 1225:) 1221:( 861:) 857:( 837:) 833:( 831:/ 800:) 778:e 771:t 764:v 747:. 725:: 695:. 671:: 644:. 620:: 612:: 568:. 554:: 527:. 515:: 492:. 468:: 325:) 302:2 299:O 296:5 293:N 284:H 278:C 243:) 239:(

Index

A chemical diagram of a Pyronaridine molecule
Routes of
administration

intramuscular injection
intravenous therapy
ATC code
Legal status
IUPAC name
CAS Number
74847-35-1
PubChem
5485198
ChemSpider
10647812
UNII
TD3P7Q3SG6
ChEMBL
ChEMBL35228
CompTox Dashboard
DTXSID60996354
Edit this at Wikidata
Formula
Molar mass
JSmol
Interactive image
SMILES
InChI
(what is this?)
(verify)
antimalarial drug
chloroquine

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