244:
221:
118:
143:
1022:
bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in
Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
250:
149:
1850:
1021:
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile
Parkinson's disease. These genes are co-regulated in various tissues and they share a
1785:
Taylor JM, Song YJ, Huang Y, Farrer MJ, Delatycki MB, Halliday GM, et al. (2007). "Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of
Parkinsonian diseases".
1666:"Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia"
1576:
257:
156:
1488:
Lockhart PJ, O'Farrell CA, Farrer MJ (2004). "It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG)".
1293:
Mira MT, Alcaïs A, Van Thuc N, Thai VH, Huong NT, Ba NN, et al. (2003). "Chromosome 6q25 is linked to susceptibility to leprosy in a
Vietnamese population".
1174:
Schurr E, Alcaïs A, de Léséleuc L, Abel L (2006). "Genetic predisposition to leprosy: A major gene reveals novel pathways of immunity to
Mycobacterium leprae".
1709:"Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian population"
1627:
Deng H, Le WD, Xie WJ, Pan TH, Zhang X, Jankovic J (2005). "Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonism".
710:
1443:
Mira MT, Alcaïs A, Nguyen VT, Moraes MO, Di
Flumeri C, Hong Thai V, et al. (2004). "Susceptibility to leprosy is associated with PARK2 and PACRG".
729:
79:
1919:
1081:
1895:
1099:
1914:
1117:
West AB, Lockhart PJ, O'Farell C, Farrer MJ (Jan 2003). "Identification of a novel gene linked to parkin via a bi-directional promoter".
243:
945:
952:
220:
1155:
1068:
1047:
1332:"A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death"
1064:
142:
117:
1043:
59:
256:
155:
1203:
Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, et al. (2001). "The sequence of the human genome".
249:
148:
1888:
1538:
774:
67:
1586:"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"
755:
1570:
1664:
Agirre X, Román-Gómez J, Vázquez I, Jiménez-Velasco A, Garate L, Montiel-Duarte C, et al. (2006).
1881:
1452:
1378:
1253:
1212:
131:
46:
1823:
Udina IG, Kordicheva SIu, Pospelov LE, Malenko AF, Gergert V, Pospelov AL, et al. (2007). "".
903:
899:
848:
844:
1811:
1773:
1695:
1652:
1558:
1513:
1476:
1318:
91:
1525:
Buschman E, Skamene E (2004). "Linkage of leprosy susceptibility to
Parkinson's disease genes".
1242:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
928:
907:
873:
852:
50:, GLUP, HAK005771, PARK2CRG, PARK2 co-regulated, PARK2 coregulated, parkin coregulated, PACRG2.1
1828:
1803:
1765:
1730:
1687:
1644:
1615:
1550:
1542:
1505:
1468:
1431:
1396:
1353:
1310:
1281:
1240:
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003).
1228:
1191:
1134:
39:
1865:
1795:
1755:
1720:
1677:
1636:
1605:
1597:
1534:
1497:
1460:
1421:
1386:
1343:
1302:
1271:
1261:
1220:
1183:
1126:
336:
267:
211:
166:
87:
311:
1584:
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004).
1456:
1382:
1257:
1216:
1365:
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, et al. (2003).
1610:
1585:
1276:
1241:
1130:
644:
639:
634:
618:
613:
608:
603:
598:
593:
588:
583:
567:
562:
557:
552:
547:
542:
537:
532:
527:
1908:
514:
1815:
1777:
1699:
1656:
1562:
1322:
71:
1861:
1480:
329:
108:
1742:
Lesage S, Magali P, Lohmann E, Lacomblez L, Teive H, Janin S, et al. (2007).
1517:
1640:
95:
1707:
Malhotra D, Darvishi K, Lohra M, Kumar H, Grover C, Sood S, et al. (2006).
1408:
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004).
1104:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1086:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1187:
412:
1799:
228:
125:
75:
1546:
1744:"Deletion of the parkin and PACRG gene promoter in early-onset parkinsonism"
1725:
1708:
1410:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
1224:
674:
472:
350:
295:
282:
194:
181:
83:
1832:
1807:
1769:
1734:
1691:
1648:
1619:
1554:
1509:
1472:
1435:
1400:
1357:
1348:
1331:
1314:
1285:
1266:
1232:
1195:
1138:
992:
987:
976:
819:
800:
1464:
1391:
1366:
1760:
1743:
1601:
1008:
786:
741:
1682:
1665:
1501:
960:
696:
1849:
1426:
1409:
1306:
1527:
International
Journal of Leprosy and Other Mycobacterial Diseases
659:
655:
1857:
1330:
Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (2004).
1015:
63:
1539:
10.1489/1544-581X(2004)072<0169:LOLSTP>2.0.CO;2
319:
1869:
1367:"The DNA sequence and analysis of human chromosome 6"
484:
921:
892:
866:
837:
1060:
1058:
1056:
1039:
1037:
1035:
266:
165:
1246:Proceedings of the National Academy of Sciences
16:Protein-coding gene in the species Homo sapiens
1065:GRCm38: Ensembl release 89: ENSMUSG00000037196
1889:
1575:: CS1 maint: DOI inactive as of April 2024 (
8:
1044:GRCh38: Ensembl release 89: ENSG00000112530
1896:
1882:
670:
510:
307:
206:
103:
1759:
1724:
1681:
1609:
1425:
1390:
1347:
1275:
1265:
1150:
1148:
1825:Problemy Tuberkuleza I Bolezneĭ Legkikh
1156:"Entrez Gene: PACRG PARK2 co-regulated"
1031:
1568:
20:
271:
232:
227:
170:
129:
124:
7:
1846:
1844:
1868:. You can help Knowledge (XXG) by
1713:European Journal of Human Genetics
918:
889:
863:
834:
810:
791:
765:
746:
720:
701:
553:G protein-coupled receptor binding
489:
447:choroid plexus of fourth ventricle
407:
345:
324:
14:
1011:that in humans is encoded by the
635:negative regulation of cell death
1848:
563:ubiquitin protein ligase binding
439:lumbar subsegment of spinal cord
255:
248:
242:
219:
154:
147:
141:
116:
1670:International Journal of Cancer
1336:Journal of Biological Chemistry
1005:Parkin coregulated gene protein
473:More reference expression data
369:olfactory zone of nasal mucosa
1:
1920:Human chromosome 6 gene stubs
1131:10.1016/S0022-2836(02)01376-1
240:
139:
1641:10.1016/j.neulet.2005.03.034
1119:Journal of Molecular Biology
459:Epithelium of choroid plexus
455:anterior horn of spinal cord
1915:Genes on human chromosome 6
1936:
1843:
1188:10.1016/j.smim.2006.07.005
558:heat shock protein binding
1800:10.1016/j.nbd.2007.04.014
1100:"Mouse PubMed Reference:"
1082:"Human PubMed Reference:"
991:
986:
982:
975:
959:
946:Chr 6: 162.73 – 163.32 Mb
940:
925:
896:
885:
870:
841:
830:
817:
813:
798:
794:
785:
772:
768:
753:
749:
740:
727:
723:
708:
704:
695:
680:
673:
669:
653:
640:Unfolded Protein Response
513:
509:
497:
492:
483:
470:
419:
410:
393:mucosa of paranasal sinus
361:bronchial epithelial cell
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
953:Chr 17: 10.62 – 11.06 Mb
1788:Neurobiology of Disease
1726:10.1038/sj.ejhg.5201563
1541:(inactive 2024-04-08).
1225:10.1126/science.1058040
1349:10.1074/jbc.M309655200
1267:10.1073/pnas.242603899
1176:Seminars in Immunology
645:spermatid development
543:alpha-tubulin binding
533:Hsp90 protein binding
528:Hsp70 protein binding
234:Chromosome 17 (mouse)
1629:Neuroscience Letters
568:beta-tubulin binding
435:olfactory epithelium
427:facial motor nucleus
273:17 A1|17 7.8 cM
132:Chromosome 6 (human)
1465:10.1038/nature02326
1457:2004Natur.427..636M
1392:10.1038/nature02055
1383:2003Natur.425..805M
1258:2002PNAS...9916899M
1217:2001Sci...291.1304V
423:seminiferous tubule
1856:This article on a
1761:10.1002/humu.20436
1602:10.1101/gr.2596504
1490:Movement Disorders
775:ENSMUSG00000037196
628:Biological process
577:Cellular component
521:Molecular function
385:anterior pituitary
365:right uterine tube
1877:
1876:
1683:10.1002/ijc.21584
1502:10.1002/mds.20000
1252:(26): 16899–903.
1211:(5507): 1304–51.
1002:
1001:
998:
997:
971:
970:
936:
935:
915:
914:
881:
880:
860:
859:
826:
825:
807:
806:
781:
780:
762:
761:
736:
735:
717:
716:
665:
664:
599:neuron projection
548:chaperone binding
505:
504:
501:
500:
479:
478:
466:
465:
404:
403:
302:
301:
201:
200:
96:PACRG - orthologs
1927:
1898:
1891:
1884:
1852:
1845:
1836:
1819:
1781:
1763:
1738:
1728:
1703:
1685:
1660:
1623:
1613:
1580:
1574:
1566:
1521:
1484:
1451:(6975): 636–40.
1439:
1429:
1404:
1394:
1377:(6960): 805–11.
1361:
1351:
1342:(51): 51901–10.
1326:
1289:
1279:
1269:
1236:
1199:
1160:
1159:
1152:
1143:
1142:
1114:
1108:
1107:
1096:
1090:
1089:
1078:
1072:
1062:
1051:
1041:
984:
983:
955:
948:
931:
919:
910:
890:
886:RefSeq (protein)
876:
864:
855:
835:
811:
792:
766:
747:
721:
702:
671:
511:
490:
475:
451:secondary oocyte
415:
413:Top expressed in
408:
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
49:
42:
21:
1935:
1934:
1930:
1929:
1928:
1926:
1925:
1924:
1905:
1904:
1903:
1902:
1841:
1839:
1822:
1784:
1741:
1706:
1663:
1626:
1596:(10B): 2121–7.
1590:Genome Research
1583:
1567:
1524:
1487:
1442:
1414:Nature Genetics
1407:
1364:
1329:
1295:Nature Genetics
1292:
1239:
1202:
1173:
1169:
1167:Further reading
1164:
1163:
1154:
1153:
1146:
1116:
1115:
1111:
1098:
1097:
1093:
1080:
1079:
1075:
1063:
1054:
1042:
1033:
1028:
993:View/Edit Mouse
988:View/Edit Human
951:
944:
941:Location (UCSC)
927:
906:
902:
898:
872:
851:
847:
843:
756:ENSG00000112530
649:
623:
572:
471:
462:
457:
453:
449:
445:
441:
437:
433:
429:
425:
411:
400:
395:
391:
387:
383:
379:
375:
371:
367:
363:
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
17:
12:
11:
5:
1933:
1931:
1923:
1922:
1917:
1907:
1906:
1901:
1900:
1893:
1886:
1878:
1875:
1874:
1853:
1838:
1837:
1820:
1782:
1748:Human Mutation
1739:
1704:
1676:(8): 1945–53.
1661:
1624:
1581:
1522:
1485:
1440:
1427:10.1038/ng1285
1405:
1362:
1327:
1307:10.1038/ng1096
1290:
1237:
1200:
1170:
1168:
1165:
1162:
1161:
1144:
1109:
1091:
1073:
1052:
1030:
1029:
1027:
1024:
1000:
999:
996:
995:
990:
980:
979:
973:
972:
969:
968:
966:
964:
957:
956:
949:
942:
938:
937:
934:
933:
923:
922:
916:
913:
912:
894:
893:
887:
883:
882:
879:
878:
868:
867:
861:
858:
857:
839:
838:
832:
828:
827:
824:
823:
815:
814:
808:
805:
804:
796:
795:
789:
783:
782:
779:
778:
770:
769:
763:
760:
759:
751:
750:
744:
738:
737:
734:
733:
725:
724:
718:
715:
714:
706:
705:
699:
693:
692:
687:
682:
678:
677:
667:
666:
663:
662:
651:
650:
648:
647:
642:
637:
631:
629:
625:
624:
622:
621:
616:
611:
606:
604:sperm midpiece
601:
596:
591:
586:
580:
578:
574:
573:
571:
570:
565:
560:
555:
550:
545:
540:
535:
530:
524:
522:
518:
517:
507:
506:
503:
502:
499:
498:
495:
494:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
231:
225:
224:
216:
215:
203:
202:
199:
198:
190:
186:
185:
177:
174:
169:
163:
162:
153:
146:
140:
136:
135:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
1932:
1921:
1918:
1916:
1913:
1912:
1910:
1899:
1894:
1892:
1887:
1885:
1880:
1879:
1873:
1871:
1867:
1863:
1859:
1854:
1851:
1847:
1842:
1834:
1830:
1826:
1821:
1817:
1813:
1809:
1805:
1801:
1797:
1794:(2): 238–47.
1793:
1789:
1783:
1779:
1775:
1771:
1767:
1762:
1757:
1753:
1749:
1745:
1740:
1736:
1732:
1727:
1722:
1719:(4): 438–42.
1718:
1714:
1710:
1705:
1701:
1697:
1693:
1689:
1684:
1679:
1675:
1671:
1667:
1662:
1658:
1654:
1650:
1646:
1642:
1638:
1634:
1630:
1625:
1621:
1617:
1612:
1607:
1603:
1599:
1595:
1591:
1587:
1582:
1578:
1572:
1564:
1560:
1556:
1552:
1548:
1544:
1540:
1536:
1533:(2): 169–70.
1532:
1528:
1523:
1519:
1515:
1511:
1507:
1503:
1499:
1495:
1491:
1486:
1482:
1478:
1474:
1470:
1466:
1462:
1458:
1454:
1450:
1446:
1441:
1437:
1433:
1428:
1423:
1419:
1415:
1411:
1406:
1402:
1398:
1393:
1388:
1384:
1380:
1376:
1372:
1368:
1363:
1359:
1355:
1350:
1345:
1341:
1337:
1333:
1328:
1324:
1320:
1316:
1312:
1308:
1304:
1300:
1296:
1291:
1287:
1283:
1278:
1273:
1268:
1263:
1259:
1255:
1251:
1247:
1243:
1238:
1234:
1230:
1226:
1222:
1218:
1214:
1210:
1206:
1201:
1197:
1193:
1189:
1185:
1182:(6): 404–10.
1181:
1177:
1172:
1171:
1166:
1157:
1151:
1149:
1145:
1140:
1136:
1132:
1128:
1124:
1120:
1113:
1110:
1105:
1101:
1095:
1092:
1087:
1083:
1077:
1074:
1070:
1066:
1061:
1059:
1057:
1053:
1049:
1045:
1040:
1038:
1036:
1032:
1025:
1023:
1019:
1017:
1014:
1010:
1006:
994:
989:
985:
981:
978:
974:
967:
965:
962:
958:
954:
950:
947:
943:
939:
932:
930:
924:
920:
917:
911:
909:
905:
901:
895:
891:
888:
884:
877:
875:
869:
865:
862:
856:
854:
850:
846:
840:
836:
833:
831:RefSeq (mRNA)
829:
822:
821:
816:
812:
809:
803:
802:
797:
793:
790:
788:
784:
777:
776:
771:
767:
764:
758:
757:
752:
748:
745:
743:
739:
732:
731:
726:
722:
719:
713:
712:
707:
703:
700:
698:
694:
691:
688:
686:
683:
679:
676:
672:
668:
661:
657:
652:
646:
643:
641:
638:
636:
633:
632:
630:
627:
626:
620:
617:
615:
614:mitochondrion
612:
610:
607:
605:
602:
600:
597:
595:
592:
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538:actin binding
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515:Gene ontology
512:
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27:
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1870:expanding it
1862:chromosome 6
1855:
1840:
1824:
1791:
1787:
1754:(1): 27–32.
1751:
1747:
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1673:
1669:
1635:(3): 297–9.
1632:
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1571:cite journal
1530:
1526:
1496:(1): 101–4.
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1339:
1335:
1301:(3): 412–5.
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926:
904:NP_001073848
900:NP_001073847
897:
871:
849:NM_001080379
845:NM_001080378
842:
818:
799:
773:
754:
728:
709:
689:
684:
443:spermatocyte
377:right testis
335:
328:
193:163,315,500
180:162,727,132
55:External IDs
18:
1827:(7): 27–9.
1420:(1): 40–5.
1125:(1): 11–9.
373:left testis
294:11,059,198
281:10,621,941
33:Identifiers
1909:Categories
1071:, May 2017
1050:, May 2017
1026:References
339:(ortholog)
76:HomoloGene
1860:on human
1547:1544-581X
929:NP_081308
908:NP_689623
874:NM_027032
853:NM_152410
675:Orthologs
584:cell body
431:spermatid
84:GeneCards
1833:17722288
1816:37510774
1808:17590346
1778:41107588
1770:17068781
1735:16391553
1700:13254869
1692:16287063
1657:28541531
1649:15925106
1620:15489334
1563:43103579
1555:15301585
1510:14743368
1473:14737177
1436:14702039
1401:14574404
1358:14532270
1323:35810055
1315:12577057
1286:12477932
1233:11181995
1196:16973374
1139:12547187
1067:–
1046:–
977:Wikidata
654:Sources:
1481:4344440
1453:Bibcode
1379:Bibcode
1254:Bibcode
1213:Bibcode
1205:Science
1069:Ensembl
1048:Ensembl
1009:protein
787:UniProt
742:Ensembl
681:Species
660:QuickGO
619:nucleus
594:cytosol
589:vesicle
314:pattern
72:1916560
40:Aliases
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1277:139241
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963:search
961:PubMed
820:Q9DAK2
801:Q96M98
711:135138
697:Entrez
609:cilium
485:BioGPS
64:608427
1864:is a
1812:S2CID
1774:S2CID
1696:S2CID
1653:S2CID
1559:S2CID
1514:S2CID
1477:S2CID
1319:S2CID
1013:PACRG
1007:is a
730:69310
690:Mouse
685:Human
656:Amigo
389:gonad
381:sperm
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
88:PACRG
80:16212
47:PACRG
24:PACRG
1866:stub
1858:gene
1829:PMID
1804:PMID
1766:PMID
1731:PMID
1688:PMID
1645:PMID
1616:PMID
1577:link
1551:PMID
1543:ISSN
1506:PMID
1469:PMID
1432:PMID
1397:PMID
1354:PMID
1311:PMID
1282:PMID
1229:PMID
1192:PMID
1135:PMID
1016:gene
320:Bgee
268:Band
229:Chr.
172:6q26
167:Band
126:Chr.
60:OMIM
1796:doi
1756:doi
1721:doi
1678:doi
1674:118
1637:doi
1633:382
1606:PMC
1598:doi
1535:doi
1498:doi
1461:doi
1449:427
1422:doi
1387:doi
1375:425
1344:doi
1340:278
1303:doi
1272:PMC
1262:doi
1221:doi
1209:291
1184:doi
1127:doi
1123:326
493:n/a
290:End
189:End
92:OMA
68:MGI
1911::
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296:bp
283:bp
195:bp
182:bp
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