29:
688:
Although the PAS domain exhibits a degree of sequence variability, the three-dimensional structure of the PAS domain core is broadly conserved. This core consists of a five-stranded antiparallel β-sheet and several α-helices. Structural changes, as a result of signaling, predominantly originate
997:
Liu, Yu C.; Machuca, Mayra A.; Beckham, Simone A.; Gunzburg, Menachem J.; Roujeinikova, Anna (1 October 2015). "Structural basis for amino-acid recognition and transmembrane signalling by tandem Per-Arnt-Sim (tandem PAS) chemoreceptor sensory domains".
636:
found in all kingdoms of life. Generally, the PAS domain acts as a molecular sensor, whereby small molecules and other proteins associate via binding of the PAS domain. Due to this sensing capability, the PAS domain has been shown as the key
840:
Within
Mammals, both PAS domains play important roles. PAS A is responsible for the protein-protein interactions with other PAS domain proteins, while PAS B has a more versatile role. It mediates interactions with
719:
identity, meaning they are surprisingly dissimilar. PAS domains are frequently found on proteins with other environmental sensing mechanisms. Also, many PAS domains are attached to photoreceptive cells.
872:
of the BHLH protein. PAS domains containing BHLH proteins form a BHLH-Pas protein, typically found and encoded in HIF, which require both the PAS domain and BHLH domain and the Clock gene.
861:
binding. Furthermore, PAS domains containing the NPAS2 protein have been shown to be a substitute for the Clock gene in mutant mice who lack the Clock gene completely.
189:
1473:
653:
PAS domains are found in a large number of organisms from bacteria to mammals. The PAS domain was named after the three proteins in which it was first discovered:
664:
828:
to bind via their PAS domains. That activator complex regulates Per1, Per2, and Per3 which all have PAS domains that are used to bind to cryptochromes 1 and 2 (
676:
Since the initial discovery of the PAS domain, a large quantity of PAS domain binding sites have been discovered in bacteria and eukaryotes. A subset called
1777:
101:
33:
Crystallographic structure of the PAS domain of the bacterial oxygen sensor protein fixL. The protein is depicted as a rainbow colored cartoon (
1974:
697:
of the core to the covalently-attached effector domain. In 1998, the PAS domain core architecture was first characterized in the structure of
125:
1093:
Hennig, Sven; Strauss, Holger M.; Vanselow, Katja; Yildiz, Özkan; Schulze, Sabrina; Arens, Julia; Kramer, Achim; Wolf, Eva (28 April 2009).
707:. In many proteins, a dimer of PAS domains is required, whereby one binds a ligand and the other mediates interactions with other proteins.
2024:
737:
677:
1969:
846:
1434:
McIntosh, Brian; Hogenesch, John; Bradfield, Christopher (2010). "Mammalian Per-Arnt-Sim
Proteins in Environmental Adaptation".
1984:
2107:
1892:
209:
1847:
1770:
1337:
952:
1095:"Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2"
901:"A distal arginine in oxygen-sensing heme-PAS domains is essential to ligand binding, signal transduction, and structure"
1436:
728:
Often in the bacterial kingdom, PAS domains are positioned at the amino terminus of signaling proteins such as sensor
832:
family). The following mammalian genes contain PAS binding domains: Per1, Per2, Per3, Cry1, Cry2, Bmal, Clk, Pasd1.
2036:
1471:
Harmer, Stacey L.; Panda, Satchidananda; Kay, Steve A. (28 November 2003). "Molecular Bases of
Circadian Rhythms".
698:
854:
145:
1763:
808:
A PAS domain is found in the ZTL and NPH1 genes. These domains are very similar to the PAS domain found in the
703:
197:
760:(WC-1) and White Collar-2 (WC-2) dimerizes via mediation by the PAS domains, which activates translation of
865:
1702:"Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension"
1145:
1927:
858:
645:, and it is also a common motif found in signaling proteins, where it functions as a signaling sensor.
193:
1713:
1007:
138:
150:
106:
2102:
2009:
2076:
1994:
1682:
1588:
1539:
1175:
928:
716:
2071:
1741:
1674:
1639:
1580:
1531:
1490:
1453:
1413:
1364:
1306:
1265:
1216:
1167:
1126:
1072:
1023:
979:
920:
889:
792:
via the PER PAS domain. The following genes contain PAS binding domains: PER, Tim, CLK, CYC.
216:
184:
2061:
1731:
1721:
1666:
1629:
1619:
1570:
1521:
1482:
1445:
1403:
1395:
1354:
1346:
1296:
1255:
1247:
1206:
1157:
1116:
1106:
1062:
1054:
1015:
969:
961:
912:
761:
729:
638:
176:
1449:
789:
642:
899:
Dunham CM, Dioum EM, Tuckerman JR, Gonzalez G, Scott WG, Gilles-Gonzalez MA (July 2003).
820:
The circadian clock that is currently understood for mammals begins when light activates
45:
ligand is shown as sticks (carbon = white, nitrogen = blue, oxygen = red, iron = orange).
1717:
1350:
1011:
965:
1999:
1862:
1786:
1408:
1383:
1359:
1332:
1260:
1235:
1121:
1094:
1067:
1042:
974:
947:
757:
633:
1634:
1607:
1526:
1509:
1162:
2096:
1932:
1736:
1701:
1486:
1211:
1194:
788:
attach via a PAS domain, activating the translation of PER, which then associates to
733:
658:
130:
1592:
1179:
932:
69:
2014:
1937:
1922:
1882:
1817:
1686:
1543:
829:
785:
172:
1657:
Ke, Qingdong; Costa, Max (1 November 2006). "Hypoxia-Inducible Factor-1 (HIF-1)".
82:
1575:
1558:
1195:"The PAS fold. A redefinition of the PAS domain based upon structural prediction"
1111:
94:
2081:
2066:
1989:
1979:
1959:
1954:
1949:
1912:
1867:
1842:
1827:
1822:
1807:
1557:
Debruyne JP, Noton E, Lambert CM, Maywood ES, Weaver DR, Reppert SM (May 2006).
803:
694:
1706:
Proceedings of the
National Academy of Sciences of the United States of America
2056:
2051:
2046:
2031:
2004:
1944:
1917:
1907:
1902:
1897:
1887:
1857:
1852:
1837:
1832:
1812:
1802:
1559:"A clock shock: mouse CLOCK is not required for circadian oscillator function"
1399:
1251:
1058:
1019:
869:
842:
775:
751:
690:
38:
34:
2041:
1964:
1877:
1872:
1797:
1726:
1624:
1301:
1284:
900:
1678:
1670:
1643:
1584:
1535:
1494:
1457:
1417:
1368:
1333:"Ligand-Binding PAS Domains in a Genomic, Cellular, and Structural Context"
1310:
1269:
1220:
1130:
1076:
1027:
983:
948:"Ligand-binding PAS domains in a genomic, cellular, and structural context"
924:
1745:
1171:
134:
89:
1510:"ZEITLUPE Encodes a Novel Clock-Associated PAS Protein from Arabidopsis"
1283:
Rosato, Ezio; Tauber, Eran; Kyriacou, Charalambos P. (1 January 2006).
1193:
Hefti MH, Françoijs KJ, de Vries SC, Dixon R, Vervoort J (March 2004).
118:
113:
1508:
Somers, David; Schultz, Thomas; Kay, Steve; Milnamow, Maureen (2000).
1234:
Möglich, Andreas; Ayers, Rebecca A.; Moffat, Keith (14 October 2009).
1041:
Möglich, Andreas; Ayers, Rebecca A.; Moffat, Keith (14 October 2009).
916:
893:
606:
600:
594:
588:
582:
576:
570:
564:
558:
552:
546:
540:
534:
528:
522:
516:
510:
504:
498:
492:
486:
480:
474:
468:
462:
456:
450:
444:
438:
432:
426:
420:
414:
408:
402:
396:
390:
384:
378:
372:
366:
360:
354:
348:
342:
336:
330:
324:
318:
312:
306:
300:
294:
288:
282:
276:
270:
264:
258:
252:
246:
240:
234:
228:
222:
28:
1700:
Wang, G. L.; Jiang, B. H.; Rue, E. A.; Semenza, G. L. (6 June 1995).
204:
1755:
850:
825:
821:
781:
670:
166:
76:
64:
42:
1759:
1384:"Structure and Signaling Mechanism of Per-ARNT-Sim Domains"
1236:"Structure and Signaling Mechanism of Per-ARNT-Sim Domains"
1043:"Structure and signaling mechanism of Per-ARNT-Sim domains"
715:
The PAS domains that are known share less than 20% average
1146:"PAS: a multi-functional domain family comes to light"
680:
proteins are responsive to oxygen, light and voltage.
665:
aryl hydrocarbon receptor nuclear translocator protein
1285:"Molecular genetics of the fruit-fly circadian clock"
1608:"An overview of the basic helix-loop-helix proteins"
1331:
Henry, Jonathan T.; Crosson, Sean (1 January 2011).
946:
Henry, Jonathan T.; Crosson, Sean (1 January 2011).
215:
203:
183:
165:
160:
144:
124:
112:
100:
88:
75:
63:
55:
50:
21:
853:, a homolog of the Drosophila clk gene, and the
641:involved in protein-protein interactions of the
1474:Annual Review of Cell and Developmental Biology
1771:
8:
864:The PAS domain also directly interacts with
1778:
1764:
1756:
157:
27:
1735:
1725:
1633:
1623:
1574:
1525:
1407:
1382:Möglich, A; Ayers, RA; Moffat, K (2009).
1358:
1300:
1259:
1210:
1161:
1120:
1110:
1066:
973:
1326:
1324:
1322:
1320:
1144:Ponting CP, Aravind L (November 1997).
1088:
1086:
881:
18:
1450:10.1146/annurev-physiol-021909-135922
1429:
1427:
7:
738:methyl-accepting chemotaxis proteins
1351:10.1146/annurev-micro-121809-151631
966:10.1146/annurev-micro-121809-151631
812:circadian-associated protein WC-1.
1289:European Journal of Human Genetics
868:. It is typically located on the
693:. These signals propagate via the
14:
1487:10.1146/annurev.cellbio.17.1.215
1212:10.1111/j.1432-1033.2004.04023.x
1000:Acta Crystallographica Section D
1606:Jones, Susan (1 January 2004).
845:and other small molecules like
1:
1527:10.1016/S0092-8674(00)80841-7
1338:Annual Review of Microbiology
1163:10.1016/S0960-9822(06)00352-6
953:Annual Review of Microbiology
161:Available protein structures:
1576:10.1016/j.neuron.2006.03.041
1112:10.1371/journal.pbio.1000094
711:Examples of PAS in organisms
1437:Annual Review of Physiology
857:(HIF) also help to mediate
2124:
801:
780:In the presence of light,
773:
756:In the presence of light,
749:
699:photoactive yellow protein
1793:
1400:10.1016/j.str.2009.08.011
1252:10.1016/j.str.2009.08.011
1059:10.1016/j.str.2009.08.011
1020:10.1107/S139900471501384X
836:Other mammalian PAS roles
156:
26:
855:hypoxia inducible factor
704:Halorhodospira halophila
659:period circadian protein
1727:10.1073/pnas.92.12.5510
1625:10.1186/gb-2004-5-6-226
1302:10.1038/sj.ejhg.5201547
849:, but PAS B domains in
734:cyclic-di-GMP syntheses
1671:10.1124/mol.106.027029
1659:Molecular Pharmacology
2108:Protein superfamilies
671:single-minded protein
736:and hydrolases, and
1718:1995PNAS...92.5510W
1012:2015AcCrD..71.2127L
2090:
2089:
1712:(12): 5510–5514.
1246:(10): 1282–1294.
1053:(10): 1282–1294.
1006:(10): 2127–2136.
917:10.1021/bi0343370
730:histidine kinases
717:pairwise sequence
618:
617:
614:
613:
210:structure summary
41:= red) while the
2115:
1780:
1773:
1766:
1757:
1750:
1749:
1739:
1729:
1697:
1691:
1690:
1665:(5): 1469–1480.
1654:
1648:
1647:
1637:
1627:
1603:
1597:
1596:
1578:
1554:
1548:
1547:
1529:
1505:
1499:
1498:
1468:
1462:
1461:
1431:
1422:
1421:
1411:
1379:
1373:
1372:
1362:
1328:
1315:
1314:
1304:
1280:
1274:
1273:
1263:
1231:
1225:
1224:
1214:
1190:
1184:
1183:
1165:
1141:
1135:
1134:
1124:
1114:
1090:
1081:
1080:
1070:
1038:
1032:
1031:
994:
988:
987:
977:
943:
937:
936:
896:
886:
639:structural motif
609:
603:
597:
591:
585:
579:
573:
567:
561:
555:
549:
543:
537:
531:
525:
519:
513:
507:
501:
495:
489:
483:
477:
471:
465:
459:
453:
447:
441:
435:
429:
423:
417:
411:
405:
399:
393:
387:
381:
375:
369:
363:
357:
351:
345:
339:
333:
327:
321:
315:
309:
303:
297:
291:
285:
279:
273:
267:
261:
255:
249:
243:
237:
231:
225:
158:
31:
19:
2123:
2122:
2118:
2117:
2116:
2114:
2113:
2112:
2093:
2092:
2091:
2086:
1789:
1787:Protein domains
1784:
1754:
1753:
1699:
1698:
1694:
1656:
1655:
1651:
1605:
1604:
1600:
1556:
1555:
1551:
1507:
1506:
1502:
1470:
1469:
1465:
1433:
1432:
1425:
1394:(10): 1282–94.
1381:
1380:
1376:
1330:
1329:
1318:
1282:
1281:
1277:
1233:
1232:
1228:
1205:(6): 1198–208.
1199:Eur. J. Biochem
1192:
1191:
1187:
1143:
1142:
1138:
1105:(4): e1000094.
1092:
1091:
1084:
1040:
1039:
1035:
996:
995:
991:
945:
944:
940:
898:
888:
887:
883:
878:
838:
818:
806:
800:
778:
772:
754:
748:
726:
713:
686:
651:
643:circadian clock
605:
599:
593:
587:
581:
575:
569:
563:
557:
551:
545:
539:
533:
527:
521:
515:
509:
503:
497:
491:
485:
479:
473:
467:
461:
455:
449:
443:
437:
431:
425:
419:
413:
407:
401:
395:
389:
383:
377:
371:
365:
359:
353:
347:
341:
335:
329:
323:
317:
311:
305:
299:
293:
287:
281:
275:
269:
263:
257:
251:
245:
239:
233:
227:
221:
46:
17:
12:
11:
5:
2121:
2119:
2111:
2110:
2105:
2095:
2094:
2088:
2087:
2085:
2084:
2079:
2074:
2069:
2064:
2059:
2054:
2049:
2044:
2039:
2034:
2029:
2028:
2027:
2017:
2012:
2007:
2002:
1997:
1992:
1987:
1982:
1977:
1972:
1967:
1962:
1957:
1952:
1947:
1942:
1941:
1940:
1935:
1930:
1925:
1915:
1910:
1905:
1900:
1895:
1890:
1885:
1880:
1875:
1870:
1865:
1860:
1855:
1850:
1845:
1840:
1835:
1830:
1825:
1820:
1815:
1810:
1805:
1800:
1794:
1791:
1790:
1785:
1783:
1782:
1775:
1768:
1760:
1752:
1751:
1692:
1649:
1612:Genome Biology
1598:
1549:
1520:(3): 319–329.
1500:
1463:
1423:
1374:
1316:
1295:(6): 729–738.
1275:
1226:
1185:
1156:(11): R674–7.
1136:
1082:
1033:
989:
938:
911:(25): 7701–8.
880:
879:
877:
874:
837:
834:
817:
814:
802:Main article:
799:
794:
774:Main article:
771:
766:
758:White Collar-1
750:Main article:
747:
742:
725:
722:
712:
709:
685:
682:
674:
673:
667:
661:
650:
647:
634:protein domain
616:
615:
612:
611:
219:
213:
212:
207:
201:
200:
187:
181:
180:
170:
163:
162:
154:
153:
148:
142:
141:
128:
122:
121:
116:
110:
109:
104:
98:
97:
92:
86:
85:
80:
73:
72:
67:
61:
60:
57:
53:
52:
48:
47:
32:
24:
23:
16:Protein domain
15:
13:
10:
9:
6:
4:
3:
2:
2120:
2109:
2106:
2104:
2101:
2100:
2098:
2083:
2080:
2078:
2075:
2073:
2070:
2068:
2065:
2063:
2060:
2058:
2055:
2053:
2050:
2048:
2045:
2043:
2040:
2038:
2035:
2033:
2030:
2026:
2023:
2022:
2021:
2018:
2016:
2013:
2011:
2008:
2006:
2003:
2001:
1998:
1996:
1993:
1991:
1988:
1986:
1983:
1981:
1978:
1976:
1973:
1971:
1968:
1966:
1963:
1961:
1958:
1956:
1953:
1951:
1948:
1946:
1943:
1939:
1936:
1934:
1931:
1929:
1926:
1924:
1921:
1920:
1919:
1916:
1914:
1911:
1909:
1906:
1904:
1901:
1899:
1896:
1894:
1891:
1889:
1886:
1884:
1881:
1879:
1876:
1874:
1871:
1869:
1866:
1864:
1861:
1859:
1856:
1854:
1851:
1849:
1846:
1844:
1841:
1839:
1836:
1834:
1831:
1829:
1826:
1824:
1821:
1819:
1816:
1814:
1811:
1809:
1806:
1804:
1801:
1799:
1796:
1795:
1792:
1788:
1781:
1776:
1774:
1769:
1767:
1762:
1761:
1758:
1747:
1743:
1738:
1733:
1728:
1723:
1719:
1715:
1711:
1707:
1703:
1696:
1693:
1688:
1684:
1680:
1676:
1672:
1668:
1664:
1660:
1653:
1650:
1645:
1641:
1636:
1631:
1626:
1621:
1617:
1613:
1609:
1602:
1599:
1594:
1590:
1586:
1582:
1577:
1572:
1569:(3): 465–77.
1568:
1564:
1560:
1553:
1550:
1545:
1541:
1537:
1533:
1528:
1523:
1519:
1515:
1511:
1504:
1501:
1496:
1492:
1488:
1484:
1480:
1476:
1475:
1467:
1464:
1459:
1455:
1451:
1447:
1443:
1439:
1438:
1430:
1428:
1424:
1419:
1415:
1410:
1405:
1401:
1397:
1393:
1389:
1385:
1378:
1375:
1370:
1366:
1361:
1356:
1352:
1348:
1344:
1340:
1339:
1334:
1327:
1325:
1323:
1321:
1317:
1312:
1308:
1303:
1298:
1294:
1290:
1286:
1279:
1276:
1271:
1267:
1262:
1257:
1253:
1249:
1245:
1241:
1237:
1230:
1227:
1222:
1218:
1213:
1208:
1204:
1200:
1196:
1189:
1186:
1181:
1177:
1173:
1169:
1164:
1159:
1155:
1151:
1147:
1140:
1137:
1132:
1128:
1123:
1118:
1113:
1108:
1104:
1100:
1096:
1089:
1087:
1083:
1078:
1074:
1069:
1064:
1060:
1056:
1052:
1048:
1044:
1037:
1034:
1029:
1025:
1021:
1017:
1013:
1009:
1005:
1001:
993:
990:
985:
981:
976:
971:
967:
963:
959:
955:
954:
949:
942:
939:
934:
930:
926:
922:
918:
914:
910:
906:
902:
895:
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672:
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2019:
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1435:
1391:
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1336:
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1229:
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1198:
1188:
1153:
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1139:
1102:
1099:PLOS Biology
1098:
1050:
1046:
1036:
1003:
999:
992:
957:
951:
941:
908:
905:Biochemistry
904:
884:
863:
839:
819:
809:
807:
796:
779:
768:
755:
744:
727:
714:
702:
687:
675:
652:
629:
625:
622:Per-Arnt-Sim
621:
619:
2082:zinc finger
1481:: 215–253.
1444:: 625–645.
1345:: 261–286.
960:: 261–286.
843:chaperonins
804:Arabidopsis
797:Arabidopsis
701:(PYP) from
689:within the
51:Identifiers
2103:PAS domain
2097:Categories
1618:(6): 226.
1150:Curr. Biol
876:References
870:C-Terminus
810:Neurospora
776:Drosophila
769:Drosophila
752:Neurospora
745:Neurospora
173:structures
39:C-terminus
35:N-terminus
1970:EcoEI_R_C
1388:Structure
1240:Structure
1047:Structure
897:;
695:α-helices
684:Structure
649:Discovery
604:,
598:,
592:,
586:,
580:,
574:,
568:,
562:,
556:,
550:,
544:,
538:,
532:,
526:,
520:,
514:,
508:,
502:,
496:,
490:,
484:,
478:,
472:,
466:,
460:,
454:,
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430:,
424:,
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322:,
316:,
310:,
304:,
298:,
292:,
286:,
280:,
274:,
268:,
262:,
256:,
250:,
244:,
238:,
232:,
226:,
119:PDOC50112
95:IPR013767
1679:16887934
1644:15186484
1593:19028601
1585:16675400
1536:10847686
1495:11687489
1458:20148691
1418:19836329
1369:21663441
1311:16721409
1270:19836329
1221:15009198
1180:14105830
1131:19402751
1077:19836329
1028:26457436
984:21663441
933:14090693
925:12820879
724:Bacteria
190:RCSB PDB
90:InterPro
37:= blue,
22:PAS fold
2000:Kringle
1893:CGI-121
1863:BTB/POZ
1746:7539918
1714:Bibcode
1687:2522614
1544:3013788
1409:3092527
1360:3298442
1261:3092527
1172:9382818
1122:2671562
1068:3092527
1008:Bibcode
975:3298442
830:CRY 1,2
816:Mammals
691:β-sheet
678:PAS LOV
663:Arnt –
610:
151:cd00130
114:PROSITE
70:PF00989
1744:
1734:
1685:
1677:
1642:
1635:463060
1632:
1591:
1583:
1563:Neuron
1542:
1534:
1493:
1456:
1416:
1406:
1367:
1357:
1309:
1268:
1258:
1219:
1178:
1170:
1129:
1119:
1075:
1065:
1026:
982:
972:
931:
923:
859:ligand
847:dioxin
669:Sim –
657:Per –
630:domain
205:PDBsum
179:
169:
139:SUPFAM
83:CL0183
56:Symbol
2015:NACHT
1938:Pyrin
1918:Death
1883:Cache
1818:ADF-H
1737:41725
1683:S2CID
1589:S2CID
1540:S2CID
1176:S2CID
929:S2CID
851:NPAS2
822:BMAL1
632:is a
135:SCOPe
126:SCOP2
102:SMART
2067:WD40
2062:TRIO
1995:HEAT
1990:FYVE
1985:FGGY
1980:ENTH
1960:DHR2
1955:DHR1
1950:DHHC
1933:CARD
1913:CVHN
1868:BZIP
1843:BESS
1828:ARID
1823:ANTH
1808:ACDC
1742:PMID
1675:PMID
1640:PMID
1581:PMID
1532:PMID
1514:Cell
1491:PMID
1454:PMID
1414:PMID
1365:PMID
1307:PMID
1266:PMID
1217:PMID
1168:PMID
1127:PMID
1073:PMID
1024:PMID
980:PMID
921:PMID
894:1y28
866:BHLH
824:and
784:and
607:3pyp
601:3phy
595:2pyr
589:2pyp
583:2phy
577:2d02
571:2d01
565:1y28
559:1xj6
553:1xj4
547:1xj3
541:1xj2
535:1xfq
529:1xfn
523:1wa9
517:1vb6
511:1v9z
505:1v9y
499:1uwp
493:1uwn
487:1ugu
481:1ts8
475:1ts7
469:1ts6
463:1ts0
457:1t1c
451:1t1b
445:1t1a
439:1t19
433:1t18
427:1s67
421:1s66
415:1s4s
409:1s4r
403:1s1z
397:1s1y
391:1oti
385:1ote
379:1otd
373:1otb
367:1ota
361:1ot9
355:1ot6
349:1odv
343:1nwz
337:1mzu
331:1lt0
325:1lsx
319:1lsw
313:1lsv
307:1ll8
301:1kou
295:1gsx
289:1gsw
283:1gsv
277:1f9i
271:1f98
265:1ew0
259:1drm
253:1dp9
247:1dp8
241:1dp6
235:1d7e
229:1d06
223:1byw
198:PDBj
194:PDBe
177:ECOD
167:Pfam
131:2phy
79:clan
77:Pfam
65:Pfam
43:heme
2077:YTH
2057:SUN
2052:SH3
2047:SH2
2032:PDZ
2025:LOV
2020:PAS
2010:LRR
2005:LIM
1975:EF1
1945:DEP
1928:DED
1908:CUT
1903:CUB
1898:CRM
1888:CBS
1858:BPS
1853:BMC
1848:BIR
1838:BEN
1833:BAR
1813:ACT
1803:ABM
1732:PMC
1722:doi
1667:doi
1630:PMC
1620:doi
1571:doi
1522:doi
1518:101
1483:doi
1446:doi
1404:PMC
1396:doi
1355:PMC
1347:doi
1297:doi
1256:PMC
1248:doi
1207:doi
1203:271
1158:doi
1117:PMC
1107:doi
1063:PMC
1055:doi
1016:doi
970:PMC
962:doi
913:doi
890:PDB
826:CLK
790:Tim
786:CYC
782:CLK
762:FRQ
626:PAS
217:PDB
185:PDB
146:CDD
107:PAS
59:PAS
2099::
2072:X8
2042:PX
2037:PH
1965:DM
1923:DD
1878:C2
1873:C1
1798:3H
1740:.
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1710:92
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