Knowledge (XXG)

DJ-1

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Bonifati V, Dekker MC, Vanacore N, Fabbrini G, Squitieri F, Marconi R, Antonini A, Brustenghi P, Dalla Libera A, De Mari M, Stocchi F, Montagna P, Gallai V, Rizzu P, van Swieten JC, Oostra B, van Duijn CM, Meco G, Heutink P (Sep 2002). "Autosomal recessive early onset parkinsonism is linked to three
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Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, Heutink P (Jan 2003). "Mutations in the DJ-1 gene associated with autosomal recessive early-onset
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Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SM, Ariga H (Feb 2003). "DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex".
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has been reported for decades. Recently evidence has been presented that defective DNA repair is linked specifically to DJ-1 mutation, and thus DJ-1 mutation likely contributes to Parkinson's disease pathogenesis.
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Dekker M, Bonifati V, van Swieten J, Leenders N, Galjaard RJ, Snijders P, Horstink M, Heutink P, Oostra B, van Duijn C (Jul 2003). "Clinical features and neuroimaging of PARK7-linked parkinsonism".
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Nunome K, Miyazaki S, Nakano M, Iguchi-Ariga S, Ariga H (Jul 2008). "Pyrroloquinoline quinone prevents oxidative stress-induced neuronal death probably through changes in oxidative status of DJ-1".
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Taira T, Takahashi K, Kitagawa R, Iguchi-Ariga SM, Ariga H (Jan 2001). "Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter".
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van Duijn CM, Dekker MC, Bonifati V, Galjaard RJ, Houwing-Duistermaat JJ, Snijders PJ, Testers L, Breedveld GJ, Horstink M, Sandkuijl LA, van Swieten JC, Oostra BA, Heutink P (Sep 2001).
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Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H (Feb 1997). "DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras".
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Miller DW, Ahmad R, Hague S, Baptista MJ, Canet-Aviles R, McLendon C, Carter DM, Zhu PP, Stadler J, Chandran J, Klinefelter GR, Blackstone C, Cookson MR (Sep 2003).
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Bonifati V, Oostra BA, Heutink P (Mar 2004). "Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease".
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Martín-Nieto J, Uribe ML, Esteve-Rudd J, Herrero MT, Campello L (August 2019). "A role for DJ-1 against oxidative stress in the mammalian retina".
2002:. Accordingly, DJ-1 apparently protects neurons against oxidative stress and cell death. In parallel, protein DJ-1 acts as a positive regulator of 2161: 2477:
Zhou W, Zhu M, Wilson MA, Petsko GA, Fink AL (Mar 2006). "The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein".
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Richarme G, Liu C, Mihoub M, Abdallah J, Leger T, Joly N, Liebart JC, Jurkunas UV, Nadal M, Bouloc P, Dairou J, Lamouri A (July 2017).
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of mammals, where it exerts a neuroprotective role against oxidative stress under both physiological and pathological conditions.
2085: 2219: 2198: 3718: 2215: 371: 346: 63: 2194: 3598: 3583: 288: 3688: 2129: 3480:"L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system" 485: 384: 2093: 2016:(PQQ) has been shown to reduce the self-oxidation of the DJ-1 protein, an early step in the onset of some forms of 2007: 3658: 478: 377: 3556: 2097: 2013: 1662: 296: 3230:
Lev N, Roncevic D, Roncevich D, Ickowicz D, Melamed E, Offen D (2007). "Role of DJ-1 in Parkinson's disease".
2387:"Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain" 2669:
Björkblom B, Adilbayeva A, Maple-Grødem J, Piston D, Ökvist M, Xu XM, Brede C, Larsen JP, Møller SG (2013).
1643: 2114: 2101: 2072:. Deglycase-deficient bacterial mutants with reduced ability to repair glycated bases in DNA show strong 2023:
Functional DJ-1 protein has been shown to bind metals and protect against metal-induced cytotoxicity from
2017: 3370:"DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor" 2963:"DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor" 3549: 2840: 2738: 2578: 360: 275: 2385:
Lee SJ, Kim SJ, Kim IK, Ko J, Jeong CS, Kim GH, Park C, Kang SO, Suh PG, Lee HS, Cha SS (Nov 2003).
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negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
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Abou-Sleiman PM, Healy DG, Wood NW (Oct 2004). "Causes of Parkinson's disease: genetics of DJ-1".
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Wang ZX, Liu Y, Li YL, Wei Q, Lin RR, Kang R, Ruan Y, Lin ZH, Xue NJ, Zhang BR, Pu JL (May 2023).
3466: 3429: 3255: 3140: 3074: 3037: 2864: 2547: 2428:"DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation" 1208:
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
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via its chaperone activity, thus functioning as a redox-sensitive chaperone and as a sensor for
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Heutink P (2006). "PINK-1 and DJ-1 — new genes for autosomal recessive Parkinson's disease".
2884:"Neuron-specific protein interactions of Drosophila CASK-β are revealed by mass spectrometry" 2671:"Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity" 1173:
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
3712:: The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease 3491: 3450: 3413: 3381: 3346: 3338: 3305: 3276: 3239: 3200: 3173: 3165: 3124: 3095: 3058: 3019: 2974: 2905: 2895: 2848: 2802: 2792: 2746: 2692: 2682: 2641: 2633: 2596: 2586: 2529: 2521: 2486: 2449: 2439: 2398: 2357: 2346:"Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease" 2316: 2305:"The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease" 1999: 1975: 1188:
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
565: 496: 440: 395: 3327:"Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36" 723: 316: 540: 2844: 2807: 2780: 2742: 2582: 3351: 3326: 2910: 2883: 2697: 2670: 2601: 2567:"DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE)" 2566: 2171: 2088:
response protein that is recruited to sites of DNA damage where it participates in the
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negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
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positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
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Honbou K, Suzuki NN, Horiuchi M, Niki T, Taira T, Ariga H, Inagaki F (Aug 2003).
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Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of
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National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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negative regulation of proteasomal ubiquitin-dependent protein catabolic process
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Le W, Appel SH (Feb 2004). "Mutant genes responsible for Parkinson's disease".
2781:"Nuclear DJ-1 Regulates DNA Damage Repair via the Regulation of PARP1 Activity" 2056:, either in the form of a free nucleotide or as a nucleotide incorporated into 641: 3682:: Crystal structure of DJ-1/RS and implication on familial Parkinson's disease 3128: 3062: 2490: 2089: 2049: 457: 354: 304: 3199:. Journal of Neural Transmission. Supplementa. Vol. 70. pp. 215–9. 2900: 3368:
Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H (Oct 2001).
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Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H (Oct 2001).
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positive regulation of mitochondrial electron transport, NADH to ubiquinone
3417: 3288: 2006:-dependent transcription. DJ-1 is expressed in both the neural retina and 1872: 1867: 2797: 2289: 1856: 1707: 1688: 2637: 1483:
positive regulation of acute inflammatory response to antigenic stimulus
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Shendelman S, Jonason A, Martinat C, Leete T, Abeliovich A (Nov 2004).
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Defects in this gene are the cause of autosomal recessive early-onset
245: 241: 237: 233: 229: 225: 221: 217: 213: 209: 205: 201: 197: 193: 189: 185: 181: 177: 173: 169: 165: 161: 157: 153: 149: 145: 141: 137: 133: 129: 125: 121: 117: 113: 109: 105: 101: 97: 93: 89: 85: 2142: 2024: 1916: 1840: 1584: 17: 3342: 2727:"Guanine glycation repair by DJ-1/Park7 and its bacterial homologs" 1533:
negative regulation of reactive oxygen species biosynthetic process
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positive regulation of oxidative phosphorylation uncoupler activity
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positive regulation of reactive oxygen species biosynthetic process
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negative regulation of TRAIL-activated apoptotic signaling pathway
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positive regulation of transcription regulatory region DNA binding
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positive regulation of pyrroline-5-carboxylate reductase activity
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negative regulation of death-inducing signaling complex assembly
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positive regulation of DNA-binding transcription factor activity
732: 292: 279:, DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD2 3545: 3541: 2065: 2061: 2038:
and its bacterial homologs: Hsp31, YhbO, and YajL can repair
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negative regulation of ubiquitin-protein transferase activity
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negative regulation of hydrogen peroxide-induced neuron death
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Overview of all the structural information available in the
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Mukherjee K, Slawson JB, Christmann BL, Griffith LC (2014).
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negative regulation of oxidative stress-induced neuron death
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negative regulation of extrinsic apoptotic signaling pathway
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Shadrach KG, Rayborn ME, Hollyfield JG, Bonilha VL (2013).
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negative regulation of ubiquitin-specific protease activity
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negative regulation of hydrogen peroxide-induced cell death
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negative regulation of protein K48-linked deubiquitination
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negative regulation of oxidative stress-induced cell death
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positive regulation of transcription by RNA polymerase II
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positive regulation of tyrosine 3-monooxygenase activity
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positive regulation of protein homodimerization activity
548: 3637:: Crystal structure of human DJ-1, P 1 21 1 space group 3622:: Crystal structure of human DJ-1, P 31 2 1 space group 871:
oxidoreductase activity, acting on peroxide as acceptor
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positive regulation of protein localization to nucleus
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positive regulation of peptidyl-serine phosphorylation
3652:: Crystal structure of the K130R mutant of human DJ-1 713: 1318:
positive regulation of dopamine biosynthetic process
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positive regulation of superoxide dismutase activity
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positive regulation of L-dopa decarboxylase activity
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Biochemical and Biophysical Research Communications
1954:in size and composed of 189 amino acids with seven 1801: 1776: 1750: 1725: 2211: 2209: 2207: 2190: 2188: 2186: 1393:negative regulation of protein export from nucleus 1328:positive regulation of L-dopa biosynthetic process 1413:positive regulation of androgen receptor activity 1298:positive regulation of autophagy of mitochondrion 1288:regulation of androgen receptor signaling pathway 1263:dopamine uptake involved in synaptic transmission 1113:positive regulation of protein kinase B signaling 836:ubiquitin-like protein conjugating enzyme binding 495: 394: 2100:. Evidence for a linkage between DNA damage and 1118:negative regulation of protein catabolic process 2720: 2718: 2716: 1493:positive regulation of NAD(P)H oxidase activity 1193:regulation of supramolecular fiber organization 1078:positive regulation of interleukin-8 production 1048:negative regulation of neuron apoptotic process 2216:GRCm38: Ensembl release 89: ENSMUSG00000028964 1973:The protein structures of human protein DJ-1, 1373:regulation of mitochondrial membrane potential 1213:negative regulation of protein kinase activity 1203:negative regulation of protein phosphorylation 881:superoxide dismutase copper chaperone activity 3557: 3534:(Protein/nucleic acid deglycase DJ-1) at the 1378:negative regulation of protein ubiquitination 8: 1368:cellular response to reactive oxygen species 2774: 2772: 2770: 2195:GRCh38: Ensembl release 89: ENSG00000116288 801:tyrosine 3-monooxygenase activator activity 3741:United States National Library of Medicine 3564: 3550: 3542: 1558: 1523:guanine deglycation, methylglyoxal removal 1463:protein deglycation, methylglyoxal removal 1098:negative regulation of protein acetylation 1058:negative regulation of protein sumoylation 748: 536: 435: 332: 74: 3495: 3385: 3350: 3197:Parkinson's Disease and Related Disorders 3177: 3023: 2978: 2909: 2899: 2806: 2796: 2750: 2696: 2686: 2645: 2600: 2590: 2533: 2453: 2443: 2402: 2361: 2320: 972:mitochondrial respiratory chain complex I 3739:This article incorporates text from the 2626:Biological & Pharmaceutical Bulletin 2270: 2268: 2266: 2264: 2068:), if glycated, can be repaired by DJ-1/ 1942:and locates at chromosome band 1p36.23. 1503:cellular response to DNA damage stimulus 1248:negative regulation of apoptotic process 614:Skeletal muscle tissue of biceps brachii 3579: 2182: 1986:protease are evolutionarily conserved. 1950:The human protein deglycase DJ-1 is 20 1333:activation of protein kinase B activity 826:small protein activating enzyme binding 786:L-dopa decarboxylase activator activity 1428:cellular response to hydrogen peroxide 1388:positive regulation of gene expression 1153:negative regulation of gene expression 1128:regulation of neuron apoptotic process 1068:negative regulation of protein binding 29: 3727:: Pre-oxidation Complex of Human DJ-1 1408:cellular response to oxidative stress 500: 461: 456: 399: 358: 353: 7: 2162:Animal models of Parkinson's disease 1528:guanine deglycation, glyoxal removal 1458:protein deglycation, glyoxal removal 3484:The Journal of Biological Chemistry 3374:The Journal of Biological Chemistry 2967:The Journal of Biological Chemistry 2888:Frontiers in Molecular Neuroscience 2391:The Journal of Biological Chemistry 2350:The Journal of Biological Chemistry 2309:The Journal of Biological Chemistry 1383:hydrogen peroxide metabolic process 1283:regulation of inflammatory response 1198:negative regulation of neuron death 1073:synaptic transmission, dopaminergic 896:ubiquitin-specific protease binding 664:medial head of gastrocnemius muscle 606:dorsal motor nucleus of vagus nerve 27:Protein-coding gene found in humans 3331:American Journal of Human Genetics 2090:repair of DNA double-strand breaks 1895:which in humans is encoded by the 1798: 1773: 1747: 1722: 1698: 1679: 1653: 1634: 1608: 1589: 921:protein-containing complex binding 866:transcription coactivator activity 718: 636: 574: 553: 25: 3607:: Crystal Structure of Human DJ-1 3592:: Crystal Structure of Human DJ-1 3232:Journal of Molecular Neuroscience 3152:Pankratz N, Foroud T (Apr 2004). 2167:Mitochondria associated membranes 1138:negative regulation of cell death 952:mitochondrial intermembrane space 816:protein homodimerization activity 3717: 3702: 3687: 3672: 3657: 3642: 3627: 3612: 3597: 3582: 3404:loci: PARK2, PARK6, and PARK7". 722: 688:extensor digitorum longus muscle 484: 477: 471: 448: 383: 376: 370: 345: 38: 3697:: Human DJ-1 with sulfinic acid 3154:"Genetics of Parkinson disease" 3088:Current Opinion in Pharmacology 2675:Journal of Biological Chemistry 2290:"Uniprot: Q99497 - PARK7_HUMAN" 1433:methylglyoxal metabolic process 1353:cellular oxidant detoxification 1088:Ras protein signal transduction 1022:perinuclear region of cytoplasm 1143:glycolate biosynthetic process 733:More reference expression data 702:More reference expression data 1: 3310:10.1016/S0378-1119(00)00590-4 3051:Journal of Molecular Medicine 3025:10.1016/S0896-6273(02)01166-2 1982:Hsp31, YhbO, and YajL and an 1962:in total and is present as a 1448:peptidyl-arginine deglycation 1443:peptidyl-cysteine deglycation 1343:detoxification of mercury ion 1303:response to hydrogen peroxide 469: 368: 3205:10.1007/978-3-211-45295-0_33 2592:10.1371/journal.pone.0067983 2526:10.1016/j.neulet.2019.134361 2479:Journal of Molecular Biology 2445:10.1371/journal.pbio.0020362 1438:lactate biosynthetic process 1308:detoxification of copper ion 1093:cellular response to glyoxal 781:transcription factor binding 602:Epithelium of choroid plexus 3761:Genes on human chromosome 1 3667:: crystal structure of DJ-1 1930:, encodes a protein of the 1889:Parkinson disease protein 7 1453:peptidyl-lysine deglycation 851:double-stranded DNA binding 831:single-stranded DNA binding 3777: 3100:10.1016/j.coph.2003.09.005 3008:"Pathways to Parkinsonism" 2344:Tao X, Tong L (Aug 2003). 2094:non-homologous end joining 2008:retinal pigment epithelium 1914: 1338:membrane hyperpolarization 1233:mitochondrion organization 916:protein deglycase activity 766:signaling receptor binding 676:retinal pigment epithelium 3577: 3129:10.1007/s00441-004-0922-6 3063:10.1007/s00109-003-0512-1 2936:Molecular Cancer Research 2491:10.1016/j.jmb.2005.12.030 2251:"Mouse PubMed Reference:" 2233:"Human PubMed Reference:" 2092:through the processes of 1871: 1866: 1862: 1855: 1839: 1820: 1805: 1780: 1769: 1754: 1729: 1718: 1705: 1701: 1686: 1682: 1673: 1660: 1656: 1641: 1637: 1628: 1615: 1611: 1596: 1592: 1583: 1568: 1561: 1557: 1541: 1473:glyoxal metabolic process 1123:adult locomotory behavior 891:identical protein binding 876:androgen receptor binding 751: 747: 730: 721: 712: 699: 648: 639: 586: 577: 547: 539: 535: 518: 505: 468: 447: 438: 434: 417: 404: 367: 344: 335: 331: 286: 283: 273: 266: 261: 82: 77: 60: 55: 50: 46: 37: 32: 3117:Cell and Tissue Research 2901:10.3389/fnmol.2014.00058 2098:homologous recombination 2014:Pyrroloquinoline quinone 1970:C56 family of proteins. 821:scaffold protein binding 672:tibialis anterior muscle 610:tibialis anterior muscle 3170:10.1602/neurorx.1.2.235 3006:Cookson MR (Jan 2003). 2853:10.1126/science.1077209 2752:10.1126/science.aag1095 2688:10.1074/jbc.M113.482091 1934:family. The human gene 1488:protein deglycosylation 1468:glutathione deglycation 1223:membrane depolarization 656:vastus lateralis muscle 622:vastus lateralis muscle 3497:10.1074/jbc.M304272200 3387:10.1074/jbc.M101730200 3281:10.1006/bbrc.1997.6132 2980:10.1074/jbc.M101730200 2404:10.1074/jbc.M304517200 2363:10.1074/jbc.M304221200 2322:10.1074/jbc.M305878200 1885:Protein deglycase DJ-1 1833:Chr 4: 150.98 – 151 Mb 846:peroxiredoxin activity 652:triceps brachii muscle 3418:10.1007/s100720200069 3406:Neurological Sciences 2109:Clinical significance 1966:. It belongs to the 1826:Chr 1: 7.95 – 7.99 Mb 1228:protein stabilization 1183:inflammatory response 992:extracellular exosome 977:endoplasmic reticulum 3244:10.1385/JMN:29:3:215 2798:10.3390/ijms24108651 2276:"Entrez Gene: PARK7" 1158:single fertilization 1002:mitochondrial matrix 668:facial motor nucleus 660:gastrocnemius muscle 463:Chromosome 4 (mouse) 361:Chromosome 1 (human) 78:List of PDB id codes 51:Available structures 3412:(Suppl 2): S59-60. 2845:2003Sci...299..256B 2743:2017Sci...357..208R 2638:10.1248/bpb.31.1321 2583:2013PLoSO...867983S 2115:Parkinson's disease 2102:Parkinson's disease 2018:Parkinson's disease 1518:guanine deglycation 1513:glucose homeostasis 906:cuprous ion binding 861:mercury ion binding 618:islet of Langerhans 3743:, which is in the 3443:Movement Disorders 2128:has been shown to 2074:mutator phenotypes 1663:ENSMUSG00000028964 1041:Biological process 930:Cellular component 901:hydrolase activity 856:copper ion binding 791:peptidase activity 776:cupric ion binding 759:Molecular function 3735: 3734: 3455:10.1002/mds.10422 3214:978-3-211-28927-3 2737:(6347): 208–211. 2004:androgen receptor 1882: 1881: 1878: 1877: 1851: 1850: 1816: 1815: 1795: 1794: 1765: 1764: 1744: 1743: 1714: 1713: 1695: 1694: 1669: 1668: 1650: 1649: 1624: 1623: 1605: 1604: 1553: 1552: 1508:insulin secretion 962:neuron projection 743: 742: 739: 738: 708: 707: 695: 694: 633: 632: 531: 530: 430: 429: 325:PARK7 - orthologs 257: 256: 253: 252: 61:Ortholog search: 16:(Redirected from 3768: 3721: 3706: 3691: 3676: 3661: 3646: 3631: 3616: 3601: 3586: 3566: 3559: 3552: 3543: 3509: 3499: 3490:(38): 36588–95. 3474: 3437: 3399: 3389: 3380:(40): 37556–63. 3364: 3354: 3321: 3292: 3263: 3226: 3191: 3181: 3148: 3111: 3082: 3045: 3027: 2993: 2992: 2982: 2973:(40): 37556–63. 2958: 2952: 2951: 2930: 2924: 2923: 2913: 2903: 2879: 2873: 2872: 2827: 2821: 2820: 2810: 2800: 2776: 2765: 2764: 2754: 2722: 2711: 2710: 2700: 2690: 2681:(31): 22809–20. 2666: 2660: 2659: 2649: 2621: 2615: 2614: 2604: 2594: 2562: 2556: 2555: 2537: 2509: 2503: 2502: 2474: 2468: 2467: 2457: 2447: 2423: 2417: 2416: 2406: 2382: 2376: 2375: 2365: 2341: 2335: 2334: 2324: 2300: 2294: 2293: 2286: 2280: 2279: 2272: 2259: 2258: 2247: 2241: 2240: 2229: 2223: 2213: 2202: 2192: 2000:oxidative stress 1976:Escherichia coli 1926:, also known as 1887:, also known as 1864: 1863: 1835: 1828: 1811: 1799: 1790: 1774: 1770:RefSeq (protein) 1760: 1748: 1739: 1723: 1699: 1680: 1654: 1635: 1609: 1590: 1559: 911:cadherin binding 771:cytokine binding 749: 735: 726: 719: 704: 644: 642:Top expressed in 637: 598:endothelial cell 582: 580:Top expressed in 575: 554: 537: 527: 514: 503: 488: 481: 475: 464: 452: 436: 426: 413: 402: 387: 380: 374: 363: 349: 333: 327: 278: 271: 248: 75: 69: 48: 47: 42: 30: 21: 3776: 3775: 3771: 3770: 3769: 3767: 3766: 3765: 3751: 3750: 3736: 3731: 3728: 3722: 3713: 3707: 3698: 3692: 3683: 3677: 3668: 3662: 3653: 3647: 3638: 3632: 3623: 3617: 3608: 3602: 3593: 3587: 3573: 3570: 3517: 3512: 3477: 3440: 3402: 3367: 3324: 3304:(1–2): 285–92. 3295: 3266: 3229: 3215: 3194: 3151: 3114: 3085: 3048: 3005: 3001: 2999:Further reading 2996: 2960: 2959: 2955: 2932: 2931: 2927: 2881: 2880: 2876: 2839:(5604): 256–9. 2831:parkinsonism". 2829: 2828: 2824: 2778: 2777: 2768: 2724: 2723: 2714: 2668: 2667: 2663: 2623: 2622: 2618: 2564: 2563: 2559: 2511: 2510: 2506: 2476: 2475: 2471: 2425: 2424: 2420: 2397:(45): 44552–9. 2384: 2383: 2379: 2356:(33): 31372–9. 2343: 2342: 2338: 2315:(33): 31380–4. 2302: 2301: 2297: 2288: 2287: 2283: 2274: 2273: 2262: 2249: 2248: 2244: 2231: 2230: 2226: 2214: 2205: 2193: 2184: 2180: 2158: 2123: 2111: 2082: 1992: 1948: 1920: 1913: 1908: 1873:View/Edit Mouse 1868:View/Edit Human 1831: 1824: 1821:Location (UCSC) 1807: 1786: 1782: 1756: 1735: 1731: 1644:ENSG00000116288 1537: 1036: 997:plasma membrane 925: 841:protein binding 731: 700: 691: 686: 684:temporal muscle 682: 678: 674: 670: 666: 662: 658: 654: 640: 629: 626:right ventricle 624: 620: 616: 612: 608: 604: 600: 596: 592: 578: 522: 509: 501: 491: 490: 489: 482: 462: 439:Gene location ( 421: 408: 400: 390: 389: 388: 381: 359: 336:Gene location ( 287: 274: 267: 84: 62: 28: 23: 22: 15: 12: 11: 5: 3774: 3772: 3764: 3763: 3753: 3752: 3733: 3732: 3730: 3729: 3723: 3716: 3714: 3708: 3701: 3699: 3693: 3686: 3684: 3678: 3671: 3669: 3663: 3656: 3654: 3648: 3641: 3639: 3633: 3626: 3624: 3618: 3611: 3609: 3603: 3596: 3594: 3588: 3581: 3578: 3575: 3574: 3571: 3569: 3568: 3561: 3554: 3546: 3540: 3539: 3516: 3515:External links 3513: 3511: 3510: 3475: 3438: 3400: 3365: 3343:10.1086/322996 3322: 3293: 3264: 3227: 3213: 3192: 3149: 3112: 3083: 3046: 3002: 3000: 2997: 2995: 2994: 2953: 2925: 2874: 2822: 2766: 2712: 2661: 2616: 2557: 2504: 2485:(4): 1036–48. 2469: 2418: 2377: 2336: 2295: 2281: 2260: 2242: 2224: 2203: 2181: 2179: 2176: 2175: 2174: 2172:Stress granule 2169: 2164: 2157: 2154: 2153: 2152: 2146: 2140: 2122: 2119: 2110: 2107: 2081: 2078: 1991: 1988: 1947: 1944: 1912: 1909: 1907: 1904: 1880: 1879: 1876: 1875: 1870: 1860: 1859: 1853: 1852: 1849: 1848: 1846: 1844: 1837: 1836: 1829: 1822: 1818: 1817: 1814: 1813: 1803: 1802: 1796: 1793: 1792: 1778: 1777: 1771: 1767: 1766: 1763: 1762: 1752: 1751: 1745: 1742: 1741: 1727: 1726: 1720: 1716: 1715: 1712: 1711: 1703: 1702: 1696: 1693: 1692: 1684: 1683: 1677: 1671: 1670: 1667: 1666: 1658: 1657: 1651: 1648: 1647: 1639: 1638: 1632: 1626: 1625: 1622: 1621: 1613: 1612: 1606: 1603: 1602: 1594: 1593: 1587: 1581: 1580: 1575: 1570: 1566: 1565: 1555: 1554: 1551: 1550: 1539: 1538: 1536: 1535: 1530: 1525: 1520: 1515: 1510: 1505: 1500: 1495: 1490: 1485: 1480: 1475: 1470: 1465: 1460: 1455: 1450: 1445: 1440: 1435: 1430: 1425: 1420: 1415: 1410: 1405: 1400: 1395: 1390: 1385: 1380: 1375: 1370: 1365: 1360: 1355: 1350: 1345: 1340: 1335: 1330: 1325: 1320: 1315: 1310: 1305: 1300: 1295: 1290: 1285: 1280: 1275: 1270: 1265: 1260: 1255: 1250: 1245: 1240: 1235: 1230: 1225: 1220: 1215: 1210: 1205: 1200: 1195: 1190: 1185: 1180: 1175: 1170: 1165: 1160: 1155: 1150: 1145: 1140: 1135: 1130: 1125: 1120: 1115: 1110: 1105: 1100: 1095: 1090: 1085: 1080: 1075: 1070: 1065: 1060: 1055: 1050: 1044: 1042: 1038: 1037: 1035: 1034: 1029: 1024: 1019: 1014: 1009: 1004: 999: 994: 989: 984: 979: 974: 969: 964: 959: 954: 949: 944: 939: 933: 931: 927: 926: 924: 923: 918: 913: 908: 903: 898: 893: 888: 883: 878: 873: 868: 863: 858: 853: 848: 843: 838: 833: 828: 823: 818: 813: 808: 806:enzyme binding 803: 798: 796:kinase binding 793: 788: 783: 778: 773: 768: 762: 760: 756: 755: 745: 744: 741: 740: 737: 736: 728: 727: 716: 710: 709: 706: 705: 697: 696: 693: 692: 690: 689: 685: 681: 677: 673: 669: 665: 661: 657: 653: 649: 646: 645: 634: 631: 630: 628: 627: 623: 619: 615: 611: 607: 603: 599: 595: 594:deltoid muscle 591: 587: 584: 583: 571: 570: 562: 551: 545: 544: 541:RNA expression 533: 532: 529: 528: 520: 516: 515: 507: 504: 499: 493: 492: 483: 476: 470: 466: 465: 460: 454: 453: 445: 444: 432: 431: 428: 427: 419: 415: 414: 406: 403: 398: 392: 391: 382: 375: 369: 365: 364: 357: 351: 350: 342: 341: 329: 328: 285: 281: 280: 272: 264: 263: 259: 258: 255: 254: 251: 250: 80: 79: 71: 70: 59: 53: 52: 44: 43: 35: 34: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 3773: 3762: 3759: 3758: 3756: 3749: 3748: 3746: 3745:public domain 3742: 3726: 3720: 3715: 3711: 3705: 3700: 3696: 3690: 3685: 3681: 3675: 3670: 3666: 3660: 3655: 3651: 3645: 3640: 3636: 3630: 3625: 3621: 3615: 3610: 3606: 3600: 3595: 3591: 3585: 3580: 3576: 3567: 3562: 3560: 3555: 3553: 3548: 3547: 3544: 3537: 3533: 3532: 3527: 3523: 3519: 3518: 3514: 3507: 3503: 3498: 3493: 3489: 3485: 3481: 3476: 3472: 3468: 3464: 3460: 3456: 3452: 3448: 3444: 3439: 3435: 3431: 3427: 3423: 3419: 3415: 3411: 3407: 3401: 3397: 3393: 3388: 3383: 3379: 3375: 3371: 3366: 3362: 3358: 3353: 3348: 3344: 3340: 3337:(3): 629–34. 3336: 3332: 3328: 3323: 3319: 3315: 3311: 3307: 3303: 3299: 3294: 3290: 3286: 3282: 3278: 3275:(2): 509–13. 3274: 3270: 3265: 3261: 3257: 3253: 3249: 3245: 3241: 3238:(3): 215–25. 3237: 3233: 3228: 3224: 3220: 3216: 3210: 3206: 3202: 3198: 3193: 3189: 3185: 3180: 3175: 3171: 3167: 3164:(2): 235–42. 3163: 3159: 3155: 3150: 3146: 3142: 3138: 3134: 3130: 3126: 3122: 3118: 3113: 3109: 3105: 3101: 3097: 3093: 3089: 3084: 3080: 3076: 3072: 3068: 3064: 3060: 3057:(3): 163–74. 3056: 3052: 3047: 3043: 3039: 3035: 3031: 3026: 3021: 3017: 3013: 3009: 3004: 3003: 2998: 2990: 2986: 2981: 2976: 2972: 2968: 2964: 2957: 2954: 2949: 2945: 2942:(4): 247–61. 2941: 2937: 2929: 2926: 2921: 2917: 2912: 2907: 2902: 2897: 2893: 2889: 2885: 2878: 2875: 2870: 2866: 2862: 2858: 2854: 2850: 2846: 2842: 2838: 2834: 2826: 2823: 2818: 2814: 2809: 2804: 2799: 2794: 2790: 2786: 2785:Int J Mol Sci 2782: 2775: 2773: 2771: 2767: 2762: 2758: 2753: 2748: 2744: 2740: 2736: 2732: 2728: 2721: 2719: 2717: 2713: 2708: 2704: 2699: 2694: 2689: 2684: 2680: 2676: 2672: 2665: 2662: 2657: 2653: 2648: 2643: 2639: 2635: 2632:(7): 1321–6. 2631: 2627: 2620: 2617: 2612: 2608: 2603: 2598: 2593: 2588: 2584: 2580: 2577:(7): e67983. 2576: 2572: 2568: 2561: 2558: 2553: 2549: 2545: 2541: 2536: 2531: 2527: 2523: 2519: 2515: 2514:Neurosci Lett 2508: 2505: 2500: 2496: 2492: 2488: 2484: 2480: 2473: 2470: 2465: 2461: 2456: 2451: 2446: 2441: 2437: 2433: 2429: 2422: 2419: 2414: 2410: 2405: 2400: 2396: 2392: 2388: 2381: 2378: 2373: 2369: 2364: 2359: 2355: 2351: 2347: 2340: 2337: 2332: 2328: 2323: 2318: 2314: 2310: 2306: 2299: 2296: 2291: 2285: 2282: 2277: 2271: 2269: 2267: 2265: 2261: 2256: 2252: 2246: 2243: 2238: 2234: 2228: 2225: 2221: 2217: 2212: 2210: 2208: 2204: 2200: 2196: 2191: 2189: 2187: 2183: 2177: 2173: 2170: 2168: 2165: 2163: 2160: 2159: 2155: 2150: 2147: 2144: 2141: 2138: 2135: 2134: 2133: 2131: 2127: 2120: 2118: 2116: 2108: 2106: 2103: 2099: 2095: 2091: 2087: 2079: 2077: 2075: 2071: 2067: 2063: 2059: 2055: 2051: 2048: 2045: 2041: 2040:methylglyoxal 2037: 2032: 2030: 2026: 2021: 2019: 2015: 2011: 2009: 2005: 2001: 1997: 1989: 1987: 1985: 1981: 1978: 1977: 1971: 1969: 1965: 1961: 1957: 1953: 1945: 1943: 1941: 1937: 1933: 1932:peptidase C56 1929: 1925: 1918: 1915:For C56, see 1910: 1905: 1903: 1901: 1898: 1894: 1890: 1886: 1874: 1869: 1865: 1861: 1858: 1854: 1847: 1845: 1842: 1838: 1834: 1830: 1827: 1823: 1819: 1812: 1810: 1804: 1800: 1797: 1791: 1789: 1785: 1779: 1775: 1772: 1768: 1761: 1759: 1753: 1749: 1746: 1740: 1738: 1734: 1728: 1724: 1721: 1719:RefSeq (mRNA) 1717: 1710: 1709: 1704: 1700: 1697: 1691: 1690: 1685: 1681: 1678: 1676: 1672: 1665: 1664: 1659: 1655: 1652: 1646: 1645: 1640: 1636: 1633: 1631: 1627: 1620: 1619: 1614: 1610: 1607: 1601: 1600: 1595: 1591: 1588: 1586: 1582: 1579: 1576: 1574: 1571: 1567: 1564: 1560: 1556: 1549: 1545: 1540: 1534: 1531: 1529: 1526: 1524: 1521: 1519: 1516: 1514: 1511: 1509: 1506: 1504: 1501: 1499: 1496: 1494: 1491: 1489: 1486: 1484: 1481: 1479: 1476: 1474: 1471: 1469: 1466: 1464: 1461: 1459: 1456: 1454: 1451: 1449: 1446: 1444: 1441: 1439: 1436: 1434: 1431: 1429: 1426: 1424: 1421: 1419: 1416: 1414: 1411: 1409: 1406: 1404: 1401: 1399: 1396: 1394: 1391: 1389: 1386: 1384: 1381: 1379: 1376: 1374: 1371: 1369: 1366: 1364: 1361: 1359: 1356: 1354: 1351: 1349: 1346: 1344: 1341: 1339: 1336: 1334: 1331: 1329: 1326: 1324: 1321: 1319: 1316: 1314: 1311: 1309: 1306: 1304: 1301: 1299: 1296: 1294: 1291: 1289: 1286: 1284: 1281: 1279: 1276: 1274: 1271: 1269: 1266: 1264: 1261: 1259: 1256: 1254: 1251: 1249: 1246: 1244: 1241: 1239: 1236: 1234: 1231: 1229: 1226: 1224: 1221: 1219: 1216: 1214: 1211: 1209: 1206: 1204: 1201: 1199: 1196: 1194: 1191: 1189: 1186: 1184: 1181: 1179: 1176: 1174: 1171: 1169: 1166: 1164: 1161: 1159: 1156: 1154: 1151: 1149: 1146: 1144: 1141: 1139: 1136: 1134: 1131: 1129: 1126: 1124: 1121: 1119: 1116: 1114: 1111: 1109: 1106: 1104: 1101: 1099: 1096: 1094: 1091: 1089: 1086: 1084: 1081: 1079: 1076: 1074: 1071: 1069: 1066: 1064: 1061: 1059: 1056: 1054: 1051: 1049: 1046: 1045: 1043: 1040: 1039: 1033: 1030: 1028: 1025: 1023: 1020: 1018: 1015: 1013: 1010: 1008: 1005: 1003: 1000: 998: 995: 993: 990: 988: 985: 983: 982:membrane raft 980: 978: 975: 973: 970: 968: 965: 963: 960: 958: 957:mitochondrion 955: 953: 950: 948: 945: 943: 940: 938: 935: 934: 932: 929: 928: 922: 919: 917: 914: 912: 909: 907: 904: 902: 899: 897: 894: 892: 889: 887: 884: 882: 879: 877: 874: 872: 869: 867: 864: 862: 859: 857: 854: 852: 849: 847: 844: 842: 839: 837: 834: 832: 829: 827: 824: 822: 819: 817: 814: 812: 809: 807: 804: 802: 799: 797: 794: 792: 789: 787: 784: 782: 779: 777: 774: 772: 769: 767: 764: 763: 761: 758: 757: 754: 753:Gene ontology 750: 746: 734: 729: 725: 720: 717: 715: 711: 703: 698: 687: 683: 679: 675: 671: 667: 663: 659: 655: 651: 650: 647: 643: 638: 635: 625: 621: 617: 613: 609: 605: 601: 597: 593: 589: 588: 585: 581: 576: 573: 572: 569: 567: 563: 561: 560: 556: 555: 552: 550: 546: 542: 538: 534: 526: 521: 517: 513: 508: 498: 494: 487: 480: 474: 467: 459: 455: 451: 446: 442: 437: 433: 425: 420: 416: 412: 407: 397: 393: 386: 379: 373: 366: 362: 356: 352: 348: 343: 339: 334: 330: 326: 322: 318: 314: 310: 306: 302: 298: 294: 290: 282: 277: 270: 265: 260: 249: 247: 243: 239: 235: 231: 227: 223: 219: 215: 211: 207: 203: 199: 195: 191: 187: 183: 179: 175: 171: 167: 163: 159: 155: 151: 147: 143: 139: 135: 131: 127: 123: 119: 115: 111: 107: 103: 99: 95: 91: 87: 81: 76: 73: 72: 68: 65: 58: 54: 49: 45: 41: 36: 31: 19: 3738: 3737: 3724: 3709: 3694: 3679: 3664: 3649: 3634: 3619: 3604: 3589: 3529: 3487: 3483: 3449:(7): 751–7. 3446: 3442: 3409: 3405: 3377: 3373: 3334: 3330: 3301: 3297: 3272: 3268: 3235: 3231: 3196: 3161: 3157: 3123:(1): 185–8. 3120: 3116: 3094:(1): 79–84. 3091: 3087: 3054: 3050: 3015: 3011: 2970: 2966: 2956: 2939: 2935: 2928: 2891: 2887: 2877: 2836: 2832: 2825: 2788: 2784: 2734: 2730: 2678: 2674: 2664: 2629: 2625: 2619: 2574: 2570: 2560: 2517: 2513: 2507: 2482: 2478: 2472: 2438:(11): e362. 2435: 2432:PLOS Biology 2431: 2421: 2394: 2390: 2380: 2353: 2349: 2339: 2312: 2308: 2298: 2284: 2254: 2245: 2236: 2227: 2125: 2124: 2121:Interactions 2112: 2083: 2069: 2058:nucleic acid 2035: 2033: 2022: 2012: 1993: 1974: 1972: 1949: 1935: 1927: 1923: 1921: 1896: 1888: 1884: 1883: 1806: 1784:NP_001116849 1781: 1755: 1733:NM_001123377 1730: 1706: 1687: 1661: 1642: 1616: 1597: 1577: 1572: 811:mRNA binding 564: 557: 523:150,998,894 510:150,981,590 284:External IDs 83: 3572:PDB gallery 3018:(1): 7–10. 2535:10045/94474 2050:nucleotides 1996:α-synuclein 1253:proteolysis 1032:nucleoplasm 886:RNA binding 680:Paneth cell 502:4|4 E2 262:Identifiers 2647:2115/53726 2520:: 134361. 2222:, May 2017 2201:, May 2017 2178:References 2086:DNA damage 2084:DJ-1 is a 2080:DNA repair 1498:DNA repair 1017:presynapse 568:(ortholog) 422:7,985,505 409:7,954,291 305:HomoloGene 2552:195813073 1980:chaperone 1968:peptidase 1960:α-helices 1958:and nine 1956:β-strands 1922:The gene 1906:Structure 1809:NP_065594 1788:NP_009193 1758:NM_020569 1737:NM_007262 1563:Orthologs 1363:autophagy 1007:cell body 987:chromatin 937:cytoplasm 313:GeneCards 3755:Category 3506:12851414 3471:44253517 3463:12815653 3434:13625056 3426:12548343 3396:11477070 3361:11462174 3318:11223268 3260:85481215 3252:17085780 3223:17017532 3188:15717024 3137:15503154 3108:15018843 3079:32685319 3071:14712351 3042:14513509 3034:12526767 2989:11477070 2948:12612053 2920:25071438 2869:27186691 2861:12446870 2817:37239999 2808:10218208 2761:28596309 2707:23792957 2656:18591768 2611:23844142 2571:PLOS ONE 2544:31276729 2499:16403519 2464:15502874 2413:12939276 2372:12761214 2331:12796482 2218:– 2197:– 2156:See also 2130:interact 2047:glycated 1990:Function 1857:Wikidata 1542:Sources: 1012:PML body 947:membrane 3536:PDBe-KB 3526:UniProt 3352:1235491 3289:9070310 3158:NeuroRx 3145:9453283 2911:4075472 2841:Bibcode 2833:Science 2739:Bibcode 2731:Science 2698:3829365 2602:3699467 2579:Bibcode 2220:Ensembl 2199:Ensembl 2054:Guanine 2044:glyoxal 2029:mercury 1984:Archaea 1946:Protein 1893:protein 1891:, is a 1675:UniProt 1630:Ensembl 1569:Species 1548:QuickGO 967:nucleus 942:cytosol 543:pattern 401:1p36.23 301:2135637 269:Aliases 3531:Q99497 3504:  3469:  3461:  3432:  3424:  3394:  3359:  3349:  3316:  3287:  3258:  3250:  3221:  3211:  3186:  3179:534935 3176:  3143:  3135:  3106:  3077:  3069:  3040:  3032:  3012:Neuron 2987:  2946:  2918:  2908:  2894:: 58. 2867:  2859:  2815:  2805:  2791:(10). 2759:  2705:  2695:  2654:  2609:  2599:  2550:  2542:  2497:  2462:  2455:521177 2452:  2411:  2370:  2329:  2143:EFCAB6 2132:with: 2025:copper 1938:has 8 1917:MEROPS 1843:search 1841:PubMed 1708:Q99LX0 1689:Q99497 1585:Entrez 714:BioGPS 293:602533 3467:S2CID 3430:S2CID 3256:S2CID 3141:S2CID 3075:S2CID 3038:S2CID 2865:S2CID 2548:S2CID 2149:PIAS2 2145:, and 2126:PARK7 2070:PARK7 2036:PARK7 2034:DJ-1/ 1964:dimer 1940:exons 1936:PARK7 1924:PARK7 1897:PARK7 1618:57320 1599:11315 1578:Mouse 1573:Human 1544:Amigo 590:tibia 566:Mouse 559:Human 506:Start 441:Mouse 405:Start 338:Human 317:PARK7 309:38295 276:PARK7 33:PARK7 18:PARK7 3725:2or3 3710:1ucf 3695:1soa 3680:1q2u 3665:1ps4 3650:1pe0 3635:1pdw 3620:1pdv 3605:1p5f 3590:1j42 3524:for 3502:PMID 3459:PMID 3422:PMID 3392:PMID 3357:PMID 3314:PMID 3298:Gene 3285:PMID 3248:PMID 3219:PMID 3209:ISBN 3184:PMID 3133:PMID 3104:PMID 3067:PMID 3030:PMID 2985:PMID 2944:PMID 2916:PMID 2857:PMID 2813:PMID 2757:PMID 2703:PMID 2652:PMID 2607:PMID 2540:PMID 2495:PMID 2460:PMID 2409:PMID 2368:PMID 2327:PMID 2137:CASK 2096:and 2042:and 2027:and 1928:DJ-1 1911:Gene 1900:gene 1027:axon 549:Bgee 497:Band 458:Chr. 396:Band 355:Chr. 289:OMIM 246:4S0Z 242:4RKY 238:4RKW 234:4ZGG 230:4P36 226:4P35 222:4P34 218:4P2G 214:4OQ4 210:4OGF 206:4N12 202:4N0M 198:4MTC 194:4MNT 190:4BTE 186:3SF8 182:3F71 178:3EZG 174:3CZA 170:3CZ9 166:3CYF 162:3CY6 158:3BWE 154:3B3A 150:3B38 146:3B36 142:2RK6 138:2RK4 134:2RK3 130:2R1V 126:2R1U 122:2R1T 118:2OR3 114:1UCF 110:1SOA 106:1Q2U 102:1PE0 98:1PDW 94:1PDV 90:1P5F 86:1J42 67:RCSB 64:PDBe 3522:PDB 3492:doi 3488:278 3451:doi 3414:doi 3382:doi 3378:276 3347:PMC 3339:doi 3306:doi 3302:263 3277:doi 3273:231 3240:doi 3201:doi 3174:PMC 3166:doi 3125:doi 3121:318 3096:doi 3059:doi 3020:doi 2975:doi 2971:276 2906:PMC 2896:doi 2849:doi 2837:299 2803:PMC 2793:doi 2747:doi 2735:357 2693:PMC 2683:doi 2679:288 2642:hdl 2634:doi 2597:PMC 2587:doi 2530:hdl 2522:doi 2518:708 2487:doi 2483:356 2450:PMC 2440:doi 2399:doi 2395:278 2358:doi 2354:278 2317:doi 2313:278 2117:7. 2066:RNA 2064:or 2062:DNA 2052:. 1952:kDa 519:End 418:End 321:OMA 297:MGI 57:PDB 3757:: 3528:: 3500:. 3486:. 3482:. 3465:. 3457:. 3447:18 3445:. 3428:. 3420:. 3410:23 3408:. 3390:. 3376:. 3372:. 3355:. 3345:. 3335:69 3333:. 3329:. 3312:. 3300:. 3283:. 3271:. 3254:. 3246:. 3236:29 3234:. 3217:. 3207:. 3182:. 3172:. 3160:. 3156:. 3139:. 3131:. 3119:. 3102:. 3090:. 3073:. 3065:. 3055:82 3053:. 3036:. 3028:. 3016:37 3014:. 3010:. 2983:. 2969:. 2965:. 2938:. 2914:. 2904:. 2890:. 2886:. 2863:. 2855:. 2847:. 2835:. 2811:. 2801:. 2789:24 2787:. 2783:. 2769:^ 2755:. 2745:. 2733:. 2729:. 2715:^ 2701:. 2691:. 2677:. 2673:. 2650:. 2640:. 2630:31 2628:. 2605:. 2595:. 2585:. 2573:. 2569:. 2546:. 2538:. 2528:. 2516:. 2493:. 2481:. 2458:. 2448:. 2434:. 2430:. 2407:. 2393:. 2389:. 2366:. 2352:. 2348:. 2325:. 2311:. 2307:. 2263:^ 2253:. 2235:. 2206:^ 2185:^ 2076:. 2031:. 2020:. 1902:. 1546:/ 525:bp 512:bp 424:bp 411:bp 319:; 315:: 311:; 307:: 303:; 299:: 295:; 291:: 244:, 240:, 236:, 232:, 228:, 224:, 220:, 216:, 212:, 208:, 204:, 200:, 196:, 192:, 188:, 184:, 180:, 176:, 172:, 168:, 164:, 160:, 156:, 152:, 148:, 144:, 140:, 136:, 132:, 128:, 124:, 120:, 116:, 112:, 108:, 104:, 100:, 96:, 92:, 88:, 3747:. 3565:e 3558:t 3551:v 3538:. 3508:. 3494:: 3473:. 3453:: 3436:. 3416:: 3398:. 3384:: 3363:. 3341:: 3320:. 3308:: 3291:. 3279:: 3262:. 3242:: 3225:. 3203:: 3190:. 3168:: 3162:1 3147:. 3127:: 3110:. 3098:: 3092:4 3081:. 3061:: 3044:. 3022:: 2991:. 2977:: 2950:. 2940:1 2922:. 2898:: 2892:7 2871:. 2851:: 2843:: 2819:. 2795:: 2763:. 2749:: 2741:: 2709:. 2685:: 2658:. 2644:: 2636:: 2613:. 2589:: 2581:: 2575:8 2554:. 2532:: 2524:: 2501:. 2489:: 2466:. 2442:: 2436:2 2415:. 2401:: 2374:. 2360:: 2333:. 2319:: 2292:. 2278:. 2257:. 2239:. 2151:. 2139:, 2060:( 1919:. 443:) 340:) 323:: 20:)

Index

PARK7

PDB
PDBe
RCSB
1J42
1P5F
1PDV
1PDW
1PE0
1Q2U
1SOA
1UCF
2OR3
2R1T
2R1U
2R1V
2RK3
2RK4
2RK6
3B36
3B38
3B3A
3BWE
3CY6
3CYF
3CZ9
3CZA
3EZG
3F71

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