Knowledge (XXG)

PCM1

Source πŸ“

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studies performed found that PCM1 was present in centriolar satellites and in electron dense granules between 70 and 100 nm in diameter. These were originally thought to be scattered only around the centrosomes, but further studies proved that PCM1 was also found throughout the cytoplasm.
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was also dramatically reduced after PCM1 depletion using siRNA, overexpression of PCM1 deletion mutants and PCM1 antibody microinjection. As a result of this depletion, the radial organization of the microtubules was found to be disrupted, but did not appear to affect microtubule nucleation.
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Gurling HM, Critchley H, Datta SR, McQuillin A, Blaveri E, Thirumalai S, Pimm J, Krasucki R, Kalsi G, Quested D, Lawrence J, Bass N, Choudhury K, Puri V, O'Daly O, Curtis D, Blackwood D, Muir W, Malhotra AK, Buchanan RW, Good CD, Frackowiak RS, Dolan RJ (August 2006).
1244:. If an isoleucine amino acid change in PCM1 is inherited the risk of developing schizophrenia was found to be 68% in two independent samples from south England and Scotland. This means that it may now be possible to offer very limited 1556:
Datta SR, McQuillin A, Rizig M, Blaveri E, Thirumalai S, Kalsi G, Lawrence J, Bass NJ, Puri V, Choudhury K, Pimm J, Crombie C, Fraser G, Walker N, Curtis D, Zvelebil M, Pereira A, Kandaswamy R, St Clair D, Gurling HM (December 2008).
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Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry".
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Li, Q; Hansen D; Killilea A; Joshi H C; Palazzo R E; Balczon R (February 2001). "Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1".
152: 1139:. The protein appears to associate with the centrosome complex during the cell cycle. Dissociation occurs during mitosis when PCM1 is dispersed throughout the cell. 2022:"Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries" 1147:
PCM1 was shown to be essential for cell division because PCM1 antibodies cause cell-cycle arrest when microinjected into fertilized murine eggs. Targeting of
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Li Q, Hansen D, Killilea A, et al. (2001). "Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1".
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Ohata H, Fujiwara Y, Koyama K, Nakamura Y (1995). "Mapping of the human autoantigen pericentriolar material 1 (PCM1) gene to chromosome 8p21.3-p22".
1601:"Genetic Association and Brain Morphology Studies and the Chromosome 8p22 Pericentriolar Material 1 (PCM1) Gene in Susceptibility to Schizophrenia" 2233:"The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression" 1648:
Kamiya A, Tan PL, Kubo K, Engelhard C, Ishizuka K, Kubo A, Tsukita S, Pulver AE, Nakajima K, Cascella NG, Katsanis N, Sawa A (September 2008).
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domain and a eukaryotic molybdopterin domain. The eukaryotic molybdopterin binding domain is currently found in only five other human genes,
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Ansley SJ, Badano JL, Blacque OE, et al. (2003). "Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome".
138: 1263:), which provides a link between aberrant PCM1 and the abnormal cortical development associated with the pathology of schizophrenia. 1049: 115: 1353: 1304: 1559:"A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia" 1650:"PCM1 is recruited to the centrosome by the cooperative action of DISC1 and BBS4 and is a candidate for psychiatric illness" 1300: 2464:"Dynamic Recruitment of Nek2 Kinase to the Centrosome Involves Microtubules, PCM-1, and Localized Proteasomal Degradation" 1418:"Dynamic Recruitment of Nek2 Kinase to the Centrosome Involves Microtubules, PCM-1, and Localized Proteasomal Degradation" 1228:. In humans it is expressed above the median level of central nervous system (CNS) expression in most parts of the brain. 57: 1272: 1189: 151: 144: 2590: 729: 65: 2421:"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" 2672: 1205: 710: 1193: 1177: 2542:"PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation" 2507:"The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2" 1535: 2863: 2344: 2160: 2111: 1916: 982: 2298:"Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers" 44: 2583: 1245: 1027: 1023: 1013: 1009: 1005: 1001: 978: 974: 970: 966: 962: 958: 954: 950: 946: 942: 938: 934: 930: 926: 922: 918: 914: 910: 906: 902: 898: 894: 890: 886: 882: 878: 874: 864: 860: 852: 848: 807: 803: 2184: 1784: 1169: 89: 2100:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" 997: 856: 828: 799: 2563: 2528: 2493: 2450: 2407: 2372: 2319: 2284: 2254: 2219: 2176: 2139: 2086: 2043: 2008: 1979: 1944: 1891: 1856: 1813: 1776: 1722: 1714: 1679: 1630: 1580: 1496: 1447: 1398: 37: 2553: 2518: 2483: 2475: 2440: 2432: 2397: 2362: 2352: 2309: 2276: 2244: 2209: 2168: 2129: 2119: 2076: 2068: 2033: 2000: 1969: 1934: 1924: 1881: 1846: 1838: 1805: 1766: 1758: 1706: 1669: 1661: 1620: 1612: 1570: 1486: 1478: 1437: 1429: 1388: 1380: 1201: 355: 348: 341: 231: 162: 106: 1248:
to a small proportion of people with schizophrenia who are also carriers of this mutation.
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Hames RS, Crookes RE, Straatman KR, Merdes A, Hayes MJ, Faragher AJ, Fry AM (April 2005).
1197: 206: 85: 1870:"Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin" 2348: 2164: 2115: 1920: 1771: 1746: 2488: 2463: 2081: 2056: 1851: 1826: 1674: 1649: 1625: 1600: 1514: 1491: 1466: 1442: 1417: 1393: 1368: 1140: 2445: 2420: 2367: 2332: 2134: 2099: 599: 594: 589: 584: 579: 574: 569: 564: 559: 554: 549: 544: 539: 534: 529: 524: 519: 514: 509: 493: 488: 483: 478: 473: 468: 463: 458: 453: 448: 443: 438: 433: 428: 423: 418: 402: 397: 2857: 1939: 1904: 1241: 384: 2575: 69: 2188: 1788: 224: 2523: 2506: 93: 2057:"Assembly of centrosomal proteins and microtubule organization depends on PCM-1" 1905:"Shotgun sequencing of the human transcriptome with ORF expressed sequence tags" 1827:"PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution" 1467:"Assembly of centrosomal proteins and microtubule organization depends on PCM-1" 1369:"PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution" 1340:
National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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PCM1 has four known transcripts, the longest of which has 39 exons. The
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The PCM1 protein was originally identified by virtue of its distinct
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of PCM1 encodes a protein of 2024 amino acids. The protein contains
2333:"Large-scale characterization of HeLa cell nuclear phosphoproteins" 2249: 2232: 2214: 2197: 2829: 2779: 2769: 2764: 2759: 2754: 2749: 2744: 2739: 2734: 2710: 2705: 2656: 2652: 2648: 2629: 2624: 1256: 1209: 1903:
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000).
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Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004).
1958:"RET/PCM-1: a novel fusion gene in papillary thyroid carcinoma" 1208:
precursor and the ATPbinding cassette, sub-family A, member 2 (
364: 2685: 1747:"Centriolar satellites: key mediators of centrosome functions" 1515:"Gene Expression Summary for Pcm1; pericentriolar material 1" 2098:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
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Murati A, Gelsi-Boyer V, AdΓ©laΓ―de J, et al. (2005).
2386:"Phosphoproteomic analysis of the developing mouse brain" 2462:
Hames RS, Crookes RE, Straatman KR, et al. (2005).
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Ballif BA, VillΓ©n J, Beausoleil SA, et al. (2005).
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gene have been shown to cause genetic susceptibility to
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Gerhard DS, Wagner L, Feingold EA, et al. (2004).
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Engelender S, Sharp AH, Colomer V, et al. (1998).
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Tollenaere M.A.X.; Mailand N; Bekker-Jensen S (2014).
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regions between areas of low complexity as well as an
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positive regulation of intracellular protein transport
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Armes JE, Hammet F, de Silva M, et al. (2004).
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regulation of G2/M transition of mitotic cell cycle
2196:Ota T, Suzuki Y, Nishikawa T, et al. (2004). 2020:Kumar S, Connor JR, Dodds RA, et al. (2001). 1296: 1294: 1292: 525:intraciliary transport involved in cilium assembly 2505:Reiter A, Walz C, Watmore A, et al. (2005). 2231:Kim JC, Badano JL, Sibold S, et al. (2004). 161: 16:Protein-coding gene in the species Homo sapiens 1956:Corvi R, Berger N, Balczon R, Romeo G (2000). 1301:GRCm38: Ensembl release 89: ENSMUSG00000031592 2591: 1354:"Entrez Gene: PCM1 pericentriolar material 1" 8: 48:, PTC4, RET/PCM-1, pericentriolar material 1 2598: 2584: 2576: 1367:Balczon R, Bao L, Zimmer WE (March 1994). 993: 844: 625: 580:ciliary basal body-plasma membrane docking 380: 202: 101: 2557: 2522: 2487: 2444: 2401: 2366: 2356: 2313: 2248: 2213: 2133: 2123: 2080: 2037: 1973: 1938: 1928: 1885: 1850: 1770: 1673: 1624: 1574: 1490: 1441: 1392: 520:neuronal stem cell population maintenance 1288: 1259:) and Bardet-Biedl syndrome 4 protein ( 18: 535:G2/M transition of mitotic cell cycle 166: 127: 122: 7: 1825:Balczon R, Bao L, Zimmer WE (1994). 1224:has been found to be highest in the 540:cytoplasmic microtubule organization 1517:. Allen Institute for Brain Science 1465:Dammermann, A.; Merdes, A. (2002). 1255:with disrupted-in-schizophrenia 1 ( 555:microtubule anchoring at centrosome 545:negative regulation of neurogenesis 1538:. BioGPS - your Gene Portal System 1112:which in humans is encoded by the 818: 789: 765: 746: 720: 701: 675: 656: 560:protein localization to centrosome 336: 259: 240: 219: 14: 600:protein localization to organelle 1131:-dependent association with the 354: 347: 340: 150: 143: 137: 114: 2055:Dammermann A, Merdes A (2002). 550:interkinetic nuclear migration 365:More reference expression data 1: 2524:10.1158/0008-5472.CAN-04-4263 1536:"PCM1, Probe set 202174_s_at" 439:microtubule organizing center 135: 2337:Proc. Natl. Acad. Sci. U.S.A 2104:Proc. Natl. Acad. Sci. U.S.A 1909:Proc. Natl. Acad. Sci. U.S.A 1251:PCM1 forms a complex at the 1220:PCM1 mRNA expression in the 530:cell projection organization 1471:The Journal of Cell Biology 1200:(mitochondrial precursor), 2880: 2403:10.1074/mcp.M400085-MCP200 585:non-motile cilium assembly 494:protein-containing complex 1763:10.1007/s00018-014-1711-3 1666:10.1001/archpsyc.65.9.996 1617:10.1001/archpsyc.63.8.844 1336:"Mouse PubMed Reference:" 1318:"Human PubMed Reference:" 1102:Pericentriolar material 1 1088: 1083: 1079: 1072: 1056: 1039: 1020: 871: 840: 825: 796: 785: 772: 768: 753: 749: 740: 727: 723: 708: 704: 695: 682: 678: 663: 659: 650: 635: 628: 624: 608: 403:identical protein binding 383: 379: 362: 339: 330: 322: 271: 262: 247: 243: 213: 205: 201: 184: 171: 134: 113: 104: 100: 55: 52: 42: 35: 30: 26: 21: 2673:Pericentriolar material 2480:10.1091/mbc.E04-08-0688 2358:10.1073/pnas.0404720101 1434:10.1091/mbc.E04-08-0688 1271:PCM1 has been shown to 1206:erythropoietin receptor 1050:Chr 8: 41.24 – 41.33 Mb 469:pericentriolar material 454:ciliary transition zone 2559:10.1038/sj.leu.2403879 2315:10.1038/sj.onc.1207740 2125:10.1073/pnas.242603899 2039:10.1053/joca.2001.0421 1975:10.1038/sj.onc.1203772 1930:10.1073/pnas.97.7.3491 1810:10.1006/geno.1994.1640 1194:xanthine dehydrogenase 1178:adenosine triphosphate 2390:Mol. Cell. Proteomics 2073:10.1083/jcb.200204023 2005:10.1242/jcs.114.4.797 1887:10.1093/hmg/6.13.2205 1843:10.1083/jcb.124.5.783 1711:10.1242/jcs.114.4.797 1654:Arch. Gen. Psychiatry 1605:Arch. Gen. Psychiatry 1483:10.1083/jcb.200204023 1385:10.1083/jcb.124.5.783 1232:Clinical significance 565:microtubule anchoring 1190:nuclear localization 464:centriolar satellite 168:8 A4|8 23.89 cM 129:Chromosome 8 (mouse) 2349:2004PNAS..10112130B 2173:10.1038/nature02030 2165:2003Natur.425..628A 2116:2002PNAS...9916899M 1921:2000PNAS...97.3491D 1751:Cell. Mol. Life Sci 1576:10.1038/mp.2008.128 1246:genetic counselling 1216:Tissue distribution 484:apical part of cell 2610:and its components 2437:10.1101/gr.2596504 2026:Osteoarthr. Cartil 1170:open reading frame 730:ENSMUSG00000031592 503:Biological process 419:ciliary basal body 412:Cellular component 391:Molecular function 2848: 2847: 2281:10.1021/ac035352d 2110:(26): 16899–903. 1999:(Pt 4): 797–809. 1705:(Pt 4): 797–809. 1236:Mutations in the 1099: 1098: 1095: 1094: 1068: 1067: 1035: 1034: 990: 989: 836: 835: 815: 814: 781: 780: 762: 761: 736: 735: 717: 716: 691: 690: 672: 671: 620: 619: 489:non-motile cilium 375: 374: 371: 370: 326: 325: 318: 317: 256: 255: 197: 196: 2871: 2600: 2593: 2586: 2577: 2571: 2561: 2536: 2526: 2501: 2491: 2458: 2448: 2415: 2405: 2396:(11): 1093–101. 2380: 2370: 2360: 2327: 2317: 2308:(33): 5697–702. 2292: 2262: 2252: 2227: 2217: 2192: 2159:(6958): 628–33. 2147: 2137: 2127: 2094: 2084: 2051: 2041: 2016: 1987: 1977: 1952: 1942: 1932: 1899: 1889: 1864: 1854: 1821: 1792: 1774: 1731: 1730: 1694: 1688: 1687: 1677: 1645: 1639: 1638: 1628: 1595: 1589: 1588: 1578: 1553: 1547: 1546: 1544: 1543: 1532: 1526: 1525: 1523: 1522: 1511: 1505: 1504: 1494: 1462: 1456: 1455: 1445: 1413: 1407: 1406: 1396: 1364: 1358: 1357: 1350: 1344: 1343: 1332: 1326: 1325: 1314: 1308: 1298: 1202:aldehyde oxidase 1104:, also known as 1081: 1080: 1052: 1045: 1030: 994: 985: 845: 841:RefSeq (protein) 831: 819: 810: 790: 766: 747: 721: 702: 676: 657: 626: 590:centrosome cycle 515:neuron migration 429:nuclear membrane 381: 367: 358: 351: 344: 337: 291:ventricular zone 279:genital tubercle 267: 265:Top expressed in 260: 241: 220: 203: 193: 180: 169: 154: 147: 141: 130: 118: 102: 96: 94:PCM1 - orthologs 47: 40: 19: 2879: 2878: 2874: 2873: 2872: 2870: 2869: 2868: 2854: 2853: 2851: 2849: 2844: 2715: 2667: 2611: 2604: 2574: 2539: 2504: 2468:Mol. Biol. Cell 2461: 2431:(10B): 2121–7. 2418: 2383: 2343:(33): 12130–5. 2330: 2295: 2275:(10): 2763–72. 2265: 2230: 2195: 2150: 2097: 2054: 2019: 1990: 1968:(37): 4236–42. 1955: 1902: 1880:(13): 2205–12. 1874:Hum. Mol. Genet 1867: 1824: 1795: 1744: 1740: 1738:Further reading 1735: 1734: 1696: 1695: 1691: 1660:(9): 996–1006. 1647: 1646: 1642: 1597: 1596: 1592: 1563:Mol. Psychiatry 1555: 1554: 1550: 1541: 1539: 1534: 1533: 1529: 1520: 1518: 1513: 1512: 1508: 1464: 1463: 1459: 1422:Mol. Biol. Cell 1415: 1414: 1410: 1366: 1365: 1361: 1352: 1351: 1347: 1334: 1333: 1329: 1316: 1315: 1311: 1299: 1290: 1285: 1269: 1234: 1218: 1198:sulfite oxidase 1166: 1125: 1090:View/Edit Mouse 1085:View/Edit Human 1048: 1043: 1040:Location (UCSC) 1026: 1022: 1016: 1012: 1008: 1004: 1000: 981: 977: 973: 969: 965: 961: 957: 953: 949: 945: 941: 937: 933: 929: 925: 921: 917: 913: 909: 905: 901: 897: 893: 889: 885: 881: 877: 873: 867: 863: 859: 855: 851: 827: 806: 802: 798: 711:ENSG00000078674 604: 575:cilium assembly 570:social behavior 498: 424:cell projection 407: 398:protein binding 363: 353: 352: 346: 345: 314: 309: 305: 303:ascending aorta 301: 297: 293: 289: 285: 281: 277: 263: 252: 188: 175: 167: 157: 156: 155: 148: 128: 105:Gene location ( 56: 43: 36: 17: 12: 11: 5: 2877: 2875: 2867: 2866: 2856: 2855: 2846: 2845: 2843: 2842: 2837: 2832: 2827: 2822: 2817: 2812: 2807: 2802: 2797: 2792: 2787: 2782: 2777: 2772: 2767: 2762: 2757: 2752: 2747: 2742: 2737: 2732: 2726: 2724: 2717: 2716: 2714: 2713: 2708: 2703: 2698: 2693: 2688: 2683: 2677: 2675: 2669: 2668: 2666: 2665: 2660: 2642: 2637: 2632: 2627: 2621: 2619: 2613: 2612: 2605: 2603: 2602: 2595: 2588: 2580: 2573: 2572: 2537: 2502: 2474:(4): 1711–24. 2459: 2416: 2381: 2328: 2293: 2263: 2250:10.1038/ng1352 2228: 2215:10.1038/ng1285 2193: 2148: 2095: 2052: 2017: 1988: 1953: 1900: 1865: 1822: 1793: 1741: 1739: 1736: 1733: 1732: 1689: 1640: 1590: 1548: 1527: 1506: 1477:(2): 255–266. 1457: 1428:(4): 1711–24. 1408: 1359: 1345: 1327: 1309: 1287: 1286: 1284: 1281: 1268: 1265: 1233: 1230: 1217: 1214: 1165: 1164:Gene structure 1162: 1141:Immunolabeling 1124: 1121: 1097: 1096: 1093: 1092: 1087: 1077: 1076: 1070: 1069: 1066: 1065: 1063: 1061: 1054: 1053: 1046: 1041: 1037: 1036: 1033: 1032: 1018: 1017: 991: 988: 987: 983:NP_001302436.1 869: 868: 842: 838: 837: 834: 833: 823: 822: 816: 813: 812: 794: 793: 787: 783: 782: 779: 778: 770: 769: 763: 760: 759: 751: 750: 744: 738: 737: 734: 733: 725: 724: 718: 715: 714: 706: 705: 699: 693: 692: 689: 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1537: 1531: 1528: 1516: 1510: 1507: 1502: 1498: 1493: 1488: 1484: 1480: 1476: 1472: 1468: 1461: 1458: 1453: 1449: 1444: 1439: 1435: 1431: 1427: 1423: 1419: 1412: 1409: 1404: 1400: 1395: 1390: 1386: 1382: 1379:(5): 783–93. 1378: 1374: 1370: 1363: 1360: 1355: 1349: 1346: 1341: 1337: 1331: 1328: 1323: 1319: 1313: 1310: 1306: 1302: 1297: 1295: 1293: 1289: 1282: 1280: 1278: 1274: 1266: 1264: 1262: 1258: 1254: 1249: 1247: 1243: 1242:schizophrenia 1239: 1231: 1229: 1227: 1223: 1215: 1213: 1211: 1207: 1203: 1199: 1195: 1191: 1187: 1183: 1179: 1175: 1171: 1163: 1161: 1158: 1154: 1150: 1145: 1142: 1138: 1134: 1130: 1122: 1120: 1118: 1115: 1111: 1107: 1103: 1091: 1086: 1082: 1078: 1075: 1071: 1064: 1062: 1059: 1055: 1051: 1047: 1042: 1038: 1031: 1029: 1025: 1019: 1015: 1011: 1007: 1003: 999: 995: 992: 986: 984: 980: 976: 972: 968: 964: 960: 956: 952: 948: 944: 940: 936: 932: 928: 924: 920: 916: 912: 908: 904: 900: 896: 892: 888: 884: 880: 876: 870: 866: 862: 858: 854: 850: 846: 843: 839: 832: 830: 824: 820: 817: 811: 809: 805: 801: 795: 791: 788: 786:RefSeq (mRNA) 784: 777: 776: 771: 767: 764: 758: 757: 752: 748: 745: 743: 739: 732: 731: 726: 722: 719: 713: 712: 707: 703: 700: 698: 694: 687: 686: 681: 677: 674: 668: 667: 662: 658: 655: 653: 649: 646: 643: 641: 638: 634: 631: 627: 623: 616: 612: 607: 601: 598: 596: 593: 591: 588: 586: 583: 581: 578: 576: 573: 571: 568: 566: 563: 561: 558: 556: 553: 551: 548: 546: 543: 541: 538: 536: 533: 531: 528: 526: 523: 521: 518: 516: 513: 511: 508: 507: 505: 502: 501: 495: 492: 490: 487: 485: 482: 480: 477: 475: 472: 470: 467: 465: 462: 460: 457: 455: 452: 450: 447: 445: 442: 440: 437: 435: 432: 430: 427: 425: 422: 420: 417: 416: 414: 411: 410: 404: 401: 399: 396: 395: 393: 390: 389: 386: 385:Gene ontology 382: 378: 366: 361: 357: 350: 343: 338: 335: 333: 329: 321: 310: 306: 302: 298: 294: 290: 286: 282: 278: 274: 273: 270: 266: 261: 258: 249: 246: 242: 239: 238: 235: 233: 229: 227: 226: 222: 221: 218: 216: 212: 208: 204: 200: 192: 187: 183: 179: 174: 164: 160: 153: 146: 140: 133: 125: 121: 117: 112: 108: 103: 99: 95: 91: 87: 83: 79: 75: 71: 67: 63: 59: 51: 46: 39: 34: 29: 25: 20: 2850: 2690: 2549: 2545: 2514: 2510: 2471: 2467: 2428: 2424: 2393: 2389: 2340: 2336: 2305: 2301: 2272: 2268: 2240: 2236: 2205: 2201: 2156: 2152: 2107: 2103: 2064: 2061:J. Cell Biol 2060: 2029: 2025: 1996: 1992: 1965: 1961: 1912: 1908: 1877: 1873: 1834: 1831:J. Cell Biol 1830: 1804:(2): 404–6. 1801: 1797: 1757:(1): 11–23. 1754: 1750: 1702: 1698: 1692: 1657: 1653: 1643: 1608: 1604: 1593: 1566: 1562: 1551: 1540:. Retrieved 1530: 1519:. Retrieved 1509: 1474: 1470: 1460: 1425: 1421: 1411: 1376: 1373:J. Cell Biol 1372: 1362: 1348: 1339: 1330: 1321: 1312: 1270: 1267:Interactions 1250: 1237: 1235: 1219: 1167: 1146: 1137:microtubules 1135:complex and 1126: 1113: 1105: 1101: 1100: 1028:NP_001390754 1024:NP_001390753 1021: 1014:NP_001390752 1010:NP_001390749 1006:NP_001390748 1002:NP_001390746 979:NP_001339589 975:NP_001339588 971:NP_001339587 967:NP_001339586 963:NP_001339585 959:NP_001339584 955:NP_001339583 951:NP_001339582 947:NP_001339581 943:NP_001339580 939:NP_001339579 935:NP_001339578 931:NP_001339577 927:NP_001339576 923:NP_001339575 919:NP_001339574 915:NP_001339573 911:NP_001339572 907:NP_001339571 903:NP_001339570 899:NP_001339569 895:NP_001339568 891:NP_001339567 887:NP_001339566 883:NP_001339565 879:NP_001339564 875:NP_001339563 872: 865:NP_001339562 861:NP_001339561 853:NP_001302437 849:NP_001302436 826: 808:NM_001315508 804:NM_001315507 797: 773: 754: 728: 709: 683: 664: 644: 639: 449:cytoskeleton 311:otic vesicle 299:otic placode 275:spermatocyte 230: 223: 53:External IDs 2864:Human genes 2208:(1): 40–5. 1993:J. Cell Sci 1699:J. Cell Sci 1226:hippocampus 1222:mouse brain 1174:coiled coil 1153:pericentrin 189:41,332,344 176:41,239,752 31:Identifiers 2617:Centrioles 2608:centrosome 2511:Cancer Res 2425:Genome Res 2269:Anal. Chem 2237:Nat. Genet 2202:Nat. Genet 1542:2009-04-30 1521:2009-04-30 1307:, May 2017 1283:References 1253:centrosome 1188:domain, a 1133:centrosome 1129:cell cycle 459:centrosome 234:(ortholog) 74:HomoloGene 1719:0021-9533 998:NP_076151 857:NP_006188 829:NM_023662 800:NM_006197 630:Orthologs 474:cytoplasm 444:centriole 295:spermatid 82:GeneCards 2858:Category 2722:proteins 2645:Centrins 2568:16034466 2546:Leukemia 2533:15805263 2498:15659651 2455:15489334 2412:15345747 2377:15302935 2324:15184884 2302:Oncogene 2289:15144186 2259:15107855 2224:14702039 2181:14520415 2144:12477932 2091:12403812 2048:11597177 2013:11171385 1984:10980597 1962:Oncogene 1949:10737800 1798:Genomics 1781:25173771 1772:11114028 1727:11171385 1684:18762586 1635:16894060 1585:19048012 1501:12403812 1452:15659651 1303:– 1273:interact 1123:Function 1074:Wikidata 609:Sources: 434:membrane 2489:1073654 2345:Bibcode 2189:4310157 2161:Bibcode 2112:Bibcode 2082:2173044 1917:Bibcode 1896:9361024 1861:8120099 1852:2119948 1818:7698772 1789:2243856 1675:2727928 1626:2634866 1492:2173044 1443:1073654 1403:8120099 1394:2119948 1305:Ensembl 1149:centrin 1110:protein 1108:, is a 742:UniProt 697:Ensembl 636:Species 615:QuickGO 479:cytosol 287:saccule 209:pattern 70:1277958 38:Aliases 2825:CEP350 2820:CEP250 2815:CEP215 2810:CEP192 2805:CEP170 2800:CEP164 2795:CEP152 2790:CEP135 2785:CEP120 2730:CCP110 2720:other 2640:CEP104 2635:CNTROB 2566:  2531:  2496:  2486:  2453:  2446:528928 2443:  2410:  2375:  2368:514446 2365:  2322:  2287:  2257:  2222:  2187:  2179:  2153:Nature 2142:  2135:139241 2132:  2089:  2079:  2046:  2011:  1982:  1947:  1937:  1894:  1859:  1849:  1816:  1787:  1779:  1769:  1725:  1717:  1682:  1672:  1633:  1623:  1583:  1499:  1489:  1450:  1440:  1401:  1391:  1186:GTPase 1157:ninein 1060:search 1058:PubMed 775:Q9R0L6 756:Q15154 652:Entrez 332:BioGPS 307:zygote 62:600299 2830:CNTRL 2780:CEP97 2775:CEP90 2770:CEP78 2765:CEP76 2760:CEP72 2755:CEP70 2750:CEP68 2745:CEP63 2740:CEP57 2735:CEP55 2711:TUBE1 2706:TNKS2 2657:CETN3 2653:CETN2 2649:CETN1 2630:CENPJ 2625:SASS6 2185:S2CID 1940:16267 1785:S2CID 1275:with 1257:DISC1 1210:ABCA2 685:18536 645:Mouse 640:Human 611:Amigo 232:Mouse 225:Human 172:Start 107:Mouse 2840:NINL 2701:TNKS 2696:PCNT 2691:PCM1 2681:BBS4 2663:SFI1 2655:and 2606:The 2564:PMID 2529:PMID 2494:PMID 2451:PMID 2408:PMID 2373:PMID 2320:PMID 2285:PMID 2255:PMID 2220:PMID 2177:PMID 2140:PMID 2087:PMID 2044:PMID 2009:PMID 1980:PMID 1945:PMID 1892:PMID 1857:PMID 1814:PMID 1777:PMID 1723:PMID 1715:ISSN 1680:PMID 1631:PMID 1581:PMID 1497:PMID 1448:PMID 1399:PMID 1277:PCNT 1261:BBS4 1238:PCM1 1184:) / 1155:and 1117:gene 1114:PCM1 1106:PCM1 666:5108 215:Bgee 163:Band 124:Chr. 86:PCM1 78:4518 58:OMIM 45:PCM1 22:PCM1 2835:NIN 2686:Lck 2554:doi 2519:doi 2484:PMC 2476:doi 2441:PMC 2433:doi 2398:doi 2363:PMC 2353:doi 2341:101 2310:doi 2277:doi 2245:doi 2210:doi 2169:doi 2157:425 2130:PMC 2120:doi 2077:PMC 2069:doi 2065:159 2034:doi 2001:doi 1997:114 1970:doi 1935:PMC 1925:doi 1882:doi 1847:PMC 1839:doi 1835:124 1806:doi 1767:PMC 1759:doi 1707:doi 1703:114 1670:PMC 1662:doi 1621:PMC 1613:doi 1571:doi 1487:PMC 1479:doi 1475:159 1438:PMC 1430:doi 1389:PMC 1381:doi 1377:124 1212:). 1182:ATP 1044:n/a 250:n/a 185:End 90:OMA 66:MGI 2860:: 2651:, 2562:. 2550:19 2548:. 2544:. 2527:. 2515:65 2513:. 2509:. 2492:. 2482:. 2472:16 2470:. 2466:. 2449:. 2439:. 2429:14 2427:. 2423:. 2406:. 2392:. 2388:. 2371:. 2361:. 2351:. 2339:. 2335:. 2318:. 2306:23 2304:. 2300:. 2283:. 2273:76 2271:. 2253:. 2241:36 2239:. 2235:. 2218:. 2206:36 2204:. 2200:. 2183:. 2175:. 2167:. 2155:. 2138:. 2128:. 2118:. 2108:99 2106:. 2102:. 2085:. 2075:. 2063:. 2059:. 2042:. 2028:. 2024:. 2007:. 1995:. 1978:. 1966:19 1964:. 1960:. 1943:. 1933:. 1923:. 1913:97 1911:. 1907:. 1890:. 1876:. 1872:. 1855:. 1845:. 1833:. 1829:. 1812:. 1802:24 1800:. 1783:. 1775:. 1765:. 1755:72 1753:. 1749:. 1721:. 1713:. 1701:. 1678:. 1668:. 1658:65 1656:. 1652:. 1629:. 1619:. 1609:63 1607:. 1603:. 1579:. 1567:15 1565:. 1561:. 1495:. 1485:. 1473:. 1469:. 1446:. 1436:. 1426:16 1424:. 1420:. 1397:. 1387:. 1375:. 1371:. 1338:. 1320:. 1291:^ 1279:. 1204:, 1196:, 1151:, 1119:. 613:/ 191:bp 178:bp 88:; 84:: 80:; 76:: 72:; 68:: 64:; 60:: 2659:) 2647:( 2599:e 2592:t 2585:v 2570:. 2556:: 2535:. 2521:: 2500:. 2478:: 2457:. 2435:: 2414:. 2400:: 2394:3 2379:. 2355:: 2347:: 2326:. 2312:: 2291:. 2279:: 2261:. 2247:: 2226:. 2212:: 2191:. 2171:: 2163:: 2146:. 2122:: 2114:: 2093:. 2071:: 2050:. 2036:: 2030:9 2015:. 2003:: 1986:. 1972:: 1951:. 1927:: 1919:: 1898:. 1884:: 1878:6 1863:. 1841:: 1820:. 1808:: 1791:. 1761:: 1729:. 1709:: 1686:. 1664:: 1637:. 1615:: 1587:. 1573:: 1545:. 1524:. 1503:. 1481:: 1454:. 1432:: 1405:. 1383:: 1356:. 1342:. 1324:. 1180:( 109:) 92::

Index

Aliases
PCM1
OMIM
600299
MGI
1277958
HomoloGene
4518
GeneCards
PCM1
OMA
PCM1 - orthologs
Mouse
Chromosome 8 (mouse)
Chr.
Chromosome 8 (mouse)
Genomic location for PCM1
Genomic location for PCM1
Band
bp
bp
RNA expression
Bgee
Human
Mouse
Top expressed in
BioGPS


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