242:
219:
116:
141:
248:
147:
1616:
255:
154:
1099:
Mbikay M, Seidah NG, Chretien M, Simpson EM (Jul 1995). "Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human".
1434:"The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment"
727:
708:
77:
1309:"DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III"
1153:
Seidah NG, Chrétien M, Day R (1995). "The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions".
1685:
1661:
1680:
1081:
1063:
1182:
Bassi DE, Mahloogi H, Klein-Szanto AJ (2000). "The proprotein convertases furin and PACE4 play a significant role in tumor progression".
241:
938:
218:
931:
1134:
1050:
1029:
140:
115:
1342:
Li M, Mbikay M, Nakayama K, et al. (2001). "Prohormone convertase PC4 processes the precursor of PACAP in the testis".
1046:
1195:
1025:
57:
254:
153:
1654:
247:
146:
772:
65:
1512:"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"
753:
1647:
129:
1566:
1392:
1267:
44:
846:
1367:
1207:
89:
1381:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
914:
893:
867:
842:
1594:
1541:
1498:
1463:
1420:
1359:
1330:
1295:
1242:
1199:
1170:
1116:
37:
1584:
1574:
1531:
1523:
1488:
1453:
1445:
1410:
1400:
1351:
1320:
1285:
1275:
1232:
1191:
1162:
1108:
334:
265:
209:
164:
85:
309:
1555:"Role of pro-IGF-II processing by proprotein convertase 4 in human placental development"
1570:
1396:
1271:
1631:
1589:
1554:
1355:
1536:
1511:
1458:
1433:
1415:
1380:
1325:
1308:
642:
637:
632:
627:
622:
617:
612:
607:
591:
586:
581:
576:
571:
566:
561:
545:
540:
535:
530:
525:
1674:
1627:
1290:
1255:
1166:
1112:
512:
1371:
1211:
327:
106:
69:
1256:"A dynamic model for PC4 coactivator function in RNA polymerase II transcription"
93:
1086:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1068:
National Center for
Biotechnology Information, U.S. National Library of Medicine
410:
226:
123:
73:
1579:
1477:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
1221:"Normalization and subtraction: two approaches to facilitate gene discovery"
672:
470:
348:
293:
280:
192:
179:
81:
1598:
1545:
1502:
1467:
1424:
1405:
1363:
1280:
1203:
1334:
1299:
1246:
1174:
1120:
978:
973:
962:
817:
798:
1527:
1449:
1237:
1220:
784:
739:
994:
946:
694:
1615:
1493:
1476:
1135:"Entrez Gene: PCSK4 proprotein convertase subtilisin/kexin type 4"
657:
653:
1623:
1196:
10.1002/1098-2744(200006)28:2<63::AID-MC1>3.0.CO;2-C
1001:
61:
1379:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
48:, PC4, SPC5, proprotein convertase subtilisin/kexin type 4
317:
1635:
1510:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
482:
907:
886:
860:
835:
1475:Ota T, Suzuki Y, Nishikawa T, et al. (2004).
1432:Clark HF, Gurney AL, Abaya E, et al. (2003).
1042:
1040:
1038:
1021:
1019:
1017:
264:
163:
16:Protein-coding gene in the species Homo sapiens
1553:Qiu Q, Basak A, Mbikay M, et al. (2005).
1047:GRCm38: Ensembl release 89: ENSMUSG00000020131
1655:
991:Proprotein convertase subtilisin/kexin type 4
8:
1026:GRCh38: Ensembl release 89: ENSG00000115257
1662:
1648:
668:
508:
305:
204:
101:
1588:
1578:
1535:
1492:
1457:
1414:
1404:
1324:
1289:
1279:
1236:
1219:Bonaldo MF, Lennon G, Soares MB (1997).
1013:
1254:Malik S, Guermah M, Roeder RG (1998).
18:
269:
230:
225:
168:
127:
122:
7:
1612:
1610:
592:integral component of Golgi membrane
1356:10.1111/j.1749-6632.2000.tb06988.x
904:
883:
857:
832:
808:
789:
763:
744:
718:
699:
613:binding of sperm to zona pellucida
546:serine-type endopeptidase activity
487:
405:
343:
322:
14:
997:that in humans is encoded by the
1614:
253:
246:
240:
217:
152:
145:
139:
114:
1686:Human chromosome 19 gene stubs
562:integral component of membrane
531:serine-type peptidase activity
471:More reference expression data
395:olfactory zone of nasal mucosa
1:
1326:10.1016/S1097-2765(00)80074-X
238:
137:
1681:Genes on human chromosome 19
1634:. You can help Knowledge by
1559:Proc. Natl. Acad. Sci. U.S.A
1385:Proc. Natl. Acad. Sci. U.S.A
1260:Proc. Natl. Acad. Sci. U.S.A
1167:10.1016/0300-9084(94)90147-3
1113:10.1016/0888-7543(95)80090-9
387:right lobe of thyroid gland
1702:
1609:
1307:Wang Z, Roeder RG (1998).
643:peptide hormone processing
391:left lobe of thyroid gland
1082:"Mouse PubMed Reference:"
1064:"Human PubMed Reference:"
977:
972:
968:
961:
945:
926:
911:
890:
879:
864:
839:
828:
815:
811:
796:
792:
783:
770:
766:
751:
747:
738:
725:
721:
706:
702:
693:
678:
671:
667:
651:
511:
507:
495:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
939:Chr 10: 80.32 – 80.33 Mb
1580:10.1073/pnas.0502357102
437:external carotid artery
433:internal carotid artery
1406:10.1073/pnas.242603899
1281:10.1073/pnas.95.5.2192
932:Chr 19: 1.48 – 1.49 Mb
441:neural layer of retina
271:10 C1|10 39.72 cM
232:Chromosome 10 (mouse)
130:Chromosome 19 (human)
1344:Ann. N. Y. Acad. Sci
633:reproductive process
1571:2005PNAS..10211047Q
1397:2002PNAS...9916899M
1272:1998PNAS...95.2192M
587:trans-Golgi network
577:cytoplasmic vesicle
445:outer nuclear layer
429:seminiferous tubule
379:right lobe of liver
1622:This article on a
1528:10.1101/gr.2596504
1450:10.1101/gr.1293003
1238:10.1101/gr.6.9.791
773:ENSMUSG00000020131
638:protein processing
618:sperm capacitation
601:Biological process
572:acrosomal membrane
555:Cellular component
536:hydrolase activity
526:peptidase activity
519:Molecular function
383:right frontal lobe
375:anterior pituitary
367:right uterine tube
1643:
1642:
1391:(26): 16899–903.
988:
987:
984:
983:
957:
956:
922:
921:
901:
900:
875:
874:
854:
853:
824:
823:
805:
804:
779:
778:
760:
759:
734:
733:
715:
714:
663:
662:
623:acrosome reaction
582:acrosomal vesicle
503:
502:
499:
498:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
94:PCSK4 - orthologs
1693:
1664:
1657:
1650:
1618:
1611:
1602:
1592:
1582:
1565:(31): 11047–52.
1549:
1539:
1506:
1496:
1471:
1461:
1428:
1418:
1408:
1375:
1338:
1328:
1303:
1293:
1283:
1250:
1240:
1215:
1178:
1161:(3–4): 197–209.
1139:
1138:
1131:
1125:
1124:
1096:
1090:
1089:
1078:
1072:
1071:
1060:
1054:
1044:
1033:
1023:
970:
969:
941:
934:
917:
905:
896:
884:
880:RefSeq (protein)
870:
858:
849:
833:
809:
790:
764:
745:
719:
700:
669:
509:
488:
473:
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1701:
1700:
1696:
1695:
1694:
1692:
1691:
1690:
1671:
1670:
1669:
1668:
1607:
1605:
1552:
1522:(10B): 2121–7.
1509:
1474:
1444:(10): 2265–70.
1431:
1378:
1341:
1306:
1253:
1218:
1181:
1152:
1148:
1146:Further reading
1143:
1142:
1133:
1132:
1128:
1098:
1097:
1093:
1080:
1079:
1075:
1062:
1061:
1057:
1045:
1036:
1024:
1015:
1010:
979:View/Edit Mouse
974:View/Edit Human
937:
930:
927:Location (UCSC)
913:
892:
866:
845:
841:
754:ENSG00000115257
647:
596:
550:
541:protein binding
469:
460:
455:
453:proximal tubule
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1699:
1697:
1689:
1688:
1683:
1673:
1672:
1667:
1666:
1659:
1652:
1644:
1641:
1640:
1619:
1604:
1603:
1550:
1507:
1494:10.1038/ng1285
1472:
1429:
1376:
1339:
1304:
1251:
1231:(9): 791–806.
1216:
1179:
1149:
1147:
1144:
1141:
1140:
1126:
1091:
1073:
1055:
1034:
1012:
1011:
1009:
1006:
986:
985:
982:
981:
976:
966:
965:
959:
958:
955:
954:
952:
950:
943:
942:
935:
928:
924:
923:
920:
919:
909:
908:
902:
899:
898:
888:
887:
881:
877:
876:
873:
872:
862:
861:
855:
852:
851:
837:
836:
830:
826:
825:
822:
821:
813:
812:
806:
803:
802:
794:
793:
787:
781:
780:
777:
776:
768:
767:
761:
758:
757:
749:
748:
742:
736:
735:
732:
731:
723:
722:
716:
713:
712:
704:
703:
697:
691:
690:
685:
680:
676:
675:
665:
664:
661:
660:
649:
648:
646:
645:
640:
635:
630:
625:
620:
615:
610:
604:
602:
598:
597:
595:
594:
589:
584:
579:
574:
569:
564:
558:
556:
552:
551:
549:
548:
543:
538:
533:
528:
522:
520:
516:
515:
505:
504:
501:
500:
497:
496:
493:
492:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1698:
1687:
1684:
1682:
1679:
1678:
1676:
1665:
1660:
1658:
1653:
1651:
1646:
1645:
1639:
1637:
1633:
1629:
1628:chromosome 19
1625:
1620:
1617:
1613:
1608:
1600:
1596:
1591:
1586:
1581:
1576:
1572:
1568:
1564:
1560:
1556:
1551:
1547:
1543:
1538:
1533:
1529:
1525:
1521:
1517:
1513:
1508:
1504:
1500:
1495:
1490:
1486:
1482:
1478:
1473:
1469:
1465:
1460:
1455:
1451:
1447:
1443:
1439:
1435:
1430:
1426:
1422:
1417:
1412:
1407:
1402:
1398:
1394:
1390:
1386:
1382:
1377:
1373:
1369:
1365:
1361:
1357:
1353:
1349:
1345:
1340:
1336:
1332:
1327:
1322:
1319:(5): 749–57.
1318:
1314:
1310:
1305:
1301:
1297:
1292:
1287:
1282:
1277:
1273:
1269:
1266:(5): 2192–7.
1265:
1261:
1257:
1252:
1248:
1244:
1239:
1234:
1230:
1226:
1222:
1217:
1213:
1209:
1205:
1201:
1197:
1193:
1189:
1185:
1184:Mol. Carcinog
1180:
1176:
1172:
1168:
1164:
1160:
1156:
1151:
1150:
1145:
1136:
1130:
1127:
1122:
1118:
1114:
1110:
1106:
1102:
1095:
1092:
1087:
1083:
1077:
1074:
1069:
1065:
1059:
1056:
1052:
1048:
1043:
1041:
1039:
1035:
1031:
1027:
1022:
1020:
1018:
1014:
1007:
1005:
1003:
1000:
996:
992:
980:
975:
971:
967:
964:
960:
953:
951:
948:
944:
940:
936:
933:
929:
925:
918:
916:
910:
906:
903:
897:
895:
889:
885:
882:
878:
871:
869:
863:
859:
856:
850:
848:
844:
838:
834:
831:
829:RefSeq (mRNA)
827:
820:
819:
814:
810:
807:
801:
800:
795:
791:
788:
786:
782:
775:
774:
769:
765:
762:
756:
755:
750:
746:
743:
741:
737:
730:
729:
724:
720:
717:
711:
710:
705:
701:
698:
696:
692:
689:
686:
684:
681:
677:
674:
670:
666:
659:
655:
650:
644:
641:
639:
636:
634:
631:
629:
628:fertilization
626:
624:
621:
619:
616:
614:
611:
609:
606:
605:
603:
600:
599:
593:
590:
588:
585:
583:
580:
578:
575:
573:
570:
568:
565:
563:
560:
559:
557:
554:
553:
547:
544:
542:
539:
537:
534:
532:
529:
527:
524:
523:
521:
518:
517:
514:
513:Gene ontology
510:
506:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1636:expanding it
1621:
1606:
1562:
1558:
1519:
1515:
1484:
1480:
1441:
1437:
1388:
1384:
1347:
1343:
1316:
1312:
1263:
1259:
1228:
1224:
1187:
1183:
1158:
1154:
1129:
1107:(1): 123–9.
1104:
1100:
1094:
1085:
1076:
1067:
1058:
998:
990:
989:
912:
891:
865:
847:NM_001395257
840:
816:
797:
771:
752:
726:
707:
687:
682:
425:spermatocyte
363:right testis
333:
326:
53:External IDs
1487:(1): 40–5.
1190:(2): 63–9.
608:proteolysis
359:left testis
292:80,329,498
279:80,321,283
31:Identifiers
1675:Categories
1516:Genome Res
1481:Nat. Genet
1438:Genome Res
1225:Genome Res
1053:, May 2017
1032:, May 2017
1008:References
337:(ortholog)
191:1,490,752
178:1,481,428
74:HomoloGene
1626:on human
1350:: 333–9.
1313:Mol. Cell
1155:Biochimie
915:NP_032819
894:NP_060043
868:NM_008793
843:NM_017573
673:Orthologs
421:spermatid
82:GeneCards
1599:16040806
1546:15489334
1503:14702039
1468:12975309
1425:12477932
1372:46125753
1364:11193847
1212:22849623
1204:10900462
1101:Genomics
1049:–
1028:–
963:Wikidata
652:Sources:
567:membrane
371:testicle
1590:1182422
1567:Bibcode
1393:Bibcode
1335:9660958
1300:9482861
1268:Bibcode
1247:8889548
1175:7819324
1121:7782070
1051:Ensembl
1030:Ensembl
785:UniProt
740:Ensembl
679:Species
658:QuickGO
312:pattern
170:19p13.3
38:Aliases
1597:
1587:
1544:
1537:528928
1534:
1501:
1466:
1459:403697
1456:
1423:
1416:139241
1413:
1370:
1362:
1333:
1298:
1288:
1245:
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1173:
1119:
995:enzyme
993:is an
949:search
947:PubMed
818:P29121
799:Q6UW60
695:Entrez
483:BioGPS
457:embryo
449:embryo
62:600487
1630:is a
1368:S2CID
1291:19292
1208:S2CID
999:PCSK4
728:18551
709:54760
688:Mouse
683:Human
654:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
86:PCSK4
78:22495
70:97514
45:PCSK4
22:PCSK4
1632:stub
1624:gene
1595:PMID
1542:PMID
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1421:PMID
1360:PMID
1331:PMID
1296:PMID
1243:PMID
1200:PMID
1171:PMID
1117:PMID
1002:gene
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
1585:PMC
1575:doi
1563:102
1532:PMC
1524:doi
1489:doi
1454:PMC
1446:doi
1411:PMC
1401:doi
1352:doi
1348:921
1321:doi
1286:PMC
1276:doi
1233:doi
1192:doi
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1109:doi
491:n/a
288:End
187:End
90:OMA
66:MGI
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