242:
219:
116:
141:
493:
248:
147:
1799:
1008:
This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24,
1609:"Molecular analysis of an unstable genomic region at chromosome band 11q23 reveals a disruption of the gene encoding the alpha2 subunit of platelet-activating factor acetylhydrolase (Pafah1a2) in human lymphoma"
988:
convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine
1685:
Bhattacharjya S, Xu P, Zhong M, et al. (2000). "Inhibitory activity and structural characterization of a C-terminal peptide fragment derived from the prosegment of the proprotein convertase PC7".
1285:
Tsuji A, Hine C, Mori K, et al. (1994). "A novel member, PC7, of the mammalian kexin-like protease family: homology to PACE4A, its brain-specific expression and identification of isoforms".
1644:"Occurrence of an HIV-1 gp160 endoproteolytic activity in low-density vesicles and evidence for a distinct density distribution from endogenously expressed furin and PC7/LPC convertases"
1343:
Meerabux J, Yaspo ML, Roebroek AJ, et al. (1996). "A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas".
1578:
Mori K, Imamaki A, Nagata K, et al. (1999). "Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells".
255:
154:
1520:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
696:
77:
677:
1751:"A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex"
1549:
Moulard M, Chaloin L, Canarelli S, et al. (1998). "Retroviral envelope glycoprotein processing: structural investigation of the cleavage site".
1227:
Seidah NG, Chrétien M, Day R (1995). "The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions".
1868:
1366:"Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines"
1844:
997:
network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of
1863:
1401:"The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells"
1094:
1076:
1314:
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
904:
241:
911:
218:
1205:
1063:
1042:
140:
115:
1487:"Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase"
1059:
1038:
1716:"Binding of BiP to the processing enzyme lymphoma proprotein convertase prevents aggregation, but slows down maturation"
57:
998:
254:
153:
1837:
247:
146:
741:
65:
1013:
that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with
993:. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-
1256:
Moulard M, Decroly E (2001). "Maturation of HIV envelope glycoprotein precursors by cellular endoproteases".
1112:
Bruzzaniti A, Goodge K, Jay P, Taviaux SA, Lam MH, Berta P, Martin TJ, Moseley JM, Gillespie MT (Jun 1996).
722:
1830:
129:
1444:"Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160"
44:
883:
832:
1780:
1673:
1473:
89:
887:
862:
836:
811:
1772:
1737:
1702:
1665:
1630:
1595:
1566:
1537:
1508:
1465:
1430:
1387:
1352:
1331:
1302:
1273:
1244:
1184:
1139:
37:
1762:
1727:
1694:
1655:
1620:
1587:
1558:
1529:
1498:
1455:
1420:
1412:
1377:
1323:
1294:
1265:
1236:
1174:
1166:
1129:
1121:
334:
265:
209:
164:
492:
85:
1591:
994:
309:
1814:
1179:
1158:
1134:
1113:
1767:
1750:
1660:
1643:
1533:
1460:
1443:
1425:
1400:
1269:
611:
606:
601:
585:
580:
575:
570:
565:
549:
544:
539:
534:
1857:
1810:
1327:
1240:
521:
1784:
1477:
1416:
1677:
990:
327:
106:
69:
93:
1099:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1081:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1010:
1159:"Gene organization and alternative splicing of human prohormone convertase PC8"
410:
985:
981:
226:
123:
73:
1503:
1486:
1382:
1365:
641:
470:
348:
293:
280:
192:
179:
81:
1776:
1741:
1732:
1715:
1706:
1669:
1634:
1625:
1608:
1599:
1298:
1277:
1570:
1541:
1512:
1469:
1434:
1391:
1356:
1335:
1306:
1248:
1188:
1143:
951:
946:
1014:
935:
786:
767:
753:
708:
1698:
1562:
1170:
1125:
967:
919:
663:
1798:
48:, LPC, PC7, PC8, SPC7, proprotein convertase subtilisin/kexin type 7
1206:"Entrez Gene: PCSK7 proprotein convertase subtilisin/kexin type 7"
1002:
626:
622:
1806:
974:
61:
501:
1642:
Wouters S, Decroly E, Vandenbranden M, et al. (1999).
1485:
van de Loo JW, Creemers JW, Bright NA, et al. (1997).
1157:
Goodge KA, Thomas RJ, Martin TJ, Gillespie MT (Jan 1999).
1714:
Creemers JW, van de Loo JW, Plets E, et al. (2001).
1399:
Hallenberger S, Moulard M, Sordel M, et al. (1997).
317:
1818:
1607:
Lecointe N, Meerabux J, Ebihara M, et al. (1999).
1017:
occurs between this gene and its inverted counterpart.
1364:
Decroly E, Wouters S, Di Bello C, et al. (1997).
1442:
Decroly E, Benjannet S, Savaria D, Seidah NG (1997).
482:
876:
855:
825:
804:
1055:
1053:
1051:
1034:
1032:
1030:
264:
163:
980:The protein encoded by this gene belongs to the
16:Protein-coding gene in the species Homo sapiens
1749:Grosset C, Chen CY, Xu N, et al. (2000).
1060:GRCm38: Ensembl release 89: ENSMUSG00000035382
1838:
964:Proprotein convertase subtilisin/kexin type 7
8:
1114:"C8, a new member of the convertase family"
1039:GRCh38: Ensembl release 89: ENSG00000160613
1845:
1831:
637:
517:
305:
204:
101:
1766:
1731:
1659:
1624:
1502:
1459:
1424:
1381:
1178:
1133:
1200:
1198:
1026:
18:
1592:10.1093/oxfordjournals.jbchem.a022329
269:
230:
225:
168:
127:
122:
7:
1795:
1793:
571:integral component of Golgi membrane
873:
852:
822:
801:
777:
758:
732:
713:
687:
668:
550:serine-type endopeptidase activity
487:
405:
343:
322:
14:
970:that in humans is encoded by the
1797:
491:
253:
246:
240:
217:
152:
145:
139:
114:
1417:10.1128/JVI.71.2.1036-1045.1997
1869:Human chromosome 11 gene stubs
1120:. 314 ( Pt 3) (Pt 3): 727–31.
566:integral component of membrane
540:serine-type peptidase activity
502:More reference expression data
471:More reference expression data
1:
1768:10.1016/S0092-8674(00)00102-1
1661:10.1016/S0014-5793(99)00938-2
1534:10.1016/S0378-1119(97)00411-3
1461:10.1016/S0014-5793(97)00156-7
1287:Biochem. Biophys. Res. Commun
1270:10.1016/S0304-4157(00)00014-9
1165:. 336 ( Pt 2) (Pt 2): 353–9.
238:
137:
1864:Genes on human chromosome 11
1817:. You can help Knowledge by
1328:10.1016/0378-1119(94)90802-8
1241:10.1016/0300-9084(94)90147-3
1885:
1792:
607:peptide hormone processing
367:mucosa of transverse colon
1095:"Mouse PubMed Reference:"
1077:"Human PubMed Reference:"
950:
945:
941:
934:
918:
905:Chr 11: 117.2 – 117.23 Mb
899:
880:
859:
848:
829:
808:
797:
784:
780:
765:
761:
752:
739:
735:
720:
716:
707:
694:
690:
675:
671:
662:
647:
640:
636:
620:
520:
516:
499:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1504:10.1074/jbc.272.43.27116
1383:10.1074/jbc.271.48.30442
912:Chr 9: 45.82 – 45.84 Mb
1733:10.1074/jbc.M006758200
1626:10.1038/sj.onc.1202645
1299:10.1006/bbrc.1994.2094
1258:Biochim. Biophys. Acta
425:neural layer of retina
271:9 A5.2|9 25.32 cM
449:epithelium of stomach
130:Chromosome 11 (human)
232:Chromosome 9 (mouse)
586:trans-Golgi network
445:submandibular gland
383:epithelium of colon
1805:This article on a
742:ENSMUSG00000035382
602:protein processing
595:Biological process
559:Cellular component
545:hydrolase activity
535:peptidase activity
528:Molecular function
387:buccal mucosa cell
1826:
1825:
1699:10.1021/bi9923961
1563:10.1021/bi972662f
1171:10.1042/bj3360353
1126:10.1042/bj3140727
961:
960:
957:
956:
930:
929:
895:
894:
870:
869:
844:
843:
819:
818:
793:
792:
774:
773:
748:
747:
729:
728:
703:
702:
684:
683:
632:
631:
512:
511:
508:
507:
477:
476:
464:
463:
402:
401:
375:left uterine tube
300:
299:
199:
198:
94:PCSK7 - orthologs
1876:
1847:
1840:
1833:
1801:
1794:
1788:
1770:
1745:
1735:
1710:
1681:
1663:
1638:
1628:
1603:
1574:
1545:
1516:
1506:
1497:(43): 27116–23.
1481:
1463:
1438:
1428:
1395:
1385:
1376:(48): 30442–50.
1360:
1339:
1310:
1281:
1252:
1235:(3–4): 197–209.
1210:
1209:
1202:
1193:
1192:
1182:
1154:
1148:
1147:
1137:
1109:
1103:
1102:
1091:
1085:
1084:
1073:
1067:
1057:
1046:
1036:
943:
942:
914:
907:
890:
874:
865:
853:
849:RefSeq (protein)
839:
823:
814:
802:
778:
759:
733:
714:
688:
669:
638:
518:
504:
495:
488:
473:
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1884:
1883:
1879:
1878:
1877:
1875:
1874:
1873:
1854:
1853:
1852:
1851:
1791:
1748:
1726:(49): 38842–7.
1713:
1693:(11): 2868–77.
1684:
1641:
1606:
1577:
1548:
1528:(1–2): 149–56.
1519:
1484:
1441:
1398:
1363:
1342:
1313:
1284:
1255:
1226:
1222:
1220:Further reading
1214:
1213:
1204:
1203:
1196:
1156:
1155:
1151:
1111:
1110:
1106:
1093:
1092:
1088:
1075:
1074:
1070:
1058:
1049:
1037:
1028:
1023:
952:View/Edit Mouse
947:View/Edit Human
910:
903:
900:Location (UCSC)
886:
882:
861:
835:
831:
810:
723:ENSG00000160613
616:
590:
576:Golgi apparatus
554:
500:
469:
460:
455:
451:
447:
443:
439:
435:
433:large intestine
431:
427:
423:
409:
398:
393:
389:
385:
381:
379:body of stomach
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1882:
1880:
1872:
1871:
1866:
1856:
1855:
1850:
1849:
1842:
1835:
1827:
1824:
1823:
1802:
1790:
1789:
1746:
1711:
1682:
1639:
1619:(18): 2852–9.
1604:
1575:
1557:(13): 4510–7.
1546:
1517:
1482:
1439:
1411:(2): 1036–45.
1396:
1361:
1340:
1322:(1–2): 171–4.
1311:
1282:
1253:
1223:
1221:
1218:
1212:
1211:
1194:
1149:
1104:
1086:
1068:
1047:
1025:
1024:
1022:
1019:
1001:glycoproteins
959:
958:
955:
954:
949:
939:
938:
932:
931:
928:
927:
925:
923:
916:
915:
908:
901:
897:
896:
893:
892:
878:
877:
871:
868:
867:
857:
856:
850:
846:
845:
842:
841:
827:
826:
820:
817:
816:
806:
805:
799:
795:
794:
791:
790:
782:
781:
775:
772:
771:
763:
762:
756:
750:
749:
746:
745:
737:
736:
730:
727:
726:
718:
717:
711:
705:
704:
701:
700:
692:
691:
685:
682:
681:
673:
672:
666:
660:
659:
654:
649:
645:
644:
634:
633:
630:
629:
618:
617:
615:
614:
609:
604:
598:
596:
592:
591:
589:
588:
583:
578:
573:
568:
562:
560:
556:
555:
553:
552:
547:
542:
537:
531:
529:
525:
524:
514:
513:
510:
509:
506:
505:
497:
496:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
371:gastric mucosa
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1881:
1870:
1867:
1865:
1862:
1861:
1859:
1848:
1843:
1841:
1836:
1834:
1829:
1828:
1822:
1820:
1816:
1812:
1811:chromosome 11
1808:
1803:
1800:
1796:
1786:
1782:
1778:
1774:
1769:
1764:
1760:
1756:
1752:
1747:
1743:
1739:
1734:
1729:
1725:
1721:
1720:J. Biol. Chem
1717:
1712:
1708:
1704:
1700:
1696:
1692:
1688:
1683:
1679:
1675:
1671:
1667:
1662:
1657:
1654:(1): 97–102.
1653:
1649:
1645:
1640:
1636:
1632:
1627:
1622:
1618:
1614:
1610:
1605:
1601:
1597:
1593:
1589:
1586:(3): 627–33.
1585:
1581:
1576:
1572:
1568:
1564:
1560:
1556:
1552:
1547:
1543:
1539:
1535:
1531:
1527:
1523:
1518:
1514:
1510:
1505:
1500:
1496:
1492:
1491:J. Biol. Chem
1488:
1483:
1479:
1475:
1471:
1467:
1462:
1457:
1453:
1449:
1445:
1440:
1436:
1432:
1427:
1422:
1418:
1414:
1410:
1406:
1402:
1397:
1393:
1389:
1384:
1379:
1375:
1371:
1370:J. Biol. Chem
1367:
1362:
1358:
1354:
1351:(3): 448–51.
1350:
1346:
1341:
1337:
1333:
1329:
1325:
1321:
1317:
1312:
1308:
1304:
1300:
1296:
1293:(3): 1452–9.
1292:
1288:
1283:
1279:
1275:
1271:
1267:
1264:(3): 121–32.
1263:
1259:
1254:
1250:
1246:
1242:
1238:
1234:
1230:
1225:
1224:
1219:
1217:
1207:
1201:
1199:
1195:
1190:
1186:
1181:
1176:
1172:
1168:
1164:
1160:
1153:
1150:
1145:
1141:
1136:
1131:
1127:
1123:
1119:
1115:
1108:
1105:
1100:
1096:
1090:
1087:
1082:
1078:
1072:
1069:
1065:
1061:
1056:
1054:
1052:
1048:
1044:
1040:
1035:
1033:
1031:
1027:
1020:
1018:
1016:
1012:
1006:
1004:
1000:
996:
992:
987:
983:
978:
976:
973:
969:
965:
953:
948:
944:
940:
937:
933:
926:
924:
921:
917:
913:
909:
906:
902:
898:
891:
889:
885:
879:
875:
872:
866:
864:
858:
854:
851:
847:
840:
838:
834:
828:
824:
821:
815:
813:
807:
803:
800:
798:RefSeq (mRNA)
796:
789:
788:
783:
779:
776:
770:
769:
764:
760:
757:
755:
751:
744:
743:
738:
734:
731:
725:
724:
719:
715:
712:
710:
706:
699:
698:
693:
689:
686:
680:
679:
674:
670:
667:
665:
661:
658:
655:
653:
650:
646:
643:
639:
635:
628:
624:
619:
613:
610:
608:
605:
603:
600:
599:
597:
594:
593:
587:
584:
582:
579:
577:
574:
572:
569:
567:
564:
563:
561:
558:
557:
551:
548:
546:
543:
541:
538:
536:
533:
532:
530:
527:
526:
523:
522:Gene ontology
519:
515:
503:
498:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
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378:
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345:
342:
341:
338:
336:
332:
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295:
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286:
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206:
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194:
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135:
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125:
121:
117:
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71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1819:expanding it
1804:
1761:(1): 29–40.
1758:
1754:
1723:
1719:
1690:
1687:Biochemistry
1686:
1651:
1647:
1616:
1612:
1583:
1579:
1554:
1551:Biochemistry
1550:
1525:
1521:
1494:
1490:
1454:(1): 68–72.
1451:
1447:
1408:
1404:
1373:
1369:
1348:
1344:
1319:
1315:
1290:
1286:
1261:
1257:
1232:
1228:
1215:
1162:
1152:
1117:
1107:
1098:
1089:
1080:
1071:
1007:
1005:and gp140.
999:HIV envelope
991:endoprotease
979:
971:
963:
962:
884:NP_001268863
881:
860:
833:NM_001281934
830:
809:
785:
766:
740:
721:
695:
676:
656:
651:
437:right kidney
429:spermatocyte
333:
326:
191:117,232,525
178:117,204,337
53:External IDs
1011:nucleotides
612:proteolysis
421:granulocyte
363:sural nerve
359:granulocyte
292:45,841,024
279:45,817,795
31:Identifiers
1858:Categories
1580:J. Biochem
1345:Cancer Res
1066:, May 2017
1045:, May 2017
1021:References
986:proprotein
982:subtilisin
391:lymph node
337:(ortholog)
74:HomoloGene
1809:on human
1648:FEBS Lett
1448:FEBS Lett
1229:Biochimie
1163:Biochem J
1118:Biochem J
888:NP_032820
863:NP_004707
837:NM_008794
812:NM_004716
642:Orthologs
82:GeneCards
1785:18135412
1777:11051545
1742:10964928
1707:10715106
1670:10452538
1635:10362256
1613:Oncogene
1600:10050053
1478:40785575
1405:J. Virol
1278:11063880
1062:–
1041:–
1015:lymphoma
936:Wikidata
621:Sources:
581:membrane
1678:7796014
1571:9521771
1542:9373149
1513:9341152
1470:9094426
1435:8995623
1392:8940009
1357:8564950
1336:8125298
1307:8060327
1249:7819324
1189:9820811
1180:1219878
1144:8615762
1135:1217117
1064:Ensembl
1043:Ensembl
754:UniProt
709:Ensembl
648:Species
627:QuickGO
312:pattern
170:11q23.3
38:Aliases
1783:
1775:
1740:
1705:
1676:
1668:
1633:
1598:
1569:
1540:
1511:
1476:
1468:
1433:
1426:191154
1423:
1390:
1355:
1334:
1305:
1276:
1247:
1187:
1177:
1142:
1132:
984:-like
968:enzyme
966:is an
922:search
920:PubMed
787:Q61139
768:Q16549
664:Entrez
483:BioGPS
457:thymus
395:rectum
70:107421
62:604872
1813:is a
1781:S2CID
1674:S2CID
1474:S2CID
1003:gp160
995:Golgi
972:PCSK7
697:18554
657:Mouse
652:Human
623:Amigo
441:colon
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
86:PCSK7
78:37955
45:PCSK7
22:PCSK7
1815:stub
1807:gene
1773:PMID
1755:Cell
1738:PMID
1703:PMID
1666:PMID
1631:PMID
1596:PMID
1567:PMID
1538:PMID
1522:Gene
1509:PMID
1466:PMID
1431:PMID
1388:PMID
1353:PMID
1332:PMID
1316:Gene
1303:PMID
1274:PMID
1262:1469
1245:PMID
1185:PMID
1140:PMID
975:gene
678:9159
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
1763:doi
1759:103
1728:doi
1724:275
1695:doi
1656:doi
1652:456
1621:doi
1588:doi
1584:125
1559:doi
1530:doi
1526:200
1499:doi
1495:272
1456:doi
1452:405
1421:PMC
1413:doi
1378:doi
1374:271
1324:doi
1320:138
1295:doi
1291:202
1266:doi
1237:doi
1175:PMC
1167:doi
1130:PMC
1122:doi
453:lip
288:End
187:End
90:OMA
66:MGI
1860::
1779:.
1771:.
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1347:.
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1301:.
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1233:76
1231:.
1216:]
1197:^
1183:.
1173:.
1161:.
1138:.
1128:.
1116:.
1097:.
1079:.
1050:^
1029:^
977:.
625:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
1846:e
1839:t
1832:v
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92::
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