318:
295:
192:
217:
583:
576:
569:
1889:
324:
223:
29:
5351:
1479:
family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha
55:
1817:
Kurup S, Abramsson A, Li JP, Lindahl U, Kjellen L, Betsholtz C, Gerhardt H, Spillmann D (2006). "Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment".
2419:
331:
230:
4334:
2412:
5294:
4950:
4098:
3715:
2405:
1186:
153:
1167:
3773:
1888:
4635:
4325:
1929:
1521:. This fusion gene greatly overproduces PDGFB and is considered responsible for causing the development and/or progression of three closely related
5425:
3930:
1522:
5396:
2915:
2598:
2154:
5415:
5313:
5263:
5234:
5181:
3668:
3535:
1868:
1633:
1615:
4992:
4988:
4984:
4980:
2533:
2517:
2355:
2350:
2345:
317:
3261:
3180:
3047:
2964:
4976:
2337:
1394:
1401:
294:
4665:
3784:
3344:
2955:
1957:
2613:
2557:
2548:
1798:
5187:
2243:
2172:
1602:
1581:
1534:
1530:
977:
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
5274:
5250:
4390:
3946:
3809:
2304:
1972:
1553:
1476:
216:
191:
1598:
52:
5240:
1700:
Clements JM, Bawden LJ, Bloxidge RE, Catlin G, Cook AL, Craig S, Drummond AH, Edwards RM, Fallon A, Green DR (Jan 1992).
1577:
5284:
3680:
3562:
3552:
2231:
2226:
1922:
133:
4630:
2360:
2122:
4655:
330:
229:
1799:"Entrez Gene: PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)"
5389:
5269:
3095:
2216:
2199:
2164:
2001:
4650:
323:
222:
5177:
1861:
3361:
3277:
3196:
3063:
2980:
2386:
1946:
1526:
1231:
141:
2795:
1653:"Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor"
5420:
4961:
2708:
2583:
2365:
2149:
1915:
1212:
4640:
5245:
4861:
4765:
4625:
4385:
3804:
2790:
2428:
5382:
5319:
3516:
3160:
2800:
2439:
205:
5259:
4645:
3577:
3526:
1854:
4395:
2470:
120:
4400:
3814:
3511:
2703:
2381:
1702:"Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation"
3436:
5018:
4931:
4876:
4830:
4775:
4510:
4450:
4078:
3451:
3381:
2940:
2538:
2480:
2431:
165:
5013:
4891:
4790:
4576:
4465:
4265:
4225:
3973:
3892:
3754:
3695:
3657:
3602:
3597:
3587:
3461:
3456:
3426:
3401:
3396:
3386:
3272:
3191:
3130:
3058:
3037:
3022:
2975:
2628:
1377:
1356:
1352:
1326:
1305:
1301:
5113:
4971:
4906:
4886:
4805:
4785:
4500:
4480:
4460:
4103:
3431:
3155:
2688:
2485:
4936:
4926:
4881:
4835:
4825:
4780:
4705:
4604:
4571:
4551:
4515:
4505:
4455:
4415:
3887:
3867:
3834:
3617:
3466:
1834:
1780:
1731:
1682:
582:
575:
113:
45:
5366:
4896:
4795:
4690:
4594:
4546:
4539:
4525:
4470:
4440:
3920:
3910:
3862:
3844:
3607:
3446:
3391:
5123:
4255:
1826:
1770:
1762:
1751:"Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck"
1721:
1713:
1672:
1664:
410:
341:
285:
240:
3647:
568:
161:
4735:
2283:
2278:
2136:
1507:
385:
5309:
5230:
5172:
4866:
4715:
4710:
3824:
3819:
2465:
2455:
2450:
1775:
1750:
1717:
28:
1726:
1701:
1677:
1652:
1101:
1096:
1091:
1086:
1081:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
624:
5409:
5362:
5003:
4916:
4845:
4815:
4750:
4660:
4614:
4490:
4420:
4365:
4354:
3839:
3547:
3230:
3135:
3027:
1938:
1092:
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
611:
2397:
5329:
5299:
5038:
5028:
4921:
4820:
4675:
4495:
4430:
4345:
3849:
3652:
3491:
3486:
3406:
3356:
3170:
2924:
2905:
2884:
2855:
2578:
2573:
403:
182:
1506:
genes are respectively located or, alternatively, an abnormal small supernumerary
145:
169:
124:, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet derived growth factor subunit B
5289:
5255:
5153:
5143:
5138:
5128:
5078:
4901:
4800:
4561:
4475:
4405:
4300:
4063:
4028:
3978:
3941:
3877:
3759:
3690:
3642:
3632:
3627:
3622:
3506:
3501:
3496:
2874:
2785:
2775:
2743:
2738:
2733:
2728:
2718:
2678:
2643:
1638:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1620:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1518:
1017:
positive regulation of cyclin-dependent protein serine/threonine kinase activity
1766:
1077:
positive regulation of vascular associated smooth muscle cell dedifferentiation
486:
5108:
5073:
5068:
5058:
5048:
4966:
4755:
4730:
4720:
4566:
4520:
4380:
4206:
4175:
4144:
4113:
4058:
4033:
4013:
3998:
3988:
3882:
3799:
3592:
3572:
3471:
3416:
3411:
3235:
3140:
3125:
2920:
2879:
2851:
2820:
2780:
2683:
2638:
2633:
2608:
2603:
2593:
2506:
2500:
2490:
2187:
2182:
2177:
1496:. Reciprocal translocations between chromosomes 22 and 17, at sites where the
1493:
302:
199:
149:
1668:
1484:) polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds.
1042:
negative regulation of vascular associated smooth muscle cell differentiation
5133:
5103:
5098:
5093:
5088:
5083:
5063:
5053:
5043:
5033:
4725:
4685:
4581:
4556:
4315:
4310:
4305:
4295:
4290:
4285:
4275:
4196:
4134:
4068:
4048:
4043:
4038:
4023:
4018:
4008:
4003:
3897:
3872:
3637:
3557:
3476:
3421:
3311:
3250:
3240:
3145:
3032:
2830:
2825:
2815:
2723:
2713:
2698:
2673:
2668:
2658:
2653:
2648:
2288:
2144:
1131:
546:
424:
369:
356:
268:
255:
157:
1838:
1784:
1087:
positive regulation of vascular associated smooth muscle cell proliferation
1735:
1686:
1441:
1436:
5304:
5023:
4680:
4280:
4270:
4250:
4185:
4154:
4123:
4087:
3993:
3983:
3330:
2810:
2753:
2663:
2623:
2098:
1425:
1276:
1257:
5279:
4700:
4165:
3567:
2528:
2273:
2212:
1830:
1457:
1243:
1198:
1032:
positive regulation of vascular associated smooth muscle cell migration
90:
86:
82:
78:
74:
5192:
4856:
4745:
4670:
4375:
4370:
3794:
3789:
3743:
3739:
3735:
3731:
3727:
3723:
3719:
3371:
2910:
2588:
1502:
1409:
1153:
5350:
1651:
Ratner L, Josephs SF, Jarrett R, Reitz MS, Wong-Staal F (Sep 1985).
1057:
negative regulation of pri-miRNA transcription by RNA polymerase II
1052:
positive regulation of pri-miRNA transcription by RNA polymerase II
5224:
5220:
5216:
5212:
5208:
5204:
5200:
5196:
4911:
4810:
4485:
4425:
4239:
3962:
3958:
3950:
3441:
3305:
3224:
3220:
3119:
3115:
3111:
3107:
3016:
3012:
2863:
2327:
2322:
2312:
2268:
2263:
2258:
2253:
2117:
2112:
2107:
2083:
2077:
2071:
2065:
2045:
2041:
2032:
2028:
2019:
2015:
1481:
1907:
1116:
1112:
5358:
4695:
3301:
3297:
3293:
3289:
3285:
3281:
3216:
3212:
3208:
3204:
3200:
3103:
3099:
3091:
3087:
3083:
3079:
3075:
3071:
3067:
3008:
3004:
3000:
2996:
2992:
2988:
2984:
2936:
2932:
2928:
2894:
2859:
2840:
2037:
2024:
2011:
1989:
1985:
1981:
1976:
1968:
1464:
892:
negative regulation of phosphatidylinositol biosynthetic process
867:
positive regulation of reactive oxygen species metabolic process
137:
2401:
1911:
1850:
591:
1897:: CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB
1846:
982:
positive regulation of blood vessel endothelial cell migration
957:
positive regulation of phosphatidylinositol 3-kinase signaling
837:
positive regulation of glomerular mesangial cell proliferation
902:
positive regulation of phosphatidylinositol 3-kinase activity
817:
positive regulation of metanephric mesenchymal cell migration
1082:
platelet-derived growth factor receptor signaling pathway
997:
positive regulation of peptidyl-tyrosine phosphorylation
393:
5370:
1072:
positive regulation of smooth muscle cell proliferation
782:
positive regulation of protein tyrosine kinase activity
675:
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
5295:
Pituitary adenylate cyclase-activating peptide (PACAP)
822:
positive regulation of hyaluronan biosynthetic process
650:
superoxide-generating NADPH oxidase activator activity
952:
positive regulation of endothelial cell proliferation
558:
1475:
The protein encoded by this gene is a member of the
922:
positive regulation of cell population proliferation
5162:
4949:
4844:
4613:
4353:
4344:
4324:
4238:
4215:
4184:
4153:
4122:
4086:
4077:
3929:
3772:
3705:
3667:
3534:
3525:
3343:
3320:
3260:
3179:
3046:
2963:
2954:
2893:
2839:
2752:
2556:
2547:
2516:
2438:
2374:
2336:
2303:
2240:
2209:
2198:
2163:
2135:
2093:
2054:
1998:
1954:
1945:
1370:
1345:
1319:
1294:
1067:
positive regulation of smooth muscle cell migration
1027:
phosphatidylinositol phosphate biosynthetic process
967:
positive regulation of transcription, DNA-templated
877:
negative regulation of transcription, DNA-templated
5241:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
4099:Glial cell line-derived neurotrophic factor (GDNF)
3752:Cleavage products/derivatives with unknown target:
1594:
1592:
1590:
1573:
1571:
1569:
862:positive regulation of protein autophosphorylation
1540:Two splice variants have been identified for the
1102:positive regulation of protein kinase B signaling
887:metanephric glomerular mesangial cell development
340:
239:
5275:Macrophage-stimulating protein (MSP; HLP, HGFLP)
2916:Heparin-binding EGF-like growth factor (HB-EGF)
2599:Heparin-binding EGF-like growth factor (HB-EGF)
847:positive regulation of fibroblast proliferation
807:positive regulation of mitotic nuclear division
767:positive regulation of DNA biosynthetic process
640:platelet-derived growth factor receptor binding
16:Protein-coding gene in the species Homo sapiens
1599:GRCm38: Ensembl release 89: ENSMUSG00000000489
5390:
5327:Additional growth factor receptor modulators:
2413:
1923:
1862:
8:
3681:Insulin-like growth factor-2 (somatomedin A)
3563:Insulin-like growth factor-2 (somatomedin A)
3553:Insulin-like growth factor-1 (somatomedin C)
1535:dermatofibrosarcoma protuberans, sarcomatous
912:positive regulation of ERK1 and ERK2 cascade
802:positive regulation of glomerular filtration
1578:GRCh38: Ensembl release 89: ENSG00000100311
1492:Mutations in this gene are associated with
777:cellular response to growth factor stimulus
5397:
5383:
4350:
4083:
3531:
2960:
2553:
2420:
2406:
2398:
2206:
1951:
1930:
1916:
1908:
1869:
1855:
1847:
1127:
1022:negative regulation of platelet activation
812:positive regulation of MAP kinase activity
607:
381:
280:
177:
63:
1774:
1725:
1676:
1097:regulation of signaling receptor activity
1047:interleukin-18-mediated signaling pathway
962:positive regulation of calcium ion import
872:reactive oxygen species metabolic process
5285:Migration-stimulating factor (MSF; PRG4)
1454:Platelet-derived growth factor subunit B
746:collagen-containing extracellular matrix
2614:Transforming growth factor alpha (TGFα)
1884:
1565:
1523:fibroblastic and myofibroblastic tumors
762:activation of protein kinase B activity
5188:Connective tissue growth factor (CTGF)
1062:negative regulation of gene expression
1007:negative regulation of protein binding
932:positive regulation of gene expression
927:positive regulation of DNA replication
842:cellular response to mycophenolic acid
645:platelet-derived growth factor binding
18:
5251:Hepatoma-derived growth factor (HDGF)
992:positive regulation of cell migration
852:activation of protein kinase activity
345:
306:
301:
244:
203:
198:
7:
5347:
5345:
1749:Baranov E, Hornick JL (March 2020).
792:positive regulation of cell division
1012:positive regulation of MAPK cascade
630:protein heterodimerization activity
5369:. You can help Knowledge (XXG) by
1718:10.1002/j.1460-2075.1991.tb04988.x
1367:
1342:
1316:
1291:
1267:
1248:
1222:
1203:
1177:
1158:
857:multicellular organism development
563:
481:
419:
398:
14:
1460:that in humans is encoded by the
1002:extracellular matrix organization
787:peptidyl-tyrosine phosphorylation
772:positive regulation of chemotaxis
625:protein homodimerization activity
5349:
5270:Leukemia inhibitory factor (LIF)
1887:
1510:merge these two genes to form a
581:
574:
567:
329:
322:
316:
293:
228:
221:
215:
190:
27:
4438:Negative allosteric modulators:
2244:Relaxin family peptide hormones
1531:dermatofibrosarcoma protuberans
972:peptidyl-serine phosphorylation
5426:Human chromosome 22 gene stubs
4756:Gossypetin (3,5,7,8,3',4'-HHF)
3947:Platelet-derived growth factor
1554:Platelet-derived growth factor
1477:platelet-derived growth factor
937:embryonic placenta development
592:More reference expression data
547:More reference expression data
1:
4962:Placental growth factor (PGF)
314:
213:
5416:Genes on human chromosome 22
5246:Glia maturation factor (GMF)
3755:Glypromate (GPE, (1-3)IGF-1)
691:platelet alpha granule lumen
721:endoplasmic reticulum lumen
711:basolateral plasma membrane
471:right lobe of thyroid gland
455:subcutaneous adipose tissue
5442:
5344:
5178:Colony-stimulating factors
5170:Additional growth factors:
2217:Insulin-like growth factor
1767:10.1007/s12105-019-01104-3
882:protein kinase C signaling
521:sternocleidomastoid muscle
4526:SNA-120 (pegylated K252a)
3698:(against IGF-1 and IGF-2)
3660:(against IGF-1 and IGF-2)
1882:
1634:"Mouse PubMed Reference:"
1616:"Human PubMed Reference:"
1440:
1435:
1431:
1424:
1408:
1389:
1374:
1349:
1338:
1323:
1298:
1287:
1274:
1270:
1255:
1251:
1242:
1229:
1225:
1210:
1206:
1197:
1184:
1180:
1165:
1161:
1152:
1137:
1130:
1126:
1110:
660:identical protein binding
610:
606:
589:
566:
557:
544:
493:
484:
431:
422:
392:
384:
380:
363:
350:
313:
292:
283:
279:
262:
249:
212:
189:
180:
176:
131:
128:
118:
111:
106:
71:
66:
49:
44:
39:
35:
26:
21:
3362:Hepatocyte growth factor
2921:Neuregulins (heregulins)
2852:Neuregulins (heregulins)
2796:Trastuzumab duocarmazine
2509:(against angiopoietin 2)
2503:(against angiopoietin 3)
1527:giant cell fibroblastoma
1395:Chr 22: 39.22 – 39.24 Mb
635:chemoattractant activity
2709:Depatuxizumab mafodotin
2057:FGF homologous factors:
1755:Head and Neck Pathology
832:protein phosphorylation
517:vastus lateralis muscle
467:upper lobe of left lung
5332:(neurotrophin mixture)
5320:Wnt signaling proteins
5001:Allosteric modulators:
4721:Norwogonin (5,7,8-THF)
2941:5 (tomoregulin, TMEFF)
2791:Trastuzumab deruxtecan
2429:Growth factor receptor
1669:10.1093/nar/13.14.5007
917:platelet degranulation
655:growth factor activity
497:triceps brachii muscle
459:triceps brachii muscle
443:pancreatic ductal cell
347:15 E1|15 37.85 cM
5260:T-cell growth factors
3517:Telisotuzumab vedotin
2801:Trastuzumab emtansine
1488:Clinical significance
1402:Chr 15: 80 – 80.01 Mb
308:Chromosome 15 (mouse)
206:Chromosome 22 (human)
3845:EVT-901 (SAR-127963)
3578:Mecasermin rinfabate
2338:Vascular endothelial
897:response to wounding
731:extracellular matrix
701:extracellular region
67:List of PDB id codes
40:Available structures
1819:Biochem. Soc. Trans
1037:positive chemotaxis
947:monocyte chemotaxis
942:paracrine signaling
736:extracellular space
5357:This article on a
5011:Kinase inhibitors:
4874:Kinase inhibitors:
4773:Kinase inhibitors:
4448:Kinase inhibitors:
4263:Kinase inhibitors:
4223:Kinase inhibitors:
4204:Kinase inhibitors:
4173:Kinase inhibitors:
4142:Kinase inhibitors:
4111:Kinase inhibitors:
3971:Kinase inhibitors:
3585:Kinase inhibitors:
3379:Kinase inhibitors:
3168:Kinase inhibitors:
3161:Aprutumab ixadotin
2808:Kinase inhibitors:
2621:Kinase inhibitors:
2478:Kinase inhibitors:
1831:10.1042/BST0340454
1232:ENSMUSG00000000489
755:Biological process
684:Cellular component
618:Molecular function
5378:
5377:
5339:
5338:
4945:
4944:
4706:N-Acetylserotonin
4605:ReN-1820 (TrkAd5)
4234:
4233:
3768:
3767:
3713:Binding proteins:
3372:Dihexa (PNB-0408)
3339:
3338:
2950:
2949:
2864:6 (neuroglycan C)
2584:EGF (urogastrone)
2562:
2395:
2394:
2299:
2298:
2131:
2130:
1905:
1904:
1657:Nucleic Acids Res
1451:
1450:
1447:
1446:
1420:
1419:
1385:
1384:
1364:
1363:
1334:
1333:
1313:
1312:
1283:
1282:
1264:
1263:
1238:
1237:
1219:
1218:
1193:
1192:
1174:
1173:
1122:
1121:
797:heart development
602:
601:
598:
597:
553:
552:
540:
539:
478:
477:
376:
375:
275:
274:
170:PDGFB - orthologs
102:
101:
98:
97:
50:Ortholog search:
5433:
5399:
5392:
5385:
5353:
5346:
5151:Decoy receptors:
5124:Alacizumab pegol
4602:Decoy receptors:
4351:
4256:Stem cell factor
4197:Persephin (PSPN)
4135:Neurturin (NRTN)
4084:
3921:LEVI-04 (p75-Fc)
3918:Decoy receptors:
3532:
2961:
2560:
2554:
2422:
2415:
2408:
2399:
2305:Platelet-derived
2247:
2220:
2207:
2101:
2059:
2005:
1962:
1952:
1932:
1925:
1918:
1909:
1891:
1871:
1864:
1857:
1848:
1842:
1803:
1802:
1795:
1789:
1788:
1778:
1746:
1740:
1739:
1729:
1697:
1691:
1690:
1680:
1648:
1642:
1641:
1630:
1624:
1623:
1612:
1606:
1596:
1585:
1575:
1433:
1432:
1404:
1397:
1380:
1368:
1359:
1343:
1339:RefSeq (protein)
1329:
1317:
1308:
1292:
1268:
1249:
1223:
1204:
1178:
1159:
1128:
665:collagen binding
608:
594:
585:
578:
571:
564:
549:
509:digastric muscle
489:
487:Top expressed in
482:
427:
425:Top expressed in
420:
399:
382:
372:
359:
348:
333:
326:
320:
309:
297:
281:
271:
258:
247:
232:
225:
219:
208:
194:
178:
172:
123:
116:
93:
64:
58:
37:
36:
31:
19:
5441:
5440:
5436:
5435:
5434:
5432:
5431:
5430:
5406:
5405:
5404:
5403:
5342:
5340:
5335:
5280:Midkine (NEGF2)
5158:
4941:
4840:
4609:
4547:ABT-110 (PG110)
4340:
4320:
4230:
4211:
4180:
4149:
4118:
4073:
3925:
3863:ABT-110 (PG110)
3764:
3701:
3663:
3521:
3335:
3316:
3256:
3253:(against FGF23)
3175:
3042:
2946:
2889:
2835:
2748:
2559:
2543:
2512:
2434:
2426:
2396:
2391:
2370:
2332:
2295:
2241:
2236:
2210:
2201:
2194:
2159:
2137:EGF-like domain
2127:
2094:
2089:
2055:
2050:
1999:
1994:
1955:
1941:
1936:
1906:
1901:
1898:
1892:
1878:
1875:
1845:
1825:(Pt 3): 454–5.
1816:
1812:
1810:Further reading
1807:
1806:
1797:
1796:
1792:
1748:
1747:
1743:
1712:(13): 4113–20.
1699:
1698:
1694:
1663:(14): 5007–18.
1650:
1649:
1645:
1632:
1631:
1627:
1614:
1613:
1609:
1597:
1588:
1576:
1567:
1562:
1550:
1508:ring chromosome
1490:
1473:
1442:View/Edit Mouse
1437:View/Edit Human
1400:
1393:
1390:Location (UCSC)
1376:
1355:
1351:
1325:
1304:
1300:
1213:ENSG00000100311
1106:
907:cell chemotaxis
750:
679:
670:protein binding
590:
580:
579:
573:
572:
545:
536:
533:right ventricle
531:
529:temporal muscle
527:
523:
519:
515:
511:
507:
503:
499:
485:
474:
469:
465:
461:
457:
453:
449:
445:
441:
437:
423:
367:
354:
346:
336:
335:
334:
327:
307:
284:Gene location (
266:
253:
245:
235:
234:
233:
226:
204:
181:Gene location (
132:
119:
112:
73:
51:
17:
12:
11:
5:
5439:
5437:
5429:
5428:
5423:
5421:Growth factors
5418:
5408:
5407:
5402:
5401:
5394:
5387:
5379:
5376:
5375:
5354:
5337:
5336:
5334:
5333:
5323:
5322:
5317:
5310:Thrombopoietin
5307:
5302:
5297:
5292:
5287:
5282:
5277:
5272:
5267:
5253:
5248:
5243:
5238:
5231:Erythropoietin
5228:
5190:
5185:
5175:
5173:Adrenomedullin
5166:
5164:
5160:
5159:
5157:
5156:
5147:
5146:
5141:
5136:
5131:
5126:
5117:
5116:
5111:
5106:
5101:
5096:
5091:
5086:
5081:
5076:
5071:
5066:
5061:
5056:
5051:
5046:
5041:
5036:
5031:
5026:
5021:
5016:
5007:
5006:
4997:
4996:
4974:
4969:
4964:
4955:
4953:
4947:
4946:
4943:
4942:
4940:
4939:
4934:
4929:
4924:
4919:
4914:
4909:
4904:
4899:
4894:
4889:
4884:
4879:
4870:
4869:
4864:
4859:
4850:
4848:
4842:
4841:
4839:
4838:
4833:
4828:
4823:
4818:
4813:
4808:
4803:
4798:
4793:
4788:
4783:
4778:
4769:
4768:
4759:
4758:
4753:
4748:
4739:
4738:
4733:
4728:
4723:
4718:
4713:
4708:
4703:
4698:
4693:
4688:
4683:
4678:
4673:
4668:
4663:
4658:
4653:
4648:
4643:
4638:
4636:4'-DMA-7,8-DHF
4633:
4628:
4619:
4617:
4611:
4610:
4608:
4607:
4598:
4597:
4585:
4584:
4579:
4574:
4569:
4564:
4559:
4554:
4549:
4530:
4529:
4523:
4518:
4513:
4508:
4503:
4498:
4493:
4488:
4483:
4478:
4473:
4468:
4463:
4458:
4453:
4444:
4443:
4434:
4433:
4428:
4423:
4418:
4409:
4408:
4403:
4398:
4396:Gambogic amide
4393:
4388:
4383:
4378:
4373:
4368:
4359:
4357:
4348:
4342:
4341:
4339:
4338:
4330:
4328:
4322:
4321:
4319:
4318:
4313:
4308:
4303:
4298:
4293:
4288:
4283:
4278:
4273:
4268:
4259:
4258:
4253:
4244:
4242:
4236:
4235:
4232:
4231:
4229:
4228:
4219:
4217:
4213:
4212:
4210:
4209:
4200:
4199:
4190:
4188:
4182:
4181:
4179:
4178:
4169:
4168:
4166:Artemin (ARTN)
4159:
4157:
4151:
4150:
4148:
4147:
4138:
4137:
4128:
4126:
4120:
4119:
4117:
4116:
4107:
4106:
4101:
4092:
4090:
4081:
4075:
4074:
4072:
4071:
4066:
4061:
4052:
4051:
4046:
4041:
4036:
4031:
4026:
4021:
4016:
4011:
4006:
4001:
3996:
3991:
3986:
3981:
3976:
3967:
3966:
3944:
3935:
3933:
3927:
3926:
3924:
3923:
3914:
3913:
3901:
3900:
3895:
3890:
3885:
3880:
3875:
3870:
3865:
3853:
3852:
3847:
3842:
3837:
3828:
3827:
3822:
3817:
3812:
3807:
3802:
3797:
3792:
3787:
3778:
3776:
3770:
3769:
3766:
3765:
3763:
3762:
3757:
3748:
3747:
3709:
3707:
3703:
3702:
3700:
3699:
3693:
3684:
3683:
3673:
3671:
3665:
3664:
3662:
3661:
3655:
3650:
3645:
3640:
3635:
3630:
3625:
3620:
3611:
3610:
3605:
3600:
3595:
3590:
3581:
3580:
3575:
3570:
3565:
3560:
3555:
3550:
3540:
3538:
3529:
3523:
3522:
3520:
3519:
3514:
3509:
3504:
3499:
3494:
3489:
3480:
3479:
3474:
3469:
3464:
3459:
3454:
3449:
3444:
3439:
3434:
3429:
3424:
3419:
3414:
3409:
3404:
3399:
3394:
3389:
3384:
3375:
3374:
3365:
3364:
3359:
3349:
3347:
3341:
3340:
3337:
3336:
3334:
3333:
3324:
3322:
3318:
3317:
3315:
3314:
3309:
3275:
3266:
3264:
3258:
3257:
3255:
3254:
3244:
3243:
3238:
3233:
3228:
3194:
3185:
3183:
3177:
3176:
3174:
3173:
3164:
3163:
3158:
3149:
3148:
3143:
3138:
3133:
3128:
3123:
3061:
3052:
3050:
3044:
3043:
3041:
3040:
3035:
3030:
3025:
3020:
2978:
2969:
2967:
2958:
2952:
2951:
2948:
2947:
2945:
2944:
2918:
2913:
2908:
2899:
2897:
2891:
2890:
2888:
2887:
2882:
2877:
2868:
2867:
2845:
2843:
2837:
2836:
2834:
2833:
2828:
2823:
2818:
2813:
2804:
2803:
2798:
2793:
2788:
2783:
2778:
2769:
2768:
2758:
2756:
2750:
2749:
2747:
2746:
2741:
2736:
2731:
2726:
2721:
2716:
2711:
2706:
2701:
2692:
2691:
2686:
2681:
2676:
2671:
2666:
2661:
2656:
2651:
2646:
2641:
2636:
2631:
2626:
2617:
2616:
2611:
2606:
2601:
2596:
2591:
2586:
2581:
2576:
2566:
2564:
2551:
2545:
2544:
2542:
2541:
2536:
2531:
2522:
2520:
2514:
2513:
2511:
2510:
2504:
2494:
2493:
2488:
2483:
2474:
2473:
2471:Angiopoietin 3
2468:
2466:Angiopoietin 2
2459:
2458:
2456:Angiopoietin 4
2453:
2451:Angiopoietin 1
2444:
2442:
2436:
2435:
2427:
2425:
2424:
2417:
2410:
2402:
2393:
2392:
2390:
2389:
2384:
2378:
2376:
2372:
2371:
2369:
2368:
2363:
2358:
2353:
2348:
2342:
2340:
2334:
2333:
2331:
2330:
2325:
2320:
2315:
2309:
2307:
2301:
2300:
2297:
2296:
2294:
2293:
2292:
2291:
2286:
2281:
2271:
2266:
2261:
2256:
2250:
2248:
2238:
2237:
2235:
2234:
2229:
2223:
2221:
2204:
2202:Relaxin family
2196:
2195:
2193:
2192:
2191:
2190:
2185:
2180:
2169:
2167:
2161:
2160:
2158:
2157:
2152:
2147:
2141:
2139:
2133:
2132:
2129:
2128:
2126:
2125:
2120:
2115:
2110:
2104:
2102:
2091:
2090:
2088:
2087:
2081:
2075:
2069:
2062:
2060:
2052:
2051:
2049:
2048:
2035:
2022:
2008:
2006:
1996:
1995:
1993:
1992:
1979:
1965:
1963:
1949:
1943:
1942:
1939:Growth factors
1937:
1935:
1934:
1927:
1920:
1912:
1903:
1902:
1900:
1899:
1893:
1886:
1883:
1880:
1879:
1876:
1874:
1873:
1866:
1859:
1851:
1844:
1843:
1813:
1811:
1808:
1805:
1804:
1790:
1741:
1692:
1643:
1625:
1607:
1586:
1564:
1563:
1561:
1558:
1557:
1556:
1549:
1546:
1489:
1486:
1472:
1469:
1449:
1448:
1445:
1444:
1439:
1429:
1428:
1422:
1421:
1418:
1417:
1415:
1413:
1406:
1405:
1398:
1391:
1387:
1386:
1383:
1382:
1372:
1371:
1365:
1362:
1361:
1347:
1346:
1340:
1336:
1335:
1332:
1331:
1321:
1320:
1314:
1311:
1310:
1296:
1295:
1289:
1285:
1284:
1281:
1280:
1272:
1271:
1265:
1262:
1261:
1253:
1252:
1246:
1240:
1239:
1236:
1235:
1227:
1226:
1220:
1217:
1216:
1208:
1207:
1201:
1195:
1194:
1191:
1190:
1182:
1181:
1175:
1172:
1171:
1163:
1162:
1156:
1150:
1149:
1144:
1139:
1135:
1134:
1124:
1123:
1120:
1119:
1108:
1107:
1105:
1104:
1099:
1094:
1089:
1084:
1079:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
758:
756:
752:
751:
749:
748:
743:
738:
733:
728:
723:
718:
713:
708:
706:Golgi membrane
703:
698:
693:
687:
685:
681:
680:
678:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
621:
619:
615:
614:
604:
603:
600:
599:
596:
595:
587:
586:
561:
555:
554:
551:
550:
542:
541:
538:
537:
535:
534:
530:
526:
522:
518:
514:
513:left lung lobe
510:
506:
502:
498:
494:
491:
490:
479:
476:
475:
473:
472:
468:
464:
463:left ventricle
460:
456:
452:
448:
444:
440:
436:
435:olfactory bulb
432:
429:
428:
416:
415:
407:
396:
390:
389:
386:RNA expression
378:
377:
374:
373:
365:
361:
360:
352:
349:
344:
338:
337:
328:
321:
315:
311:
310:
305:
299:
298:
290:
289:
277:
276:
273:
272:
264:
260:
259:
251:
248:
243:
237:
236:
227:
220:
214:
210:
209:
202:
196:
195:
187:
186:
174:
173:
130:
126:
125:
117:
109:
108:
104:
103:
100:
99:
96:
95:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
5438:
5427:
5424:
5422:
5419:
5417:
5414:
5413:
5411:
5400:
5395:
5393:
5388:
5386:
5381:
5380:
5374:
5372:
5368:
5364:
5363:chromosome 22
5360:
5355:
5352:
5348:
5343:
5331:
5328:
5325:
5324:
5321:
5318:
5315:
5311:
5308:
5306:
5303:
5301:
5298:
5296:
5293:
5291:
5288:
5286:
5283:
5281:
5278:
5276:
5273:
5271:
5268:
5265:
5261:
5257:
5254:
5252:
5249:
5247:
5244:
5242:
5239:
5236:
5232:
5229:
5226:
5222:
5218:
5214:
5210:
5206:
5202:
5198:
5194:
5191:
5189:
5186:
5183:
5179:
5176:
5174:
5171:
5168:
5167:
5165:
5161:
5155:
5152:
5149:
5148:
5145:
5142:
5140:
5137:
5135:
5132:
5130:
5127:
5125:
5122:
5119:
5118:
5115:
5112:
5110:
5107:
5105:
5102:
5100:
5097:
5095:
5092:
5090:
5087:
5085:
5082:
5080:
5077:
5075:
5072:
5070:
5067:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5047:
5045:
5042:
5040:
5037:
5035:
5032:
5030:
5027:
5025:
5022:
5020:
5017:
5015:
5012:
5009:
5008:
5005:
5004:Cyclotraxin B
5002:
4999:
4998:
4994:
4990:
4986:
4982:
4978:
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4957:
4956:
4954:
4952:
4948:
4938:
4935:
4933:
4930:
4928:
4925:
4923:
4920:
4918:
4917:Larotrectinib
4915:
4913:
4910:
4908:
4905:
4903:
4900:
4898:
4895:
4893:
4890:
4888:
4885:
4883:
4880:
4878:
4875:
4872:
4871:
4868:
4865:
4863:
4860:
4858:
4855:
4852:
4851:
4849:
4847:
4843:
4837:
4834:
4832:
4829:
4827:
4824:
4822:
4819:
4817:
4816:Larotrectinib
4814:
4812:
4809:
4807:
4804:
4802:
4799:
4797:
4794:
4792:
4789:
4787:
4784:
4782:
4779:
4777:
4774:
4771:
4770:
4767:
4764:
4761:
4760:
4757:
4754:
4752:
4751:Cyclotraxin B
4749:
4747:
4744:
4741:
4740:
4737:
4734:
4732:
4729:
4727:
4724:
4722:
4719:
4717:
4714:
4712:
4709:
4707:
4704:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4682:
4679:
4677:
4674:
4672:
4669:
4667:
4664:
4662:
4661:Amitriptyline
4659:
4657:
4654:
4652:
4649:
4647:
4644:
4642:
4639:
4637:
4634:
4632:
4629:
4627:
4624:
4621:
4620:
4618:
4616:
4612:
4606:
4603:
4600:
4599:
4596:
4593:
4590:
4587:
4586:
4583:
4580:
4578:
4575:
4573:
4570:
4568:
4565:
4563:
4560:
4558:
4555:
4553:
4550:
4548:
4545:
4541:
4538:
4537:Against TrkA:
4535:
4532:
4531:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4492:
4491:Larotrectinib
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4446:
4445:
4442:
4439:
4436:
4435:
4432:
4429:
4427:
4424:
4422:
4421:Dexamethasone
4419:
4417:
4414:
4411:
4410:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4389:
4387:
4384:
4382:
4379:
4377:
4374:
4372:
4369:
4367:
4366:Amitriptyline
4364:
4361:
4360:
4358:
4356:
4352:
4349:
4347:
4343:
4336:
4332:
4331:
4329:
4327:
4323:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4297:
4294:
4292:
4289:
4287:
4284:
4282:
4279:
4277:
4274:
4272:
4269:
4267:
4264:
4261:
4260:
4257:
4254:
4252:
4249:
4246:
4245:
4243:
4241:
4237:
4227:
4224:
4221:
4220:
4218:
4214:
4208:
4205:
4202:
4201:
4198:
4195:
4192:
4191:
4189:
4187:
4183:
4177:
4174:
4171:
4170:
4167:
4164:
4161:
4160:
4158:
4156:
4152:
4146:
4143:
4140:
4139:
4136:
4133:
4130:
4129:
4127:
4125:
4121:
4115:
4112:
4109:
4108:
4105:
4102:
4100:
4097:
4094:
4093:
4091:
4089:
4085:
4082:
4080:
4076:
4070:
4067:
4065:
4062:
4060:
4057:
4054:
4053:
4050:
4047:
4045:
4042:
4040:
4037:
4035:
4032:
4030:
4027:
4025:
4022:
4020:
4017:
4015:
4012:
4010:
4007:
4005:
4002:
4000:
3997:
3995:
3992:
3990:
3987:
3985:
3982:
3980:
3977:
3975:
3972:
3969:
3968:
3964:
3960:
3956:
3952:
3948:
3945:
3943:
3940:
3937:
3936:
3934:
3932:
3928:
3922:
3919:
3916:
3915:
3912:
3909:
3906:
3903:
3902:
3899:
3896:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3871:
3869:
3866:
3864:
3861:
3858:
3855:
3854:
3851:
3848:
3846:
3843:
3841:
3840:Dexamethasone
3838:
3836:
3833:
3830:
3829:
3826:
3823:
3821:
3818:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3796:
3793:
3791:
3788:
3786:
3783:
3780:
3779:
3777:
3775:
3771:
3761:
3758:
3756:
3753:
3750:
3749:
3745:
3741:
3737:
3733:
3729:
3725:
3721:
3717:
3714:
3711:
3710:
3708:
3704:
3697:
3694:
3692:
3689:
3686:
3685:
3682:
3678:
3675:
3674:
3672:
3670:
3666:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3613:
3612:
3609:
3606:
3604:
3601:
3599:
3596:
3594:
3591:
3589:
3586:
3583:
3582:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3559:
3556:
3554:
3551:
3549:
3548:des(1-3)IGF-1
3545:
3542:
3541:
3539:
3537:
3533:
3530:
3528:
3524:
3518:
3515:
3513:
3512:Telisotuzumab
3510:
3508:
3505:
3503:
3500:
3498:
3495:
3493:
3490:
3488:
3485:
3482:
3481:
3478:
3475:
3473:
3470:
3468:
3465:
3463:
3460:
3458:
3455:
3453:
3450:
3448:
3445:
3443:
3440:
3438:
3435:
3433:
3430:
3428:
3425:
3423:
3420:
3418:
3415:
3413:
3410:
3408:
3405:
3403:
3400:
3398:
3395:
3393:
3390:
3388:
3385:
3383:
3380:
3377:
3376:
3373:
3370:
3369:Potentiators:
3367:
3366:
3363:
3360:
3358:
3354:
3351:
3350:
3348:
3346:
3342:
3332:
3329:
3326:
3325:
3323:
3319:
3313:
3310:
3307:
3303:
3299:
3295:
3291:
3287:
3283:
3279:
3276:
3274:
3271:
3268:
3267:
3265:
3263:
3259:
3252:
3249:
3246:
3245:
3242:
3239:
3237:
3234:
3232:
3231:Selpercatinib
3229:
3226:
3222:
3218:
3214:
3210:
3206:
3202:
3198:
3195:
3193:
3190:
3187:
3186:
3184:
3182:
3178:
3172:
3169:
3166:
3165:
3162:
3159:
3157:
3154:
3151:
3150:
3147:
3144:
3142:
3139:
3137:
3136:Selpercatinib
3134:
3132:
3129:
3127:
3124:
3121:
3117:
3113:
3109:
3105:
3101:
3097:
3093:
3089:
3085:
3081:
3077:
3073:
3069:
3065:
3062:
3060:
3057:
3054:
3053:
3051:
3049:
3045:
3039:
3036:
3034:
3031:
3029:
3028:Selpercatinib
3026:
3024:
3021:
3018:
3014:
3010:
3006:
3002:
2998:
2994:
2990:
2986:
2982:
2979:
2977:
2974:
2971:
2970:
2968:
2966:
2962:
2959:
2957:
2953:
2942:
2938:
2934:
2930:
2926:
2922:
2919:
2917:
2914:
2912:
2909:
2907:
2904:
2901:
2900:
2898:
2896:
2892:
2886:
2883:
2881:
2878:
2876:
2873:
2870:
2869:
2865:
2861:
2857:
2853:
2850:
2847:
2846:
2844:
2842:
2838:
2832:
2829:
2827:
2824:
2822:
2819:
2817:
2814:
2812:
2809:
2806:
2805:
2802:
2799:
2797:
2794:
2792:
2789:
2787:
2784:
2782:
2779:
2777:
2774:
2771:
2770:
2767:
2763:
2760:
2759:
2757:
2755:
2751:
2745:
2742:
2740:
2737:
2735:
2732:
2730:
2727:
2725:
2722:
2720:
2717:
2715:
2712:
2710:
2707:
2705:
2704:Depatuxizumab
2702:
2700:
2697:
2694:
2693:
2690:
2687:
2685:
2682:
2680:
2677:
2675:
2672:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2650:
2647:
2645:
2642:
2640:
2637:
2635:
2632:
2630:
2627:
2625:
2622:
2619:
2618:
2615:
2612:
2610:
2607:
2605:
2602:
2600:
2597:
2595:
2592:
2590:
2587:
2585:
2582:
2580:
2577:
2575:
2571:
2568:
2567:
2565:
2563:
2555:
2552:
2550:
2546:
2540:
2537:
2535:
2532:
2530:
2527:
2524:
2523:
2521:
2519:
2515:
2508:
2505:
2502:
2499:
2496:
2495:
2492:
2489:
2487:
2484:
2482:
2479:
2476:
2475:
2472:
2469:
2467:
2464:
2461:
2460:
2457:
2454:
2452:
2449:
2446:
2445:
2443:
2441:
2437:
2433:
2430:
2423:
2418:
2416:
2411:
2409:
2404:
2403:
2400:
2388:
2385:
2383:
2380:
2379:
2377:
2373:
2367:
2364:
2362:
2359:
2357:
2354:
2352:
2349:
2347:
2344:
2343:
2341:
2339:
2335:
2329:
2326:
2324:
2321:
2319:
2316:
2314:
2311:
2310:
2308:
2306:
2302:
2290:
2287:
2285:
2282:
2280:
2277:
2276:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2252:
2251:
2249:
2246:
2245:
2239:
2233:
2230:
2228:
2225:
2224:
2222:
2219:
2218:
2214:
2208:
2205:
2203:
2197:
2189:
2186:
2184:
2181:
2179:
2176:
2175:
2174:
2171:
2170:
2168:
2166:
2162:
2156:
2153:
2151:
2148:
2146:
2143:
2142:
2140:
2138:
2134:
2124:
2121:
2119:
2116:
2114:
2111:
2109:
2106:
2105:
2103:
2100:
2097:
2096:hormone-like:
2092:
2085:
2082:
2079:
2076:
2073:
2070:
2067:
2064:
2063:
2061:
2058:
2053:
2047:
2043:
2039:
2036:
2034:
2030:
2026:
2023:
2021:
2017:
2013:
2010:
2009:
2007:
2004:
2003:
1997:
1991:
1987:
1983:
1980:
1978:
1974:
1970:
1967:
1966:
1964:
1961:
1959:
1953:
1950:
1948:
1944:
1940:
1933:
1928:
1926:
1921:
1919:
1914:
1913:
1910:
1896:
1890:
1885:
1881:
1872:
1867:
1865:
1860:
1858:
1853:
1852:
1849:
1840:
1836:
1832:
1828:
1824:
1820:
1815:
1814:
1809:
1800:
1794:
1791:
1786:
1782:
1777:
1772:
1768:
1764:
1760:
1756:
1752:
1745:
1742:
1737:
1733:
1728:
1723:
1719:
1715:
1711:
1707:
1703:
1696:
1693:
1688:
1684:
1679:
1674:
1670:
1666:
1662:
1658:
1654:
1647:
1644:
1639:
1635:
1629:
1626:
1621:
1617:
1611:
1608:
1604:
1600:
1595:
1593:
1591:
1587:
1583:
1579:
1574:
1572:
1570:
1566:
1559:
1555:
1552:
1551:
1547:
1545:
1543:
1538:
1536:
1532:
1528:
1525:of the skin:
1524:
1520:
1517:
1513:
1509:
1505:
1504:
1499:
1495:
1487:
1485:
1483:
1478:
1470:
1468:
1466:
1463:
1459:
1455:
1443:
1438:
1434:
1430:
1427:
1423:
1416:
1414:
1411:
1407:
1403:
1399:
1396:
1392:
1388:
1381:
1379:
1373:
1369:
1366:
1360:
1358:
1354:
1348:
1344:
1341:
1337:
1330:
1328:
1322:
1318:
1315:
1309:
1307:
1303:
1297:
1293:
1290:
1288:RefSeq (mRNA)
1286:
1279:
1278:
1273:
1269:
1266:
1260:
1259:
1254:
1250:
1247:
1245:
1241:
1234:
1233:
1228:
1224:
1221:
1215:
1214:
1209:
1205:
1202:
1200:
1196:
1189:
1188:
1183:
1179:
1176:
1170:
1169:
1164:
1160:
1157:
1155:
1151:
1148:
1145:
1143:
1140:
1136:
1133:
1129:
1125:
1118:
1114:
1109:
1103:
1100:
1098:
1095:
1093:
1090:
1088:
1085:
1083:
1080:
1078:
1075:
1073:
1070:
1068:
1065:
1063:
1060:
1058:
1055:
1053:
1050:
1048:
1045:
1043:
1040:
1038:
1035:
1033:
1030:
1028:
1025:
1023:
1020:
1018:
1015:
1013:
1010:
1008:
1005:
1003:
1000:
998:
995:
993:
990:
988:
985:
983:
980:
978:
975:
973:
970:
968:
965:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
923:
920:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
759:
757:
754:
753:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
688:
686:
683:
682:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
622:
620:
617:
616:
613:
612:Gene ontology
609:
605:
593:
588:
584:
577:
570:
565:
562:
560:
556:
548:
543:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
495:
492:
488:
483:
480:
470:
466:
462:
458:
454:
450:
446:
442:
439:apex of heart
438:
434:
433:
430:
426:
421:
418:
417:
414:
412:
408:
406:
405:
401:
400:
397:
395:
391:
387:
383:
379:
371:
366:
362:
358:
353:
343:
339:
332:
325:
319:
312:
304:
300:
296:
291:
287:
282:
278:
270:
265:
261:
257:
252:
242:
238:
231:
224:
218:
211:
207:
201:
197:
193:
188:
184:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
127:
122:
115:
110:
105:
94:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
5371:expanding it
5356:
5341:
5330:Cerebrolysin
5326:
5300:Pleiotrophin
5256:Interleukins
5169:
5150:
5120:
5039:Fruquintinib
5029:Cabozantinib
5010:
5000:
4958:
4922:Lestaurtinib
4873:
4853:
4821:Lestaurtinib
4772:
4762:
4743:Antagonists:
4742:
4676:Deoxygedunin
4631:3,7,8,2'-THF
4622:
4601:
4592:Against NGF:
4591:
4588:
4544:Against NGF:
4543:
4536:
4533:
4496:Lestaurtinib
4447:
4437:
4431:Testosterone
4413:Antagonists:
4412:
4362:
4262:
4247:
4222:
4203:
4193:
4172:
4162:
4141:
4131:
4110:
4095:
4055:
3970:
3954:
3938:
3917:
3908:Against NGF:
3907:
3904:
3860:Against NGF:
3859:
3856:
3850:Testosterone
3832:Antagonists:
3831:
3781:
3751:
3712:
3687:
3676:
3653:Teprotumumab
3614:
3584:
3543:
3492:Ficlatuzumab
3487:Emibetuzumab
3483:
3437:JNJ-38877605
3407:Cabozantinib
3378:
3368:
3357:Fosgonimeton
3352:
3327:
3269:
3247:
3188:
3171:Infigratinib
3167:
3152:
3055:
2972:
2906:Betacellulin
2902:
2885:Seribantumab
2871:
2848:
2807:
2772:
2766:Unknown/none
2765:
2761:
2695:
2620:
2579:Betacellulin
2574:Amphiregulin
2569:
2561:(ErbB1/HER1)
2525:
2497:
2477:
2463:Antagonists:
2462:
2447:
2440:Angiopoietin
2317:
2242:
2211:
2200:Insulin/IGF/
2165:TGFβ pathway
2095:
2056:
2000:
1958:FGF receptor
1956:
1894:
1822:
1818:
1793:
1761:(1): 43–58.
1758:
1754:
1744:
1709:
1705:
1695:
1660:
1656:
1646:
1637:
1628:
1619:
1610:
1541:
1539:
1515:
1511:
1501:
1497:
1491:
1474:
1461:
1453:
1452:
1375:
1350:
1324:
1299:
1275:
1256:
1230:
1211:
1185:
1166:
1146:
1141:
827:MAPK cascade
716:cell surface
409:
402:
129:External IDs
72:
5290:Oncomodulin
5154:Aflibercept
5144:Ranibizumab
5139:Ramucirumab
5129:Bevacizumab
5121:Antibodies:
5079:Regorafenib
5019:Altiratinib
4932:ONO-5390556
4902:Entrectinib
4877:Altiratinib
4831:ONO-5390556
4801:Entrectinib
4776:Altiratinib
4562:Frunevetmab
4534:Antibodies:
4511:ONO-5390556
4476:Entrectinib
4451:Altiratinib
4406:Tavilermide
4301:Quizartinib
4240:SCF (c-Kit)
4064:Ramucirumab
4056:Antibodies:
4029:Quizartinib
3979:Avapritinib
3942:Becaplermin
3878:Frunevetmab
3857:Antibodies:
3760:Trofinetide
3691:Dusigitumab
3688:Antibodies:
3643:Robatumumab
3633:Figitumumab
3628:Dalotuzumab
3623:Cixutumumab
3615:Antibodies:
3507:Rilotumumab
3502:Onartuzumab
3497:Flanvotumab
3484:Antibodies:
3452:PF-04217903
3382:Altiratinib
3345:HGF (c-Met)
3248:Antibodies:
3153:Antibodies:
2875:Duligotumab
2872:Antibodies:
2786:Trastuzumab
2776:Ertumaxomab
2773:Antibodies:
2744:Zalutumumab
2739:Panitumumab
2734:Nimotuzumab
2729:Necitumumab
2719:Imgatuzumab
2696:Antibodies:
2679:Osimertinib
2644:Dacomitinib
2539:Dapiclermin
2498:Antibodies:
2481:Altiratinib
1877:PDB gallery
1519:fusion gene
987:hemopoiesis
741:Golgi lumen
368:80,014,977
355:79,995,874
267:39,244,982
254:39,223,359
107:Identifiers
5410:Categories
5109:Vandetanib
5074:Rebastinib
5069:Pegaptanib
5059:Nintedanib
5049:Lenvatinib
5014:Agerafenib
4967:Ripretinib
4892:CH-7057288
4791:CH-7057288
4656:7,8,3'-THF
4651:7,8,2'-THF
4577:Ranevetmab
4567:Fulranumab
4521:Rebastinib
4466:CH-7057288
4381:Cenegermin
4266:Agerafenib
4226:Agerafenib
4207:Vandetanib
4176:Vandetanib
4145:Vandetanib
4114:Vandetanib
4059:Olaratumab
4034:Ripretinib
4014:Nintedanib
3999:Lenvatinib
3989:Crenolanib
3974:Agerafenib
3893:Ranevetmab
3883:Fulranumab
3800:Cenegermin
3774:LNGF (p75)
3696:Xentuzumab
3658:Xentuzumab
3603:NVP-AEW541
3598:NVP-ADW742
3593:Linsitinib
3588:BMS-754807
3573:Mecasermin
3472:Tivantinib
3462:PHA-665752
3457:PF-2341066
3427:Golvatinib
3417:Crizotinib
3412:Capmatinib
3402:BMS-777607
3397:Amuvatinib
3273:Ersofermin
3236:Sprifermin
3192:Ersofermin
3141:Sprifermin
3131:Repifermin
3126:Palifermin
3059:Ersofermin
3038:Velafermin
3023:Repifermin
2976:Ersofermin
2895:ErbB4/HER4
2880:Patritumab
2841:ErbB3/HER3
2821:Mubritinib
2781:Pertuzumab
2754:ErbB2/HER2
2684:Vandetanib
2639:Canertinib
2634:Brigatinib
2629:Agerafenib
2609:Nepidermin
2604:Murodermin
2594:Epiregulin
2549:EGF (ErbB)
2507:Nesvacumab
2501:Evinacumab
2491:Rebastinib
2432:modulators
2387:Hepatocyte
1947:Fibroblast
1605:, May 2017
1584:, May 2017
1560:References
1494:meningioma
505:right lung
447:right lung
413:(ortholog)
150:HomoloGene
5361:on human
5134:Icrucumab
5114:WHI-P 154
5104:Tivozanib
5099:Toceranib
5094:Sunitinib
5089:Sorafenib
5084:Semaxanib
5064:Pazopanib
5054:Motesanib
5044:Lapatinib
5034:Cediranib
4972:Telbermin
4959:Agonists:
4907:GZ-389988
4887:CE-245677
4854:Agonists:
4806:GZ-389988
4786:CE-245677
4686:Diosmetin
4623:Agonists:
4589:Aptamers:
4582:Tanezumab
4557:Fasinumab
4501:Milciclib
4481:GZ-389988
4461:CE-245677
4363:Agonists:
4316:Toceranib
4311:Sunitinib
4306:Sorafenib
4296:Pazopanib
4291:Nilotinib
4286:Masitinib
4276:Dasatinib
4248:Agonists:
4194:Agonists:
4163:Agonists:
4132:Agonists:
4104:Liatermin
4096:Agonists:
4079:RET (GFL)
4069:Tovetumab
4049:Toceranib
4044:Sorafenib
4039:Sunitinib
4024:Radotinib
4019:Pazopanib
4009:Motesanib
4004:Masitinib
3939:Agonists:
3905:Aptamers:
3898:Tanezumab
3873:Fasinumab
3782:Agonists:
3638:Ganitumab
3558:IGF-1 LR3
3477:Volitinib
3432:INCB28060
3422:Foretinib
3328:Agonists:
3312:Trafermin
3270:Agonists:
3251:Burosumab
3241:Trafermin
3189:Agonists:
3156:Aprutumab
3146:Trafermin
3108:10 (KGF2)
3056:Agonists:
3033:Trafermin
3013:10 (KGF2)
2973:Agonists:
2903:Agonists:
2849:Agonists:
2831:Tucatinib
2826:Neratinib
2816:Lapatinib
2724:Matuzumab
2714:Futuximab
2699:Cetuximab
2689:WHI-P 154
2674:Neratinib
2669:Lapatinib
2659:Grandinin
2654:Gefitinib
2649:Erlotinib
2526:Agonists:
2486:CE-245677
2448:Agonists:
1378:NP_035187
1357:NP_148937
1353:NP_002599
1327:NM_011057
1306:NM_002608
1302:NM_033016
1132:Orthologs
696:cytoplasm
501:left lung
451:vena cava
158:GeneCards
5316:instead)
5305:Renalase
5266:instead)
5237:instead)
5184:instead)
5024:Axitinib
4993:D (FIGF)
4937:PLX-7486
4927:ONO-4474
4882:AZD-6918
4836:PLX-7486
4826:ONO-4474
4781:AZD-6918
4763:Ligands:
4681:Deprenyl
4641:7,3'-DHF
4572:MEDI-578
4552:ASP-6294
4516:PLX-7486
4506:ONO-4474
4456:AZD-6918
4416:ALE-0540
4337:instead.
4281:Imatinib
4271:Axitinib
4251:Ancestim
4216:Unsorted
3994:Imatinib
3984:Axitinib
3888:MEDI-578
3868:ASP-6294
3835:ALE-0540
3677:Agonists
3618:AVE-1642
3544:Agonists
3467:SU-11274
3353:Agonists
3331:FGF15/19
3321:Unsorted
3286:2 (bFGF)
3205:2 (bFGF)
3072:2 (bFGF)
2989:2 (bFGF)
2811:Afatinib
2762:Agonists
2664:Icotinib
2624:Afatinib
2570:Agonists
2099:FGF15/19
1960:ligands:
1839:16709185
1785:31950474
1601:–
1580:–
1548:See also
1471:Function
1426:Wikidata
1111:Sources:
726:membrane
5193:Ephrins
4897:DS-6051
4796:DS-6051
4701:LM22A-4
4691:DMAQ-B1
4646:7,8-DHF
4626:3,7-DHF
4595:RBM-004
4540:GBR-900
4471:DS-6051
4441:VM-902A
3911:RBM-004
3608:OSl-906
3568:Insulin
3447:MK-2461
3392:AMG-458
2529:Axokine
2274:Relaxin
2213:Insulin
1776:7021862
1736:1661670
1687:2991848
1603:Ensembl
1582:Ensembl
1458:protein
1244:UniProt
1199:Ensembl
1138:Species
1117:QuickGO
388:pattern
246:22q13.1
114:Aliases
5163:Others
4857:BNN-20
4746:ANA-12
4671:BNN-20
4391:DHEA-S
4376:BNN-27
4371:BNN-20
3810:DHEA-S
3795:BNN-27
3790:BNN-20
3706:Others
2911:Epigen
2589:Epigen
2361:VEGF-D
2356:VEGF-C
2351:VEGF-B
2346:VEGF-A
2155:HB-EGF
2086:(FHF4)
2080:(FHF2)
2074:(FHF1)
2068:(FHF3)
1837:
1783:
1773:
1734:
1727:453161
1724:
1706:EMBO J
1685:
1678:321845
1675:
1544:gene.
1533:, and
1503:COL1A1
1412:search
1410:PubMed
1277:P31240
1258:P01127
1154:Entrez
559:BioGPS
138:190040
5365:is a
5312:(see
5262:(see
5233:(see
5180:(see
4912:K252a
4811:K252a
4486:K252a
4426:FX007
4186:GFRα4
4155:GFRα3
4124:GFRα2
4088:GFRα1
3716:IGFBP
3669:IGF-2
3648:R1507
3536:IGF-1
3442:K252a
3262:FGFR4
3181:FGFR3
3048:FGFR2
2965:FGFR1
2382:Nerve
2375:Other
2328:PDGFD
2323:PDGFC
2318:PDGFB
2313:PDGFA
2269:INSL6
2264:INSL5
2259:INSL4
2254:INSL3
2188:TGFβ3
2183:TGFβ2
2178:TGFβ1
2123:FGF23
2118:FGF21
2113:FGF19
2108:FGF15
2084:FGF14
2078:FGF13
2072:FGF12
2066:FGF11
2046:FGF20
2042:FGF16
2033:FGF18
2029:FGF17
2020:FGF22
2016:FGF10
1542:PDGFB
1516:PDGFB
1512:COL1A
1498:PDGFB
1482:PDGFA
1462:PDGFB
1456:is a
1187:18591
1147:Mouse
1142:Human
1113:Amigo
525:ankle
411:Mouse
404:Human
351:Start
286:Mouse
250:Start
183:Human
162:PDGFB
154:74303
146:97528
121:PDGFB
22:PDGFB
5367:stub
5359:gene
5314:here
5264:here
5235:here
5182:here
4977:VEGF
4951:VEGF
4867:NT-3
4862:DHEA
4846:TrkC
4766:DHEA
4736:TDP6
4716:NT-4
4711:NT-3
4696:HIOC
4666:BDNF
4615:TrkB
4386:DHEA
4355:TrkA
4335:here
4333:See
4326:TGFβ
3931:PDGF
3825:NT-4
3820:NT-3
3805:DHEA
3785:BDNF
2534:CNTF
2518:CNTF
2232:IGF2
2227:IGF1
2215:and
2173:TGFβ
2145:TGFα
2038:FGF9
2025:FGF8
2012:FGF7
1990:FGF6
1986:FGF4
1982:FGF3
1977:FGF5
1973:FGF2
1969:FGF1
1895:1pdg
1835:PMID
1781:PMID
1732:PMID
1683:PMID
1500:and
1465:gene
1168:5155
394:Bgee
342:Band
303:Chr.
241:Band
200:Chr.
134:OMIM
91:4QCI
87:4HQX
83:4HQU
79:3MJG
75:1PDG
56:RCSB
53:PDBe
4731:R13
4401:NGF
4346:Trk
3815:NGF
3527:IGF
3387:AM7
3278:FGF
3197:FGF
3098:),
3096:KGF
3064:FGF
2981:FGF
2956:FGF
2558:EGF
2366:PGF
2150:EGF
2002:KGF
1827:doi
1771:PMC
1763:doi
1722:PMC
1714:doi
1673:PMC
1665:doi
1537:.
364:End
263:End
166:OMA
142:MGI
46:PDB
5412::
5225:B3
5223:,
5221:B2
5219:,
5217:B1
5215:,
5213:A5
5211:,
5209:A4
5207:,
5205:A3
5203:,
5201:A2
5199:,
5197:A1
4991:,
4987:,
4983:,
4726:R7
4542:;
3961:,
3957:,
3953:,
3742:,
3738:,
3734:,
3730:,
3726:,
3722:,
3679::
3546::
3355::
3306:19
3304:,
3300:,
3296:,
3292:,
3288:,
3284:,
3225:23
3223:,
3221:18
3219:,
3215:,
3211:,
3207:,
3203:,
3120:22
3118:,
3116:18
3114:,
3112:17
3110:,
3106:,
3102:,
3090:,
3086:,
3082:,
3078:,
3074:,
3070:,
3017:20
3015:,
3011:,
3007:,
3003:,
2999:,
2995:,
2991:,
2987:,
2939:,
2935:,
2931:,
2927:,
2862:,
2858:,
2764::
2572::
1833:.
1823:34
1821:.
1779:.
1769:.
1759:14
1757:.
1753:.
1730:.
1720:.
1710:10
1708:.
1704:.
1681:.
1671:.
1661:13
1659:.
1655:.
1636:.
1618:.
1589:^
1568:^
1529:,
1467:.
1115:/
370:bp
357:bp
269:bp
256:bp
164:;
160::
156:;
152::
148:;
144::
140:;
136::
89:,
85:,
81:,
77:,
5398:e
5391:t
5384:v
5373:.
5258:/
5227:)
5195:(
4995:)
4989:C
4985:B
4981:A
4979:(
4528:)
3965:)
3963:D
3959:C
3955:B
3951:A
3949:(
3746:)
3744:7
3740:6
3736:5
3732:4
3728:3
3724:2
3720:1
3718:(
3308:)
3302:9
3298:8
3294:6
3290:4
3282:1
3280:(
3227:)
3217:9
3213:8
3209:4
3201:1
3199:(
3122:)
3104:9
3100:8
3094:(
3092:7
3088:6
3084:5
3080:4
3076:3
3068:1
3066:(
3019:)
3009:8
3005:6
3001:5
2997:4
2993:3
2985:1
2983:(
2943:)
2937:4
2933:3
2929:2
2925:1
2923:(
2866:)
2860:2
2856:1
2854:(
2421:e
2414:t
2407:v
2289:3
2284:2
2279:1
2044:/
2040:/
2031:/
2027:/
2018:/
2014:/
1988:/
1984:/
1975:/
1971:/
1931:e
1924:t
1917:v
1870:e
1863:t
1856:v
1841:.
1829::
1801:.
1787:.
1765::
1738:.
1716::
1689:.
1667::
1640:.
1622:.
1514:-
1480:(
288:)
185:)
168::
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