310:
287:
184:
209:
575:
568:
2270:
561:
316:
215:
29:
1168:, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Recently, it has been shown through the use of PDE4A knock out mice that PDE4A may play a role in the regulation of anxiety and emotional memory.
1465:
Wallace DA, Johnston LA, Huston E, MacMaster D, Houslay TM, Cheung YF, Campbell L, Millen JE, Smith RA, Gall I, Knowles RG, Sullivan M, Houslay MD (Jun 2005). "Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase
55:
1717:
Sullivan M, Egerton M, Shakur Y, Marquardsen A, Houslay MD (Sep 1994). "Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)".
1792:"The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram"
2146:"TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid"
1881:"Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition"
1838:"Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2"
1673:"Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19 [corrected]"
2044:
Lario PI, Bobechko B, Bateman K, Kelly J, Vrielink A, Huang Z (Oct 2001). "Purification and characterization of the human PDE4A catalytic domain (PDE4A330-723) expressed in Sf9 cells".
2000:"HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway"
1509:
Mackenzie KF, Topping EC, Bugaj-Gaweda B, Deng C, Cheung YF, Olsen AE, Stockard CR, High
Mitchell L, Baillie GS, Grizzle WE, De Vivo M, Houslay MD, Wang D, Bolger GB (Apr 2008).
2144:
Baillie GS, Huston E, Scotland G, Hodgkin M, Gall I, Peden AH, MacKenzie C, Houslay ES, Currie R, Pettitt TR, Walmsley AR, Wakelam MJ, Warwicker J, Houslay MD (Aug 2002).
1749:"A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs"
323:
222:
2269:
1305:
Milatovich A, Bolger G, Michaeli T, Francke U (Mar 1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse".
3129:
823:
804:
145:
2503:
1425:"Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10"
2750:
3149:
2249:
1287:
1269:
2664:
2190:
Pryzwansky KB, Madden VJ (Jun 2003). "Type 4A cAMP-specific phosphodiesterase is stored in granules of human neutrophils and eosinophils".
2765:
2759:
2560:
2310:
1153:
309:
2608:
1071:
2719:
2508:
1078:
286:
1351:
2826:
2714:
1256:
1235:
1955:"Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication"
2635:
2545:
2498:
1165:
208:
183:
1252:
52:
3057:
2998:
2075:"Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia"
1511:"Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change"
1231:
3102:
2669:
2659:
125:
3062:
2954:
2579:
1200:
322:
221:
2648:
2644:
2640:
2556:
2389:
315:
214:
2910:
2856:
2816:
2775:
2679:
2518:
2486:
2372:
2336:
2242:
1380:
Hansen RT, Conti M, Zhang H-T (2014). "Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior".
2564:
2413:
2327:
868:
133:
1628:
Livi GP, Kmetz P, McHale MM, Cieslinski LB, Sathe GM, Taylor DP, Davis RL, Torphy TJ, Balcarek JM (Jun 1990).
2433:
2303:
1747:
Bolger G, Michaeli T, Martins T, St John T, Steiner B, Rodgers L, Riggs M, Wigler M, Ferguson K (Oct 1993).
849:
1562:
Houslay MD, Schafer P, Zhang KY (Nov 2005). "Keynote review: phosphodiesterase-4 as a therapeutic target".
2989:
2628:
1591:
Zhang KY, Ibrahim PN, Gillette S, Bollag G (Dec 2005). "Phosphodiesterase-4 as a potential drug target".
2924:
2821:
2613:
2574:
2438:
2360:
1423:
Rena G, Begg F, Ross A, MacKenzie C, McPhee I, Campbell L, Huston E, Sullivan M, Houslay MD (May 2001).
197:
3107:
2942:
2937:
2870:
2530:
2355:
2235:
1630:"Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase"
112:
2962:
2932:
2736:
2731:
2655:
2591:
2377:
1208:
1204:
1046:
1021:
1017:
1013:
1009:
983:
950:
946:
942:
938:
1879:
McPhee I, Yarwood SJ, Scotland G, Huston E, Beard MB, Ross AH, Houslay ES, Houslay MD (Apr 1999).
3095:
2947:
2428:
2418:
2296:
2215:
2178:
2132:
2074:
2032:
1913:
1824:
1790:
Huston E, Pooley L, Julien P, Scotland G, McPhee I, Sullivan M, Bolger G, Houslay MD (Dec 1996).
1616:
1491:
1405:
1330:
157:
2101:
Laliberté F, Liu S, Gorseth E, Bobechko B, Bartlett A, Lario P, Gresser MJ, Huang Z (Feb 2002).
1054:
1050:
1025:
979:
975:
954:
2896:
2841:
2809:
2684:
2403:
2207:
2170:
2124:
2089:
2061:
2024:
1986:
1941:
1905:
1867:
1816:
1778:
1735:
1705:
1659:
1608:
1579:
1540:
1483:
1447:
1424:
1397:
1322:
574:
567:
105:
45:
2972:
2552:
2457:
2452:
2408:
2199:
2160:
2114:
2053:
2014:
1976:
1966:
1895:
1857:
1849:
1806:
1768:
1760:
1727:
1695:
1687:
1649:
1641:
1600:
1571:
1530:
1522:
1475:
1439:
1389:
1314:
402:
333:
277:
232:
560:
153:
3074:
2888:
2804:
2799:
2794:
2707:
2702:
2462:
2340:
377:
1998:
Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S (Feb 2001).
1953:
Secchiero P, Zella D, Curreli S, Mirandola P, Capitani S, Gallo RC, Zauli G (Dec 2000).
3047:
3042:
3037:
2423:
2398:
2394:
2367:
2350:
1862:
1837:
1700:
1535:
1510:
28:
2119:
2102:
1773:
1748:
1654:
1629:
1575:
738:
733:
728:
723:
718:
713:
697:
692:
687:
682:
677:
672:
667:
662:
646:
641:
636:
631:
626:
621:
616:
3143:
3133:
2788:
2697:
2447:
1981:
1954:
1731:
603:
2182:
2136:
2036:
1917:
1828:
1620:
1409:
1334:
2915:
2846:
2569:
2490:
2219:
2145:
1880:
1791:
1495:
395:
174:
1999:
1927:"Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells"
1672:
1199:(anxiolytic with alleged antiinflammatory properties) – inhibits PDE4A isoform 1,
137:
1926:
161:
3090:
2861:
2755:
2618:
2584:
2522:
2288:
1292:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1274:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1190:
1959:
Proceedings of the
National Academy of Sciences of the United States of America
478:
3067:
2203:
1604:
1393:
1184:
1161:
294:
191:
141:
1900:
1811:
2980:
2779:
2692:
2319:
2278:: N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE, NMR, 7 STRUCTURES
1196:
768:
538:
416:
361:
348:
260:
247:
149:
2211:
2174:
2165:
2128:
2093:
2065:
2057:
2028:
1990:
1971:
1945:
1909:
1764:
1612:
1583:
1544:
1487:
1479:
1451:
1401:
2019:
1871:
1820:
1782:
1739:
1709:
1663:
1645:
1326:
1118:
1113:
3025:
3020:
3015:
2836:
2471:
2323:
1443:
1180:
1102:
913:
894:
3032:
3010:
3005:
2623:
1836:
Sullivan M, Rena G, Begg F, Gordon L, Olsen AS, Houslay MD (Aug 1998).
1526:
1318:
880:
835:
1853:
1691:
82:
78:
74:
3052:
2985:
2878:
2476:
2384:
1134:
1086:
790:
2994:
2745:
2073:
Moon E, Lee R, Near R, Weintraub L, Wolda S, Lerner A (Feb 2002).
753:
749:
2726:
2603:
2596:
2540:
2535:
1157:
1141:
129:
2292:
2231:
2103:"In vitro PKA phosphorylation-mediated human PDE4A4 activation"
583:
2227:
1176:
PDE4A inhibition is a target of a number of drugs including:
1187:(antiinflammatory) – inhibits PDE4A isoforms 1, 2, 6, and 7
1193:(antiinflammatory) – inhibits PDE4A isoforms 1, 2, and 6
385:
550:
3083:
2971:
2923:
2909:
2887:
2869:
2855:
2835:
2774:
2678:
2517:
2485:
2335:
1039:
1002:
968:
931:
497:
dentate gyrus of hippocampal formation granule cell
1248:
1246:
1244:
1227:
1225:
1223:
637:3',5'-cyclic-nucleotide phosphodiesterase activity
2614:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
332:
231:
1934:Investigative Ophthalmology & Visual Science
1152:The protein encoded by this gene belongs to the
1131:cAMP-specific 3',5'-cyclic phosphodiesterase 4A
16:Protein-coding gene in the species Homo sapiens
1671:Horton YM, Sullivan M, Houslay MD (Jun 1995).
1253:GRCm38: Ensembl release 89: ENSMUSG00000032177
2304:
2243:
1352:"PDE4A phosphodiesterase 4A, cAMP-specific (
8:
739:G protein-coupled receptor signaling pathway
1925:Zhou L, Thompson WJ, Potter DE (Jul 1999).
1232:GRCh38: Ensembl release 89: ENSG00000065989
647:3',5'-cyclic-AMP phosphodiesterase activity
3130:United States National Library of Medicine
2920:
2866:
2852:
2311:
2297:
2289:
2250:
2236:
2228:
1183:(antidepressant and antiinflammatory) and
764:
599:
373:
272:
169:
116:, DPDE2, PDE4, PDE46, phosphodiesterase 4A
63:
2164:
2118:
2018:
1980:
1970:
1899:
1861:
1810:
1772:
1699:
1653:
1534:
3128:This article incorporates text from the
1346:
1344:
729:regulation of protein kinase A signaling
2504:Ubiquitin carboxy-terminal hydrolase L1
2265:
2046:Archives of Biochemistry and Biophysics
1219:
18:
3084:either deoxy- or ribo-
1593:Expert Opinion on Therapeutic Targets
719:regulation of cAMP-mediated signaling
617:phosphoric diester hydrolase activity
337:
298:
293:
236:
195:
190:
7:
2665:Protein serine/threonine phosphatase
2766:Cyclic nucleotide phosphodiesterase
2760:Clostridium perfringens alpha toxin
2561:Tartrate-resistant acid phosphatase
2153:The Journal of Biological Chemistry
1888:The Journal of Biological Chemistry
1799:The Journal of Biological Chemistry
1307:Somatic Cell and Molecular Genetics
1154:cyclic nucleotide phosphodiesterase
2609:Pyruvate dehydrogenase phosphatase
1036:
999:
965:
928:
904:
885:
859:
840:
814:
795:
555:
473:
411:
390:
14:
2509:4-hydroxybenzoyl-CoA thioesterase
1137:that in humans is encoded by the
431:lateral nuclear group of thalamus
2268:
573:
566:
559:
525:lumbar subsegment of spinal cord
321:
314:
308:
285:
220:
213:
207:
182:
27:
2827:N-acetylglucosamine-6-sulfatase
2715:Sphingomyelin phosphodiesterase
673:perinuclear region of cytoplasm
2636:Inositol-phosphate phosphatase
2499:Palmitoyl protein thioesterase
1753:Molecular and Cellular Biology
1634:Molecular and Cellular Biology
584:More reference expression data
539:More reference expression data
1:
2999:RNA-induced silencing complex
2120:10.1016/S0014-5793(02)02259-7
1576:10.1016/S1359-6446(05)03622-6
306:
205:
3150:Genes on human chromosome 19
3103:Serratia marcescens nuclease
2670:Dual-specificity phosphatase
2660:Protein tyrosine phosphatase
1732:10.1016/0898-6568(94)00039-5
2580:Fructose 1,6-bisphosphatase
714:sensory perception of smell
3166:
2817:Galactosamine-6 sulfatase
2373:6-phosphogluconolactonase
2263:
2204:10.1007/s00441-003-0728-y
1605:10.1517/14728222.9.6.1283
1394:10.1007/s00213-014-3480-y
1288:"Mouse PubMed Reference:"
1270:"Human PubMed Reference:"
1164:the secondary messenger,
1117:
1112:
1108:
1101:
1085:
1066:
1043:
1006:
995:
972:
935:
924:
911:
907:
892:
888:
879:
866:
862:
847:
843:
834:
821:
817:
802:
798:
789:
774:
767:
763:
747:
602:
598:
581:
558:
549:
536:
485:
476:
463:anterior cingulate cortex
423:
414:
384:
376:
372:
355:
342:
305:
284:
275:
271:
254:
241:
204:
181:
172:
168:
123:
120:
110:
103:
98:
71:
66:
49:
44:
39:
35:
26:
21:
2565:Purple acid phosphatases
2192:Cell and Tissue Research
2082:Clinical Cancer Research
1901:10.1074/jbc.274.17.11796
1812:10.1074/jbc.271.49.31334
1072:Chr 19: 10.42 – 10.47 Mb
1842:The Biochemical Journal
1680:The Biochemical Journal
1515:The Biochemical Journal
1079:Chr 9: 21.08 – 21.12 Mb
2990:Microprocessor complex
2629:Beta-propeller phytase
2166:10.1074/jbc.M108353200
2058:10.1006/abbi.2001.2513
1972:10.1073/pnas.011512398
1765:10.1128/mcb.13.10.6558
1480:10.1124/mol.104.009423
1468:Molecular Pharmacology
1432:Molecular Pharmacology
724:cAMP catabolic process
489:superior frontal gyrus
447:superior frontal gyrus
427:pancreatic ductal cell
2925:Endodeoxyribonuclease
2822:Iduronate-2-sulfatase
2575:Glucose 6-phosphatase
2361:Butyrylcholinesterase
2020:10.1096/fj.00-0354com
1646:10.1128/MCB.10.6.2678
1172:Clinical significance
493:primary visual cortex
443:primary visual cortex
198:Chromosome 19 (human)
3108:Micrococcal nuclease
2943:Deoxyribonuclease IV
2938:Deoxyribonuclease II
2871:Exodeoxyribonuclease
2531:Alkaline phosphatase
2356:Acetylcholinesterase
1564:Drug Discovery Today
1444:10.1124/mol.59.5.996
1160:subfamily. This PDE
521:olfactory epithelium
300:Chromosome 9 (mouse)
67:List of PDB id codes
40:Available structures
2963:UvrABC endonuclease
2933:Deoxyribonuclease I
2656:Protein phosphatase
2592:Protein phosphatase
2390:Bile salt-dependent
2378:PAF acetylhydrolase
1720:Cellular Signalling
734:signal transduction
509:seminiferous tubule
339:9 A3|9 7.73 cM
3132:, which is in the
3096:Mung bean nuclease
2955:Restriction enzyme
2948:Restriction enzyme
1527:10.1042/BJ20071251
1382:Psychopharmacology
1319:10.1007/BF02290677
1156:(PDE) family, and
869:ENSMUSG00000032177
707:Biological process
656:Cellular component
632:hydrolase activity
610:Molecular function
451:right frontal lobe
3124:
3123:
3120:
3119:
3116:
3115:
2905:
2904:
2897:Oligonucleotidase
2842:deoxyribonuclease
2810:Steroid sulfatase
2685:Phosphodiesterase
2414:Hormone-sensitive
2286:
2285:
2159:(31): 28298–309.
1894:(17): 11796–810.
1854:10.1042/bj3330693
1692:10.1042/bj3080683
1388:(15): 2941–2954.
1128:
1127:
1124:
1123:
1097:
1096:
1062:
1061:
1033:
1032:
991:
990:
962:
961:
920:
919:
901:
900:
875:
874:
856:
855:
830:
829:
811:
810:
759:
758:
642:metal ion binding
594:
593:
590:
589:
545:
544:
532:
531:
513:cerebellar cortex
470:
469:
439:postcentral gyrus
368:
367:
267:
266:
162:PDE4A - orthologs
94:
93:
90:
89:
50:Ortholog search:
3157:
2973:Endoribonuclease
2959:
2953:
2921:
2867:
2853:
2553:Acid phosphatase
2434:Monoacylglycerol
2344:ester hydrolases
2313:
2306:
2299:
2290:
2272:
2252:
2245:
2238:
2229:
2223:
2186:
2168:
2150:
2140:
2122:
2097:
2079:
2069:
2040:
2022:
2004:
1994:
1984:
1974:
1949:
1931:
1921:
1903:
1885:
1875:
1865:
1832:
1814:
1805:(49): 31334–44.
1796:
1786:
1776:
1743:
1713:
1703:
1677:
1667:
1657:
1624:
1587:
1549:
1548:
1538:
1506:
1500:
1499:
1462:
1456:
1455:
1429:
1420:
1414:
1413:
1377:
1371:
1370:
1368:
1367:
1348:
1339:
1338:
1302:
1296:
1295:
1284:
1278:
1277:
1266:
1260:
1250:
1239:
1229:
1110:
1109:
1081:
1074:
1057:
1037:
1028:
1000:
996:RefSeq (protein)
986:
966:
957:
929:
905:
886:
860:
841:
815:
796:
765:
600:
586:
577:
570:
563:
556:
541:
481:
479:Top expressed in
474:
419:
417:Top expressed in
412:
391:
374:
364:
351:
340:
325:
318:
312:
301:
289:
273:
263:
250:
239:
224:
217:
211:
200:
186:
170:
164:
115:
108:
85:
64:
58:
37:
36:
31:
19:
3165:
3164:
3160:
3159:
3158:
3156:
3155:
3154:
3140:
3139:
3125:
3112:
3079:
2967:
2957:
2951:
2914:
2901:
2889:Exoribonuclease
2883:
2860:
2844:
2840:
2831:
2805:Arylsulfatase L
2800:Arylsulfatase B
2795:Arylsulfatase A
2770:
2683:
2674:
2513:
2481:
2343:
2331:
2317:
2287:
2282:
2279:
2273:
2259:
2256:
2226:
2189:
2148:
2143:
2100:
2077:
2072:
2043:
2002:
1997:
1965:(26): 14620–5.
1952:
1929:
1924:
1883:
1878:
1835:
1794:
1789:
1759:(10): 6558–71.
1746:
1716:
1675:
1670:
1627:
1599:(6): 1283–305.
1590:
1570:(22): 1503–19.
1561:
1557:
1555:Further reading
1552:
1508:
1507:
1503:
1464:
1463:
1459:
1438:(5): 996–1011.
1427:
1422:
1421:
1417:
1379:
1378:
1374:
1365:
1363:
1350:
1349:
1342:
1304:
1303:
1299:
1286:
1285:
1281:
1268:
1267:
1263:
1251:
1242:
1230:
1221:
1217:
1174:
1150:
1119:View/Edit Mouse
1114:View/Edit Human
1077:
1070:
1067:Location (UCSC)
1053:
1049:
1045:
1024:
1020:
1016:
1012:
1008:
982:
978:
974:
953:
949:
945:
941:
937:
850:ENSG00000065989
743:
702:
698:plasma membrane
683:cell projection
668:ruffle membrane
651:
627:protein binding
582:
572:
571:
565:
564:
537:
528:
523:
519:
517:right ventricle
515:
511:
507:
505:muscle of thigh
503:
499:
495:
491:
477:
466:
461:
459:cingulate gyrus
457:
455:muscle of thigh
453:
449:
445:
441:
437:
433:
429:
415:
359:
346:
338:
328:
327:
326:
319:
299:
276:Gene location (
258:
245:
237:
227:
226:
225:
218:
196:
173:Gene location (
124:
111:
104:
73:
51:
17:
12:
11:
5:
3163:
3161:
3153:
3152:
3142:
3141:
3122:
3121:
3118:
3117:
3114:
3113:
3111:
3110:
3105:
3100:
3099:
3098:
3087:
3085:
3081:
3080:
3078:
3077:
3072:
3071:
3070:
3065:
3060:
3055:
3045:
3040:
3035:
3030:
3029:
3028:
3023:
3018:
3013:
3003:
3002:
3001:
2992:
2977:
2975:
2969:
2968:
2966:
2965:
2960:
2945:
2940:
2935:
2929:
2927:
2918:
2907:
2906:
2903:
2902:
2900:
2899:
2893:
2891:
2885:
2884:
2882:
2881:
2875:
2873:
2864:
2850:
2833:
2832:
2830:
2829:
2824:
2819:
2814:
2813:
2812:
2807:
2802:
2797:
2784:
2782:
2772:
2771:
2769:
2768:
2763:
2753:
2748:
2739:
2734:
2729:
2724:
2723:
2722:
2712:
2711:
2710:
2705:
2695:
2689:
2687:
2676:
2675:
2673:
2672:
2667:
2662:
2653:
2652:
2651:
2633:
2632:
2631:
2621:
2616:
2611:
2606:
2601:
2600:
2599:
2589:
2588:
2587:
2577:
2572:
2567:
2550:
2549:
2548:
2543:
2538:
2527:
2525:
2515:
2514:
2512:
2511:
2506:
2501:
2495:
2493:
2483:
2482:
2480:
2479:
2474:
2468:
2467:
2466:
2465:
2460:
2455:
2444:
2443:
2442:
2441:
2439:Diacylglycerol
2436:
2431:
2426:
2421:
2416:
2411:
2406:
2401:
2392:
2381:
2380:
2375:
2370:
2368:Pectinesterase
2365:
2364:
2363:
2358:
2351:Cholinesterase
2347:
2345:
2333:
2332:
2318:
2316:
2315:
2308:
2301:
2293:
2284:
2283:
2281:
2280:
2274:
2267:
2264:
2261:
2260:
2257:
2255:
2254:
2247:
2240:
2232:
2225:
2224:
2187:
2141:
2113:(1–3): 205–8.
2098:
2070:
2041:
1995:
1950:
1940:(8): 1745–52.
1922:
1876:
1848:(3): 693–703.
1833:
1787:
1744:
1726:(7): 793–812.
1714:
1668:
1640:(6): 2678–86.
1625:
1588:
1558:
1556:
1553:
1551:
1550:
1501:
1474:(6): 1920–34.
1457:
1415:
1372:
1340:
1297:
1279:
1261:
1240:
1218:
1216:
1213:
1212:
1211:
1194:
1188:
1173:
1170:
1149:
1146:
1126:
1125:
1122:
1121:
1116:
1106:
1105:
1099:
1098:
1095:
1094:
1092:
1090:
1083:
1082:
1075:
1068:
1064:
1063:
1060:
1059:
1041:
1040:
1034:
1031:
1030:
1004:
1003:
997:
993:
992:
989:
988:
970:
969:
963:
960:
959:
933:
932:
926:
922:
921:
918:
917:
909:
908:
902:
899:
898:
890:
889:
883:
877:
876:
873:
872:
864:
863:
857:
854:
853:
845:
844:
838:
832:
831:
828:
827:
819:
818:
812:
809:
808:
800:
799:
793:
787:
786:
781:
776:
772:
771:
761:
760:
757:
756:
745:
744:
742:
741:
736:
731:
726:
721:
716:
710:
708:
704:
703:
701:
700:
695:
690:
685:
680:
675:
670:
665:
659:
657:
653:
652:
650:
649:
644:
639:
634:
629:
624:
619:
613:
611:
607:
606:
596:
595:
592:
591:
588:
587:
579:
578:
553:
547:
546:
543:
542:
534:
533:
530:
529:
527:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
483:
482:
471:
468:
467:
465:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
421:
420:
408:
407:
399:
388:
382:
381:
378:RNA expression
370:
369:
366:
365:
357:
353:
352:
344:
341:
336:
330:
329:
320:
313:
307:
303:
302:
297:
291:
290:
282:
281:
269:
268:
265:
264:
256:
252:
251:
243:
240:
235:
229:
228:
219:
212:
206:
202:
201:
194:
188:
187:
179:
178:
166:
165:
122:
118:
117:
109:
101:
100:
96:
95:
92:
91:
88:
87:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3162:
3151:
3148:
3147:
3145:
3138:
3137:
3135:
3134:public domain
3131:
3109:
3106:
3104:
3101:
3097:
3094:
3093:
3092:
3089:
3088:
3086:
3082:
3076:
3073:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3050:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3027:
3024:
3022:
3019:
3017:
3014:
3012:
3009:
3008:
3007:
3004:
3000:
2996:
2993:
2991:
2987:
2984:
2983:
2982:
2979:
2978:
2976:
2974:
2970:
2964:
2961:
2956:
2949:
2946:
2944:
2941:
2939:
2936:
2934:
2931:
2930:
2928:
2926:
2922:
2919:
2917:
2912:
2908:
2898:
2895:
2894:
2892:
2890:
2886:
2880:
2877:
2876:
2874:
2872:
2868:
2865:
2863:
2858:
2854:
2851:
2848:
2843:
2838:
2834:
2828:
2825:
2823:
2820:
2818:
2815:
2811:
2808:
2806:
2803:
2801:
2798:
2796:
2793:
2792:
2791:
2790:
2789:arylsulfatase
2786:
2785:
2783:
2781:
2777:
2773:
2767:
2764:
2761:
2757:
2754:
2752:
2749:
2747:
2743:
2740:
2738:
2735:
2733:
2730:
2728:
2725:
2721:
2718:
2717:
2716:
2713:
2709:
2706:
2704:
2701:
2700:
2699:
2698:Phospholipase
2696:
2694:
2691:
2690:
2688:
2686:
2681:
2677:
2671:
2668:
2666:
2663:
2661:
2657:
2654:
2650:
2646:
2642:
2639:
2638:
2637:
2634:
2630:
2627:
2626:
2625:
2622:
2620:
2617:
2615:
2612:
2610:
2607:
2605:
2602:
2598:
2595:
2594:
2593:
2590:
2586:
2583:
2582:
2581:
2578:
2576:
2573:
2571:
2568:
2566:
2562:
2558:
2554:
2551:
2547:
2544:
2542:
2539:
2537:
2534:
2533:
2532:
2529:
2528:
2526:
2524:
2520:
2516:
2510:
2507:
2505:
2502:
2500:
2497:
2496:
2494:
2492:
2488:
2484:
2478:
2475:
2473:
2470:
2469:
2464:
2461:
2459:
2456:
2454:
2451:
2450:
2449:
2448:Phospholipase
2446:
2445:
2440:
2437:
2435:
2432:
2430:
2427:
2425:
2422:
2420:
2417:
2415:
2412:
2410:
2407:
2405:
2402:
2400:
2396:
2393:
2391:
2388:
2387:
2386:
2383:
2382:
2379:
2376:
2374:
2371:
2369:
2366:
2362:
2359:
2357:
2354:
2353:
2352:
2349:
2348:
2346:
2342:
2338:
2334:
2329:
2325:
2321:
2314:
2309:
2307:
2302:
2300:
2295:
2294:
2291:
2277:
2271:
2266:
2262:
2253:
2248:
2246:
2241:
2239:
2234:
2233:
2230:
2221:
2217:
2213:
2209:
2205:
2201:
2198:(3): 301–11.
2197:
2193:
2188:
2184:
2180:
2176:
2172:
2167:
2162:
2158:
2154:
2147:
2142:
2138:
2134:
2130:
2126:
2121:
2116:
2112:
2108:
2104:
2099:
2095:
2091:
2088:(2): 589–95.
2087:
2083:
2076:
2071:
2067:
2063:
2059:
2055:
2051:
2047:
2042:
2038:
2034:
2030:
2026:
2021:
2016:
2013:(2): 483–91.
2012:
2008:
2007:FASEB Journal
2001:
1996:
1992:
1988:
1983:
1978:
1973:
1968:
1964:
1960:
1956:
1951:
1947:
1943:
1939:
1935:
1928:
1923:
1919:
1915:
1911:
1907:
1902:
1897:
1893:
1889:
1882:
1877:
1873:
1869:
1864:
1859:
1855:
1851:
1847:
1843:
1839:
1834:
1830:
1826:
1822:
1818:
1813:
1808:
1804:
1800:
1793:
1788:
1784:
1780:
1775:
1770:
1766:
1762:
1758:
1754:
1750:
1745:
1741:
1737:
1733:
1729:
1725:
1721:
1715:
1711:
1707:
1702:
1697:
1693:
1689:
1686:(2): 683–91.
1685:
1681:
1674:
1669:
1665:
1661:
1656:
1651:
1647:
1643:
1639:
1635:
1631:
1626:
1622:
1618:
1614:
1610:
1606:
1602:
1598:
1594:
1589:
1585:
1581:
1577:
1573:
1569:
1565:
1560:
1559:
1554:
1546:
1542:
1537:
1532:
1528:
1524:
1520:
1516:
1512:
1505:
1502:
1497:
1493:
1489:
1485:
1481:
1477:
1473:
1469:
1461:
1458:
1453:
1449:
1445:
1441:
1437:
1433:
1426:
1419:
1416:
1411:
1407:
1403:
1399:
1395:
1391:
1387:
1383:
1376:
1373:
1361:
1357:
1355:
1347:
1345:
1341:
1336:
1332:
1328:
1324:
1320:
1316:
1312:
1308:
1301:
1298:
1293:
1289:
1283:
1280:
1275:
1271:
1265:
1262:
1258:
1254:
1249:
1247:
1245:
1241:
1237:
1233:
1228:
1226:
1224:
1220:
1214:
1210:
1206:
1202:
1198:
1195:
1192:
1189:
1186:
1182:
1179:
1178:
1177:
1171:
1169:
1167:
1163:
1159:
1155:
1147:
1145:
1143:
1140:
1136:
1132:
1120:
1115:
1111:
1107:
1104:
1100:
1093:
1091:
1088:
1084:
1080:
1076:
1073:
1069:
1065:
1058:
1056:
1052:
1048:
1042:
1038:
1035:
1029:
1027:
1023:
1019:
1015:
1011:
1005:
1001:
998:
994:
987:
985:
981:
977:
971:
967:
964:
958:
956:
952:
948:
944:
940:
934:
930:
927:
925:RefSeq (mRNA)
923:
916:
915:
910:
906:
903:
897:
896:
891:
887:
884:
882:
878:
871:
870:
865:
861:
858:
852:
851:
846:
842:
839:
837:
833:
826:
825:
820:
816:
813:
807:
806:
801:
797:
794:
792:
788:
785:
782:
780:
777:
773:
770:
766:
762:
755:
751:
746:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
711:
709:
706:
705:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
660:
658:
655:
654:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
614:
612:
609:
608:
605:
604:Gene ontology
601:
597:
585:
580:
576:
569:
562:
557:
554:
552:
548:
540:
535:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
487:
484:
480:
475:
472:
462:
458:
454:
450:
446:
442:
438:
435:parietal lobe
434:
430:
426:
425:
422:
418:
413:
410:
409:
406:
404:
400:
398:
397:
393:
392:
389:
387:
383:
379:
375:
371:
363:
358:
354:
350:
345:
335:
331:
324:
317:
311:
304:
296:
292:
288:
283:
279:
274:
270:
262:
257:
253:
249:
244:
234:
230:
223:
216:
210:
203:
199:
193:
189:
185:
180:
176:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
119:
114:
107:
102:
97:
86:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
3127:
3126:
2958:}}
2952:{{
2916:Endonuclease
2847:ribonuclease
2787:
2741:
2570:Nucleotidase
2491:Thioesterase
2275:
2195:
2191:
2156:
2152:
2110:
2107:FEBS Letters
2106:
2085:
2081:
2052:(1): 54–60.
2049:
2045:
2010:
2006:
1962:
1958:
1937:
1933:
1891:
1887:
1845:
1841:
1802:
1798:
1756:
1752:
1723:
1719:
1683:
1679:
1637:
1633:
1596:
1592:
1567:
1563:
1521:(2): 361–9.
1518:
1514:
1504:
1471:
1467:
1460:
1435:
1431:
1418:
1385:
1381:
1375:
1364:. Retrieved
1362:. 2012-03-04
1359:
1354:Homo sapiens
1353:
1313:(2): 75–86.
1310:
1306:
1300:
1291:
1282:
1273:
1264:
1175:
1151:
1138:
1130:
1129:
1047:NP_001297679
1044:
1022:NP_001230050
1018:NP_001104779
1014:NP_001104778
1010:NP_001104777
1007:
984:NM_001310750
973:
951:NM_001243121
947:NM_001111309
943:NM_001111308
939:NM_001111307
936:
912:
893:
867:
848:
822:
803:
783:
778:
622:cAMP binding
401:
394:
121:External IDs
72:
3091:Nuclease S1
2862:Exonuclease
2756:Lecithinase
2585:Calcineurin
2523:Phosphatase
2429:Lipoprotein
2419:Endothelial
2258:PDB gallery
1360:Entrez Gene
1191:roflumilast
693:nucleoplasm
360:21,124,544
347:21,077,010
259:10,469,630
246:10,416,773
99:Identifiers
2404:Pancreatic
2341:Carboxylic
1366:2012-04-02
1259:, May 2017
1238:, May 2017
1215:References
1185:cilomilast
1162:hydrolyzes
405:(ortholog)
142:HomoloGene
2981:RNase III
2839:(includes
2780:Sulfatase
2693:Autotaxin
2557:Prostatic
2409:Lysosomal
2324:esterases
2320:Hydrolase
1197:tofisopam
1055:NP_899668
1051:NP_062772
1026:NP_006193
980:NM_183408
976:NM_019798
955:NM_006202
769:Orthologs
663:cytoplasm
501:spermatid
150:GeneCards
3144:Category
3075:RNase T1
2837:Nuclease
2472:Cutinase
2212:12764607
2183:21243391
2175:11994273
2137:27637592
2129:11852080
2094:11839681
2066:11566027
2037:26315564
2029:11156964
1991:11114167
1946:10393044
1918:42776400
1910:10206997
1829:25157712
1621:46276184
1613:16300476
1584:16257373
1545:18095939
1488:15738310
1452:11306681
1410:13542300
1402:24563185
1335:19182571
1255:–
1234:–
1201:PDE-10A1
1181:rolipram
1148:Function
1103:Wikidata
748:Sources:
688:membrane
3048:RNase E
3043:RNase Z
3038:RNase A
3033:RNase P
3006:RNase H
2624:Phytase
2424:Hepatic
2399:Lingual
2395:Gastric
2220:8501967
1872:9677330
1863:1219634
1821:8940140
1783:8413254
1740:7888306
1710:7772058
1701:1136980
1664:2160582
1536:4337886
1496:1758221
1466:gene".
1327:8009369
1257:Ensembl
1236:Ensembl
1209:PDE-2A3
881:UniProt
836:Ensembl
775:Species
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