318:
295:
192:
217:
1179:. Additionally, the ATP-binding loop in one PDK3 subunit adopts an open conformation, implying that the nucleotide loading into the active site is mediated by the inactive "pre-insertion" binding mode. This asymmetric complex represents a physiological state in which binding of a single L2-domain activates one of the PDHK subunits while inactivating another. Thus, the L2-domains likely act not only as the structural anchors but also modulate the catalytic cycle of PDK3.
569:
576:
324:
223:
29:
2277:
2262:
2247:
4454:
1153:/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the four pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles.
1187:
The
Pyruvate Dehydrogenase (PDH) complex must be tightly regulated due to its central role in general metabolism. Within the complex, there are three serine residues on the E1 component that are sites for phosphorylation; this phosphorylation inactivates the complex. In humans, there have been four
1174:
domain that are crucial for this interaction. Structural studies have indicated that L2 binding stimulates activity by disrupting the closed conformation, or ATP lid, to remove product inhibition. The PDK3 subunits are in one of two conformations; one subunit exists as an “open” subunit, while the
2007:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P,
1212:
As the primary regulators of a crucial step in the central metabolic pathway, the pyruvate dehydrogenase family is tightly regulated itself by a myriad of factors. PDK3, in conjunction with PDK2 and PDK4, are primary targets of peroxisome proliferator-activated receptor delta/beta
1169:
The structure of the PDK3/L2 complex has been elucidated, and there are several key features. When the L2 domain binds to PDK3, it induces a “cross-tail” conformation in PDK3, thereby stimulating activity. There are three crucial residues, Leu-140, Glu-170, and Glu-179, in the
55:
2131:
Degenhardt T, Saramäki A, Malinen M, Rieck M, Väisänen S, Huotari A, Herzig KH, Müller R, Carlberg C (Sep 2007). "Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta".
1592:
Degenhardt T, Saramäki A, Malinen M, Rieck M, Väisänen S, Huotari A, Herzig KH, Müller R, Carlberg C (Sep 2007). "Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta".
1175:
other subunit is “closed”. The open subunit is the configuration most crucial to the putative substrate-binding cleft, as it is where the target peptide can access the active center. The closed subunit blocks this target peptide because of a neighboring unwound
2008:
Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
2317:
2602:
2310:
1827:"Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex"
2303:
2510:
331:
230:
1214:
1919:
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL (Sep 2004).
3058:
3897:
2361:
4006:
1869:
1662:
2744:
2631:
829:
153:
3019:
810:
3992:
3457:
2348:
2330:
4094:
3975:
2055:"Structural determinants for cross-talk between pyruvate dehydrogenase kinase 3 and lipoyl domain 2 of the human pyruvate dehydrogenase complex"
1371:"Structural determinants for cross-talk between pyruvate dehydrogenase kinase 3 and lipoyl domain 2 of the human pyruvate dehydrogenase complex"
3681:
2550:
1632:
Sugden MC, Holness MJ (Jul 2002). "Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia".
1557:
Sugden MC, Holness MJ (Jul 2002). "Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia".
1293:
3745:
2720:
2226:
1275:
4474:
4001:
1792:"Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase"
1122:.The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of
2535:
317:
4058:
3733:
1037:
4173:
2990:
2980:
2665:
2163:"Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol"
2090:"Crystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implications"
1461:"Crystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implications"
1044:
294:
3672:
2276:
2261:
2246:
1355:
3941:
3613:
2975:
2966:
1262:
1241:
4329:
1258:
216:
191:
52:
3356:
2853:
2844:
2501:
2447:
1119:
4444:
1237:
2544:
133:
1966:"Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex"
1663:"Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs"
1412:"Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex"
2295:
330:
229:
3568:
3386:
2882:
4314:
4430:
4417:
4404:
4391:
4378:
4365:
4352:
3558:
3553:
3548:
3538:
3533:
3528:
3518:
3313:
3088:
2684:
2219:
323:
222:
4324:
1908:
1701:
4278:
4221:
3781:
3772:
3723:
2489:
2334:
874:
141:
4226:
4081:
3504:
1146:
855:
4247:
4166:
2780:
4319:
3347:
2212:
2017:
1154:
205:
120:
4283:
995:
948:
3855:
4479:
4216:
3958:
3912:
2041:
1900:
1870:"Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting"
1693:
165:
1020:
999:
969:
944:
3218:
2927:
2192:
2149:
2119:
2076:
2033:
1995:
1952:
1892:
1856:
1813:
1778:
1735:
1685:
1649:
1610:
1574:
1539:
1490:
1441:
1392:
1334:
113:
45:
4262:
4257:
4231:
4159:
3811:
3053:
3043:
3038:
2956:
2947:
2877:
2868:
2814:
2805:
2462:
2182:
2174:
2141:
2109:
2101:
2066:
2025:
1985:
1977:
1942:
1932:
1884:
1846:
1838:
1803:
1768:
1760:
1725:
1677:
1641:
1602:
1566:
1529:
1521:
1480:
1472:
1431:
1423:
1382:
1324:
568:
410:
341:
285:
240:
4309:
4293:
4206:
3637:
2708:
2703:
2698:
1192:
of
Pyruvate Dehydrogenase Kinase that have been shown to phosphorylate these three sites:
1158:
1150:
575:
385:
161:
1749:"Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites"
1510:"Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites"
2021:
4458:
4347:
4288:
2187:
2162:
2114:
2089:
1990:
1965:
1851:
1826:
1773:
1748:
1534:
1509:
1485:
1460:
1436:
1411:
1131:
1947:
1920:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
678:
673:
668:
652:
647:
642:
637:
632:
627:
622:
617:
28:
4468:
4252:
4211:
2761:
2693:
1868:
Spriet LL, Tunstall RJ, Watt MJ, Mehan KA, Hargreaves M, Cameron-Smith D (Jun 2004).
604:
1904:
1888:
1697:
145:
4201:
3632:
2457:
2045:
403:
182:
1937:
169:
4425:
4360:
4196:
3838:
3470:
3410:
3293:
3213:
2937:
1764:
1714:"Marked differences between two isoforms of human pyruvate dehydrogenase kinase"
1570:
1525:
1298:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1280:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1176:
4453:
1681:
486:
3926:
2400:
2178:
2145:
2105:
1606:
1476:
1171:
1138:
1127:
302:
199:
149:
1981:
1645:
1427:
1329:
1312:
4399:
4373:
2887:
1142:
1098:
774:
546:
424:
369:
356:
268:
255:
157:
2196:
2153:
2123:
2080:
2071:
2054:
2037:
1999:
1956:
1896:
1860:
1817:
1808:
1791:
1782:
1739:
1730:
1713:
1689:
1653:
1614:
1578:
1543:
1494:
1445:
1396:
1387:
1370:
1338:
1084:
1079:
3243:
3138:
3133:
3128:
1189:
1145:, and thus is one of the major enzymes responsible for the regulation of
1123:
1068:
919:
900:
2029:
1204:. The PDK3 protein is primarily found in the kidney, brain, and testis.
3902:
3880:
3875:
3865:
3860:
3662:
3657:
3652:
3647:
3642:
3627:
3622:
3273:
3238:
2477:
2472:
2467:
1842:
1115:
886:
841:
1313:"Diversity of the pyruvate dehydrogenase kinase gene family in humans"
1311:
Gudi R, Bowker-Kinley MM, Kedishvili NY, Zhao Y, Popov KM (Dec 1995).
90:
86:
82:
78:
74:
4412:
4182:
4132:
4127:
4122:
4117:
4112:
4107:
4102:
4053:
4048:
4043:
4038:
4033:
4016:
4011:
3885:
3870:
3821:
3816:
3801:
3796:
3791:
3786:
3760:
3755:
3750:
3738:
3716:
3711:
3603:
3578:
3253:
3078:
3073:
3068:
3063:
3048:
2892:
2829:
2824:
2819:
2795:
2621:
2616:
2590:
2585:
2580:
2570:
2565:
2555:
2395:
2326:
1104:
1052:
796:
1217:), with PDK3 having five elements that respond to these receptors.
4386:
4028:
4021:
3931:
3828:
3728:
3706:
3701:
3696:
3691:
3686:
3598:
3593:
3588:
3583:
3573:
3543:
3523:
3400:
3395:
3376:
3371:
3361:
3337:
3332:
3327:
3303:
3298:
3288:
3283:
3278:
3268:
3248:
3233:
3228:
3223:
3203:
3198:
3188:
3183:
3178:
3173:
3168:
3158:
3153:
3148:
3143:
3123:
3118:
3113:
3108:
3103:
3098:
3083:
3033:
3028:
2922:
2917:
2912:
2907:
2902:
2897:
2858:
2790:
2785:
2734:
2729:
2655:
2650:
2645:
2611:
2603:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
2405:
2390:
2385:
2380:
2375:
2370:
759:
755:
3921:
3848:
3843:
3833:
3806:
3563:
3513:
3494:
3489:
3484:
3479:
3434:
3429:
3424:
3419:
3366:
3322:
3263:
3258:
3208:
3193:
3163:
3093:
3009:
3004:
2999:
2932:
2834:
2775:
2770:
2674:
2640:
2525:
2515:
2484:
2452:
2440:
2435:
2430:
2420:
2415:
1201:
1197:
1193:
1111:
137:
4155:
4079:
3455:
2346:
2299:
2208:
1634:
Current Drug
Targets. Immune, Endocrine and Metabolic Disorders
1559:
Current Drug
Targets. Immune, Endocrine and Metabolic Disorders
584:
3890:
2425:
2410:
2204:
1747:
Kolobova E, Tuganova A, Boulatnikov I, Popov KM (Aug 2001).
1670:
American
Journal of Physiology. Endocrinology and Metabolism
1508:
Kolobova E, Tuganova A, Boulatnikov I, Popov KM (Aug 2001).
1356:"Entrez Gene: PDK3 pyruvate dehydrogenase kinase, isozyme 3"
700:
peroxisome proliferator activated receptor signaling pathway
653:
pyruvate dehydrogenase (acetyl-transferring) kinase activity
715:
regulation of acetyl-CoA biosynthetic process from pyruvate
4151:
1964:
Kato M, Chuang JL, Tso SC, Wynn RM, Chuang DT (May 2005).
1410:
Kato M, Chuang JL, Tso SC, Wynn RM, Chuang DT (May 2005).
1712:
Baker JC, Yan X, Peng T, Kasten S, Roche TE (May 2000).
393:
710:
regulation of reactive oxygen species metabolic process
4442:
558:
124:, CMTX6, GS1-358P8.4, pyruvate dehydrogenase kinase 3
4338:
4302:
4271:
4240:
4189:
4093:
3991:
3974:
3957:
3940:
3911:
3771:
3671:
3612:
3503:
3469:
3409:
3385:
3346:
3312:
3018:
2989:
2965:
2946:
2867:
2843:
2804:
2760:
2743:
2719:
2683:
2664:
2630:
2601:
2534:
2500:
2360:
1013:
988:
962:
937:
2088:Devedjiev Y, Steussy CN, Vassylyev DG (Jul 2007).
1459:Devedjiev Y, Steussy CN, Vassylyev DG (Jul 2007).
1254:
1252:
1250:
1233:
1231:
1229:
1149:. The enzymatic activity of PDH is regulated by a
2053:Tso SC, Kato M, Chuang JL, Chuang DT (Sep 2006).
1369:Tso SC, Kato M, Chuang JL, Chuang DT (Sep 2006).
705:hypoxia-inducible factor-1alpha signaling pathway
340:
239:
1825:Tuganova A, Boulatnikov I, Popov KM (Aug 2002).
2161:Kato M, Li J, Chuang JL, Chuang DT (Aug 2007).
1921:"Genomic analysis of mouse retinal development"
16:Protein-coding gene in the species Homo sapiens
1259:GRCm38: Ensembl release 89: ENSMUSG00000035232
4167:
2362:Non-specific serine/threonine protein kinases
2311:
2220:
8:
1238:GRCh38: Ensembl release 89: ENSG00000067992
4174:
4160:
4152:
4090:
4076:
3466:
3452:
2745:Goodpasture-antigen-binding protein kinase
2357:
2343:
2318:
2304:
2296:
2285:: Crystal structure of the PDK3-L2 complex
2270:: Crystal structure of the PDK3-L2 complex
2255:: Crystal structure of the PDK3-L2 complex
2227:
2213:
2205:
770:
600:
381:
280:
177:
63:
3458:Serine/threonine-specific protein kinases
2632:(isocitrate dehydrogenase (NADP+)) kinase
2349:Serine/threonine-specific protein kinases
2331:Serine/threonine-specific protein kinases
2186:
2113:
2070:
1989:
1946:
1936:
1850:
1807:
1772:
1729:
1533:
1484:
1435:
1386:
1328:
533:fetal liver hematopoietic progenitor cell
3993:Receptor protein serine/threonine kinase
1350:
1348:
638:protein serine/threonine kinase activity
4449:
3976:Low-density-lipoprotein receptor kinase
2242:
1225:
1157:transcript variants encoding different
1137:. It provides the primary link between
720:regulation of glucose metabolic process
18:
2721:Fas-activated serine/threonine kinase
1790:Korotchkina LG, Patel MS (Oct 2001).
740:cellular response to glucose stimulus
345:
306:
301:
244:
203:
198:
7:
4002:Bone morphogenetic protein receptors
2536:Dephospho-(reductase kinase) kinase
2059:The Journal of Biological Chemistry
1796:The Journal of Biological Chemistry
1718:The Journal of Biological Chemistry
1375:The Journal of Biological Chemistry
1317:The Journal of Biological Chemistry
2991:G-protein coupled receptor kinases
1661:Sugden MC, Holness MJ (May 2003).
1010:
985:
959:
934:
910:
891:
865:
846:
820:
801:
563:
521:choroid plexus of fourth ventricle
481:
419:
398:
14:
2981:Beta adrenergic receptor kinase-2
2666:(tyrosine 3-monooxygenase) kinase
1107:that in humans is encoded by the
451:lateral nuclear group of thalamus
4452:
3673:Mitogen-activated protein kinase
2275:
2260:
2245:
574:
567:
329:
322:
316:
293:
228:
221:
215:
190:
27:
4059:Anti-MĂĽllerian hormone receptor
3942:(acetyl-CoA carboxylase) kinase
3614:(RNA-polymerase)-subunit kinase
2976:Beta adrenergic receptor kinase
2967:Beta adrenergic receptor kinase
1889:10.1152/japplphysiol.01318.2003
1161:have been found for this gene.
1101:kinase isozyme 3, mitochondrial
730:peptidyl-serine phosphorylation
725:cellular response to fatty acid
3682:Extracellular signal-regulated
1143:tricarboxylic acid (TCA) cycle
745:carbohydrate metabolic process
585:More reference expression data
547:More reference expression data
1:
3746:P38 mitogen-activated protein
2845:cGMP-dependent protein kinase
2806:cAMP-dependent protein kinase
2502:Pyruvate dehydrogenase kinase
2448:Ataxia telangiectasia mutated
1877:Journal of Applied Physiology
1120:pyruvate dehydrogenase kinase
314:
213:
2545:AMP-activated protein kinase
2134:Journal of Molecular Biology
2094:Journal of Molecular Biology
1938:10.1371/journal.pbio.0020247
1595:Journal of Molecular Biology
1465:Journal of Molecular Biology
4475:Genes on human chromosome X
3460:(EC 2.7.11.21-EC 2.7.11.30)
1571:10.2174/1568005310202020151
4496:
3387:Elongation factor 2 kinase
2351:(EC 2.7.11.1-EC 2.7.11.20)
1682:10.1152/ajpendo.00526.2002
4330:Michaelis–Menten kinetics
4089:
4075:
3782:MAP kinase kinase kinases
3465:
3451:
3314:Myosin light-chain kinase
3020:Ca2+/calmodulin-dependent
2685:Myosin-heavy-chain kinase
2356:
2342:
2240:
2179:10.1016/j.str.2007.07.001
2146:10.1016/j.jmb.2007.06.091
2106:10.1016/j.jmb.2007.04.083
1765:10.1042/0264-6021:3580069
1607:10.1016/j.jmb.2007.06.091
1526:10.1042/0264-6021:3580069
1477:10.1016/j.jmb.2007.04.083
1294:"Mouse PubMed Reference:"
1276:"Human PubMed Reference:"
1083:
1078:
1074:
1067:
1051:
1032:
1017:
992:
981:
966:
941:
930:
917:
913:
898:
894:
885:
872:
868:
853:
849:
840:
827:
823:
808:
804:
795:
780:
773:
769:
753:
735:glucose metabolic process
603:
599:
582:
566:
557:
544:
493:
484:
431:
422:
392:
384:
380:
363:
350:
313:
292:
283:
279:
262:
249:
212:
189:
180:
176:
131:
128:
118:
111:
106:
71:
66:
49:
44:
39:
35:
26:
21:
4222:Diffusion-limited enzyme
4082:Dual-specificity kinases
1982:10.1038/sj.emboj.7600663
1646:10.2174/1568008023340785
1428:10.1038/sj.emboj.7600663
1330:10.1074/jbc.270.48.28989
3505:Cyclin-dependent kinase
1831:The Biochemical Journal
1753:The Biochemical Journal
1514:The Biochemical Journal
1097:Pyruvate dehydrogenase
1045:Chr X: 92.81 – 92.88 Mb
1038:Chr X: 24.47 – 24.55 Mb
628:protein kinase activity
2072:10.1074/jbc.M604339200
1809:10.1074/jbc.M103069200
1731:10.1074/jbc.M909488199
1388:10.1074/jbc.M604339200
4315:Eadie–Hofstee diagram
4248:Allosteric regulation
1155:Alternatively spliced
435:middle temporal gyrus
4325:Lineweaver–Burk plot
3348:Phosphorylase kinase
669:mitochondrial matrix
618:transferase activity
308:X chromosome (mouse)
206:X chromosome (human)
67:List of PDB id codes
40:Available structures
2030:10.1038/nature04209
2022:2005Natur.437.1173R
1114:. It codes for an
509:seminiferous tubule
505:endocardial cushion
4284:Enzyme superfamily
4217:Enzyme promiscuity
3959:Tropomyosin kinase
3913:Tau-protein kinase
1843:10.1042/BJ20020301
1147:glucose metabolism
875:ENSMUSG00000035232
688:Biological process
662:Cellular component
623:nucleotide binding
611:Molecular function
4440:
4439:
4149:
4148:
4145:
4144:
4141:
4140:
4071:
4070:
4067:
4066:
3447:
3446:
3443:
3442:
2928:Protein kinase N1
2883:Protein kinase Cζ
2293:
2292:
2065:(37): 27197–204.
1381:(37): 27197–204.
1094:
1093:
1090:
1089:
1063:
1062:
1028:
1027:
1007:
1006:
977:
976:
956:
955:
926:
925:
907:
906:
881:
880:
862:
861:
836:
835:
817:
816:
765:
764:
595:
594:
591:
590:
553:
552:
540:
539:
478:
477:
443:corpus epididymis
376:
375:
275:
274:
102:
101:
98:
97:
50:Ortholog search:
4487:
4457:
4456:
4448:
4320:Hanes–Woolf plot
4263:Enzyme activator
4258:Enzyme inhibitor
4232:Enzyme catalysis
4176:
4169:
4162:
4153:
4091:
4077:
3724:C-Jun N-terminal
3467:
3453:
2957:Rhodopsin kinase
2948:Rhodopsin kinase
2878:Protein kinase C
2869:Protein kinase C
2854:Protein kinase G
2815:Protein kinase A
2426:Protein kinase B
2358:
2344:
2320:
2313:
2306:
2297:
2279:
2264:
2249:
2229:
2222:
2215:
2206:
2200:
2190:
2157:
2127:
2117:
2084:
2074:
2049:
2016:(7062): 1173–8.
2003:
1993:
1970:The EMBO Journal
1960:
1950:
1940:
1915:
1913:
1907:. Archived from
1883:(6): 2082–2087.
1874:
1864:
1854:
1837:(Pt 1): 129–36.
1821:
1811:
1786:
1776:
1743:
1733:
1724:(21): 15773–81.
1708:
1706:
1700:. Archived from
1667:
1657:
1619:
1618:
1589:
1583:
1582:
1554:
1548:
1547:
1537:
1505:
1499:
1498:
1488:
1456:
1450:
1449:
1439:
1416:The EMBO Journal
1407:
1401:
1400:
1390:
1366:
1360:
1359:
1352:
1343:
1342:
1332:
1323:(48): 28989–94.
1308:
1302:
1301:
1290:
1284:
1283:
1272:
1266:
1256:
1245:
1235:
1076:
1075:
1047:
1040:
1023:
1011:
1002:
986:
982:RefSeq (protein)
972:
960:
951:
935:
911:
892:
866:
847:
821:
802:
771:
601:
587:
578:
571:
564:
549:
489:
487:Top expressed in
482:
467:endothelial cell
459:caput epididymis
439:Brodmann area 23
427:
425:Top expressed in
420:
399:
382:
372:
359:
348:
333:
326:
320:
309:
297:
281:
271:
258:
247:
232:
225:
219:
208:
194:
178:
172:
170:PDK3 - orthologs
123:
116:
93:
64:
58:
37:
36:
31:
19:
4495:
4494:
4490:
4489:
4488:
4486:
4485:
4484:
4465:
4464:
4463:
4451:
4443:
4441:
4436:
4348:Oxidoreductases
4334:
4310:Enzyme kinetics
4298:
4294:List of enzymes
4267:
4236:
4207:Catalytic triad
4185:
4180:
4150:
4137:
4085:
4063:
3987:
3970:
3953:
3936:
3907:
3767:
3667:
3638:P70-S6 Kinase 1
3608:
3499:
3461:
3439:
3405:
3381:
3342:
3308:
3014:
2985:
2961:
2942:
2863:
2839:
2800:
2756:
2739:
2715:
2709:Aurora C kinase
2704:Aurora B kinase
2699:Aurora A kinase
2679:
2660:
2626:
2597:
2530:
2496:
2352:
2338:
2324:
2294:
2289:
2286:
2280:
2271:
2265:
2256:
2250:
2236:
2233:
2203:
2173:(8): 992–1004.
2160:
2130:
2087:
2052:
2006:
1976:(10): 1763–74.
1963:
1918:
1911:
1872:
1867:
1824:
1802:(40): 37223–9.
1789:
1759:(Pt 1): 69–77.
1746:
1711:
1704:
1665:
1660:
1631:
1627:
1625:Further reading
1622:
1591:
1590:
1586:
1556:
1555:
1551:
1520:(Pt 1): 69–77.
1507:
1506:
1502:
1458:
1457:
1453:
1422:(10): 1763–74.
1409:
1408:
1404:
1368:
1367:
1363:
1354:
1353:
1346:
1310:
1309:
1305:
1292:
1291:
1287:
1274:
1273:
1269:
1257:
1248:
1236:
1227:
1223:
1215:PPAR beta/delta
1210:
1185:
1167:
1151:phosphorylation
1135:
1085:View/Edit Mouse
1080:View/Edit Human
1043:
1036:
1033:Location (UCSC)
1019:
998:
994:
968:
947:
943:
856:ENSG00000067992
749:
695:phosphorylation
683:
657:
643:protein binding
633:kinase activity
583:
573:
572:
545:
536:
531:
527:
523:
519:
515:
513:proximal tubule
511:
507:
503:
499:
485:
474:
469:
465:
461:
457:
453:
449:
445:
441:
437:
423:
367:
354:
346:
336:
335:
334:
327:
307:
284:Gene location (
266:
253:
245:
235:
234:
233:
226:
204:
181:Gene location (
132:
119:
112:
73:
51:
17:
12:
11:
5:
4493:
4491:
4483:
4482:
4477:
4467:
4466:
4462:
4461:
4438:
4437:
4435:
4434:
4421:
4408:
4395:
4382:
4369:
4356:
4342:
4340:
4336:
4335:
4333:
4332:
4327:
4322:
4317:
4312:
4306:
4304:
4300:
4299:
4297:
4296:
4291:
4286:
4281:
4275:
4273:
4272:Classification
4269:
4268:
4266:
4265:
4260:
4255:
4250:
4244:
4242:
4238:
4237:
4235:
4234:
4229:
4224:
4219:
4214:
4209:
4204:
4199:
4193:
4191:
4187:
4186:
4181:
4179:
4178:
4171:
4164:
4156:
4147:
4146:
4143:
4142:
4139:
4138:
4136:
4135:
4130:
4125:
4120:
4115:
4110:
4105:
4099:
4097:
4087:
4086:
4080:
4073:
4072:
4069:
4068:
4065:
4064:
4062:
4061:
4056:
4051:
4046:
4041:
4036:
4031:
4026:
4025:
4024:
4019:
4014:
4009:
3998:
3996:
3995:(EC 2.7.11.30)
3989:
3988:
3986:
3985:
3981:
3979:
3978:(EC 2.7.11.29)
3972:
3971:
3969:
3968:
3964:
3962:
3961:(EC 2.7.11.28)
3955:
3954:
3952:
3951:
3947:
3945:
3944:(EC 2.7.11.27)
3938:
3937:
3935:
3934:
3929:
3924:
3918:
3916:
3915:(EC 2.7.11.26)
3909:
3908:
3906:
3905:
3900:
3895:
3894:
3893:
3888:
3883:
3878:
3873:
3868:
3863:
3853:
3852:
3851:
3846:
3841:
3836:
3826:
3825:
3824:
3819:
3814:
3809:
3804:
3799:
3794:
3789:
3778:
3776:
3775:(EC 2.7.11.25)
3769:
3768:
3766:
3765:
3764:
3763:
3758:
3753:
3743:
3742:
3741:
3736:
3731:
3721:
3720:
3719:
3714:
3709:
3704:
3699:
3694:
3689:
3678:
3676:
3675:(EC 2.7.11.24)
3669:
3668:
3666:
3665:
3660:
3655:
3650:
3645:
3640:
3635:
3630:
3625:
3619:
3617:
3616:(EC 2.7.11.23)
3610:
3609:
3607:
3606:
3601:
3596:
3591:
3586:
3581:
3576:
3571:
3566:
3561:
3556:
3551:
3546:
3541:
3536:
3531:
3526:
3521:
3516:
3510:
3508:
3507:(EC 2.7.11.22)
3501:
3500:
3498:
3497:
3492:
3487:
3482:
3476:
3474:
3473:(EC 2.7.11.21)
3463:
3462:
3456:
3449:
3448:
3445:
3444:
3441:
3440:
3438:
3437:
3432:
3427:
3422:
3416:
3414:
3413:(EC 2.7.11.21)
3407:
3406:
3404:
3403:
3398:
3392:
3390:
3389:(EC 2.7.11.20)
3383:
3382:
3380:
3379:
3374:
3369:
3364:
3359:
3353:
3351:
3350:(EC 2.7.11.19)
3344:
3343:
3341:
3340:
3335:
3330:
3325:
3319:
3317:
3316:(EC 2.7.11.18)
3310:
3309:
3307:
3306:
3301:
3296:
3291:
3286:
3281:
3276:
3271:
3266:
3261:
3256:
3251:
3246:
3241:
3236:
3231:
3226:
3221:
3216:
3211:
3206:
3201:
3196:
3191:
3186:
3181:
3176:
3171:
3166:
3161:
3156:
3151:
3146:
3141:
3136:
3131:
3126:
3121:
3116:
3111:
3106:
3101:
3096:
3091:
3086:
3081:
3076:
3071:
3066:
3061:
3056:
3051:
3046:
3041:
3036:
3031:
3025:
3023:
3022:(EC 2.7.11.17)
3016:
3015:
3013:
3012:
3007:
3002:
2996:
2994:
2993:(EC 2.7.11.16)
2987:
2986:
2984:
2983:
2978:
2972:
2970:
2969:(EC 2.7.11.15)
2963:
2962:
2960:
2959:
2953:
2951:
2950:(EC 2.7.11.14)
2944:
2943:
2941:
2940:
2935:
2930:
2925:
2920:
2915:
2910:
2905:
2900:
2895:
2890:
2885:
2880:
2874:
2872:
2871:(EC 2.7.11.13)
2865:
2864:
2862:
2861:
2856:
2850:
2848:
2847:(EC 2.7.11.12)
2841:
2840:
2838:
2837:
2832:
2827:
2822:
2817:
2811:
2809:
2808:(EC 2.7.11.11)
2802:
2801:
2799:
2798:
2793:
2788:
2783:
2778:
2773:
2767:
2765:
2764:(EC 2.7.11.10)
2758:
2757:
2755:
2754:
2750:
2748:
2741:
2740:
2738:
2737:
2732:
2726:
2724:
2717:
2716:
2714:
2713:
2712:
2711:
2706:
2701:
2690:
2688:
2681:
2680:
2678:
2677:
2671:
2669:
2662:
2661:
2659:
2658:
2653:
2648:
2643:
2637:
2635:
2628:
2627:
2625:
2624:
2619:
2614:
2608:
2606:
2599:
2598:
2596:
2595:
2594:
2593:
2588:
2583:
2575:
2574:
2573:
2568:
2560:
2559:
2558:
2553:
2541:
2539:
2532:
2531:
2529:
2528:
2523:
2518:
2513:
2507:
2505:
2498:
2497:
2495:
2494:
2493:
2492:
2482:
2481:
2480:
2475:
2470:
2465:
2455:
2450:
2445:
2444:
2443:
2438:
2433:
2423:
2418:
2413:
2408:
2403:
2398:
2393:
2388:
2383:
2378:
2373:
2367:
2365:
2354:
2353:
2347:
2340:
2339:
2325:
2323:
2322:
2315:
2308:
2300:
2291:
2290:
2288:
2287:
2281:
2274:
2272:
2266:
2259:
2257:
2251:
2244:
2241:
2238:
2237:
2234:
2232:
2231:
2224:
2217:
2209:
2202:
2201:
2158:
2128:
2085:
2050:
2004:
1961:
1916:
1914:on 2019-02-25.
1865:
1822:
1787:
1744:
1709:
1707:on 2019-03-08.
1676:(5): E855–62.
1658:
1628:
1626:
1623:
1621:
1620:
1584:
1549:
1500:
1451:
1402:
1361:
1344:
1303:
1285:
1267:
1246:
1224:
1222:
1219:
1209:
1206:
1184:
1181:
1166:
1163:
1133:
1092:
1091:
1088:
1087:
1082:
1072:
1071:
1065:
1064:
1061:
1060:
1058:
1056:
1049:
1048:
1041:
1034:
1030:
1029:
1026:
1025:
1015:
1014:
1008:
1005:
1004:
990:
989:
983:
979:
978:
975:
974:
964:
963:
957:
954:
953:
939:
938:
932:
928:
927:
924:
923:
915:
914:
908:
905:
904:
896:
895:
889:
883:
882:
879:
878:
870:
869:
863:
860:
859:
851:
850:
844:
838:
837:
834:
833:
825:
824:
818:
815:
814:
806:
805:
799:
793:
792:
787:
782:
778:
777:
767:
766:
763:
762:
751:
750:
748:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
691:
689:
685:
684:
682:
681:
676:
671:
665:
663:
659:
658:
656:
655:
650:
645:
640:
635:
630:
625:
620:
614:
612:
608:
607:
597:
596:
593:
592:
589:
588:
580:
579:
561:
555:
554:
551:
550:
542:
541:
538:
537:
535:
534:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
491:
490:
479:
476:
475:
473:
472:
468:
464:
463:jejunal mucosa
460:
456:
452:
448:
447:saphenous vein
444:
440:
436:
432:
429:
428:
416:
415:
407:
396:
390:
389:
386:RNA expression
378:
377:
374:
373:
365:
361:
360:
352:
349:
344:
338:
337:
328:
321:
315:
311:
310:
305:
299:
298:
290:
289:
277:
276:
273:
272:
264:
260:
259:
251:
248:
243:
237:
236:
227:
220:
214:
210:
209:
202:
196:
195:
187:
186:
174:
173:
130:
126:
125:
117:
109:
108:
104:
103:
100:
99:
96:
95:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4492:
4481:
4478:
4476:
4473:
4472:
4470:
4460:
4455:
4450:
4446:
4432:
4428:
4427:
4422:
4419:
4415:
4414:
4409:
4406:
4402:
4401:
4396:
4393:
4389:
4388:
4383:
4380:
4376:
4375:
4370:
4367:
4363:
4362:
4357:
4354:
4350:
4349:
4344:
4343:
4341:
4337:
4331:
4328:
4326:
4323:
4321:
4318:
4316:
4313:
4311:
4308:
4307:
4305:
4301:
4295:
4292:
4290:
4289:Enzyme family
4287:
4285:
4282:
4280:
4277:
4276:
4274:
4270:
4264:
4261:
4259:
4256:
4254:
4253:Cooperativity
4251:
4249:
4246:
4245:
4243:
4239:
4233:
4230:
4228:
4225:
4223:
4220:
4218:
4215:
4213:
4212:Oxyanion hole
4210:
4208:
4205:
4203:
4200:
4198:
4195:
4194:
4192:
4188:
4184:
4177:
4172:
4170:
4165:
4163:
4158:
4157:
4154:
4134:
4131:
4129:
4126:
4124:
4121:
4119:
4116:
4114:
4111:
4109:
4106:
4104:
4101:
4100:
4098:
4096:
4092:
4088:
4083:
4078:
4074:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4040:
4037:
4035:
4032:
4030:
4027:
4023:
4020:
4018:
4015:
4013:
4010:
4008:
4005:
4004:
4003:
4000:
3999:
3997:
3994:
3990:
3983:
3982:
3980:
3977:
3973:
3966:
3965:
3963:
3960:
3956:
3949:
3948:
3946:
3943:
3939:
3933:
3930:
3928:
3925:
3923:
3920:
3919:
3917:
3914:
3910:
3904:
3901:
3899:
3896:
3892:
3889:
3887:
3884:
3882:
3879:
3877:
3874:
3872:
3869:
3867:
3864:
3862:
3859:
3858:
3857:
3854:
3850:
3847:
3845:
3842:
3840:
3837:
3835:
3832:
3831:
3830:
3827:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3805:
3803:
3800:
3798:
3795:
3793:
3790:
3788:
3785:
3784:
3783:
3780:
3779:
3777:
3774:
3770:
3762:
3759:
3757:
3754:
3752:
3749:
3748:
3747:
3744:
3740:
3737:
3735:
3732:
3730:
3727:
3726:
3725:
3722:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3700:
3698:
3695:
3693:
3690:
3688:
3685:
3684:
3683:
3680:
3679:
3677:
3674:
3670:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3620:
3618:
3615:
3611:
3605:
3602:
3600:
3597:
3595:
3592:
3590:
3587:
3585:
3582:
3580:
3577:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3555:
3552:
3550:
3547:
3545:
3542:
3540:
3537:
3535:
3532:
3530:
3527:
3525:
3522:
3520:
3517:
3515:
3512:
3511:
3509:
3506:
3502:
3496:
3493:
3491:
3488:
3486:
3483:
3481:
3478:
3477:
3475:
3472:
3468:
3464:
3459:
3454:
3450:
3436:
3433:
3431:
3428:
3426:
3423:
3421:
3418:
3417:
3415:
3412:
3408:
3402:
3399:
3397:
3394:
3393:
3391:
3388:
3384:
3378:
3375:
3373:
3370:
3368:
3365:
3363:
3360:
3358:
3355:
3354:
3352:
3349:
3345:
3339:
3336:
3334:
3331:
3329:
3326:
3324:
3321:
3320:
3318:
3315:
3311:
3305:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3275:
3272:
3270:
3267:
3265:
3262:
3260:
3257:
3255:
3252:
3250:
3247:
3245:
3242:
3240:
3237:
3235:
3232:
3230:
3227:
3225:
3222:
3220:
3217:
3215:
3212:
3210:
3207:
3205:
3202:
3200:
3197:
3195:
3192:
3190:
3187:
3185:
3182:
3180:
3177:
3175:
3172:
3170:
3167:
3165:
3162:
3160:
3157:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3085:
3082:
3080:
3077:
3075:
3072:
3070:
3067:
3065:
3062:
3060:
3057:
3055:
3052:
3050:
3047:
3045:
3042:
3040:
3037:
3035:
3032:
3030:
3027:
3026:
3024:
3021:
3017:
3011:
3008:
3006:
3003:
3001:
2998:
2997:
2995:
2992:
2988:
2982:
2979:
2977:
2974:
2973:
2971:
2968:
2964:
2958:
2955:
2954:
2952:
2949:
2945:
2939:
2936:
2934:
2931:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2911:
2909:
2906:
2904:
2901:
2899:
2896:
2894:
2891:
2889:
2886:
2884:
2881:
2879:
2876:
2875:
2873:
2870:
2866:
2860:
2857:
2855:
2852:
2851:
2849:
2846:
2842:
2836:
2833:
2831:
2828:
2826:
2823:
2821:
2818:
2816:
2813:
2812:
2810:
2807:
2803:
2797:
2794:
2792:
2789:
2787:
2784:
2782:
2779:
2777:
2774:
2772:
2769:
2768:
2766:
2763:
2759:
2752:
2751:
2749:
2747:(EC 2.7.11.9)
2746:
2742:
2736:
2733:
2731:
2728:
2727:
2725:
2723:(EC 2.7.11.8)
2722:
2718:
2710:
2707:
2705:
2702:
2700:
2697:
2696:
2695:
2694:Aurora kinase
2692:
2691:
2689:
2687:(EC 2.7.11.7)
2686:
2682:
2676:
2673:
2672:
2670:
2668:(EC 2.7.11.6)
2667:
2663:
2657:
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2638:
2636:
2634:(EC 2.7.11.5)
2633:
2629:
2623:
2620:
2618:
2615:
2613:
2610:
2609:
2607:
2605:(EC 2.7.11.4)
2604:
2600:
2592:
2589:
2587:
2584:
2582:
2579:
2578:
2576:
2572:
2569:
2567:
2564:
2563:
2561:
2557:
2554:
2552:
2549:
2548:
2546:
2543:
2542:
2540:
2538:(EC 2.7.11.3)
2537:
2533:
2527:
2524:
2522:
2519:
2517:
2514:
2512:
2509:
2508:
2506:
2504:(EC 2.7.11.2)
2503:
2499:
2491:
2488:
2487:
2486:
2483:
2479:
2476:
2474:
2471:
2469:
2466:
2464:
2461:
2460:
2459:
2458:EIF-2 kinases
2456:
2454:
2451:
2449:
2446:
2442:
2439:
2437:
2434:
2432:
2429:
2428:
2427:
2424:
2422:
2419:
2417:
2414:
2412:
2409:
2407:
2404:
2402:
2399:
2397:
2394:
2392:
2389:
2387:
2384:
2382:
2379:
2377:
2374:
2372:
2369:
2368:
2366:
2364:(EC 2.7.11.1)
2363:
2359:
2355:
2350:
2345:
2341:
2336:
2332:
2328:
2321:
2316:
2314:
2309:
2307:
2302:
2301:
2298:
2284:
2278:
2273:
2269:
2263:
2258:
2254:
2248:
2243:
2239:
2230:
2225:
2223:
2218:
2216:
2211:
2210:
2207:
2198:
2194:
2189:
2184:
2180:
2176:
2172:
2168:
2164:
2159:
2155:
2151:
2147:
2143:
2140:(2): 341–55.
2139:
2135:
2129:
2125:
2121:
2116:
2111:
2107:
2103:
2100:(3): 407–16.
2099:
2095:
2091:
2086:
2082:
2078:
2073:
2068:
2064:
2060:
2056:
2051:
2047:
2043:
2039:
2035:
2031:
2027:
2023:
2019:
2015:
2011:
2005:
2001:
1997:
1992:
1987:
1983:
1979:
1975:
1971:
1967:
1962:
1958:
1954:
1949:
1944:
1939:
1934:
1930:
1926:
1922:
1917:
1910:
1906:
1902:
1898:
1894:
1890:
1886:
1882:
1878:
1871:
1866:
1862:
1858:
1853:
1848:
1844:
1840:
1836:
1832:
1828:
1823:
1819:
1815:
1810:
1805:
1801:
1797:
1793:
1788:
1784:
1780:
1775:
1770:
1766:
1762:
1758:
1754:
1750:
1745:
1741:
1737:
1732:
1727:
1723:
1719:
1715:
1710:
1703:
1699:
1695:
1691:
1687:
1683:
1679:
1675:
1671:
1664:
1659:
1655:
1651:
1647:
1643:
1640:(2): 151–65.
1639:
1635:
1630:
1629:
1624:
1616:
1612:
1608:
1604:
1601:(2): 341–55.
1600:
1596:
1588:
1585:
1580:
1576:
1572:
1568:
1565:(2): 151–65.
1564:
1560:
1553:
1550:
1545:
1541:
1536:
1531:
1527:
1523:
1519:
1515:
1511:
1504:
1501:
1496:
1492:
1487:
1482:
1478:
1474:
1471:(3): 407–16.
1470:
1466:
1462:
1455:
1452:
1447:
1443:
1438:
1433:
1429:
1425:
1421:
1417:
1413:
1406:
1403:
1398:
1394:
1389:
1384:
1380:
1376:
1372:
1365:
1362:
1357:
1351:
1349:
1345:
1340:
1336:
1331:
1326:
1322:
1318:
1314:
1307:
1304:
1299:
1295:
1289:
1286:
1281:
1277:
1271:
1268:
1264:
1260:
1255:
1253:
1251:
1247:
1243:
1239:
1234:
1232:
1230:
1226:
1220:
1218:
1216:
1207:
1205:
1203:
1199:
1195:
1191:
1182:
1180:
1178:
1173:
1164:
1162:
1160:
1156:
1152:
1148:
1144:
1140:
1136:
1129:
1125:
1121:
1117:
1113:
1110:
1106:
1102:
1100:
1086:
1081:
1077:
1073:
1070:
1066:
1059:
1057:
1054:
1050:
1046:
1042:
1039:
1035:
1031:
1024:
1022:
1016:
1012:
1009:
1003:
1001:
997:
991:
987:
984:
980:
973:
971:
965:
961:
958:
952:
950:
946:
940:
936:
933:
931:RefSeq (mRNA)
929:
922:
921:
916:
912:
909:
903:
902:
897:
893:
890:
888:
884:
877:
876:
871:
867:
864:
858:
857:
852:
848:
845:
843:
839:
832:
831:
826:
822:
819:
813:
812:
807:
803:
800:
798:
794:
791:
788:
786:
783:
779:
776:
772:
768:
761:
757:
752:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
692:
690:
687:
686:
680:
679:mitochondrion
677:
675:
672:
670:
667:
666:
664:
661:
660:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
615:
613:
610:
609:
606:
605:Gene ontology
602:
598:
586:
581:
577:
570:
565:
562:
560:
556:
548:
543:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
495:
492:
488:
483:
480:
471:parotid gland
470:
466:
462:
458:
455:skin of thigh
454:
450:
446:
442:
438:
434:
433:
430:
426:
421:
418:
417:
414:
412:
408:
406:
405:
401:
400:
397:
395:
391:
387:
383:
379:
371:
366:
362:
358:
353:
343:
339:
332:
325:
319:
312:
304:
300:
296:
291:
287:
282:
278:
270:
265:
261:
257:
252:
242:
238:
231:
224:
218:
211:
207:
201:
197:
193:
188:
184:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
127:
122:
115:
110:
105:
94:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
4426:Translocases
4423:
4410:
4397:
4384:
4371:
4361:Transferases
4358:
4345:
4202:Binding site
3633:P70S6 kinase
2520:
2282:
2267:
2252:
2170:
2166:
2137:
2133:
2097:
2093:
2062:
2058:
2013:
2009:
1973:
1969:
1928:
1925:PLOS Biology
1924:
1909:the original
1880:
1876:
1834:
1830:
1799:
1795:
1756:
1752:
1721:
1717:
1702:the original
1673:
1669:
1637:
1633:
1598:
1594:
1587:
1562:
1558:
1552:
1517:
1513:
1503:
1468:
1464:
1454:
1419:
1415:
1405:
1378:
1374:
1364:
1320:
1316:
1306:
1297:
1288:
1279:
1270:
1211:
1200:, PDK3, and
1186:
1168:
1108:
1096:
1095:
1018:
996:NP_001135858
993:
967:
949:NM_001142386
942:
918:
899:
873:
854:
828:
809:
789:
784:
501:right kidney
409:
402:
129:External IDs
72:
4197:Active site
4084:(EC 2.7.12)
3471:Polo kinase
3411:Polo kinase
2235:PDB gallery
1931:(9): E247.
1177:alpha helix
648:ATP binding
529:granulocyte
368:92,875,807
355:92,808,213
347:X|X C3
267:24,550,466
254:24,465,244
107:Identifiers
4469:Categories
4400:Isomerases
4374:Hydrolases
4241:Regulation
2762:IÎşB kinase
2337:2.7.11-12)
1265:, May 2017
1244:, May 2017
1221:References
1208:Regulation
1172:C-terminal
1139:glycolysis
1128:acetyl-CoA
413:(ortholog)
150:HomoloGene
4480:EC 2.7.11
4279:EC number
2888:PKC alpha
2167:Structure
1165:Structure
1099:lipoamide
1021:NP_663605
1000:NP_005382
970:NM_145630
945:NM_005391
775:Orthologs
674:nucleolus
497:spermatid
158:GeneCards
4303:Kinetics
4227:Cofactor
4190:Activity
3244:KIAA0999
3139:MAPKAPK5
3134:MAPKAPK3
3129:MAPKAPK2
2197:17683942
2154:17669420
2124:17532006
2081:16849321
2038:16189514
2000:15861126
1957:15226823
1905:13601849
1897:14966024
1861:11978179
1818:11486000
1783:11485553
1740:10748134
1698:12494500
1690:12676647
1654:12476789
1615:17669420
1579:12476789
1544:11485553
1495:17532006
1446:15861126
1397:16849321
1261:–
1240:–
1190:isozymes
1183:Function
1159:isoforms
1141:and the
1124:pyruvate
1069:Wikidata
754:Sources:
525:epiblast
4459:Biology
4413:Ligases
4183:Enzymes
3903:MAP3K14
3881:MAP3K11
3876:MAP3K10
3866:MAP3K13
3861:MAP3K12
3663:RPS6KC1
3658:RPS6KA1
3653:RPS6KA3
3648:RPS6KA2
3643:RPS6KB2
3628:RPS6KA4
3623:RPS6KA5
3274:Kalirin
3239:SNF1LK2
2478:EIF2AK4
2473:EIF2AK3
2327:Kinases
2188:2871385
2115:1994203
2046:4427026
2018:Bibcode
1991:1142596
1852:1222743
1774:1222033
1535:1222033
1486:1994203
1437:1142596
1339:7499431
1263:Ensembl
1242:Ensembl
1116:isozyme
887:UniProt
842:Ensembl
781:Species
760:QuickGO
388:pattern
246:Xp22.11
146:2384308
114:Aliases
4445:Portal
4387:Lyases
4133:MAP2K7
4128:MAP2K6
4123:MAP2K5
4118:MAP2K4
4113:MAP2K3
4108:MAP2K2
4103:MAP2K1
4054:ACVRL1
4049:ACVR2B
4044:ACVR2A
4039:ACVR1C
4034:ACVR1B
4017:BMPR1B
4012:BMPR1A
3886:MAP3K7
3871:MAP3K9
3822:MAP3K8
3817:MAP3K7
3812:MAP3K6
3807:MAP3K5
3802:MAP3K4
3797:MAP3K3
3792:MAP3K2
3787:MAP3K1
3761:MAPK14
3756:MAPK13
3751:MAPK11
3739:MAPK10
3717:MAPK15
3712:MAPK12
3604:CDC2L1
3579:CDC2L5
3254:SNF1LK
3079:CAMK2G
3074:CAMK2D
3069:CAMK2B
3064:CAMK2A
3054:CAMK1G
3049:CAMK1D
3044:CAMK1B
3039:CAMK1A
2893:PRKCB1
2830:PRKACA
2825:PRKACB
2820:PRKACG
2796:IKBKAP
2622:BCKDHB
2617:BCKDHA
2591:PRKAG3
2586:PRKAG2
2581:PRKAG1
2571:PRKAB2
2566:PRKAB1
2556:PRKAA2
2551:PRKAA1
2396:STK38L
2195:
2185:
2152:
2122:
2112:
2079:
2044:
2036:
2010:Nature
1998:
1988:
1955:
1948:439783
1945:
1903:
1895:
1859:
1849:
1816:
1781:
1771:
1738:
1696:
1688:
1652:
1613:
1577:
1542:
1532:
1493:
1483:
1444:
1434:
1395:
1337:
1105:enzyme
1103:is an
1055:search
1053:PubMed
920:Q922H2
901:Q15120
830:236900
797:Entrez
559:BioGPS
138:300906
4339:Types
4095:MAP2K
4029:ACVR1
4022:BMPR2
4007:BMPR1
3932:GSK-3
3773:MAP3K
3734:MAPK9
3729:MAPK8
3707:MAPK7
3702:MAPK6
3697:MAPK4
3692:MAPK3
3687:MAPK1
3599:PFTK1
3594:PCTK3
3589:PCTK2
3584:PCTK1
3574:CDK12
3569:CDK10
3544:CDKL5
3524:CDKL2
3401:STK19
3396:EEF2K
3377:PHKG2
3372:PHKG1
3362:PHKA2
3357:PHKA1
3338:MYLK4
3333:MYLK3
3328:MYLK2
3304:DCLK1
3299:Titin
3289:TRIB3
3284:TRIB2
3279:TRIB1
3269:TSSK2
3249:STK40
3234:PSKH1
3229:PRKD3
3224:PRKD2
3204:PHKG2
3199:PHKG1
3189:OBSCN
3184:NUAK2
3179:NUAK1
3174:MKNK2
3169:MKNK1
3159:MARK4
3154:MARK3
3149:MARK2
3144:MARK1
3124:STK11
3119:DAPK3
3114:DAPK2
3109:DAPK1
3104:CHEK2
3099:CHEK1
3084:CAMK4
3059:CAMK2
3034:CAMK1
3029:BRSK2
2923:PRKCQ
2918:PRKCI
2913:PRKCG
2908:PRKCH
2903:PRKCE
2898:PRKCD
2859:PRKG1
2791:IKBKG
2786:IKBKE
2735:STK10
2730:FASTK
2656:IDH3G
2651:IDH3B
2646:IDH3A
2612:BCKDK
2406:ROCK1
2391:STK38
2386:MAST2
2381:MAST1
2376:LATS2
2371:LATS1
2042:S2CID
1912:(PDF)
1901:S2CID
1873:(PDF)
1705:(PDF)
1694:S2CID
1666:(PDF)
790:Mouse
785:Human
756:Amigo
517:molar
411:Mouse
404:Human
351:Start
286:Mouse
250:Start
183:Human
154:55897
4431:list
4424:EC7
4418:list
4411:EC6
4405:list
4398:EC5
4392:list
4385:EC4
4379:list
4372:EC3
4366:list
4359:EC2
4353:list
4346:EC1
3922:TPK1
3898:CDC7
3856:MLKs
3849:KSR2
3844:KSR1
3839:BRAF
3834:ARAF
3829:RAFs
3564:CDK9
3559:CDK8
3554:CDK7
3549:CDK6
3539:CDK5
3534:CDK4
3529:CDK3
3519:CDK2
3514:CDK1
3495:PLK4
3490:PLK3
3485:PLK2
3480:PLK1
3435:PLK4
3430:PLK3
3425:PLK2
3420:PLK1
3367:PHKB
3323:MYLK
3294:TRIO
3264:SPEG
3259:SNRK
3219:PKD1
3214:PIM2
3209:PIM1
3194:PASK
3164:MELK
3094:CASK
3089:MLCK
3010:GRK6
3005:GRK5
3000:GRK4
2938:PKN3
2933:PKN2
2835:PRKY
2781:TBK1
2776:IKK2
2771:CHUK
2675:STK4
2641:IDH2
2526:PDK4
2521:PDK3
2516:PDK2
2511:PDK1
2490:WEE1
2485:Wee1
2453:mTOR
2441:AKT3
2436:AKT2
2431:AKT1
2421:SGK3
2416:SGK2
2283:1y8p
2268:1y8o
2253:1y8n
2193:PMID
2150:PMID
2120:PMID
2077:PMID
2034:PMID
1996:PMID
1953:PMID
1893:PMID
1857:PMID
1814:PMID
1779:PMID
1736:PMID
1686:PMID
1650:PMID
1611:PMID
1575:PMID
1540:PMID
1491:PMID
1442:PMID
1393:PMID
1335:PMID
1202:PDK4
1198:PDK2
1194:PDK1
1130:and
1112:gene
1109:PDK3
811:5165
394:Bgee
342:Band
303:Chr.
241:Band
200:Chr.
162:PDK3
134:OMIM
121:PDK3
91:2Q8I
87:2PNR
83:1Y8P
79:1Y8O
75:1Y8N
56:RCSB
53:PDBe
22:PDK3
3927:TTK
3891:ZAK
2468:HRI
2463:PKR
2411:SGK
2401:CIT
2183:PMC
2175:doi
2142:doi
2138:372
2110:PMC
2102:doi
2098:370
2067:doi
2063:281
2026:doi
2014:437
1986:PMC
1978:doi
1943:PMC
1933:doi
1885:doi
1847:PMC
1839:doi
1835:366
1804:doi
1800:276
1769:PMC
1761:doi
1757:358
1726:doi
1722:275
1678:doi
1674:284
1642:doi
1603:doi
1599:372
1567:doi
1530:PMC
1522:doi
1518:358
1481:PMC
1473:doi
1469:370
1432:PMC
1424:doi
1383:doi
1379:281
1325:doi
1321:270
1126:to
1118:of
364:End
263:End
166:OMA
142:MGI
46:PDB
4471::
2577:Îł
2562:β
2547:α
2335:EC
2329::
2191:.
2181:.
2171:15
2169:.
2165:.
2148:.
2136:.
2118:.
2108:.
2096:.
2092:.
2075:.
2061:.
2057:.
2040:.
2032:.
2024:.
2012:.
1994:.
1984:.
1974:24
1972:.
1968:.
1951:.
1941:.
1927:.
1923:.
1899:.
1891:.
1881:96
1879:.
1875:.
1855:.
1845:.
1833:.
1829:.
1812:.
1798:.
1794:.
1777:.
1767:.
1755:.
1751:.
1734:.
1720:.
1716:.
1692:.
1684:.
1672:.
1668:.
1648:.
1636:.
1609:.
1597:.
1573:.
1561:.
1538:.
1528:.
1516:.
1512:.
1489:.
1479:.
1467:.
1463:.
1440:.
1430:.
1420:24
1418:.
1414:.
1391:.
1377:.
1373:.
1347:^
1333:.
1319:.
1315:.
1296:.
1278:.
1249:^
1228:^
1196:,
1132:CO
758:/
370:bp
357:bp
269:bp
256:bp
164:;
160::
156:;
152::
148:;
144::
140:;
136::
89:,
85:,
81:,
77:,
4447::
4433:)
4429:(
4420:)
4416:(
4407:)
4403:(
4394:)
4390:(
4381:)
4377:(
4368:)
4364:(
4355:)
4351:(
4175:e
4168:t
4161:v
3984:-
3967:-
3950:-
2753:-
2333:(
2319:e
2312:t
2305:v
2228:e
2221:t
2214:v
2199:.
2177::
2156:.
2144::
2126:.
2104::
2083:.
2069::
2048:.
2028::
2020::
2002:.
1980::
1959:.
1935::
1929:2
1887::
1863:.
1841::
1820:.
1806::
1785:.
1763::
1742:.
1728::
1680::
1656:.
1644::
1638:2
1617:.
1605::
1581:.
1569::
1563:2
1546:.
1524::
1497:.
1475::
1448:.
1426::
1399:.
1385::
1358:.
1341:.
1327::
1300:.
1282:.
1213:(
1134:2
288:)
185:)
168::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
