562:
539:
2869:
436:
461:
3584:
3554:
3539:
3419:
3434:
820:
3464:
3569:
3449:
3524:
3509:
3494:
3479:
813:
568:
467:
49:
3599:
1782:, require the binding at this docking site. Small molecule allosteric activators of PDPK1 were shown to selectively inhibit activation of substrates that require docking site interaction. These compounds do not bind to the active site and allow PDPK1 to activate other substrates that do not require docking site interaction. PDPK1 is constitutively active and at present, there is no known inhibitor proteins for PDPK1.
5776:
2948:
Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT (1998). "Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B".
75:
1658:
Plant PDK1 plays an important role in regulating PIN-mediated auxin transport, and is thus involved in various developmental processes, such as embryonic development, lateral root formation, vasculature patterning, apical hook formation, gravitropism and phototropism.
2457:
Chun J, Kwon T, Lee E, Suh PG, Choi EJ, Sun Kang S (October 2002). "The Na(+)/H(+) exchanger regulatory factor 2 mediates phosphorylation of serum- and glucocorticoid-induced protein kinase 1 by 3-phosphoinositide-dependent protein kinase 1".
3639:
3924:
3583:
3553:
3146:"Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2"
3538:
1648:
Mice lacking PDPK1 die during early embryonic development, indicating that this enzyme is critical for transmitting the growth-promoting signals necessary for normal mammalian development.
2419:
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ (September 1998). "Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1".
3632:
2988:"Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha"
3076:
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ (1998). "Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1".
2279:"A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1"
3625:
3832:
2751:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
2191:"Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343"
575:
474:
33:
3322:"Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo"
1850:
1651:
Mice that are deficient in PDPK1 have a ≈40% decrease in body mass, mild glucose intolerance, and are resistant to cancer brought about by hyperactivation of the
1743:. PDPK1 however does not require membrane lipid binding for the efficient phosphorylation of most of its substrates in the cytosol (not at the cell membrane).
4380:
5219:
3683:
3418:
2878:"Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK"
1778:
binding sites; the substrate binding site, the ATP binding site, and the docking site (also known as PIF pocket). Several PDPK1 substrates including S6K and
3433:
5328:
4066:
3953:
1785:
The activation of PDPK1's main effector, AKT, is believed to require a proper orientation of the kinase and PH domains of PDPK1 and AKT at the membrane.
1764:
1726:
1710:
1288:
397:
4341:
3463:
1269:
3568:
3448:
5314:
4779:
3670:
3652:
3523:
3508:
3493:
3478:
5416:
5297:
1760:
1722:
1706:
2700:
Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M (1997).
5003:
3872:
3107:"Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1"
2235:
Hodgkinson CP, Sale GJ (January 2002). "Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment".
5796:
5067:
4042:
3398:
1936:
1918:
5323:
2911:
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G (1998). "Phosphorylation and activation of p70s6k by PDK1".
2577:
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
1970:"Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma"
561:
3857:
5380:
5055:
3598:
1527:
538:
5495:
4312:
4302:
3987:
1520:
3279:"A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans"
4994:
1954:
5263:
4935:
4297:
4288:
1905:
1884:
2702:"3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase"
460:
435:
5651:
2608:"Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha"
1901:
2054:"A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation"
2017:
Mora A, Komander D, van Aalten DM, Alessi DR (April 2004). "PDK1, the master regulator of AGC kinase signal transduction".
72:
4678:
4175:
4166:
3823:
3769:
2817:"3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro"
1968:
Scortegagna M, Ruller C, Feng Y, Lazova R, Kluger H, Li JL, De SK, Rickert R, Pellecchia M, Bosenberg M, Ronai ZA (2014).
5766:
1880:
3866:
3592:: Crystal Structure Of N1-phenyl]amino]-4-pyrimidinyl]amino]propyl]-2,2-dimethylpropanediamide Complexed with Human PDK1
3562:: CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO DIC4-PHOSPHATIDYLINOSITOL (3,4,5)-TRISPHOSPHATE
377:
3366:
1794:
1641:. An important role for PDPK1 is in the signaling pathways activated by several growth factors and hormones including
574:
473:
3617:
4890:
4708:
4204:
5636:
567:
466:
368:, PDK1, PDPK2, PRO0461, PDPK2P, Phosphoinositide-dependent kinase-1, 3-phosphoinositide dependent protein kinase 1
5752:
5739:
5726:
5713:
5700:
5687:
5674:
4880:
4875:
4870:
4860:
4855:
4850:
4840:
4635:
4410:
4006:
3391:
2320:"Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA"
5646:
5801:
5600:
5543:
5103:
5094:
5045:
3811:
3656:
3370:
3185:"PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2"
1333:
385:
1767:
which is important in localization and activation of some of membrane associated PDPK1's substrates including
3547:: CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO INOSITOL (1,3,4,5)-TETRAKISPHOSPHATE
3236:"Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway"
2372:"Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway"
5548:
5403:
4826:
1314:
3027:"Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B"
2868:
2189:
Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S (July 2001).
2101:
Tan S, Zhang X, Kong W, Yang XL, Molnár G, Vondráková Z, Filepová R, Petrášek J, Friml J, Xue HW (2020).
5569:
5488:
4102:
1736:
1730:
1718:
1702:
1652:
449:
5641:
4669:
3384:
3196:
3038:
2958:
2920:
2831:
2713:
2619:
2495:"Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3"
2103:"The lipid code-dependent phosphoswitch PDK1–D6PK activates PIN-mediated auxin efflux in Arabidopsis"
1832:
2816:
2657:
Moser BA, Dennis PB, Pullen N, Pearson RB, Williamson NA, Wettenhall RE, Kozma SC, Thomas G (1997).
364:
5605:
3105:
Currie RA, Walker KS, Gray A, Deak M, Casamayor A, Downes CP, Cohen P, Alessi DR, Lucocq J (1999).
1499:
1495:
1466:
1436:
1432:
1403:
5177:
5806:
5538:
5280:
5234:
3222:
3064:
2857:
2739:
2645:
2130:
409:
3183:
Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes CP, Alessi DR (1999).
1626:
1503:
1474:
1470:
1440:
1411:
1407:
1751:
The structure of PDPK1 can be divided into two domains; the kinase or catalytic domain and the
4540:
4249:
3347:
3308:
3265:
3214:
3171:
3132:
3093:
3056:
3013:
2974:
2936:
2899:
2849:
2803:
2768:
2731:
2688:
2637:
2594:
2565:
2516:
2475:
2436:
2401:
2349:
2300:
2252:
2212:
2171:
2122:
2083:
2034:
1999:
1838:
357:
65:
5584:
5579:
5553:
5481:
5133:
4375:
4365:
4360:
4278:
4269:
4199:
4190:
4136:
4127:
3784:
3337:
3329:
3298:
3290:
3255:
3247:
3204:
3161:
3153:
3122:
3114:
3085:
3046:
3003:
2995:
2966:
2928:
2889:
2839:
2793:
2760:
2721:
2678:
2670:
2627:
2586:
2555:
2547:
2506:
2467:
2428:
2391:
2383:
2339:
2331:
2290:
2244:
2202:
2161:
2114:
2073:
2065:
2026:
1989:
1981:
1779:
1630:
654:
585:
529:
484:
2052:
Frödin M, Antal TL, Dümmler BA, Jensen CJ, Deak M, Gammeltoft S, Biondi RM (October 2002).
819:
405:
5631:
5615:
5528:
4959:
4030:
4025:
4020:
2782:"Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta"
812:
629:
3200:
3042:
2962:
2924:
2835:
2717:
2623:
5780:
5669:
5610:
3342:
3321:
3260:
3235:
3166:
3145:
3127:
3106:
3008:
2987:
2560:
2539:
2396:
2371:
1994:
1969:
48:
3303:
3278:
3209:
3184:
3051:
3026:
2844:
2764:
2726:
2701:
2683:
2658:
2632:
2607:
2471:
2344:
2319:
2078:
2053:
1203:
1198:
1193:
1188:
1183:
1178:
1173:
1168:
1163:
1158:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
987:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
5790:
5574:
5533:
4083:
4015:
2590:
2150:"Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI"
2134:
1729:. However, PDPK1 is believed to be constitutively active and does not always require
848:
3226:
3068:
2861:
2102:
389:
5523:
4954:
3779:
2743:
2649:
1580:
647:
426:
3089:
2432:
1739:
are only required for the activation at the membrane of some substrates including
2970:
2932:
2606:
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P (1997).
2030:
1044:
negative regulation of transforming growth factor beta receptor signaling pathway
413:
5747:
5682:
5518:
5160:
4792:
4732:
4615:
4535:
4259:
3333:
3157:
3118:
2551:
1941:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1923:
National Center for
Biotechnology Information, U.S. National Library of Medicine
5775:
3251:
2387:
2277:
Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR (July 2000).
730:
5248:
3722:
2318:
Biondi RM, Cheung PC, Casamayor A, Deak M, Currie RA, Alessi DR (March 2000).
2118:
546:
443:
393:
2798:
2781:
2335:
5721:
5695:
4209:
2370:
Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA (June 1999).
1756:
1752:
1233:
790:
668:
613:
600:
512:
499:
401:
3351:
3312:
3294:
3269:
3218:
3175:
2894:
2877:
2569:
2520:
2511:
2494:
2479:
2405:
2353:
2304:
2295:
2278:
2256:
2216:
2207:
2190:
2175:
2166:
2149:
2126:
2087:
2069:
2038:
2003:
3136:
3097:
3060:
3017:
2978:
2940:
2903:
2853:
2807:
2772:
2735:
2692:
2674:
2641:
2598:
2440:
1567:
1562:
4565:
4460:
4455:
4450:
1985:
1606:
1551:
1378:
1359:
2659:"Dual requirement for a newly identified phosphorylation site in p70s6k"
5224:
5202:
5197:
5187:
5182:
4984:
4979:
4974:
4969:
4964:
4949:
4944:
4595:
4560:
3799:
3794:
3789:
3234:
Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA (1999).
1642:
1588:
1345:
1300:
3427:: HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN PDK1 CATALYTIC DOMAIN
2999:
2248:
1039:
positive regulation of release of sequestered calcium ion into cytosol
334:
330:
326:
322:
318:
314:
310:
306:
302:
298:
294:
290:
286:
282:
278:
274:
270:
266:
262:
258:
254:
250:
246:
242:
238:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
5734:
5504:
5454:
5449:
5444:
5439:
5434:
5429:
5424:
5375:
5370:
5365:
5360:
5355:
5338:
5333:
5207:
5192:
5143:
5138:
5123:
5118:
5113:
5108:
5082:
5077:
5072:
5060:
5038:
5033:
4925:
4900:
4575:
4400:
4395:
4390:
4385:
4370:
4214:
4151:
4146:
4141:
4117:
3943:
3938:
3912:
3907:
3902:
3892:
3887:
3877:
3717:
3648:
3442:: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE
1814:
1775:
1618:
1595:
1535:
1255:
17:
2986:
Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR (1998).
5708:
5350:
5343:
5253:
5150:
5050:
5028:
5023:
5018:
5013:
5008:
4920:
4915:
4910:
4905:
4895:
4865:
4845:
4722:
4717:
4698:
4693:
4683:
4659:
4654:
4649:
4625:
4620:
4610:
4605:
4600:
4590:
4570:
4555:
4550:
4545:
4525:
4520:
4510:
4505:
4500:
4495:
4490:
4480:
4475:
4470:
4465:
4445:
4440:
4435:
4430:
4425:
4420:
4405:
4355:
4350:
4244:
4239:
4234:
4229:
4224:
4219:
4180:
4112:
4107:
4056:
4051:
3977:
3972:
3967:
3933:
3925:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
3727:
3712:
3707:
3702:
3697:
3692:
1856:
1826:
1820:
1701:
through PDPK1's interaction with membrane phospholipids including
1605:
in humans. It is implicated in the development and progression of
1218:
1214:
5243:
5170:
5165:
5155:
5128:
4885:
4835:
4816:
4811:
4806:
4801:
4756:
4751:
4746:
4741:
4688:
4644:
4585:
4580:
4530:
4515:
4485:
4415:
4331:
4326:
4321:
4254:
4156:
4097:
4092:
3996:
3962:
3847:
3842:
3837:
3806:
3774:
3762:
3757:
3752:
3742:
3737:
3472:: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH LY333531
1808:
1802:
1714:
1698:
1602:
381:
5477:
5401:
4777:
3668:
3621:
3577:: CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN
3380:
2780:
Meier R, Alessi DR, Cron P, Andjelković M, Hemmings BA (1997).
1164:
cellular response to brain-derived neurotrophic factor stimulus
828:
5212:
3747:
3732:
3457:: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH UCN-01
3376:
2815:
Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J (1998).
1844:
1768:
1740:
1638:
1634:
1622:
1194:
positive regulation of vascular endothelial cell proliferation
1184:
positive regulation of blood vessel endothelial cell migration
1174:
positive regulation of protein localization to plasma membrane
3532:: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-8
3517:: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-3
3502:: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-1
3487:: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-2
2876:
Dalby KN, Morrice N, Caudwell FB, Avruch J, Cohen P (1998).
1084:
negative regulation of cardiac muscle cell apoptotic process
1094:
negative regulation of toll-like receptor signaling pathway
5473:
3277:
Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G (1999).
3025:
Anderson KE, Coadwell J, Stephens LR, Hawkins PT (1998).
1204:
negative regulation of endothelial cell apoptotic process
2540:"The PI3K-PDK1 connection: more than just a road to PKB"
637:
1793:
Phosphoinositide-dependent kinase-1 has been shown to
5764:
1064:
cellular response to epidermal growth factor stimulus
802:
1034:
stimulatory C-type lectin receptor signaling pathway
887:
3-phosphoinositide-dependent protein kinase activity
5660:
5624:
5593:
5562:
5511:
5415:
5313:
5296:
5279:
5262:
5233:
5093:
4993:
4934:
4825:
4791:
4731:
4707:
4668:
4634:
4340:
4311:
4287:
4268:
4189:
4165:
4126:
4082:
4065:
4041:
4005:
3986:
3952:
3923:
3856:
3822:
3682:
1488:
1459:
1425:
1396:
1897:
1895:
1893:
1876:
1874:
1872:
1759:functions mainly in the interaction of PDPK1 with
1169:epidermal growth factor receptor signaling pathway
1149:regulation of I-kappaB kinase/NF-kappaB signaling
584:
483:
34:Pyruvate dehydrogenase lipoamide kinase isozyme 1
2452:
2450:
2365:
2363:
2272:
2270:
2268:
2266:
2230:
2228:
2226:
1159:negative regulation of neuron apoptotic process
27:Protein-coding gene in the species Homo sapiens
3607:: STRUCTURE OF PDK1-S241A MUTANT KINASE DOMAIN
1902:GRCm38: Ensembl release 89: ENSMUSG00000024122
1717:indirectly regulates PDPK1 by phosphorylating
1019:negative regulation of protein kinase activity
5489:
3684:Non-specific serine/threonine protein kinases
3633:
3392:
1592:3-phosphoinositide-dependent protein kinase-1
1199:positive regulation of sprouting angiogenesis
1074:positive regulation of phospholipase activity
8:
3367:3-phosphoinositide-dependent+protein+kinase
3320:Casamayor A, Morrice NA, Alessi DR (1999).
2493:Sato S, Fujita N, Tsuruo T (October 2002).
1881:GRCh38: Ensembl release 89: ENSG00000140992
5496:
5482:
5474:
5412:
5398:
4788:
4774:
4067:Goodpasture-antigen-binding protein kinase
3679:
3665:
3640:
3626:
3618:
3399:
3385:
3377:
1765:phosphatidylinositol (3,4,5)-trisphosphate
1727:phosphatidylinositol (3,4,5)-trisphosphate
1711:phosphatidylinositol (3,4,5)-trisphosphate
1229:
1009:regulation of transcription, DNA-templated
844:
625:
524:
421:
83:
4780:Serine/threonine-specific protein kinases
3954:(isocitrate dehydrogenase (NADP+)) kinase
3671:Serine/threonine-specific protein kinases
3653:Serine/threonine-specific protein kinases
3369:at the U.S. National Library of Medicine
3341:
3302:
3259:
3208:
3165:
3126:
3050:
3007:
2893:
2843:
2797:
2725:
2682:
2631:
2559:
2510:
2395:
2343:
2294:
2206:
2165:
2077:
1993:
1621:, which is crucial for the activation of
5315:Receptor protein serine/threonine kinase
1104:regulation of endothelial cell migration
892:protein serine/threonine kinase activity
5771:
5298:Low-density-lipoprotein receptor kinase
3414:
1868:
1761:phosphatidylinositol (3,4)-bisphosphate
1723:phosphatidylinositol (3,4)-bisphosphate
1707:phosphatidylinositol (3,4)-bisphosphate
1179:activation of protein kinase B activity
38:
4043:Fas-activated serine/threonine kinase
1119:regulation of mast cell degranulation
1109:cellular response to insulin stimulus
1069:Fc-epsilon receptor signaling pathway
1014:extrinsic apoptotic signaling pathway
589:
550:
545:
488:
447:
442:
7:
5324:Bone morphogenetic protein receptors
2538:Vanhaesebroeck B, Alessi DR (2000).
3858:Dephospho-(reductase kinase) kinase
2148:Barry FA, Gibbins JM (April 2002).
1189:positive regulation of angiogenesis
4313:G-protein coupled receptor kinases
1485:
1456:
1422:
1393:
1369:
1350:
1324:
1305:
1279:
1260:
1129:type B pancreatic cell development
1124:peptidyl-threonine phosphorylation
807:
725:
663:
642:
25:
4303:Beta adrenergic receptor kinase-2
3988:(tyrosine 3-monooxygenase) kinase
1134:T cell receptor signaling pathway
1004:intracellular signal transduction
5774:
4995:Mitogen-activated protein kinase
3597:
3582:
3567:
3552:
3537:
3522:
3507:
3492:
3477:
3462:
3447:
3432:
3417:
2867:
1697:. PDPK1 functions downstream of
897:phospholipase activator activity
818:
811:
573:
566:
560:
537:
472:
465:
459:
434:
47:
5381:Anti-Müllerian hormone receptor
5264:(acetyl-CoA carboxylase) kinase
4936:(RNA-polymerase)-subunit kinase
4298:Beta adrenergic receptor kinase
4289:Beta adrenergic receptor kinase
1144:actin cytoskeleton organization
1099:peptidyl-serine phosphorylation
5004:Extracellular signal-regulated
829:More reference expression data
791:More reference expression data
1:
5068:P38 mitogen-activated protein
4167:cGMP-dependent protein kinase
4128:cAMP-dependent protein kinase
3824:Pyruvate dehydrogenase kinase
3770:Ataxia telangiectasia mutated
3210:10.1016/S0960-9822(99)80186-9
3144:Kobayashi T, Cohen P (1999).
3090:10.1126/science.281.5385.2042
3052:10.1016/S0960-9822(98)70274-X
2845:10.1016/S0960-9822(98)70037-5
2765:10.1016/S0378-1119(97)00411-3
2727:10.1016/S0960-9822(06)00336-8
2633:10.1016/S0960-9822(06)00122-9
2472:10.1016/s0006-291x(02)02428-2
2460:Biochem. Biophys. Res. Commun
2433:10.1126/science.281.5385.2042
558:
457:
5797:Genes on human chromosome 16
3867:AMP-activated protein kinase
2994:. 331 ( Pt 1) (1): 299–308.
2971:10.1126/science.279.5351.710
2933:10.1126/science.279.5351.707
2591:10.1016/0378-1119(94)90802-8
2031:10.1016/j.semcdb.2003.12.022
1774:The kinase domain has three
1054:transcription, DNA-templated
4782:(EC 2.7.11.21-EC 2.7.11.30)
3328:. 342 ( Pt 2) (2): 287–92.
3152:. 339 ( Pt 2) (2): 319–28.
3113:. 337 ( Pt 3) (3): 575–83.
1114:protein autophosphorylation
5823:
4709:Elongation factor 2 kinase
3673:(EC 2.7.11.1-EC 2.7.11.20)
1154:calcium-mediated signaling
31:
5652:Michaelis–Menten kinetics
5411:
5397:
5104:MAP kinase kinase kinases
4787:
4773:
4636:Myosin light-chain kinase
4342:Ca2+/calmodulin-dependent
4007:Myosin-heavy-chain kinase
3678:
3664:
3412:
3334:10.1042/0264-6021:3420287
3158:10.1042/0264-6021:3390319
3119:10.1042/0264-6021:3370575
2552:10.1042/0264-6021:3460561
2119:10.1038/s41477-020-0648-9
1937:"Mouse PubMed Reference:"
1919:"Human PubMed Reference:"
1566:
1561:
1557:
1550:
1534:
1515:
1492:
1463:
1452:
1429:
1400:
1389:
1376:
1372:
1357:
1353:
1344:
1331:
1327:
1312:
1308:
1299:
1286:
1282:
1267:
1263:
1254:
1239:
1232:
1228:
1212:
847:
843:
826:
810:
801:
788:
737:
728:
691:bronchial epithelial cell
675:
666:
636:
628:
624:
607:
594:
557:
536:
527:
523:
506:
493:
456:
433:
424:
420:
375:
372:
362:
355:
350:
91:
86:
69:
64:
59:
55:
46:
41:
5544:Diffusion-limited enzyme
5404:Dual-specificity kinases
3371:Medical Subject Headings
3252:10.1093/emboj/18.11.3024
2799:10.1074/jbc.272.48.30491
2546:. 346 Pt 3 (3): 561–76.
2388:10.1093/emboj/18.11.3024
1721:which in turn generates
1598:which is encoded by the
1528:Chr 17: 24.29 – 24.37 Mb
882:insulin receptor binding
769:anterior amygdaloid area
741:Rostral migratory stream
711:external globus pallidus
32:Not to be confused with
4827:Cyclin-dependent kinase
1089:focal adhesion assembly
1079:protein phosphorylation
872:protein kinase activity
707:mucosa of sigmoid colon
3295:10.1101/gad.13.11.1438
2895:10.1074/jbc.273.3.1496
2512:10.1074/jbc.M205141200
2336:10.1093/emboj/19.5.979
2296:10.1074/jbc.M000421200
2208:10.1074/jbc.M102940200
2167:10.1074/jbc.M200482200
912:protein kinase binding
5637:Eadie–Hofstee diagram
5570:Allosteric regulation
2675:10.1128/MCB.17.9.5648
2019:Semin. Cell Dev. Biol
1737:Phosphatidylinositols
1731:phosphatidylinositols
1719:phosphatidylinositols
1703:phosphatidylinositols
1521:Chr 16: 2.54 – 2.6 Mb
1049:hyperosmotic response
877:phospholipase binding
777:epithelium of stomach
683:middle temporal gyrus
552:Chromosome 17 (mouse)
450:Chromosome 16 (human)
5647:Lineweaver–Burk plot
4670:Phosphorylase kinase
2070:10.1093/emboj/cdf551
1986:10.1038/onc.2013.383
1955:"Entrez Gene: PDPK1"
1733:for its activities.
1625:/PKB and many other
1029:T cell costimulation
983:postsynaptic density
862:transferase activity
773:facial motor nucleus
753:ventromedial nucleus
87:List of PDB id codes
60:Available structures
3201:1999CBio....9..393B
3043:1998CBio....8..684A
2963:1998Sci...279..710S
2925:1998Sci...279..707P
2836:1998CBio....8...69A
2718:1997CBio....7..776A
2624:1997CBio....7..261A
1667:PDPK1 stands for 3-
1059:platelet activation
988:cytoplasmic vesicle
749:seminiferous tubule
5606:Enzyme superfamily
5539:Enzyme promiscuity
5281:Tropomyosin kinase
5235:Tau-protein kinase
1617:PDPK1 is a master
1334:ENSMUSG00000024122
997:Biological process
926:Cellular component
867:nucleotide binding
855:Molecular function
765:olfactory tubercle
5762:
5761:
5471:
5470:
5467:
5466:
5463:
5462:
5393:
5392:
5389:
5388:
4769:
4768:
4765:
4764:
4250:Protein kinase N1
4205:Protein kinase Cζ
3615:
3614:
3000:10.1042/bj3310299
2249:10.1021/bi010719z
1839:Protein kinase N1
1833:Protein kinase Mζ
1577:
1576:
1573:
1572:
1546:
1545:
1511:
1510:
1482:
1481:
1448:
1447:
1419:
1418:
1385:
1384:
1366:
1365:
1340:
1339:
1321:
1320:
1295:
1294:
1276:
1275:
1224:
1223:
839:
838:
835:
834:
797:
796:
784:
783:
745:nucleus accumbens
722:
721:
703:corpus epididymis
620:
619:
519:
518:
414:PDPK1 - orthologs
346:
345:
342:
341:
70:Ortholog search:
16:(Redirected from
5814:
5779:
5778:
5770:
5642:Hanes–Woolf plot
5585:Enzyme activator
5580:Enzyme inhibitor
5554:Enzyme catalysis
5498:
5491:
5484:
5475:
5413:
5399:
5046:C-Jun N-terminal
4789:
4775:
4279:Rhodopsin kinase
4270:Rhodopsin kinase
4200:Protein kinase C
4191:Protein kinase C
4176:Protein kinase G
4137:Protein kinase A
3748:Protein kinase B
3680:
3666:
3642:
3635:
3628:
3619:
3601:
3586:
3571:
3556:
3541:
3526:
3511:
3496:
3481:
3466:
3451:
3436:
3421:
3401:
3394:
3387:
3378:
3355:
3345:
3316:
3306:
3273:
3263:
3230:
3212:
3179:
3169:
3140:
3130:
3101:
3084:(5385): 2042–5.
3072:
3054:
3021:
3011:
2982:
2944:
2919:(5351): 707–10.
2907:
2897:
2872:
2871:
2865:
2847:
2821:
2811:
2801:
2776:
2747:
2729:
2696:
2686:
2653:
2635:
2602:
2573:
2563:
2525:
2524:
2514:
2490:
2484:
2483:
2454:
2445:
2444:
2427:(5385): 2042–5.
2416:
2410:
2409:
2399:
2367:
2358:
2357:
2347:
2315:
2309:
2308:
2298:
2289:(27): 20806–13.
2274:
2261:
2260:
2232:
2221:
2220:
2210:
2186:
2180:
2179:
2169:
2145:
2139:
2138:
2098:
2092:
2091:
2081:
2064:(20): 5396–407.
2049:
2043:
2042:
2014:
2008:
2007:
1997:
1965:
1959:
1958:
1951:
1945:
1944:
1933:
1927:
1926:
1915:
1909:
1899:
1888:
1878:
1780:Protein kinase C
1673:hosphoinositide-
1579:In the field of
1559:
1558:
1530:
1523:
1506:
1486:
1477:
1457:
1453:RefSeq (protein)
1443:
1423:
1414:
1394:
1370:
1351:
1325:
1306:
1280:
1261:
1230:
845:
831:
822:
815:
808:
793:
733:
731:Top expressed in
726:
699:caput epididymis
687:Brodmann area 23
679:secondary oocyte
671:
669:Top expressed in
664:
643:
626:
616:
603:
592:
577:
570:
564:
553:
541:
525:
515:
502:
491:
476:
469:
463:
452:
438:
422:
416:
367:
360:
337:
84:
78:
57:
56:
51:
39:
21:
5822:
5821:
5817:
5816:
5815:
5813:
5812:
5811:
5802:Protein kinases
5787:
5786:
5785:
5773:
5765:
5763:
5758:
5670:Oxidoreductases
5656:
5632:Enzyme kinetics
5620:
5616:List of enzymes
5589:
5558:
5529:Catalytic triad
5507:
5502:
5472:
5459:
5407:
5385:
5309:
5292:
5275:
5258:
5229:
5089:
4989:
4960:P70-S6 Kinase 1
4930:
4821:
4783:
4761:
4727:
4703:
4664:
4630:
4336:
4307:
4283:
4264:
4185:
4161:
4122:
4078:
4061:
4037:
4031:Aurora C kinase
4026:Aurora B kinase
4021:Aurora A kinase
4001:
3982:
3948:
3919:
3852:
3818:
3674:
3660:
3646:
3616:
3611:
3608:
3602:
3593:
3587:
3578:
3572:
3563:
3557:
3548:
3542:
3533:
3527:
3518:
3512:
3503:
3497:
3488:
3482:
3473:
3467:
3458:
3452:
3443:
3437:
3428:
3422:
3408:
3405:
3363:
3358:
3319:
3289:(11): 1438–52.
3276:
3246:(11): 3024–33.
3233:
3182:
3143:
3104:
3075:
3024:
2985:
2957:(5351): 710–4.
2947:
2910:
2888:(3): 1496–505.
2875:
2866:
2819:
2814:
2792:(48): 30491–7.
2779:
2759:(1–2): 149–56.
2750:
2699:
2663:Mol. Cell. Biol
2656:
2605:
2576:
2537:
2533:
2531:Further reading
2528:
2505:(42): 39360–7.
2492:
2491:
2487:
2456:
2455:
2448:
2418:
2417:
2413:
2382:(11): 3024–33.
2369:
2368:
2361:
2317:
2316:
2312:
2276:
2275:
2264:
2234:
2233:
2224:
2201:(29): 27462–9.
2188:
2187:
2183:
2160:(15): 12874–8.
2147:
2146:
2142:
2100:
2099:
2095:
2051:
2050:
2046:
2016:
2015:
2011:
1967:
1966:
1962:
1953:
1952:
1948:
1935:
1934:
1930:
1917:
1916:
1912:
1900:
1891:
1879:
1870:
1866:
1861:
1791:
1749:
1665:
1615:
1568:View/Edit Mouse
1563:View/Edit Human
1526:
1519:
1516:Location (UCSC)
1502:
1498:
1494:
1473:
1469:
1465:
1439:
1435:
1431:
1410:
1406:
1402:
1315:ENSG00000140992
1208:
1024:phosphorylation
992:
958:plasma membrane
943:cell projection
921:
917:kinase activity
902:protein binding
827:
817:
816:
789:
780:
775:
771:
767:
763:
759:
755:
751:
747:
743:
729:
718:
715:visceral pleura
713:
709:
705:
701:
697:
693:
689:
685:
681:
667:
611:
598:
591:17|17 A3.3
590:
580:
579:
578:
571:
551:
528:Gene location (
510:
497:
489:
479:
478:
477:
470:
448:
425:Gene location (
376:
363:
356:
93:
71:
37:
28:
23:
22:
15:
12:
11:
5:
5820:
5818:
5810:
5809:
5804:
5799:
5789:
5788:
5784:
5783:
5760:
5759:
5757:
5756:
5743:
5730:
5717:
5704:
5691:
5678:
5664:
5662:
5658:
5657:
5655:
5654:
5649:
5644:
5639:
5634:
5628:
5626:
5622:
5621:
5619:
5618:
5613:
5608:
5603:
5597:
5595:
5594:Classification
5591:
5590:
5588:
5587:
5582:
5577:
5572:
5566:
5564:
5560:
5559:
5557:
5556:
5551:
5546:
5541:
5536:
5531:
5526:
5521:
5515:
5513:
5509:
5508:
5503:
5501:
5500:
5493:
5486:
5478:
5469:
5468:
5465:
5464:
5461:
5460:
5458:
5457:
5452:
5447:
5442:
5437:
5432:
5427:
5421:
5419:
5409:
5408:
5402:
5395:
5394:
5391:
5390:
5387:
5386:
5384:
5383:
5378:
5373:
5368:
5363:
5358:
5353:
5348:
5347:
5346:
5341:
5336:
5331:
5320:
5318:
5317:(EC 2.7.11.30)
5311:
5310:
5308:
5307:
5303:
5301:
5300:(EC 2.7.11.29)
5294:
5293:
5291:
5290:
5286:
5284:
5283:(EC 2.7.11.28)
5277:
5276:
5274:
5273:
5269:
5267:
5266:(EC 2.7.11.27)
5260:
5259:
5257:
5256:
5251:
5246:
5240:
5238:
5237:(EC 2.7.11.26)
5231:
5230:
5228:
5227:
5222:
5217:
5216:
5215:
5210:
5205:
5200:
5195:
5190:
5185:
5175:
5174:
5173:
5168:
5163:
5158:
5148:
5147:
5146:
5141:
5136:
5131:
5126:
5121:
5116:
5111:
5100:
5098:
5097:(EC 2.7.11.25)
5091:
5090:
5088:
5087:
5086:
5085:
5080:
5075:
5065:
5064:
5063:
5058:
5053:
5043:
5042:
5041:
5036:
5031:
5026:
5021:
5016:
5011:
5000:
4998:
4997:(EC 2.7.11.24)
4991:
4990:
4988:
4987:
4982:
4977:
4972:
4967:
4962:
4957:
4952:
4947:
4941:
4939:
4938:(EC 2.7.11.23)
4932:
4931:
4929:
4928:
4923:
4918:
4913:
4908:
4903:
4898:
4893:
4888:
4883:
4878:
4873:
4868:
4863:
4858:
4853:
4848:
4843:
4838:
4832:
4830:
4829:(EC 2.7.11.22)
4823:
4822:
4820:
4819:
4814:
4809:
4804:
4798:
4796:
4795:(EC 2.7.11.21)
4785:
4784:
4778:
4771:
4770:
4767:
4766:
4763:
4762:
4760:
4759:
4754:
4749:
4744:
4738:
4736:
4735:(EC 2.7.11.21)
4729:
4728:
4726:
4725:
4720:
4714:
4712:
4711:(EC 2.7.11.20)
4705:
4704:
4702:
4701:
4696:
4691:
4686:
4681:
4675:
4673:
4672:(EC 2.7.11.19)
4666:
4665:
4663:
4662:
4657:
4652:
4647:
4641:
4639:
4638:(EC 2.7.11.18)
4632:
4631:
4629:
4628:
4623:
4618:
4613:
4608:
4603:
4598:
4593:
4588:
4583:
4578:
4573:
4568:
4563:
4558:
4553:
4548:
4543:
4538:
4533:
4528:
4523:
4518:
4513:
4508:
4503:
4498:
4493:
4488:
4483:
4478:
4473:
4468:
4463:
4458:
4453:
4448:
4443:
4438:
4433:
4428:
4423:
4418:
4413:
4408:
4403:
4398:
4393:
4388:
4383:
4378:
4373:
4368:
4363:
4358:
4353:
4347:
4345:
4344:(EC 2.7.11.17)
4338:
4337:
4335:
4334:
4329:
4324:
4318:
4316:
4315:(EC 2.7.11.16)
4309:
4308:
4306:
4305:
4300:
4294:
4292:
4291:(EC 2.7.11.15)
4285:
4284:
4282:
4281:
4275:
4273:
4272:(EC 2.7.11.14)
4266:
4265:
4263:
4262:
4257:
4252:
4247:
4242:
4237:
4232:
4227:
4222:
4217:
4212:
4207:
4202:
4196:
4194:
4193:(EC 2.7.11.13)
4187:
4186:
4184:
4183:
4178:
4172:
4170:
4169:(EC 2.7.11.12)
4163:
4162:
4160:
4159:
4154:
4149:
4144:
4139:
4133:
4131:
4130:(EC 2.7.11.11)
4124:
4123:
4121:
4120:
4115:
4110:
4105:
4100:
4095:
4089:
4087:
4086:(EC 2.7.11.10)
4080:
4079:
4077:
4076:
4072:
4070:
4063:
4062:
4060:
4059:
4054:
4048:
4046:
4039:
4038:
4036:
4035:
4034:
4033:
4028:
4023:
4012:
4010:
4003:
4002:
4000:
3999:
3993:
3991:
3984:
3983:
3981:
3980:
3975:
3970:
3965:
3959:
3957:
3950:
3949:
3947:
3946:
3941:
3936:
3930:
3928:
3921:
3920:
3918:
3917:
3916:
3915:
3910:
3905:
3897:
3896:
3895:
3890:
3882:
3881:
3880:
3875:
3863:
3861:
3854:
3853:
3851:
3850:
3845:
3840:
3835:
3829:
3827:
3820:
3819:
3817:
3816:
3815:
3814:
3804:
3803:
3802:
3797:
3792:
3787:
3777:
3772:
3767:
3766:
3765:
3760:
3755:
3745:
3740:
3735:
3730:
3725:
3720:
3715:
3710:
3705:
3700:
3695:
3689:
3687:
3676:
3675:
3669:
3662:
3661:
3647:
3645:
3644:
3637:
3630:
3622:
3613:
3612:
3610:
3609:
3603:
3596:
3594:
3588:
3581:
3579:
3573:
3566:
3564:
3558:
3551:
3549:
3543:
3536:
3534:
3528:
3521:
3519:
3513:
3506:
3504:
3498:
3491:
3489:
3483:
3476:
3474:
3468:
3461:
3459:
3453:
3446:
3444:
3438:
3431:
3429:
3423:
3416:
3413:
3410:
3409:
3406:
3404:
3403:
3396:
3389:
3381:
3375:
3374:
3362:
3361:External links
3359:
3357:
3356:
3317:
3274:
3231:
3195:(8): 393–404.
3180:
3141:
3102:
3073:
3037:(12): 684–91.
3022:
2983:
2945:
2908:
2873:
2812:
2777:
2748:
2712:(10): 776–89.
2697:
2669:(9): 5648–55.
2654:
2603:
2585:(1–2): 171–4.
2574:
2534:
2532:
2529:
2527:
2526:
2485:
2446:
2411:
2359:
2310:
2262:
2222:
2181:
2140:
2113:(5): 556–569.
2093:
2044:
2009:
1980:(34): 4330–9.
1960:
1946:
1928:
1910:
1889:
1867:
1865:
1862:
1860:
1859:
1854:
1848:
1842:
1836:
1830:
1824:
1818:
1812:
1806:
1799:
1790:
1787:
1748:
1745:
1664:
1661:
1614:
1611:
1587:refers to the
1575:
1574:
1571:
1570:
1565:
1555:
1554:
1548:
1547:
1544:
1543:
1541:
1539:
1532:
1531:
1524:
1517:
1513:
1512:
1509:
1508:
1490:
1489:
1483:
1480:
1479:
1461:
1460:
1454:
1450:
1449:
1446:
1445:
1427:
1426:
1420:
1417:
1416:
1398:
1397:
1391:
1387:
1386:
1383:
1382:
1374:
1373:
1367:
1364:
1363:
1355:
1354:
1348:
1342:
1341:
1338:
1337:
1329:
1328:
1322:
1319:
1318:
1310:
1309:
1303:
1297:
1296:
1293:
1292:
1284:
1283:
1277:
1274:
1273:
1265:
1264:
1258:
1252:
1251:
1246:
1241:
1237:
1236:
1226:
1225:
1222:
1221:
1210:
1209:
1207:
1206:
1201:
1196:
1191:
1186:
1181:
1176:
1171:
1166:
1161:
1156:
1151:
1146:
1141:
1139:cell migration
1136:
1131:
1126:
1121:
1116:
1111:
1106:
1101:
1096:
1091:
1086:
1081:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1000:
998:
994:
993:
991:
990:
985:
980:
975:
970:
965:
960:
955:
953:focal adhesion
950:
945:
940:
935:
929:
927:
923:
922:
920:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
858:
856:
852:
851:
841:
840:
837:
836:
833:
832:
824:
823:
805:
799:
798:
795:
794:
786:
785:
782:
781:
779:
778:
774:
770:
766:
762:
761:pontine nuclei
758:
754:
750:
746:
742:
738:
735:
734:
723:
720:
719:
717:
716:
712:
708:
704:
700:
696:
692:
688:
684:
680:
676:
673:
672:
660:
659:
651:
640:
634:
633:
630:RNA expression
622:
621:
618:
617:
609:
605:
604:
596:
593:
588:
582:
581:
572:
565:
559:
555:
554:
549:
543:
542:
534:
533:
521:
520:
517:
516:
508:
504:
503:
495:
492:
487:
481:
480:
471:
464:
458:
454:
453:
446:
440:
439:
431:
430:
418:
417:
374:
370:
369:
361:
353:
352:
348:
347:
344:
343:
340:
339:
89:
88:
80:
79:
68:
62:
61:
53:
52:
44:
43:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5819:
5808:
5805:
5803:
5800:
5798:
5795:
5794:
5792:
5782:
5777:
5772:
5768:
5754:
5750:
5749:
5744:
5741:
5737:
5736:
5731:
5728:
5724:
5723:
5718:
5715:
5711:
5710:
5705:
5702:
5698:
5697:
5692:
5689:
5685:
5684:
5679:
5676:
5672:
5671:
5666:
5665:
5663:
5659:
5653:
5650:
5648:
5645:
5643:
5640:
5638:
5635:
5633:
5630:
5629:
5627:
5623:
5617:
5614:
5612:
5611:Enzyme family
5609:
5607:
5604:
5602:
5599:
5598:
5596:
5592:
5586:
5583:
5581:
5578:
5576:
5575:Cooperativity
5573:
5571:
5568:
5567:
5565:
5561:
5555:
5552:
5550:
5547:
5545:
5542:
5540:
5537:
5535:
5534:Oxyanion hole
5532:
5530:
5527:
5525:
5522:
5520:
5517:
5516:
5514:
5510:
5506:
5499:
5494:
5492:
5487:
5485:
5480:
5479:
5476:
5456:
5453:
5451:
5448:
5446:
5443:
5441:
5438:
5436:
5433:
5431:
5428:
5426:
5423:
5422:
5420:
5418:
5414:
5410:
5405:
5400:
5396:
5382:
5379:
5377:
5374:
5372:
5369:
5367:
5364:
5362:
5359:
5357:
5354:
5352:
5349:
5345:
5342:
5340:
5337:
5335:
5332:
5330:
5327:
5326:
5325:
5322:
5321:
5319:
5316:
5312:
5305:
5304:
5302:
5299:
5295:
5288:
5287:
5285:
5282:
5278:
5271:
5270:
5268:
5265:
5261:
5255:
5252:
5250:
5247:
5245:
5242:
5241:
5239:
5236:
5232:
5226:
5223:
5221:
5218:
5214:
5211:
5209:
5206:
5204:
5201:
5199:
5196:
5194:
5191:
5189:
5186:
5184:
5181:
5180:
5179:
5176:
5172:
5169:
5167:
5164:
5162:
5159:
5157:
5154:
5153:
5152:
5149:
5145:
5142:
5140:
5137:
5135:
5132:
5130:
5127:
5125:
5122:
5120:
5117:
5115:
5112:
5110:
5107:
5106:
5105:
5102:
5101:
5099:
5096:
5092:
5084:
5081:
5079:
5076:
5074:
5071:
5070:
5069:
5066:
5062:
5059:
5057:
5054:
5052:
5049:
5048:
5047:
5044:
5040:
5037:
5035:
5032:
5030:
5027:
5025:
5022:
5020:
5017:
5015:
5012:
5010:
5007:
5006:
5005:
5002:
5001:
4999:
4996:
4992:
4986:
4983:
4981:
4978:
4976:
4973:
4971:
4968:
4966:
4963:
4961:
4958:
4956:
4953:
4951:
4948:
4946:
4943:
4942:
4940:
4937:
4933:
4927:
4924:
4922:
4919:
4917:
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4897:
4894:
4892:
4889:
4887:
4884:
4882:
4879:
4877:
4874:
4872:
4869:
4867:
4864:
4862:
4859:
4857:
4854:
4852:
4849:
4847:
4844:
4842:
4839:
4837:
4834:
4833:
4831:
4828:
4824:
4818:
4815:
4813:
4810:
4808:
4805:
4803:
4800:
4799:
4797:
4794:
4790:
4786:
4781:
4776:
4772:
4758:
4755:
4753:
4750:
4748:
4745:
4743:
4740:
4739:
4737:
4734:
4730:
4724:
4721:
4719:
4716:
4715:
4713:
4710:
4706:
4700:
4697:
4695:
4692:
4690:
4687:
4685:
4682:
4680:
4677:
4676:
4674:
4671:
4667:
4661:
4658:
4656:
4653:
4651:
4648:
4646:
4643:
4642:
4640:
4637:
4633:
4627:
4624:
4622:
4619:
4617:
4614:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4532:
4529:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4492:
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4417:
4414:
4412:
4409:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4389:
4387:
4384:
4382:
4379:
4377:
4374:
4372:
4369:
4367:
4364:
4362:
4359:
4357:
4354:
4352:
4349:
4348:
4346:
4343:
4339:
4333:
4330:
4328:
4325:
4323:
4320:
4319:
4317:
4314:
4310:
4304:
4301:
4299:
4296:
4295:
4293:
4290:
4286:
4280:
4277:
4276:
4274:
4271:
4267:
4261:
4258:
4256:
4253:
4251:
4248:
4246:
4243:
4241:
4238:
4236:
4233:
4231:
4228:
4226:
4223:
4221:
4218:
4216:
4213:
4211:
4208:
4206:
4203:
4201:
4198:
4197:
4195:
4192:
4188:
4182:
4179:
4177:
4174:
4173:
4171:
4168:
4164:
4158:
4155:
4153:
4150:
4148:
4145:
4143:
4140:
4138:
4135:
4134:
4132:
4129:
4125:
4119:
4116:
4114:
4111:
4109:
4106:
4104:
4101:
4099:
4096:
4094:
4091:
4090:
4088:
4085:
4081:
4074:
4073:
4071:
4069:(EC 2.7.11.9)
4068:
4064:
4058:
4055:
4053:
4050:
4049:
4047:
4045:(EC 2.7.11.8)
4044:
4040:
4032:
4029:
4027:
4024:
4022:
4019:
4018:
4017:
4016:Aurora kinase
4014:
4013:
4011:
4009:(EC 2.7.11.7)
4008:
4004:
3998:
3995:
3994:
3992:
3990:(EC 2.7.11.6)
3989:
3985:
3979:
3976:
3974:
3971:
3969:
3966:
3964:
3961:
3960:
3958:
3956:(EC 2.7.11.5)
3955:
3951:
3945:
3942:
3940:
3937:
3935:
3932:
3931:
3929:
3927:(EC 2.7.11.4)
3926:
3922:
3914:
3911:
3909:
3906:
3904:
3901:
3900:
3898:
3894:
3891:
3889:
3886:
3885:
3883:
3879:
3876:
3874:
3871:
3870:
3868:
3865:
3864:
3862:
3860:(EC 2.7.11.3)
3859:
3855:
3849:
3846:
3844:
3841:
3839:
3836:
3834:
3831:
3830:
3828:
3826:(EC 2.7.11.2)
3825:
3821:
3813:
3810:
3809:
3808:
3805:
3801:
3798:
3796:
3793:
3791:
3788:
3786:
3783:
3782:
3781:
3780:EIF-2 kinases
3778:
3776:
3773:
3771:
3768:
3764:
3761:
3759:
3756:
3754:
3751:
3750:
3749:
3746:
3744:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3714:
3711:
3709:
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3690:
3688:
3686:(EC 2.7.11.1)
3685:
3681:
3677:
3672:
3667:
3663:
3658:
3654:
3650:
3643:
3638:
3636:
3631:
3629:
3624:
3623:
3620:
3606:
3600:
3595:
3591:
3585:
3580:
3576:
3570:
3565:
3561:
3555:
3550:
3546:
3540:
3535:
3531:
3525:
3520:
3516:
3510:
3505:
3501:
3495:
3490:
3486:
3480:
3475:
3471:
3465:
3460:
3456:
3450:
3445:
3441:
3435:
3430:
3426:
3420:
3415:
3411:
3402:
3397:
3395:
3390:
3388:
3383:
3382:
3379:
3372:
3368:
3365:
3364:
3360:
3353:
3349:
3344:
3339:
3335:
3331:
3327:
3323:
3318:
3314:
3310:
3305:
3300:
3296:
3292:
3288:
3284:
3280:
3275:
3271:
3267:
3262:
3257:
3253:
3249:
3245:
3241:
3237:
3232:
3228:
3224:
3220:
3216:
3211:
3206:
3202:
3198:
3194:
3190:
3186:
3181:
3177:
3173:
3168:
3163:
3159:
3155:
3151:
3147:
3142:
3138:
3134:
3129:
3124:
3120:
3116:
3112:
3108:
3103:
3099:
3095:
3091:
3087:
3083:
3079:
3074:
3070:
3066:
3062:
3058:
3053:
3048:
3044:
3040:
3036:
3032:
3028:
3023:
3019:
3015:
3010:
3005:
3001:
2997:
2993:
2989:
2984:
2980:
2976:
2972:
2968:
2964:
2960:
2956:
2952:
2946:
2942:
2938:
2934:
2930:
2926:
2922:
2918:
2914:
2909:
2905:
2901:
2896:
2891:
2887:
2883:
2882:J. Biol. Chem
2879:
2874:
2870:
2863:
2859:
2855:
2851:
2846:
2841:
2837:
2833:
2829:
2825:
2818:
2813:
2809:
2805:
2800:
2795:
2791:
2787:
2786:J. Biol. Chem
2783:
2778:
2774:
2770:
2766:
2762:
2758:
2754:
2749:
2745:
2741:
2737:
2733:
2728:
2723:
2719:
2715:
2711:
2707:
2703:
2698:
2694:
2690:
2685:
2680:
2676:
2672:
2668:
2664:
2660:
2655:
2651:
2647:
2643:
2639:
2634:
2629:
2625:
2621:
2617:
2613:
2609:
2604:
2600:
2596:
2592:
2588:
2584:
2580:
2575:
2571:
2567:
2562:
2557:
2553:
2549:
2545:
2541:
2536:
2535:
2530:
2522:
2518:
2513:
2508:
2504:
2500:
2499:J. Biol. Chem
2496:
2489:
2486:
2481:
2477:
2473:
2469:
2466:(2): 207–15.
2465:
2461:
2453:
2451:
2447:
2442:
2438:
2434:
2430:
2426:
2422:
2415:
2412:
2407:
2403:
2398:
2393:
2389:
2385:
2381:
2377:
2373:
2366:
2364:
2360:
2355:
2351:
2346:
2341:
2337:
2333:
2330:(5): 979–88.
2329:
2325:
2321:
2314:
2311:
2306:
2302:
2297:
2292:
2288:
2284:
2283:J. Biol. Chem
2280:
2273:
2271:
2269:
2267:
2263:
2258:
2254:
2250:
2246:
2242:
2238:
2231:
2229:
2227:
2223:
2218:
2214:
2209:
2204:
2200:
2196:
2195:J. Biol. Chem
2192:
2185:
2182:
2177:
2173:
2168:
2163:
2159:
2155:
2154:J. Biol. Chem
2151:
2144:
2141:
2136:
2132:
2128:
2124:
2120:
2116:
2112:
2108:
2107:Nature Plants
2104:
2097:
2094:
2089:
2085:
2080:
2075:
2071:
2067:
2063:
2059:
2055:
2048:
2045:
2040:
2036:
2032:
2028:
2025:(2): 161–70.
2024:
2020:
2013:
2010:
2005:
2001:
1996:
1991:
1987:
1983:
1979:
1975:
1971:
1964:
1961:
1956:
1950:
1947:
1942:
1938:
1932:
1929:
1924:
1920:
1914:
1911:
1907:
1903:
1898:
1896:
1894:
1890:
1886:
1882:
1877:
1875:
1873:
1869:
1863:
1858:
1855:
1852:
1849:
1846:
1843:
1840:
1837:
1834:
1831:
1828:
1825:
1822:
1819:
1816:
1813:
1810:
1807:
1804:
1801:
1800:
1798:
1796:
1788:
1786:
1783:
1781:
1777:
1772:
1770:
1766:
1762:
1758:
1754:
1746:
1744:
1742:
1738:
1734:
1732:
1728:
1724:
1720:
1716:
1712:
1708:
1704:
1700:
1696:
1695:
1690:
1689:
1684:
1683:
1678:
1677:
1672:
1671:
1662:
1660:
1656:
1654:
1649:
1646:
1644:
1640:
1636:
1632:
1628:
1624:
1620:
1612:
1610:
1608:
1604:
1601:
1597:
1593:
1590:
1586:
1582:
1569:
1564:
1560:
1556:
1553:
1549:
1542:
1540:
1537:
1533:
1529:
1525:
1522:
1518:
1514:
1507:
1505:
1501:
1497:
1491:
1487:
1484:
1478:
1476:
1472:
1468:
1462:
1458:
1455:
1451:
1444:
1442:
1438:
1434:
1428:
1424:
1421:
1415:
1413:
1409:
1405:
1399:
1395:
1392:
1390:RefSeq (mRNA)
1388:
1381:
1380:
1375:
1371:
1368:
1362:
1361:
1356:
1352:
1349:
1347:
1343:
1336:
1335:
1330:
1326:
1323:
1317:
1316:
1311:
1307:
1304:
1302:
1298:
1291:
1290:
1285:
1281:
1278:
1272:
1271:
1266:
1262:
1259:
1257:
1253:
1250:
1247:
1245:
1242:
1238:
1235:
1231:
1227:
1220:
1216:
1211:
1205:
1202:
1200:
1197:
1195:
1192:
1190:
1187:
1185:
1182:
1180:
1177:
1175:
1172:
1170:
1167:
1165:
1162:
1160:
1157:
1155:
1152:
1150:
1147:
1145:
1142:
1140:
1137:
1135:
1132:
1130:
1127:
1125:
1122:
1120:
1117:
1115:
1112:
1110:
1107:
1105:
1102:
1100:
1097:
1095:
1092:
1090:
1087:
1085:
1082:
1080:
1077:
1075:
1072:
1070:
1067:
1065:
1062:
1060:
1057:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1001:
999:
996:
995:
989:
986:
984:
981:
979:
976:
974:
971:
969:
968:cell junction
966:
964:
961:
959:
956:
954:
951:
949:
946:
944:
941:
939:
936:
934:
931:
930:
928:
925:
924:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
859:
857:
854:
853:
850:
849:Gene ontology
846:
842:
830:
825:
821:
814:
809:
806:
804:
800:
792:
787:
776:
772:
768:
764:
760:
756:
752:
748:
744:
740:
739:
736:
732:
727:
724:
714:
710:
706:
702:
698:
695:parotid gland
694:
690:
686:
682:
678:
677:
674:
670:
665:
662:
661:
658:
656:
652:
650:
649:
645:
644:
641:
639:
635:
631:
627:
623:
615:
610:
606:
602:
597:
587:
583:
576:
569:
563:
556:
548:
544:
540:
535:
531:
526:
522:
514:
509:
505:
501:
496:
486:
482:
475:
468:
462:
455:
451:
445:
441:
437:
432:
428:
423:
419:
415:
411:
407:
403:
399:
395:
391:
387:
383:
379:
371:
366:
359:
354:
349:
338:
336:
332:
328:
324:
320:
316:
312:
308:
304:
300:
296:
292:
288:
284:
280:
276:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
90:
85:
82:
81:
77:
74:
67:
63:
58:
54:
50:
45:
40:
35:
30:
19:
5748:Translocases
5745:
5732:
5719:
5706:
5693:
5683:Transferases
5680:
5667:
5524:Binding site
4955:P70S6 kinase
3604:
3589:
3574:
3559:
3544:
3529:
3514:
3499:
3484:
3469:
3454:
3439:
3424:
3325:
3286:
3282:
3243:
3239:
3192:
3188:
3149:
3110:
3081:
3077:
3034:
3030:
2991:
2954:
2950:
2916:
2912:
2885:
2881:
2830:(2): 69–81.
2827:
2823:
2789:
2785:
2756:
2752:
2709:
2705:
2666:
2662:
2618:(4): 261–9.
2615:
2611:
2582:
2578:
2543:
2502:
2498:
2488:
2463:
2459:
2424:
2420:
2414:
2379:
2375:
2327:
2323:
2313:
2286:
2282:
2243:(2): 561–9.
2240:
2237:Biochemistry
2236:
2198:
2194:
2184:
2157:
2153:
2143:
2110:
2106:
2096:
2061:
2057:
2047:
2022:
2018:
2012:
1977:
1973:
1963:
1949:
1940:
1931:
1922:
1913:
1792:
1789:Interactions
1784:
1773:
1750:
1735:
1693:
1692:
1687:
1686:
1681:
1680:
1675:
1674:
1669:
1668:
1666:
1657:
1653:PI3K pathway
1650:
1647:
1616:
1599:
1591:
1584:
1581:biochemistry
1578:
1500:NP_001273591
1496:NP_001074242
1493:
1467:NP_001248745
1464:
1437:NM_001286662
1433:NM_001080773
1430:
1404:NM_001261816
1401:
1377:
1358:
1332:
1313:
1287:
1268:
1248:
1243:
653:
646:
373:External IDs
92:
29:
5519:Active site
5406:(EC 2.7.12)
4793:Polo kinase
4733:Polo kinase
3407:PDB gallery
1655:(PTEN+/-).
1645:signaling.
1627:AGC kinases
963:nucleoplasm
907:ATP binding
612:24,369,898
599:24,292,654
351:Identifiers
5791:Categories
5722:Isomerases
5696:Hydrolases
5563:Regulation
4084:IκB kinase
3659:2.7.11-12)
3326:Biochem. J
3189:Curr. Biol
3150:Biochem. J
3111:Biochem. J
3031:Curr. Biol
2992:Biochem. J
2824:Curr. Biol
2706:Curr. Biol
2612:Curr. Biol
2544:Biochem. J
1908:, May 2017
1887:, May 2017
1864:References
1629:including
978:perikaryon
657:(ortholog)
511:2,603,188
498:2,537,979
394:HomoloGene
5807:EC 2.7.11
5601:EC number
4210:PKC alpha
3283:Genes Dev
2135:218593545
1757:PH domain
1753:PH domain
1747:Structure
1679:ependent
1663:Etymology
1607:melanomas
1504:NP_035192
1475:NP_112558
1471:NP_002604
1441:NM_011062
1412:NM_031268
1408:NM_002613
1234:Orthologs
933:cytoplasm
402:GeneCards
5625:Kinetics
5549:Cofactor
5512:Activity
4566:KIAA0999
4461:MAPKAPK5
4456:MAPKAPK3
4451:MAPKAPK2
3352:10455013
3313:10364160
3270:10357815
3227:16473977
3219:10226025
3176:10191262
3069:13936854
2862:18688785
2570:10698680
2521:12177059
2480:12387817
2406:10357815
2354:10698939
2305:10764742
2257:11781095
2217:11313365
2176:11825911
2127:32393881
2088:12374740
2039:15209375
2004:24037523
1974:Oncogene
1904:–
1883:–
1851:SLC9A3R2
1795:interact
1613:Function
1552:Wikidata
1213:Sources:
948:membrane
5781:Biology
5735:Ligases
5505:Enzymes
5225:MAP3K14
5203:MAP3K11
5198:MAP3K10
5188:MAP3K13
5183:MAP3K12
4985:RPS6KC1
4980:RPS6KA1
4975:RPS6KA3
4970:RPS6KA2
4965:RPS6KB2
4950:RPS6KA4
4945:RPS6KA5
4596:Kalirin
4561:SNF1LK2
3800:EIF2AK4
3795:EIF2AK3
3649:Kinases
3343:1220463
3261:1171384
3197:Bibcode
3167:1220160
3137:9895304
3128:1220012
3098:9748166
3078:Science
3061:9637919
3039:Bibcode
3018:9512493
3009:1219352
2979:9445477
2959:Bibcode
2951:Science
2941:9445476
2921:Bibcode
2913:Science
2904:9430688
2854:9427642
2832:Bibcode
2808:9374542
2773:9373149
2744:1167390
2736:9368760
2714:Bibcode
2693:9271440
2650:2094414
2642:9094314
2620:Bibcode
2599:8125298
2561:1220886
2441:9748166
2421:Science
2397:1171384
1995:3955742
1906:Ensembl
1885:Ensembl
1685:rotein
1643:insulin
1589:protein
1346:UniProt
1301:Ensembl
1240:Species
1219:QuickGO
973:nucleus
938:cytosol
632:pattern
490:16p13.3
390:1338068
358:Aliases
36:(PDK1).
5767:Portal
5709:Lyases
5455:MAP2K7
5450:MAP2K6
5445:MAP2K5
5440:MAP2K4
5435:MAP2K3
5430:MAP2K2
5425:MAP2K1
5376:ACVRL1
5371:ACVR2B
5366:ACVR2A
5361:ACVR1C
5356:ACVR1B
5339:BMPR1B
5334:BMPR1A
5208:MAP3K7
5193:MAP3K9
5144:MAP3K8
5139:MAP3K7
5134:MAP3K6
5129:MAP3K5
5124:MAP3K4
5119:MAP3K3
5114:MAP3K2
5109:MAP3K1
5083:MAPK14
5078:MAPK13
5073:MAPK11
5061:MAPK10
5039:MAPK15
5034:MAPK12
4926:CDC2L1
4901:CDC2L5
4576:SNF1LK
4401:CAMK2G
4396:CAMK2D
4391:CAMK2B
4386:CAMK2A
4376:CAMK1G
4371:CAMK1D
4366:CAMK1B
4361:CAMK1A
4215:PRKCB1
4152:PRKACA
4147:PRKACB
4142:PRKACG
4118:IKBKAP
3944:BCKDHB
3939:BCKDHA
3913:PRKAG3
3908:PRKAG2
3903:PRKAG1
3893:PRKAB2
3888:PRKAB1
3878:PRKAA2
3873:PRKAA1
3718:STK38L
3373:(MeSH)
3350:
3340:
3311:
3304:316759
3301:
3268:
3258:
3240:EMBO J
3225:
3217:
3174:
3164:
3135:
3125:
3096:
3067:
3059:
3016:
3006:
2977:
2939:
2902:
2860:
2852:
2806:
2771:
2742:
2734:
2691:
2684:232413
2681:
2648:
2640:
2597:
2568:
2558:
2519:
2478:
2439:
2404:
2394:
2376:EMBO J
2352:
2345:305637
2342:
2324:EMBO J
2303:
2255:
2215:
2174:
2133:
2125:
2086:
2079:129083
2076:
2058:EMBO J
2037:
2002:
1992:
1853:, and
1815:PRKACA
1797:with:
1776:ligand
1755:. The
1691:inase
1619:kinase
1596:enzyme
1538:search
1536:PubMed
1379:Q9Z2A0
1360:O15530
1256:Entrez
803:BioGPS
757:zygote
382:605213
5661:Types
5417:MAP2K
5351:ACVR1
5344:BMPR2
5329:BMPR1
5254:GSK-3
5095:MAP3K
5056:MAPK9
5051:MAPK8
5029:MAPK7
5024:MAPK6
5019:MAPK4
5014:MAPK3
5009:MAPK1
4921:PFTK1
4916:PCTK3
4911:PCTK2
4906:PCTK1
4896:CDK12
4891:CDK10
4866:CDKL5
4846:CDKL2
4723:STK19
4718:EEF2K
4699:PHKG2
4694:PHKG1
4684:PHKA2
4679:PHKA1
4660:MYLK4
4655:MYLK3
4650:MYLK2
4626:DCLK1
4621:Titin
4611:TRIB3
4606:TRIB2
4601:TRIB1
4591:TSSK2
4571:STK40
4556:PSKH1
4551:PRKD3
4546:PRKD2
4526:PHKG2
4521:PHKG1
4511:OBSCN
4506:NUAK2
4501:NUAK1
4496:MKNK2
4491:MKNK1
4481:MARK4
4476:MARK3
4471:MARK2
4466:MARK1
4446:STK11
4441:DAPK3
4436:DAPK2
4431:DAPK1
4426:CHEK2
4421:CHEK1
4406:CAMK4
4381:CAMK2
4356:CAMK1
4351:BRSK2
4245:PRKCQ
4240:PRKCI
4235:PRKCG
4230:PRKCH
4225:PRKCE
4220:PRKCD
4181:PRKG1
4113:IKBKG
4108:IKBKE
4057:STK10
4052:FASTK
3978:IDH3G
3973:IDH3B
3968:IDH3A
3934:BCKDK
3728:ROCK1
3713:STK38
3708:MAST2
3703:MAST1
3698:LATS2
3693:LATS1
3223:S2CID
3065:S2CID
2858:S2CID
2820:(PDF)
2740:S2CID
2646:S2CID
2131:S2CID
1857:YWHAH
1827:PRKCI
1821:PRKCD
1600:PDPK1
1594:, an
1585:PDPK1
1289:18607
1249:Mouse
1244:Human
1215:Amigo
655:Mouse
648:Human
595:Start
530:Mouse
494:Start
427:Human
406:PDPK1
398:37643
365:PDPK1
42:PDPK1
18:PDPK1
5753:list
5746:EC7
5740:list
5733:EC6
5727:list
5720:EC5
5714:list
5707:EC4
5701:list
5694:EC3
5688:list
5681:EC2
5675:list
5668:EC1
5244:TPK1
5220:CDC7
5178:MLKs
5171:KSR2
5166:KSR1
5161:BRAF
5156:ARAF
5151:RAFs
4886:CDK9
4881:CDK8
4876:CDK7
4871:CDK6
4861:CDK5
4856:CDK4
4851:CDK3
4841:CDK2
4836:CDK1
4817:PLK4
4812:PLK3
4807:PLK2
4802:PLK1
4757:PLK4
4752:PLK3
4747:PLK2
4742:PLK1
4689:PHKB
4645:MYLK
4616:TRIO
4586:SPEG
4581:SNRK
4541:PKD1
4536:PIM2
4531:PIM1
4516:PASK
4486:MELK
4416:CASK
4411:MLCK
4332:GRK6
4327:GRK5
4322:GRK4
4260:PKN3
4255:PKN2
4157:PRKY
4103:TBK1
4098:IKK2
4093:CHUK
3997:STK4
3963:IDH2
3848:PDK4
3843:PDK3
3838:PDK2
3833:PDK1
3812:WEE1
3807:Wee1
3775:mTOR
3763:AKT3
3758:AKT2
3753:AKT1
3743:SGK3
3738:SGK2
3605:2biy
3590:1z5m
3575:1w1h
3560:1w1g
3545:1w1d
3530:1uvr
3515:1uu9
3500:1uu8
3485:1uu7
3470:1uu3
3455:1okz
3440:1oky
3425:1h1w
3348:PMID
3309:PMID
3266:PMID
3215:PMID
3172:PMID
3133:PMID
3094:PMID
3057:PMID
3014:PMID
2975:PMID
2937:PMID
2900:PMID
2850:PMID
2804:PMID
2769:PMID
2753:Gene
2732:PMID
2689:PMID
2638:PMID
2595:PMID
2579:Gene
2566:PMID
2517:PMID
2476:PMID
2437:PMID
2402:PMID
2350:PMID
2301:PMID
2253:PMID
2213:PMID
2172:PMID
2123:PMID
2084:PMID
2035:PMID
2000:PMID
1809:PKN2
1803:AKT1
1763:and
1725:and
1715:PI3K
1709:and
1699:PI3K
1603:gene
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