244:
221:
118:
143:
502:
495:
250:
149:
1418:
969:
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This
970:
protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least two alternatively spliced transcripts encoding distinct isoforms have been found for this gene.
1077:
Ohishi K, Inoue N, Endo Y, Fujita T, Takeda J, Kinoshita T (Oct 1995). "Structure and chromosomal localization of the GPI-anchor synthesis gene PIGF and its pseudogene psi PIGF".
1268:"High-resolution quantitative computed tomography demonstrating selective enhancement of medium-size collaterals by placental growth factor-1 in the mouse ischemic hindlimb"
1266:
Li W, Shen W, Gill R, Corbly A, Jones B, Belagaje R, Zhang Y, Tang S, Chen Y, Zhai Y, Wang G, Wagle A, Hui K, Westmore M, Hanson J, Chen YF, Simons M, Singh J (May 2006).
1301:
Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, Kang PM, Toltl L, Belikoff B, Buras J, Simms BT, Mizgerd JP, Carmeliet P, Karumanchi SA, Aird WC (Jun 2006).
257:
156:
1382:
Mohammed KA, Nasreen N, Tepper RS, Antony VB (Feb 2007). "Cyclic stretch induces PlGF expression in bronchial airway epithelial cells via nitric oxide release".
680:
79:
661:
1487:
1463:
1059:
1041:
1482:
1114:"Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy"
243:
1349:"Chimeric VEGF-E(NZ7)/PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation"
895:
888:
220:
1156:
1028:
1007:
1175:
Kinoshita T, Takahashi M, Inoue N, Miyata T, Takeda J (Feb 1994). "Expression cloning of genes for GPI-anchor biosynthesis".
1024:
142:
117:
1198:"Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol"
1003:
59:
256:
155:
1456:
249:
148:
725:
67:
1347:
Zheng Y, Murakami M, Takahashi H, Yamauchi M, Kiba A, Yamaguchi S, Yabana N, Alitalo K, Shibuya M (Sep 2006).
706:
1449:
131:
46:
1303:"Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality"
1233:"GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol"
91:
871:
850:
846:
820:
799:
795:
1399:
1370:
1335:
1289:
1254:
1219:
1184:
1135:
1094:
39:
1433:
1391:
1360:
1325:
1317:
1279:
1244:
1209:
1125:
1086:
501:
336:
267:
211:
166:
494:
311:
87:
1302:
1365:
1348:
1330:
1284:
1267:
1130:
1113:
595:
590:
574:
569:
564:
559:
543:
1476:
530:
1429:
329:
108:
71:
95:
1064:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1046:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1395:
412:
228:
125:
75:
1157:"Entrez Gene: PIGF phosphatidylinositol glycan anchor biosynthesis, class F"
625:
472:
350:
295:
282:
194:
181:
83:
1403:
1374:
1339:
1293:
1258:
1249:
1232:
1223:
1214:
1197:
1090:
1188:
1139:
1098:
935:
930:
1321:
1231:
Shishioh N, Hong Y, Ohishi K, Ashida H, Maeda Y, Kinoshita T (Mar 2005).
919:
770:
751:
1196:
Hong Y, Maeda Y, Watanabe R, Inoue N, Ohishi K, Kinoshita T (Jul 2000).
951:
737:
692:
1384:
American
Journal of Physiology. Lung Cellular and Molecular Physiology
903:
647:
1417:
610:
606:
1425:
979:
958:
63:
510:
50:, phosphatidylinositol glycan anchor biosynthesis class F, OORS
948:
Phosphatidylinositol-glycan biosynthesis class F protein
319:
1437:
484:
1177:
Brazilian
Journal of Medical and Biological Research
1112:Inoue N, Kinoshita T, Orii T, Takeda J (Apr 1993).
864:
839:
813:
788:
1353:Arteriosclerosis, Thrombosis, and Vascular Biology
1020:
1018:
1016:
999:
997:
995:
266:
165:
16:Protein-coding gene in the species Homo sapiens
1025:GRCm38: Ensembl release 89: ENSMUSG00000024145
1457:
8:
1004:GRCh38: Ensembl release 89: ENSG00000151665
1464:
1450:
621:
526:
307:
206:
103:
1364:
1329:
1283:
1248:
1213:
1129:
1151:
1149:
596:preassembly of GPI anchor in ER membrane
991:
544:ethanolaminephosphotransferase activity
20:
271:
232:
227:
170:
129:
124:
7:
1414:
1412:
1310:The Journal of Experimental Medicine
1237:The Journal of Biological Chemistry
1202:The Journal of Biological Chemistry
1118:The Journal of Biological Chemistry
1436:. You can help Knowledge (XXG) by
1366:10.1161/01.ATV.0000233336.53574.a1
861:
836:
810:
785:
761:
742:
716:
697:
671:
652:
489:
407:
345:
324:
14:
1285:10.1161/CIRCULATIONAHA.105.586818
954:that in humans is encoded by the
1416:
500:
493:
255:
248:
242:
219:
154:
147:
141:
116:
591:GPI anchor biosynthetic process
565:endoplasmic reticulum membrane
560:integral component of membrane
511:More reference expression data
473:More reference expression data
1:
1488:Human chromosome 2 gene stubs
1131:10.1016/S0021-9258(18)53122-7
240:
139:
1483:Genes on human chromosome 2
397:stromal cell of endometrium
1504:
1411:
1396:10.1152/ajplung.00075.2006
389:mucosa of transverse colon
1060:"Mouse PubMed Reference:"
1042:"Human PubMed Reference:"
934:
929:
925:
918:
902:
883:
868:
843:
832:
817:
792:
781:
768:
764:
749:
745:
736:
723:
719:
704:
700:
691:
678:
674:
659:
655:
646:
631:
624:
620:
604:
529:
525:
508:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
896:Chr 17: 87.3 – 87.33 Mb
889:Chr 2: 46.58 – 46.62 Mb
1250:10.1074/jbc.M413755200
1215:10.1074/jbc.M001913200
1091:10.1006/geno.1995.9929
570:endoplasmic reticulum
451:epithelium of stomach
273:17 E4|17 56.9 cM
234:Chromosome 17 (mouse)
1322:10.1084/jem.20060375
377:right adrenal cortex
132:Chromosome 2 (human)
1208:(27): 20911–20919.
439:seminiferous tubule
385:left adrenal cortex
369:right adrenal gland
365:islet of Langerhans
1424:This article on a
726:ENSMUSG00000024145
584:Biological process
553:Cellular component
537:Molecular function
381:left adrenal gland
1445:
1444:
1278:(20): 2445–2453.
1243:(10): 9728–9734.
1124:(10): 6882–6885.
945:
944:
941:
940:
914:
913:
879:
878:
858:
857:
828:
827:
807:
806:
777:
776:
758:
757:
732:
731:
713:
712:
687:
686:
668:
667:
616:
615:
521:
520:
517:
516:
479:
478:
466:
465:
404:
403:
302:
301:
201:
200:
1495:
1466:
1459:
1452:
1420:
1413:
1407:
1378:
1368:
1359:(9): 2019–2026.
1343:
1333:
1316:(6): 1447–1458.
1307:
1297:
1287:
1262:
1252:
1227:
1217:
1192:
1161:
1160:
1153:
1144:
1143:
1133:
1109:
1103:
1102:
1074:
1068:
1067:
1056:
1050:
1049:
1038:
1032:
1022:
1011:
1001:
927:
926:
898:
891:
874:
862:
853:
837:
833:RefSeq (protein)
823:
811:
802:
786:
762:
743:
717:
698:
672:
653:
622:
527:
513:
504:
497:
490:
475:
455:primitive streak
427:secondary oocyte
415:
413:Top expressed in
408:
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
96:PIGF - orthologs
49:
42:
21:
1503:
1502:
1498:
1497:
1496:
1494:
1493:
1492:
1473:
1472:
1471:
1470:
1410:
1390:(2): L559–566.
1381:
1346:
1305:
1300:
1265:
1230:
1195:
1174:
1170:
1168:Further reading
1165:
1164:
1155:
1154:
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1110:
1106:
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1071:
1058:
1057:
1053:
1040:
1039:
1035:
1023:
1014:
1002:
993:
988:
976:
967:
936:View/Edit Mouse
931:View/Edit Human
894:
887:
884:Location (UCSC)
870:
849:
845:
819:
798:
794:
707:ENSG00000151665
600:
579:
548:
509:
499:
498:
471:
462:
457:
453:
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441:
437:
433:
429:
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379:
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371:
367:
363:
349:
293:
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272:
262:
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253:
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210:Gene location (
192:
179:
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161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
17:
12:
11:
5:
1501:
1499:
1491:
1490:
1485:
1475:
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1469:
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1461:
1454:
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1443:
1442:
1421:
1409:
1408:
1379:
1344:
1298:
1263:
1228:
1193:
1183:(2): 127–132.
1171:
1169:
1166:
1163:
1162:
1145:
1104:
1085:(3): 804–807.
1069:
1051:
1033:
1012:
990:
989:
987:
984:
983:
982:
975:
972:
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963:
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790:
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505:
487:
481:
480:
477:
476:
468:
467:
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463:
461:
460:
456:
452:
448:
444:
443:primary oocyte
440:
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
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264:
263:
254:
247:
241:
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186:
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153:
146:
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136:
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128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
1500:
1489:
1486:
1484:
1481:
1480:
1478:
1467:
1462:
1460:
1455:
1453:
1448:
1447:
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1439:
1435:
1431:
1427:
1422:
1419:
1415:
1405:
1401:
1397:
1393:
1389:
1385:
1380:
1376:
1372:
1367:
1362:
1358:
1354:
1350:
1345:
1341:
1337:
1332:
1327:
1323:
1319:
1315:
1311:
1304:
1299:
1295:
1291:
1286:
1281:
1277:
1273:
1269:
1264:
1260:
1256:
1251:
1246:
1242:
1238:
1234:
1229:
1225:
1221:
1216:
1211:
1207:
1203:
1199:
1194:
1190:
1186:
1182:
1178:
1173:
1172:
1167:
1158:
1152:
1150:
1146:
1141:
1137:
1132:
1127:
1123:
1119:
1115:
1108:
1105:
1100:
1096:
1092:
1088:
1084:
1080:
1073:
1070:
1065:
1061:
1055:
1052:
1047:
1043:
1037:
1034:
1030:
1026:
1021:
1019:
1017:
1013:
1009:
1005:
1000:
998:
996:
992:
985:
981:
978:
977:
973:
971:
964:
962:
960:
957:
953:
949:
937:
932:
928:
924:
921:
917:
910:
908:
905:
901:
897:
893:
890:
886:
882:
875:
873:
867:
863:
860:
854:
852:
848:
842:
838:
835:
831:
824:
822:
816:
812:
809:
803:
801:
797:
791:
787:
784:
782:RefSeq (mRNA)
780:
773:
772:
767:
763:
760:
754:
753:
748:
744:
741:
739:
735:
728:
727:
722:
718:
715:
709:
708:
703:
699:
696:
694:
690:
683:
682:
677:
673:
670:
664:
663:
658:
654:
651:
649:
645:
642:
639:
637:
634:
630:
627:
623:
619:
612:
608:
603:
597:
594:
592:
589:
588:
586:
583:
582:
576:
573:
571:
568:
566:
563:
561:
558:
557:
555:
552:
551:
545:
542:
541:
539:
536:
535:
532:
531:Gene ontology
528:
524:
512:
507:
503:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
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178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
1438:expanding it
1430:chromosome 2
1423:
1387:
1383:
1356:
1352:
1313:
1309:
1275:
1271:
1240:
1236:
1205:
1201:
1180:
1176:
1121:
1117:
1107:
1082:
1078:
1072:
1063:
1054:
1045:
1036:
968:
955:
947:
946:
869:
844:
818:
793:
769:
750:
724:
705:
679:
660:
640:
635:
435:spermatocyte
335:
328:
55:External IDs
18:
1272:Circulation
447:Paneth cell
294:87,332,834
281:87,304,684
193:46,617,055
180:46,580,937
33:Identifiers
1477:Categories
1031:, May 2017
1010:, May 2017
986:References
339:(ortholog)
76:HomoloGene
1428:on human
872:NP_032864
851:NP_775097
847:NP_002634
821:NM_008838
800:NM_173074
796:NM_002643
626:Orthologs
423:spermatid
84:GeneCards
1404:17028267
1375:16794222
1340:16702604
1294:16702473
1259:15632136
1224:10781593
1079:Genomics
1027:–
1006:–
974:See also
965:Function
920:Wikidata
605:Sources:
575:membrane
459:yolk sac
393:monocyte
1331:2118329
1189:8081220
1140:8463218
1099:8575782
1029:Ensembl
1008:Ensembl
952:protein
738:UniProt
693:Ensembl
632:Species
611:QuickGO
314:pattern
40:Aliases
1402:
1373:
1338:
1328:
1292:
1257:
1222:
1187:
1138:
1097:
906:search
904:PubMed
771:O09101
752:Q07326
648:Entrez
485:BioGPS
431:zygote
373:rectum
361:oocyte
64:600153
1432:is a
1306:(PDF)
950:is a
681:18701
641:Mouse
636:Human
607:Amigo
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
80:31103
72:99462
1434:stub
1426:gene
1400:PMID
1371:PMID
1336:PMID
1290:PMID
1255:PMID
1220:PMID
1185:PMID
1136:PMID
1095:PMID
980:VEGF
959:gene
956:PIGF
662:5281
320:Bgee
268:Band
229:Chr.
172:2p21
167:Band
126:Chr.
88:PIGF
60:OMIM
47:PIGF
24:PIGF
1392:doi
1388:292
1361:doi
1326:PMC
1318:doi
1314:203
1280:doi
1276:113
1245:doi
1241:280
1210:doi
1206:275
1126:doi
1122:268
1087:doi
290:End
189:End
92:OMA
68:MGI
1479::
1398:.
1386:.
1369:.
1357:26
1355:.
1351:.
1334:.
1324:.
1312:.
1308:.
1288:.
1274:.
1270:.
1253:.
1239:.
1235:.
1218:.
1204:.
1200:.
1181:27
1179:.
1148:^
1134:.
1120:.
1116:.
1093:.
1083:29
1081:.
1062:.
1044:.
1015:^
994:^
961:.
609:/
296:bp
283:bp
195:bp
182:bp
90:;
86::
82:;
78::
74:;
70::
66:;
62::
1465:e
1458:t
1451:v
1440:.
1406:.
1394::
1377:.
1363::
1342:.
1320::
1296:.
1282::
1261:.
1247::
1226:.
1212::
1191:.
1159:.
1142:.
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