321:
298:
195:
220:
579:
572:
327:
226:
4369:
3593:
Fressart V, Duthoit G, Donal E, Probst V, Deharo JC, Chevalier P, Klug D, Dubourg O, Delacretaz E, Cosnay P, Scanu P, Extramiana F, Keller D, Hidden-Lucet F, Simon F, Bessirard V, Roux-Buisson N, Hebert JL, Azarine A, Casset-Senon D, Rouzet F, Lecarpentier Y, Fontaine G, Coirault C, Frank R, Hainque
4243:
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T,
2108:
Groeneweg JA, Ummels A, Mulder M, Bikker H, van der Smagt JJ, van Mil AM, Homfray T, Post JG, Elvan A, van der
Heijden JF, Houweling AC, Jongbloed JD, Wilde AA, van Tintelen JP, Hauer RN, Dooijes D (November 2014). "Functional assessment of potential splice site variants in arrhythmogenic right
1445:
Plakophilin-2 over time has shown to be more than components of cell-cell junctions; rather the plakophilins are emerging as versatile scaffolds for various signaling pathways that more globally modulate diverse cellular activities. Plakophilin-2 has shown to localize to nuclei, in addition to
3297:
Cox MG, van der Zwaag PA, van der Werf C, van der Smagt JJ, Noorman M, Bhuiyan ZA, Wiesfeld AC, Volders PG, van Langen IM, Atsma DE, Dooijes D, van den
Wijngaard A, Houweling AC, Jongbloed JD, Jordaens L, Cramer MJ, Doevendans PA, de Bakker JM, Wilde AA, van Tintelen JP, Hauer RN (June 2011).
70:
3339:
Lahtinen AM, Lehtonen E, Marjamaa A, Kaartinen M, Heliö T, Porthan K, Oikarinen L, Toivonen L, Swan H, Jula A, Peltonen L, Palotie A, Salomaa V, Kontula K (August 2011). "Population-prevalent desmosomal mutations predisposing to arrhythmogenic right ventricular cardiomyopathy".
3557:
Bauce B, Nava A, Beffagna G, Basso C, Lorenzon A, Smaniotto G, De
Bortoli M, Rigato I, Mazzotti E, Steriotis A, Marra MP, Towbin JA, Thiene G, Danieli GA, Rampazzo A (January 2010). "Multiple mutations in desmosomal proteins encoding genes in arrhythmogenic right ventricular
2916:
Gerull B, Heuser A, Wichter T, Paul M, Basson CT, McDermott DA, Lerman BB, Markowitz SM, Ellinor PT, MacRae CA, Peters S, Grossmann KS, Drenckhahn J, Michely B, Sasse-Klaassen S, Birchmeier W, Dietz R, Breithardt G, Schulze-Bahr E, Thierfelder L (November 2004).
2740:
Zhou X, Chen M, Song H, Wang B, Chen H, Wang J, Wang W, Feng S, Zhang F, Ju W, Li M, Gu K, Cao K, Wang DW, Yang B (April 2015). "Comprehensive analysis of desmosomal gene mutations in Han
Chinese patients with arrhythmogenic right ventricular cardiomyopathy".
3300:"Arrhythmogenic right ventricular dysplasia/cardiomyopathy: pathogenic desmosome mutations in index-patients predict outcome of family screening: Dutch arrhythmogenic right ventricular dysplasia/cardiomyopathy genotype-phenotype follow-up study"
3010:
Kannankeril PJ, Bhuiyan ZA, Darbar D, Mannens MM, Wilde AA, Roden DM (August 2006). "Arrhythmogenic right ventricular cardiomyopathy due to a novel plakophilin 2 mutation: wide spectrum of disease in mutation carriers within a family".
2776:
Li Mura IE, Bauce B, Nava A, Fanciulli M, Vazza G, Mazzotti E, Rigato I, De
Bortoli M, Beffagna G, Lorenzon A, Calore M, Dazzo E, Nobile C, Mostacciuolo ML, Corrado D, Basso C, Daliento L, Thiene G, Rampazzo A (November 2013).
3081:
van
Tintelen JP, Entius MM, Bhuiyan ZA, Jongbloed R, Wiesfeld AC, Wilde AA, van der Smagt J, Boven LG, Mannens MM, van Langen IM, Hofstra RM, Otterspoor LC, Doevendans PA, Rodriguez LM, van Gelder IC, Hauer RN (April 2006).
3215:"Arrhythmogenic right ventricular cardiomyopathy caused by deletions in plakophilin-2 and plakoglobin (Naxos disease) in families from Greece and Cyprus: genotype-phenotype relations, diagnostic features and prognosis"
4004:
Bonné S, van Hengel J, van Roy F (2000). "Assignment of the plakophilin-2 gene (PKP2) and a plakophilin-2 pseudogene (PKP2P1) to human chromosome bands 12p11 and 12p13, respectively, by in situ hybridization".
1540:
in cardiac cells, which was coordinate with decreased electrical coupling of cells and decreased adhesion strength. These studies were further supported by an investigation in a mouse model harboring a
2867:
van der Zwaag PA, Cox MG, van der Werf C, Wiesfeld AC, Jongbloed JD, Dooijes D, Bikker H, Jongbloed R, Suurmeijer AJ, van den Berg MP, Hofstra RM, Hauer RN, Wilde AA, van
Tintelen JP (December 2010).
3046:
Lahtinen AM, Lehtonen A, Kaartinen M, Toivonen L, Swan H, Widén E, Lehtonen E, Lehto VP, Kontula K (May 2008). "Plakophilin-2 missense mutations in arrhythmogenic right ventricular cardiomyopathy".
3725:
Cerrone M, Lin X, Zhang M, Agullo-Pascual E, Pfenniger A, Chkourko Gusky H, Novelli V, Kim C, Tirasawadichai T, Judge DP, Rothenberg E, Chen HS, Napolitano C, Priori SG, Delmar M (March 2014).
3416:
van
Tintelen JP, Hofstra RM, Wiesfeld AC, van den Berg MP, Hauer RN, Jongbloed JD (May 2007). "Molecular genetics of arrhythmogenic right ventricular cardiomyopathy: emerging horizon?".
4042:
Hofmann I, Mertens C, Brettel M, Nimmrich V, Schnölzer M, Herrmann H (2000). "Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis".
3508:
den Haan AD, Tan BY, Zikusoka MN, Lladó LI, Jain R, Daly A, Tichnell C, James C, Amat-Alarcon N, Abraham T, Russell SD, Bluemke DA, Calkins H, Dalal D, Judge DP (October 2009).
3377:"Clinical and genetic characterization of families with arrhythmogenic right ventricular dysplasia/cardiomyopathy provides novel insights into patterns of disease expression"
1454:. Studies have shown that plakkophillin-2 is found in the nucleoplasm, complexed in the RNA polymerase III holoenzyme with the largest subunit of RNA polymerase III, termed
4157:
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004).
334:
233:
4287:
Dalal D, Molin LH, Piccini J, Tichnell C, James C, Bomma C, Prakasa K, Towbin JA, Marcus FI, Spevak PJ, Bluemke DA, Abraham T, Russell SD, Calkins H, Judge DP (2006).
2023:
3676:
Brun F, Barnes CV, Sinagra G, Slavov D, Barbati G, Zhu X, Graw SL, Spezzacatene A, Pinamonti B, Merlo M, Salcedo EE, Sauer WH, Taylor MR, Mestroni L (October 2014).
1993:
4396:
1693:
1663:
1629:
1613:
1242:
6718:
2869:"Recurrent and founder mutations in the Netherlands : Plakophilin-2 p.Arg79X mutation causing arrhythmogenic right ventricular cardiomyopathy/dysplasia"
3213:
Antoniades L, Tsatsopoulou A, Anastasakis A, Syrris P, Asimaki A, Panagiotakos D, Zambartas C, Stefanadis C, McKenna WJ, Protonotarios N (September 2006).
2637:
Cerrone M, Noorman M, Lin X, Chkourko H, Liang FX, van der Nagel R, Hund T, Birchmeier W, Mohler P, van Veen TA, van Rijen HV, Delmar M (September 2012).
2689:
Hong M, Bao L, Kefaloyianni E, Agullo-Pascual E, Chkourko H, Foster M, Taskin E, Zhandre M, Reid DA, Rothenberg E, Delmar M, Coetzee WA (November 2012).
932:
913:
156:
2828:"PKP2 mutations in sudden death from arrhythmogenic right ventricular cardiomyopathy (ARVC) and sudden unexpected death with negative autopsy (SUDNA)"
1399:
in mice severely disrupts normal heart morphogenesis. Mutant mice are embryonic lethal and exhibit deficits in the formation of adhering junctions in
4159:"Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization"
3946:
Mertens C, Kuhn C, Moll R, Schwetlick I, Franke WW (1999). "Desmosomal plakophilin 2 as a differentiation marker in normal and malignant tissues".
2958:
Syrris P, Ward D, Asimaki A, Sen-Chowdhry S, Ebrahim HY, Evans A, Hitomi N, Norman M, Pantazis A, Shaw AL, Elliott PM, McKenna WJ (January 2006).
4246:"Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes"
3975:
Schmidt A, Langbein L, Prätzel S, Rode M, Rackwitz HR, Franke WW (1999). "Plakophilin 3--a novel cell-type-specific desmosomal plaque protein".
3596:"Desmosomal gene analysis in arrhythmogenic right ventricular dysplasia/cardiomyopathy: spectrum of mutations and clinical impact in practice"
6713:
1909:
5024:
4322:
Dalal D, James C, Devanagondi R, Tichnell C, Tucker A, Prakasa K, Spevak PJ, Bluemke DA, Abraham T, Russell SD, Calkins H, Judge DP (2006).
2163:"Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling"
1891:
3917:
Bonné S, van Hengel J, van Roy F (1998). "Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily".
320:
67:
4389:
1140:
1147:
297:
1675:
1979:
3825:"A novel kind of tumor type-characteristic junction: plakophilin-2 as a major protein of adherens junctions in cardiac myxomata"
2538:"Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes"
5543:
1878:
1857:
1597:
1593:
1589:
1573:
1482:
5812:
5655:
4382:
3510:"Comprehensive desmosome mutation analysis in north americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy"
219:
194:
2031:
1874:
4289:"Clinical features of arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in plakophilin-2"
6691:
6245:
2001:
3254:
van
Tintelen JP, Hauer RN (July 2009). "Cardiomyopathies: New test for arrhythmogenic right ventricular cardiomyopathy".
3084:"Plakophilin-2 mutations are the major determinant of familial arrhythmogenic right ventricular dysplasia/cardiomyopathy"
1853:
4324:"Penetrance of mutations in plakophilin-2 among families with arrhythmogenic right ventricular dysplasia/cardiomyopathy"
3172:
Kirchner F, Schuetz A, Boldt LH, Martens K, Dittmar G, Haverkamp W, Thierfelder L, Heinemann U, Gerull B (August 2012).
136:
2204:"Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2"
4952:
3866:"Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque"
1750:
4114:
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004).
1461:
There are data to support molecular crosstalk between plakophilin-2 and proteins involved in mechanical junctions in
3174:"Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations"
333:
232:
6423:
3727:"Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype"
3125:"Arrhythmogenic right ventricular cardiomyopathy plakophilin-2 mutations disrupt desmosome assembly and stability"
1572:
mutations may be unveiled with pharmacological challenge. Evidence has also shown that plakophilin-2 binds to the
2919:"Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy"
326:
225:
3776:"Desmosomes and the sodium channel complex: implications for arrhythmogenic cardiomyopathy and Brugada syndrome"
2302:
Jefferson JJ, Leung CL, Liem RK (July 2004). "Plakins: goliaths that link cell junctions and the cytoskeleton".
6656:
3823:
Rickelt S, Rizzo S, Doerflinger Y, Zentgraf H, Basso C, Gerosa G, Thiene G, Moll R, Franke WW (November 2010).
977:
144:
4365:
GeneReviews/NCBI/NIH/UW entry on
Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, Autosomal Dominant
3637:"Skin-heart connection: what can the epidermis tell us about the myocardium in arrhythmogenic cardiomyopathy?"
2960:"Clinical expression of plakophilin-2 mutations in familial arrhythmogenic right ventricular cardiomyopathy"
1929:"Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque"
1830:
1621:
1520:
propagation. It has also been demonstrated that plakophilin-2 associates with an important component of the
958:
2345:
Bass-Zubek AE, Hobbs RP, Amargo EV, Garcia NJ, Hsieh SN, Chen X, Wahl JK, Denning MF, Green KJ (May 2008).
2779:"Identification of a PKP2 gene deletion in a family with arrhythmogenic right ventricular cardiomyopathy"
5075:
4429:
3461:"Mechanisms of disease: molecular genetics of arrhythmogenic right ventricular dysplasia/cardiomyopathy"
1350:
208:
2536:
Sato PY, Musa H, Coombs W, Guerrero-Serna G, Patiño GA, Taffet SM, Isom LL, Delmar M (September 2009).
2443:
Godsel LM, Dubash AD, Bass-Zubek AE, Amargo EV, Klessner JL, Hobbs RP, Chen X, Green KJ (August 2010).
4073:"Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate"
3678:"Titin and desmosomal genes in the natural history of arrhythmogenic right ventricular cardiomyopathy"
5344:
4170:
2691:"Heterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated disk"
2215:
1679:
1625:
1505:
1254:
33:
123:
6651:
5284:
2639:"Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency"
1419:
disarray and cardiac wall rupture. Further studies demonstrated that plakophilin-2 coordinate with
1098:
1051:
1272:). A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.
5104:
4734:
4196:
4030:
3441:
3279:
3154:
2992:
2394:
Grossmann KS, Grund C, Huelsken J, Behrend M, Erdmann B, Franke WW, Birchmeier W (October 2004).
2347:"Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly"
2327:
168:
2590:"Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc"
2202:
Mertens C, Hofmann I, Wang Z, Teichmann M, Sepehri Chong S, Schnölzer M, Franke WW (July 2001).
1123:
1102:
1072:
1047:
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Agullo-Pascual E, Reid DA, Keegan S, Sidhu M, Fenyö D, Rothenberg E, Delmar M (November 2013).
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1671:
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1435:
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1234:
116:
60:
6225:
4370:
OMIM entries on Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, Autosomal Dominant
1553:
amplitude, as well as a shift in gating and kinetics; pharmacological challenge also induced
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6157:
6142:
6137:
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2311:
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2233:
2223:
2174:
2118:
2077:
2069:
1948:
1940:
1737:, suggesting that plakophilin-2 may serve as a valuable marker in the clinical diagnosis of
1719:
1565:
1557:
1517:
1455:
1322:
Plakophilin 2 functions to link cadherins to intermediate filaments in the cytoskeleton. In
1284:
1276:
578:
571:
413:
344:
288:
243:
6367:
6362:
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6352:
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5757:
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4652:
4632:
4536:
4516:
2588:
Sato PY, Coombs W, Lin X, Nekrasova O, Green KJ, Isom LL, Taffet SM, Delmar M (July 2011).
1411:
granular aggregates around embryonic day 10.5-11. Additional malformation included reduced
641:
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
6592:
5206:
5056:
4939:
4759:
388:
164:
4210:"Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer"
2494:"Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells"
4174:
2219:
6555:
6418:
5115:
4946:
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4270:
4245:
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6614:
5579:
5449:
5398:
5348:
5288:
5210:
5178:
5119:
4905:
4424:
2396:"Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation"
2238:
2203:
1683:
1462:
1323:
607:
4034:
3653:
3636:
3525:
3445:
3283:
3190:
3173:
3158:
2445:"Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA"
2331:
148:
6463:
5518:
5273:
4817:
4409:
4200:
1546:
1470:
1431:
1416:
1376:
and plakophilin-2. Plakophilin is necessary for normal localization and content of
1222:
406:
185:
6435:
6413:
3693:
3375:
Sen-Chowdhry S, Syrris P, Ward D, Asimaki A, Sevdalis E, McKenna WJ (April 2007).
2996:
2826:
Zhang M, Tavora F, Oliveira JB, Li L, Franco M, Fowler D, Zhao Z, Burke A (2012).
2605:
2553:
2510:
2493:
1612:
have been associated with, have been shown to cause, and are considered common in
1600:
and mediates crosstalk between intercellular junctions and membrane excitability.
3429:
3059:
2279:
2262:
172:
6609:
6560:
6430:
6320:
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5094:
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3353:
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2122:
1914:
National Center for Biotechnology Information, U.S. National Library of Medicine
1896:
National Center for Biotechnology Information, U.S. National Library of Medicine
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1404:
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1307:
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3214:
2754:
2208:
Proceedings of the National Academy of Sciences of the United States of America
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1311:
1292:
1288:
1269:
1265:
305:
202:
152:
3267:
2959:
2844:
2827:
1647:
mutations result in instability of the plakophilin-2 protein due to enhanced
1639:. These mutations in general appear to disrupt the assembly and stability of
6490:
6485:
6480:
6440:
6278:
6273:
6268:
5626:
5606:
5261:
5256:
5236:
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5125:
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Oxford EM, Musa H, Maass K, Coombs W, Taffet SM, Delmar M (September 2007).
2460:
1705:
1686:
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1447:
1439:
1408:
1385:
1381:
1339:
1327:
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2429:
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2323:
2288:
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2228:
2188:
2179:
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2130:
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1944:
773:
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
3938:
3476:
2411:
2362:
1962:
1564:
crosstalk with sodium channels in the heart, and suggest that the risk of
1187:
1182:
6604:
6565:
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6195:
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4982:
4844:
3881:
2794:
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1365:
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1264:
have been identified. The first has a molecular weight of 97.4 kDa (881
758:
cell communication by electrical coupling involved in cardiac conduction
6631:
6585:
6475:
6405:
6374:
6304:
6299:
6263:
6258:
6253:
6220:
6190:
6185:
6180:
6175:
5860:
5792:
5787:
5782:
5777:
5772:
5664:
5601:
5089:
5034:
4975:
4958:
4919:
4405:
4261:
4131:
1648:
1592:
channel current density was ~40% smaller and regional heterogeneity of
1493:
1342:
1296:
1280:
1203:
989:
944:
4018:
1689:
has shown to be a highly sensitive and specific diagnostic indicator.
93:
89:
6550:
6532:
6527:
6522:
6517:
6507:
6342:
6235:
6230:
6215:
6210:
6122:
6068:
6033:
6008:
6003:
5998:
5993:
5983:
5978:
5968:
5953:
5948:
5830:
5825:
5820:
5732:
5722:
5702:
5687:
5682:
5677:
5672:
5538:
5309:
5304:
5061:
4727:
4722:
4712:
4490:
1811:
1763:
1738:
1734:
1730:
1667:
1577:
1155:
899:
2315:
2058:"Plakophilins: multifunctional scaffolds for adhesion and signaling"
17:
2935:
2918:
1596:
channels was altered, suggesting that plakophilin-2 interacts with
6575:
6347:
6330:
6167:
6162:
6152:
6147:
6112:
6102:
6092:
6077:
6058:
6048:
6043:
6028:
6023:
6018:
6013:
5988:
5973:
5963:
5958:
5943:
5938:
5918:
5913:
5908:
5903:
5898:
5893:
5888:
5883:
5878:
5873:
5868:
5840:
5835:
5802:
5797:
5767:
5762:
5742:
5737:
5717:
5707:
5622:
5500:
5495:
5490:
5485:
5480:
5475:
5470:
5465:
5460:
5455:
5439:
5434:
5429:
5424:
5419:
5414:
5409:
5404:
5379:
5374:
5369:
5364:
5359:
5354:
5334:
5329:
5324:
5319:
5299:
5294:
5004:
4934:
4883:
4880:
4877:
4869:
4858:
4855:
4852:
4837:
4832:
4827:
4822:
4794:
4784:
4769:
4702:
4692:
4672:
4647:
4642:
4627:
4617:
4612:
4607:
4602:
4597:
4592:
4577:
4531:
4526:
4521:
4511:
4506:
4501:
4480:
4475:
4470:
4460:
4447:
1817:
1533:
1486:
1428:
862:
858:
6676:
6671:
6666:
6626:
6597:
6512:
6389:
6384:
6379:
6283:
5933:
5928:
5923:
5850:
5845:
5712:
5594:
5589:
5584:
5044:
5039:
4997:
4910:
4900:
4895:
4789:
4779:
4774:
4764:
4754:
4749:
4744:
4739:
4662:
4587:
4582:
4572:
4567:
4562:
4557:
4552:
4547:
1799:
1787:
1781:
1775:
1769:
1757:
1636:
1537:
1529:
1525:
1501:
1490:
1478:
1466:
1424:
1302:
Plakophilin 2 localizes to cell desmosomes and nuclei and binds
1261:
1210:
140:
4378:
2161:
Chen X, Bonne S, Hatzfeld M, van Roy F, Green KJ (March 2002).
587:
4208:
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005).
813:
regulation of ventricular cardiac muscle cell action potential
2056:
Bass-Zubek AE, Godsel LM, Delmar M, Green KJ (October 2009).
1283:
family. Plakophilin proteins contain nine central, conserved
4116:"Functional Proteomics Mapping of a Human Signaling Pathway"
1628:. It is estimated that 70% of all mutations associated with
768:
cardiac muscle cell action potential involved in contraction
1696:
is currently under intense investigation to understand the
1434:
rearrangement in order to properly couple the assembly of
1295:
domains. Alternately spliced transcripts encoding protein
4244:
Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006).
1733:
tumors analyzed, and absent in patients with noncardiac
1516:
alters sodium current properties as well as velocity of
396:
2028:
Cardiac Organellar Protein Atlas Knowledgebase (COPaKB)
2024:"Protein sequence of human PKP2 (Uniprot ID: Q99959-2)"
1998:
Cardiac Organellar Protein Atlas Knowledgebase (COPaKB)
1616:, which is characterized by fibrofatty replacement of
1349:, is the core constituent of the plaque which anchors
1268:) and the second of molecular weight of 92.7 kDa (837
1994:"Protein sequence of human PKP2 (Uniprot ID: Q99959)"
561:
32:"PKP2" redirects here. For the 2015 Indian film, see
4071:
Müller J, Ritt DA, Copeland TD, Morrison DK (2003).
6644:
6543:
6449:
6404:
6313:
6292:
6244:
6067:
5859:
5811:
5663:
5649:
5615:
5562:
5531:
5511:
5390:
5272:
5103:
5085:
5074:
5017:
4810:
4489:
4446:
4437:
4423:
4416:
1116:
1091:
1065:
1040:
2267:Biochimica et Biophysica Acta (BBA) - Biomembranes
1870:
1868:
1866:
1849:
1847:
1845:
778:cell-cell signaling involved in cardiac conduction
2103:
2101:
2051:
2049:
1560:. These findings further support the notion that
1384:, which may in part be due to the recruitment of
343:
242:
3465:Nature Clinical Practice Cardiovascular Medicine
1496:, as well as a decrease in coupling of adjacent
1442:precursors in newly formed cell-cell junctions.
763:ventricular cardiac muscle cell action potential
3123:Hall C, Li S, Li H, Creason V, Wahl JK (2009).
2263:"Desmosome structure, composition and function"
1694:arrhythmogenic right ventricular cardiomyopathy
1664:arrhythmogenic right ventricular cardiomyopathy
1630:arrhythmogenic right ventricular cardiomyopathy
1614:arrhythmogenic right ventricular cardiomyopathy
1243:arrhythmogenic right ventricular cardiomyopathy
783:ventricular cardiac muscle tissue morphogenesis
27:Protein-coding gene in the species Homo sapiens
1875:GRCm38: Ensembl release 89: ENSMUSG00000041957
1708:proteins, in disease progression and outcome.
1643:. Mechanistic studies have shown that certain
1536:downregulation mislocalized plakophilin-2 and
808:regulation of heart rate by cardiac conduction
4390:
1927:Mertens C, Kuhn C, Franke WW (January 1997).
1504:and plakophilin-2 are components in the same
1489:leads to a decrease in and redistribution of
8:
2684:
2682:
2583:
2581:
2531:
2529:
2156:
2154:
2152:
2150:
2148:
2146:
2144:
2142:
2140:
1485:. Decreased expression of plakophilin-2 via
1854:GRCh38: Ensembl release 89: ENSG00000057294
1704:mutations, as well as other genes encoding
1674:wall motion abnormalities, and ventricular
803:positive regulation of sodium ion transport
5660:
5100:
5082:
4443:
4434:
4420:
4397:
4383:
4375:
1714:mutations were also found to coexist with
873:
603:
384:
283:
180:
78:
4339:
4304:
4269:
4225:
4182:
4139:
4096:
3889:
3840:
3799:
3750:
3701:
3652:
3611:
3533:
3484:
3459:Awad MM, Calkins H, Judge DP (May 2008).
3392:
3315:
3230:
3189:
3140:
3099:
2978:
2934:
2892:
2843:
2802:
2716:
2706:
2662:
2613:
2561:
2509:
2468:
2419:
2370:
2278:
2237:
2227:
2178:
2081:
1952:
1725:Additionally, plakophilin-2 was found in
1692:Clinical and genetic characterization of
1213:. Plakophilin 2 is expressed in skin and
1974:
1972:
2109:ventricular dysplasia/cardiomyopathy".
1841:
833:protein localization to plasma membrane
520:cardiac muscle tissue of left ventricle
1549:null mutation, which showed decreased
38:
2304:Nature Reviews Molecular Cell Biology
1508:. Plakophilin-2 also associates with
753:intermediate filament bundle assembly
458:cardiac muscle tissue of right atrium
348:
309:
304:
247:
206:
201:
7:
6719:Armadillo-repeat-containing proteins
3641:Circulation: Cardiovascular Genetics
3514:Circulation: Cardiovascular Genetics
3178:Circulation: Cardiovascular Genetics
2743:European Journal of Medical Genetics
1512:, and knockdown of plakophilin-2 in
818:maintenance of animal organ identity
3048:International Journal of Cardiology
2695:The Journal of Biological Chemistry
2167:The Journal of Biological Chemistry
1473:; the voltage-gated sodium channel
1310:, and the desmosomal cadherins via
732:messenger ribonucleoprotein complex
3989:10.1046/j.1432-0436.1999.6450291.x
3960:10.1046/j.1432-0436.1999.6450277.x
2783:European Journal of Human Genetics
2261:Garrod D, Chidgey M (March 2008).
1654:Specific and sensitive markers of
1113:
1088:
1062:
1037:
1013:
994:
968:
949:
923:
904:
566:
484:
422:
401:
25:
4306:10.1161/CIRCULATIONAHA.105.568642
3780:Trends in Cardiovascular Medicine
3774:Cerrone M, Delmar M (July 2014).
3743:10.1161/CIRCULATIONAHA.113.003077
3394:10.1161/CIRCULATIONAHA.106.660241
3317:10.1161/CIRCULATIONAHA.110.988287
3129:Cell Communication & Adhesion
3101:10.1161/CIRCULATIONAHA.105.609719
2980:10.1161/CIRCULATIONAHA.105.561654
1980:"Entrez Gene: PKP2 plakophilin 2"
1469:, the major component of cardiac
1423:is required to properly localize
1275:Plakophilin-2 is a member of the
1221:to intermediate filaments in the
1206:that in humans is encoded by the
631:transmembrane transporter binding
621:sodium channel regulator activity
5025:Wiskott–Aldrich syndrome protein
1682:analysis of proteins comprising
1666:have been identified to include
1403:, including the dissociation of
1241:have been shown to be causal in
577:
570:
332:
325:
319:
296:
231:
224:
218:
193:
6246:Microtubule organising proteins
3654:10.1161/CIRCGENETICS.114.000647
3526:10.1161/CIRCGENETICS.109.858217
3191:10.1161/CIRCGENETICS.111.961854
2062:Current Opinion in Cell Biology
677:integral component of membrane
588:More reference expression data
550:More reference expression data
1:
6293:Microtubule severing proteins
3694:10.1136/jmedgenet-2014-102591
3418:Current Opinion in Cardiology
2606:10.1161/CIRCRESAHA.111.247023
2554:10.1161/CIRCRESAHA.109.201418
2511:10.1161/CIRCRESAHA.107.154252
2449:Molecular Biology of the Cell
1477:and its interacting subunit,
1217:, where it functions to link
848:adherens junction maintenance
626:intermediate filament binding
317:
216:
6714:Genes on human chromosome 12
4953:actin depolymerizing factors
3430:10.1097/HCO.0b013e3280d942c4
3060:10.1016/j.ijcard.2007.03.137
2280:10.1016/j.bbamem.2007.07.014
1326:, plakophilin-2 is found at
1229:, plakophilin-2 is found in
446:myocardium of left ventricle
6431:Plakoglobin (gamma catenin)
3682:Journal of Medical Genetics
3572:10.1016/j.hrthm.2009.09.070
3558:cardiomyopathy/dysplasia".
3354:10.1016/j.hrthm.2011.03.015
3025:10.1016/j.hrthm.2006.04.028
2400:The Journal of Cell Biology
2351:The Journal of Cell Biology
2123:10.1016/j.hrthm.2014.07.041
1500:. Studies also showed that
843:cell-cell junction assembly
6735:
4341:10.1016/j.jacc.2006.06.045
4227:10.1074/mcp.M500021-MCP200
3842:10.1038/modpathol.2010.138
3594:B, Charron P (June 2010).
3256:Nature Reviews. Cardiology
2755:10.1016/j.ejmg.2015.02.009
1233:structures located within
646:molecular adaptor activity
504:superior surface of tongue
474:mucosa of transverse colon
31:
6687:
4184:10.1016/j.cub.2004.07.051
3792:10.1016/j.tcm.2014.02.001
3142:10.1080/15419060903009329
2885:10.1007/s12471-010-0839-5
2873:Netherlands Heart Journal
2074:10.1016/j.ceb.2009.07.002
1910:"Mouse PubMed Reference:"
1892:"Human PubMed Reference:"
1186:
1181:
1177:
1170:
1154:
1135:
1120:
1095:
1084:
1069:
1044:
1033:
1020:
1016:
1001:
997:
988:
975:
971:
956:
952:
943:
930:
926:
911:
907:
898:
883:
876:
872:
856:
606:
602:
585:
569:
560:
547:
496:
487:
434:
425:
395:
387:
383:
366:
353:
316:
295:
286:
282:
265:
252:
215:
192:
183:
179:
134:
131:
121:
114:
109:
86:
81:
64:
59:
54:
50:
46:
41:
6657:Prokaryotic cytoskeleton
3268:10.1038/nrcardio.2009.97
3232:10.1093/eurheartj/ehl184
2845:10.1253/circj.cj-11-0747
1438:to the translocation of
1338:membranes together. The
1148:Chr 16: 16.03 – 16.09 Mb
656:protein kinase C binding
4056:10.1242/jcs.113.13.2471
3870:Cardiovascular Research
3613:10.1093/europace/euq104
2708:10.1074/jbc.M112.412122
2643:Cardiovascular Research
2461:10.1091/mbc.E10-02-0131
1831:Skin fragility syndrome
1749:PKP2 has been shown to
1651:-mediated degradation.
1622:ventricular tachycardia
1584:from haploinsufficient
1141:Chr 12: 32.79 – 32.9 Mb
516:myocardium of ventricle
466:mucosa of sigmoid colon
3931:10.1006/geno.1998.5398
3635:Gerull B (June 2014).
3219:European Heart Journal
2229:10.1073/pnas.141219498
2180:10.1074/jbc.M108765200
1945:10.1083/jcb.135.4.1009
1716:sodium channelopathies
1386:protein kinase C alpha
1351:intermediate filaments
1334:, which link adjacent
1299:have been identified.
512:atrioventricular valve
127:, ARVD9, plakophilin 2
5277:(hard alpha-keratins)
5108:(soft alpha-keratins)
4214:Mol. Cell. Proteomics
4007:Cytogenet. Cell Genet
3477:10.1038/ncpcardio1182
2412:10.1083/jcb.200402096
2363:10.1083/jcb.200712133
1662:mutation carriers in
1604:Clinical significance
717:intermediate filament
651:alpha-catenin binding
311:Chromosome 16 (mouse)
209:Chromosome 12 (human)
6692:cytoskeletal defects
6652:Major sperm proteins
4328:J. Am. Coll. Cardiol
4089:10.1093/emboj/cdg426
2795:10.1038/ejhg.2013.39
2594:Circulation Research
2542:Circulation Research
2498:Circulation Research
1626:sudden cardiac death
1506:biomolecular complex
82:List of PDB id codes
55:Available structures
34:Pyaar Ka Punchnama 2
5105:Epithelial keratins
4175:2004CBio...14.1436J
2832:Circulation Journal
2220:2001PNAS...98.7795M
1680:immunohistochemical
1287:domains flanked by
524:endocardial cushion
4262:10.1101/gr.4039406
4132:10.1101/gr.2334104
3882:10.1093/cvr/cvt191
2655:10.1093/cvr/cvs218
1727:adherens junctions
1670:inversions, right
1448:desmosomal plaques
1436:adherens junctions
1361:and indirectly to
1332:intercalated discs
1330:structures within
1235:intercalated discs
978:ENSMUSG00000041957
838:cell-cell adhesion
793:desmosome assembly
746:Biological process
727:cornified envelope
687:cell-cell junction
670:Cellular component
614:Molecular function
536:epithelium of lens
450:right uterine tube
6699:
6698:
6640:
6639:
6400:
6399:
5645:
5644:
5527:
5526:
5070:
5069:
5013:
5012:
4019:10.1159/000015540
1718:in patients with
1576:channel subunit,
1568:in patients with
1407:and formation of
1372:, facilitated by
1197:
1196:
1193:
1192:
1166:
1165:
1131:
1130:
1110:
1109:
1080:
1079:
1059:
1058:
1029:
1028:
1010:
1009:
984:
983:
965:
964:
939:
938:
920:
919:
868:
867:
788:heart development
692:adherens junction
682:intercalated disc
598:
597:
594:
593:
556:
555:
543:
542:
481:
480:
379:
378:
278:
277:
105:
104:
101:
100:
65:Ortholog search:
16:(Redirected from
6726:
5661:
5101:
5083:
4444:
4435:
4421:
4399:
4392:
4385:
4376:
4353:
4343:
4318:
4308:
4283:
4273:
4239:
4229:
4204:
4186:
4153:
4143:
4110:
4100:
4067:
4038:
4000:
3971:
3942:
3904:
3903:
3893:
3861:
3855:
3854:
3844:
3829:Modern Pathology
3820:
3814:
3813:
3803:
3771:
3765:
3764:
3754:
3737:(10): 1092–103.
3722:
3716:
3715:
3705:
3673:
3667:
3666:
3656:
3632:
3626:
3625:
3615:
3590:
3584:
3583:
3554:
3548:
3547:
3537:
3505:
3499:
3498:
3488:
3456:
3450:
3449:
3413:
3407:
3406:
3396:
3372:
3366:
3365:
3336:
3330:
3329:
3319:
3310:(23): 2690–700.
3294:
3288:
3287:
3251:
3245:
3244:
3234:
3210:
3204:
3203:
3193:
3169:
3163:
3162:
3144:
3120:
3114:
3113:
3103:
3078:
3072:
3071:
3043:
3037:
3036:
3007:
3001:
3000:
2982:
2964:
2955:
2949:
2948:
2938:
2913:
2907:
2906:
2896:
2864:
2858:
2857:
2847:
2823:
2817:
2816:
2806:
2773:
2767:
2766:
2737:
2731:
2730:
2720:
2710:
2701:(49): 41258–67.
2686:
2677:
2676:
2666:
2634:
2628:
2627:
2617:
2585:
2576:
2575:
2565:
2533:
2524:
2523:
2513:
2489:
2483:
2482:
2472:
2440:
2434:
2433:
2423:
2391:
2385:
2384:
2374:
2342:
2336:
2335:
2299:
2293:
2292:
2282:
2258:
2252:
2251:
2241:
2231:
2214:(14): 7795–800.
2199:
2193:
2192:
2182:
2173:(12): 10512–22.
2158:
2135:
2134:
2105:
2096:
2095:
2085:
2053:
2044:
2043:
2041:
2039:
2030:. Archived from
2020:
2014:
2013:
2011:
2009:
2000:. Archived from
1990:
1984:
1983:
1976:
1967:
1966:
1956:
1924:
1918:
1917:
1906:
1900:
1899:
1888:
1882:
1872:
1861:
1851:
1739:cardiac myxomata
1731:cardiac myxomata
1720:Brugada syndrome
1700:associated with
1678:. Additionally,
1518:action potential
1285:armadillo repeat
1279:and plakophilin
1277:armadillo repeat
1179:
1178:
1150:
1143:
1126:
1114:
1105:
1089:
1085:RefSeq (protein)
1075:
1063:
1054:
1038:
1014:
995:
969:
950:
924:
905:
874:
661:cadherin binding
604:
590:
581:
574:
567:
552:
500:Ileal epithelium
492:
490:Top expressed in
485:
430:
428:Top expressed in
423:
402:
385:
375:
362:
351:
336:
329:
323:
312:
300:
284:
274:
261:
250:
235:
228:
222:
211:
197:
181:
175:
173:PKP2 - orthologs
126:
119:
96:
79:
73:
52:
51:
39:
21:
6734:
6733:
6729:
6728:
6727:
6725:
6724:
6723:
6704:
6703:
6700:
6695:
6683:
6636:
6539:
6445:
6396:
6309:
6288:
6240:
6063:
5855:
5807:
5653:
5641:
5611:
5558:
5523:
5507:
5391:Ungrouped alpha
5386:
5276:
5268:
5107:
5093:
5087:
5077:
5066:
5009:
4806:
4485:
4427:
4412:
4403:
4361:
4356:
4321:
4286:
4242:
4207:
4169:(16): 1436–50.
4156:
4113:
4083:(17): 4431–42.
4070:
4050:(13): 2471–83.
4041:
4003:
3977:Differentiation
3974:
3948:Differentiation
3945:
3916:
3912:
3910:Further reading
3907:
3863:
3862:
3858:
3835:(11): 1429–37.
3822:
3821:
3817:
3773:
3772:
3768:
3724:
3723:
3719:
3675:
3674:
3670:
3634:
3633:
3629:
3592:
3591:
3587:
3556:
3555:
3551:
3507:
3506:
3502:
3458:
3457:
3453:
3415:
3414:
3410:
3387:(13): 1710–20.
3374:
3373:
3369:
3338:
3337:
3333:
3296:
3295:
3291:
3253:
3252:
3248:
3225:(18): 2208–16.
3212:
3211:
3207:
3171:
3170:
3166:
3122:
3121:
3117:
3080:
3079:
3075:
3045:
3044:
3040:
3009:
3008:
3004:
2962:
2957:
2956:
2952:
2923:Nature Genetics
2915:
2914:
2910:
2866:
2865:
2861:
2825:
2824:
2820:
2789:(11): 1226–31.
2775:
2774:
2770:
2739:
2738:
2734:
2688:
2687:
2680:
2636:
2635:
2631:
2587:
2586:
2579:
2535:
2534:
2527:
2491:
2490:
2486:
2455:(16): 2844–59.
2442:
2441:
2437:
2393:
2392:
2388:
2344:
2343:
2339:
2316:10.1038/nrm1425
2301:
2300:
2296:
2260:
2259:
2255:
2201:
2200:
2196:
2160:
2159:
2138:
2107:
2106:
2099:
2055:
2054:
2047:
2037:
2035:
2034:on 12 July 2015
2022:
2021:
2017:
2007:
2005:
2004:on 12 July 2015
1992:
1991:
1987:
1978:
1977:
1970:
1926:
1925:
1921:
1908:
1907:
1903:
1890:
1889:
1885:
1873:
1864:
1852:
1843:
1839:
1827:
1747:
1632:are within the
1606:
1320:
1255:splice variants
1251:
1237:. Mutations in
1188:View/Edit Mouse
1183:View/Edit Human
1146:
1139:
1136:Location (UCSC)
1122:
1101:
1097:
1071:
1050:
1046:
959:ENSG00000057294
852:
741:
697:plasma membrane
665:
636:protein binding
586:
576:
575:
548:
539:
534:
530:
526:
522:
518:
514:
510:
506:
502:
488:
477:
472:
468:
464:
462:mucosa of colon
460:
456:
452:
448:
444:
440:
438:right ventricle
426:
370:
357:
349:
339:
338:
337:
330:
310:
287:Gene location (
269:
256:
248:
238:
237:
236:
229:
207:
184:Gene location (
135:
122:
115:
88:
66:
37:
28:
23:
22:
15:
12:
11:
5:
6732:
6730:
6722:
6721:
6716:
6706:
6705:
6697:
6696:
6688:
6685:
6684:
6682:
6681:
6680:
6679:
6674:
6669:
6664:
6654:
6648:
6646:
6642:
6641:
6638:
6637:
6635:
6634:
6629:
6624:
6623:
6622:
6617:
6607:
6602:
6601:
6600:
6590:
6589:
6588:
6583:
6578:
6573:
6568:
6563:
6558:
6556:Corneodesmosin
6547:
6545:
6541:
6540:
6538:
6537:
6536:
6535:
6530:
6525:
6520:
6515:
6510:
6505:
6495:
6494:
6493:
6488:
6483:
6473:
6468:
6467:
6466:
6455:
6453:
6447:
6446:
6444:
6443:
6438:
6433:
6428:
6427:
6426:
6416:
6410:
6408:
6402:
6401:
6398:
6397:
6395:
6394:
6393:
6392:
6387:
6382:
6372:
6371:
6370:
6365:
6360:
6355:
6350:
6340:
6335:
6334:
6333:
6323:
6317:
6315:
6311:
6310:
6308:
6307:
6302:
6296:
6294:
6290:
6289:
6287:
6286:
6281:
6276:
6271:
6266:
6261:
6256:
6250:
6248:
6242:
6241:
6239:
6238:
6233:
6228:
6223:
6218:
6213:
6208:
6203:
6198:
6193:
6188:
6183:
6178:
6171:
6170:
6165:
6160:
6155:
6150:
6145:
6140:
6135:
6130:
6125:
6120:
6115:
6110:
6105:
6100:
6095:
6090:
6085:
6080:
6073:
6071:
6065:
6064:
6062:
6061:
6056:
6051:
6046:
6041:
6036:
6031:
6026:
6021:
6016:
6011:
6006:
6001:
5996:
5991:
5986:
5981:
5976:
5971:
5966:
5961:
5956:
5951:
5946:
5941:
5936:
5931:
5926:
5921:
5916:
5911:
5906:
5901:
5896:
5891:
5886:
5881:
5876:
5871:
5865:
5863:
5857:
5856:
5854:
5853:
5848:
5843:
5838:
5833:
5828:
5823:
5817:
5815:
5809:
5808:
5806:
5805:
5800:
5795:
5790:
5785:
5780:
5775:
5770:
5765:
5760:
5755:
5750:
5745:
5740:
5735:
5730:
5725:
5720:
5715:
5710:
5705:
5700:
5695:
5690:
5685:
5680:
5675:
5669:
5667:
5658:
5647:
5646:
5643:
5642:
5640:
5639:
5634:
5629:
5623:Nuclear lamins
5619:
5617:
5613:
5612:
5610:
5609:
5604:
5599:
5598:
5597:
5592:
5587:
5577:
5572:
5566:
5564:
5560:
5559:
5557:
5556:
5551:
5546:
5541:
5535:
5533:
5529:
5528:
5525:
5524:
5522:
5521:
5515:
5513:
5509:
5508:
5506:
5505:
5504:
5503:
5498:
5493:
5488:
5483:
5478:
5473:
5468:
5463:
5458:
5445:
5444:
5443:
5442:
5437:
5432:
5427:
5422:
5417:
5412:
5407:
5394:
5392:
5388:
5387:
5385:
5384:
5383:
5382:
5377:
5372:
5367:
5362:
5357:
5340:
5339:
5338:
5337:
5332:
5327:
5322:
5317:
5312:
5307:
5302:
5297:
5280:
5278:
5270:
5269:
5267:
5266:
5265:
5264:
5259:
5254:
5249:
5244:
5239:
5234:
5229:
5224:
5219:
5202:
5201:
5200:
5199:
5189:
5188:
5187:
5175:
5174:
5173:
5168:
5163:
5158:
5153:
5148:
5143:
5138:
5133:
5128:
5111:
5109:
5098:
5080:
5072:
5071:
5068:
5067:
5065:
5064:
5059:
5054:
5053:
5052:
5047:
5042:
5032:
5027:
5021:
5019:
5015:
5014:
5011:
5010:
5008:
5007:
5002:
5001:
5000:
4995:
4985:
4980:
4979:
4978:
4973:
4972:
4971:
4966:
4949:
4947:Arp2/3 complex
4944:
4943:
4942:
4937:
4932:
4927:
4916:
4915:
4914:
4913:
4908:
4903:
4898:
4888:
4887:
4886:
4872:
4861:
4842:
4841:
4840:
4835:
4830:
4825:
4814:
4812:
4808:
4807:
4805:
4804:
4803:
4802:
4797:
4792:
4787:
4782:
4777:
4772:
4767:
4762:
4757:
4752:
4747:
4742:
4732:
4731:
4730:
4725:
4717:
4716:
4715:
4707:
4706:
4705:
4697:
4696:
4695:
4690:
4682:
4681:
4680:
4675:
4667:
4666:
4665:
4657:
4656:
4655:
4650:
4645:
4637:
4636:
4635:
4630:
4622:
4621:
4620:
4615:
4610:
4605:
4600:
4595:
4590:
4585:
4580:
4575:
4570:
4565:
4560:
4555:
4550:
4542:
4541:
4540:
4534:
4529:
4524:
4519:
4514:
4509:
4504:
4495:
4493:
4487:
4486:
4484:
4483:
4478:
4473:
4468:
4463:
4458:
4452:
4450:
4441:
4432:
4425:Microfilaments
4418:
4414:
4413:
4404:
4402:
4401:
4394:
4387:
4379:
4373:
4372:
4367:
4360:
4359:External links
4357:
4355:
4354:
4334:(7): 1416–24.
4319:
4299:(13): 1641–9.
4284:
4240:
4205:
4154:
4126:(7): 1324–32.
4111:
4068:
4039:
4013:(3–4): 286–7.
4001:
3983:(5): 291–306.
3972:
3943:
3913:
3911:
3908:
3906:
3905:
3856:
3815:
3766:
3717:
3688:(10): 669–76.
3668:
3627:
3585:
3549:
3500:
3451:
3408:
3367:
3348:(8): 1214–21.
3331:
3289:
3246:
3205:
3164:
3135:(1–3): 15–27.
3115:
3094:(13): 1650–8.
3073:
3038:
3002:
2950:
2936:10.1038/ng1461
2929:(11): 1162–4.
2908:
2879:(12): 583–91.
2859:
2818:
2768:
2732:
2678:
2629:
2600:(2): 193–201.
2577:
2525:
2484:
2435:
2386:
2337:
2294:
2253:
2194:
2136:
2117:(11): 2010–7.
2097:
2045:
2015:
1985:
1968:
1939:(4): 1009–25.
1919:
1901:
1883:
1862:
1840:
1838:
1835:
1834:
1833:
1826:
1823:
1822:
1821:
1815:
1809:
1803:
1797:
1791:
1785:
1779:
1773:
1767:
1761:
1746:
1743:
1618:cardiomyocytes
1605:
1602:
1582:cardiomyocytes
1580:, and that in
1528:, and loss of
1514:cardiomyocytes
1498:cardiomyocytes
1463:cardiomyocytes
1401:cardiomyocytes
1324:cardiomyocytes
1319:
1316:
1250:
1247:
1227:cardiac muscle
1215:cardiac muscle
1195:
1194:
1191:
1190:
1185:
1175:
1174:
1168:
1167:
1164:
1163:
1161:
1159:
1152:
1151:
1144:
1137:
1133:
1132:
1129:
1128:
1118:
1117:
1111:
1108:
1107:
1093:
1092:
1086:
1082:
1081:
1078:
1077:
1067:
1066:
1060:
1057:
1056:
1042:
1041:
1035:
1031:
1030:
1027:
1026:
1018:
1017:
1011:
1008:
1007:
999:
998:
992:
986:
985:
982:
981:
973:
972:
966:
963:
962:
954:
953:
947:
941:
940:
937:
936:
928:
927:
921:
918:
917:
909:
908:
902:
896:
895:
890:
885:
881:
880:
870:
869:
866:
865:
854:
853:
851:
850:
845:
840:
835:
830:
825:
823:keratinization
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
749:
747:
743:
742:
740:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
673:
671:
667:
666:
664:
663:
658:
653:
648:
643:
638:
633:
628:
623:
617:
615:
611:
610:
600:
599:
596:
595:
592:
591:
583:
582:
564:
558:
557:
554:
553:
545:
544:
541:
540:
538:
537:
533:
529:
525:
521:
517:
513:
509:
505:
501:
497:
494:
493:
482:
479:
478:
476:
475:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
432:
431:
419:
418:
410:
399:
393:
392:
389:RNA expression
381:
380:
377:
376:
368:
364:
363:
355:
352:
347:
341:
340:
331:
324:
318:
314:
313:
308:
302:
301:
293:
292:
280:
279:
276:
275:
267:
263:
262:
254:
251:
246:
240:
239:
230:
223:
217:
213:
212:
205:
199:
198:
190:
189:
177:
176:
133:
129:
128:
120:
112:
111:
107:
106:
103:
102:
99:
98:
84:
83:
75:
74:
63:
57:
56:
48:
47:
44:
43:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6731:
6720:
6717:
6715:
6712:
6711:
6709:
6702:
6694:
6693:
6686:
6678:
6675:
6673:
6670:
6668:
6665:
6663:
6660:
6659:
6658:
6655:
6653:
6650:
6649:
6647:
6643:
6633:
6630:
6628:
6625:
6621:
6618:
6616:
6613:
6612:
6611:
6608:
6606:
6603:
6599:
6596:
6595:
6594:
6591:
6587:
6584:
6582:
6579:
6577:
6574:
6572:
6569:
6567:
6564:
6562:
6559:
6557:
6554:
6553:
6552:
6549:
6548:
6546:
6542:
6534:
6531:
6529:
6526:
6524:
6521:
6519:
6516:
6514:
6511:
6509:
6506:
6504:
6501:
6500:
6499:
6496:
6492:
6489:
6487:
6484:
6482:
6479:
6478:
6477:
6474:
6472:
6469:
6465:
6462:
6461:
6460:
6457:
6456:
6454:
6452:
6448:
6442:
6439:
6437:
6436:Delta catenin
6434:
6432:
6429:
6425:
6422:
6421:
6420:
6417:
6415:
6414:Alpha catenin
6412:
6411:
6409:
6407:
6403:
6391:
6388:
6386:
6383:
6381:
6378:
6377:
6376:
6373:
6369:
6366:
6364:
6361:
6359:
6356:
6354:
6351:
6349:
6346:
6345:
6344:
6341:
6339:
6336:
6332:
6329:
6328:
6327:
6324:
6322:
6319:
6318:
6316:
6312:
6306:
6303:
6301:
6298:
6297:
6295:
6291:
6285:
6282:
6280:
6277:
6275:
6272:
6270:
6267:
6265:
6262:
6260:
6257:
6255:
6252:
6251:
6249:
6247:
6243:
6237:
6234:
6232:
6229:
6227:
6224:
6222:
6219:
6217:
6214:
6212:
6209:
6207:
6204:
6202:
6199:
6197:
6194:
6192:
6189:
6187:
6184:
6182:
6179:
6177:
6174:cytoplasmic:
6173:
6172:
6169:
6166:
6164:
6161:
6159:
6156:
6154:
6151:
6149:
6146:
6144:
6141:
6139:
6136:
6134:
6131:
6129:
6126:
6124:
6121:
6119:
6116:
6114:
6111:
6109:
6106:
6104:
6101:
6099:
6096:
6094:
6091:
6089:
6086:
6084:
6081:
6079:
6075:
6074:
6072:
6070:
6066:
6060:
6057:
6055:
6052:
6050:
6047:
6045:
6042:
6040:
6037:
6035:
6032:
6030:
6027:
6025:
6022:
6020:
6017:
6015:
6012:
6010:
6007:
6005:
6002:
6000:
5997:
5995:
5992:
5990:
5987:
5985:
5982:
5980:
5977:
5975:
5972:
5970:
5967:
5965:
5962:
5960:
5957:
5955:
5952:
5950:
5947:
5945:
5942:
5940:
5937:
5935:
5932:
5930:
5927:
5925:
5922:
5920:
5917:
5915:
5912:
5910:
5907:
5905:
5902:
5900:
5897:
5895:
5892:
5890:
5887:
5885:
5882:
5880:
5877:
5875:
5872:
5870:
5867:
5866:
5864:
5862:
5858:
5852:
5849:
5847:
5844:
5842:
5839:
5837:
5834:
5832:
5829:
5827:
5824:
5822:
5819:
5818:
5816:
5814:
5810:
5804:
5801:
5799:
5796:
5794:
5791:
5789:
5786:
5784:
5781:
5779:
5776:
5774:
5771:
5769:
5766:
5764:
5761:
5759:
5756:
5754:
5751:
5749:
5746:
5744:
5741:
5739:
5736:
5734:
5731:
5729:
5726:
5724:
5721:
5719:
5716:
5714:
5711:
5709:
5706:
5704:
5701:
5699:
5696:
5694:
5691:
5689:
5686:
5684:
5681:
5679:
5676:
5674:
5671:
5670:
5668:
5666:
5662:
5659:
5657:
5652:
5648:
5638:
5635:
5633:
5630:
5628:
5624:
5621:
5620:
5618:
5614:
5608:
5605:
5603:
5600:
5596:
5593:
5591:
5588:
5586:
5583:
5582:
5581:
5580:Neurofilament
5578:
5576:
5573:
5571:
5568:
5567:
5565:
5561:
5555:
5552:
5550:
5547:
5545:
5542:
5540:
5537:
5536:
5534:
5530:
5520:
5517:
5516:
5514:
5510:
5502:
5499:
5497:
5494:
5492:
5489:
5487:
5484:
5482:
5479:
5477:
5474:
5472:
5469:
5467:
5464:
5462:
5459:
5457:
5454:
5453:
5452:
5451:
5450:chromosome 12
5447:
5446:
5441:
5438:
5436:
5433:
5431:
5428:
5426:
5423:
5421:
5418:
5416:
5413:
5411:
5408:
5406:
5403:
5402:
5401:
5400:
5399:chromosome 17
5396:
5395:
5393:
5389:
5381:
5378:
5376:
5373:
5371:
5368:
5366:
5363:
5361:
5358:
5356:
5353:
5352:
5351:
5350:
5349:chromosome 12
5346:
5342:
5341:
5336:
5333:
5331:
5328:
5326:
5323:
5321:
5318:
5316:
5313:
5311:
5308:
5306:
5303:
5301:
5298:
5296:
5293:
5292:
5291:
5290:
5289:chromosome 17
5286:
5282:
5281:
5279:
5275:
5274:Hair keratins
5271:
5263:
5260:
5258:
5255:
5253:
5250:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5218:
5215:
5214:
5213:
5212:
5211:chromosome 12
5208:
5204:
5203:
5198:
5195:
5194:
5193:
5190:
5186:
5183:
5182:
5181:
5180:
5179:chromosome 12
5176:
5172:
5169:
5167:
5164:
5162:
5159:
5157:
5154:
5152:
5149:
5147:
5144:
5142:
5139:
5137:
5134:
5132:
5129:
5127:
5124:
5123:
5122:
5121:
5120:chromosome 17
5117:
5113:
5112:
5110:
5106:
5102:
5099:
5096:
5091:
5084:
5081:
5079:
5076:Intermediate
5073:
5063:
5060:
5058:
5055:
5051:
5048:
5046:
5043:
5041:
5038:
5037:
5036:
5033:
5031:
5028:
5026:
5023:
5022:
5020:
5016:
5006:
5003:
4999:
4996:
4994:
4991:
4990:
4989:
4986:
4984:
4981:
4977:
4974:
4970:
4967:
4965:
4962:
4961:
4960:
4957:
4956:
4955:
4954:
4950:
4948:
4945:
4941:
4938:
4936:
4933:
4931:
4928:
4926:
4923:
4922:
4921:
4918:
4917:
4912:
4909:
4907:
4904:
4902:
4899:
4897:
4894:
4893:
4892:
4889:
4885:
4882:
4879:
4876:
4873:
4871:
4868:
4865:
4862:
4860:
4857:
4854:
4851:
4848:
4847:
4846:
4843:
4839:
4836:
4834:
4831:
4829:
4826:
4824:
4821:
4820:
4819:
4816:
4815:
4813:
4809:
4801:
4798:
4796:
4793:
4791:
4788:
4786:
4783:
4781:
4778:
4776:
4773:
4771:
4768:
4766:
4763:
4761:
4758:
4756:
4753:
4751:
4748:
4746:
4743:
4741:
4738:
4737:
4736:
4733:
4729:
4726:
4724:
4721:
4720:
4718:
4714:
4711:
4710:
4708:
4704:
4701:
4700:
4698:
4694:
4691:
4689:
4686:
4685:
4683:
4679:
4676:
4674:
4671:
4670:
4668:
4664:
4661:
4660:
4658:
4654:
4651:
4649:
4646:
4644:
4641:
4640:
4638:
4634:
4631:
4629:
4626:
4625:
4623:
4619:
4616:
4614:
4611:
4609:
4606:
4604:
4601:
4599:
4596:
4594:
4591:
4589:
4586:
4584:
4581:
4579:
4576:
4574:
4571:
4569:
4566:
4564:
4561:
4559:
4556:
4554:
4551:
4549:
4546:
4545:
4543:
4538:
4535:
4533:
4530:
4528:
4525:
4523:
4520:
4518:
4515:
4513:
4510:
4508:
4505:
4503:
4500:
4499:
4497:
4496:
4494:
4492:
4488:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4453:
4451:
4449:
4445:
4442:
4440:
4436:
4433:
4431:
4426:
4422:
4419:
4415:
4411:
4407:
4400:
4395:
4393:
4388:
4386:
4381:
4380:
4377:
4371:
4368:
4366:
4363:
4362:
4358:
4351:
4347:
4342:
4337:
4333:
4329:
4325:
4320:
4316:
4312:
4307:
4302:
4298:
4294:
4290:
4285:
4281:
4277:
4272:
4267:
4263:
4259:
4255:
4251:
4247:
4241:
4237:
4233:
4228:
4223:
4220:(6): 785–95.
4219:
4215:
4211:
4206:
4202:
4198:
4194:
4190:
4185:
4180:
4176:
4172:
4168:
4164:
4160:
4155:
4151:
4147:
4142:
4137:
4133:
4129:
4125:
4121:
4117:
4112:
4108:
4104:
4099:
4094:
4090:
4086:
4082:
4078:
4074:
4069:
4065:
4061:
4057:
4053:
4049:
4045:
4040:
4036:
4032:
4028:
4024:
4020:
4016:
4012:
4008:
4002:
3998:
3994:
3990:
3986:
3982:
3978:
3973:
3969:
3965:
3961:
3957:
3954:(5): 277–90.
3953:
3949:
3944:
3940:
3936:
3932:
3928:
3924:
3920:
3915:
3914:
3909:
3901:
3897:
3892:
3887:
3883:
3879:
3876:(2): 231–40.
3875:
3871:
3867:
3860:
3857:
3852:
3848:
3843:
3838:
3834:
3830:
3826:
3819:
3816:
3811:
3807:
3802:
3797:
3793:
3789:
3786:(5): 184–90.
3785:
3781:
3777:
3770:
3767:
3762:
3758:
3753:
3748:
3744:
3740:
3736:
3732:
3728:
3721:
3718:
3713:
3709:
3704:
3699:
3695:
3691:
3687:
3683:
3679:
3672:
3669:
3664:
3660:
3655:
3650:
3646:
3642:
3638:
3631:
3628:
3623:
3619:
3614:
3609:
3605:
3601:
3597:
3589:
3586:
3581:
3577:
3573:
3569:
3565:
3561:
3553:
3550:
3545:
3541:
3536:
3531:
3527:
3523:
3520:(5): 428–35.
3519:
3515:
3511:
3504:
3501:
3496:
3492:
3487:
3482:
3478:
3474:
3471:(5): 258–67.
3470:
3466:
3462:
3455:
3452:
3447:
3443:
3439:
3435:
3431:
3427:
3424:(3): 185–92.
3423:
3419:
3412:
3409:
3404:
3400:
3395:
3390:
3386:
3382:
3378:
3371:
3368:
3363:
3359:
3355:
3351:
3347:
3343:
3335:
3332:
3327:
3323:
3318:
3313:
3309:
3305:
3301:
3293:
3290:
3285:
3281:
3277:
3273:
3269:
3265:
3261:
3257:
3250:
3247:
3242:
3238:
3233:
3228:
3224:
3220:
3216:
3209:
3206:
3201:
3197:
3192:
3187:
3184:(4): 400–11.
3183:
3179:
3175:
3168:
3165:
3160:
3156:
3152:
3148:
3143:
3138:
3134:
3130:
3126:
3119:
3116:
3111:
3107:
3102:
3097:
3093:
3089:
3085:
3077:
3074:
3069:
3065:
3061:
3057:
3054:(1): 92–100.
3053:
3049:
3042:
3039:
3034:
3030:
3026:
3022:
3019:(8): 939–44.
3018:
3014:
3006:
3003:
2998:
2994:
2990:
2986:
2981:
2976:
2973:(3): 356–64.
2972:
2968:
2961:
2954:
2951:
2946:
2942:
2937:
2932:
2928:
2924:
2920:
2912:
2909:
2904:
2900:
2895:
2890:
2886:
2882:
2878:
2874:
2870:
2863:
2860:
2855:
2851:
2846:
2841:
2838:(1): 189–94.
2837:
2833:
2829:
2822:
2819:
2814:
2810:
2805:
2800:
2796:
2792:
2788:
2784:
2780:
2772:
2769:
2764:
2760:
2756:
2752:
2749:(4): 258–65.
2748:
2744:
2736:
2733:
2728:
2724:
2719:
2714:
2709:
2704:
2700:
2696:
2692:
2685:
2683:
2679:
2674:
2670:
2665:
2660:
2656:
2652:
2648:
2644:
2640:
2633:
2630:
2625:
2621:
2616:
2611:
2607:
2603:
2599:
2595:
2591:
2584:
2582:
2578:
2573:
2569:
2564:
2559:
2555:
2551:
2547:
2543:
2539:
2532:
2530:
2526:
2521:
2517:
2512:
2507:
2504:(7): 703–11.
2503:
2499:
2495:
2488:
2485:
2480:
2476:
2471:
2466:
2462:
2458:
2454:
2450:
2446:
2439:
2436:
2431:
2427:
2422:
2417:
2413:
2409:
2406:(1): 149–60.
2405:
2401:
2397:
2390:
2387:
2382:
2378:
2373:
2368:
2364:
2360:
2357:(4): 605–13.
2356:
2352:
2348:
2341:
2338:
2333:
2329:
2325:
2321:
2317:
2313:
2310:(7): 542–53.
2309:
2305:
2298:
2295:
2290:
2286:
2281:
2276:
2273:(3): 572–87.
2272:
2268:
2264:
2257:
2254:
2249:
2245:
2240:
2235:
2230:
2225:
2221:
2217:
2213:
2209:
2205:
2198:
2195:
2190:
2186:
2181:
2176:
2172:
2168:
2164:
2157:
2155:
2153:
2151:
2149:
2147:
2145:
2143:
2141:
2137:
2132:
2128:
2124:
2120:
2116:
2112:
2104:
2102:
2098:
2093:
2089:
2084:
2079:
2075:
2071:
2068:(5): 708–16.
2067:
2063:
2059:
2052:
2050:
2046:
2033:
2029:
2025:
2019:
2016:
2003:
1999:
1995:
1989:
1986:
1981:
1975:
1973:
1969:
1964:
1960:
1955:
1950:
1946:
1942:
1938:
1934:
1930:
1923:
1920:
1915:
1911:
1905:
1902:
1897:
1893:
1887:
1884:
1880:
1876:
1871:
1869:
1867:
1863:
1859:
1855:
1850:
1848:
1846:
1842:
1836:
1832:
1829:
1828:
1824:
1819:
1816:
1813:
1810:
1807:
1804:
1801:
1798:
1795:
1792:
1789:
1786:
1783:
1780:
1777:
1776:desmocollin 2
1774:
1771:
1770:desmocollin 1
1768:
1765:
1762:
1759:
1756:
1755:
1754:
1752:
1744:
1742:
1740:
1736:
1732:
1728:
1723:
1721:
1717:
1713:
1709:
1707:
1703:
1699:
1695:
1690:
1688:
1685:
1684:cardiomyocyte
1681:
1677:
1676:extrasystoles
1673:
1669:
1665:
1661:
1657:
1652:
1650:
1646:
1642:
1638:
1635:
1631:
1627:
1623:
1619:
1615:
1611:
1608:Mutations in
1603:
1601:
1599:
1595:
1591:
1587:
1583:
1579:
1575:
1571:
1567:
1563:
1559:
1556:
1552:
1548:
1544:
1539:
1535:
1531:
1527:
1523:
1519:
1515:
1511:
1507:
1503:
1499:
1495:
1492:
1488:
1484:
1480:
1476:
1472:
1471:gap junctions
1468:
1464:
1459:
1457:
1453:
1449:
1443:
1441:
1437:
1433:
1430:
1426:
1422:
1418:
1414:
1413:trabeculation
1410:
1406:
1402:
1398:
1393:
1391:
1387:
1383:
1379:
1375:
1371:
1367:
1364:
1360:
1356:
1352:
1348:
1344:
1341:
1337:
1333:
1329:
1325:
1317:
1315:
1314:head domain.
1313:
1309:
1305:
1300:
1298:
1294:
1290:
1286:
1282:
1278:
1273:
1271:
1267:
1263:
1260:
1256:
1248:
1246:
1244:
1240:
1236:
1232:
1228:
1224:
1220:
1216:
1212:
1209:
1205:
1201:
1200:Plakophilin-2
1189:
1184:
1180:
1176:
1173:
1169:
1162:
1160:
1157:
1153:
1149:
1145:
1142:
1138:
1134:
1127:
1125:
1119:
1115:
1112:
1106:
1104:
1100:
1094:
1090:
1087:
1083:
1076:
1074:
1068:
1064:
1061:
1055:
1053:
1049:
1043:
1039:
1036:
1034:RefSeq (mRNA)
1032:
1025:
1024:
1019:
1015:
1012:
1006:
1005:
1000:
996:
993:
991:
987:
980:
979:
974:
970:
967:
961:
960:
955:
951:
948:
946:
942:
935:
934:
929:
925:
922:
916:
915:
910:
906:
903:
901:
897:
894:
891:
889:
886:
882:
879:
875:
871:
864:
860:
855:
849:
846:
844:
841:
839:
836:
834:
831:
829:
828:cornification
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
798:cell adhesion
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
750:
748:
745:
744:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
712:cell junction
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
674:
672:
669:
668:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
618:
616:
613:
612:
609:
608:Gene ontology
605:
601:
589:
584:
580:
573:
568:
565:
563:
559:
551:
546:
535:
531:
527:
523:
519:
515:
511:
507:
503:
499:
498:
495:
491:
486:
483:
473:
469:
465:
461:
457:
454:right auricle
453:
449:
445:
442:apex of heart
441:
437:
436:
433:
429:
424:
421:
420:
417:
415:
411:
409:
408:
404:
403:
400:
398:
394:
390:
386:
382:
374:
369:
365:
361:
356:
350:16|16 A2
346:
342:
335:
328:
322:
315:
307:
303:
299:
294:
290:
285:
281:
273:
268:
264:
260:
255:
245:
241:
234:
227:
221:
214:
210:
204:
200:
196:
191:
187:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
130:
125:
118:
113:
108:
97:
95:
91:
85:
80:
77:
76:
72:
69:
62:
58:
53:
49:
45:
40:
35:
30:
19:
6701:
6689:
6619:
6464:Dystroglycan
6419:Beta catenin
5651:Microtubules
5519:Beta-keratin
5448:
5397:
5343:
5283:
5205:
5191:
5177:
5114:
4951:
4818:Tropomodulin
4410:cytoskeleton
4331:
4327:
4296:
4292:
4256:(1): 55–65.
4253:
4249:
4217:
4213:
4166:
4162:
4123:
4119:
4080:
4076:
4047:
4043:
4010:
4006:
3980:
3976:
3951:
3947:
3925:(3): 452–4.
3922:
3918:
3873:
3869:
3859:
3832:
3828:
3818:
3783:
3779:
3769:
3734:
3730:
3720:
3685:
3681:
3671:
3647:(3): 225–7.
3644:
3640:
3630:
3606:(6): 861–8.
3603:
3599:
3588:
3563:
3560:Heart Rhythm
3559:
3552:
3517:
3513:
3503:
3468:
3464:
3454:
3421:
3417:
3411:
3384:
3380:
3370:
3345:
3342:Heart Rhythm
3341:
3334:
3307:
3303:
3292:
3262:(7): 450–1.
3259:
3255:
3249:
3222:
3218:
3208:
3181:
3177:
3167:
3132:
3128:
3118:
3091:
3087:
3076:
3051:
3047:
3041:
3016:
3013:Heart Rhythm
3012:
3005:
2970:
2966:
2953:
2926:
2922:
2911:
2876:
2872:
2862:
2835:
2831:
2821:
2786:
2782:
2771:
2746:
2742:
2735:
2698:
2694:
2649:(4): 460–8.
2646:
2642:
2632:
2597:
2593:
2548:(6): 523–6.
2545:
2541:
2501:
2497:
2487:
2452:
2448:
2438:
2403:
2399:
2389:
2354:
2350:
2340:
2307:
2303:
2297:
2270:
2266:
2256:
2211:
2207:
2197:
2170:
2166:
2114:
2111:Heart Rhythm
2110:
2065:
2061:
2036:. Retrieved
2032:the original
2027:
2018:
2006:. Retrieved
2002:the original
1997:
1988:
1936:
1932:
1922:
1913:
1904:
1895:
1886:
1788:desmoglein 2
1782:desmoglein 1
1764:beta catenin
1748:
1745:Interactions
1724:
1711:
1710:
1701:
1691:
1655:
1653:
1644:
1633:
1609:
1607:
1585:
1569:
1547:heterozygous
1542:
1465:, including
1460:
1444:
1432:cytoskeletal
1417:cytoskeletal
1396:
1395:Ablation of
1394:
1321:
1301:
1274:
1258:
1252:
1238:
1223:cytoskeleton
1207:
1199:
1198:
1121:
1099:NP_001005242
1096:
1070:
1052:NM_001005242
1045:
1021:
1002:
976:
957:
931:
912:
892:
887:
412:
405:
132:External IDs
87:
29:
6610:Plakophilin
6561:Desmoplakin
6321:Tau protein
5095:Cytokeratin
4891:Tropomyosin
4439:Myofilament
4293:Circulation
4044:J. Cell Sci
3731:Circulation
3566:(1): 22–9.
3381:Circulation
3304:Circulation
3088:Circulation
2967:Circulation
1933:J Cell Biol
1806:plakoglobin
1800:connexin 43
1794:desmoplakin
1672:ventricular
1660:plakoglobin
1566:arrhythmias
1558:arrhythmias
1555:ventricular
1538:connexin 43
1491:connexin 43
1467:connexin 43
1409:cytoplasmic
1405:desmoplakin
1390:desmoplakin
1378:desmoplakin
1374:plakoglobin
1363:sarcolemmal
1347:desmoplakin
1336:sarcolemmal
1308:desmoplakin
1304:plakoglobin
1270:amino acids
1266:amino acids
707:nucleoplasm
532:Paneth cell
508:gallbladder
371:16,090,576
358:16,031,182
270:32,896,777
257:32,790,755
110:Identifiers
6708:Categories
6690:See also:
6662:Crescentin
6581:Periplakin
6571:Envoplakin
6459:Dystrophin
6076:axonemal:
5570:Internexin
5549:Peripherin
4250:Genome Res
4163:Curr. Biol
4120:Genome Res
1881:, May 2017
1860:, May 2017
1837:References
1706:desmosomal
1698:penetrance
1687:desmosomes
1641:desmosomes
1562:desmosomes
1481:; and the
1421:E-cadherin
1382:desmosomes
1370:N-terminus
1359:C-terminus
1355:sarcolemma
1340:desmosomal
1312:N-terminal
1293:C-terminal
1289:N-terminal
416:(ortholog)
153:HomoloGene
6279:Centrin 3
6274:Centrin 2
6269:Centrin 1
5607:Syncoilin
5512:Not alpha
5078:filaments
5030:Fibrillin
1758:ankyrin G
1530:ankyrin G
1526:ankyrin G
1524:complex,
1479:ankyrin G
1452:cytoplasm
1440:desmosome
1427:early in
1366:cadherins
1328:desmosome
1249:Structure
1231:desmosome
1219:cadherins
1124:NP_080439
1103:NP_004563
1073:NM_026163
1048:NM_004572
878:Orthologs
737:cytoplasm
702:desmosome
161:GeneCards
6645:Nonhuman
6605:Vinculin
6566:Dystonin
6498:Spectrin
6471:Utrophin
6451:Membrane
6406:Catenins
6338:Stathmin
6326:Dynactin
6206:DYNC2LI1
6201:DYNC1LI2
6196:DYNC1LI1
5861:Kinesins
5665:Tubulins
5554:Vimentin
5086:Type 1/2
4988:Profilin
4983:Gelsolin
4845:Troponin
4406:Proteins
4350:17010805
4315:16549640
4280:16344560
4236:15778465
4193:15324660
4150:15231748
4107:12941695
4064:10852826
4035:35411706
4027:10828611
3997:10374265
3968:10374264
3919:Genomics
3900:23929525
3851:20693980
3810:24656989
3761:24352520
3712:25157032
3663:24951656
3622:20400443
3600:Europace
3580:20129281
3544:20031617
3495:18382419
3446:24552922
3438:17413274
3403:17372169
3362:21397041
3326:21606396
3284:20454940
3276:19554004
3241:16893920
3200:22781308
3159:19077857
3151:19533476
3110:16567567
3068:17521752
3033:16876743
2989:16415378
2945:15489853
2903:21301620
2854:22019812
2813:23486541
2763:25765472
2727:23066018
2673:22764151
2624:21617128
2572:19661460
2520:17673670
2479:20554761
2430:15479741
2381:18474624
2332:32003509
2324:15232572
2289:17854763
2248:11416169
2189:11790773
2131:25087486
2092:19674883
1877:–
1856:–
1825:See also
1751:interact
1735:myxomata
1551:Na(V)1.5
1522:Na(V)1.5
1510:Na(V)1.5
1475:Na(V)1.5
1318:Function
1297:isoforms
1172:Wikidata
857:Sources:
249:12p11.21
6632:PLEKHA7
6586:Plectin
6551:Plakins
6476:Ankyrin
6375:Dynamin
6305:Spastin
6300:Katanin
6264:CAMSAP3
6259:CAMSAP2
6254:CAMSAP1
6226:DYNLRB2
6221:DYNLRB1
6191:DYNC1I2
6186:DYNC1I1
6181:DYNC2H1
6176:DYNC1H1
6069:Dyneins
5793:TUBGCP6
5788:TUBGCP5
5783:TUBGCP4
5778:TUBGCP3
5773:TUBGCP2
5602:Synemin
5345:type II
5207:type II
5090:Keratin
5035:Filamin
4976:Destrin
4959:Cofilin
4920:Actinin
4491:Myosins
4408:of the
4271:1356129
4201:2371325
4171:Bibcode
3939:9721216
3891:3797628
3801:4099253
3752:3954430
3703:4465780
3535:2801867
3486:2822988
2894:3018603
2804:3798844
2718:3510824
2664:3422082
2615:3139453
2563:2742576
2470:2921118
2421:2172504
2372:2386101
2216:Bibcode
2083:3091506
2038:11 July
2008:11 July
1963:8922383
1954:2133394
1879:Ensembl
1858:Ensembl
1649:calpain
1494:protein
1450:in the
1368:by its
1357:by its
1353:to the
1343:protein
1281:protein
1257:of the
1204:protein
990:UniProt
945:Ensembl
884:Species
863:QuickGO
722:nucleus
391:pattern
149:1914701
117:Aliases
6533:SPTBN5
6528:SPTBN4
6523:SPTBN2
6518:SPTBN1
6508:SPTAN1
6343:Tektin
6236:DYNLT3
6231:DYNLT1
6216:DYNLL2
6211:DYNLL1
6158:DNALI1
6143:DNAH17
6138:DNAH14
6133:DNAH13
6128:DNAH12
6123:DNAH11
6118:DNAH10
6039:KIF26B
6034:KIF26A
6009:KIF21B
6004:KIF21A
5999:KIF20B
5994:KIF20A
5984:KIF18B
5979:KIF18A
5969:KIF16B
5954:KIF13B
5949:KIF13A
5748:TUBB4Q
5733:TUBB2C
5728:TUBB2B
5723:TUBB2A
5703:TUBA4A
5698:TUBA3E
5693:TUBA3D
5688:TUBA3C
5683:TUBA1C
5678:TUBA1B
5673:TUBA1A
5616:Type 5
5575:Nestin
5563:Type 4
5539:Desmin
5532:Type 3
5285:type I
5116:type I
5062:TRIOBP
4728:MYO18B
4723:MYO18A
4719:XVIII
4713:MYO15A
4448:Actins
4348:
4313:
4278:
4268:
4234:
4199:
4191:
4148:
4141:442148
4138:
4105:
4098:202368
4095:
4077:EMBO J
4062:
4033:
4025:
3995:
3966:
3937:
3898:
3888:
3849:
3808:
3798:
3759:
3749:
3710:
3700:
3661:
3620:
3578:
3542:
3532:
3493:
3483:
3444:
3436:
3401:
3360:
3324:
3282:
3274:
3239:
3198:
3157:
3149:
3108:
3066:
3031:
2997:819048
2995:
2987:
2943:
2901:
2891:
2852:
2811:
2801:
2761:
2725:
2715:
2671:
2661:
2622:
2612:
2570:
2560:
2518:
2477:
2467:
2428:
2418:
2379:
2369:
2330:
2322:
2287:
2246:
2236:
2187:
2129:
2090:
2080:
1961:
1951:
1812:Kir6.2
1753:with:
1668:T-wave
1598:K(ATP)
1594:K(ATP)
1590:K(ATP)
1588:mice,
1578:Kir6.2
1574:K(ATP)
1483:K(ATP)
1456:RPC155
1158:search
1156:PubMed
1023:Q9CQ73
1004:Q99959
900:Entrez
562:BioGPS
528:atrium
470:rectum
141:602861
6593:Talin
6576:MACF1
6544:Other
6503:SPTA1
6368:TEKT5
6363:TEKT4
6358:TEKT3
6353:TEKT2
6348:TEKT1
6331:DCTN1
6314:Other
6168:DNAL4
6163:DNAL1
6153:DNAI2
6148:DNAI1
6113:DNAH9
6108:DNAH8
6103:DNAH7
6098:DNAH6
6093:DNAH5
6088:DNAH3
6083:DNAH2
6078:DNAH1
6059:KIFC3
6054:KIFC2
6049:KIFC1
6044:KIF27
6029:KIF25
6024:KIF24
6019:KIF23
6014:KIF22
5989:KIF19
5974:KIF17
5964:KIF15
5959:KIF14
5944:KIF12
5939:KIF11
5919:KIF5C
5914:KIF5B
5909:KIF5A
5904:KIF4B
5899:KIF4A
5894:KIF3C
5889:KIF3B
5884:KIF2C
5879:KIF2A
5874:KIF1B
5869:KIF1A
5841:MAP1B
5836:MAP1A
5803:TUBE1
5798:TUBD1
5768:TUBG2
5763:TUBG1
5758:TUBB8
5753:TUBB6
5743:TUBB4
5738:TUBB3
5718:TUBB1
5708:TUBA8
5057:Espin
5018:Other
5005:Titin
4811:Other
4800:MYLL1
4795:MYLK2
4785:MYLIP
4770:MYL6B
4703:MYO10
4693:MYO9B
4688:MYO9A
4678:MYO7B
4673:MYO7A
4653:MYO5C
4648:MYO5B
4643:MYO5A
4633:MYO3B
4628:MYO3A
4618:MYH16
4613:MYH15
4608:MYH14
4603:MYH13
4598:MYH11
4593:MYH10
4578:MYH7B
4537:MYO1H
4532:MYO1G
4527:MYO1F
4522:MYO1E
4517:MYO1D
4512:MYO1C
4507:MYO1B
4502:MYO1A
4417:Human
4197:S2CID
4031:S2CID
3442:S2CID
3280:S2CID
3155:S2CID
2993:S2CID
2963:(PDF)
2328:S2CID
2239:35421
1818:SCN5A
1814:, and
1534:siRNA
1487:siRNA
1429:actin
1225:. In
1202:is a
933:67451
893:Mouse
888:Human
859:Amigo
414:Mouse
407:Human
354:Start
289:Mouse
253:Start
186:Human
6677:ParM
6672:MreB
6667:FtsZ
6627:ACF7
6620:PKP2
6615:PKP1
6598:TLN1
6513:SPTB
6491:ANK3
6486:ANK2
6481:ANK1
6390:DNM3
6385:DNM2
6380:DNM1
6284:PCM1
5934:KIF9
5929:KIF7
5924:KIF6
5851:MAP4
5846:MAP2
5813:MAPs
5713:TUBB
5656:MAPs
5654:and
5595:NEFH
5590:NEFM
5585:NEFL
5544:GFAP
5192:none
5050:FLNC
5045:FLNB
5040:FLNA
4790:MYLK
4780:MYL9
4775:MYL7
4765:MYL6
4760:MYL5
4755:MYL4
4750:MYL3
4745:MYL2
4740:MYL1
4669:VII
4663:MYO6
4624:III
4588:MYH9
4583:MYH8
4573:MYH7
4568:MYH6
4563:MYH4
4558:MYH3
4553:MYH2
4548:MYH1
4430:ABPs
4428:and
4346:PMID
4311:PMID
4276:PMID
4232:PMID
4189:PMID
4146:PMID
4103:PMID
4060:PMID
4023:PMID
3993:PMID
3964:PMID
3935:PMID
3896:PMID
3847:PMID
3806:PMID
3757:PMID
3708:PMID
3659:PMID
3618:PMID
3576:PMID
3540:PMID
3491:PMID
3434:PMID
3399:PMID
3358:PMID
3322:PMID
3272:PMID
3237:PMID
3196:PMID
3147:PMID
3106:PMID
3064:PMID
3029:PMID
2985:PMID
2941:PMID
2899:PMID
2850:PMID
2809:PMID
2759:PMID
2723:PMID
2669:PMID
2620:PMID
2568:PMID
2516:PMID
2475:PMID
2426:PMID
2377:PMID
2320:PMID
2285:PMID
2271:1778
2244:PMID
2185:PMID
2127:PMID
2088:PMID
2040:2015
2010:2015
1959:PMID
1712:PKP2
1702:PKP2
1658:and
1656:PKP2
1645:PKP2
1637:gene
1634:PKP2
1624:and
1610:PKP2
1586:PKP2
1570:PKP2
1543:PKP2
1532:via
1502:GJA1
1425:RhoA
1397:PKP2
1291:and
1262:gene
1259:PKP2
1253:Two
1239:PKP2
1211:gene
1208:PKP2
914:5318
397:Bgee
345:Band
306:Chr.
244:Band
203:Chr.
165:PKP2
157:3364
137:OMIM
124:PKP2
94:3TT9
92:,%%s
90:3TT9
71:RCSB
68:PDBe
42:PKP2
18:PKP2
6441:GAN
6424:APC
5831:EB3
5826:EB2
5821:EB1
5627:A/C
5310:33B
5305:33A
4709:XV
4684:IX
4659:VI
4544:II
4336:doi
4301:doi
4297:113
4266:PMC
4258:doi
4222:doi
4179:doi
4136:PMC
4128:doi
4093:PMC
4085:doi
4052:doi
4048:113
4015:doi
3985:doi
3956:doi
3927:doi
3886:PMC
3878:doi
3874:100
3837:doi
3796:PMC
3788:doi
3747:PMC
3739:doi
3735:129
3698:PMC
3690:doi
3649:doi
3608:doi
3568:doi
3530:PMC
3522:doi
3481:PMC
3473:doi
3426:doi
3389:doi
3385:115
3350:doi
3312:doi
3308:123
3264:doi
3227:doi
3186:doi
3137:doi
3096:doi
3092:113
3056:doi
3052:126
3021:doi
2975:doi
2971:113
2931:doi
2889:PMC
2881:doi
2840:doi
2799:PMC
2791:doi
2751:doi
2713:PMC
2703:doi
2699:287
2659:PMC
2651:doi
2610:PMC
2602:doi
2598:109
2558:PMC
2550:doi
2546:105
2506:doi
2502:101
2465:PMC
2457:doi
2416:PMC
2408:doi
2404:167
2367:PMC
2359:doi
2355:181
2312:doi
2275:doi
2234:PMC
2224:doi
2175:doi
2171:277
2119:doi
2078:PMC
2070:doi
1949:PMC
1941:doi
1937:135
1729:of
1388:to
1380:to
367:End
266:End
169:OMA
145:MGI
61:PDB
6710::
5637:B2
5632:B1
5625::
5501:80
5496:79
5491:78
5486:77
5481:76
5476:75
5471:74
5466:73
5461:72
5456:71
5440:40
5435:39
5430:28
5425:27
5420:26
5415:25
5410:24
5405:23
5380:86
5375:85
5370:84
5365:83
5360:82
5355:81
5335:38
5330:37
5325:36
5320:35
5315:34
5300:32
5295:31
5252:6C
5247:6B
5242:6A
5222:2A
5197:21
5185:18
5171:20
5166:19
5161:17
5156:16
5151:15
5146:14
5141:13
5136:12
5131:10
4735:LC
4699:X
4639:V
4498:I
4481:G2
4476:G1
4471:C1
4461:A2
4456:A1
4344:.
4332:48
4330:.
4326:.
4309:.
4295:.
4291:.
4274:.
4264:.
4254:16
4252:.
4248:.
4230:.
4216:.
4212:.
4195:.
4187:.
4177:.
4167:14
4165:.
4161:.
4144:.
4134:.
4124:14
4122:.
4118:.
4101:.
4091:.
4081:22
4079:.
4075:.
4058:.
4046:.
4029:.
4021:.
4011:88
4009:.
3991:.
3981:64
3979:.
3962:.
3952:64
3950:.
3933:.
3923:51
3921:.
3894:.
3884:.
3872:.
3868:.
3845:.
3833:23
3831:.
3827:.
3804:.
3794:.
3784:24
3782:.
3778:.
3755:.
3745:.
3733:.
3729:.
3706:.
3696:.
3686:51
3684:.
3680:.
3657:.
3643:.
3639:.
3616:.
3604:12
3602:.
3598:.
3574:.
3562:.
3538:.
3528:.
3516:.
3512:.
3489:.
3479:.
3467:.
3463:.
3440:.
3432:.
3422:22
3420:.
3397:.
3383:.
3379:.
3356:.
3344:.
3320:.
3306:.
3302:.
3278:.
3270:.
3258:.
3235:.
3223:27
3221:.
3217:.
3194:.
3180:.
3176:.
3153:.
3145:.
3133:16
3131:.
3127:.
3104:.
3090:.
3086:.
3062:.
3050:.
3027:.
3015:.
2991:.
2983:.
2969:.
2965:.
2939:.
2927:36
2925:.
2921:.
2897:.
2887:.
2877:18
2875:.
2871:.
2848:.
2836:76
2834:.
2830:.
2807:.
2797:.
2787:21
2785:.
2781:.
2757:.
2747:58
2745:.
2721:.
2711:.
2697:.
2693:.
2681:^
2667:.
2657:.
2647:95
2645:.
2641:.
2618:.
2608:.
2596:.
2592:.
2580:^
2566:.
2556:.
2544:.
2540:.
2528:^
2514:.
2500:.
2496:.
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