314:
291:
188:
213:
565:
320:
219:
33:
3483:
1178:
C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.
1177:
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes,
1777:
Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line".
59:
1938:"Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase"
1531:"Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase"
1493:
Boudot C, Kadri Z, Petitfrère E, Lambert E, Chrétien S, Mayeux P, Haye B, Billat C (October 2002). "Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells".
1578:
Perskvist N, Zheng L, Stendahl O (January 2000). "Activation of human neutrophils by
Mycobacterium tuberculosis H37Ra involves phospholipase C gamma 2, Shc adapter protein, and p38 mitogen-activated protein kinase".
2304:
Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat".
2195:
Tomassetti A, Bottero F, Mazzi M, Miotti S, Colnaghi MI, Canevari S (1999). "Molecular requirements for attachment of the glycosylphosphatidylinositol anchor to the human alpha folate receptor".
1748:
Yan W, Ratnam M (1995). "Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal".
2271:"Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets"
2154:"Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity"
2115:
Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease".
1317:
Hernandez D, Egan SE, Yulug IG, Fisher EM (February 1995). "Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse".
327:
226:
2086:
Cunningham SA, Arrate MP, Brock TA, Waxham MN (1997). "Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites".
2014:
Kang JS, Kohlhuber F, Hug H, Marmé D, Eick D, Ueffing M (1996). "Cloning and functional analysis of the hematopoietic cell-specific phospholipase C(gamma)2 promoter".
2232:
Shen Z, Batzer A, Koehler JA, Polakis P, Schlessinger J, Lydon NB, Moran MF (1999). "Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src".
1664:"Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway"
888:
149:
869:
2557:
2804:
1299:
3503:
1281:
2718:
1860:"Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization"
2819:
2813:
2614:
2364:
2208:
313:
2662:
1095:
1088:
3202:
2773:
2562:
290:
2053:"The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases"
1352:
1903:"Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex"
2880:
2768:
1268:
1247:
2689:
2599:
2552:
212:
187:
3358:
1264:
56:
3111:
3052:
3473:
1243:
3156:
2723:
2713:
129:
3116:
3008:
2633:
1188:
1981:"Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling"
1195:
326:
225:
2702:
2698:
2694:
2610:
2443:
3343:
319:
218:
3459:
3446:
3433:
3420:
3407:
3394:
3381:
2964:
2910:
2870:
2829:
2733:
2572:
2540:
2426:
2390:
3353:
3307:
3250:
2618:
2467:
2381:
933:
137:
3255:
2487:
2357:
914:
1817:"In vitro tyrosine phosphorylation of PLC-gamma 1 & PLC-gamma 2 by src-family protein tyrosine kinases"
1529:
Pleiman CM, Clark MR, Gauen LK, Winitz S, Coggeshall KM, Johnson GL, Shaw AS, Cambier JC (September 1993).
3043:
2682:
3276:
3195:
2978:
2875:
2667:
2628:
2492:
2414:
1400:"Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex"
201:
3348:
3161:
2996:
2991:
2924:
2584:
2409:
116:
3312:
3016:
2986:
2790:
2785:
2709:
2645:
2431:
3245:
3149:
3001:
2482:
2472:
2350:
2330:
2257:
2220:
2140:
2039:
1936:
Pleiman CM, Clark MR, Gauen LK, Winitz S, Coggeshall KM, Johnson GL, Shaw AS, Cambier JC (1993).
1803:
1736:
1604:
161:
1071:
1050:
1024:
1003:
3508:
2950:
2895:
2863:
2738:
2457:
2322:
2292:
2249:
2212:
2183:
2132:
2103:
2074:
2031:
2002:
1967:
1924:
1889:
1846:
1795:
1765:
1728:
1693:
1650:
1596:
1560:
1511:
1470:
1421:
1334:
109:
49:
1439:
Yasuda T, Tezuka T, Maeda A, Inazu T, Yamanashi Y, Gu H, Kurosaki T, Yamamoto T (July 2002).
3291:
3286:
3260:
3188:
3026:
2606:
2511:
2506:
2462:
2314:
2282:
2241:
2204:
2173:
2165:
2124:
2095:
2064:
2023:
1992:
1957:
1949:
1914:
1879:
1871:
1836:
1828:
1787:
1757:
1718:
1683:
1675:
1640:
1588:
1550:
1542:
1503:
1460:
1452:
1411:
1326:
406:
337:
281:
236:
564:
157:
3338:
3322:
3235:
3128:
2942:
2858:
2853:
2848:
2761:
2756:
2516:
2394:
381:
1441:"Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells"
3487:
3376:
3317:
3101:
3096:
3091:
2477:
2452:
2448:
2421:
2404:
2318:
1884:
1859:
1465:
1440:
32:
2178:
2153:
2027:
1997:
1980:
1962:
1937:
1919:
1902:
1841:
1816:
1707:"Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes"
1688:
1663:
1645:
1628:
1555:
1530:
1507:
1416:
1399:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
662:
657:
652:
636:
631:
626:
621:
616:
611:
3497:
3281:
3240:
2842:
2751:
2501:
2287:
2270:
1723:
1706:
593:
2334:
2261:
2224:
2144:
2043:
1979:
Sidorenko SP, Law CL, Klaus SJ, Chandran KA, Takata M, Kurosaki T, Clark EA (1996).
1807:
1740:
1608:
3230:
2969:
2900:
2623:
2544:
399:
178:
141:
1901:
Obermeier A, Lammers R, WiesmĂĽller KH, Jung G, Schlessinger J, Ullrich A (1993).
165:
3454:
3389:
3225:
3144:
2915:
2809:
2672:
2638:
2576:
2342:
1304:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1286:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3482:
1592:
482:
3121:
298:
195:
145:
2069:
2052:
1353:"Entrez Gene: PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)"
3428:
3402:
3034:
2833:
2746:
2373:
833:
606:
542:
420:
365:
352:
264:
251:
153:
2326:
2296:
2253:
2245:
2216:
2209:
10.1002/(SICI)1097-4644(19990101)72:1<111::AID-JCB12>3.0.CO;2-1
2169:
2099:
1832:
1791:
1654:
1600:
1515:
1474:
1425:
1330:
2187:
2136:
2107:
2078:
2035:
2006:
1971:
1953:
1928:
1893:
1850:
1799:
1769:
1732:
1697:
1564:
1546:
1338:
1135:
1130:
3079:
3074:
3069:
2890:
2525:
2377:
1456:
1119:
978:
959:
1761:
3086:
3064:
3059:
2677:
945:
900:
2128:
1875:
1679:
1662:
Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1990).
86:
82:
78:
3441:
3211:
3106:
3039:
2932:
2530:
2438:
1398:
Guo B, Kato RM, Garcia-Lloret M, Wahl MI, Rawlings DJ (August 2000).
1213:
1151:
1103:
855:
1367:
3415:
3048:
2799:
2795:
1148:
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
818:
814:
2780:
2657:
2650:
2594:
2589:
1372:
1219:
1201:
1170:
1158:
133:
3184:
2346:
573:
1207:
120:, APLAID, FCAS3, PLC-IV, PLC-gamma-2, phospholipase C gamma 2
699:
Fc-gamma receptor signaling pathway involved in phagocytosis
3180:
2152:
Bai RY, Dieter P, Peschel C, Morris SW, Duyster J (1998).
389:
1629:"Xid-like phenotypes: a B cell signalosome takes shape"
3471:
784:
activation of store-operated calcium channel activity
554:
714:
stimulatory C-type lectin receptor signaling pathway
3367:
3331:
3300:
3269:
3218:
3137:
3025:
2977:
2963:
2941:
2923:
2909:
2889:
2828:
2732:
2571:
2539:
2389:
1064:
1043:
1017:
996:
789:
positive regulation of type I interferon production
1260:
1258:
1256:
1239:
1237:
1235:
2668:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
336:
235:
1488:
1486:
1484:
704:positive regulation of receptor internalization
684:release of sequestered calcium ion into cytosol
18:Protein-coding gene in the species Homo sapiens
1627:Fruman DA, Satterthwaite AB, Witte ON (2000).
1393:
1391:
1265:GRCm38: Ensembl release 89: ENSMUSG00000034330
3196:
2358:
1705:Ohta S, Matsui A, Nazawa Y, Kagawa Y (1988).
632:phosphatidylinositol phospholipase C activity
8:
769:negative regulation of programmed cell death
1858:Daniel JL, Dangelmaier C, Smith JB (1994).
1244:GRCh38: Ensembl release 89: ENSG00000197943
694:inositol trisphosphate biosynthetic process
3203:
3189:
3181:
2974:
2920:
2906:
2365:
2351:
2343:
829:
589:
377:
276:
173:
67:
2286:
2177:
2068:
2051:Chen P, Mayne M, Power C, Nath A (1997).
1996:
1961:
1918:
1883:
1840:
1722:
1687:
1644:
1554:
1464:
1415:
1368:"600220: PHOSPHOLIPASE C, GAMMA-2; PLCG2"
764:phosphatidylinositol biosynthetic process
2269:Gross BS, Melford SK, Watson SP (1999).
3478:
2558:Ubiquitin carboxy-terminal hydrolase L1
1231:
804:phosphatidylinositol-mediated signaling
22:
3138:either deoxy- or ribo-
734:Fc-epsilon receptor signaling pathway
617:phosphoric diester hydrolase activity
341:
302:
297:
240:
199:
194:
7:
2719:Protein serine/threonine phosphatase
719:inositol phosphate metabolic process
2820:Cyclic nucleotide phosphodiesterase
2814:Clostridium perfringens alpha toxin
2615:Tartrate-resistant acid phosphatase
2663:Pyruvate dehydrogenase phosphatase
2319:10.1046/j.1471-4159.1999.0731363.x
1061:
1040:
1014:
993:
969:
950:
924:
905:
879:
860:
559:
477:
415:
394:
14:
2563:4-hydroxybenzoyl-CoA thioesterase
1815:Liao F, Shin HS, Rhee SG (1993).
1154:that in humans is encoded by the
779:T cell receptor signaling pathway
744:follicular B cell differentiation
689:intracellular signal transduction
679:B cell receptor signaling pathway
3481:
2288:10.1046/j.1432-1327.1999.00560.x
563:
325:
318:
312:
289:
224:
217:
211:
186:
31:
2881:N-acetylglucosamine-6-sulfatase
2769:Sphingomyelin phosphodiesterase
637:phosphotyrosine residue binding
2690:Inositol-phosphate phosphatase
2553:Palmitoyl protein thioesterase
1366:Bocchini CA (March 24, 2020).
754:phospholipid catabolic process
749:response to lipopolysaccharide
574:More reference expression data
543:More reference expression data
493:basilar part of occipital bone
1:
3053:RNA-induced silencing complex
2088:Biochem. Biophys. Res. Commun
2028:10.1016/S0014-5793(96)01276-8
1998:10.1016/S1074-7613(00)80261-7
1920:10.1016/S0021-9258(19)49410-6
1821:Biochem. Biophys. Res. Commun
1646:10.1016/S1074-7613(00)00002-9
1508:10.1016/s0898-6568(02)00036-0
1417:10.1016/s1074-7613(00)00024-8
759:regulation of gene expression
310:
209:
3504:Genes on human chromosome 16
3157:Serratia marcescens nuclease
2724:Dual-specificity phosphatase
2714:Protein tyrosine phosphatase
1724:10.1016/0014-5793(88)80979-7
2634:Fructose 1,6-bisphosphatase
3525:
1593:10.4049/jimmunol.164.2.959
1376:. Johns Hopkins University
794:calcium-mediated signaling
607:signal transducer activity
3359:Michaelis–Menten kinetics
2871:Galactosamine-6 sulfatase
2427:6-phosphogluconolactonase
1300:"Mouse PubMed Reference:"
1282:"Human PubMed Reference:"
1134:
1129:
1125:
1118:
1102:
1096:Chr 8: 118.23 – 118.36 Mb
1083:
1068:
1047:
1036:
1021:
1000:
989:
976:
972:
957:
953:
944:
931:
927:
912:
908:
899:
886:
882:
867:
863:
854:
839:
832:
828:
812:
592:
588:
571:
562:
553:
540:
489:
480:
447:epithelium of nasopharynx
427:
418:
388:
380:
376:
359:
346:
309:
288:
279:
275:
258:
245:
208:
185:
176:
172:
127:
124:
114:
107:
102:
75:
70:
53:
48:
43:
39:
30:
25:
3251:Diffusion-limited enzyme
2619:Purple acid phosphatases
2070:10.1074/jbc.272.36.22385
1196:Bruton's tyrosine kinase
1187:PLCG2 has been shown to
1089:Chr 16: 81.74 – 81.96 Mb
622:phospholipase C activity
739:lipid catabolic process
529:internal carotid artery
525:external carotid artery
3044:Microprocessor complex
2683:Beta-propeller phytase
2246:10.1038/sj.onc.1203079
2170:10.1128/mcb.18.12.6951
2100:10.1006/bbrc.1997.7719
1833:10.1006/bbrc.1993.1320
1792:10.1002/eji.1830250944
1331:10.1006/geno.1994.1533
1180:
1173:as of March 24, 2020:
774:B cell differentiation
505:mesenteric lymph nodes
443:metanephric glomerulus
3344:Eadie–Hofstee diagram
3277:Allosteric regulation
2979:Endodeoxyribonuclease
2876:Iduronate-2-sulfatase
2629:Glucose 6-phosphatase
2415:Butyrylcholinesterase
2117:Neuroimmunomodulation
1954:10.1128/MCB.13.9.5877
1547:10.1128/MCB.13.9.5877
1175:
724:Wnt signaling pathway
663:extracellular exosome
202:Chromosome 16 (human)
3354:Lineweaver–Burk plot
3162:Micrococcal nuclease
2997:Deoxyribonuclease IV
2992:Deoxyribonuclease II
2925:Exodeoxyribonuclease
2585:Alkaline phosphatase
2410:Acetylcholinesterase
1457:10.1084/jem.20020068
343:8 E1|8 64.26 cM
304:Chromosome 8 (mouse)
71:List of PDB id codes
44:Available structures
3017:UvrABC endonuclease
2987:Deoxyribonuclease I
2710:Protein phosphatase
2646:Protein phosphatase
2444:Bile salt-dependent
2432:PAF acetylhydrolase
1762:10.1021/bi00044a039
799:signal transduction
729:platelet activation
3313:Enzyme superfamily
3246:Enzyme promiscuity
3150:Mung bean nuclease
3009:Restriction enzyme
3002:Restriction enzyme
934:ENSMUSG00000034330
672:Biological process
646:Cellular component
627:hydrolase activity
600:Molecular function
501:tibiofemoral joint
3469:
3468:
3178:
3177:
3174:
3173:
3170:
3169:
2959:
2958:
2951:Oligonucleotidase
2896:deoxyribonuclease
2864:Steroid sulfatase
2739:Phosphodiesterase
2468:Hormone-sensitive
2129:10.1159/000026336
1876:10.1042/bj3020617
1756:(44): 14594–600.
1680:10.1172/JCI114950
1145:
1144:
1141:
1140:
1114:
1113:
1079:
1078:
1058:
1057:
1032:
1031:
1011:
1010:
985:
984:
966:
965:
940:
939:
921:
920:
895:
894:
876:
875:
824:
823:
584:
583:
580:
579:
549:
548:
536:
535:
474:
473:
435:bone marrow cells
372:
371:
271:
270:
166:PLCG2 - orthologs
98:
97:
94:
93:
54:Ortholog search:
3516:
3486:
3485:
3477:
3349:Hanes–Woolf plot
3292:Enzyme activator
3287:Enzyme inhibitor
3261:Enzyme catalysis
3205:
3198:
3191:
3182:
3027:Endoribonuclease
3013:
3007:
2975:
2921:
2907:
2607:Acid phosphatase
2488:Monoacylglycerol
2398:ester hydrolases
2367:
2360:
2353:
2344:
2338:
2300:
2290:
2265:
2228:
2197:J. Cell. Biochem
2191:
2181:
2148:
2111:
2082:
2072:
2047:
2010:
2000:
1975:
1965:
1932:
1922:
1897:
1887:
1854:
1844:
1827:(3): 1028–1033.
1811:
1773:
1744:
1726:
1701:
1691:
1658:
1648:
1613:
1612:
1575:
1569:
1568:
1558:
1526:
1520:
1519:
1490:
1479:
1478:
1468:
1436:
1430:
1429:
1419:
1395:
1386:
1385:
1383:
1381:
1363:
1357:
1356:
1349:
1343:
1342:
1314:
1308:
1307:
1296:
1290:
1289:
1278:
1272:
1262:
1251:
1241:
1127:
1126:
1098:
1091:
1074:
1062:
1053:
1041:
1037:RefSeq (protein)
1027:
1015:
1006:
994:
970:
951:
925:
906:
880:
861:
830:
709:lipid metabolism
590:
576:
567:
560:
545:
485:
483:Top expressed in
478:
459:endothelial cell
423:
421:Top expressed in
416:
395:
378:
368:
355:
344:
329:
322:
316:
305:
293:
277:
267:
254:
243:
228:
221:
215:
204:
190:
174:
168:
119:
112:
89:
68:
62:
41:
40:
35:
23:
3524:
3523:
3519:
3518:
3517:
3515:
3514:
3513:
3494:
3493:
3492:
3480:
3472:
3470:
3465:
3377:Oxidoreductases
3363:
3339:Enzyme kinetics
3327:
3323:List of enzymes
3296:
3265:
3236:Catalytic triad
3214:
3209:
3179:
3166:
3133:
3021:
3011:
3005:
2968:
2955:
2943:Exoribonuclease
2937:
2914:
2898:
2894:
2885:
2859:Arylsulfatase L
2854:Arylsulfatase B
2849:Arylsulfatase A
2824:
2737:
2728:
2567:
2535:
2397:
2385:
2371:
2341:
2303:
2275:Eur. J. Biochem
2268:
2240:(33): 4647–53.
2231:
2194:
2164:(12): 6951–61.
2158:Mol. Cell. Biol
2151:
2123:(3–4): 184–92.
2114:
2085:
2063:(36): 22385–8.
2050:
2013:
1978:
1942:Mol. Cell. Biol
1935:
1913:(31): 22963–6.
1900:
1857:
1814:
1786:(9): 2695–700.
1780:Eur. J. Immunol
1776:
1747:
1704:
1668:J. Clin. Invest
1661:
1626:
1622:
1620:Further reading
1617:
1616:
1577:
1576:
1572:
1535:Mol. Cell. Biol
1528:
1527:
1523:
1492:
1491:
1482:
1438:
1437:
1433:
1397:
1396:
1389:
1379:
1377:
1365:
1364:
1360:
1351:
1350:
1346:
1316:
1315:
1311:
1298:
1297:
1293:
1280:
1279:
1275:
1263:
1254:
1242:
1233:
1228:
1185:
1167:
1136:View/Edit Mouse
1131:View/Edit Human
1094:
1087:
1084:Location (UCSC)
1070:
1049:
1023:
1002:
915:ENSG00000197943
808:
667:
658:plasma membrane
641:
612:protein binding
572:
541:
532:
527:
523:
519:
515:
511:
507:
503:
499:
495:
481:
470:
465:
461:
457:
453:
449:
445:
441:
437:
433:
419:
363:
350:
342:
332:
331:
330:
323:
303:
280:Gene location (
262:
249:
241:
231:
230:
229:
222:
200:
177:Gene location (
128:
115:
108:
77:
55:
19:
12:
11:
5:
3522:
3520:
3512:
3511:
3506:
3496:
3495:
3491:
3490:
3467:
3466:
3464:
3463:
3450:
3437:
3424:
3411:
3398:
3385:
3371:
3369:
3365:
3364:
3362:
3361:
3356:
3351:
3346:
3341:
3335:
3333:
3329:
3328:
3326:
3325:
3320:
3315:
3310:
3304:
3302:
3301:Classification
3298:
3297:
3295:
3294:
3289:
3284:
3279:
3273:
3271:
3267:
3266:
3264:
3263:
3258:
3253:
3248:
3243:
3238:
3233:
3228:
3222:
3220:
3216:
3215:
3210:
3208:
3207:
3200:
3193:
3185:
3176:
3175:
3172:
3171:
3168:
3167:
3165:
3164:
3159:
3154:
3153:
3152:
3141:
3139:
3135:
3134:
3132:
3131:
3126:
3125:
3124:
3119:
3114:
3109:
3099:
3094:
3089:
3084:
3083:
3082:
3077:
3072:
3067:
3057:
3056:
3055:
3046:
3031:
3029:
3023:
3022:
3020:
3019:
3014:
2999:
2994:
2989:
2983:
2981:
2972:
2961:
2960:
2957:
2956:
2954:
2953:
2947:
2945:
2939:
2938:
2936:
2935:
2929:
2927:
2918:
2904:
2887:
2886:
2884:
2883:
2878:
2873:
2868:
2867:
2866:
2861:
2856:
2851:
2838:
2836:
2826:
2825:
2823:
2822:
2817:
2807:
2802:
2793:
2788:
2783:
2778:
2777:
2776:
2766:
2765:
2764:
2759:
2749:
2743:
2741:
2730:
2729:
2727:
2726:
2721:
2716:
2707:
2706:
2705:
2687:
2686:
2685:
2675:
2670:
2665:
2660:
2655:
2654:
2653:
2643:
2642:
2641:
2631:
2626:
2621:
2604:
2603:
2602:
2597:
2592:
2581:
2579:
2569:
2568:
2566:
2565:
2560:
2555:
2549:
2547:
2537:
2536:
2534:
2533:
2528:
2522:
2521:
2520:
2519:
2514:
2509:
2498:
2497:
2496:
2495:
2493:Diacylglycerol
2490:
2485:
2480:
2475:
2470:
2465:
2460:
2455:
2446:
2435:
2434:
2429:
2424:
2422:Pectinesterase
2419:
2418:
2417:
2412:
2405:Cholinesterase
2401:
2399:
2387:
2386:
2372:
2370:
2369:
2362:
2355:
2347:
2340:
2339:
2313:(4): 1363–74.
2301:
2266:
2229:
2192:
2149:
2112:
2083:
2048:
2022:(1–2): 14–20.
2011:
1976:
1948:(9): 5877–87.
1933:
1898:
1855:
1812:
1774:
1745:
1702:
1674:(6): 2117–24.
1659:
1623:
1621:
1618:
1615:
1614:
1570:
1541:(9): 5877–87.
1521:
1502:(10): 869–78.
1480:
1431:
1387:
1358:
1344:
1309:
1291:
1273:
1252:
1230:
1229:
1227:
1224:
1223:
1222:
1217:
1211:
1205:
1199:
1184:
1181:
1166:
1163:
1143:
1142:
1139:
1138:
1133:
1123:
1122:
1116:
1115:
1112:
1111:
1109:
1107:
1100:
1099:
1092:
1085:
1081:
1080:
1077:
1076:
1066:
1065:
1059:
1056:
1055:
1045:
1044:
1038:
1034:
1033:
1030:
1029:
1019:
1018:
1012:
1009:
1008:
998:
997:
991:
987:
986:
983:
982:
974:
973:
967:
964:
963:
955:
954:
948:
942:
941:
938:
937:
929:
928:
922:
919:
918:
910:
909:
903:
897:
896:
893:
892:
884:
883:
877:
874:
873:
865:
864:
858:
852:
851:
846:
841:
837:
836:
826:
825:
822:
821:
810:
809:
807:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
675:
673:
669:
668:
666:
665:
660:
655:
649:
647:
643:
642:
640:
639:
634:
629:
624:
619:
614:
609:
603:
601:
597:
596:
586:
585:
582:
581:
578:
577:
569:
568:
557:
551:
550:
547:
546:
538:
537:
534:
533:
531:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
487:
486:
475:
472:
471:
469:
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
425:
424:
412:
411:
403:
392:
386:
385:
382:RNA expression
374:
373:
370:
369:
361:
357:
356:
348:
345:
340:
334:
333:
324:
317:
311:
307:
306:
301:
295:
294:
286:
285:
273:
272:
269:
268:
260:
256:
255:
247:
244:
239:
233:
232:
223:
216:
210:
206:
205:
198:
192:
191:
183:
182:
170:
169:
126:
122:
121:
113:
105:
104:
100:
99:
96:
95:
92:
91:
73:
72:
64:
63:
52:
46:
45:
37:
36:
28:
27:
17:
13:
10:
9:
6:
4:
3:
2:
3521:
3510:
3507:
3505:
3502:
3501:
3499:
3489:
3484:
3479:
3475:
3461:
3457:
3456:
3451:
3448:
3444:
3443:
3438:
3435:
3431:
3430:
3425:
3422:
3418:
3417:
3412:
3409:
3405:
3404:
3399:
3396:
3392:
3391:
3386:
3383:
3379:
3378:
3373:
3372:
3370:
3366:
3360:
3357:
3355:
3352:
3350:
3347:
3345:
3342:
3340:
3337:
3336:
3334:
3330:
3324:
3321:
3319:
3318:Enzyme family
3316:
3314:
3311:
3309:
3306:
3305:
3303:
3299:
3293:
3290:
3288:
3285:
3283:
3282:Cooperativity
3280:
3278:
3275:
3274:
3272:
3268:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3241:Oxyanion hole
3239:
3237:
3234:
3232:
3229:
3227:
3224:
3223:
3221:
3217:
3213:
3206:
3201:
3199:
3194:
3192:
3187:
3186:
3183:
3163:
3160:
3158:
3155:
3151:
3148:
3147:
3146:
3143:
3142:
3140:
3136:
3130:
3127:
3123:
3120:
3118:
3115:
3113:
3110:
3108:
3105:
3104:
3103:
3100:
3098:
3095:
3093:
3090:
3088:
3085:
3081:
3078:
3076:
3073:
3071:
3068:
3066:
3063:
3062:
3061:
3058:
3054:
3050:
3047:
3045:
3041:
3038:
3037:
3036:
3033:
3032:
3030:
3028:
3024:
3018:
3015:
3010:
3003:
3000:
2998:
2995:
2993:
2990:
2988:
2985:
2984:
2982:
2980:
2976:
2973:
2971:
2966:
2962:
2952:
2949:
2948:
2946:
2944:
2940:
2934:
2931:
2930:
2928:
2926:
2922:
2919:
2917:
2912:
2908:
2905:
2902:
2897:
2892:
2888:
2882:
2879:
2877:
2874:
2872:
2869:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2846:
2845:
2844:
2843:arylsulfatase
2840:
2839:
2837:
2835:
2831:
2827:
2821:
2818:
2815:
2811:
2808:
2806:
2803:
2801:
2797:
2794:
2792:
2789:
2787:
2784:
2782:
2779:
2775:
2772:
2771:
2770:
2767:
2763:
2760:
2758:
2755:
2754:
2753:
2752:Phospholipase
2750:
2748:
2745:
2744:
2742:
2740:
2735:
2731:
2725:
2722:
2720:
2717:
2715:
2711:
2708:
2704:
2700:
2696:
2693:
2692:
2691:
2688:
2684:
2681:
2680:
2679:
2676:
2674:
2671:
2669:
2666:
2664:
2661:
2659:
2656:
2652:
2649:
2648:
2647:
2644:
2640:
2637:
2636:
2635:
2632:
2630:
2627:
2625:
2622:
2620:
2616:
2612:
2608:
2605:
2601:
2598:
2596:
2593:
2591:
2588:
2587:
2586:
2583:
2582:
2580:
2578:
2574:
2570:
2564:
2561:
2559:
2556:
2554:
2551:
2550:
2548:
2546:
2542:
2538:
2532:
2529:
2527:
2524:
2523:
2518:
2515:
2513:
2510:
2508:
2505:
2504:
2503:
2502:Phospholipase
2500:
2499:
2494:
2491:
2489:
2486:
2484:
2481:
2479:
2476:
2474:
2471:
2469:
2466:
2464:
2461:
2459:
2456:
2454:
2450:
2447:
2445:
2442:
2441:
2440:
2437:
2436:
2433:
2430:
2428:
2425:
2423:
2420:
2416:
2413:
2411:
2408:
2407:
2406:
2403:
2402:
2400:
2396:
2392:
2388:
2383:
2379:
2375:
2368:
2363:
2361:
2356:
2354:
2349:
2348:
2345:
2336:
2332:
2328:
2324:
2320:
2316:
2312:
2308:
2302:
2298:
2294:
2289:
2284:
2281:(3): 612–23.
2280:
2276:
2272:
2267:
2263:
2259:
2255:
2251:
2247:
2243:
2239:
2235:
2230:
2226:
2222:
2218:
2214:
2210:
2206:
2202:
2198:
2193:
2189:
2185:
2180:
2175:
2171:
2167:
2163:
2159:
2155:
2150:
2146:
2142:
2138:
2134:
2130:
2126:
2122:
2118:
2113:
2109:
2105:
2101:
2097:
2093:
2089:
2084:
2080:
2076:
2071:
2066:
2062:
2058:
2057:J. Biol. Chem
2054:
2049:
2045:
2041:
2037:
2033:
2029:
2025:
2021:
2017:
2012:
2008:
2004:
1999:
1994:
1991:(4): 353–63.
1990:
1986:
1982:
1977:
1973:
1969:
1964:
1959:
1955:
1951:
1947:
1943:
1939:
1934:
1930:
1926:
1921:
1916:
1912:
1908:
1907:J. Biol. Chem
1904:
1899:
1895:
1891:
1886:
1881:
1877:
1873:
1870:(2): 617–22.
1869:
1865:
1861:
1856:
1852:
1848:
1843:
1838:
1834:
1830:
1826:
1822:
1818:
1813:
1809:
1805:
1801:
1797:
1793:
1789:
1785:
1781:
1775:
1771:
1767:
1763:
1759:
1755:
1751:
1746:
1742:
1738:
1734:
1730:
1725:
1720:
1716:
1712:
1708:
1703:
1699:
1695:
1690:
1685:
1681:
1677:
1673:
1669:
1665:
1660:
1656:
1652:
1647:
1642:
1638:
1634:
1630:
1625:
1624:
1619:
1610:
1606:
1602:
1598:
1594:
1590:
1587:(2): 959–65.
1586:
1582:
1574:
1571:
1566:
1562:
1557:
1552:
1548:
1544:
1540:
1536:
1532:
1525:
1522:
1517:
1513:
1509:
1505:
1501:
1497:
1489:
1487:
1485:
1481:
1476:
1472:
1467:
1462:
1458:
1454:
1450:
1446:
1442:
1435:
1432:
1427:
1423:
1418:
1413:
1410:(2): 243–53.
1409:
1405:
1401:
1394:
1392:
1388:
1375:
1374:
1369:
1362:
1359:
1354:
1348:
1345:
1340:
1336:
1332:
1328:
1324:
1320:
1313:
1310:
1305:
1301:
1295:
1292:
1287:
1283:
1277:
1274:
1270:
1266:
1261:
1259:
1257:
1253:
1249:
1245:
1240:
1238:
1236:
1232:
1225:
1221:
1218:
1215:
1212:
1209:
1206:
1203:
1200:
1197:
1194:
1193:
1192:
1190:
1182:
1179:
1174:
1172:
1164:
1162:
1160:
1157:
1153:
1149:
1137:
1132:
1128:
1124:
1121:
1117:
1110:
1108:
1105:
1101:
1097:
1093:
1090:
1086:
1082:
1075:
1073:
1067:
1063:
1060:
1054:
1052:
1046:
1042:
1039:
1035:
1028:
1026:
1020:
1016:
1013:
1007:
1005:
999:
995:
992:
990:RefSeq (mRNA)
988:
981:
980:
975:
971:
968:
962:
961:
956:
952:
949:
947:
943:
936:
935:
930:
926:
923:
917:
916:
911:
907:
904:
902:
898:
891:
890:
885:
881:
878:
872:
871:
866:
862:
859:
857:
853:
850:
847:
845:
842:
838:
835:
831:
827:
820:
816:
811:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
676:
674:
671:
670:
664:
661:
659:
656:
654:
651:
650:
648:
645:
644:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
613:
610:
608:
605:
604:
602:
599:
598:
595:
594:Gene ontology
591:
587:
575:
570:
566:
561:
558:
556:
552:
544:
539:
528:
524:
521:sphenoid bone
520:
516:
512:
508:
504:
500:
496:
492:
491:
488:
484:
479:
476:
467:kidney tubule
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
429:
426:
422:
417:
414:
413:
410:
408:
404:
402:
401:
397:
396:
393:
391:
387:
383:
379:
375:
367:
362:
358:
354:
349:
339:
335:
328:
321:
315:
308:
300:
296:
292:
287:
283:
278:
274:
266:
261:
257:
253:
248:
238:
234:
227:
220:
214:
207:
203:
197:
193:
189:
184:
180:
175:
171:
167:
163:
159:
155:
151:
147:
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118:
111:
106:
101:
90:
88:
84:
80:
74:
69:
66:
65:
61:
58:
51:
47:
42:
38:
34:
29:
24:
21:
16:
3455:Translocases
3452:
3439:
3426:
3413:
3400:
3390:Transferases
3387:
3374:
3231:Binding site
3012:}}
3006:{{
2970:Endonuclease
2901:ribonuclease
2841:
2624:Nucleotidase
2545:Thioesterase
2310:
2307:J. Neurochem
2306:
2278:
2274:
2237:
2233:
2203:(1): 111–8.
2200:
2196:
2161:
2157:
2120:
2116:
2094:(3): 635–9.
2091:
2087:
2060:
2056:
2019:
2015:
1988:
1984:
1945:
1941:
1910:
1906:
1867:
1863:
1824:
1820:
1783:
1779:
1753:
1750:Biochemistry
1749:
1714:
1710:
1671:
1667:
1636:
1632:
1584:
1580:
1573:
1538:
1534:
1524:
1499:
1496:Cell. Signal
1495:
1451:(1): 51–63.
1448:
1444:
1434:
1407:
1403:
1378:. Retrieved
1371:
1361:
1347:
1325:(2): 504–7.
1322:
1318:
1312:
1303:
1294:
1285:
1276:
1186:
1183:Interactions
1176:
1168:
1155:
1147:
1146:
1069:
1048:
1022:
1001:
977:
958:
932:
913:
887:
868:
848:
843:
405:
398:
364:118,361,881
351:118,225,030
125:External IDs
76:
20:
15:
3226:Active site
3145:Nuclease S1
2916:Exonuclease
2810:Lecithinase
2639:Calcineurin
2577:Phosphatase
2483:Lipoprotein
2473:Endothelial
1717:(1): 31–5.
1445:J. Exp. Med
1380:January 29,
513:bone marrow
497:granulocyte
455:granulocyte
263:81,962,685
250:81,739,097
103:Identifiers
3498:Categories
3429:Isomerases
3403:Hydrolases
3270:Regulation
2458:Pancreatic
2395:Carboxylic
1864:Biochem. J
1639:(1): 1–3.
1581:J. Immunol
1271:, May 2017
1250:, May 2017
1226:References
431:glomerulus
409:(ortholog)
146:HomoloGene
3308:EC number
3035:RNase III
2893:(includes
2834:Sulfatase
2747:Autotaxin
2611:Prostatic
2463:Lysosomal
2378:esterases
2374:Hydrolase
2016:FEBS Lett
1711:FEBS Lett
1072:NP_758489
1051:NP_002652
1025:NM_172285
1004:NM_002661
834:Orthologs
154:GeneCards
3509:EC 3.1.4
3332:Kinetics
3256:Cofactor
3219:Activity
3129:RNase T1
2891:Nuclease
2526:Cutinase
2335:25410140
2327:10501179
2297:10469124
2262:19801963
2254:10467411
2234:Oncogene
2225:23174724
2217:10025672
2145:19529677
2044:85872860
1985:Immunity
1808:20562627
1741:20986590
1655:10933389
1633:Immunity
1609:19134463
1601:10623845
1516:12135708
1475:12093870
1426:10981967
1404:Immunity
1319:Genomics
1267:–
1246:–
1189:interact
1165:Function
1120:Wikidata
813:Sources:
463:appendix
3488:Biology
3442:Ligases
3212:Enzymes
3102:RNase E
3097:RNase Z
3092:RNase A
3087:RNase P
3060:RNase H
2678:Phytase
2478:Hepatic
2453:Lingual
2449:Gastric
2188:9819383
2137:9730685
2108:9398617
2079:9278385
2036:8980110
2007:8885868
1972:8395016
1929:8226808
1894:8093016
1885:1137272
1851:7682059
1800:7589147
1770:7578066
1733:2849563
1698:1979339
1565:8395016
1466:2194016
1339:7835906
1269:Ensembl
1248:Ensembl
946:UniProt
901:Ensembl
840:Species
819:QuickGO
653:cytosol
384:pattern
242:16q23.3
110:Aliases
3474:Portal
3416:Lyases
3040:Drosha
2965:3.1.21
2933:RecBCD
2911:3.1.11
2531:PETase
2439:Lipase
2333:
2325:
2295:
2260:
2252:
2223:
2215:
2186:
2179:109278
2176:
2143:
2135:
2106:
2077:
2042:
2034:
2005:
1970:
1963:360336
1960:
1927:
1892:
1882:
1849:
1842:298050
1839:
1806:
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1739:
1731:
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1689:329852
1686:
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1607:
1599:
1563:
1556:360336
1553:
1514:
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1463:
1424:
1337:
1216:, and
1214:PTPN11
1191:with:
1152:enzyme
1150:is an
1106:search
1104:PubMed
979:Q8CIH5
960:P16885
889:234779
856:Entrez
555:BioGPS
509:spleen
451:spleen
134:600220
3368:Types
3049:Dicer
3004:;see
2830:3.1.6
2800:PDE4B
2796:PDE4A
2734:3.1.4
2703:IMPA3
2699:IMPA2
2695:IMPA1
2573:3.1.3
2541:3.1.2
2391:3.1.1
2331:S2CID
2258:S2CID
2221:S2CID
2141:S2CID
2040:S2CID
1804:S2CID
1737:S2CID
1605:S2CID
1169:From
1156:PLCG2
849:Mouse
844:Human
815:Amigo
517:blood
439:blood
407:Mouse
400:Human
347:Start
282:Mouse
246:Start
179:Human
158:PLCG2
150:55671
142:97616
117:PLCG2
26:PLCG2
3460:list
3453:EC7
3447:list
3440:EC6
3434:list
3427:EC5
3421:list
3414:EC4
3408:list
3401:EC3
3395:list
3388:EC2
3382:list
3375:EC1
2967:-31:
2913:-16:
2899:and
2805:PDE5
2791:PDE3
2786:PDE2
2781:PDE1
2673:PTEN
2658:OCRL
2651:PP2A
2600:ALPP
2595:ALPL
2590:ALPI
2384:3.1)
2323:PMID
2293:PMID
2250:PMID
2213:PMID
2184:PMID
2133:PMID
2104:PMID
2075:PMID
2032:PMID
2003:PMID
1968:PMID
1925:PMID
1890:PMID
1847:PMID
1796:PMID
1766:PMID
1729:PMID
1694:PMID
1651:PMID
1597:PMID
1561:PMID
1512:PMID
1471:PMID
1422:PMID
1382:2023
1373:OMIM
1335:PMID
1220:SHC1
1202:GAB2
1171:OMIM
1159:gene
870:5336
390:Bgee
338:Band
299:Chr.
237:Band
196:Chr.
130:OMIM
87:2W2X
83:2W2W
79:2K2J
60:RCSB
57:PDBe
3122:4/5
2315:doi
2283:doi
2279:263
2242:doi
2205:doi
2174:PMC
2166:doi
2125:doi
2096:doi
2092:240
2065:doi
2061:272
2024:doi
2020:399
1993:doi
1958:PMC
1950:doi
1915:doi
1911:268
1880:PMC
1872:doi
1868:302
1837:PMC
1829:doi
1825:191
1788:doi
1758:doi
1719:doi
1715:242
1684:PMC
1676:doi
1641:doi
1589:doi
1585:164
1551:PMC
1543:doi
1504:doi
1461:PMC
1453:doi
1449:196
1412:doi
1327:doi
1208:LYN
360:End
259:End
162:OMA
138:MGI
50:PDB
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3080:2C
3075:2B
3070:2A
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3042::
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