242:
219:
116:
141:
493:
248:
147:
2837:
2857:
1459:
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999).
1151:. It is a single-pass type II membrane protein and is a multifunctional enzyme with both triacylglycerol lipase and acylglycerol O-acyltransferase activities. It is involved in the triacylglycerol hydrolysis in adipocytes and may play a role in energy metabolism.
1167:
and variations in this gene has been confirmed. A mutation of isoleucine to methionine (I>M) SNP rs738409 has been confirmed to increase susceptibility to non-alcoholic liver disease and also to have effects in diabetes.
1154:
The mature protein is 481 amino acids in length and the predicted molecular weight is 52.865 kilodaltons (kDa). Two of the isoforms have been described, but the functional significance (if any) of these forms is not known.
1583:"Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities"
255:
154:
791:
772:
77:
2931:
1911:
1616:
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005).
2902:
2158:
1245:
2921:
1227:
2072:
241:
2173:
2167:
1968:
1718:
2016:
1007:
1014:
218:
2556:
2127:
1916:
1306:"Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions"
1354:
1112:. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.
2234:
2122:
1214:
1193:
1139:. It is not known at present whether any of these transcriptions factors are actually involved in the regulation of this gene.
2043:
1953:
1906:
140:
115:
2712:
1210:
1546:
Liu YM, Moldes M, Bastard JP, Bruckert E, Viguerie N, Hainque B, Basdevant A, Langin D, Pairault J, Clément K (June 2004).
2465:
2406:
2827:
1189:
2510:
2077:
2067:
57:
2470:
2362:
1987:
254:
153:
2895:
2056:
2052:
2048:
1964:
1797:
1127:
Upstream of the gene, putative binding sites for several transcription factors have been identified. These include
247:
146:
2697:
1661:
Lake AC, Sun Y, Li JL, Kim JE, Johnson JW, Li D, Revett T, Shih HH, Liu W, Paulsen JE, Gimeno RE (November 2005).
2813:
2800:
2787:
2774:
2761:
2748:
2735:
2318:
2264:
2224:
2183:
2087:
1926:
1894:
1780:
1744:
2707:
2661:
2604:
1972:
1821:
1735:
836:
65:
2609:
1841:
1711:
817:
1503:
Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, Bye JM, Beare DM, Dunham I (January 2003).
2397:
2036:
2888:
2630:
2549:
2332:
2229:
2021:
1982:
1846:
1768:
129:
2702:
2515:
2350:
2345:
2278:
1938:
1763:
1473:
44:
2666:
2370:
2340:
2144:
2139:
2063:
1999:
1785:
990:
986:
982:
978:
2599:
2503:
2355:
1836:
1826:
1704:
1436:
1393:
89:
974:
953:
927:
906:
492:
2926:
2304:
2249:
2217:
2092:
1811:
1684:
1649:
1604:
1569:
1534:
1491:
1428:
1385:
1333:
1286:
37:
2872:
1124:
at band 13.31 (22q13.31). It lies on the Watson (plus) strand and is 40,750 bases in length.
2645:
2640:
2614:
2542:
2380:
1960:
1865:
1860:
1816:
1674:
1639:
1629:
1594:
1559:
1524:
1516:
1481:
1420:
1377:
1323:
1313:
1276:
334:
265:
209:
164:
85:
1663:"Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members"
2692:
2676:
2589:
2482:
2296:
2212:
2207:
2202:
2115:
2110:
1870:
1748:
1105:
309:
1477:
2841:
2730:
2671:
2455:
2450:
2445:
1831:
1806:
1802:
1775:
1758:
1328:
1305:
1164:
1644:
1617:
1529:
1504:
1368:
Stickel F, Hampe J (January 2012). "Genetic determinants of alcoholic liver disease".
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
630:
625:
620:
615:
610:
594:
589:
584:
579:
574:
569:
564:
559:
554:
549:
544:
539:
534:
2915:
2868:
2635:
2594:
2196:
2105:
1855:
1121:
521:
1440:
1397:
69:
2584:
2323:
2254:
1977:
1898:
1505:"Reevaluating human gene annotation: a second-generation analysis of chromosome 22"
327:
106:
1424:
93:
2808:
2743:
2579:
2498:
2269:
2163:
2026:
1992:
1930:
1696:
1250:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1232:
National Center for
Biotechnology Information, U.S. National Library of Medicine
48:, ADPN, C22orf20, iPLA(2)epsilon, patatin like phospholipase domain containing 3
2836:
1679:
1662:
1381:
1318:
1281:
1264:
410:
2475:
1411:
Pingitore P, Romeo S (June 2019). "The role of PNPLA3 in health and disease".
1128:
226:
123:
73:
1634:
1548:"Adiponutrin: A new gene regulated by energy balance in human adipose tissue"
2782:
2756:
2388:
2187:
2100:
1727:
1581:
Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B, Gross RW (November 2004).
1263:
Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (September 2006).
1109:
736:
470:
348:
293:
280:
192:
179:
81:
1688:
1653:
1608:
1599:
1582:
1573:
1564:
1547:
1538:
1495:
1432:
1389:
1337:
1290:
1413:
Biochimica et
Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
1054:
1049:
2433:
2428:
2423:
2244:
1879:
1731:
1038:
881:
862:
2440:
2418:
2413:
2031:
848:
803:
1520:
2795:
2565:
2460:
2393:
2286:
1884:
1792:
1132:
1101:
1082:
1022:
758:
2856:
1355:"Entrez Gene: PNPLA3 patatin-like phospholipase domain containing 3"
1486:
1461:
2769:
2402:
2153:
2149:
1618:"A genome annotation-driven approach to cloning the human ORFeome"
1136:
1265:"Characterization of the human patatin-like phospholipase family"
721:
717:
2864:
2134:
2011:
2004:
1948:
1943:
1089:
501:
61:
2538:
1700:
1304:
Kienesberger PC, Oberer M, Lass A, Zechner R (April 2009).
2534:
317:
2876:
1149:
patatin-like phospholipase domain-containing protein 3
1067:
Patatin-like phospholipase domain-containing protein 3
2825:
595:
1-acylglycerol-3-phosphate O-acyltransferase activity
482:
1552:
The
Journal of Clinical Endocrinology and Metabolism
2721:
2685:
2654:
2623:
2572:
2491:
2379:
2331:
2317:
2295:
2277:
2263:
2243:
2182:
2086:
1925:
1893:
1743:
967:
946:
920:
899:
1206:
1204:
1202:
1185:
1183:
1181:
1163:An association between alcoholic liver disease in
2022:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
264:
163:
16:Protein-coding gene in the species Homo sapiens
1211:GRCm38: Ensembl release 89: ENSMUSG00000041653
590:lysophosphatidic acid acyltransferase activity
2896:
2550:
1712:
1147:The recommended name for the gene product is
8:
1079:calcium-independent phospholipase A2-epsilon
1190:GRCh38: Ensembl release 89: ENSG00000100344
2903:
2889:
2557:
2543:
2535:
2328:
2274:
2260:
1719:
1705:
1697:
732:
517:
305:
204:
101:
1678:
1643:
1633:
1598:
1563:
1528:
1485:
1462:"The DNA sequence of human chromosome 22"
1327:
1317:
1280:
1349:
1347:
2832:
1912:Ubiquitin carboxy-terminal hydrolase L1
1177:
1120:The gene is located on the long arm of
687:long-chain fatty acid metabolic process
565:acylglycerol O-acyltransferase activity
697:phosphatidic acid biosynthetic process
18:
2492:either deoxy- or ribo-
692:glycerophospholipid metabolic process
269:
230:
225:
168:
127:
122:
7:
2853:
2851:
2073:Protein serine/threonine phosphatase
2174:Cyclic nucleotide phosphodiesterase
2168:Clostridium perfringens alpha toxin
1969:Tartrate-resistant acid phosphatase
1587:The Journal of Biological Chemistry
2875:. You can help Knowledge (XXG) by
2017:Pyruvate dehydrogenase phosphatase
964:
943:
917:
896:
872:
853:
827:
808:
782:
763:
677:triglyceride acyl-chain remodeling
662:acylglycerol acyl-chain remodeling
535:mono-olein transacylation activity
487:
405:
343:
322:
14:
1917:4-hydroxybenzoyl-CoA thioesterase
1100:Adiponutrin is a triacylglycerol
1085:that in humans is encoded by the
707:phospholipid biosynthetic process
652:triglyceride biosynthetic process
585:long-chain fatty acyl-CoA binding
2855:
2835:
491:
253:
246:
240:
217:
152:
145:
139:
114:
2235:N-acetylglucosamine-6-sulfatase
2123:Sphingomyelin phosphodiesterase
560:diolein transacylation activity
2932:Human chromosome 22 gene stubs
2044:Inositol-phosphate phosphatase
1907:Palmitoyl protein thioesterase
1075:acylglycerol O-acyltransferase
672:triglyceride catabolic process
616:endoplasmic reticulum membrane
611:integral component of membrane
502:More reference expression data
471:More reference expression data
1:
2407:RNA-induced silencing complex
580:lysophosphatidic acid binding
238:
137:
2922:Genes on human chromosome 22
2511:Serratia marcescens nuclease
2078:Dual-specificity phosphatase
2068:Protein tyrosine phosphatase
1425:10.1016/j.bbalip.2018.06.018
575:triglyceride lipase activity
1988:Fructose 1,6-bisphosphatase
1312:. 50 Suppl (Suppl): S63-8.
570:lipoprotein lipase activity
2948:
2850:
1680:10.1194/jlr.M500290-JLR200
1382:10.1136/gutjnl-2011-301239
1319:10.1194/jlr.R800082-JLR200
1282:10.1194/jlr.M600185-JLR200
702:lipid droplet organization
359:retinal pigment epithelium
2713:Michaelis–Menten kinetics
2225:Galactosamine-6 sulfatase
1781:6-phosphogluconolactonase
1667:Journal of Lipid Research
1310:Journal of Lipid Research
1269:Journal of Lipid Research
1246:"Mouse PubMed Reference:"
1228:"Human PubMed Reference:"
1053:
1048:
1044:
1037:
1021:
1002:
971:
950:
939:
924:
903:
892:
879:
875:
860:
856:
847:
834:
830:
815:
811:
802:
789:
785:
770:
766:
757:
742:
735:
731:
715:
545:phospholipase A2 activity
520:
516:
499:
490:
481:
468:
453:quadriceps femoris muscle
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
2605:Diffusion-limited enzyme
1973:Purple acid phosphatases
1635:10.1186/gb-2004-5-10-r84
1069:(PNPLA3), also known as
1015:Chr 15: 84.05 – 84.07 Mb
1008:Chr 22: 43.92 – 43.96 Mb
550:acyltransferase activity
1081:(iPLA2-epsilon) is an
647:lipid catabolic process
2398:Microprocessor complex
2037:Beta-propeller phytase
1600:10.1074/jbc.M407841200
1565:10.1210/jc.2003-031978
445:skeletal muscle tissue
425:neural layer of retina
2698:Eadie–Hofstee diagram
2631:Allosteric regulation
2333:Endodeoxyribonuclease
2230:Iduronate-2-sulfatase
1983:Glucose 6-phosphatase
1769:Butyrylcholinesterase
395:middle temporal gyrus
232:Chromosome 15 (mouse)
130:Chromosome 22 (human)
2708:Lineweaver–Burk plot
2516:Micrococcal nuclease
2351:Deoxyribonuclease IV
2346:Deoxyribonuclease II
2279:Exodeoxyribonuclease
1939:Alkaline phosphatase
1764:Acetylcholinesterase
540:transferase activity
421:white adipose tissue
2371:UvrABC endonuclease
2341:Deoxyribonuclease I
2064:Protein phosphatase
2000:Protein phosphatase
1798:Bile salt-dependent
1786:PAF acetylhydrolase
1478:1999Natur.402..489D
367:right lobe of liver
2863:This article on a
2667:Enzyme superfamily
2600:Enzyme promiscuity
2504:Mung bean nuclease
2363:Restriction enzyme
2356:Restriction enzyme
1159:Clinical relevance
837:ENSMUSG00000041653
640:Biological process
604:Cellular component
555:hydrolase activity
528:Molecular function
363:buccal mucosa cell
94:PNPLA3 - orthologs
2884:
2883:
2823:
2822:
2532:
2531:
2528:
2527:
2524:
2523:
2313:
2312:
2305:Oligonucleotidase
2250:deoxyribonuclease
2218:Steroid sulfatase
2093:Phosphodiesterase
1822:Hormone-sensitive
1521:10.1101/gr.695703
1064:
1063:
1060:
1059:
1033:
1032:
998:
997:
961:
960:
935:
934:
914:
913:
888:
887:
869:
868:
843:
842:
824:
823:
798:
797:
779:
778:
727:
726:
682:lipid homeostasis
512:
511:
508:
507:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
2939:
2905:
2898:
2891:
2859:
2852:
2840:
2839:
2831:
2703:Hanes–Woolf plot
2646:Enzyme activator
2641:Enzyme inhibitor
2615:Enzyme catalysis
2559:
2552:
2545:
2536:
2381:Endoribonuclease
2367:
2361:
2329:
2275:
2261:
1961:Acid phosphatase
1842:Monoacylglycerol
1752:ester hydrolases
1721:
1714:
1707:
1698:
1692:
1682:
1657:
1647:
1637:
1612:
1602:
1593:(47): 48968–75.
1577:
1567:
1542:
1532:
1499:
1489:
1472:(6761): 489–95.
1445:
1444:
1408:
1402:
1401:
1365:
1359:
1358:
1351:
1342:
1341:
1331:
1321:
1301:
1295:
1294:
1284:
1260:
1254:
1253:
1242:
1236:
1235:
1224:
1218:
1208:
1197:
1187:
1046:
1045:
1017:
1010:
993:
965:
956:
944:
940:RefSeq (protein)
930:
918:
909:
897:
873:
854:
828:
809:
783:
764:
733:
667:lipid metabolism
518:
504:
495:
488:
473:
413:
411:Top expressed in
406:
371:secondary oocyte
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
2947:
2946:
2942:
2941:
2940:
2938:
2937:
2936:
2912:
2911:
2910:
2909:
2848:
2846:
2834:
2826:
2824:
2819:
2731:Oxidoreductases
2717:
2693:Enzyme kinetics
2681:
2677:List of enzymes
2650:
2619:
2590:Catalytic triad
2568:
2563:
2533:
2520:
2487:
2375:
2365:
2359:
2322:
2309:
2297:Exoribonuclease
2291:
2268:
2252:
2248:
2239:
2213:Arylsulfatase L
2208:Arylsulfatase B
2203:Arylsulfatase A
2178:
2091:
2082:
1921:
1889:
1751:
1739:
1725:
1695:
1673:(11): 2477–87.
1660:
1615:
1580:
1545:
1509:Genome Research
1502:
1458:
1454:
1452:Further reading
1449:
1448:
1410:
1409:
1405:
1367:
1366:
1362:
1353:
1352:
1345:
1303:
1302:
1298:
1262:
1261:
1257:
1244:
1243:
1239:
1226:
1225:
1221:
1209:
1200:
1188:
1179:
1174:
1161:
1145:
1118:
1106:triacylglycerol
1098:
1055:View/Edit Mouse
1050:View/Edit Human
1013:
1006:
1003:Location (UCSC)
989:
985:
981:
977:
973:
952:
926:
905:
818:ENSG00000100344
711:
635:
599:
500:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
391:skin of abdomen
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
2945:
2943:
2935:
2934:
2929:
2924:
2914:
2913:
2908:
2907:
2900:
2893:
2885:
2882:
2881:
2860:
2845:
2844:
2821:
2820:
2818:
2817:
2804:
2791:
2778:
2765:
2752:
2739:
2725:
2723:
2719:
2718:
2716:
2715:
2710:
2705:
2700:
2695:
2689:
2687:
2683:
2682:
2680:
2679:
2674:
2669:
2664:
2658:
2656:
2655:Classification
2652:
2651:
2649:
2648:
2643:
2638:
2633:
2627:
2625:
2621:
2620:
2618:
2617:
2612:
2607:
2602:
2597:
2592:
2587:
2582:
2576:
2574:
2570:
2569:
2564:
2562:
2561:
2554:
2547:
2539:
2530:
2529:
2526:
2525:
2522:
2521:
2519:
2518:
2513:
2508:
2507:
2506:
2495:
2493:
2489:
2488:
2486:
2485:
2480:
2479:
2478:
2473:
2468:
2463:
2453:
2448:
2443:
2438:
2437:
2436:
2431:
2426:
2421:
2411:
2410:
2409:
2400:
2385:
2383:
2377:
2376:
2374:
2373:
2368:
2353:
2348:
2343:
2337:
2335:
2326:
2315:
2314:
2311:
2310:
2308:
2307:
2301:
2299:
2293:
2292:
2290:
2289:
2283:
2281:
2272:
2258:
2241:
2240:
2238:
2237:
2232:
2227:
2222:
2221:
2220:
2215:
2210:
2205:
2192:
2190:
2180:
2179:
2177:
2176:
2171:
2161:
2156:
2147:
2142:
2137:
2132:
2131:
2130:
2120:
2119:
2118:
2113:
2103:
2097:
2095:
2084:
2083:
2081:
2080:
2075:
2070:
2061:
2060:
2059:
2041:
2040:
2039:
2029:
2024:
2019:
2014:
2009:
2008:
2007:
1997:
1996:
1995:
1985:
1980:
1975:
1958:
1957:
1956:
1951:
1946:
1935:
1933:
1923:
1922:
1920:
1919:
1914:
1909:
1903:
1901:
1891:
1890:
1888:
1887:
1882:
1876:
1875:
1874:
1873:
1868:
1863:
1852:
1851:
1850:
1849:
1847:Diacylglycerol
1844:
1839:
1834:
1829:
1824:
1819:
1814:
1809:
1800:
1789:
1788:
1783:
1778:
1776:Pectinesterase
1773:
1772:
1771:
1766:
1759:Cholinesterase
1755:
1753:
1741:
1740:
1726:
1724:
1723:
1716:
1709:
1701:
1694:
1693:
1658:
1622:Genome Biology
1613:
1578:
1543:
1500:
1487:10.1038/990031
1455:
1453:
1450:
1447:
1446:
1419:(6): 900–906.
1403:
1360:
1343:
1296:
1255:
1237:
1219:
1198:
1176:
1175:
1173:
1170:
1160:
1157:
1144:
1141:
1117:
1114:
1108:hydrolysis in
1104:that mediates
1097:
1094:
1062:
1061:
1058:
1057:
1052:
1042:
1041:
1035:
1034:
1031:
1030:
1028:
1026:
1019:
1018:
1011:
1004:
1000:
999:
996:
995:
969:
968:
962:
959:
958:
948:
947:
941:
937:
936:
933:
932:
922:
921:
915:
912:
911:
901:
900:
894:
890:
889:
886:
885:
877:
876:
870:
867:
866:
858:
857:
851:
845:
844:
841:
840:
832:
831:
825:
822:
821:
813:
812:
806:
800:
799:
796:
795:
787:
786:
780:
777:
776:
768:
767:
761:
755:
754:
749:
744:
740:
739:
729:
728:
725:
724:
713:
712:
710:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
643:
641:
637:
636:
634:
633:
628:
623:
618:
613:
607:
605:
601:
600:
598:
597:
592:
587:
582:
577:
572:
567:
562:
557:
552:
547:
542:
537:
531:
529:
525:
524:
514:
513:
510:
509:
506:
505:
497:
496:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2944:
2933:
2930:
2928:
2925:
2923:
2920:
2919:
2917:
2906:
2901:
2899:
2894:
2892:
2887:
2886:
2880:
2878:
2874:
2870:
2869:chromosome 22
2866:
2861:
2858:
2854:
2849:
2843:
2838:
2833:
2829:
2815:
2811:
2810:
2805:
2802:
2798:
2797:
2792:
2789:
2785:
2784:
2779:
2776:
2772:
2771:
2766:
2763:
2759:
2758:
2753:
2750:
2746:
2745:
2740:
2737:
2733:
2732:
2727:
2726:
2724:
2720:
2714:
2711:
2709:
2706:
2704:
2701:
2699:
2696:
2694:
2691:
2690:
2688:
2684:
2678:
2675:
2673:
2672:Enzyme family
2670:
2668:
2665:
2663:
2660:
2659:
2657:
2653:
2647:
2644:
2642:
2639:
2637:
2636:Cooperativity
2634:
2632:
2629:
2628:
2626:
2622:
2616:
2613:
2611:
2608:
2606:
2603:
2601:
2598:
2596:
2595:Oxyanion hole
2593:
2591:
2588:
2586:
2583:
2581:
2578:
2577:
2575:
2571:
2567:
2560:
2555:
2553:
2548:
2546:
2541:
2540:
2537:
2517:
2514:
2512:
2509:
2505:
2502:
2501:
2500:
2497:
2496:
2494:
2490:
2484:
2481:
2477:
2474:
2472:
2469:
2467:
2464:
2462:
2459:
2458:
2457:
2454:
2452:
2449:
2447:
2444:
2442:
2439:
2435:
2432:
2430:
2427:
2425:
2422:
2420:
2417:
2416:
2415:
2412:
2408:
2404:
2401:
2399:
2395:
2392:
2391:
2390:
2387:
2386:
2384:
2382:
2378:
2372:
2369:
2364:
2357:
2354:
2352:
2349:
2347:
2344:
2342:
2339:
2338:
2336:
2334:
2330:
2327:
2325:
2320:
2316:
2306:
2303:
2302:
2300:
2298:
2294:
2288:
2285:
2284:
2282:
2280:
2276:
2273:
2271:
2266:
2262:
2259:
2256:
2251:
2246:
2242:
2236:
2233:
2231:
2228:
2226:
2223:
2219:
2216:
2214:
2211:
2209:
2206:
2204:
2201:
2200:
2199:
2198:
2197:arylsulfatase
2194:
2193:
2191:
2189:
2185:
2181:
2175:
2172:
2169:
2165:
2162:
2160:
2157:
2155:
2151:
2148:
2146:
2143:
2141:
2138:
2136:
2133:
2129:
2126:
2125:
2124:
2121:
2117:
2114:
2112:
2109:
2108:
2107:
2106:Phospholipase
2104:
2102:
2099:
2098:
2096:
2094:
2089:
2085:
2079:
2076:
2074:
2071:
2069:
2065:
2062:
2058:
2054:
2050:
2047:
2046:
2045:
2042:
2038:
2035:
2034:
2033:
2030:
2028:
2025:
2023:
2020:
2018:
2015:
2013:
2010:
2006:
2003:
2002:
2001:
1998:
1994:
1991:
1990:
1989:
1986:
1984:
1981:
1979:
1976:
1974:
1970:
1966:
1962:
1959:
1955:
1952:
1950:
1947:
1945:
1942:
1941:
1940:
1937:
1936:
1934:
1932:
1928:
1924:
1918:
1915:
1913:
1910:
1908:
1905:
1904:
1902:
1900:
1896:
1892:
1886:
1883:
1881:
1878:
1877:
1872:
1869:
1867:
1864:
1862:
1859:
1858:
1857:
1856:Phospholipase
1854:
1853:
1848:
1845:
1843:
1840:
1838:
1835:
1833:
1830:
1828:
1825:
1823:
1820:
1818:
1815:
1813:
1810:
1808:
1804:
1801:
1799:
1796:
1795:
1794:
1791:
1790:
1787:
1784:
1782:
1779:
1777:
1774:
1770:
1767:
1765:
1762:
1761:
1760:
1757:
1756:
1754:
1750:
1746:
1742:
1737:
1733:
1729:
1722:
1717:
1715:
1710:
1708:
1703:
1702:
1699:
1690:
1686:
1681:
1676:
1672:
1668:
1664:
1659:
1655:
1651:
1646:
1641:
1636:
1631:
1627:
1623:
1619:
1614:
1610:
1606:
1601:
1596:
1592:
1588:
1584:
1579:
1575:
1571:
1566:
1561:
1558:(6): 2684–9.
1557:
1553:
1549:
1544:
1540:
1536:
1531:
1526:
1522:
1518:
1514:
1510:
1506:
1501:
1497:
1493:
1488:
1483:
1479:
1475:
1471:
1467:
1463:
1457:
1456:
1451:
1442:
1438:
1434:
1430:
1426:
1422:
1418:
1414:
1407:
1404:
1399:
1395:
1391:
1387:
1383:
1379:
1375:
1371:
1364:
1361:
1356:
1350:
1348:
1344:
1339:
1335:
1330:
1325:
1320:
1315:
1311:
1307:
1300:
1297:
1292:
1288:
1283:
1278:
1275:(9): 1940–9.
1274:
1270:
1266:
1259:
1256:
1251:
1247:
1241:
1238:
1233:
1229:
1223:
1220:
1216:
1212:
1207:
1205:
1203:
1199:
1195:
1191:
1186:
1184:
1182:
1178:
1171:
1169:
1166:
1158:
1156:
1152:
1150:
1142:
1140:
1138:
1134:
1130:
1125:
1123:
1122:chromosome 22
1115:
1113:
1111:
1107:
1103:
1095:
1093:
1091:
1088:
1084:
1080:
1076:
1072:
1068:
1056:
1051:
1047:
1043:
1040:
1036:
1029:
1027:
1024:
1020:
1016:
1012:
1009:
1005:
1001:
994:
992:
988:
984:
980:
976:
970:
966:
963:
957:
955:
949:
945:
942:
938:
931:
929:
923:
919:
916:
910:
908:
902:
898:
895:
893:RefSeq (mRNA)
891:
884:
883:
878:
874:
871:
865:
864:
859:
855:
852:
850:
846:
839:
838:
833:
829:
826:
820:
819:
814:
810:
807:
805:
801:
794:
793:
788:
784:
781:
775:
774:
769:
765:
762:
760:
756:
753:
750:
748:
745:
741:
738:
734:
730:
723:
719:
714:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
644:
642:
639:
638:
632:
629:
627:
626:lipid droplet
624:
622:
619:
617:
614:
612:
609:
608:
606:
603:
602:
596:
593:
591:
588:
586:
583:
581:
578:
576:
573:
571:
568:
566:
563:
561:
558:
556:
553:
551:
548:
546:
543:
541:
538:
536:
533:
532:
530:
527:
526:
523:
522:Gene ontology
519:
515:
503:
498:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
271:15|15 E2
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
2877:expanding it
2862:
2847:
2809:Translocases
2806:
2793:
2780:
2767:
2754:
2744:Transferases
2741:
2728:
2585:Binding site
2366:}}
2360:{{
2324:Endonuclease
2255:ribonuclease
2195:
1978:Nucleotidase
1899:Thioesterase
1670:
1666:
1625:
1621:
1590:
1586:
1555:
1551:
1515:(1): 27–36.
1512:
1508:
1469:
1465:
1416:
1412:
1406:
1376:(1): 150–9.
1373:
1369:
1363:
1309:
1299:
1272:
1268:
1258:
1249:
1240:
1231:
1222:
1162:
1153:
1148:
1146:
1143:Biochemistry
1126:
1119:
1099:
1086:
1078:
1074:
1070:
1066:
1065:
991:NP_001395271
987:NP_001395270
983:NP_001395269
979:NP_001395268
972:
951:
925:
904:
880:
861:
835:
816:
790:
771:
751:
746:
429:zone of skin
333:
326:
53:External IDs
2580:Active site
2499:Nuclease S1
2270:Exonuclease
2164:Lecithinase
1993:Calcineurin
1931:Phosphatase
1837:Lipoprotein
1827:Endothelial
1628:(10): R84.
1071:adiponutrin
379:skin of leg
292:84,071,437
279:84,052,038
191:43,964,488
178:43,923,792
31:Identifiers
2916:Categories
2783:Isomerases
2757:Hydrolases
2624:Regulation
1812:Pancreatic
1749:Carboxylic
1217:, May 2017
1196:, May 2017
1172:References
1165:caucasians
1129:PPAR-gamma
1110:adipocytes
657:metabolism
337:(ortholog)
74:HomoloGene
2867:on human
2662:EC number
2389:RNase III
2247:(includes
2188:Sulfatase
2101:Autotaxin
1965:Prostatic
1817:Lysosomal
1732:esterases
1728:Hydrolase
975:NP_473429
954:NP_079501
928:NM_054088
907:NM_025225
737:Orthologs
621:cytoplasm
449:left lung
433:esophagus
82:GeneCards
2927:EC 3.1.1
2686:Kinetics
2610:Cofactor
2573:Activity
2483:RNase T1
2245:Nuclease
1880:Cutinase
1689:16150821
1654:15461802
1609:15364929
1574:15181042
1539:12529303
1496:10591208
1441:49392249
1433:29935383
1398:22559086
1390:22110053
1338:19029121
1291:16799181
1213:–
1192:–
1116:Genomics
1096:Function
1073:(ADPN),
1039:Wikidata
716:Sources:
631:membrane
387:testicle
170:22q13.31
2842:Biology
2796:Ligases
2566:Enzymes
2456:RNase E
2451:RNase Z
2446:RNase A
2441:RNase P
2414:RNase H
2032:Phytase
1832:Hepatic
1807:Lingual
1803:Gastric
1474:Bibcode
1329:2674697
1215:Ensembl
1194:Ensembl
849:UniProt
804:Ensembl
743:Species
722:QuickGO
312:pattern
70:2151796
38:Aliases
2828:Portal
2770:Lyases
2394:Drosha
2319:3.1.21
2287:RecBCD
2265:3.1.11
1885:PETase
1793:Lipase
1687:
1652:
1645:545604
1642:
1607:
1572:
1537:
1530:430954
1527:
1494:
1466:Nature
1439:
1431:
1396:
1388:
1336:
1326:
1289:
1137:POU2F2
1135:, and
1133:POU2F1
1102:lipase
1087:PNPLA3
1083:enzyme
1025:search
1023:PubMed
882:Q91WW7
863:Q9NST1
792:116939
759:Entrez
483:BioGPS
457:morula
86:PNPLA3
62:609567
45:PNPLA3
22:PNPLA3
2871:is a
2722:Types
2403:Dicer
2358:;see
2184:3.1.6
2154:PDE4B
2150:PDE4A
2088:3.1.4
2057:IMPA3
2053:IMPA2
2049:IMPA1
1927:3.1.3
1895:3.1.2
1745:3.1.1
1437:S2CID
1394:S2CID
773:80339
752:Mouse
747:Human
718:Amigo
383:vulva
375:tibia
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:11883
2873:stub
2865:gene
2814:list
2807:EC7
2801:list
2794:EC6
2788:list
2781:EC5
2775:list
2768:EC4
2762:list
2755:EC3
2749:list
2742:EC2
2736:list
2729:EC1
2321:-31:
2267:-16:
2253:and
2159:PDE5
2145:PDE3
2140:PDE2
2135:PDE1
2027:PTEN
2012:OCRL
2005:PP2A
1954:ALPP
1949:ALPL
1944:ALPI
1738:3.1)
1685:PMID
1650:PMID
1605:PMID
1570:PMID
1535:PMID
1492:PMID
1429:PMID
1417:1864
1386:PMID
1334:PMID
1287:PMID
1090:gene
437:lens
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
2476:4/5
1675:doi
1640:PMC
1630:doi
1595:doi
1591:279
1560:doi
1525:PMC
1517:doi
1482:doi
1470:402
1421:doi
1378:doi
1370:Gut
1324:PMC
1314:doi
1277:doi
1077:or
441:lip
288:End
187:End
90:OMA
66:MGI
2918::
2434:2C
2429:2B
2424:2A
2405::
2396::
2186::
2066::
2055:,
2051:,
1967:)/
1929::
1897::
1866:A2
1861:A1
1747::
1736:EC
1730::
1683:.
1671:46
1669:.
1665:.
1648:.
1638:.
1624:.
1620:.
1603:.
1589:.
1585:.
1568:.
1556:89
1554:.
1550:.
1533:.
1523:.
1513:13
1511:.
1507:.
1490:.
1480:.
1468:.
1464:.
1435:.
1427:.
1415:.
1392:.
1384:.
1374:61
1372:.
1346:^
1332:.
1322:.
1308:.
1285:.
1273:47
1271:.
1267:.
1248:.
1230:.
1201:^
1180:^
1131:,
1092:.
720:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
2904:e
2897:t
2890:v
2879:.
2830::
2816:)
2812:(
2803:)
2799:(
2790:)
2786:(
2777:)
2773:(
2764:)
2760:(
2751:)
2747:(
2738:)
2734:(
2558:e
2551:t
2544:v
2471:3
2466:2
2461:1
2419:1
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