242:
219:
116:
141:
248:
147:
1002:
catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.
1001:
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a
1543:
Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, Wahlestedt C, Zabarovsky ER (Jul 2002).
1142:
Hu P, Yu L, Zhang M, Zheng L, Zhao Y, Fu Q, Zhao S (Jul 2000). "Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16".
1436:
Strack S, Zaucha JA, Ebner FF, Colbran RJ, Wadzinski BE (Mar 1998). "Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits".
1510:"HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25"
255:
154:
1097:
Torres R, Ide SE, Dehejia A, Baras A, Polymeropoulos MH (Oct 1999). "Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit".
672:
77:
653:
1079:
1061:
1667:
1449:
241:
927:
920:
218:
1180:
1048:
1027:
1044:
140:
115:
1403:"Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production"
1023:
57:
254:
153:
247:
146:
1199:
Zolnierowicz S (Oct 2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways".
717:
65:
698:
1106:
1337:
Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses".
129:
1111:
48:, B55-GAMMA, IMYPNO, IMYPNO1, PR52, PR55G, protein phosphatase 2 regulatory subunit Bgamma, B55gamma
44:
903:
878:
860:
856:
852:
832:
807:
789:
785:
781:
1461:
1389:
89:
899:
868:
864:
828:
797:
793:
1181:"Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform"
1645:
1610:
1575:
1531:
1496:
1453:
1424:
1381:
1346:
1325:
1290:
1245:
1216:
1159:
1124:
37:
85:
1635:
1600:
1587:
Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA (Oct 2003).
1565:
1557:
1521:
1486:
1445:
1414:
1371:
1315:
1280:
1270:
1237:
1208:
1151:
1116:
334:
265:
209:
164:
309:
1546:"NotI flanking sequences: a tool for gene discovery and verification of the human genome"
1360:"Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr"
1640:
1623:
1570:
1545:
1376:
1359:
1285:
1258:
1212:
587:
582:
577:
572:
556:
551:
535:
530:
525:
1661:
512:
1465:
1393:
69:
1473:
Sanger Centre, The; Washington
University Genome Sequencing Cente, The (Nov 1998).
327:
106:
1624:"Identification of specific PP2A complexes involved in human cell transformation"
980:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
93:
1084:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1066:
National Center for
Biotechnology Information, U.S. National Library of Medicine
410:
1622:
Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, Hahn WC (Feb 2004).
1228:
Andersen JL, Planelles V (Jan 2005). "The role of Vpr in HIV-1 pathogenesis".
226:
123:
73:
1241:
1120:
617:
470:
348:
293:
280:
192:
179:
81:
1649:
1614:
1605:
1588:
1579:
1535:
1526:
1509:
1450:
10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3
1419:
1402:
1350:
1329:
1294:
1275:
1249:
1220:
1163:
1155:
1128:
1500:
1457:
1428:
1385:
1320:
1303:
967:
962:
1561:
1491:
1474:
1358:
Tung HY, De
Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (Jan 1997).
951:
762:
743:
1589:"Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A"
1259:"The Vpr protein from HIV-1: distinct roles along the viral life cycle"
729:
684:
983:
935:
639:
602:
598:
990:
61:
1508:
Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001).
317:
482:
1401:Ruediger R, Brewis N, Ohst K, Walter G (Nov 1997).
892:
851:
821:
780:
433:
dentate gyrus of hippocampal formation granule cell
1040:
1038:
1036:
1019:
1017:
1015:
1304:"Viral infections and cell cycle G2/M regulation"
588:regulation of phosphoprotein phosphatase activity
264:
163:
16:Protein-coding gene in the species Homo sapiens
1045:GRCm38: Ensembl release 89: ENSMUSG00000029120
531:protein serine/threonine phosphatase activity
8:
1024:GRCh38: Ensembl release 89: ENSG00000074211
848:
777:
613:
508:
305:
204:
101:
1639:
1604:
1569:
1525:
1490:
1475:"Toward a complete human genome sequence"
1418:
1375:
1319:
1284:
1274:
1110:
1175:
1173:
1011:
1339:The Indian Journal of Medical Research
536:protein phosphatase regulator activity
18:
269:
230:
225:
168:
127:
122:
7:
1438:The Journal of Comparative Neurology
1593:The Journal of Biological Chemistry
552:protein phosphatase type 2A complex
889:
818:
753:
734:
708:
689:
663:
644:
487:
405:
343:
322:
14:
986:that in humans is encoded by the
578:peptidyl-serine dephosphorylation
1257:Le Rouzic E, Benichou S (2006).
253:
246:
240:
217:
152:
145:
139:
114:
1302:Zhao RY, Elder RT (Mar 2005).
471:More reference expression data
1:
1641:10.1016/S1535-6108(04)00026-1
1377:10.1016/S0014-5793(96)01470-6
1213:10.1016/S0006-2952(00)00424-X
238:
137:
1668:Genes on human chromosome 4
1684:
1080:"Mouse PubMed Reference:"
1062:"Human PubMed Reference:"
966:
961:
957:
950:
934:
915:
896:
875:
844:
825:
804:
773:
760:
756:
741:
737:
728:
715:
711:
696:
692:
683:
670:
666:
651:
647:
638:
623:
616:
612:
596:
511:
507:
495:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1242:10.2174/1570162052772988
1201:Biochemical Pharmacology
928:Chr 5: 37.03 – 37.11 Mb
1606:10.1074/jbc.M308678200
1550:Nucleic Acids Research
1527:10.1006/viro.2001.1007
1420:10.1006/viro.1997.8873
1276:10.1186/1742-4690-2-11
1156:10.1006/geno.2000.6219
1121:10.1093/dnares/6.5.323
425:superior frontal gyrus
367:superior frontal gyrus
1321:10.1038/sj.cr.7290279
921:Chr 4: 6.32 – 6.56 Mb
583:developmental process
429:primary visual cortex
391:primary visual cortex
359:middle temporal gyrus
1492:10.1101/gr.8.11.1097
1230:Current HIV Research
437:primary motor cortex
232:Chromosome 5 (mouse)
130:Chromosome 4 (human)
94:PPP2R2C - orthologs
1562:10.1093/nar/gkf428
718:ENSMUSG00000029120
573:mitotic cell cycle
566:Biological process
545:Cellular component
519:Molecular function
453:olfactory tubercle
977:
976:
973:
972:
946:
945:
911:
910:
886:
885:
840:
839:
815:
814:
769:
768:
750:
749:
724:
723:
705:
704:
679:
678:
660:
659:
608:
607:
503:
502:
499:
498:
477:
476:
464:
463:
457:cerebellar cortex
445:prefrontal cortex
402:
401:
395:prefrontal cortex
387:entorhinal cortex
375:postcentral gyrus
300:
299:
199:
198:
1675:
1653:
1643:
1618:
1608:
1599:(42): 40829–36.
1583:
1573:
1539:
1529:
1504:
1494:
1485:(11): 1097–108.
1469:
1432:
1422:
1397:
1379:
1370:(2–3): 197–201.
1354:
1333:
1323:
1298:
1288:
1278:
1253:
1224:
1185:
1184:
1177:
1168:
1167:
1139:
1133:
1132:
1114:
1094:
1088:
1087:
1076:
1070:
1069:
1058:
1052:
1042:
1031:
1021:
959:
958:
930:
923:
906:
890:
881:
849:
845:RefSeq (protein)
835:
819:
810:
778:
754:
735:
709:
690:
664:
645:
614:
509:
488:
473:
413:
411:Top expressed in
406:
383:Brodmann area 23
363:Brodmann area 46
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1683:
1682:
1678:
1677:
1676:
1674:
1673:
1672:
1658:
1657:
1656:
1621:
1586:
1556:(14): 3163–70.
1542:
1507:
1479:Genome Research
1472:
1435:
1400:
1357:
1336:
1301:
1256:
1227:
1198:
1194:
1192:Further reading
1189:
1188:
1179:
1178:
1171:
1141:
1140:
1136:
1112:10.1.1.575.4908
1096:
1095:
1091:
1078:
1077:
1073:
1060:
1059:
1055:
1043:
1034:
1022:
1013:
1008:
999:
968:View/Edit Mouse
963:View/Edit Human
926:
919:
916:Location (UCSC)
902:
898:
877:
871:
867:
863:
859:
855:
831:
827:
806:
800:
796:
792:
788:
784:
699:ENSG00000074211
592:
561:
540:
526:protein binding
469:
460:
455:
451:
449:cingulate gyrus
447:
443:
441:piriform cortex
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1681:
1679:
1671:
1670:
1660:
1659:
1655:
1654:
1619:
1584:
1540:
1505:
1470:
1433:
1398:
1355:
1334:
1299:
1254:
1225:
1207:(8): 1225–35.
1195:
1193:
1190:
1187:
1186:
1169:
1134:
1089:
1071:
1053:
1032:
1010:
1009:
1007:
1004:
998:
995:
975:
974:
971:
970:
965:
955:
954:
948:
947:
944:
943:
941:
939:
932:
931:
924:
917:
913:
912:
909:
908:
894:
893:
887:
884:
883:
873:
872:
846:
842:
841:
838:
837:
823:
822:
816:
813:
812:
802:
801:
775:
771:
770:
767:
766:
758:
757:
751:
748:
747:
739:
738:
732:
726:
725:
722:
721:
713:
712:
706:
703:
702:
694:
693:
687:
681:
680:
677:
676:
668:
667:
661:
658:
657:
649:
648:
642:
636:
635:
630:
625:
621:
620:
610:
609:
606:
605:
594:
593:
591:
590:
585:
580:
575:
569:
567:
563:
562:
560:
559:
554:
548:
546:
542:
541:
539:
538:
533:
528:
522:
520:
516:
515:
505:
504:
501:
500:
497:
496:
493:
492:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
379:occipital lobe
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1680:
1669:
1666:
1665:
1663:
1651:
1647:
1642:
1637:
1634:(2): 127–36.
1633:
1629:
1625:
1620:
1616:
1612:
1607:
1602:
1598:
1594:
1590:
1585:
1581:
1577:
1572:
1567:
1563:
1559:
1555:
1551:
1547:
1541:
1537:
1533:
1528:
1523:
1520:(2): 359–70.
1519:
1515:
1511:
1506:
1502:
1498:
1493:
1488:
1484:
1480:
1476:
1471:
1467:
1463:
1459:
1455:
1451:
1447:
1444:(4): 515–27.
1443:
1439:
1434:
1430:
1426:
1421:
1416:
1413:(2): 432–43.
1412:
1408:
1404:
1399:
1395:
1391:
1387:
1383:
1378:
1373:
1369:
1365:
1361:
1356:
1352:
1348:
1345:(4): 270–86.
1344:
1340:
1335:
1331:
1327:
1322:
1317:
1313:
1309:
1308:Cell Research
1305:
1300:
1296:
1292:
1287:
1282:
1277:
1272:
1268:
1264:
1263:Retrovirology
1260:
1255:
1251:
1247:
1243:
1239:
1235:
1231:
1226:
1222:
1218:
1214:
1210:
1206:
1202:
1197:
1196:
1191:
1182:
1176:
1174:
1170:
1165:
1161:
1157:
1153:
1149:
1145:
1138:
1135:
1130:
1126:
1122:
1118:
1113:
1108:
1104:
1100:
1093:
1090:
1085:
1081:
1075:
1072:
1067:
1063:
1057:
1054:
1050:
1046:
1041:
1039:
1037:
1033:
1029:
1025:
1020:
1018:
1016:
1012:
1005:
1003:
996:
994:
992:
989:
985:
981:
969:
964:
960:
956:
953:
949:
942:
940:
937:
933:
929:
925:
922:
918:
914:
907:
905:
901:
895:
891:
888:
882:
880:
874:
870:
866:
862:
858:
854:
850:
847:
843:
836:
834:
830:
824:
820:
817:
811:
809:
803:
799:
795:
791:
787:
783:
779:
776:
774:RefSeq (mRNA)
772:
765:
764:
759:
755:
752:
746:
745:
740:
736:
733:
731:
727:
720:
719:
714:
710:
707:
701:
700:
695:
691:
688:
686:
682:
675:
674:
669:
665:
662:
656:
655:
650:
646:
643:
641:
637:
634:
631:
629:
626:
622:
619:
615:
611:
604:
600:
595:
589:
586:
584:
581:
579:
576:
574:
571:
570:
568:
565:
564:
558:
555:
553:
550:
549:
547:
544:
543:
537:
534:
532:
529:
527:
524:
523:
521:
518:
517:
514:
513:Gene ontology
510:
506:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
421:visual cortex
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
371:parietal lobe
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1631:
1627:
1596:
1592:
1553:
1549:
1517:
1513:
1482:
1478:
1441:
1437:
1410:
1406:
1367:
1364:FEBS Letters
1363:
1342:
1338:
1314:(3): 143–9.
1311:
1307:
1266:
1262:
1236:(1): 43–51.
1233:
1229:
1204:
1200:
1147:
1143:
1137:
1105:(5): 323–7.
1102:
1099:DNA Research
1098:
1092:
1083:
1074:
1065:
1056:
1000:
987:
979:
978:
904:NP_001346932
897:
879:NP_001350317
876:
861:NP_001193925
857:NP_001193924
853:NP_001193923
833:NM_001360003
826:
808:NM_001363388
805:
790:NM_001206996
786:NM_001206995
782:NM_001206994
761:
742:
716:
697:
671:
652:
632:
627:
333:
326:
53:External IDs
1628:Cancer Cell
1150:(1): 83–6.
292:37,112,422
279:37,025,857
271:5|5 B3
31:Identifiers
1051:, May 2017
1030:, May 2017
1006:References
337:(ortholog)
191:6,563,600
178:6,320,578
74:HomoloGene
1107:CiteSeerX
900:NP_766582
869:NP_870991
865:NP_065149
829:NM_172994
798:NM_181876
794:NM_020416
618:Orthologs
82:GeneCards
1662:Category
1650:14998489
1615:12912990
1580:12136098
1536:11531413
1514:Virology
1466:20496320
1407:Virology
1394:23293768
1351:15817944
1330:15780175
1295:15725353
1250:15638722
1221:11007961
1164:10945473
1144:Genomics
1129:10574460
1047:–
1026:–
997:Function
952:Wikidata
597:Sources:
1501:9847074
1458:9514514
1429:9400615
1386:9013886
1049:Ensembl
1028:Ensembl
988:PPP2R2C
730:UniProt
685:Ensembl
624:Species
603:QuickGO
557:cytosol
312:pattern
86:PPP2R2C
70:2442660
45:PPP2R2C
38:Aliases
22:PPP2R2C
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984:enzyme
982:is an
938:search
936:PubMed
763:Q8BG02
744:Q9Y2T4
673:269643
640:Entrez
483:BioGPS
170:4p16.1
62:605997
1462:S2CID
1390:S2CID
633:Mouse
628:Human
599:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:36386
1646:PMID
1611:PMID
1576:PMID
1532:PMID
1497:PMID
1454:PMID
1425:PMID
1382:PMID
1347:PMID
1326:PMID
1291:PMID
1246:PMID
1217:PMID
1160:PMID
1125:PMID
991:gene
654:5522
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
1636:doi
1601:doi
1597:278
1566:PMC
1558:doi
1522:doi
1518:287
1487:doi
1446:doi
1442:392
1415:doi
1411:238
1372:doi
1368:401
1343:121
1316:doi
1281:PMC
1271:doi
1238:doi
1209:doi
1152:doi
1117:doi
491:n/a
288:End
187:End
90:OMA
66:MGI
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