336:
313:
210:
235:
2123:
587:
342:
241:
47:
2909:
2929:
1137:
Its malfunction acts in an autosomal dominant manner to cause pancreatitis. Many mutations that can lead to pancreatitis have been found. An example is a mutation at Arg 117. Arg 117 is a trypsin-sensitive site which can be cleaved by another trypsin and becomes inactivated. This site may be a
73:
1425:
Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, Martin SP, Gates LK, Amann ST, Toskes PP, Liddle R, McGrath K, Uomo G, Post JC, Ehrlich GD (1996). "Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene".
1138:
fail-safe mechanism by which trypsin, when activated within the pancreas, may become inactivated. Mutation at this cleavage site would result in a loss of control and permit autodigestion, causing pancreatitis.
1474:
Chen JM, Ferec C (2000). "Gene conversion-like missense mutations in the human cationic trypsinogen gene and insights into the molecular evolution of the human trypsinogen family".
2563:
2423:
2122:
349:
248:
1503:
Chen JM, Montier T, FĂ©rec C (2001). "Molecular pathology and evolutionary and physiological implications of pancreatitis-associated cationic trypsinogen mutations".
2163:
1608:"Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B."
1778:
Honey NK, Sakaguchi AY, Quinto C, et al. (1984). "Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase".
1749:
Emi M, Nakamura Y, Ogawa M, et al. (1986). "Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens".
2067:
800:
171:
781:
1113:. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the
3003:
1227:
2974:
2102:
1817:"Limited tryptic digestion near the amino terminus of bovine liver rhodanese produces active electrophoretic variants with altered refolding"
1209:
2993:
2156:
1004:
335:
1895:
Gaboriaud C, Serre L, Guy-Crotte O, et al. (1996). "Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151".
2628:
1011:
31:
1312:
1295:
312:
1961:"Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional properties"
1245:
1196:
1175:
2149:
2784:
2002:
Dahlen JR, Foster DC, Kisiel W (1998). "Expression, purification, and inhibitory properties of human proteinase inhibitor".
1192:
234:
209:
70:
1171:
2899:
2383:
151:
2141:
348:
247:
1850:
Rowen L, Koop BF, Hood L (1996). "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus".
2769:
1720:
Kimland M, Russick C, Marks WH, Borgström A (1990). "Immunoreactive anionic and cationic trypsin in human serum".
1642:"CD4-binding regions of human immunodeficiency virus envelope glycoprotein gp120 defined by proteolytic digestion"
341:
240:
2967:
2885:
2872:
2859:
2846:
2833:
2820:
2807:
2298:
2283:
2183:
2095:
1129:. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.
2779:
2733:
2676:
2180:
849:
159:
2681:
2573:
2538:
2533:
1540:
Howes N, Greenhalf W, Stocken DD, Neoptolemos JP (2005). "Cationic trypsinogen mutations and pancreatitis".
830:
826:
1386:"Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis"
2702:
2621:
2528:
2378:
2774:
2960:
2518:
2088:
1859:
223:
138:
2738:
2418:
2408:
2225:
2220:
987:
940:
2998:
2671:
1883:
1803:
1594:
1528:
1451:
1325:
183:
966:
919:
2400:
2044:
2019:
1990:
1947:
1912:
1875:
1838:
1795:
1766:
1737:
1708:
1673:
1628:
1586:
1557:
1520:
1491:
1443:
1407:
1366:
1317:
1276:
131:
63:
2944:
2717:
2712:
2686:
2614:
2192:
2011:
1980:
1972:
1937:
1904:
1867:
1828:
1787:
1758:
1729:
1698:
1663:
1653:
1618:
1578:
1549:
1512:
1483:
1435:
1397:
1356:
1307:
1268:
428:
359:
303:
258:
586:
179:
2764:
2748:
2661:
2433:
2428:
2200:
2176:
1110:
403:
1863:
2913:
2802:
2743:
1985:
1960:
1114:
46:
1833:
1816:
1703:
1686:
1623:
1607:
715:
710:
705:
700:
684:
679:
674:
669:
664:
648:
643:
638:
633:
628:
2987:
2707:
2666:
2578:
2451:
2440:
2172:
2071:
2053:
1762:
1733:
1668:
1641:
1402:
1385:
615:
1887:
1807:
1598:
1569:
Kandula L, Whitcomb DC, Lowe ME (2006). "Genetic issues in pediatric pancreatitis".
1532:
1455:
1329:
1259:
Rebours V, LĂ©vy P, Ruszniewski P (2011). "An overview of hereditary pancreatitiss".
163:
2940:
2656:
2474:
2368:
2210:
1126:
421:
200:
2131:: CRYSTAL STRUCTURE OF HUMAN TRYPSIN 1: UNEXPECTED PHOSPHORYLATION OF TYROSINE 151
1871:
187:
2880:
2815:
2651:
2593:
2588:
2237:
1232:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1214:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1086:
2908:
2038:
504:
2555:
2497:
2278:
2273:
2253:
1582:
1553:
1272:
320:
217:
167:
1942:
1925:
1658:
2854:
2828:
2583:
2569:
2388:
2268:
2258:
1361:
1344:
1172:
ENSG00000204983 GRCh38: Ensembl release 89: ENSG00000274247, ENSG00000204983
745:
564:
442:
387:
374:
286:
273:
175:
1908:
1590:
1561:
1524:
1495:
1487:
1370:
1280:
142:, TRP1, TRY1, TRY4, TRYP1, Trypsin 1, protease, serine 1, serine protease 1
2023:
1994:
1951:
1916:
1879:
1842:
1799:
1770:
1741:
1712:
1677:
1632:
1516:
1447:
1411:
1321:
1051:
1046:
2469:
2464:
2413:
2263:
2248:
2215:
1122:
1035:
894:
875:
2523:
2513:
2459:
2373:
2205:
2058:
2048:
1791:
1439:
1147:
1106:
1082:
1071:
861:
812:
2039:
GeneReviews/NCBI/NIH/UW entry on PRSS1-Related
Hereditary Pancreatitis
2015:
1976:
1313:
10.1002/(SICI)1098-1004(1998)12:1<39::AID-HUMU6>3.0.CO;2-P
108:
104:
100:
96:
92:
2867:
2637:
2550:
2492:
1118:
1019:
767:
17:
2928:
2841:
2559:
2545:
2484:
2358:
2353:
2348:
2343:
2338:
2333:
1296:"Mutations of the cationic trypsinogen in hereditary pancreatitis"
1094:
1090:
730:
726:
2936:
2328:
2323:
2318:
2313:
2308:
2303:
2293:
2288:
1078:
155:
2610:
2145:
2084:
1959:
Christensen S, Valnickova Z, Thogersen IB, et al. (1997).
595:
2080:
2043:
Overview of all the structural information available in the
1926:"The properties of the protein tyrosine phosphatase PTPMEG"
30:"PRSS1" redirects here. For the outer space satellite, see
2606:
1105:
This gene encodes a trypsinogen, which is a member of the
1125:. Mutations in this gene are associated with hereditary
411:
2948:
1384:
Gorry MC, Gabbaizedeh D, Furey W, et al. (1997).
2897:
1606:
Yamamoto KK, Pousette A, Chow P, et al. (1992).
576:
1246:"Entrez Gene: PRSS1 protease, serine, 1 (trypsin 1)"
2793:
2757:
2726:
2695:
2644:
2506:
2483:
2449:
2399:
2236:
2191:
980:
959:
933:
912:
1188:
1186:
1184:
1167:
1165:
1163:
1640:Pollard SR, Meier W, Chow P, et al. (1992).
358:
257:
1687:"The reactive site of human alpha 2-antiplasmin"
27:Protein-coding gene in the species Homo sapiens
1193:GRCm38: Ensembl release 89: ENSMUSG00000071521
2968:
2622:
2157:
2096:
8:
1345:"Molecular basis of hereditary pancreatitis"
2975:
2961:
2629:
2615:
2607:
2164:
2150:
2142:
2103:
2089:
2081:
2068:United States National Library of Medicine
1815:Merrill GA, Butler M, Horowitz PM (1993).
741:
611:
399:
298:
195:
81:
1984:
1941:
1832:
1702:
1667:
1657:
1622:
1401:
1360:
1311:
2066:This article incorporates text from the
685:collagen-containing extracellular matrix
2904:
2118:
1159:
2177:serine proteases/serine endopeptidases
36:
1089:secreted by pancreas, the others are
363:
324:
319:
262:
221:
216:
7:
2925:
2923:
1294:Teich N, Mössner J, Keim V (1998).
2947:. You can help Knowledge (XXG) by
977:
956:
930:
909:
885:
866:
840:
817:
791:
772:
634:serine-type endopeptidase activity
581:
499:
437:
416:
25:
1074:that in humans is encoded by the
32:Pakistan Remote Sensing Satellite
2927:
2907:
2121:
1571:Current Gastroenterology Reports
1403:10.1053/gast.1997.v113.pm9322498
711:extracellular matrix disassembly
585:
347:
340:
334:
311:
246:
239:
233:
208:
45:
649:serine-type peptidase activity
596:More reference expression data
565:More reference expression data
1:
3004:Human chromosome 7 gene stubs
2389:Urinary plasminogen activator
1872:10.1126/science.272.5269.1755
1834:10.1016/S0021-9258(18)82300-6
1704:10.1016/S0021-9258(18)45536-6
1624:10.1016/S0021-9258(18)45919-4
332:
231:
2384:Tissue plasminogen activator
1763:10.1016/0378-1119(86)90111-3
1734:10.1016/0009-8981(89)90254-4
1646:Proc. Natl. Acad. Sci. U.S.A
2994:Genes on human chromosome 7
1685:Shieh BH, Travis J (1987).
1261:Digestive and Liver Disease
1093:(anionic trypsinogen), and
706:cobalamin metabolic process
3020:
2922:
29:
2785:Michaelis–Menten kinetics
2475:Proteinase 3/Myeloblastin
2116:
2057:(Human Trypsin-1) at the
1924:Gu M, Majerus PW (1996).
1583:10.1007/s11894-006-0083-8
1554:10.1016/j.cll.2004.12.004
1343:Chen JM, Ferec C (2000).
1273:10.1016/j.dld.2011.08.003
1228:"Mouse PubMed Reference:"
1210:"Human PubMed Reference:"
1081:. Trypsin-1 is the main
1050:
1045:
1041:
1034:
1018:
1005:Chr 7: 142.75 – 142.75 Mb
999:
984:
963:
952:
937:
916:
905:
892:
888:
873:
869:
860:
847:
843:
824:
820:
811:
798:
794:
779:
775:
766:
751:
744:
740:
724:
614:
610:
593:
584:
575:
562:
547:quadriceps femoris muscle
511:
502:
449:
440:
410:
402:
398:
381:
368:
331:
310:
301:
297:
280:
267:
230:
207:
198:
194:
149:
146:
136:
129:
124:
89:
84:
67:
62:
57:
53:
44:
39:
2677:Diffusion-limited enzyme
1943:10.1074/jbc.271.44.27751
1659:10.1073/pnas.88.24.11320
1362:10.1038/sj.ejhg.5200492
1012:Chr 6: 41.33 – 41.33 Mb
2529:Proprotein convertases
1909:10.1006/jmbi.1996.0376
1780:Somat. Cell Mol. Genet
1488:10.1006/mgme.2000.3086
2770:Eadie–Hofstee diagram
2703:Allosteric regulation
2379:Plasminogen activator
1517:10.1007/s004390100580
1133:Clinical significance
675:extracellular exosome
477:right coronary artery
2780:Lineweaver–Burk plot
2519:Prolyl endopeptidase
1097:(meso-trypsinogen).
1068:cationic trypsinogen
665:extracellular region
326:Chromosome 6 (mouse)
224:Chromosome 7 (human)
85:List of PDB id codes
58:Available structures
1864:1996Sci...272.1755R
680:extracellular space
670:blood microparticle
519:islet of Langerhans
489:right lobe of liver
457:islet of Langerhans
2935:This article on a
2739:Enzyme superfamily
2672:Enzyme promiscuity
2070:, which is in the
1792:10.1007/BF01535632
1440:10.1038/ng1096-141
1349:Eur. J. Hum. Genet
850:ENSMUSG00000071521
694:Biological process
658:Cellular component
639:hydrolase activity
629:peptidase activity
622:Molecular function
2956:
2955:
2895:
2894:
2604:
2603:
2401:Complement system
2193:Digestive enzymes
2139:
2138:
2016:10.1021/bi970977p
1977:10.1042/bj3230847
1858:(5269): 1755–62.
1476:Mol. Genet. Metab
1061:
1060:
1057:
1056:
1030:
1029:
995:
994:
974:
973:
948:
947:
927:
926:
901:
900:
882:
881:
856:
855:
837:
836:
807:
806:
788:
787:
736:
735:
644:metal ion binding
606:
605:
602:
601:
571:
570:
558:
557:
496:
495:
485:left uterine tube
394:
393:
293:
292:
188:PRSS1 - orthologs
120:
119:
116:
115:
68:Ortholog search:
16:(Redirected from
3011:
2977:
2970:
2963:
2931:
2924:
2912:
2911:
2903:
2775:Hanes–Woolf plot
2718:Enzyme activator
2713:Enzyme inhibitor
2687:Enzyme catalysis
2631:
2624:
2617:
2608:
2166:
2159:
2152:
2143:
2125:
2105:
2098:
2091:
2082:
2027:
2010:(48): 14874–82.
1998:
1988:
1971:(Pt 3): 847–52.
1955:
1945:
1920:
1891:
1846:
1836:
1827:(21): 15611–20.
1811:
1774:
1745:
1722:Clin. Chim. Acta
1716:
1706:
1681:
1671:
1661:
1636:
1626:
1602:
1565:
1536:
1499:
1460:
1459:
1422:
1416:
1415:
1405:
1390:Gastroenterology
1381:
1375:
1374:
1364:
1340:
1334:
1333:
1315:
1291:
1285:
1284:
1256:
1250:
1249:
1242:
1236:
1235:
1224:
1218:
1217:
1206:
1200:
1190:
1179:
1169:
1111:serine proteases
1066:, also known as
1043:
1042:
1014:
1007:
990:
978:
969:
957:
953:RefSeq (protein)
943:
931:
922:
910:
886:
867:
841:
818:
792:
773:
742:
612:
598:
589:
582:
567:
507:
505:Top expressed in
500:
453:body of pancreas
445:
443:Top expressed in
438:
417:
400:
390:
377:
366:
351:
344:
338:
327:
315:
299:
289:
276:
265:
250:
243:
237:
226:
212:
196:
190:
141:
134:
111:
82:
76:
55:
54:
49:
37:
21:
3019:
3018:
3014:
3013:
3012:
3010:
3009:
3008:
2984:
2983:
2982:
2981:
2920:
2918:
2906:
2898:
2896:
2891:
2803:Oxidoreductases
2789:
2765:Enzyme kinetics
2753:
2749:List of enzymes
2722:
2691:
2662:Catalytic triad
2640:
2635:
2605:
2600:
2502:
2479:
2445:
2395:
2232:
2201:Enteropeptidase
2187:
2170:
2140:
2135:
2132:
2126:
2112:
2109:
2078:
2035:
2030:
2001:
1958:
1936:(44): 27751–9.
1923:
1903:(5): 995–1010.
1894:
1849:
1814:
1777:
1757:(2–3): 305–10.
1748:
1719:
1684:
1652:(24): 11320–4.
1639:
1605:
1568:
1539:
1502:
1473:
1469:
1467:Further reading
1464:
1463:
1428:Nature Genetics
1424:
1423:
1419:
1383:
1382:
1378:
1342:
1341:
1337:
1293:
1292:
1288:
1258:
1257:
1253:
1244:
1243:
1239:
1226:
1225:
1221:
1208:
1207:
1203:
1191:
1182:
1170:
1161:
1156:
1144:
1135:
1103:
1052:View/Edit Mouse
1047:View/Edit Human
1010:
1003:
1000:Location (UCSC)
986:
965:
939:
918:
831:ENSG00000204983
829:
827:ENSG00000274247
720:
689:
653:
594:
563:
554:
549:
545:
541:
537:
533:
529:
525:
521:
517:
503:
492:
487:
483:
479:
475:
471:
467:
465:body of stomach
463:
459:
455:
441:
385:
372:
364:
354:
353:
352:
345:
325:
302:Gene location (
284:
271:
263:
253:
252:
251:
244:
222:
199:Gene location (
150:
137:
130:
91:
69:
35:
28:
23:
22:
15:
12:
11:
5:
3017:
3015:
3007:
3006:
3001:
2996:
2986:
2985:
2980:
2979:
2972:
2965:
2957:
2954:
2953:
2932:
2917:
2916:
2893:
2892:
2890:
2889:
2876:
2863:
2850:
2837:
2824:
2811:
2797:
2795:
2791:
2790:
2788:
2787:
2782:
2777:
2772:
2767:
2761:
2759:
2755:
2754:
2752:
2751:
2746:
2741:
2736:
2730:
2728:
2727:Classification
2724:
2723:
2721:
2720:
2715:
2710:
2705:
2699:
2697:
2693:
2692:
2690:
2689:
2684:
2679:
2674:
2669:
2664:
2659:
2654:
2648:
2646:
2642:
2641:
2636:
2634:
2633:
2626:
2619:
2611:
2602:
2601:
2599:
2598:
2597:
2596:
2591:
2581:
2576:
2567:
2553:
2548:
2543:
2542:
2541:
2536:
2526:
2521:
2516:
2510:
2508:
2504:
2503:
2501:
2500:
2495:
2489:
2487:
2481:
2480:
2478:
2477:
2472:
2467:
2462:
2456:
2454:
2447:
2446:
2444:
2443:
2438:
2437:
2436:
2431:
2421:
2416:
2411:
2405:
2403:
2397:
2396:
2394:
2393:
2392:
2391:
2386:
2376:
2364:
2363:
2362:
2361:
2356:
2351:
2346:
2341:
2336:
2331:
2326:
2321:
2316:
2311:
2306:
2301:
2296:
2291:
2286:
2276:
2271:
2266:
2261:
2256:
2251:
2242:
2240:
2234:
2233:
2231:
2230:
2229:
2228:
2223:
2213:
2208:
2203:
2197:
2195:
2189:
2188:
2173:Endopeptidases
2171:
2169:
2168:
2161:
2154:
2146:
2137:
2136:
2134:
2133:
2127:
2120:
2117:
2114:
2113:
2110:
2108:
2107:
2100:
2093:
2085:
2063:
2062:
2041:
2034:
2033:External links
2031:
2029:
2028:
1999:
1956:
1921:
1892:
1847:
1812:
1775:
1746:
1717:
1697:(13): 6055–9.
1682:
1637:
1617:(4): 2575–81.
1603:
1566:
1542:Clin. Lab. Med
1537:
1500:
1470:
1468:
1465:
1462:
1461:
1417:
1376:
1335:
1286:
1251:
1237:
1219:
1201:
1180:
1158:
1157:
1155:
1152:
1151:
1150:
1143:
1140:
1134:
1131:
1115:carboxyl group
1102:
1099:
1059:
1058:
1055:
1054:
1049:
1039:
1038:
1032:
1031:
1028:
1027:
1025:
1023:
1016:
1015:
1008:
1001:
997:
996:
993:
992:
982:
981:
975:
972:
971:
961:
960:
954:
950:
949:
946:
945:
935:
934:
928:
925:
924:
914:
913:
907:
903:
902:
899:
898:
890:
889:
883:
880:
879:
871:
870:
864:
858:
857:
854:
853:
845:
844:
838:
835:
834:
822:
821:
815:
809:
808:
805:
804:
796:
795:
789:
786:
785:
777:
776:
770:
764:
763:
758:
753:
749:
748:
738:
737:
734:
733:
722:
721:
719:
718:
713:
708:
703:
697:
695:
691:
690:
688:
687:
682:
677:
672:
667:
661:
659:
655:
654:
652:
651:
646:
641:
636:
631:
625:
623:
619:
618:
608:
607:
604:
603:
600:
599:
591:
590:
579:
573:
572:
569:
568:
560:
559:
556:
555:
553:
552:
548:
544:
540:
536:
532:
528:
524:
520:
516:
512:
509:
508:
497:
494:
493:
491:
490:
486:
482:
478:
474:
470:
466:
462:
458:
454:
450:
447:
446:
434:
433:
425:
414:
408:
407:
404:RNA expression
396:
395:
392:
391:
383:
379:
378:
370:
367:
362:
356:
355:
346:
339:
333:
329:
328:
323:
317:
316:
308:
307:
295:
294:
291:
290:
282:
278:
277:
269:
266:
261:
255:
254:
245:
238:
232:
228:
227:
220:
214:
213:
205:
204:
192:
191:
148:
144:
143:
135:
127:
126:
122:
121:
118:
117:
114:
113:
87:
86:
78:
77:
66:
60:
59:
51:
50:
42:
41:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3016:
3005:
3002:
3000:
2997:
2995:
2992:
2991:
2989:
2978:
2973:
2971:
2966:
2964:
2959:
2958:
2952:
2950:
2946:
2942:
2938:
2933:
2930:
2926:
2921:
2915:
2910:
2905:
2901:
2887:
2883:
2882:
2877:
2874:
2870:
2869:
2864:
2861:
2857:
2856:
2851:
2848:
2844:
2843:
2838:
2835:
2831:
2830:
2825:
2822:
2818:
2817:
2812:
2809:
2805:
2804:
2799:
2798:
2796:
2792:
2786:
2783:
2781:
2778:
2776:
2773:
2771:
2768:
2766:
2763:
2762:
2760:
2756:
2750:
2747:
2745:
2744:Enzyme family
2742:
2740:
2737:
2735:
2732:
2731:
2729:
2725:
2719:
2716:
2714:
2711:
2709:
2708:Cooperativity
2706:
2704:
2701:
2700:
2698:
2694:
2688:
2685:
2683:
2680:
2678:
2675:
2673:
2670:
2668:
2667:Oxyanion hole
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2649:
2647:
2643:
2639:
2632:
2627:
2625:
2620:
2618:
2613:
2612:
2609:
2595:
2592:
2590:
2587:
2586:
2585:
2582:
2580:
2579:Streptokinase
2577:
2575:
2571:
2568:
2565:
2561:
2557:
2554:
2552:
2549:
2547:
2544:
2540:
2537:
2535:
2532:
2531:
2530:
2527:
2525:
2522:
2520:
2517:
2515:
2512:
2511:
2509:
2505:
2499:
2496:
2494:
2491:
2490:
2488:
2486:
2482:
2476:
2473:
2471:
2468:
2466:
2463:
2461:
2458:
2457:
2455:
2453:
2452:immune system
2448:
2442:
2441:C3-convertase
2439:
2435:
2432:
2430:
2427:
2426:
2425:
2422:
2420:
2417:
2415:
2412:
2410:
2407:
2406:
2404:
2402:
2398:
2390:
2387:
2385:
2382:
2381:
2380:
2377:
2375:
2372:
2370:
2366:
2365:
2360:
2357:
2355:
2352:
2350:
2347:
2345:
2342:
2340:
2337:
2335:
2332:
2330:
2327:
2325:
2322:
2320:
2317:
2315:
2312:
2310:
2307:
2305:
2302:
2300:
2297:
2295:
2292:
2290:
2287:
2285:
2282:
2281:
2280:
2277:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2247:
2244:
2243:
2241:
2239:
2235:
2227:
2224:
2222:
2219:
2218:
2217:
2214:
2212:
2209:
2207:
2204:
2202:
2199:
2198:
2196:
2194:
2190:
2185:
2182:
2178:
2174:
2167:
2162:
2160:
2155:
2153:
2148:
2147:
2144:
2130:
2124:
2119:
2115:
2106:
2101:
2099:
2094:
2092:
2087:
2086:
2083:
2079:
2076:
2075:
2073:
2072:public domain
2069:
2060:
2056:
2055:
2050:
2046:
2042:
2040:
2037:
2036:
2032:
2025:
2021:
2017:
2013:
2009:
2005:
2000:
1996:
1992:
1987:
1982:
1978:
1974:
1970:
1966:
1962:
1957:
1953:
1949:
1944:
1939:
1935:
1931:
1930:J. Biol. Chem
1927:
1922:
1918:
1914:
1910:
1906:
1902:
1898:
1893:
1889:
1885:
1881:
1877:
1873:
1869:
1865:
1861:
1857:
1853:
1848:
1844:
1840:
1835:
1830:
1826:
1822:
1821:J. Biol. Chem
1818:
1813:
1809:
1805:
1801:
1797:
1793:
1789:
1786:(4): 369–76.
1785:
1781:
1776:
1772:
1768:
1764:
1760:
1756:
1752:
1747:
1743:
1739:
1735:
1731:
1727:
1723:
1718:
1714:
1710:
1705:
1700:
1696:
1692:
1691:J. Biol. Chem
1688:
1683:
1679:
1675:
1670:
1665:
1660:
1655:
1651:
1647:
1643:
1638:
1634:
1630:
1625:
1620:
1616:
1612:
1611:J. Biol. Chem
1609:
1604:
1600:
1596:
1592:
1588:
1584:
1580:
1577:(3): 248–53.
1576:
1572:
1567:
1563:
1559:
1555:
1551:
1547:
1543:
1538:
1534:
1530:
1526:
1522:
1518:
1514:
1511:(3): 245–52.
1510:
1506:
1501:
1497:
1493:
1489:
1485:
1481:
1477:
1472:
1471:
1466:
1457:
1453:
1449:
1445:
1441:
1437:
1433:
1429:
1421:
1418:
1413:
1409:
1404:
1399:
1396:(4): 1063–8.
1395:
1391:
1387:
1380:
1377:
1372:
1368:
1363:
1358:
1354:
1350:
1346:
1339:
1336:
1331:
1327:
1323:
1319:
1314:
1309:
1305:
1301:
1297:
1290:
1287:
1282:
1278:
1274:
1270:
1266:
1262:
1255:
1252:
1247:
1241:
1238:
1233:
1229:
1223:
1220:
1215:
1211:
1205:
1202:
1198:
1194:
1189:
1187:
1185:
1181:
1177:
1173:
1168:
1166:
1164:
1160:
1153:
1149:
1146:
1145:
1141:
1139:
1132:
1130:
1128:
1124:
1120:
1116:
1112:
1108:
1100:
1098:
1096:
1092:
1088:
1084:
1080:
1077:
1073:
1069:
1065:
1053:
1048:
1044:
1040:
1037:
1033:
1026:
1024:
1021:
1017:
1013:
1009:
1006:
1002:
998:
991:
989:
983:
979:
976:
970:
968:
962:
958:
955:
951:
944:
942:
936:
932:
929:
923:
921:
915:
911:
908:
906:RefSeq (mRNA)
904:
897:
896:
891:
887:
884:
878:
877:
872:
868:
865:
863:
859:
852:
851:
846:
842:
839:
833:
832:
828:
823:
819:
816:
814:
810:
803:
802:
797:
793:
790:
784:
783:
778:
774:
771:
769:
765:
762:
759:
757:
754:
750:
747:
743:
739:
732:
728:
723:
717:
714:
712:
709:
707:
704:
702:
699:
698:
696:
693:
692:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
662:
660:
657:
656:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
626:
624:
621:
620:
617:
616:Gene ontology
613:
609:
597:
592:
588:
583:
580:
578:
574:
566:
561:
550:
546:
542:
538:
534:
530:
526:
522:
518:
514:
513:
510:
506:
501:
498:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
451:
448:
444:
439:
436:
435:
432:
430:
426:
424:
423:
419:
418:
415:
413:
409:
405:
401:
397:
389:
384:
380:
376:
371:
361:
357:
350:
343:
337:
330:
322:
318:
314:
309:
305:
300:
296:
288:
283:
279:
275:
270:
260:
256:
249:
242:
236:
229:
225:
219:
215:
211:
206:
202:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
145:
140:
133:
128:
123:
112:
110:
106:
102:
98:
94:
88:
83:
80:
79:
75:
72:
65:
61:
56:
52:
48:
43:
38:
33:
19:
2949:expanding it
2941:chromosome 7
2934:
2919:
2881:Translocases
2878:
2865:
2852:
2839:
2826:
2816:Transferases
2813:
2800:
2657:Binding site
2369:fibrinolysis
2367:
2245:
2211:Chymotrypsin
2128:
2077:
2065:
2064:
2052:
2007:
2004:Biochemistry
2003:
1968:
1964:
1933:
1929:
1900:
1897:J. Mol. Biol
1896:
1855:
1851:
1824:
1820:
1783:
1779:
1754:
1750:
1728:(1): 31–46.
1725:
1721:
1694:
1690:
1649:
1645:
1614:
1610:
1574:
1570:
1548:(1): 39–59.
1545:
1541:
1508:
1504:
1482:(3): 463–9.
1479:
1475:
1434:(2): 141–5.
1431:
1427:
1420:
1393:
1389:
1379:
1355:(7): 473–9.
1352:
1348:
1338:
1306:(1): 39–43.
1303:
1299:
1289:
1264:
1260:
1254:
1240:
1231:
1222:
1213:
1204:
1136:
1127:pancreatitis
1104:
1075:
1067:
1063:
1062:
988:NP_001034085
985:
964:
941:NM_001038996
938:
917:
893:
874:
848:
825:
799:
780:
760:
755:
427:
420:
285:142,753,076
272:142,749,468
147:External IDs
90:
2652:Active site
2274:Factor XIIa
2254:Factor VIIa
2238:Coagulation
2111:PDB gallery
1267:(1): 8–15.
1087:trypsinogen
716:proteolysis
527:granulocyte
386:41,334,848
373:41,331,039
365:6|6 B1
125:Identifiers
2988:Categories
2855:Isomerases
2829:Hydrolases
2696:Regulation
2556:Subtilisin
2498:Batroxobin
2279:Kallikrein
2269:Factor XIa
2259:Factor IXa
2226:Pancreatic
2221:Neutrophil
1965:Biochem. J
1505:Hum. Genet
1300:Hum. Mutat
1199:, May 2017
1178:, May 2017
1154:References
1109:family of
473:ectocervix
431:(ortholog)
168:HomoloGene
2999:EC 3.4.21
2939:on human
2734:EC number
2584:Cathepsin
2570:Sedolisin
2546:Prostasin
2264:Factor Xa
1095:trypsin-3
1091:trypsin-2
1064:Trypsin-1
967:NP_002760
920:NM_002769
746:Orthologs
701:digestion
539:esophagus
176:GeneCards
2758:Kinetics
2682:Cofactor
2645:Activity
2485:Venombin
2470:Tryptase
2465:Granzyme
2419:Factor I
2414:Factor D
2409:Factor B
2249:Thrombin
2246:factors:
2216:Elastase
1888:84766616
1808:40599814
1599:23606613
1591:16764792
1562:15749231
1533:24099557
1525:11702203
1496:11073713
1456:21974705
1371:10909845
1330:45885044
1281:21907651
1195:–
1174:–
1142:See also
1123:arginine
1101:Function
1036:Wikidata
725:Sources:
535:duodenum
515:pancreas
481:testicle
461:duodenum
2914:Biology
2868:Ligases
2638:Enzymes
2524:Pronase
2514:Acrosin
2460:Chymase
2374:Plasmin
2206:Trypsin
2059:PDBe-KB
2049:UniProt
2024:9402754
1995:9169621
1986:1218391
1952:8910369
1917:8683601
1880:8650574
1860:Bibcode
1852:Science
1843:8340386
1800:6589790
1771:3011602
1742:2598466
1713:2437112
1678:1763044
1633:1370825
1448:8841182
1412:9322498
1322:9633818
1197:Ensembl
1176:Ensembl
1148:Trypsin
1107:trypsin
1083:isoform
1072:protein
1070:, is a
862:UniProt
813:Ensembl
752:Species
731:QuickGO
543:jejunum
523:stomach
406:pattern
164:3687012
132:Aliases
2900:Portal
2842:Lyases
2551:Reelin
2493:Ancrod
2450:Other
2184:3.4.21
2054:P07477
2022:
1993:
1983:
1950:
1915:
1886:
1878:
1841:
1806:
1798:
1769:
1740:
1711:
1676:
1666:
1631:
1597:
1589:
1560:
1531:
1523:
1494:
1454:
1446:
1410:
1369:
1328:
1320:
1279:
1119:lysine
1022:search
1020:PubMed
895:Q792Z1
876:P07477
801:436522
768:Entrez
577:BioGPS
469:fundus
172:134623
156:276000
2943:is a
2794:Types
2560:Furin
2507:Other
2434:MASP2
2429:MASP1
2359:KLK15
2354:KLK14
2349:KLK13
2344:KLK12
2339:KLK11
2334:KLK10
1884:S2CID
1804:S2CID
1669:53126
1595:S2CID
1529:S2CID
1452:S2CID
1326:S2CID
1076:PRSS1
761:Mouse
756:Human
727:Amigo
551:liver
531:colon
429:Mouse
422:Human
369:Start
304:Mouse
268:Start
201:Human
180:PRSS1
139:PRSS1
40:PRSS1
18:PRSS1
2945:stub
2937:gene
2886:list
2879:EC7
2873:list
2866:EC6
2860:list
2853:EC5
2847:list
2840:EC4
2834:list
2827:EC3
2821:list
2814:EC2
2808:list
2801:EC1
2574:TPP1
2424:MASP
2329:KLK9
2324:KLK8
2319:KLK7
2314:KLK6
2309:KLK5
2304:KLK4
2299:KLK3
2294:KLK2
2289:KLK1
2129:1trn
2047:for
2020:PMID
1991:PMID
1948:PMID
1913:PMID
1876:PMID
1839:PMID
1796:PMID
1767:PMID
1751:Gene
1738:PMID
1709:PMID
1674:PMID
1629:PMID
1587:PMID
1558:PMID
1521:PMID
1492:PMID
1444:PMID
1408:PMID
1367:PMID
1318:PMID
1277:PMID
1079:gene
782:5644
412:Bgee
360:Band
321:Chr.
264:7q34
259:Band
218:Chr.
152:OMIM
109:4WXV
105:4WWY
101:2RA3
97:1TRN
93:1FXY
74:RCSB
71:PDBe
2564:S1P
2284:PSA
2045:PDB
2012:doi
1981:PMC
1973:doi
1969:323
1938:doi
1934:271
1905:doi
1901:259
1868:doi
1856:272
1829:doi
1825:268
1788:doi
1759:doi
1730:doi
1726:184
1699:doi
1695:262
1664:PMC
1654:doi
1619:doi
1615:267
1579:doi
1550:doi
1513:doi
1509:109
1484:doi
1436:doi
1398:doi
1394:113
1357:doi
1308:doi
1269:doi
1121:or
1117:of
1085:of
382:End
281:End
184:OMA
160:MGI
64:PDB
2990::
2181:EC
2175::
2051::
2018:.
2008:36
2006:.
1989:.
1979:.
1967:.
1963:.
1946:.
1932:.
1928:.
1911:.
1899:.
1882:.
1874:.
1866:.
1854:.
1837:.
1823:.
1819:.
1802:.
1794:.
1784:10
1782:.
1765:.
1755:41
1753:.
1736:.
1724:.
1707:.
1693:.
1689:.
1672:.
1662:.
1650:88
1648:.
1644:.
1627:.
1613:.
1593:.
1585:.
1573:.
1556:.
1546:25
1544:.
1527:.
1519:.
1507:.
1490:.
1480:71
1478:.
1450:.
1442:.
1432:14
1430:.
1406:.
1392:.
1388:.
1365:.
1351:.
1347:.
1324:.
1316:.
1304:12
1302:.
1298:.
1275:.
1265:44
1263:.
1230:.
1212:.
1183:^
1162:^
729:/
388:bp
375:bp
287:bp
274:bp
182:;
178::
174:;
170::
166:;
162::
158:;
154::
107:,
103:,
99:,
95:,
2976:e
2969:t
2962:v
2951:.
2902::
2888:)
2884:(
2875:)
2871:(
2862:)
2858:(
2849:)
2845:(
2836:)
2832:(
2823:)
2819:(
2810:)
2806:(
2630:e
2623:t
2616:v
2594:G
2589:A
2572:/
2566:4
2562:/
2558:/
2539:2
2534:1
2371::
2186:)
2179:(
2165:e
2158:t
2151:v
2104:e
2097:t
2090:v
2074:.
2061:.
2026:.
2014::
1997:.
1975::
1954:.
1940::
1919:.
1907::
1890:.
1870::
1862::
1845:.
1831::
1810:.
1790::
1773:.
1761::
1744:.
1732::
1715:.
1701::
1680:.
1656::
1635:.
1621::
1601:.
1581::
1575:8
1564:.
1552::
1535:.
1515::
1498:.
1486::
1458:.
1438::
1414:.
1400::
1373:.
1359::
1353:8
1332:.
1310::
1283:.
1271::
1248:.
1234:.
1216:.
306:)
203:)
186::
34:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
