1308:
chamber. In an inactivated 20S proteasome complex, the gate into the internal proteolytic chamber are guarded by the N-terminal tails of specific alpha-subunit. The proteolytic capacity of 20S core particle (CP) can be activated when CP associates with one or two regulatory particles (RP) on one or both side of alpha rings. These regulatory particles include 19S proteasome complexes, 11S proteasome complex, etc. Following the CP-RP association, the confirmation of certain alpha subunits will change and consequently cause the opening of substrate entrance gate. Besides RPs, the 20S proteasomes can also be effectively activated by other mild chemical treatments, such as exposure to low levels of sodium dodecylsulfate (SDS) or NP-14.
326:
303:
200:
225:
3659:
577:
332:
231:
29:
1344:. Subsequently, a compromised proteasome complex assembly and function lead to reduced proteolytic activities and the accumulation of damaged or misfolded protein species. Such protein accumulation may contribute to the pathogenesis and phenotypic characteristics in neurodegenerative diseases, cardiovascular diseases, inflammatory responses and autoimmune diseases, and systemic DNA damage responses leading to
1298:
is a multicatalytic proteinase complex with a highly ordered 20S core structure. This barrel-shaped core structure is composed of 4 axially stacked rings of 28 non-identical subunits: the two end rings are each formed by 7 alpha subunits, and the two central rings are each formed by 7 beta subunits.
1555:
and compared to controls. The study reviled that PSMB4 mRNA was significantly associated with proliferative activity of neuroendocrine pulmonary tumors. However, a role of PSMA5 was also indicated in neuroendocrine pulmonary tumors. The PSMA5 protein has further been associated with the biosynthesis
1307:
Crystal structures of isolated 20S proteasome complex demonstrate that the two rings of beta subunits form a proteolytic chamber and maintain all their active sites of proteolysis within the chamber. Concomitantly, the rings of alpha subunits form the entrance for substrates entering the proteolytic
1299:
Three beta subunits (beta1, beta2, and beta5) each contains a proteolytic active site and has distinct substrate preferences. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.
1400:. Additionally, evidence is accumulating that the UPS plays an essential role in malignant transformation. UPS proteolysis plays a major role in responses of cancer cells to stimulatory signals that are critical for the development of cancer. Accordingly, gene expression by degradation of
1316:
The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic
1317:
interventions. More recently, more effort has been made to consider the proteasome for the development of novel diagnostic markers and strategies. An improved and comprehensive understanding of the pathophysiology of the proteasome should lead to clinical applications in the future.
1259:
The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of
3543:
Huang X, Seifert U, Salzmann U, Henklein P, Preissner R, Henke W, Sijts AJ, Kloetzel PM, Dubiel W (November 2002). "The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing".
55:
1281:
encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. The gene has 9 exons and locates at chromosome band 1p13. The human protein proteasome subunit alpha type-5 is 26.5 kDa in size and composed of 241 amino acids. The calculated theoretical pI
1670:
DeMartino GN, Orth K, McCullough ML, Lee LW, Munn TZ, Moomaw CR, Dawson PA, Slaughter CA (August 1991). "The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous".
2872:
Mairinger FD, Walter RF, Theegarten D, Hager T, Vollbrecht C, Christoph DC, Worm K, Ting S, Werner R, Stamatis G, Mairinger T, Baba H, Zarogoulidis K, Huang H, Li Q, Tsakiridis K, Zarogoulidis P, Schmid KW, Wohlschlaeger J (2014).
1251:. This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex.
1480:). The UPS is also involved in the regulation of inflammatory responses. This activity is usually attributed to the role of proteasomes in the activation of NF-ÎşB which further regulates the expression of pro inflammatory
3442:
Engidawork E, Juranville JF, Fountoulakis M, Dierssen M, Lubec G (2001). "Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome".
3066:
Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (December 1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes".
2844:
Egerer K, Kuckelkorn U, Rudolph PE, Rückert JC, Dörner T, Burmester GR, Kloetzel PM, Feist E (October 2002). "Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseases".
1351:
Several experimental and clinical studies have indicated that aberrations and deregulations of the UPS contribute to the pathogenesis of several neurodegenerative and myodegenerative disorders, including
2504:
Manaka H, Kato T, Kurita K, Katagiri T, Shikama Y, Kujirai K, Kawanami T, Suzuki Y, Nihei K, Sasaki H (May 1992). "Marked increase in cerebrospinal fluid ubiquitin in
Creutzfeldt-Jakob disease".
2875:"Gene Expression Analysis of the 26S Proteasome Subunit PSMB4 Reveals Significant Upregulation, Different Expression and Association with Proliferation in Human Pulmonary Neuroendocrine Tumours"
2461:
Ikeda K, Akiyama H, Arai T, Ueno H, Tsuchiya K, Kosaka K (July 2002). "Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia".
1432:
are all controlled by the UPS and thus involved in the development of various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as
3197:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
1516:(NO). Additionally, the UPS also plays a role in inflammatory responses as regulators of leukocyte proliferation, mainly through proteolysis of cyclines and the degradation of
339:
238:
3727:
3104:
Kristensen P, Johnsen AH, Uerkvitz W, Tanaka K, Hendil KB (December 1994). "Human proteasome subunits from 2-dimensional gels identified by partial sequencing".
3699:
3658:
2415:
Chung KK, Dawson VL, Dawson TM (November 2001). "The role of the ubiquitin-proteasomal pathway in
Parkinson's disease and other neurodegenerative disorders".
3498:
Sheehy AM, Gaddis NC, Choi JD, Malim MH (August 2002). "Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein".
1264:
peptides. As a component of alpha ring, Proteasome subunit alpha type-5 contributes to the formation of heptameric alpha rings and substrate entrance gate.
1875:
Groll M, Bajorek M, Köhler A, Moroder L, Rubin DM, Huber R, Glickman MH, Finley D (November 2000). "A gated channel into the proteasome core particle".
950:
931:
161:
3133:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
2924:"Conjugated linoleic acid synthesis-related protein proteasome subunit α 5 (PSMA5) is increased by vaccenic acid treatment in goat mammary tissue"
1821:
Groll M, Ditzel L, Löwe J, Stock D, Bochtler M, Bartunik HD, Huber R (April 1997). "Structure of 20S proteasome from yeast at 2.4 A resolution".
1445:
3638:
3460:
1652:
2922:
Jin YC, Li ZH, Hong ZS, Xu CX, Han JA, Choi SH, Yin JL, Zhang QK, Lee KB, Kang SK, Song MK, Kim YJ, Kang HS, Choi YJ, Lee HG (August 2012).
1634:
4013:
2377:
Checler F, da Costa CA, Ancolio K, Chevallier N, Lopez-Perez E, Marambaud P (July 2000). "Role of the proteasome in
Alzheimer's disease".
1174:
325:
1181:
3692:
302:
2049:
Sulistio YA, Heese K (March 2016). "The
Ubiquitin–Proteasome System and Molecular Chaperone Deregulation in Alzheimer's Disease".
3708:
1720:
1706:
1569:
1385:
1321:
1621:
1600:
3312:
Simon JH, Gaddis NC, Fouchier RA, Malim MH (December 1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype".
2293:
Karin M, Delhase M (February 2000). "The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling".
1617:
1373:
224:
199:
52:
3349:
Jørgensen L, Hendil KB (April 1999). "Proteasome subunit zeta, a putative ribonuclease, is also found as a free monomer".
1365:
1596:
3685:
3421:
Feng Y, Longo DL, Ferris DK (January 2001). "Polo-like kinase interacts with proteasomes and regulates their activity".
2963:
Feng Y, Longo DL, Ferris DK (January 2001). "Polo-like kinase interacts with proteasomes and regulates their activity".
1525:
141:
1552:
338:
237:
3271:"An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein"
1437:
1433:
3575:"Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions"
331:
230:
3631:
3712:
1918:
Zong C, Gomes AV, Drews O, Li X, Young GW, Berhane B, Qiao X, French SW, Bardag-Gorce F, Ping P (August 2006).
1557:
995:
149:
1517:
1393:
1369:
976:
3228:"Twelve genes, including the unassigned proteasome zeta subunit gene, ordered within the human 1p13 region"
2674:
Predmore JM, Wang P, Davis F, Bartolone S, Westfall MV, Dyke DB, Pagani F, Powell SR, Day SM (March 2010).
3677:
1357:
1353:
1388:(UPS), the proteasome maintains cardiac protein homeostasis and thus plays a significant role in cardiac
1401:
2194:"Targeting the ubiquitin-proteasome system in heart disease: the basis for new therapeutic strategies"
3624:
3507:
1830:
1533:
1377:
213:
128:
1529:
1132:
1128:
1124:
1077:
1073:
1069:
3531:
3478:
3374:
3337:
3257:
3092:
3054:
2826:
2748:
2572:
2529:
2486:
2440:
2074:
1900:
1854:
1521:
1493:
1429:
173:
2994:
Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes".
1734:
Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes".
1536:(RA) predominantly exhibit circulating proteasomes which can be applied as clinical biomarkers.
1157:
1136:
1098:
1065:
726:
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
3604:
3561:
3523:
3466:
3456:
3430:
3409:
3366:
3329:
3300:
3249:
3214:
3185:
3150:
3121:
3084:
3046:
3011:
2972:
2945:
2904:
2854:
2818:
2783:
2740:
2723:
Powell SR (July 2006). "The ubiquitin-proteasome system in cardiac physiology and pathology".
2705:
2656:
2607:
2564:
2521:
2478:
2432:
2394:
2359:
2310:
2272:
2223:
2174:
2125:
2066:
2031:
1990:
1941:
1892:
1846:
1803:
1751:
1688:
1361:
1283:
121:
45:
3594:
3586:
3553:
3515:
3448:
3399:
3358:
3321:
3290:
3282:
3239:
3206:
3175:
3142:
3113:
3076:
3036:
3003:
2935:
2894:
2886:
2810:
2801:
Ben-Neriah Y (January 2002). "Regulatory functions of ubiquitination in the immune system".
2775:
2732:
2695:
2687:
2646:
2638:
2599:
2590:
Mayer RJ (March 2003). "From neurodegeneration to neurohomeostasis: the role of ubiquitin".
2556:
2513:
2470:
2424:
2386:
2349:
2341:
2302:
2262:
2254:
2213:
2205:
2164:
2156:
2115:
2105:
2058:
2021:
1980:
1972:
1931:
1884:
1838:
1793:
1785:
1743:
1680:
418:
349:
293:
248:
576:
169:
3490:
1789:
1449:
393:
3511:
3007:
2766:
Adams J (April 2003). "Potential for proteasome inhibition in the treatment of cancer".
1834:
1747:
3286:
2899:
2874:
2700:
2675:
2651:
2626:
2354:
2329:
2267:
2242:
2218:
2193:
2169:
2144:
2120:
2093:
1985:
1960:
1936:
1919:
1798:
1773:
1509:
1441:
1325:
28:
3599:
3574:
3557:
3295:
3270:
3210:
3041:
3024:
2779:
2691:
2428:
2390:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
638:
633:
628:
623:
618:
4007:
3590:
3146:
2676:"Ubiquitin proteasome dysfunction in human hypertrophic and dilated cardiomyopathies"
2517:
2026:
2009:
1684:
1489:
1397:
605:
3378:
3341:
3261:
3096:
3058:
2830:
2533:
2490:
2078:
1904:
1332:
and degradation by the proteasome are important mechanisms in the regulation of the
153:
3535:
3164:"HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation"
2752:
2576:
2444:
1858:
1513:
1345:
411:
190:
836:
regulation of transcription from RNA polymerase II promoter in response to hypoxia
3452:
2603:
177:
2736:
2642:
2160:
2010:"New insights into proteasome function: from archaebacteria to drug development"
1673:
Biochimica et
Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
1657:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1639:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1337:
1329:
1261:
2258:
494:
3362:
2560:
2474:
2345:
2062:
1976:
1505:
1477:
1473:
1469:
1461:
1453:
1333:
1295:
310:
207:
157:
3080:
2110:
3180:
3163:
2243:"Protein quality control and metabolism: bidirectional control in the heart"
1920:"Regulation of murine cardiac 20S proteasomes: role of associating partners"
1481:
1341:
895:
554:
432:
377:
364:
276:
263:
165:
3608:
3565:
3527:
3470:
3434:
3413:
3404:
3387:
3370:
3117:
3050:
2976:
2949:
2908:
2858:
2822:
2787:
2744:
2709:
2660:
2611:
2568:
2482:
2436:
2398:
2363:
2314:
2306:
2276:
2227:
2178:
2129:
2070:
1994:
1945:
1896:
1807:
1721:"Entrez Gene: PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4"
1707:"Entrez Gene: PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5"
3333:
3304:
3253:
3244:
3227:
3218:
3189:
3154:
3125:
3088:
3015:
2940:
2923:
2525:
2330:"Quality control mechanisms in cellular and systemic DNA damage responses"
2209:
2035:
1850:
1755:
1692:
1221:
1216:
1485:
1465:
1417:
1389:
1381:
1324:(UPS) and corresponding cellular Protein Quality Control (PQC). Protein
1205:
1040:
1021:
3667:: Crystal Structure of the mammalian 20S proteasome at 2.75 A resolution
3519:
132:, PSC5, ZETA, proteasome subunit alpha 5, proteasome 20S subunit alpha 5
2547:
Mathews KD, Moore SA (January 2003). "Limb-girdle muscular dystrophy".
1241:
1007:
962:
816:
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
2814:
98:
94:
90:
86:
82:
78:
74:
3945:
3940:
3935:
3930:
3925:
3823:
3573:
Gaddis NC, Chertova E, Sheehy AM, Henderson LE, Malim MH (May 2003).
2890:
1842:
1501:
1497:
1380:
and several rare forms of neurodegenerative diseases associated with
1189:
917:
3992:
3976:
3971:
3966:
3961:
3920:
3915:
3910:
3905:
3900:
3895:
3890:
3885:
3880:
3864:
3859:
3854:
3849:
3844:
3839:
3818:
3813:
3808:
3803:
3798:
3793:
3788:
3783:
3778:
3762:
3757:
3752:
3742:
3737:
3732:
2145:"Proteotoxicity: an underappreciated pathology in cardiac disease"
1888:
1774:"Molecular architecture and assembly of the eukaryotic proteasome"
1548:
1544:
1540:
1425:
1421:
1413:
1409:
3325:
3025:"Death by deamination: a novel host restriction system for HIV-1"
2094:"Ubiquitin–proteasome system involvement in Huntington's disease"
1340:
and differentiation, gene transcription, signal transduction and
880:
876:
821:
proteasome-mediated ubiquitin-dependent protein catabolic process
2725:
American
Journal of Physiology. Heart and Circulatory Physiology
2631:
American
Journal of Physiology. Heart and Circulatory Physiology
2379:
Biochimica et
Biophysica Acta (BBA) - Molecular Basis of Disease
1573:
1248:
145:
3681:
3620:
585:
3616:
1457:
1405:
1961:"Perilous journey: a tour of the ubiquitin–proteasome system"
1376:, and motor neuron diseases, polyglutamine (PolyQ) diseases,
806:
negative regulation of G2/M transition of mitotic cell cycle
856:
proteasomal ubiquitin-independent protein catabolic process
3388:"Degradation of HIV-1 integrase by the N-end rule pathway"
2328:
Ermolaeva MA, Dakhovnik A, Schumacher B (September 2015).
786:
proteolysis involved in cellular protein catabolic process
2627:"The ubiquitin proteasome system and myocardial ischemia"
401:
3226:
Mayau V, Baron B, Buttin G, Debatisse M (April 1998).
796:
negative regulation of canonical Wnt signaling pathway
781:
anaphase-promoting complex-dependent catabolic process
741:
positive regulation of canonical Wnt signaling pathway
3162:
Seeger M, Ferrell K, Frank R, Dubiel W (March 1997).
846:
regulation of hematopoietic stem cell differentiation
566:
1539:
Gene expression levels of the proteasomal subunits (
751:
stimulatory C-type lectin receptor signaling pathway
3985:
3954:
3873:
3832:
3771:
3720:
3106:
Biochemical and Biophysical Research Communications
2456:
2454:
1150:
1117:
1091:
1058:
801:
Wnt signaling pathway, planar cell polarity pathway
721:
regulation of cellular amino acid metabolic process
1613:
1611:
1609:
1592:
1590:
1588:
1320:The proteasomes form a pivotal component for the
866:regulation of mitotic cell cycle phase transition
348:
247:
1428:, sterol-regulated element-binding proteins and
756:tumor necrosis factor-mediated signaling pathway
2288:
2286:
1618:GRCm38: Ensembl release 89: ENSMUSG00000068749
705:proteasome core complex, alpha-subunit complex
3693:
3632:
2410:
2408:
2008:Goldberg AL, Stein R, Adams J (August 1995).
1870:
1868:
731:ubiquitin-dependent protein catabolic process
8:
2149:Journal of Molecular and Cellular Cardiology
1767:
1765:
1597:GRCh38: Ensembl release 89: ENSG00000143106
3700:
3686:
3678:
3639:
3625:
3617:
2549:Current Neurology and Neuroscience Reports
891:
601:
389:
288:
185:
63:
3598:
3445:Protein Expression in Down Syndrome Brain
3403:
3294:
3243:
3179:
3040:
2939:
2898:
2699:
2650:
2353:
2266:
2217:
2168:
2119:
2109:
2025:
1984:
1935:
1797:
3386:Mulder LC, Muesing MA (September 2000).
1551:) were investigated in 80 patients with
861:interleukin-1-mediated signaling pathway
3654:
2192:Drews O, Taegtmeyer H (December 2014).
1584:
841:post-translational protein modification
3486:
3476:
18:
2625:Calise J, Powell SR (February 2013).
1790:10.1146/annurev-biochem-060410-150257
851:proteasomal protein catabolic process
771:Fc-epsilon receptor signaling pathway
634:threonine-type endopeptidase activity
353:
314:
309:
252:
211:
206:
7:
3392:The Journal of Biological Chemistry
3269:Madani N, Kabat D (December 1998).
3168:The Journal of Biological Chemistry
3008:10.1146/annurev.bi.65.070196.004101
2098:Frontiers in Molecular Neuroscience
1748:10.1146/annurev.bi.65.070196.004101
3287:10.1128/JVI.72.12.10251-10255.1998
2241:Wang ZV, Hill JA (February 2015).
2198:Antioxidants & Redox Signaling
1937:10.1161/01.RES.0000237389.40000.02
1446:von Hippel–Lindau tumor suppressor
1147:
1114:
1088:
1055:
1031:
1012:
986:
967:
941:
922:
571:
489:
427:
406:
14:
3423:Cell Growth & Differentiation
2965:Cell Growth & Differentiation
2692:10.1161/circulationaha.109.904557
2143:Sandri M, Robbins J (June 2014).
1772:Tomko RJ, Hochstrasser M (2013).
1244:that in humans is encoded by the
791:T cell receptor signaling pathway
3709:Proteasome endopeptidase complex
3657:
3591:10.1128/JVI.77.10.5810-5820.2003
1959:Kleiger G, Mayor T (June 2014).
575:
337:
330:
324:
301:
236:
229:
223:
198:
27:
1553:neuroendocrine pulmonary tumors
1234:Proteasome subunit alpha type-5
1448:(VHL), as well as a number of
1238:20S proteasome subunit alpha-5
586:More reference expression data
555:More reference expression data
1:
3558:10.1016/S0022-2836(02)00998-1
3211:10.1016/S0378-1119(97)00411-3
3042:10.1016/S0092-8674(03)00602-0
2996:Annual Review of Biochemistry
2780:10.1016/s1359-6446(03)02647-3
2429:10.1016/s0166-2236(00)01998-6
2391:10.1016/s0925-4439(00)00039-9
1778:Annual Review of Biochemistry
1736:Annual Review of Biochemistry
1366:Amyotrophic lateral sclerosis
322:
221:
3546:Journal of Molecular Biology
3453:10.1007/978-3-7091-6262-0_10
3147:10.1016/0378-1119(94)90802-8
2604:10.1358/dnp.2003.16.2.829327
2592:Drug News & Perspectives
2518:10.1016/0304-3940(92)90854-z
2027:10.1016/1074-5521(95)90182-5
1685:10.1016/0167-4838(91)90020-Z
736:regulation of mRNA stability
695:ficolin-1-rich granule lumen
4014:Genes on human chromosome 1
2847:The Journal of Rheumatology
2737:10.1152/ajpheart.00062.2006
2643:10.1152/ajpheart.00604.2012
2161:10.1016/j.yjmcc.2013.12.015
2092:Ortega Z, Lucas JJ (2014).
1386:ubiquitin–proteasome system
1322:ubiquitin–proteasome system
1286:) of this protein is 4.69.
459:stromal cell of endometrium
4030:
2259:10.1016/j.cmet.2015.01.016
1434:adenomatous polyposis coli
746:protein polyubiquitination
451:mucosa of transverse colon
3652:
3351:Molecular Biology Reports
2561:10.1007/s11910-003-0042-9
2475:10.1007/s00401-001-0513-5
2346:10.1016/j.arr.2014.12.009
2063:10.1007/s12035-014-9063-4
1977:10.1016/j.tcb.2013.12.003
1877:Nature Structural Biology
1653:"Mouse PubMed Reference:"
1635:"Human PubMed Reference:"
1560:(CLA) in mammary tissue.
1374:Creutzfeldt–Jakob disease
1220:
1215:
1211:
1204:
1188:
1182:Chr 3: 108.16 – 108.19 Mb
1169:
1154:
1121:
1110:
1095:
1062:
1051:
1038:
1034:
1019:
1015:
1006:
993:
989:
974:
970:
961:
948:
944:
929:
925:
916:
901:
894:
890:
874:
604:
600:
583:
574:
565:
552:
501:
492:
439:
430:
400:
392:
388:
371:
358:
321:
300:
291:
287:
270:
257:
220:
197:
188:
184:
139:
136:
126:
119:
114:
71:
66:
49:
44:
39:
35:
26:
21:
3081:10.1002/elps.11501301199
2928:Journal of Dairy Science
2111:10.3389/fnmol.2014.00077
1568:PSMA5 has been shown to
1558:conjugated linoleic acid
1440:) in colorectal cancer,
1175:Chr 1: 109.4 – 109.43 Mb
826:neutrophil degranulation
811:protein deubiquitination
3363:10.1023/A:1006965602142
3181:10.1074/jbc.272.13.8145
3023:Goff SP (August 2003).
2417:Trends in Neurosciences
2334:Ageing Research Reviews
2014:Chemistry & Biology
1394:ventricular hypertrophy
831:transmembrane transport
776:NIK/NF-kappaB signaling
690:secretory granule lumen
670:proteasome core complex
16:Protein found in humans
3955:E (activator subunits)
3405:10.1074/jbc.M004670200
3118:10.1006/bbrc.1994.2876
2307:10.1006/smim.2000.0210
2295:Seminars in Immunology
2051:Molecular Neurobiology
1965:Trends in Cell Biology
619:endopeptidase activity
3986:F (inhibitor subunit)
3245:10.1007/s003359900761
2941:10.3168/jds.2011-4281
2463:Acta Neuropathologica
2210:10.1089/ars.2013.5823
1402:transcription factors
1312:Clinical significance
660:extracellular exosome
2768:Drug Discovery Today
2506:Neuroscience Letters
1924:Circulation Research
1534:rheumatoid arthritis
1520:inhibitors. Lastly,
1378:Muscular dystrophies
1370:Huntington's disease
675:extracellular region
316:Chromosome 3 (mouse)
214:Chromosome 1 (human)
67:List of PDB id codes
40:Available structures
3579:Journal of Virology
3520:10.1038/nature00939
3512:2002Natur.418..646S
3447:. pp. 117–30.
3275:Journal of Virology
2423:(11 Suppl): S7–14.
1835:1997Natur.386..463G
1358:Parkinson's disease
1354:Alzheimer's disease
537:ganglionic eminence
479:right adrenal gland
463:epithelium of colon
3721:A (alpha subunits)
1522:autoimmune disease
1494:adhesion molecules
1430:androgen receptors
996:ENSMUSG00000068749
714:Biological process
655:proteasome complex
648:Cellular component
639:hydrolase activity
624:peptidase activity
612:Molecular function
4001:
4000:
3772:B (beta subunits)
3675:
3674:
3462:978-3-211-83704-7
2879:Journal of Cancer
2815:10.1038/ni0102-20
2803:Nature Immunology
1424:, HIF-1α, MATα2,
1384:. As part of the
1284:isoelectric point
1231:
1230:
1227:
1226:
1200:
1199:
1165:
1164:
1144:
1143:
1106:
1105:
1085:
1084:
1047:
1046:
1028:
1027:
1002:
1001:
983:
982:
957:
956:
938:
937:
886:
885:
596:
595:
592:
591:
561:
560:
548:
547:
486:
485:
384:
383:
283:
282:
178:PSMA5 - orthologs
110:
109:
106:
105:
50:Ortholog search:
4021:
3702:
3695:
3688:
3679:
3661:
3641:
3634:
3627:
3618:
3612:
3602:
3569:
3539:
3506:(6898): 646–50.
3494:
3488:
3484:
3482:
3474:
3438:
3417:
3407:
3398:(38): 29749–53.
3382:
3345:
3320:(12): 1397–400.
3308:
3298:
3265:
3247:
3232:Mammalian Genome
3222:
3193:
3183:
3158:
3129:
3100:
3062:
3044:
3019:
2981:
2980:
2960:
2954:
2953:
2943:
2919:
2913:
2912:
2902:
2891:10.7150/jca.9955
2869:
2863:
2862:
2841:
2835:
2834:
2798:
2792:
2791:
2763:
2757:
2756:
2720:
2714:
2713:
2703:
2671:
2665:
2664:
2654:
2622:
2616:
2615:
2587:
2581:
2580:
2544:
2538:
2537:
2501:
2495:
2494:
2458:
2449:
2448:
2412:
2403:
2402:
2374:
2368:
2367:
2357:
2325:
2319:
2318:
2290:
2281:
2280:
2270:
2238:
2232:
2231:
2221:
2189:
2183:
2182:
2172:
2140:
2134:
2133:
2123:
2113:
2089:
2083:
2082:
2046:
2040:
2039:
2029:
2005:
1999:
1998:
1988:
1956:
1950:
1949:
1939:
1915:
1909:
1908:
1872:
1863:
1862:
1843:10.1038/386463a0
1829:(6624): 463–71.
1818:
1812:
1811:
1801:
1769:
1760:
1759:
1731:
1725:
1724:
1717:
1711:
1710:
1703:
1697:
1696:
1667:
1661:
1660:
1649:
1643:
1642:
1631:
1625:
1615:
1604:
1594:
1543:, PSMA5, PSMB4,
1530:Sjögren syndrome
1290:Complex assembly
1213:
1212:
1184:
1177:
1160:
1148:
1139:
1115:
1111:RefSeq (protein)
1101:
1089:
1080:
1056:
1032:
1013:
987:
968:
942:
923:
892:
602:
588:
579:
572:
557:
525:ventricular zone
497:
495:Top expressed in
490:
455:endothelial cell
447:secondary oocyte
435:
433:Top expressed in
428:
407:
390:
380:
367:
356:
341:
334:
328:
317:
305:
289:
279:
266:
255:
240:
233:
227:
216:
202:
186:
180:
131:
124:
101:
64:
58:
37:
36:
31:
19:
4029:
4028:
4024:
4023:
4022:
4020:
4019:
4018:
4004:
4003:
4002:
3997:
3981:
3950:
3874:D (non-ATPases)
3869:
3828:
3767:
3716:
3706:
3676:
3671:
3668:
3662:
3648:
3645:
3615:
3585:(10): 5810–20.
3572:
3542:
3497:
3485:
3475:
3463:
3441:
3420:
3385:
3357:(1–2): 119–23.
3348:
3314:Nature Medicine
3311:
3281:(12): 10251–5.
3268:
3225:
3205:(1–2): 149–56.
3196:
3161:
3132:
3103:
3069:Electrophoresis
3065:
3022:
2993:
2989:
2987:Further reading
2984:
2962:
2961:
2957:
2921:
2920:
2916:
2871:
2870:
2866:
2853:(10): 2045–52.
2843:
2842:
2838:
2800:
2799:
2795:
2765:
2764:
2760:
2722:
2721:
2717:
2686:(8): 997–1004.
2673:
2672:
2668:
2624:
2623:
2619:
2589:
2588:
2584:
2546:
2545:
2541:
2503:
2502:
2498:
2460:
2459:
2452:
2414:
2413:
2406:
2376:
2375:
2371:
2327:
2326:
2322:
2292:
2291:
2284:
2247:Cell Metabolism
2240:
2239:
2235:
2204:(17): 2322–43.
2191:
2190:
2186:
2142:
2141:
2137:
2091:
2090:
2086:
2048:
2047:
2043:
2007:
2006:
2002:
1958:
1957:
1953:
1917:
1916:
1912:
1874:
1873:
1866:
1820:
1819:
1815:
1771:
1770:
1763:
1733:
1732:
1728:
1719:
1718:
1714:
1705:
1704:
1700:
1669:
1668:
1664:
1651:
1650:
1646:
1633:
1632:
1628:
1616:
1607:
1595:
1586:
1582:
1566:
1450:proto-oncogenes
1328:and subsequent
1314:
1305:
1292:
1275:
1270:
1257:
1222:View/Edit Mouse
1217:View/Edit Human
1180:
1173:
1170:Location (UCSC)
1156:
1135:
1131:
1127:
1123:
1097:
1076:
1072:
1068:
1064:
977:ENSG00000143106
870:
709:
643:
629:protein binding
584:
553:
544:
539:
535:
531:
527:
523:
519:
515:
511:
507:
493:
482:
477:
473:
469:
465:
461:
457:
453:
449:
445:
431:
375:
362:
354:
344:
343:
342:
335:
315:
292:Gene location (
274:
261:
253:
243:
242:
241:
234:
212:
189:Gene location (
140:
127:
120:
73:
51:
17:
12:
11:
5:
4027:
4025:
4017:
4016:
4006:
4005:
3999:
3998:
3996:
3995:
3989:
3987:
3983:
3982:
3980:
3979:
3974:
3969:
3964:
3958:
3956:
3952:
3951:
3949:
3948:
3943:
3938:
3933:
3928:
3923:
3918:
3913:
3908:
3903:
3898:
3893:
3888:
3883:
3877:
3875:
3871:
3870:
3868:
3867:
3862:
3857:
3852:
3847:
3842:
3836:
3834:
3830:
3829:
3827:
3826:
3821:
3816:
3811:
3806:
3801:
3796:
3791:
3786:
3781:
3775:
3773:
3769:
3768:
3766:
3765:
3760:
3755:
3750:
3745:
3740:
3735:
3730:
3724:
3722:
3718:
3717:
3707:
3705:
3704:
3697:
3690:
3682:
3673:
3672:
3670:
3669:
3663:
3656:
3653:
3650:
3649:
3646:
3644:
3643:
3636:
3629:
3621:
3614:
3613:
3570:
3540:
3495:
3487:|journal=
3461:
3439:
3418:
3383:
3346:
3309:
3266:
3223:
3194:
3174:(13): 8145–8.
3159:
3141:(1–2): 171–4.
3130:
3101:
3063:
3020:
2990:
2988:
2985:
2983:
2982:
2955:
2934:(8): 4286–97.
2914:
2864:
2836:
2793:
2758:
2715:
2666:
2637:(3): H337–49.
2617:
2582:
2539:
2496:
2450:
2404:
2369:
2340:(Pt A): 3–11.
2320:
2282:
2233:
2184:
2135:
2084:
2041:
2000:
1951:
1910:
1883:(11): 1062–7.
1864:
1813:
1761:
1726:
1712:
1698:
1662:
1644:
1626:
1605:
1583:
1581:
1578:
1565:
1562:
1524:patients with
1510:prostaglandins
1442:retinoblastoma
1362:Pick's disease
1326:ubiquitination
1313:
1310:
1304:
1301:
1291:
1288:
1274:
1271:
1269:
1266:
1256:
1253:
1236:also known as
1229:
1228:
1225:
1224:
1219:
1209:
1208:
1202:
1201:
1198:
1197:
1195:
1193:
1186:
1185:
1178:
1171:
1167:
1166:
1163:
1162:
1152:
1151:
1145:
1142:
1141:
1119:
1118:
1112:
1108:
1107:
1104:
1103:
1093:
1092:
1086:
1083:
1082:
1060:
1059:
1053:
1049:
1048:
1045:
1044:
1036:
1035:
1029:
1026:
1025:
1017:
1016:
1010:
1004:
1003:
1000:
999:
991:
990:
984:
981:
980:
972:
971:
965:
959:
958:
955:
954:
946:
945:
939:
936:
935:
927:
926:
920:
914:
913:
908:
903:
899:
898:
888:
887:
884:
883:
872:
871:
869:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
717:
715:
711:
710:
708:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
651:
649:
645:
644:
642:
641:
636:
631:
626:
621:
615:
613:
609:
608:
598:
597:
594:
593:
590:
589:
581:
580:
569:
563:
562:
559:
558:
550:
549:
546:
545:
543:
542:
538:
534:
530:
526:
522:
518:
514:
510:
506:
502:
499:
498:
487:
484:
483:
481:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
437:
436:
424:
423:
415:
404:
398:
397:
394:RNA expression
386:
385:
382:
381:
373:
369:
368:
360:
357:
352:
346:
345:
336:
329:
323:
319:
318:
313:
307:
306:
298:
297:
285:
284:
281:
280:
272:
268:
267:
259:
256:
251:
245:
244:
235:
228:
222:
218:
217:
210:
204:
203:
195:
194:
182:
181:
138:
134:
133:
125:
117:
116:
112:
111:
108:
107:
104:
103:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4026:
4015:
4012:
4011:
4009:
3994:
3991:
3990:
3988:
3984:
3978:
3975:
3973:
3970:
3968:
3965:
3963:
3960:
3959:
3957:
3953:
3947:
3944:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3917:
3914:
3912:
3909:
3907:
3904:
3902:
3899:
3897:
3894:
3892:
3889:
3887:
3884:
3882:
3879:
3878:
3876:
3872:
3866:
3863:
3861:
3858:
3856:
3853:
3851:
3848:
3846:
3843:
3841:
3838:
3837:
3835:
3831:
3825:
3822:
3820:
3817:
3815:
3812:
3810:
3807:
3805:
3802:
3800:
3797:
3795:
3792:
3790:
3787:
3785:
3782:
3780:
3777:
3776:
3774:
3770:
3764:
3761:
3759:
3756:
3754:
3751:
3749:
3746:
3744:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3725:
3723:
3719:
3714:
3710:
3703:
3698:
3696:
3691:
3689:
3684:
3683:
3680:
3666:
3660:
3655:
3651:
3642:
3637:
3635:
3630:
3628:
3623:
3622:
3619:
3610:
3606:
3601:
3596:
3592:
3588:
3584:
3580:
3576:
3571:
3567:
3563:
3559:
3555:
3552:(4): 771–82.
3551:
3547:
3541:
3537:
3533:
3529:
3525:
3521:
3517:
3513:
3509:
3505:
3501:
3496:
3492:
3480:
3472:
3468:
3464:
3458:
3454:
3450:
3446:
3440:
3436:
3432:
3428:
3424:
3419:
3415:
3411:
3406:
3401:
3397:
3393:
3389:
3384:
3380:
3376:
3372:
3368:
3364:
3360:
3356:
3352:
3347:
3343:
3339:
3335:
3331:
3327:
3323:
3319:
3315:
3310:
3306:
3302:
3297:
3292:
3288:
3284:
3280:
3276:
3272:
3267:
3263:
3259:
3255:
3251:
3246:
3241:
3237:
3233:
3229:
3224:
3220:
3216:
3212:
3208:
3204:
3200:
3195:
3191:
3187:
3182:
3177:
3173:
3169:
3165:
3160:
3156:
3152:
3148:
3144:
3140:
3136:
3131:
3127:
3123:
3119:
3115:
3112:(3): 1785–9.
3111:
3107:
3102:
3098:
3094:
3090:
3086:
3082:
3078:
3075:(12): 960–9.
3074:
3070:
3064:
3060:
3056:
3052:
3048:
3043:
3038:
3034:
3030:
3026:
3021:
3017:
3013:
3009:
3005:
3001:
2997:
2992:
2991:
2986:
2978:
2974:
2970:
2966:
2959:
2956:
2951:
2947:
2942:
2937:
2933:
2929:
2925:
2918:
2915:
2910:
2906:
2901:
2896:
2892:
2888:
2885:(8): 646–54.
2884:
2880:
2876:
2868:
2865:
2860:
2856:
2852:
2848:
2840:
2837:
2832:
2828:
2824:
2820:
2816:
2812:
2808:
2804:
2797:
2794:
2789:
2785:
2781:
2777:
2774:(7): 307–15.
2773:
2769:
2762:
2759:
2754:
2750:
2746:
2742:
2738:
2734:
2731:(1): H1–H19.
2730:
2726:
2719:
2716:
2711:
2707:
2702:
2697:
2693:
2689:
2685:
2681:
2677:
2670:
2667:
2662:
2658:
2653:
2648:
2644:
2640:
2636:
2632:
2628:
2621:
2618:
2613:
2609:
2605:
2601:
2597:
2593:
2586:
2583:
2578:
2574:
2570:
2566:
2562:
2558:
2554:
2550:
2543:
2540:
2535:
2531:
2527:
2523:
2519:
2515:
2511:
2507:
2500:
2497:
2492:
2488:
2484:
2480:
2476:
2472:
2468:
2464:
2457:
2455:
2451:
2446:
2442:
2438:
2434:
2430:
2426:
2422:
2418:
2411:
2409:
2405:
2400:
2396:
2392:
2388:
2384:
2380:
2373:
2370:
2365:
2361:
2356:
2351:
2347:
2343:
2339:
2335:
2331:
2324:
2321:
2316:
2312:
2308:
2304:
2300:
2296:
2289:
2287:
2283:
2278:
2274:
2269:
2264:
2260:
2256:
2253:(2): 215–26.
2252:
2248:
2244:
2237:
2234:
2229:
2225:
2220:
2215:
2211:
2207:
2203:
2199:
2195:
2188:
2185:
2180:
2176:
2171:
2166:
2162:
2158:
2154:
2150:
2146:
2139:
2136:
2131:
2127:
2122:
2117:
2112:
2107:
2103:
2099:
2095:
2088:
2085:
2080:
2076:
2072:
2068:
2064:
2060:
2057:(2): 905–31.
2056:
2052:
2045:
2042:
2037:
2033:
2028:
2023:
2019:
2015:
2011:
2004:
2001:
1996:
1992:
1987:
1982:
1978:
1974:
1970:
1966:
1962:
1955:
1952:
1947:
1943:
1938:
1933:
1930:(4): 372–80.
1929:
1925:
1921:
1914:
1911:
1906:
1902:
1898:
1894:
1890:
1889:10.1038/80992
1886:
1882:
1878:
1871:
1869:
1865:
1860:
1856:
1852:
1848:
1844:
1840:
1836:
1832:
1828:
1824:
1817:
1814:
1809:
1805:
1800:
1795:
1791:
1787:
1783:
1779:
1775:
1768:
1766:
1762:
1757:
1753:
1749:
1745:
1741:
1737:
1730:
1727:
1722:
1716:
1713:
1708:
1702:
1699:
1694:
1690:
1686:
1682:
1678:
1674:
1666:
1663:
1658:
1654:
1648:
1645:
1640:
1636:
1630:
1627:
1623:
1619:
1614:
1612:
1610:
1606:
1602:
1598:
1593:
1591:
1589:
1585:
1579:
1577:
1575:
1571:
1563:
1561:
1559:
1554:
1550:
1546:
1542:
1537:
1535:
1531:
1527:
1523:
1519:
1515:
1511:
1507:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1475:
1471:
1467:
1463:
1459:
1455:
1451:
1447:
1443:
1439:
1435:
1431:
1427:
1423:
1419:
1415:
1411:
1407:
1403:
1399:
1398:heart failure
1395:
1391:
1387:
1383:
1379:
1375:
1371:
1367:
1363:
1359:
1355:
1349:
1347:
1343:
1339:
1335:
1331:
1327:
1323:
1318:
1311:
1309:
1302:
1300:
1297:
1289:
1287:
1285:
1280:
1272:
1267:
1265:
1263:
1254:
1252:
1250:
1247:
1243:
1239:
1235:
1223:
1218:
1214:
1210:
1207:
1203:
1196:
1194:
1191:
1187:
1183:
1179:
1176:
1172:
1168:
1161:
1159:
1153:
1149:
1146:
1140:
1138:
1134:
1130:
1126:
1120:
1116:
1113:
1109:
1102:
1100:
1094:
1090:
1087:
1081:
1079:
1075:
1071:
1067:
1061:
1057:
1054:
1052:RefSeq (mRNA)
1050:
1043:
1042:
1037:
1033:
1030:
1024:
1023:
1018:
1014:
1011:
1009:
1005:
998:
997:
992:
988:
985:
979:
978:
973:
969:
966:
964:
960:
953:
952:
947:
943:
940:
934:
933:
928:
924:
921:
919:
915:
912:
909:
907:
904:
900:
897:
893:
889:
882:
878:
873:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
718:
716:
713:
712:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
652:
650:
647:
646:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
616:
614:
611:
610:
607:
606:Gene ontology
603:
599:
587:
582:
578:
573:
570:
568:
564:
556:
551:
540:
536:
532:
528:
524:
520:
516:
512:
508:
504:
503:
500:
496:
491:
488:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
441:
438:
434:
429:
426:
425:
422:
420:
416:
414:
413:
409:
408:
405:
403:
399:
395:
391:
387:
379:
374:
370:
366:
361:
351:
347:
340:
333:
327:
320:
312:
308:
304:
299:
295:
290:
286:
278:
273:
269:
265:
260:
250:
246:
239:
232:
226:
219:
215:
209:
205:
201:
196:
192:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
135:
130:
123:
118:
113:
102:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
3747:
3664:
3582:
3578:
3549:
3545:
3503:
3499:
3444:
3429:(1): 29–37.
3426:
3422:
3395:
3391:
3354:
3350:
3326:10.1038/3987
3317:
3313:
3278:
3274:
3238:(4): 331–3.
3235:
3231:
3202:
3198:
3171:
3167:
3138:
3134:
3109:
3105:
3072:
3068:
3035:(3): 281–3.
3032:
3028:
2999:
2995:
2971:(1): 29–37.
2968:
2964:
2958:
2931:
2927:
2917:
2882:
2878:
2867:
2850:
2846:
2839:
2806:
2802:
2796:
2771:
2767:
2761:
2728:
2724:
2718:
2683:
2679:
2669:
2634:
2630:
2620:
2598:(2): 103–8.
2595:
2591:
2585:
2555:(1): 78–85.
2552:
2548:
2542:
2509:
2505:
2499:
2466:
2462:
2420:
2416:
2385:(1): 133–8.
2382:
2378:
2372:
2337:
2333:
2323:
2301:(1): 85–98.
2298:
2294:
2250:
2246:
2236:
2201:
2197:
2187:
2152:
2148:
2138:
2101:
2097:
2087:
2054:
2050:
2044:
2020:(8): 503–8.
2017:
2013:
2003:
1971:(6): 352–9.
1968:
1964:
1954:
1927:
1923:
1913:
1880:
1876:
1826:
1822:
1816:
1781:
1777:
1739:
1735:
1729:
1715:
1701:
1679:(1): 29–38.
1676:
1672:
1665:
1656:
1647:
1638:
1629:
1567:
1564:Interactions
1538:
1514:nitric oxide
1350:
1346:malignancies
1319:
1315:
1306:
1293:
1278:
1276:
1258:
1245:
1237:
1233:
1232:
1155:
1133:NP_001186703
1129:NP_001186702
1125:NP_001186701
1122:
1096:
1078:NM_001199774
1074:NM_001199773
1070:NM_001199772
1063:
1039:
1020:
994:
975:
949:
930:
910:
905:
766:MAPK cascade
417:
410:
376:108,187,290
363:108,164,242
275:109,426,448
262:109,399,042
137:External IDs
72:
3833:C (ATPases)
3647:PDB gallery
2809:(1): 20–6.
2680:Circulation
2512:(1): 47–9.
2469:(1): 21–8.
1338:cell growth
1330:proteolysis
1262:class I MHC
761:proteolysis
680:nucleoplasm
533:neural tube
471:granulocyte
355:3|3 F3
115:Identifiers
3711:subunits (
3002:: 801–47.
1784:: 415–45.
1742:: 801–47.
1624:, May 2017
1603:, May 2017
1580:References
1506:P-selectin
1444:(Rb). and
1404:, such as
1334:cell cycle
1296:proteasome
1273:Expression
521:blastocyst
421:(ortholog)
158:HomoloGene
3715:3.4.25.1)
3489:ignored (
3479:cite book
1482:cytokines
1342:apoptosis
1303:Mechanism
1277:The gene
1268:Structure
1158:NP_036097
1137:NP_002781
1099:NM_011967
1066:NM_002790
896:Orthologs
685:cytoplasm
166:GeneCards
4008:Category
3609:12719574
3566:12419264
3528:12167863
3471:11771738
3435:11205743
3414:10893419
3379:27037791
3371:10363657
3342:25235070
3262:10732911
3097:41855774
3059:16340355
3051:12914693
2977:11205743
2950:22818443
2909:25157275
2859:12375310
2831:26973319
2823:11753406
2788:12654543
2745:16501026
2710:20159828
2661:23220331
2612:12792671
2569:12507416
2534:28190967
2491:22396490
2483:12070660
2437:11881748
2399:10899438
2364:25560147
2315:10723801
2277:25651176
2228:25133688
2179:24380730
2155:: 3–10.
2130:25324717
2079:14103185
2071:25561438
1995:24457024
1946:16857963
1905:27481109
1897:11062564
1808:23495936
1620:–
1599:–
1570:interact
1488:, IL-β,
1484:such as
1392:injury,
1390:ischemic
1382:dementia
1255:Function
1206:Wikidata
875:Sources:
513:epiblast
475:monocyte
3536:4403228
3508:Bibcode
3334:9846577
3305:9811770
3254:9530635
3219:9373149
3190:9079628
3155:8125298
3126:7811265
3089:1286667
3016:8811196
2900:4142326
2753:7073263
2701:2857348
2652:3774499
2577:5780576
2526:1328965
2445:2211658
2355:4886828
2268:4317573
2219:4241867
2170:4011959
2121:4179678
2036:9383453
1986:4037451
1859:4261663
1851:9087403
1831:Bibcode
1799:3827779
1756:8811196
1693:1888762
1622:Ensembl
1601:Ensembl
1368:(ALS),
1242:protein
1008:UniProt
963:Ensembl
902:Species
881:QuickGO
700:cytosol
665:nucleus
396:pattern
154:1347009
122:Aliases
3946:PSMD14
3941:PSMD13
3936:PSMD12
3931:PSMD11
3926:PSMD10
3824:PSMB10
3607:
3600:154025
3597:
3564:
3534:
3526:
3500:Nature
3469:
3459:
3433:
3412:
3377:
3369:
3340:
3332:
3303:
3296:110608
3293:
3260:
3252:
3217:
3188:
3153:
3124:
3095:
3087:
3057:
3049:
3014:
2975:
2948:
2907:
2897:
2857:
2829:
2821:
2786:
2751:
2743:
2708:
2698:
2659:
2649:
2610:
2575:
2567:
2532:
2524:
2489:
2481:
2443:
2435:
2397:
2362:
2352:
2313:
2275:
2265:
2226:
2216:
2177:
2167:
2128:
2118:
2104:: 77.
2077:
2069:
2034:
1993:
1983:
1944:
1903:
1895:
1857:
1849:
1823:Nature
1806:
1796:
1754:
1691:
1508:) and
1502:VCAM-1
1498:ICAM-1
1192:search
1190:PubMed
1041:Q9Z2U1
1022:P28066
918:Entrez
567:BioGPS
529:morula
509:embryo
505:embryo
467:rectum
443:oocyte
254:1p13.3
146:176844
3993:PSMF1
3977:PSME4
3972:PSME3
3967:PSME2
3962:PSME1
3921:PSMD9
3916:PSMD8
3911:PSMD7
3906:PSMD6
3901:PSMD5
3896:PSMD4
3891:PSMD3
3886:PSMD2
3881:PSMD1
3865:PSMC6
3860:PSMC5
3855:PSMC4
3850:PSMC3
3845:PSMC2
3840:PSMC1
3819:PSMB9
3814:PSMB8
3809:PSMB7
3804:PSMB6
3799:PSMB5
3794:PSMB4
3789:PSMB3
3784:PSMB2
3779:PSMB1
3763:PSMA8
3758:PSMA7
3753:PSMA6
3748:PSMA5
3743:PSMA4
3738:PSMA3
3733:PSMA2
3728:PSMA1
3532:S2CID
3375:S2CID
3338:S2CID
3258:S2CID
3093:S2CID
3055:S2CID
2827:S2CID
2749:S2CID
2573:S2CID
2530:S2CID
2487:S2CID
2441:S2CID
2075:S2CID
1901:S2CID
1855:S2CID
1572:with
1549:PSMD1
1545:PSMB5
1541:PSMA1
1486:TNF-α
1426:STAT3
1422:c-Myc
1418:NF-ÎşB
1414:c-Fos
1410:c-jun
1279:PSMA5
1246:PSMA5
1240:is a
951:26442
911:Mouse
906:Human
877:Amigo
541:ileum
419:Mouse
412:Human
359:Start
294:Mouse
258:Start
191:Human
170:PSMA5
129:PSMA5
22:PSMA5
3665:1iru
3605:PMID
3562:PMID
3524:PMID
3491:help
3467:PMID
3457:ISBN
3431:PMID
3410:PMID
3367:PMID
3330:PMID
3301:PMID
3250:PMID
3215:PMID
3199:Gene
3186:PMID
3151:PMID
3135:Gene
3122:PMID
3085:PMID
3047:PMID
3029:Cell
3012:PMID
2973:PMID
2946:PMID
2905:PMID
2855:PMID
2819:PMID
2784:PMID
2741:PMID
2706:PMID
2657:PMID
2608:PMID
2565:PMID
2522:PMID
2479:PMID
2433:PMID
2395:PMID
2383:1502
2360:PMID
2311:PMID
2273:PMID
2224:PMID
2175:PMID
2126:PMID
2067:PMID
2032:PMID
1991:PMID
1942:PMID
1893:PMID
1847:PMID
1804:PMID
1752:PMID
1689:PMID
1677:1079
1574:PLK1
1547:and
1532:and
1512:and
1490:IL-8
1396:and
1360:and
1294:The
1249:gene
932:5686
517:lens
402:Bgee
350:Band
311:Chr.
249:Band
208:Chr.
162:2084
142:OMIM
99:5A0Q
95:3UNH
91:3UNF
87:3UNE
83:3UNB
79:4R67
75:4R3O
56:RCSB
53:PDBe
3595:PMC
3587:doi
3554:doi
3550:323
3516:doi
3504:418
3449:doi
3400:doi
3396:275
3359:doi
3322:doi
3291:PMC
3283:doi
3240:doi
3207:doi
3203:200
3176:doi
3172:272
3143:doi
3139:138
3114:doi
3110:205
3077:doi
3037:doi
3033:114
3004:doi
2936:doi
2895:PMC
2887:doi
2811:doi
2776:doi
2733:doi
2729:291
2696:PMC
2688:doi
2684:121
2647:PMC
2639:doi
2635:304
2600:doi
2557:doi
2514:doi
2510:139
2471:doi
2467:104
2425:doi
2387:doi
2350:PMC
2342:doi
2303:doi
2263:PMC
2255:doi
2214:PMC
2206:doi
2165:PMC
2157:doi
2116:PMC
2106:doi
2059:doi
2022:doi
1981:PMC
1973:doi
1932:doi
1885:doi
1839:doi
1827:386
1794:PMC
1786:doi
1744:doi
1681:doi
1556:of
1526:SLE
1518:CDK
1478:ABL
1474:Mos
1470:Src
1466:Rel
1462:Myb
1458:Myc
1454:Raf
1438:APC
1406:p53
372:End
271:End
174:OMA
150:MGI
46:PDB
4010::
3713:EC
3603:.
3593:.
3583:77
3581:.
3577:.
3560:.
3548:.
3530:.
3522:.
3514:.
3502:.
3483::
3481:}}
3477:{{
3465:.
3455:.
3427:12
3425:.
3408:.
3394:.
3390:.
3373:.
3365:.
3355:26
3353:.
3336:.
3328:.
3316:.
3299:.
3289:.
3279:72
3277:.
3273:.
3256:.
3248:.
3234:.
3230:.
3213:.
3201:.
3184:.
3170:.
3166:.
3149:.
3137:.
3120:.
3108:.
3091:.
3083:.
3073:13
3071:.
3053:.
3045:.
3031:.
3027:.
3010:.
3000:65
2998:.
2969:12
2967:.
2944:.
2932:95
2930:.
2926:.
2903:.
2893:.
2881:.
2877:.
2851:29
2849:.
2825:.
2817:.
2805:.
2782:.
2770:.
2747:.
2739:.
2727:.
2704:.
2694:.
2682:.
2678:.
2655:.
2645:.
2633:.
2629:.
2606:.
2596:16
2594:.
2571:.
2563:.
2551:.
2528:.
2520:.
2508:.
2485:.
2477:.
2465:.
2453:^
2439:.
2431:.
2421:24
2419:.
2407:^
2393:.
2381:.
2358:.
2348:.
2338:23
2336:.
2332:.
2309:.
2299:12
2297:.
2285:^
2271:.
2261:.
2251:21
2249:.
2245:.
2222:.
2212:.
2202:21
2200:.
2196:.
2173:.
2163:.
2153:71
2151:.
2147:.
2124:.
2114:.
2100:.
2096:.
2073:.
2065:.
2055:53
2053:.
2030:.
2016:.
2012:.
1989:.
1979:.
1969:24
1967:.
1963:.
1940:.
1928:99
1926:.
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