1168:
The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified.
244:
221:
118:
143:
509:
502:
495:
250:
149:
2408:
1167:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits.
2014:
Huang X, Seifert U, Salzmann U, Henklein P, Preissner R, Henke W, Sijts AJ, Kloetzel PM, Dubiel W (2002). "The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing".
1757:"Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes"
1283:
Albertsen HM, Smith SA, Mazoyer S, Fujimoto E, Stevens J, Williams B, Rodriguez P, Cropp CS, Slijepcevic P, Carlson M (Dec 1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21".
1559:
Harshman K, Bell R, Rosenthal J, Katcher H, Miki Y, Swenson J, Gholami Z, Frye C, Ding W, Dayananth P (1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene".
1833:
Wรณjcik C, Tanaka K, Paweletz N, Naab U, Wilk S (1999). "Proteasome activator (PA28) subunits, alpha, beta and gamma (Ki antigen) in NT2 neuronal precursor cells and HeLa S3 cells".
257:
156:
2125:
1681:
McCusker D, Jones T, Sheer D, Trowsdale J (1998). "Genetic relationships of the genes encoding the human proteasome beta subunits and the proteasome PA28 complex".
1644:
Kandil E, Kohda K, Ishibashi T, Tanaka K, Kasahara M (1997). "PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes".
1588:
Jacob A, Kandpal G, Patanjali SR, Kandpal RP (1995). "Molecular cloning and expression pattern of genes from a 470 Kb region near BRCA1 locus on chromosome 17q21".
2097:
1475:"Cloning and nucleotide sequence of cDNA for Ki antigen, a highly conserved nuclear protein detected with sera from patients with systemic lupus erythematosus"
862:
843:
79:
1969:
Sheehy AM, Gaddis NC, Choi JD, Malim MH (2002). "Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein".
1710:
Knowlton JR, Johnston SC, Whitby FG, Realini C, Zhang Z, Rechsteiner M, Hill CP (1998). "Structure of the proteasome activator REGalpha (PA28alpha)".
2477:
2453:
2472:
1265:
1247:
1936:"Yeast two-hybrid screening using constitutive-active caspase-7 as bait in the identification of PA28gamma as an effector caspase substrate"
243:
1093:
2051:
1086:
220:
2090:
1330:
2106:
1234:
1213:
142:
117:
1230:
2063:
1209:
2083:
1516:
Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W (1994).
59:
1177:
256:
155:
1862:
Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype".
2446:
1792:"An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein"
249:
148:
2110:
907:
67:
888:
2075:
2439:
1473:
Nikaido T, Shimada K, Shibata M, Hata M, Sakamoto M, Takasaki Y, Sato C, Takahashi T, Nishida Y (1990).
131:
1978:
1719:
1529:
46:
2069:
2057:
1040:
1036:
989:
977:
2002:
1887:
1743:
1669:
1461:
1309:
91:
1401:
Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes".
1069:
1048:
1044:
1010:
985:
981:
643:
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
2032:
1994:
1957:
1922:
1879:
1850:
1821:
1778:
1735:
1698:
1661:
1632:
1597:
1576:
1547:
1504:
1453:
1418:
1378:
1301:
508:
501:
494:
39:
2423:
2024:
1986:
1947:
1912:
1871:
1842:
1811:
1803:
1768:
1727:
1690:
1653:
1622:
1568:
1537:
1494:
1486:
1443:
1410:
1368:
1360:
1293:
336:
267:
211:
166:
87:
1349:"Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation"
311:
1331:"Entrez Gene: PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)"
1982:
1723:
1533:
1414:
50:, HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA, proteasome activator subunit 3
1807:
1499:
1490:
1474:
1373:
1348:
2028:
1846:
1816:
1791:
1448:
1431:
777:
772:
767:
762:
757:
752:
747:
742:
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722:
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712:
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560:
555:
550:
2466:
2419:
537:
1891:
1673:
1465:
1313:
71:
2006:
1747:
1611:"HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation"
329:
108:
758:
regulation of transcription from RNA polymerase II promoter in response to hypoxia
1773:
1756:
95:
1518:"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1"
1270:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1252:
National Center for
Biotechnology Information, U.S. National Library of Medicine
412:
228:
125:
75:
1627:
1610:
1542:
1517:
807:
472:
350:
295:
282:
194:
181:
83:
2036:
1998:
1961:
1952:
1935:
1926:
1917:
1900:
1694:
1572:
1457:
1382:
1883:
1854:
1825:
1782:
1755:
Kohda K, Ishibashi T, Shimbara N, Tanaka K, Matsuda Y, Kasahara M (1998).
1739:
1702:
1665:
1657:
1636:
1601:
1580:
1551:
1508:
1422:
1364:
1305:
1133:
1128:
1117:
952:
933:
1990:
1297:
1149:
919:
874:
748:
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
2343:
2338:
2333:
2328:
2323:
2221:
1101:
829:
2407:
2390:
2374:
2364:
2359:
2318:
2313:
2308:
2303:
2298:
2293:
2288:
2283:
2278:
2262:
2257:
2252:
2247:
2242:
2237:
2216:
2211:
2206:
2201:
2196:
2191:
2186:
2181:
2176:
2160:
2155:
2150:
2145:
2140:
2135:
2130:
1731:
1875:
1432:"Death by deamination: a novel host restriction system for HIV-1"
792:
788:
723:
proteasome-mediated ubiquitin-dependent protein catabolic process
2415:
1185:
1156:
517:
63:
2079:
1181:
738:
negative regulation of G2/M transition of mitotic cell cycle
658:
negative regulation of extrinsic apoptotic signaling pathway
1901:"Degradation of HIV-1 integrase by the N-end rule pathway"
319:
2427:
713:
negative regulation of canonical Wnt signaling pathway
703:
anaphase-promoting complex-dependent catabolic process
653:
positive regulation of canonical Wnt signaling pathway
768:
regulation of hematopoietic stem cell differentiation
484:
668:
stimulatory C-type lectin receptor signaling pathway
2383:
2352:
2271:
2230:
2169:
2118:
1062:
1029:
1003:
970:
733:
Wnt signaling pathway, planar cell polarity pathway
688:
regulation of G1/S transition of mitotic cell cycle
638:
regulation of cellular amino acid metabolic process
633:
regulation of proteasomal protein catabolic process
1226:
1224:
1222:
1205:
1203:
1201:
778:regulation of mitotic cell cycle phase transition
266:
165:
673:tumor necrosis factor-mediated signaling pathway
1609:Seeger M, Ferrell K, Frank R, Dubiel W (1997).
1342:
1340:
1231:GRCm38: Ensembl release 89: ENSMUSG00000078652
2447:
2091:
718:positive regulation of endopeptidase activity
8:
1210:GRCh38: Ensembl release 89: ENSG00000131467
2454:
2440:
2098:
2084:
2076:
803:
533:
307:
206:
103:
1951:
1916:
1815:
1772:
1626:
1541:
1498:
1447:
1372:
1325:
1323:
773:interleukin-1-mediated signaling pathway
1934:Araya R, Takahashi R, Nomura Y (2002).
1197:
763:post-translational protein modification
1146:Proteasome activator complex subunit 3
20:
683:Fc-epsilon receptor signaling pathway
271:
232:
227:
170:
129:
124:
7:
2404:
2402:
1415:10.1146/annurev.bi.65.070196.004101
2426:. You can help Knowledge (XXG) by
1808:10.1128/JVI.72.12.10251-10255.1998
1491:10.1111/j.1365-2249.1990.tb05180.x
1059:
1026:
1000:
967:
943:
924:
898:
879:
853:
834:
489:
407:
345:
324:
14:
1152:that in humans is encoded by the
708:T cell receptor signaling pathway
2406:
2107:Proteasome endopeptidase complex
561:endopeptidase activator activity
556:MDM2/MDM4 family protein binding
507:
500:
493:
255:
248:
242:
219:
154:
147:
141:
116:
2478:Human chromosome 17 gene stubs
1899:Mulder LC, Muesing MA (2000).
518:More reference expression data
473:More reference expression data
1:
2029:10.1016/S0022-2836(02)00998-1
1847:10.1016/s0171-9335(98)80083-6
1449:10.1016/S0092-8674(03)00602-0
1347:Zhang Z, Zhang R (Mar 2008).
240:
139:
2473:Genes on human chromosome 17
1774:10.4049/jimmunol.160.10.4923
648:regulation of mRNA stability
592:proteasome activator complex
2056:human gene location in the
369:stromal cell of endometrium
2494:
2401:
2068:human gene details in the
1790:Madani N, Kabat D (1998).
1094:Chr 11: 101.21 โ 101.21 Mb
663:protein polyubiquitination
393:mucosa of transverse colon
1266:"Mouse PubMed Reference:"
1248:"Human PubMed Reference:"
1132:
1127:
1123:
1116:
1100:
1081:
1066:
1033:
1022:
1007:
974:
963:
950:
946:
931:
927:
918:
905:
901:
886:
882:
873:
860:
856:
841:
837:
828:
813:
806:
802:
786:
571:identical protein binding
536:
532:
515:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
1176:PSME3 has been shown to
1087:Chr 17: 42.82 โ 42.84 Mb
743:protein deubiquitination
1628:10.1074/jbc.272.13.8145
1543:10.1126/science.7545954
753:transmembrane transport
693:NIK/NF-kappaB signaling
18:Protein found in humans
2353:E (activator subunits)
1953:10.1038/SJ.CDD.4400949
1918:10.1074/jbc.M004670200
1695:10.1006/geno.1997.4948
2384:F (inhibitor subunit)
1658:10.1007/s002510050281
1365:10.1038/emboj.2008.25
273:11 D|11 64.67 cM
234:Chromosome 11 (mouse)
132:Chromosome 17 (human)
1573:10.1093/hmg/4.8.1259
377:gastrocnemius muscle
2070:UCSC Genome Browser
2058:UCSC Genome Browser
1991:10.1038/nature00939
1983:2002Natur.418..646S
1724:1997Natur.390..639K
1534:1994Sci...266...66M
459:seminiferous tubule
397:epithelium of colon
389:ganglionic eminence
385:mucosa of esophagus
361:islet of Langerhans
2414:This article on a
2119:A (alpha subunits)
1479:Clin. Exp. Immunol
1403:Annu. Rev. Biochem
1298:10.1038/ng0894-472
908:ENSMUSG00000078652
626:Biological process
602:proteasome complex
580:Cellular component
544:Molecular function
2435:
2434:
2399:
2398:
2170:B (beta subunits)
1940:Cell Death Differ
1835:Eur. J. Cell Biol
1143:
1142:
1139:
1138:
1112:
1111:
1077:
1076:
1056:
1055:
1018:
1017:
997:
996:
959:
958:
940:
939:
914:
913:
895:
894:
869:
868:
850:
849:
798:
797:
728:apoptotic process
528:
527:
524:
523:
479:
478:
466:
465:
404:
403:
302:
301:
201:
200:
96:PSME3 - orthologs
2485:
2456:
2449:
2442:
2410:
2403:
2100:
2093:
2086:
2077:
2040:
2010:
1977:(6898): 646โ50.
1965:
1955:
1930:
1920:
1911:(38): 29749โ53.
1895:
1870:(12): 1397โ400.
1858:
1829:
1819:
1786:
1776:
1751:
1718:(6660): 639โ43.
1706:
1677:
1640:
1630:
1605:
1584:
1555:
1545:
1512:
1502:
1469:
1451:
1430:Goff SP (2003).
1426:
1387:
1386:
1376:
1344:
1335:
1334:
1327:
1318:
1317:
1280:
1274:
1273:
1262:
1256:
1255:
1244:
1238:
1228:
1217:
1207:
1125:
1124:
1096:
1089:
1072:
1060:
1051:
1027:
1023:RefSeq (protein)
1013:
1001:
992:
968:
944:
925:
899:
880:
854:
835:
804:
534:
520:
511:
504:
497:
490:
475:
451:ventricular zone
443:genital tubercle
415:
413:Top expressed in
408:
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
49:
42:
21:
2493:
2492:
2488:
2487:
2486:
2484:
2483:
2482:
2463:
2462:
2461:
2460:
2400:
2395:
2379:
2348:
2272:D (non-ATPases)
2267:
2226:
2165:
2114:
2104:
2048:
2043:
2013:
1968:
1933:
1898:
1861:
1832:
1802:(12): 10251โ5.
1789:
1767:(10): 4923โ35.
1754:
1709:
1680:
1643:
1608:
1587:
1561:Hum. Mol. Genet
1558:
1528:(5182): 66โ71.
1515:
1472:
1429:
1400:
1396:
1394:Further reading
1391:
1390:
1346:
1345:
1338:
1329:
1328:
1321:
1282:
1281:
1277:
1264:
1263:
1259:
1246:
1245:
1241:
1229:
1220:
1208:
1199:
1194:
1174:
1165:
1134:View/Edit Mouse
1129:View/Edit Human
1092:
1085:
1082:Location (UCSC)
1068:
1047:
1043:
1039:
1035:
1009:
988:
984:
980:
976:
889:ENSG00000131467
782:
621:
575:
566:protein binding
516:
506:
505:
499:
498:
471:
462:
457:
453:
449:
445:
441:
437:
433:
431:ascending aorta
429:
425:
411:
400:
395:
391:
387:
383:
379:
375:
371:
367:
363:
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
19:
12:
11:
5:
2491:
2489:
2481:
2480:
2475:
2465:
2464:
2459:
2458:
2451:
2444:
2436:
2433:
2432:
2411:
2397:
2396:
2394:
2393:
2387:
2385:
2381:
2380:
2378:
2377:
2372:
2367:
2362:
2356:
2354:
2350:
2349:
2347:
2346:
2341:
2336:
2331:
2326:
2321:
2316:
2311:
2306:
2301:
2296:
2291:
2286:
2281:
2275:
2273:
2269:
2268:
2266:
2265:
2260:
2255:
2250:
2245:
2240:
2234:
2232:
2228:
2227:
2225:
2224:
2219:
2214:
2209:
2204:
2199:
2194:
2189:
2184:
2179:
2173:
2171:
2167:
2166:
2164:
2163:
2158:
2153:
2148:
2143:
2138:
2133:
2128:
2122:
2120:
2116:
2115:
2105:
2103:
2102:
2095:
2088:
2080:
2074:
2073:
2061:
2047:
2046:External links
2044:
2042:
2041:
2011:
1966:
1931:
1896:
1859:
1830:
1787:
1752:
1707:
1678:
1646:Immunogenetics
1641:
1621:(13): 8145โ8.
1606:
1585:
1567:(8): 1259โ66.
1556:
1513:
1470:
1427:
1397:
1395:
1392:
1389:
1388:
1336:
1319:
1275:
1257:
1239:
1218:
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1114:
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1110:
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1079:
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1057:
1054:
1053:
1031:
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1024:
1020:
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1016:
1015:
1005:
1004:
998:
995:
994:
972:
971:
965:
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960:
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948:
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929:
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635:
629:
627:
623:
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619:
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583:
581:
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513:
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468:
467:
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461:
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452:
448:
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432:
428:
427:tail of embryo
424:
420:
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405:
402:
401:
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382:
378:
374:
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362:
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354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
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286:
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99:
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35:
34:
30:
29:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
2490:
2479:
2476:
2474:
2471:
2470:
2468:
2457:
2452:
2450:
2445:
2443:
2438:
2437:
2431:
2429:
2425:
2421:
2420:chromosome 17
2417:
2412:
2409:
2405:
2392:
2389:
2388:
2386:
2382:
2376:
2373:
2371:
2368:
2366:
2363:
2361:
2358:
2357:
2355:
2351:
2345:
2342:
2340:
2337:
2335:
2332:
2330:
2327:
2325:
2322:
2320:
2317:
2315:
2312:
2310:
2307:
2305:
2302:
2300:
2297:
2295:
2292:
2290:
2287:
2285:
2282:
2280:
2277:
2276:
2274:
2270:
2264:
2261:
2259:
2256:
2254:
2251:
2249:
2246:
2244:
2241:
2239:
2236:
2235:
2233:
2229:
2223:
2220:
2218:
2215:
2213:
2210:
2208:
2205:
2203:
2200:
2198:
2195:
2193:
2190:
2188:
2185:
2183:
2180:
2178:
2175:
2174:
2172:
2168:
2162:
2159:
2157:
2154:
2152:
2149:
2147:
2144:
2142:
2139:
2137:
2134:
2132:
2129:
2127:
2124:
2123:
2121:
2117:
2112:
2108:
2101:
2096:
2094:
2089:
2087:
2082:
2081:
2078:
2071:
2067:
2066:
2062:
2059:
2055:
2054:
2050:
2049:
2045:
2038:
2034:
2030:
2026:
2023:(4): 771โ82.
2022:
2018:
2012:
2008:
2004:
2000:
1996:
1992:
1988:
1984:
1980:
1976:
1972:
1967:
1963:
1959:
1954:
1949:
1945:
1941:
1937:
1932:
1928:
1924:
1919:
1914:
1910:
1906:
1905:J. Biol. Chem
1902:
1897:
1893:
1889:
1885:
1881:
1877:
1873:
1869:
1865:
1860:
1856:
1852:
1848:
1844:
1841:(2): 151โ60.
1840:
1836:
1831:
1827:
1823:
1818:
1813:
1809:
1805:
1801:
1797:
1793:
1788:
1784:
1780:
1775:
1770:
1766:
1762:
1758:
1753:
1749:
1745:
1741:
1737:
1733:
1732:10.1038/37670
1729:
1725:
1721:
1717:
1713:
1708:
1704:
1700:
1696:
1692:
1688:
1684:
1679:
1675:
1671:
1667:
1663:
1659:
1655:
1652:(4): 337โ44.
1651:
1647:
1642:
1638:
1634:
1629:
1624:
1620:
1616:
1615:J. Biol. Chem
1612:
1607:
1603:
1599:
1595:
1591:
1586:
1582:
1578:
1574:
1570:
1566:
1562:
1557:
1553:
1549:
1544:
1539:
1535:
1531:
1527:
1523:
1519:
1514:
1510:
1506:
1501:
1496:
1492:
1488:
1485:(2): 209โ14.
1484:
1480:
1476:
1471:
1467:
1463:
1459:
1455:
1450:
1445:
1441:
1437:
1433:
1428:
1424:
1420:
1416:
1412:
1408:
1404:
1399:
1398:
1393:
1384:
1380:
1375:
1370:
1366:
1362:
1359:(6): 852โ64.
1358:
1354:
1350:
1343:
1341:
1337:
1332:
1326:
1324:
1320:
1315:
1311:
1307:
1303:
1299:
1295:
1291:
1287:
1279:
1276:
1271:
1267:
1261:
1258:
1253:
1249:
1243:
1240:
1236:
1232:
1227:
1225:
1223:
1219:
1215:
1211:
1206:
1204:
1202:
1198:
1191:
1189:
1187:
1183:
1179:
1171:
1169:
1162:
1160:
1158:
1155:
1151:
1147:
1135:
1130:
1126:
1122:
1119:
1115:
1108:
1106:
1103:
1099:
1095:
1091:
1088:
1084:
1080:
1073:
1071:
1065:
1061:
1058:
1052:
1050:
1046:
1042:
1038:
1032:
1028:
1025:
1021:
1014:
1012:
1006:
1002:
999:
993:
991:
987:
983:
979:
973:
969:
966:
964:RefSeq (mRNA)
962:
955:
954:
949:
945:
942:
936:
935:
930:
926:
923:
921:
917:
910:
909:
904:
900:
897:
891:
890:
885:
881:
878:
876:
872:
865:
864:
859:
855:
852:
846:
845:
840:
836:
833:
831:
827:
824:
821:
819:
816:
812:
809:
805:
801:
794:
790:
785:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
630:
628:
625:
624:
618:
615:
613:
610:
608:
605:
603:
600:
598:
595:
593:
590:
588:
585:
584:
582:
579:
578:
572:
569:
567:
564:
562:
559:
557:
554:
552:
549:
548:
546:
543:
542:
539:
538:Gene ontology
535:
531:
519:
514:
510:
503:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
16:
2428:expanding it
2413:
2369:
2064:
2052:
2020:
2017:J. Mol. Biol
2016:
1974:
1970:
1946:(3): 322โ8.
1943:
1939:
1908:
1904:
1876:10.1038/3987
1867:
1863:
1838:
1834:
1799:
1795:
1764:
1760:
1715:
1711:
1689:(2): 362โ7.
1686:
1682:
1649:
1645:
1618:
1614:
1596:(5): 981โ6.
1593:
1589:
1564:
1560:
1525:
1521:
1482:
1478:
1442:(3): 281โ3.
1439:
1435:
1406:
1402:
1356:
1352:
1292:(4): 472โ9.
1289:
1285:
1278:
1269:
1260:
1251:
1242:
1175:
1172:Interactions
1166:
1153:
1145:
1144:
1067:
1041:NP_001317158
1037:NP_001253974
1034:
1008:
990:NM_001330229
978:NM_001267045
975:
951:
932:
906:
887:
861:
842:
822:
817:
678:MAPK cascade
455:spermatocyte
439:aortic valve
335:
328:
294:101,214,363
281:101,207,039
55:External IDs
15:
2231:C (ATPases)
597:nucleoplasm
551:p53 binding
193:42,843,760
180:42,824,385
33:Identifiers
2467:Categories
2109:subunits (
1761:J. Immunol
1409:: 801โ47.
1237:, May 2017
1216:, May 2017
1192:References
698:cell cycle
339:(ortholog)
76:HomoloGene
2418:on human
2113:3.4.25.1)
1286:Nat Genet
1070:NP_035322
1049:NP_789839
1045:NP_005780
1011:NM_011192
986:NM_176863
982:NM_005789
808:Orthologs
612:cytoplasm
84:GeneCards
2037:12419264
1999:12167863
1962:11859414
1927:10893419
1892:25235070
1864:Nat. Med
1796:J. Virol
1683:Genomics
1674:22101213
1590:Oncogene
1466:16340355
1458:12914693
1383:18309296
1314:11075629
1233:–
1212:–
1178:interact
1163:Function
1118:Wikidata
787:Sources:
587:membrane
447:epiblast
435:yolk sac
381:appendix
365:monocyte
172:17q21.31
2007:4403228
1979:Bibcode
1884:9846577
1855:9840465
1826:9811770
1783:9590240
1748:4309279
1740:9403698
1720:Bibcode
1703:9344661
1666:9218537
1637:9079628
1602:7675458
1581:7581362
1552:7545954
1530:Bibcode
1522:Science
1509:1968796
1500:1534747
1423:8811196
1374:2265109
1306:7951316
1235:Ensembl
1214:Ensembl
1150:protein
920:UniProt
875:Ensembl
814:Species
793:QuickGO
617:cytosol
607:nucleus
314:pattern
72:1096366
40:Aliases
2344:PSMD14
2339:PSMD13
2334:PSMD12
2329:PSMD11
2324:PSMD10
2222:PSMB10
2035:
2005:
1997:
1971:Nature
1960:
1925:
1890:
1882:
1853:
1824:
1817:110608
1814:
1781:
1746:
1738:
1712:Nature
1701:
1672:
1664:
1635:
1600:
1579:
1550:
1507:
1497:
1464:
1456:
1421:
1381:
1371:
1353:EMBO J
1312:
1304:
1104:search
1102:PubMed
953:P61290
934:P61289
830:Entrez
485:BioGPS
373:rectum
64:605129
2422:is a
2391:PSMF1
2375:PSME4
2370:PSME3
2365:PSME2
2360:PSME1
2319:PSMD9
2314:PSMD8
2309:PSMD7
2304:PSMD6
2299:PSMD5
2294:PSMD4
2289:PSMD3
2284:PSMD2
2279:PSMD1
2263:PSMC6
2258:PSMC5
2253:PSMC4
2248:PSMC3
2243:PSMC2
2238:PSMC1
2217:PSMB9
2212:PSMB8
2207:PSMB7
2202:PSMB6
2197:PSMB5
2192:PSMB4
2187:PSMB3
2182:PSMB2
2177:PSMB1
2161:PSMA8
2156:PSMA7
2151:PSMA6
2146:PSMA5
2141:PSMA4
2136:PSMA3
2131:PSMA2
2126:PSMA1
2065:PSME3
2053:PSME3
2003:S2CID
1888:S2CID
1744:S2CID
1670:S2CID
1462:S2CID
1310:S2CID
1180:with
1154:PSME3
1148:is a
863:19192
844:10197
823:Mouse
818:Human
789:Amigo
423:blood
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
88:PSME3
47:PSME3
24:PSME3
2424:stub
2416:gene
2033:PMID
1995:PMID
1958:PMID
1923:PMID
1880:PMID
1851:PMID
1822:PMID
1779:PMID
1736:PMID
1699:PMID
1662:PMID
1633:PMID
1598:PMID
1577:PMID
1548:PMID
1505:PMID
1454:PMID
1436:Cell
1419:PMID
1379:PMID
1302:PMID
1186:Mdm2
1184:and
1157:gene
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
80:2111
60:OMIM
2025:doi
2021:323
1987:doi
1975:418
1948:doi
1913:doi
1909:275
1872:doi
1843:doi
1812:PMC
1804:doi
1769:doi
1765:160
1728:doi
1716:390
1691:doi
1654:doi
1623:doi
1619:272
1569:doi
1538:doi
1526:266
1495:PMC
1487:doi
1444:doi
1440:114
1411:doi
1369:PMC
1361:doi
1294:doi
1182:P53
290:End
189:End
92:OMA
68:MGI
2469::
2111:EC
2031:.
2019:.
2001:.
1993:.
1985:.
1973:.
1956:.
1942:.
1938:.
1921:.
1907:.
1903:.
1886:.
1878:.
1866:.
1849:.
1839:77
1837:.
1820:.
1810:.
1800:72
1798:.
1794:.
1777:.
1763:.
1759:.
1742:.
1734:.
1726:.
1714:.
1697:.
1687:45
1685:.
1668:.
1660:.
1650:46
1648:.
1631:.
1617:.
1613:.
1594:11
1592:.
1575:.
1563:.
1546:.
1536:.
1524:.
1520:.
1503:.
1493:.
1483:79
1481:.
1477:.
1460:.
1452:.
1438:.
1434:.
1417:.
1407:65
1405:.
1377:.
1367:.
1357:27
1355:.
1351:.
1339:^
1322:^
1308:.
1300:.
1288:.
1268:.
1250:.
1221:^
1200:^
1188:.
1159:.
791:/
296:bp
283:bp
195:bp
182:bp
90:;
86::
82:;
78::
74:;
70::
66:;
62::
2455:e
2448:t
2441:v
2430:.
2099:e
2092:t
2085:v
2072:.
2060:.
2039:.
2027::
2009:.
1989::
1981::
1964:.
1950::
1944:9
1929:.
1915::
1894:.
1874::
1868:4
1857:.
1845::
1828:.
1806::
1785:.
1771::
1750:.
1730::
1722::
1705:.
1693::
1676:.
1656::
1639:.
1625::
1604:.
1583:.
1571::
1565:4
1554:.
1540::
1532::
1511:.
1489::
1468:.
1446::
1425:.
1413::
1385:.
1363::
1333:.
1316:.
1296::
1290:7
1272:.
1254:.
214:)
111:)
94::
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