3256:
D, Rahman P, Morgan A, Marzo-Ortega H, Bowness P, Gaffney K, Gaston JS, Smith M, Bruges-Armas J, Couto AR, Sorrentino R, Paladini F, Ferreira MA, Xu H, Liu Y, Jiang L, Lopez-Larrea C, Díaz-Peña R, López-Vázquez A, Zayats T, Band G, Bellenguez C, Blackburn H, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Corvin A, Craddock N, Deloukas P, Dronov S, Duncanson A, Edkins S, Freeman C, Gillman M, Gray E, Gwilliam R, Hammond N, Hunt SE, Jankowski J, Jayakumar A, Langford C, Liddle J, Markus HS, Mathew CG, McCann OT, McCarthy MI, Palmer CN, Peltonen L, Plomin R, Potter SC, Rautanen A, Ravindrarajah R, Ricketts M, Samani N, Sawcer SJ, Strange A, Trembath RC, Viswanathan AC, Waller M, Weston P, Whittaker P, Widaa S, Wood NW, McVean G, Reveille JD, Wordsworth BP, Brown MA, Donnelly P (July 2011).
253:
230:
1597:(-/-) mice die within 3 days of birth due to the pulmonary congestion and heart failure caused by a patent ductus arteriosus. The ductus operates in the fetus to shunt blood from the pulmonary artery to the proximal descending aorta thereby allowing blood from the heart's right ventricle to bypass the fetus's non-functioning lungs. The ductus must close at birth to allow blood flow into the lungs. In mice, this is accomplished by turning off the mechanism which maintains the ductus's patency. Continuous activation of EP
127:
152:
259:
158:
2027:
of the inner ear. Pre- and post-treatment of guinea pigs with an EP4 agonist significantly attenuated threshold shifts of auditory brain stem responses and significantly reduced the loss of outer hair cells caused by prior noise exposure. These findings indicate that EP4 is involved in mechanisms for
3798:
Mori K, Tanaka I, Kotani M, Miyaoka F, Sando T, Muro S, Sasaki Y, Nakagawa O, Ogawa Y, Usui T, Ozaki S, Ichikawa A, Narumiya S, Nakao K (June 1996). "Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester".
3255:
Evans DM, Spencer CC, Pointon JJ, Su Z, Harvey D, Kochan G, Oppermann U, Opperman U, Dilthey A, Pirinen M, Stone MA, Appleton L, Moutsianas L, Moutsianis L, Leslie S, Wordsworth T, Kenna TJ, Karaderi T, Thomas GP, Ward MM, Weisman MH, Farrar C, Bradbury LA, Danoy P, Inman RD, Maksymowych W, Gladman
2169:
and increased expression of EP4 at vertebral column sites of involvement. Thus, excessive EP4 activation may contribute to the pathological bone remodeling and deposition found in ankylosing spondylitis and the rs10440635 variant may predispose to this disease by influencing EP4's production or
4193:
Asano T, Shoda J, Ueda T, Kawamoto T, Todoroki T, Shimonishi M, Tanabe T, Sugimoto Y, Ichikawa A, Mutoh M, Tanaka N, Miwa M (April 2002). "Expressions of cyclooxygenase-2 and prostaglandin E-receptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and
1947:
receptor-depleted mice exhibit slower weight gain; reduced adiposity upon high fat diet challenge; and shortened life span. These deficiencies are associated with disrupted lipid metabolism due to impaired triglyceride clearance; this impaired triglyceride clearance may underlie the cited
1802:-selective agonists (ONO-AE1-734 and AGN205203). The DDS-inflicted lesions were associated with defective colon mucosa barrier function along with the overexpression of genes mediating inflammatory responses and under-expression of genes involved in mucosal repair and remodeling. EP
4128:
Mutoh M, Watanabe K, Kitamura T, Shoji Y, Takahashi M, Kawamori T, Tani K, Kobayashi M, Maruyama T, Kobayashi K, Ohuchida S, Sugimoto Y, Narumiya S, Sugimura T, Wakabayashi K (January 2002). "Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis".
1822:
epithelial cells to secrete bicarbonate (HCO3-) in mice and humans; this response neutralizes the acidic fluid flowing from the stomach thereby contributing to the process of intestinal ulcer healing. Activators of this receptor therefore may useful as anti-ulcer drugs.
3630:
Regan JW, Bailey TJ, Pepperl DJ, Pierce KL, Bogardus AM, Donello JE, Fairbairn CE, Kedzie KM, Woodward DF, Gil DW (August 1994). "Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype".
1297:
have the advantage of being selective for this receptor over other EP receptors and are relatively resistant to being metabolically degraded. They are in development as drugs for the potential treatment of various diseases including
4055:
Slipetz D, Buchanan S, Mackereth C, Brewer N, Pellow V, Hao C, Adam M, Abramovitz M, Metters KM (October 2001). "Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor: dependence on the C-terminal tail".
3904:
Desai S, April H, Nwaneshiudu C, Ashby B (December 2000). "Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration".
1330:, including grapiprant (CJ-023,423), ONO-AE3-208, GW627368X, AH23848, and ONO-AE2-227, are in development for possible clinical use as inhibitors of the progression of prostate, breast, colon, and lung cancers.
3145:
De Vito V, Salvadori M, Poapolathep A, Owen H, Rychshanova R, Giorgi M (October 2017). "Pharmacokinetic/pharmacodynamic evaluation of grapiprant in a carrageenan-induced inflammatory pain model in the rabbit".
1346:
based on its ability, upon activation, to relax the contraction of certain smooth muscle preparations and smooth muscle-containing tissues that have been pre-contracted by stimulation. When bound to PGE
3936:"Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors"
1478:). The activation of these pathways lead to variety of different types of functional responses depending on cell type, the pathways available in different cell types, and numerous other factors; EP
3979:"Prostaglandin E(2) regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts"
3233:
7223:
7050:
1617:
in the smooth muscle cells and media in mouse ductus fall. This closes the ductus thereby establishing normal post-fetal circulation of blood through the lungs. Based on studies using EP
3092:
Hori R, Nakagawa T, Sugimoto Y, Sakamoto T, Yamamoto N, Hamaguchi K, Ito J (June 2009). "Prostaglandin E receptor subtype EP4 agonist protects cochleae against noise-induced trauma".
4304:
3846:
Mukhopadhyay P, Geoghegan TE, Patil RV, Bhattacherjee P, Paterson CA (May 1997). "Detection of EP2, EP4, and FP receptors in human ciliary epithelial and ciliary muscle cells".
2254:, have been associated with Crohn's disease in three independent cohorts with the association between rs7720838 and Crohn's disease being replicated in other populations; and
2165:
in a population recruited from the United
Kingdom, Australia, and Canada. Ankylosing spondylitis is a chronic inflammatory disease involving excessive bone deposition in the
4215:
Kyveris A, Maruscak E, Senchyna M (March 2002). "Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR".
266:
165:
6516:
4095:"Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2"
2145:
for use in canine medicine to treat pain caused by inflammation such as that occurring in osteoarthritis; it is currently also under investigation for use in humans.
5454:
2111:
selective antagonist, CJ-023,423, was tested for its effectiveness in treating gastroduodenal ulcers in patients between 2006 and 2008 d with no results reported (
5656:
5651:
5646:
5641:
1887:
receptor agonists reduce the acute rejection of transplanted hearts, prolong the survival of heart-transplanted animals, and reduce cardiac damage in a model of
7216:
1696:
that serves to maintain mucosal barriers, clear mucosal surfaces of pathogens, and contribute to autoimmune and inflammatory disorders. Its activation also:
3875:
Cosme R, Lublin D, Takafuji V, Lynch K, Roche JK (July 2000). "Prostanoids in human colonic mucosa: effects of inflammation on PGE(2) receptor expression".
6386:
6776:
6771:
4272:
788:
88:
3716:
Foord SM, Marks B, Stolz M, Bufflier E, Fraser NJ, Lee MG (July 1996). "The structure of the prostaglandin EP4 receptor gene and related pseudogenes".
2545:
1569:
receptor function found in these studies does not necessarily indicate that in does so in humans since EP receptor functions can vary between species.
769:
9753:
6807:
6152:
4297:
2285:
has been associated with and increase rate of primary graft dysfunction in a multicentered cohort study of graph recipients of different ethnicities.
3225:
3189:
Okumura Y, Yamagishi T, Nukui S, Nakao K (March 2017). "Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist".
1565:
receptor antagonists and agonists in animals as well as animal and human tissues indicate that this receptor serves various functions. However, an EP
1474:, a transcription factor that controls genes coding for cytokines and other elements that regulate inflammation, cell growth, and cell survival (see
7209:
6767:
5553:
5548:
3258:"Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility"
6791:
6473:
6468:
6463:
5429:
3523:
2130:-induced headaches in health volunteers to determine if it is a potentially useful candidate for testing its effectiveness on clinical headaches (
2115:) and is currently being tested in the recruitment step for a phase 2 clinical trial to treat prostate, non-small cell lung, and breast cancers (
3558:
Duncan AM, Anderson LL, Funk CD, Abramovitz M, Adam M (February 1995). "Chromosomal localization of the human prostanoid receptor gene family".
1289:, rivenprost (ONO-4819), OOG-308, ONO-AE1-329, AGN205203, ONO-4819, CP-734,432m AE1-329, SC-19220, SC-51089, and EP4RAG bind to and stimulate EP
6847:
5717:
5544:
4150:
Kvirkvelia N, Vojnovic I, Warner TD, Athie-Morales V, Free P, Rayment N, Chain BM, Rademacher TW, Lund T, Roitt IM, Delves PJ (February 2002).
1439:
3747:"Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells"
6458:
5404:
2389:
1443:
2371:
9780:
9775:
5632:
5444:
4914:
4652:
4647:
4642:
4637:
4632:
4290:
2182:
252:
6445:
5094:
2455:"International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress"
2011:
promotes the growth of various types of cancer cells and therefore may play a role in the progression of certain types of human cancer.
1646:
1634:
1806:
thus appears to serve anti-inflammatory and protective functions in the colon and agonists of this receptor may be useful for treating
6350:
5319:
2028:
prostaglandin E(1) actions on the cochlea, and local EP4 agonist treatment may be a means for attenuating noise-induced hearing lose.
3687:
An S, Yang J, Xia M, Goetzl EJ (November 1993). "Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2".
3045:"Mice lacking prostaglandin E receptor subtype 4 manifest disrupted lipid metabolism attributable to impaired triglyceride clearance"
996:
229:
7019:
7014:
7009:
7004:
6999:
6994:
6989:
6984:
5207:
5002:
4997:
4992:
4628:
1003:
1645:; furthermore, prostaglandins or their analogs are used to keep the ductus open in neonates with congenital heart defects such as
6801:
6796:
5736:
5731:
4812:
4807:
3353:
Cornejo-García JA, Perkins JR, Jurado-Escobar R, García-Martín E, Agúndez JA, Viguera E, Pérez-Sánchez N, Blanca-López N (2016).
2960:
Bouayad A, Kajino H, Waleh N, Fouron JC, Andelfinger G, Varma DR, Skoll A, Vazquez A, Gobeil F, Clyman RI, Chemtob S (May 2001).
2519:
1704:(i.e. suppressor T cells that modulate the immune system to maintain tolerance to self-antigens and prevent autoimmune disease);
3412:
1760:
blood flow to cause, for example, site-specific signs of inflammation such as redness, heat, and swelling in rodent models; and
8199:
6980:
6887:
5741:
4987:
4742:
3497:
3468:
3442:
2358:
2337:
2231:
1415:
2523:
6836:
6831:
6365:
5606:
5601:
5449:
5298:
5293:
2780:
Moreno JJ (February 2017). "Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithelial homeostasis".
2278:
2154:
1852:
1391:
2354:
151:
126:
6370:
4152:"Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells"
1790:
receptors are highly expressed in the small intestine and colon. Mice lacking this receptor or treated with a selective EP
4014:"Agonist-induced internalization and mitogen-activated protein kinase activation of the human prostaglandin EP4 receptor"
2333:
1641:, are used to reduce prostaglandin production and thereby close the ductus in neonates, infants, and older patients with
1124:
The PTGER4 gene is located on human chromosome 5p13.1 at position p13.1 (i.e. 5p13.1), contains 7 exons, and codes for a
9746:
6827:
5167:
5162:
4398:
4393:
4388:
4378:
4373:
4368:
4237:
2631:"Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy"
2142:
1716:
located primarily in the skin and mucous membranes) to mature, migrate, and direct the early stage of immune responses;
1546:
68:
7338:
7281:
6361:
4928:
4923:
4384:
4364:
1912:
1904:
1888:
1848:
265:
164:
7852:
2101:
3012:
Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y (December 2014). "Prostanoid receptors and acute inflammation in skin".
2498:
9703:
7646:
7569:
7462:
5361:
5356:
5212:
5202:
5197:
5182:
5177:
5150:
4976:
4971:
4966:
4877:
4414:
4409:
4404:
4317:
2411:
2304:
2299:
2294:
2041:
1996:
1807:
1526:
1501:
1494:
1487:
1125:
258:
157:
2680:
Narumiya S, Sugimoto Y, Ushikubi F (October 1999). "Prostanoid receptors: structures, properties, and functions".
1533:
becomes insensitive to further activation and internalizes. This effect limits the duration and extent to which EP
7444:
7263:
5398:
5393:
5388:
5158:
5044:
4872:
4854:
4835:
4828:
4347:
8163:
4238:"Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells"
9540:
9521:
9476:
7918:
6953:
6822:
6782:
6428:
5352:
5314:
5173:
4962:
4886:
4840:
4330:
2116:
2112:
2077:
stimulators (i.e. agonists) or inhibitors (i.e. antagonists) that have been conducted or are underway include:
1642:
1482:
activation may therefore have diverse effects on cell function depending on these factors. In many respects, EP
1451:
1423:
1129:
833:
76:
7246:
5686:
5681:
5676:
5671:
5666:
5626:
5621:
5538:
5533:
5528:
5518:
5384:
5268:
5236:
5231:
5193:
5188:
5099:
4823:
2537:
1892:
1713:
1462:
also interacts with
Prostaglandin E receptor 4-associated protein (EPRAP) to inhibit phosphorylation of the
1282:
1165:
1109:
814:
8304:
1983:
inhibit the in vitro proliferation and invasiveness of human breast cancer cells. And, gene knockdown of EP
1927:, that develops within 23–33 weeks after birth in mice. These studies are interpreted as indicating that EP
9582:
9502:
5339:
5334:
5251:
5246:
4845:
4446:
4441:
2162:
2070:
1924:
1780:
1745:
1471:
1419:
1343:
1311:
1303:
1172:
1070:
3654:"Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype"
1794:
antagonist proved to be far more susceptible to the development of dextran sodium sulphate (DSS)-induced
1633:
may play minor parts in maintaining patency of the ductus. These studies also appear relevant to humans:
9559:
8015:
7252:
6884:
5722:
5706:
5701:
5696:
5662:
5617:
5514:
5377:
5372:
5324:
5227:
5222:
5009:
4893:
4736:
4731:
4726:
4715:
4710:
4705:
4700:
4451:
4436:
4313:
1900:
1435:
1278:
3535:
1843:(i.e. cells responsible for bone absorption) to differentiate from precursor cells and is required for
9064:
9034:
8865:
2131:
9698:
8820:
8673:
8143:
7981:
7890:
6934:
6592:
5904:
5727:
5712:
5578:
5573:
5568:
5289:
5242:
4919:
4898:
4683:
4678:
4673:
4668:
4663:
4282:
3758:
2580:
1765:
1622:
1515:
1363:
1149:
1116:
has been implicated in various physiological and pathological responses in animal models and humans.
140:
8070:
7690:
3587:
Wu H, Wu T, Hua W, Dong X, Gao Y, Zhao X, Chen W, Cao W, Yang Q, Qi J, Zhou J, Wang J (March 2015).
55:
8917:
8897:
8648:
8453:
8403:
6757:
5692:
5583:
5367:
5330:
4795:
4424:
4356:
2309:
2202:
1323:
1191:
1157:
975:
924:
9223:
8688:
8578:
8573:
8558:
8493:
8443:
8398:
7963:
9630:
9510:
9461:
9451:
8875:
8553:
8533:
8518:
8508:
8488:
8483:
8438:
8413:
8378:
8224:
8055:
7833:
7731:
7670:
7631:
7430:
7420:
7328:
7238:
6976:
6487:
6311:
5423:
5418:
5413:
5347:
4722:
4695:
4432:
4081:
4043:
3834:
3330:
3171:
3127:
3074:
2991:
2805:
2705:
2246:
rs4495224, an A/C SNP variant, and rs7720838, both of which are projected to be binding sites in
2045:
1811:
1299:
100:
9660:
9655:
9620:
9595:
9456:
9317:
9174:
8775:
8770:
8568:
8548:
8543:
8538:
8523:
8513:
8503:
8478:
8468:
8463:
8458:
8448:
8433:
8428:
8388:
8347:
8327:
8284:
8279:
8264:
8254:
8249:
8234:
8113:
8035:
7990:
7904:
7880:
7870:
7318:
2239:
979:
954:
928:
903:
9645:
9600:
9411:
9357:
9342:
9191:
8902:
8850:
8735:
8583:
8528:
8498:
8473:
8423:
8418:
8408:
8393:
8342:
8337:
8294:
8229:
8219:
8189:
8133:
8103:
8060:
8050:
7899:
7823:
7675:
7588:
7385:
1875:
receptor mediates bone remolding in mice and, it is suggested, other animals including humans.
9650:
9625:
9615:
9466:
9441:
9426:
9391:
9367:
9362:
9113:
9044:
8713:
8683:
8563:
8383:
8317:
8289:
8274:
8269:
8244:
7860:
7828:
7808:
7751:
7636:
7559:
7554:
7549:
7544:
7380:
7375:
6842:
6786:
6432:
6162:
6157:
5612:
5309:
4658:
4257:
4224:
4203:
4181:
4138:
4116:
4073:
4035:
4000:
3977:
Faour WH, He Y, He QW, de
Ladurantaye M, Quintero M, Mancini A, Di Battista JA (August 2001).
3965:
3934:
Sales KJ, Katz AA, Davis M, Hinz S, Soeters RP, Hofmeyr MD, Millar RP, Jabbour HN (May 2001).
3922:
3892:
3863:
3826:
3786:
3733:
3704:
3675:
3640:
3618:
3575:
3386:
3322:
3287:
3206:
3163:
3119:
3066:
3025:
2983:
2942:
2901:
2857:
2797:
2757:
2697:
2662:
2606:
2476:
1701:
1650:
1618:
1582:
48:
9670:
9386:
9332:
9327:
8362:
8209:
8118:
8075:
7626:
7539:
7425:
7405:
7400:
7395:
2921:"Roles of prostanoids revealed from studies using mice lacking specific prostanoid receptors"
9726:
9718:
9713:
9532:
9436:
9431:
9017:
8603:
8239:
8204:
8094:
8080:
8040:
7973:
7799:
7790:
7722:
7713:
7705:
7607:
7598:
7520:
7511:
7362:
7300:
5637:
5559:
5409:
4249:
4171:
4163:
4106:
4065:
4025:
3990:
3955:
3947:
3914:
3884:
3855:
3816:
3808:
3776:
3766:
3725:
3696:
3665:
3608:
3600:
3567:
3376:
3366:
3314:
3277:
3269:
3198:
3155:
3109:
3101:
3056:
3017:
2973:
2932:
2891:
2847:
2839:
2789:
2747:
2689:
2652:
2642:
2596:
2588:
2466:
2186:
2166:
1538:
1508:
1395:
1355:
1258:
1074:
345:
276:
220:
175:
96:
8322:
8171:
3589:"PGE2 receptor agonist misoprostol protects brain against intracerebral hemorrhage in mice"
9574:
9506:
9416:
9091:
9069:
9039:
7736:
7030:
6817:
6626:
5915:
5597:
5564:
5304:
4601:
4586:
4581:
4576:
4566:
4561:
4556:
4551:
4546:
1916:
1729:
1202:
1176:
1153:
320:
3604:
3762:
2584:
1863:
into mice failed to stimulate bone absorption. Furthermore, the infusion of selective EP
1148:
in the heart and small intestine and to lesser extents in lung, kidney, thymus, uterus,
9096:
9049:
8614:
8176:
7235:
6903:
5763:
5591:
4818:
4611:
4606:
4596:
4572:
4542:
4537:
4176:
4151:
3960:
3935:
3613:
3588:
3381:
3354:
3282:
3257:
3105:
2852:
2827:
2657:
2630:
2601:
2568:
2097:
2096:(ONO-4819), improved the ulcerative colitis symptoms of 3 among 4 tested patients in a
1980:
1931:
plays both protective and damaging roles in the heart with the protective effects of EP
1709:
1685:
1681:
1677:
1590:
1387:
1379:
1209:
1206:
1169:
4069:
4030:
4013:
3888:
3859:
3670:
3653:
2978:
2961:
2007:
gene knockdown inhibits this growth. These results indicate that the stimulation of EP
1402:
which in turn activates signaling molecules, in particular, the transcription factor,
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
603:
587:
582:
577:
572:
556:
551:
541:
536:
9769:
9693:
9377:
9162:
9059:
8937:
8922:
8855:
8785:
6958:
6607:
6602:
6597:
5523:
5459:
4527:
4276:
4167:
3781:
3746:
3571:
3404:
2227:
1693:
1145:
523:
4085:
4047:
3838:
3489:
3464:
3434:
3334:
3131:
3078:
2995:
1907:
but also develop cardiac hypertrophy with poor cardiac function. Cardiac specific EP
1899:
receptor-depleted mice exhibit more severe cardiac damage in experimental models of
9233:
9150:
9076:
9054:
9007:
8942:
8912:
8892:
8887:
8810:
8698:
8123:
8085:
7953:
7780:
7616:
7501:
7308:
6880:
5278:
5272:
4882:
4867:
4690:
4457:
3175:
2809:
2709:
2693:
1773:
1638:
1427:
1411:
1307:
1161:
338:
117:
80:
7201:
2234:
found that SNP variant rs11742570 containing a C/T single-nucleotide variation in
2102:
https://clinicaltrials.gov/ct2/show/record/NCT00296556?term=rivenprost&rank=10
3021:
2793:
2752:
2735:
104:
9708:
9610:
9551:
9421:
9406:
9347:
9312:
9290:
9270:
9218:
9203:
9145:
9103:
9029:
8997:
8982:
8815:
8800:
8725:
8663:
8658:
8332:
8005:
7968:
7943:
7938:
7785:
7741:
7700:
7695:
7593:
7529:
7506:
7496:
7415:
7390:
7357:
7323:
3465:"PTGER4 prostaglandin e receptor 4 [Homo sapiens (Human)] - Gene - NCBI"
2962:"Characterization of PGE2 receptors in fetal and newborn lamb ductus arteriosus"
2495:"PTGER4 prostaglandin e receptor 4 [Homo sapiens (Human)] - Gene - NCBI"
2408:"PTGER3 prostaglandin e receptor 3 [Homo sapiens (Human)] - Gene - NCBI"
2394:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2376:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2263:
1868:
1486:
actions resemble those of another type of another relaxant prostanoid receptor,
1455:
1266:
1199:
1105:
4253:
3751:
Proceedings of the
National Academy of Sciences of the United States of America
3305:
Haroon N (June 2015). "Ankylosis in ankylosing spondylitis: current concepts".
3202:
1104:
and also, but generally with lesser affinity and responsiveness, certain other
421:
9640:
9401:
9372:
9352:
9305:
9300:
9285:
9260:
9228:
9196:
9167:
9123:
9022:
8972:
8967:
8962:
8957:
8932:
8845:
8840:
8780:
8765:
8745:
8730:
8703:
8678:
8668:
8653:
8643:
8357:
8312:
8299:
8214:
8000:
7995:
7948:
7885:
7865:
7818:
7410:
7232:
7182:
7098:
6325:
3318:
2198:
2194:
2161:
gene on human chromosome 5 has been associated with an increased incidence of
2126:
selective antagonist, BGC20-1531, is being tested for its ability to block PGE
1988:
1965:
1867:
agonists into mice stimulated increases in the number of bone osteoclasts and
1840:
1737:
1467:
1463:
1351:
1242:
1230:
1187:
237:
134:
84:
3771:
3371:
2843:
1960:
receptor is over-expressed in human prostate cancer tissue and a selective EP
9665:
9605:
9337:
9295:
9280:
9275:
9265:
9255:
9250:
9245:
9240:
9155:
9138:
9133:
9128:
9012:
8992:
8987:
8952:
8947:
8907:
8880:
8835:
8830:
8825:
8805:
8760:
8755:
8718:
8708:
8633:
8352:
8259:
8108:
8045:
7958:
7875:
7680:
7665:
7486:
7481:
6891:
6812:
4334:
3043:
Cai Y, Ying F, Song E, Wang Y, Xu A, Vanhoutte PM, Tang EH (December 2015).
2573:
Proceedings of the Japan
Academy. Series B, Physical and Biological Sciences
2117:
https://clinicaltrials.gov/ct2/show/NCT02538432?term=CJ-023%2C423&rank=2
2113:
https://clinicaltrials.gov/ct2/show/NCT00392080?term=CJ-023%2C423&rank=1
1991:
of murine breast cancer cells in a mouse model of induced breast cancer. PGE
1969:
1923:
only in cardiac muscle causes a somewhat different form of cardiac disease,
1769:
1757:
1753:
1733:
1689:
733:
546:
481:
359:
304:
291:
203:
190:
92:
4261:
4228:
4207:
4185:
4142:
4120:
4111:
4094:
4077:
4039:
4004:
3995:
3978:
3969:
3951:
3926:
3896:
3729:
3700:
3622:
3390:
3326:
3291:
3210:
3167:
3123:
3070:
3029:
2987:
2946:
2905:
2896:
2879:
2861:
2801:
2761:
2701:
2666:
2647:
2610:
2480:
2048:
or laser-induced choroidal neovascularization. This result suggests that EP
1776:) and has been used successfully to block the osteoarthritis pain in dogs.
1450:, a transcription factor which controls transcription of genes involved in
3918:
3867:
3830:
3790:
3737:
3708:
3679:
3644:
3579:
2569:"Molecular biology of histidine decarboxylase and prostaglandin receptors"
2471:
2454:
2197:
in response to NSAID consumption in individuals with a history of chronic
1859:(-/-) mice to re-absorb bone when induced to do so and the infusion of PGE
1043:
1038:
9498:
9493:
9322:
9184:
9179:
9118:
9108:
9086:
9081:
9002:
8977:
8927:
8870:
8860:
8795:
8790:
8750:
8065:
7685:
7491:
7116:
7094:
3061:
3044:
2494:
2407:
2251:
2174:
1844:
1819:
1798:
and to be protected from developing the colitis by pre-treatment with EP
1660:
function, colonies obtained by cross-breeding the 5% of mice surviving EP
1475:
1283:
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=343
1179:
1088:
in humans; it is one of four identified EP receptors, the others being EP
1027:
878:
859:
699:
adenylate cyclase-activating G protein-coupled receptor signaling pathway
614:
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
3534:. International Union of Basic and Clinical Pharmacology. Archived from
2592:
2538:"EP4 receptor - Prostanoid receptors - IUPHAR/BPS Guide to PHARMACOLOGY"
1871:
as well as increases in bone density. These studies indicate that the EP
9635:
9446:
9213:
8740:
8693:
8638:
8184:
6187:
5897:
5892:
5887:
5882:
5877:
5872:
5867:
5862:
5857:
5852:
5847:
5842:
5837:
5832:
5827:
5822:
5817:
5812:
5508:
5503:
5498:
5493:
4236:
Scandella E, Men Y, Gillessen S, Förster R, Groettrup M (August 2002).
3821:
3812:
3114:
2937:
2920:
2259:
2024:
1795:
1585:
as defined in mice lacking a functional gene for this receptor, i.e. EP
1213:
845:
800:
3159:
2223:
gene variations have been associated with inflammatory bowel disease:
1233:
have the following relative efficacies in binding to and activating EP
17:
9396:
8597:
7069:
7064:
7059:
7054:
7044:
7039:
7034:
7025:
6970:
6965:
6927:
6922:
6917:
6762:
6738:
6733:
6728:
6723:
6718:
6713:
6708:
6703:
6698:
6693:
6688:
6683:
6678:
6673:
6668:
6663:
6658:
6580:
6575:
6570:
6565:
6502:
6497:
6492:
6400:
6345:
6340:
6335:
6306:
6287:
6282:
6277:
6272:
6267:
6262:
6257:
6252:
6247:
6242:
6237:
6232:
6227:
6222:
6217:
6212:
6207:
6202:
6197:
6192:
6182:
6177:
6172:
6167:
6147:
5807:
5802:
5797:
5792:
5787:
5782:
5777:
5488:
5483:
5478:
5473:
5438:
5129:
4952:
4946:
4516:
4511:
4501:
4496:
2190:
2185:(NSAID)-exacerbated cutaneous disease (NECD). NECD is a non-allergic
1721:
1399:
1183:
1011:
755:
3652:
Bastien L, Sawyer N, Grygorczyk R, Metters KM, Adam M (April 1994).
2734:
Markovič T, Jakopin Ž, Dolenc MS, Mlinarič-Raščan I (January 2017).
2212:, and presumably thereby less of the anti-inflammatory effects of EP
1744:
increases the survival of neurons in an inflammation-based model of
3273:
2132:
https://clinicaltrials.gov/ct2/show/NCT00957983?term=EP4&rank=1
9208:
7165:
6856:
6851:
6653:
6648:
6643:
6638:
6614:
6560:
6555:
6550:
6395:
6390:
6380:
6375:
6316:
6142:
6137:
6132:
6127:
6122:
6117:
6112:
6107:
6102:
6097:
6092:
6087:
6082:
6077:
6072:
6067:
6062:
6057:
6052:
6047:
6042:
6037:
6032:
6027:
6022:
6017:
6012:
6007:
6002:
5997:
5992:
5987:
5982:
5977:
5972:
5967:
5962:
5957:
5952:
5947:
5468:
5433:
5283:
5123:
5118:
5113:
5108:
5103:
5089:
5083:
5078:
5073:
5068:
5063:
5058:
5053:
5048:
5038:
5033:
5028:
5023:
5018:
5013:
4981:
4941:
4936:
4859:
4771:
4766:
4761:
4756:
4751:
4746:
4506:
4491:
4486:
4481:
4476:
4471:
4466:
4461:
1606:
1407:
1195:
2878:
Korbecki J, Baranowska-Bosiacka I, Gutowska I, Chlubek D (2014).
2736:"Structural features of subtype-selective EP receptor modulators"
1128:(GPCR) of the rhodopsin-like receptor family, Subfamily A14 (see
718:
714:
7160:
7155:
7150:
7145:
7140:
7135:
7130:
7125:
7120:
6538:
6531:
6526:
6521:
6330:
6320:
5942:
5937:
5932:
5927:
5587:
5463:
4957:
2966:
American
Journal of Physiology. Heart and Circulatory Physiology
2056:
antagonists may be useful for treating neovascular eye disease.
2052:
activation contributes to corneal neovascularization and that EP
1447:
1403:
1254:
1250:
1246:
1141:
1085:
72:
7205:
7091:
6878:
6426:
4328:
4286:
1537:
can stimulate cells. Agents which activate certain isoforms of
6355:
2919:
Ushikubi F, Sugimoto Y, Ichikawa A, Narumiya S (August 2000).
2520:"Entrez Gene: PTGER4 prostaglandin E receptor 4 (subtype EP4)"
1935:
due at least in part to its ability to suppress inflammation.
1100:, all of which bind with and mediate cellular responses to PGE
3355:"Pharmacogenomics of Prostaglandin and Leukotriene Receptors"
1406:. Activated CREB stimulates the expression of genes such as
1152:, and brain. EP4 protein is found in humans as measured by
704:
positive regulation of cytosolic calcium ion concentration
328:
1768:
neurons from signaling inflammation-induced pain (i.e.
1561:
and supplemented by studies examining the actions of EP
1557:
Studies using animals genetically engineered to lack EP
1493:
but differs from the contractile prostanoid receptors,
2629:
Pang L, Cai Y, Tang EH, Irwin MG, Ma H, Xia Z (2016).
493:
59:, EP4, EP4R, EP4 receptor, prostaglandin E receptor 4
3940:
The
Journal of Clinical Endocrinology and Metabolism
2828:"Regulation of immune responses by prostaglandin E2"
2453:
Woodward DF, Jones RL, Narumiya S (September 2011).
2274:
as well as with the development of Crohn's disease.
2201:. The G allele at the -1254 position leads to lower
1651:
Ductus arteriosus#Disorder: Patent ductus arteriosus
1507:
receptors which mobilize G proteins containing the
9683:
9581:
9558:
9539:
9520:
9475:
8613:
8596:
8371:
8142:
8014:
7917:
7842:
7760:
7645:
7568:
7461:
7443:
7339:
7337:
7282:
7280:
7262:
7245:
7175:
7109:
6944:
6902:
6748:
6625:
6444:
6297:
5914:
5762:
5755:
5261:
5149:
5142:
4907:
4794:
4785:
4621:
4526:
4423:
4355:
4346:
3689:
3226:"Reference SNP (refSNP) Cluster Report: rs10440635"
3148:
Journal of Veterinary Pharmacology and Therapeutics
968:
947:
917:
896:
8620:
7762:
7647:
7570:
7463:
2350:
2348:
2346:
2329:
2327:
2325:
1581:plays a critical role in postnatal closure of the
1470:, thereby suppressing a cells ability to activate
1446:pathways. Activation of ERK induces expression of
1370:) complex. The complex then dissociate into its Gα
1285:). Several synthetic compounds, e.g. 1-hydroxy-PGE
1273:, has the same binding affinity and potency for EP
7445:
7264:
1855:-induced osteoclast formation; bone taken from EP
275:
174:
9541:
9522:
9477:
7919:
3348:
3346:
3344:
3007:
3005:
2873:
2871:
2821:
2819:
2729:
2727:
2725:
2723:
2721:
2719:
2624:
2622:
2620:
2448:
1649:until corrective surgery can be performed (see
629:negative regulation of eosinophil extravasation
27:Protein-coding gene in the species Homo sapiens
9583:
2775:
2773:
2771:
2446:
2444:
2442:
2440:
2438:
2436:
2434:
2432:
2430:
2428:
2355:GRCm38: Ensembl release 89: ENSMUSG00000039942
2104:) but no follow-up studies have been recorded.
9560:
8016:
7217:
4298:
3532:IUPHAR Database of Receptors and Ion Channels
2238:is associated with an increased incidence of
1964:-receptor antagonist inhibits the growth and
684:cellular response to prostaglandin E stimulus
8:
8144:
4093:Fujino H, West KA, Regan JW (January 2002).
3191:Bioorganic & Medicinal Chemistry Letters
2270:, correlate with the expression levels of EP
2189:reaction involving the acute development of
2137:Grapiprant, a highly selective and potent EP
689:G protein-coupled receptor signaling pathway
674:negative regulation of inflammatory response
609:positive regulation of inflammatory response
2334:GRCh38: Ensembl release 89: ENSG00000171522
8610:
7458:
7277:
7259:
7224:
7210:
7202:
7106:
7088:
6899:
6875:
6441:
6423:
5759:
5146:
4791:
4352:
4343:
4325:
4305:
4291:
4283:
4273:United States National Library of Medicine
2157:(SNP) A/G variant rs10440635 close to the
729:
604:negative regulation of integrin activation
519:
316:
215:
112:
4175:
4110:
4029:
3994:
3959:
3820:
3780:
3770:
3669:
3612:
3380:
3370:
3281:
3113:
3060:
2977:
2936:
2895:
2851:
2751:
2656:
2646:
2600:
2567:Ichikawa A, Sugimoto Y, Tanaka S (2010).
2470:
4271:This article incorporates text from the
1995:stimulates the in vitro growth of human
1895:accompanied by poor cardiac function. EP
644:cellular response to mechanical stimulus
2321:
2277:The A/T SNP variant, rs4434423, in the
1434:activation of G proteins also activate
1350:or other of its agonists, it mobilizes
8615:
5455:Luteinizing hormone/choriogonadotropin
1130:rhodopsin-like receptors#Subfamily A14
29:
6459:Brain-specific angiogenesis inhibitor
3415:from the original on 19 February 2017
3236:from the original on 18 February 2017
1732:plaques by promoting the death (i.e.
280:
241:
236:
179:
138:
133:
7:
9238:Selective COX-2 inhibitors (coxibs):
4156:Clinical and Experimental Immunology
3745:Fedyk ER, Phipps RP (October 1996).
3605:10.1016/j.neurobiolaging.2014.12.029
2183:non-steroidal anti-inflammatory drug
1635:nonsteroidal anti-inflammatory drugs
1342:is classified as a relaxant type of
7347:Tooltip Prostaglandin D2 receptor 2
7290:Tooltip Prostaglandin D2 receptor 1
4099:The Journal of Biological Chemistry
3983:The Journal of Biological Chemistry
3658:The Journal of Biological Chemistry
2548:from the original on 2 January 2018
1736:) of plaque-bound pro-inflammatory
1647:Transposition of the great arteries
634:regulation of stress fiber assembly
537:G protein-coupled receptor activity
9209:AM-404 (N-arachidonoylaminophenol)
9027:Anthranilic acids (fenamic acids):
8679:Mesalazine (5-aminosalicylic acid)
7770:Tooltip Prostaglandin EP4 receptor
7655:Tooltip Prostaglandin EP3 receptor
7578:Tooltip Prostaglandin EP2 receptor
7471:Tooltip Prostaglandin EP1 receptor
3106:10.1016/j.neuroscience.2009.03.014
2040:antagonists significantly reduced
1831:Studies in mice found that the PGE
1629:in mice and, at least in lambs, EP
965:
944:
914:
893:
869:
850:
824:
805:
779:
760:
588:intracellular anatomical structure
498:
416:
354:
333:
25:
9699:γ-Linolenic acid (gamolenic acid)
9045:Meclofenamic acid (meclofenamate)
7454:Tooltip Prostaglandin E2 receptor
7273:Tooltip Prostaglandin D2 receptor
3500:from the original on 4 March 2017
3445:from the original on 4 March 2017
2979:10.1152/ajpheart.2001.280.5.H2342
2305:Prostaglandin E2 receptor 3 (EP3)
2300:Prostaglandin E2 receptor 2 (EP2)
2295:Prostaglandin E2 receptor 1 (EP1)
2100:clinical trial finished in 2009 (
1684:thereby promoting development of
1609:; at birth, however, levels of EP
1378:components which act to regulate
1277:, both PGs having high affinity (
557:prostaglandin E receptor activity
9754:Leukotriene signaling modulators
9546:Tooltip Prostaglandin F synthase
9527:Tooltip Prostaglandin E synthase
9486:Tooltip Prostaglandin D synthase
7928:Tooltip Prostaglandin F receptor
6808:Growth-hormone-releasing hormone
4168:10.1046/j.1365-2249.2002.01718.x
2925:Japanese Journal of Pharmacology
2782:European Journal of Pharmacology
2526:from the original on 2010-12-05.
264:
257:
251:
228:
163:
156:
150:
125:
9065:Talinflumic acid (talinflumate)
9055:Morniflumic acid (morniflumate)
9035:Floctafenic acid (floctafenate)
9018:Tiaprofenic acid (tiaprofenate)
6768:Corticotropin-releasing hormone
3471:from the original on 2018-05-06
2501:from the original on 2017-02-11
2414:from the original on 2016-02-26
2232:Genome-wide association studies
2141:antagonist, is approved by the
2023:receptors are expressed in the
1692:, a subset of pro-inflammatory
1416:corticotropin-releasing hormone
624:response to mechanical stimulus
542:prostaglandin receptor activity
9588:Tooltip Thromboxane A synthase
8639:Aspirin (acetylsalicylic acid)
7853:16,16-Dimethyl Prostaglandin E
5430:Gonadotropin-releasing hormone
4012:Desai S, Ashby B (July 2001).
3490:"No items found - Gene - NCBI"
3435:"No items found - Gene - NCBI"
3405:"No items found - Gene - NCBI"
2694:10.1152/physrev.1999.79.4.1193
2250:for the transcription factor,
2155:Single nucleotide polymorphism
1976:receptor antagonist as well EP
1968:of human prostate cancer cell
1853:basic fibroblast growth factor
1728:suppresses the development of
1656:To allow further studies of EP
1166:corpus cavernosum of the penis
649:response to lipopolysaccharide
573:integral component of membrane
482:More reference expression data
1:
9747:Receptor/signaling modulators
9569:Tooltip Prostacyclin synthase
9070:Tolfenamic acid (tolfenamate)
9040:Flufenamic acid (flufenamate)
9030:Etofenamic acid (etofenamate)
8086:Prostacyclin (prostaglandin I
8025:Tooltip Prostacyclin receptor
6848:Vasoactive intestinal peptide
5718:Thyrotropin-releasing hormone
4070:10.1016/S0006-2952(01)00742-0
4031:10.1016/S0014-5793(01)02640-0
3889:10.1016/S0198-8859(00)00131-2
3860:10.1016/S0006-2952(97)00011-7
3801:Journal of Molecular Medicine
3671:10.1016/S0021-9258(17)32654-6
1676:suppresses the production of
1605:keeps the ductus open in the
1144:for EP4 has been detected by
664:T-helper cell differentiation
249:
148:
8153:Tooltip Thromboxane receptor
3572:10.1016/0888-7543(95)80022-E
3022:10.1016/j.biochi.2014.08.010
2794:10.1016/j.ejphar.2016.12.004
2753:10.1016/j.drudis.2016.08.003
2635:Journal of Diabetes Research
2208:function, lower levels of EP
2143:Food and Drug Administration
1700:supports the development of
1547:heterologous desensitization
1521:Following its activation, EP
1390:to raise cellular levels of
1334:Mechanism of cell activation
9781:G protein-coupled receptors
9776:Genes on human chromosome 5
9219:Paracetamol (acetaminophen)
9050:Mefenamic acid (mefenamate)
8704:Salicylate (salicylic acid)
5633:Prolactin-releasing peptide
4318:G protein-coupled receptors
2826:Kalinski P (January 2012).
2542:www.guidetopharmacology.org
1913:Site-specific recombination
1905:ischemic reperfusion injury
1889:ischemic reperfusion injury
1849:Tumor necrosis factor alpha
1808:inflammatory bowel diseases
1720:inhibit antibody-producing
1382:pathways. In particular, Gα
1156:in pulmonary veins; kidney
9797:
8898:Bucloxic acid (blucloxate)
8816:Indometacin (indomethacin)
4254:10.1182/blood-2001-11-0017
3203:10.1016/j.bmcl.2017.01.067
2046:oxygen-induced retinopathy
2042:corneal neovascularization
1997:non-small cell lung cancer
1527:homologous desensitization
1126:G protein-coupled receptor
659:regulation of ossification
547:signal transducer activity
9738:
9060:Niflumic acid (niflumate)
8164:Carbocyclic thromboxane A
7105:
7087:
6898:
6874:
6440:
6422:
4342:
4324:
3524:"Prostanoid Receptors: EP
3359:Frontiers in Pharmacology
3319:10.1007/s10067-015-2956-4
2880:"Cyclooxygenase pathways"
2390:"Mouse PubMed Reference:"
2372:"Human PubMed Reference:"
1999:while an antagonist of EP
1426:, cellular survival, and
1042:
1037:
1033:
1026:
1010:
991:
972:
951:
940:
921:
900:
889:
876:
872:
857:
853:
844:
831:
827:
812:
808:
799:
786:
782:
767:
763:
754:
739:
732:
728:
712:
522:
518:
506:
501:
492:
479:
428:
419:
390:bronchial epithelial cell
366:
357:
327:
319:
315:
298:
285:
248:
227:
218:
214:
197:
184:
147:
124:
115:
111:
66:
63:
53:
46:
41:
37:
32:
9378:Menatetrenone (vitamin K
9201:Aminophenols (anilines):
6954:Calcium-sensing receptor
6823:Methuselah-like proteins
4196:Clinical Cancer Research
4058:Biochemical Pharmacology
3848:Biochemical Pharmacology
3772:10.1073/pnas.93.20.10978
3372:10.3389/fphar.2016.00316
2884:Acta Biochimica Polonica
2844:10.4049/jimmunol.1101029
1714:antigen-presenting cells
1643:Patent ductus arteriosus
1452:cellular differentiation
1424:cellular differentiation
9704:Dihomo-γ-linolenic acid
9101:Enolic acids (oxicams):
8644:Benorilate (benorylate)
5100:Sphingosine-1-phosphate
4988:Hydroxycarboxylic acids
2459:Pharmacological Reviews
2181:is associated with the
1919:method to inactivate EP
1541:can also desensitize EP
1312:cardiovascular diseases
1173:atherosclerotic plaques
1110:Prostaglandin receptors
997:Chr 5: 40.68 – 40.69 Mb
382:mucosa of sigmoid colon
9503:selenium tetrachloride
6981:Metabotropic glutamate
4112:10.1074/jbc.M109440200
3996:10.1074/jbc.M104036200
3952:10.1210/jcem.86.5.7442
3907:Molecular Pharmacology
3730:10.1006/geno.1996.0337
3701:10.1006/bbrc.1993.2470
3633:Molecular Pharmacology
2897:10.18388/abp.2014_1825
2279:5'-untranslated region
2163:Ankylosing spondylitis
2071:translational research
2065:Translational research
1925:dilated cardiomyopathy
1781:Gastrointestinal tract
1472:nuclear factor kappa B
1420:cellular proliferation
1344:prostaglandin receptor
1265:), which has one less
1212:cells of the eye; and
1071:prostaglandin receptor
1004:Chr 15: 5.24 – 5.27 Mb
452:mesenteric lymph nodes
444:atrioventricular valve
386:metanephric glomerulus
9172:Aminonicotinic acids:
5010:Lysophosphatidic acid
4314:Cell surface receptor
3919:10.1124/mol.58.6.1279
3593:Neurobiology of Aging
3307:Clinical Rheumatology
2832:Journal of Immunology
2682:Physiological Reviews
2472:10.1124/pr.110.003517
2060:Clinical significance
1901:myocardial infarction
1186:endothelium, corneal
1150:dorsal root ganglions
694:inflammatory response
619:ERK1 and ERK2 cascade
370:palpebral conjunctiva
282:15 A1|15 1.99 cM
243:Chromosome 15 (mouse)
8821:Indometacin farnesil
8674:Magnesium salicylate
8305:Pinane thromboxane A
8066:Iloprost (ciloprost)
7686:Iloprost (ciloprost)
7492:Iloprost (ciloprost)
6935:Vomeronasal receptor
5905:Vomeronasal receptor
3494:www.ncbi.nlm.nih.gov
3439:www.ncbi.nlm.nih.gov
3409:www.ncbi.nlm.nih.gov
3230:www.ncbi.nlm.nih.gov
3062:10.1096/fj.15-274597
2740:Drug Discovery Today
2648:10.1155/2016/1324347
2170:expression pattern.
1766:Dorsal root ganglion
1724:from proliferating;
1623:receptor antagonists
1545:by a process termed
1324:receptor antagonists
1164:of kidney arteries;
141:Chromosome 5 (human)
8649:Carbasalate calcium
6828:Parathyroid hormone
4788:signaling molecules
3763:1996PNAS...9310978F
3016:. 107 Pt A: 78–81.
2593:10.2183/pjab.86.848
2585:2010PJAB...86..848I
2310:Eicosanoid receptor
1893:cardiac hypertrophy
1891:but also stimulate
1764:suppresses sensory
1746:Alzheimer's disease
1664:deletion are used.
1304:Alzheimer's disease
679:signal transduction
440:conjunctival fornix
402:germinal epithelium
9511:selenium disulfide
9143:4-Aminoquinolines:
6977:Glutamate receptor
6362:Protease-activated
4275:, which is in the
3813:10.1007/BF00207510
2938:10.1254/jjp.83.279
2177:at -1254G>A in
2044:in rats caused by
1814:. Activation of EP
1812:ulcerative colitis
1702:Regulatory T cells
1593:). About 95% of EP
1318:Inhibiting ligands
1300:ulcerative colitis
1225:Activating ligands
834:ENSMUSG00000039942
597:Biological process
566:Cellular component
530:Molecular function
105:PTGER4 - orthologs
9763:
9762:
9679:
9678:
8714:Sodium salicylate
8684:Methyl salicylate
8607:
8592:
8591:
7913:
7912:
7439:
7438:
7256:
7199:
7198:
7195:
7194:
7191:
7190:
7083:
7082:
7079:
7078:
6870:
6869:
6866:
6865:
6418:
6417:
6414:
6413:
6410:
6409:
5751:
5750:
5138:
5137:
4781:
4780:
3160:10.1111/jvp.12380
1911:deficiency using
1619:receptor agonists
1583:ductus arteriosus
1573:Ductus arteriosus
1394:; cAMP activates
1146:northern blotting
1081:) encoded by the
1053:
1052:
1049:
1048:
1022:
1021:
987:
986:
962:
961:
936:
935:
911:
910:
885:
884:
866:
865:
840:
839:
821:
820:
795:
794:
776:
775:
724:
723:
514:
513:
510:
509:
488:
487:
475:
474:
413:
412:
311:
310:
210:
209:
16:(Redirected from
9788:
9714:Arachidonic acid
9589:
9585:
9570:
9566:
9547:
9543:
9528:
9524:
9487:
9483:
9310:Others/unsorted:
8885:Propionic acids:
8866:Sulindac sulfide
8631:Salicylic acids:
8622:
8617:
8611:
8601:
8154:
8150:
8026:
8022:
7929:
7925:
7771:
7767:
7656:
7652:
7579:
7575:
7472:
7468:
7459:
7455:
7451:
7348:
7344:
7291:
7287:
7278:
7274:
7270:
7260:
7250:
7226:
7219:
7212:
7203:
7107:
7089:
6900:
6876:
6442:
6424:
5760:
5147:
5045:Lysophospholipid
4792:
4353:
4348:Neurotransmitter
4344:
4326:
4307:
4300:
4293:
4284:
4265:
4232:
4217:Molecular Vision
4211:
4189:
4179:
4146:
4124:
4114:
4089:
4051:
4033:
4008:
3998:
3989:(34): 31720–31.
3973:
3963:
3930:
3900:
3877:Human Immunology
3871:
3842:
3824:
3794:
3784:
3774:
3757:(20): 10978–83.
3741:
3712:
3683:
3673:
3648:
3626:
3616:
3583:
3546:
3544:
3543:
3510:
3509:
3507:
3505:
3486:
3480:
3479:
3477:
3476:
3461:
3455:
3454:
3452:
3450:
3431:
3425:
3424:
3422:
3420:
3401:
3395:
3394:
3384:
3374:
3350:
3339:
3338:
3302:
3296:
3295:
3285:
3252:
3246:
3245:
3243:
3241:
3221:
3215:
3214:
3197:(5): 1186–1192.
3186:
3180:
3179:
3142:
3136:
3135:
3117:
3089:
3083:
3082:
3064:
3040:
3034:
3033:
3009:
3000:
2999:
2981:
2957:
2951:
2950:
2940:
2916:
2910:
2909:
2899:
2875:
2866:
2865:
2855:
2823:
2814:
2813:
2777:
2766:
2765:
2755:
2731:
2714:
2713:
2677:
2671:
2670:
2660:
2650:
2626:
2615:
2614:
2604:
2564:
2558:
2557:
2555:
2553:
2534:
2528:
2527:
2516:
2510:
2509:
2507:
2506:
2491:
2485:
2484:
2474:
2450:
2423:
2422:
2420:
2419:
2404:
2398:
2397:
2386:
2380:
2379:
2368:
2362:
2352:
2341:
2331:
2187:hypersensitivity
2167:Vertebral column
2095:
2094:
2093:
2081:The selective EP
2073:studies using EP
1939:Lipid metabolism
1839:pathway induces
1752:increases local
1672:Activation of EP
1589:(-/-) mice (see
1539:protein kinase C
1356:Gs alpha subunit
1259:Prostaglandin E1
1192:trabecular cells
1075:prostaglandin E2
1035:
1034:
1006:
999:
982:
966:
957:
945:
941:RefSeq (protein)
931:
915:
906:
894:
870:
851:
825:
806:
780:
761:
730:
669:bone development
520:
499:
484:
424:
422:Top expressed in
417:
362:
360:Top expressed in
355:
334:
317:
307:
294:
283:
268:
261:
255:
244:
232:
216:
206:
193:
182:
167:
160:
154:
143:
129:
113:
107:
58:
51:
30:
21:
9796:
9795:
9791:
9790:
9789:
9787:
9786:
9785:
9766:
9765:
9764:
9759:
9734:
9730:
9727:Prostaglandin H
9722:
9719:Prostaglandin G
9675:
9587:
9577:
9575:Tranylcypromine
9568:
9564:
9554:
9545:
9535:
9526:
9516:
9507:sodium selenite
9485:
9481:
9471:
9417:Rosmarinic acid
9381:
9189:Sulfonanilides:
9092:Oxyphenbutazone
8618:
8600:
8588:
8367:
8308:
8180:
8167:
8152:
8148:
8138:
8098:
8095:Prostaglandin E
8090:, epoprostenol)
8089:
8024:
8020:
8010:
7985:
7982:Prostaglandin F
7977:
7974:Prostaglandin D
7927:
7923:
7909:
7894:
7891:Prostaglandin F
7856:
7838:
7803:
7800:Prostaglandin E
7794:
7791:Prostaglandin E
7769:
7766:
7756:
7737:Ricinoleic acid
7726:
7723:Prostaglandin E
7717:
7714:Prostaglandin E
7709:
7706:Prostaglandin D
7654:
7651:
7641:
7611:
7608:Prostaglandin E
7602:
7599:Prostaglandin E
7577:
7574:
7564:
7524:
7521:Prostaglandin E
7515:
7512:Prostaglandin E
7470:
7467:
7453:
7449:
7435:
7366:
7363:Prostaglandin D
7346:
7343:
7333:
7304:
7301:Prostaglandin D
7289:
7286:
7272:
7268:
7249:
7241:
7230:
7200:
7187:
7171:
7101:
7075:
6962:
6940:
6894:
6862:
6744:
6621:
6436:
6406:
6293:
5910:
5747:
5353:Cholecystokinin
5257:
5134:
4963:Free fatty acid
4903:
4787:
4786:Metabolites and
4777:
4617:
4522:
4419:
4338:
4320:
4311:
4268:
4235:
4214:
4192:
4149:
4131:Cancer Research
4127:
4092:
4064:(8): 997–1012.
4054:
4024:(2–3): 156–60.
4011:
3976:
3933:
3903:
3874:
3845:
3797:
3744:
3715:
3686:
3664:(16): 11873–7.
3651:
3629:
3586:
3557:
3553:
3551:Further reading
3541:
3539:
3527:
3522:
3519:
3514:
3513:
3503:
3501:
3488:
3487:
3483:
3474:
3472:
3463:
3462:
3458:
3448:
3446:
3433:
3432:
3428:
3418:
3416:
3403:
3402:
3398:
3352:
3351:
3342:
3304:
3303:
3299:
3262:Nature Genetics
3254:
3253:
3249:
3239:
3237:
3223:
3222:
3218:
3188:
3187:
3183:
3144:
3143:
3139:
3091:
3090:
3086:
3055:(12): 4924–36.
3042:
3041:
3037:
3011:
3010:
3003:
2959:
2958:
2954:
2918:
2917:
2913:
2877:
2876:
2869:
2825:
2824:
2817:
2779:
2778:
2769:
2733:
2732:
2717:
2688:(4): 1193–226.
2679:
2678:
2674:
2628:
2627:
2618:
2566:
2565:
2561:
2551:
2549:
2536:
2535:
2531:
2518:
2517:
2513:
2504:
2502:
2493:
2492:
2488:
2452:
2451:
2426:
2417:
2415:
2406:
2405:
2401:
2388:
2387:
2383:
2370:
2369:
2365:
2353:
2344:
2332:
2323:
2318:
2291:
2273:
2240:Crohn's disease
2215:
2211:
2152:
2150:Genomic Studies
2140:
2129:
2125:
2110:
2092:
2089:
2088:
2087:
2086:
2084:
2076:
2067:
2062:
2055:
2051:
2039:
2034:
2022:
2017:
2010:
2006:
2002:
1994:
1986:
1979:
1975:
1963:
1959:
1954:
1946:
1941:
1934:
1930:
1922:
1917:Cre recombinase
1910:
1898:
1886:
1881:
1874:
1866:
1862:
1858:
1838:
1834:
1829:
1817:
1805:
1801:
1793:
1789:
1784:
1730:Atherosclerosis
1710:Dendritic cells
1675:
1670:
1663:
1659:
1637:, particularly
1632:
1628:
1616:
1612:
1604:
1600:
1596:
1588:
1580:
1575:
1568:
1564:
1560:
1555:
1544:
1536:
1532:
1524:
1512:
1505:
1498:
1491:
1485:
1481:
1476:NF-κB#Structure
1461:
1433:
1385:
1377:
1373:
1369:
1361:
1354:containing the
1349:
1341:
1336:
1329:
1320:
1296:
1292:
1288:
1276:
1272:
1264:
1240:
1236:
1227:
1222:
1177:Abdominal aorta
1154:immunochemistry
1138:
1122:
1115:
1103:
1099:
1095:
1091:
1080:
1067:
1059:
1056:Prostaglandin E
1044:View/Edit Mouse
1039:View/Edit Human
1002:
995:
992:Location (UCSC)
978:
974:
953:
927:
923:
902:
815:ENSG00000171522
708:
654:immune response
592:
583:plasma membrane
561:
552:protein binding
480:
471:
466:
462:
458:
454:
450:
446:
442:
438:
434:
432:renal corpuscle
420:
409:
406:parietal pleura
404:
400:
396:
394:visceral pleura
392:
388:
384:
380:
376:
372:
358:
302:
289:
281:
271:
270:
269:
262:
242:
219:Gene location (
201:
188:
180:
170:
169:
168:
161:
139:
116:Gene location (
67:
54:
47:
28:
23:
22:
15:
12:
11:
5:
9794:
9792:
9784:
9783:
9778:
9768:
9767:
9761:
9760:
9758:
9757:
9750:
9743:
9739:
9736:
9735:
9733:
9732:
9728:
9724:
9720:
9716:
9711:
9709:Diacylglycerol
9706:
9701:
9696:
9687:
9685:
9681:
9680:
9677:
9676:
9674:
9673:
9668:
9663:
9658:
9653:
9648:
9643:
9638:
9633:
9628:
9623:
9618:
9613:
9608:
9603:
9598:
9592:
9590:
9579:
9578:
9573:
9571:
9562:
9556:
9555:
9550:
9548:
9537:
9536:
9531:
9529:
9518:
9517:
9515:
9514:
9496:
9490:
9488:
9479:
9473:
9472:
9470:
9469:
9464:
9459:
9454:
9449:
9444:
9439:
9434:
9429:
9424:
9419:
9414:
9409:
9404:
9399:
9394:
9389:
9384:
9379:
9375:
9370:
9365:
9360:
9355:
9350:
9345:
9340:
9335:
9330:
9325:
9320:
9315:
9303:
9298:
9293:
9288:
9283:
9278:
9273:
9268:
9263:
9258:
9253:
9248:
9243:
9231:
9226:
9221:
9216:
9211:
9206:
9194:
9182:
9177:
9165:
9153:
9148:
9136:
9131:
9126:
9121:
9116:
9111:
9106:
9097:Phenylbutazone
9094:
9089:
9084:
9079:
9067:
9062:
9057:
9052:
9047:
9042:
9037:
9032:
9020:
9015:
9010:
9005:
9000:
8995:
8990:
8985:
8980:
8975:
8970:
8965:
8960:
8955:
8950:
8945:
8940:
8935:
8930:
8925:
8920:
8915:
8910:
8905:
8900:
8895:
8890:
8878:
8873:
8868:
8863:
8858:
8853:
8848:
8843:
8838:
8833:
8828:
8823:
8818:
8813:
8808:
8803:
8798:
8793:
8788:
8783:
8778:
8773:
8768:
8763:
8758:
8753:
8748:
8743:
8738:
8733:
8728:
8716:
8711:
8706:
8701:
8696:
8691:
8686:
8681:
8676:
8671:
8666:
8661:
8656:
8651:
8646:
8641:
8636:
8627:
8625:
8608:
8594:
8593:
8590:
8589:
8587:
8586:
8581:
8576:
8571:
8566:
8561:
8556:
8551:
8546:
8541:
8536:
8531:
8526:
8521:
8516:
8511:
8506:
8501:
8496:
8491:
8486:
8481:
8476:
8471:
8466:
8461:
8456:
8451:
8446:
8441:
8436:
8431:
8426:
8421:
8416:
8411:
8406:
8401:
8396:
8391:
8386:
8381:
8375:
8373:
8369:
8368:
8366:
8365:
8360:
8355:
8350:
8345:
8340:
8335:
8330:
8325:
8320:
8315:
8310:
8306:
8302:
8297:
8292:
8287:
8282:
8277:
8272:
8267:
8262:
8257:
8252:
8247:
8242:
8237:
8232:
8227:
8222:
8217:
8212:
8207:
8202:
8193:
8192:
8187:
8182:
8178:
8174:
8169:
8165:
8157:
8155:
8146:
8140:
8139:
8137:
8136:
8127:
8126:
8121:
8116:
8111:
8106:
8101:
8096:
8092:
8087:
8083:
8078:
8073:
8071:Isocarbacyclin
8068:
8063:
8058:
8053:
8048:
8043:
8038:
8029:
8027:
8018:
8012:
8011:
8009:
8008:
8003:
7998:
7993:
7988:
7983:
7979:
7975:
7971:
7966:
7961:
7956:
7951:
7946:
7941:
7932:
7930:
7921:
7915:
7914:
7911:
7910:
7908:
7907:
7902:
7897:
7892:
7888:
7883:
7878:
7873:
7868:
7863:
7858:
7854:
7846:
7844:
7840:
7839:
7837:
7836:
7831:
7826:
7821:
7812:
7811:
7806:
7804:(dinoprostone)
7801:
7797:
7792:
7788:
7783:
7774:
7772:
7764:
7758:
7757:
7755:
7754:
7745:
7744:
7739:
7734:
7729:
7727:(dinoprostone)
7724:
7720:
7715:
7711:
7707:
7703:
7698:
7693:
7691:Isocarbacyclin
7688:
7683:
7678:
7673:
7668:
7659:
7657:
7649:
7643:
7642:
7640:
7639:
7634:
7629:
7620:
7619:
7614:
7612:(dinoprostone)
7609:
7605:
7600:
7596:
7591:
7582:
7580:
7572:
7566:
7565:
7563:
7562:
7557:
7552:
7547:
7542:
7533:
7532:
7527:
7525:(dinoprostone)
7522:
7518:
7513:
7509:
7504:
7499:
7494:
7489:
7484:
7475:
7473:
7465:
7456:
7447:
7441:
7440:
7437:
7436:
7434:
7433:
7428:
7423:
7418:
7413:
7408:
7403:
7398:
7393:
7388:
7383:
7378:
7369:
7368:
7364:
7360:
7351:
7349:
7341:
7335:
7334:
7332:
7331:
7326:
7321:
7312:
7311:
7306:
7302:
7294:
7292:
7284:
7275:
7266:
7257:
7243:
7242:
7231:
7229:
7228:
7221:
7214:
7206:
7197:
7196:
7193:
7192:
7189:
7188:
7186:
7185:
7179:
7177:
7173:
7172:
7170:
7169:
7163:
7158:
7153:
7148:
7143:
7138:
7133:
7128:
7123:
7113:
7111:
7103:
7102:
7092:
7085:
7084:
7081:
7080:
7077:
7076:
7074:
7073:
7067:
7062:
7057:
7048:
7042:
7037:
7028:
7023:
7017:
7012:
7007:
7002:
6997:
6992:
6987:
6974:
6968:
6960:
6956:
6950:
6948:
6942:
6941:
6939:
6938:
6932:
6931:
6930:
6925:
6920:
6909:
6907:
6896:
6895:
6879:
6872:
6871:
6868:
6867:
6864:
6863:
6861:
6860:
6854:
6845:
6840:
6834:
6825:
6820:
6815:
6810:
6805:
6799:
6794:
6789:
6780:
6774:
6765:
6760:
6754:
6752:
6746:
6745:
6743:
6742:
6736:
6731:
6726:
6721:
6716:
6711:
6706:
6701:
6696:
6691:
6686:
6681:
6676:
6671:
6666:
6661:
6656:
6651:
6646:
6641:
6631:
6629:
6623:
6622:
6620:
6619:
6618:
6617:
6612:
6611:
6610:
6605:
6600:
6585:
6584:
6583:
6578:
6573:
6568:
6563:
6558:
6553:
6543:
6542:
6541:
6536:
6535:
6534:
6529:
6524:
6509:
6508:
6507:
6506:
6505:
6500:
6495:
6480:
6479:
6478:
6477:
6476:
6471:
6466:
6450:
6448:
6438:
6437:
6427:
6420:
6419:
6416:
6415:
6412:
6411:
6408:
6407:
6405:
6404:
6398:
6393:
6384:
6378:
6373:
6368:
6359:
6353:
6348:
6343:
6338:
6333:
6328:
6323:
6314:
6309:
6307:Adrenomedullin
6303:
6301:
6295:
6294:
6292:
6291:
6285:
6280:
6275:
6270:
6265:
6260:
6255:
6250:
6245:
6240:
6235:
6230:
6225:
6220:
6215:
6210:
6205:
6200:
6195:
6190:
6185:
6180:
6175:
6170:
6165:
6160:
6155:
6150:
6145:
6140:
6135:
6130:
6125:
6120:
6115:
6110:
6105:
6100:
6095:
6090:
6085:
6080:
6075:
6070:
6065:
6060:
6055:
6050:
6045:
6040:
6035:
6030:
6025:
6020:
6015:
6010:
6005:
6000:
5995:
5990:
5985:
5980:
5975:
5970:
5965:
5960:
5955:
5950:
5945:
5940:
5935:
5930:
5920:
5918:
5912:
5911:
5909:
5908:
5902:
5901:
5900:
5895:
5890:
5885:
5880:
5875:
5870:
5865:
5860:
5855:
5850:
5845:
5840:
5835:
5830:
5825:
5820:
5815:
5810:
5805:
5800:
5795:
5790:
5785:
5780:
5769:
5767:
5757:
5753:
5752:
5749:
5748:
5746:
5745:
5739:
5734:
5725:
5720:
5715:
5710:
5704:
5699:
5690:
5684:
5679:
5674:
5669:
5660:
5654:
5649:
5644:
5635:
5630:
5624:
5615:
5610:
5604:
5595:
5581:
5576:
5571:
5562:
5557:
5551:
5542:
5536:
5531:
5526:
5521:
5512:
5506:
5501:
5496:
5491:
5486:
5481:
5476:
5471:
5466:
5457:
5452:
5447:
5442:
5436:
5427:
5421:
5416:
5407:
5402:
5396:
5391:
5385:Formyl peptide
5382:
5381:
5380:
5375:
5365:
5359:
5350:
5345:
5344:
5343:
5337:
5328:
5322:
5317:
5307:
5302:
5296:
5287:
5281:
5275:
5265:
5263:
5259:
5258:
5256:
5255:
5249:
5240:
5234:
5225:
5216:
5210:
5205:
5200:
5191:
5186:
5180:
5171:
5165:
5155:
5153:
5144:
5140:
5139:
5136:
5135:
5133:
5132:
5127:
5121:
5116:
5111:
5106:
5097:
5092:
5087:
5081:
5076:
5071:
5066:
5061:
5056:
5051:
5042:
5036:
5031:
5026:
5021:
5016:
5007:
5006:
5005:
5000:
4995:
4985:
4979:
4974:
4969:
4960:
4955:
4950:
4944:
4939:
4926:
4917:
4911:
4909:
4905:
4904:
4902:
4901:
4896:
4891:
4890:
4889:
4880:
4875:
4870:
4857:
4843:
4838:
4833:
4832:
4831:
4826:
4816:
4810:
4800:
4798:
4789:
4783:
4782:
4779:
4778:
4776:
4775:
4769:
4764:
4759:
4754:
4749:
4740:
4734:
4729:
4720:
4719:
4718:
4713:
4708:
4703:
4693:
4688:
4687:
4686:
4681:
4676:
4671:
4666:
4656:
4650:
4645:
4640:
4635:
4625:
4623:
4619:
4618:
4616:
4615:
4609:
4604:
4599:
4590:
4584:
4579:
4570:
4564:
4559:
4554:
4549:
4532:
4530:
4524:
4523:
4521:
4520:
4514:
4509:
4504:
4499:
4494:
4489:
4484:
4479:
4474:
4469:
4464:
4455:
4449:
4444:
4439:
4429:
4427:
4421:
4420:
4418:
4417:
4412:
4407:
4402:
4396:
4391:
4382:
4376:
4371:
4361:
4359:
4350:
4340:
4339:
4329:
4322:
4321:
4312:
4310:
4309:
4302:
4295:
4287:
4267:
4266:
4248:(4): 1354–61.
4233:
4212:
4202:(4): 1157–67.
4194:progression".
4190:
4147:
4125:
4090:
4052:
4009:
3974:
3931:
3913:(6): 1279–86.
3901:
3872:
3854:(9): 1249–55.
3843:
3795:
3742:
3713:
3684:
3649:
3627:
3599:(3): 1439–50.
3584:
3554:
3552:
3549:
3548:
3547:
3525:
3518:
3517:External links
3515:
3512:
3511:
3481:
3456:
3426:
3396:
3340:
3297:
3274:10.1038/ng.873
3247:
3216:
3181:
3154:(5): 468–475.
3137:
3084:
3035:
3001:
2972:(5): H2342-9.
2952:
2911:
2867:
2815:
2767:
2715:
2672:
2616:
2559:
2529:
2511:
2486:
2465:(3): 471–538.
2424:
2399:
2381:
2363:
2342:
2320:
2319:
2317:
2314:
2313:
2312:
2307:
2302:
2297:
2290:
2287:
2271:
2213:
2209:
2151:
2148:
2147:
2146:
2138:
2135:
2127:
2123:
2120:
2108:
2105:
2090:
2082:
2074:
2066:
2063:
2061:
2058:
2053:
2049:
2037:
2036:A selective EP
2033:
2030:
2020:
2016:
2013:
2008:
2004:
2000:
1992:
1984:
1981:Gene knockdown
1977:
1973:
1961:
1957:
1953:
1950:
1948:deficiencies.
1944:
1940:
1937:
1932:
1928:
1920:
1908:
1896:
1884:
1880:
1877:
1872:
1864:
1860:
1856:
1836:
1832:
1828:
1825:
1815:
1803:
1799:
1791:
1787:
1783:
1778:
1694:T helper cells
1680:and increases
1673:
1669:
1666:
1661:
1657:
1630:
1626:
1614:
1610:
1602:
1598:
1594:
1591:Knockout mouse
1586:
1578:
1574:
1571:
1566:
1562:
1558:
1554:
1551:
1542:
1534:
1530:
1522:
1510:
1503:
1496:
1489:
1483:
1479:
1459:
1431:
1418:that regulate
1388:adenyl cyclase
1383:
1380:cell signaling
1375:
1371:
1367:
1364:G beta-gammaes
1359:
1347:
1339:
1335:
1332:
1327:
1319:
1316:
1310:, and certain
1294:
1293:but unlike PGE
1290:
1286:
1274:
1270:
1262:
1238:
1234:
1226:
1223:
1221:
1218:
1170:carotid artery
1137:
1134:
1121:
1118:
1113:
1101:
1097:
1093:
1089:
1078:
1065:
1057:
1051:
1050:
1047:
1046:
1041:
1031:
1030:
1024:
1023:
1020:
1019:
1017:
1015:
1008:
1007:
1000:
993:
989:
988:
985:
984:
970:
969:
963:
960:
959:
949:
948:
942:
938:
937:
934:
933:
919:
918:
912:
909:
908:
898:
897:
891:
887:
886:
883:
882:
874:
873:
867:
864:
863:
855:
854:
848:
842:
841:
838:
837:
829:
828:
822:
819:
818:
810:
809:
803:
797:
796:
793:
792:
784:
783:
777:
774:
773:
765:
764:
758:
752:
751:
746:
741:
737:
736:
726:
725:
722:
721:
710:
709:
707:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
621:
616:
611:
606:
600:
598:
594:
593:
591:
590:
585:
580:
575:
569:
567:
563:
562:
560:
559:
554:
549:
544:
539:
533:
531:
527:
526:
516:
515:
512:
511:
508:
507:
504:
503:
496:
490:
489:
486:
485:
477:
476:
473:
472:
470:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
426:
425:
414:
411:
410:
408:
407:
403:
399:
398:synovial joint
395:
391:
387:
383:
379:
375:
374:jejunal mucosa
371:
367:
364:
363:
351:
350:
342:
331:
325:
324:
321:RNA expression
313:
312:
309:
308:
300:
296:
295:
287:
284:
279:
273:
272:
263:
256:
250:
246:
245:
240:
234:
233:
225:
224:
212:
211:
208:
207:
199:
195:
194:
186:
183:
178:
172:
171:
162:
155:
149:
145:
144:
137:
131:
130:
122:
121:
109:
108:
65:
61:
60:
52:
44:
43:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
9793:
9782:
9779:
9777:
9774:
9773:
9771:
9756:
9755:
9751:
9749:
9748:
9744:
9741:
9740:
9737:
9731:
9725:
9723:
9717:
9715:
9712:
9710:
9707:
9705:
9702:
9700:
9697:
9695:
9694:Linoleic acid
9692:
9689:
9688:
9686:
9682:
9672:
9669:
9667:
9664:
9662:
9659:
9657:
9654:
9652:
9649:
9647:
9644:
9642:
9639:
9637:
9634:
9632:
9629:
9627:
9624:
9622:
9619:
9617:
9614:
9612:
9609:
9607:
9604:
9602:
9599:
9597:
9594:
9593:
9591:
9586:
9580:
9576:
9572:
9567:
9557:
9553:
9549:
9544:
9538:
9534:
9530:
9525:
9519:
9512:
9508:
9504:
9500:
9497:
9495:
9492:
9491:
9489:
9484:
9474:
9468:
9465:
9463:
9460:
9458:
9455:
9453:
9450:
9448:
9445:
9443:
9440:
9438:
9435:
9433:
9430:
9428:
9425:
9423:
9420:
9418:
9415:
9413:
9410:
9408:
9405:
9403:
9400:
9398:
9395:
9393:
9390:
9388:
9385:
9383:
9376:
9374:
9371:
9369:
9366:
9364:
9361:
9359:
9356:
9354:
9351:
9349:
9346:
9344:
9341:
9339:
9336:
9334:
9331:
9329:
9326:
9324:
9321:
9319:
9316:
9314:
9311:
9307:
9304:
9302:
9299:
9297:
9294:
9292:
9289:
9287:
9284:
9282:
9279:
9277:
9274:
9272:
9269:
9267:
9264:
9262:
9259:
9257:
9254:
9252:
9249:
9247:
9244:
9242:
9239:
9235:
9232:
9230:
9227:
9225:
9222:
9220:
9217:
9215:
9212:
9210:
9207:
9205:
9202:
9198:
9195:
9193:
9190:
9186:
9183:
9181:
9178:
9176:
9173:
9169:
9166:
9164:
9163:Fluproquazone
9161:
9160:Quinazolines:
9157:
9154:
9152:
9149:
9147:
9144:
9140:
9137:
9135:
9132:
9130:
9127:
9125:
9122:
9120:
9117:
9115:
9112:
9110:
9107:
9105:
9102:
9098:
9095:
9093:
9090:
9088:
9085:
9083:
9080:
9078:
9075:
9071:
9068:
9066:
9063:
9061:
9058:
9056:
9053:
9051:
9048:
9046:
9043:
9041:
9038:
9036:
9033:
9031:
9028:
9024:
9021:
9019:
9016:
9014:
9011:
9009:
9006:
9004:
9001:
8999:
8996:
8994:
8991:
8989:
8986:
8984:
8981:
8979:
8976:
8974:
8971:
8969:
8966:
8964:
8961:
8959:
8956:
8954:
8951:
8949:
8946:
8944:
8941:
8939:
8938:Flunoxaprofen
8936:
8934:
8931:
8929:
8926:
8924:
8923:Dexketoprofen
8921:
8919:
8918:Dexindoprofen
8916:
8914:
8911:
8909:
8906:
8904:
8901:
8899:
8896:
8894:
8891:
8889:
8886:
8882:
8879:
8877:
8874:
8872:
8869:
8867:
8864:
8862:
8859:
8857:
8856:Proglumetacin
8854:
8852:
8849:
8847:
8844:
8842:
8839:
8837:
8834:
8832:
8829:
8827:
8824:
8822:
8819:
8817:
8814:
8812:
8809:
8807:
8804:
8802:
8799:
8797:
8794:
8792:
8789:
8787:
8786:Difenpiramide
8784:
8782:
8779:
8777:
8774:
8772:
8769:
8767:
8764:
8762:
8759:
8757:
8754:
8752:
8749:
8747:
8744:
8742:
8739:
8737:
8734:
8732:
8729:
8727:
8724:
8723:Acetic acids:
8720:
8717:
8715:
8712:
8710:
8707:
8705:
8702:
8700:
8697:
8695:
8692:
8690:
8687:
8685:
8682:
8680:
8677:
8675:
8672:
8670:
8667:
8665:
8662:
8660:
8657:
8655:
8652:
8650:
8647:
8645:
8642:
8640:
8637:
8635:
8632:
8629:
8628:
8626:
8624:
8612:
8609:
8605:
8599:
8595:
8585:
8582:
8580:
8577:
8575:
8572:
8570:
8567:
8565:
8562:
8560:
8557:
8555:
8552:
8550:
8547:
8545:
8542:
8540:
8537:
8535:
8532:
8530:
8527:
8525:
8522:
8520:
8517:
8515:
8512:
8510:
8507:
8505:
8502:
8500:
8497:
8495:
8492:
8490:
8487:
8485:
8482:
8480:
8477:
8475:
8472:
8470:
8467:
8465:
8462:
8460:
8457:
8455:
8454:Fenprostalene
8452:
8450:
8447:
8445:
8442:
8440:
8437:
8435:
8432:
8430:
8427:
8425:
8422:
8420:
8417:
8415:
8412:
8410:
8407:
8405:
8404:Delprostenate
8402:
8400:
8397:
8395:
8392:
8390:
8387:
8385:
8382:
8380:
8377:
8376:
8374:
8370:
8364:
8361:
8359:
8356:
8354:
8351:
8349:
8346:
8344:
8341:
8339:
8336:
8334:
8331:
8329:
8326:
8324:
8321:
8319:
8316:
8314:
8311:
8309:
8303:
8301:
8298:
8296:
8293:
8291:
8288:
8286:
8283:
8281:
8278:
8276:
8273:
8271:
8268:
8266:
8263:
8261:
8258:
8256:
8253:
8251:
8248:
8246:
8243:
8241:
8238:
8236:
8233:
8231:
8228:
8226:
8223:
8221:
8218:
8216:
8213:
8211:
8208:
8206:
8203:
8201:
8198:
8195:
8194:
8191:
8188:
8186:
8183:
8181:
8177:Thromboxane A
8175:
8173:
8170:
8168:
8162:
8159:
8158:
8156:
8151:
8141:
8135:
8132:
8129:
8128:
8125:
8122:
8120:
8117:
8115:
8112:
8110:
8107:
8105:
8102:
8100:
8099:(alprostadil)
8093:
8091:
8084:
8082:
8079:
8077:
8074:
8072:
8069:
8067:
8064:
8062:
8059:
8057:
8054:
8052:
8049:
8047:
8044:
8042:
8039:
8037:
8034:
8031:
8030:
8028:
8023:
8013:
8007:
8004:
8002:
7999:
7997:
7994:
7992:
7989:
7987:
7980:
7978:
7972:
7970:
7967:
7965:
7962:
7960:
7957:
7955:
7952:
7950:
7947:
7945:
7942:
7940:
7937:
7934:
7933:
7931:
7926:
7916:
7906:
7903:
7901:
7898:
7896:
7889:
7887:
7884:
7882:
7879:
7877:
7874:
7872:
7869:
7867:
7864:
7862:
7859:
7857:
7851:
7848:
7847:
7845:
7841:
7835:
7832:
7830:
7827:
7825:
7822:
7820:
7817:
7814:
7813:
7810:
7807:
7805:
7798:
7796:
7795:(alprostadil)
7789:
7787:
7784:
7782:
7779:
7776:
7775:
7773:
7768:
7759:
7753:
7750:
7747:
7746:
7743:
7740:
7738:
7735:
7733:
7730:
7728:
7721:
7719:
7718:(alprostadil)
7712:
7710:
7704:
7702:
7699:
7697:
7694:
7692:
7689:
7687:
7684:
7682:
7679:
7677:
7674:
7672:
7669:
7667:
7664:
7661:
7660:
7658:
7653:
7644:
7638:
7635:
7633:
7630:
7628:
7625:
7622:
7621:
7618:
7615:
7613:
7606:
7604:
7603:(alprostadil)
7597:
7595:
7592:
7590:
7587:
7584:
7583:
7581:
7576:
7567:
7561:
7558:
7556:
7553:
7551:
7548:
7546:
7543:
7541:
7538:
7535:
7534:
7531:
7528:
7526:
7519:
7517:
7516:(alprostadil)
7510:
7508:
7505:
7503:
7500:
7498:
7495:
7493:
7490:
7488:
7485:
7483:
7480:
7477:
7476:
7474:
7469:
7460:
7457:
7452:
7442:
7432:
7429:
7427:
7424:
7422:
7419:
7417:
7414:
7412:
7409:
7407:
7404:
7402:
7399:
7397:
7394:
7392:
7389:
7387:
7384:
7382:
7379:
7377:
7374:
7371:
7370:
7367:
7361:
7359:
7356:
7353:
7352:
7350:
7345:
7336:
7330:
7327:
7325:
7322:
7320:
7317:
7314:
7313:
7310:
7307:
7305:
7299:
7296:
7295:
7293:
7288:
7279:
7276:
7271:
7261:
7258:
7254:
7248:
7244:
7240:
7237:
7234:
7227:
7222:
7220:
7215:
7213:
7208:
7207:
7204:
7184:
7181:
7180:
7178:
7174:
7167:
7164:
7162:
7159:
7157:
7154:
7152:
7149:
7147:
7144:
7142:
7139:
7137:
7134:
7132:
7129:
7127:
7124:
7122:
7118:
7115:
7114:
7112:
7108:
7104:
7100:
7096:
7090:
7086:
7071:
7068:
7066:
7063:
7061:
7058:
7056:
7052:
7049:
7046:
7043:
7041:
7038:
7036:
7032:
7029:
7027:
7024:
7021:
7018:
7016:
7013:
7011:
7008:
7006:
7003:
7001:
6998:
6996:
6993:
6991:
6988:
6986:
6982:
6978:
6975:
6972:
6969:
6967:
6963:
6957:
6955:
6952:
6951:
6949:
6947:
6943:
6936:
6933:
6929:
6926:
6924:
6921:
6919:
6916:
6915:
6914:
6911:
6910:
6908:
6905:
6901:
6897:
6893:
6889:
6886:
6882:
6877:
6873:
6858:
6855:
6853:
6849:
6846:
6844:
6841:
6838:
6835:
6833:
6829:
6826:
6824:
6821:
6819:
6816:
6814:
6811:
6809:
6806:
6803:
6800:
6798:
6795:
6793:
6790:
6788:
6784:
6781:
6778:
6775:
6773:
6769:
6766:
6764:
6761:
6759:
6756:
6755:
6753:
6751:
6747:
6740:
6737:
6735:
6732:
6730:
6727:
6725:
6722:
6720:
6717:
6715:
6712:
6710:
6707:
6705:
6702:
6700:
6697:
6695:
6692:
6690:
6687:
6685:
6682:
6680:
6677:
6675:
6672:
6670:
6667:
6665:
6662:
6660:
6657:
6655:
6652:
6650:
6647:
6645:
6642:
6640:
6636:
6633:
6632:
6630:
6628:
6624:
6616:
6613:
6609:
6606:
6604:
6601:
6599:
6596:
6595:
6594:
6591:
6590:
6589:
6586:
6582:
6579:
6577:
6574:
6572:
6569:
6567:
6564:
6562:
6559:
6557:
6554:
6552:
6549:
6548:
6547:
6544:
6540:
6537:
6533:
6530:
6528:
6525:
6523:
6520:
6519:
6518:
6515:
6514:
6513:
6510:
6504:
6501:
6499:
6496:
6494:
6491:
6490:
6489:
6486:
6485:
6484:
6481:
6475:
6472:
6470:
6467:
6465:
6462:
6461:
6460:
6457:
6456:
6455:
6452:
6451:
6449:
6447:
6443:
6439:
6434:
6430:
6425:
6421:
6402:
6399:
6397:
6394:
6392:
6388:
6385:
6382:
6379:
6377:
6374:
6372:
6369:
6367:
6363:
6360:
6357:
6354:
6352:
6349:
6347:
6344:
6342:
6339:
6337:
6334:
6332:
6329:
6327:
6324:
6322:
6318:
6315:
6313:
6310:
6308:
6305:
6304:
6302:
6300:
6296:
6289:
6286:
6284:
6281:
6279:
6276:
6274:
6271:
6269:
6266:
6264:
6261:
6259:
6256:
6254:
6251:
6249:
6246:
6244:
6241:
6239:
6236:
6234:
6231:
6229:
6226:
6224:
6221:
6219:
6216:
6214:
6211:
6209:
6206:
6204:
6201:
6199:
6196:
6194:
6191:
6189:
6186:
6184:
6181:
6179:
6176:
6174:
6171:
6169:
6166:
6164:
6161:
6159:
6156:
6154:
6151:
6149:
6146:
6144:
6141:
6139:
6136:
6134:
6131:
6129:
6126:
6124:
6121:
6119:
6116:
6114:
6111:
6109:
6106:
6104:
6101:
6099:
6096:
6094:
6091:
6089:
6086:
6084:
6081:
6079:
6076:
6074:
6071:
6069:
6066:
6064:
6061:
6059:
6056:
6054:
6051:
6049:
6046:
6044:
6041:
6039:
6036:
6034:
6031:
6029:
6026:
6024:
6021:
6019:
6016:
6014:
6011:
6009:
6006:
6004:
6001:
5999:
5996:
5994:
5991:
5989:
5986:
5984:
5981:
5979:
5976:
5974:
5971:
5969:
5966:
5964:
5961:
5959:
5956:
5954:
5951:
5949:
5946:
5944:
5941:
5939:
5936:
5934:
5931:
5929:
5925:
5922:
5921:
5919:
5917:
5913:
5906:
5903:
5899:
5896:
5894:
5891:
5889:
5886:
5884:
5881:
5879:
5876:
5874:
5871:
5869:
5866:
5864:
5861:
5859:
5856:
5854:
5851:
5849:
5846:
5844:
5841:
5839:
5836:
5834:
5831:
5829:
5826:
5824:
5821:
5819:
5816:
5814:
5811:
5809:
5806:
5804:
5801:
5799:
5796:
5794:
5791:
5789:
5786:
5784:
5781:
5779:
5776:
5775:
5774:
5771:
5770:
5768:
5765:
5761:
5758:
5756:Miscellaneous
5754:
5743:
5740:
5738:
5735:
5733:
5729:
5726:
5724:
5721:
5719:
5716:
5714:
5711:
5708:
5705:
5703:
5700:
5698:
5694:
5691:
5688:
5685:
5683:
5680:
5678:
5675:
5673:
5670:
5668:
5664:
5661:
5658:
5655:
5653:
5650:
5648:
5645:
5643:
5639:
5636:
5634:
5631:
5628:
5625:
5623:
5619:
5616:
5614:
5611:
5608:
5605:
5603:
5599:
5596:
5593:
5589:
5585:
5582:
5580:
5577:
5575:
5572:
5570:
5566:
5563:
5561:
5558:
5555:
5552:
5550:
5546:
5543:
5540:
5537:
5535:
5532:
5530:
5527:
5525:
5522:
5520:
5516:
5513:
5510:
5507:
5505:
5502:
5500:
5497:
5495:
5492:
5490:
5487:
5485:
5482:
5480:
5477:
5475:
5472:
5470:
5467:
5465:
5461:
5458:
5456:
5453:
5451:
5448:
5446:
5443:
5440:
5437:
5435:
5431:
5428:
5425:
5422:
5420:
5417:
5415:
5411:
5408:
5406:
5403:
5400:
5397:
5395:
5392:
5390:
5386:
5383:
5379:
5376:
5374:
5371:
5370:
5369:
5366:
5363:
5360:
5358:
5354:
5351:
5349:
5346:
5341:
5338:
5336:
5332:
5329:
5326:
5323:
5321:
5318:
5316:
5313:
5312:
5311:
5308:
5306:
5303:
5300:
5297:
5295:
5291:
5288:
5285:
5282:
5280:
5276:
5274:
5270:
5269:Anaphylatoxin
5267:
5266:
5264:
5260:
5253:
5250:
5248:
5244:
5241:
5238:
5235:
5233:
5229:
5226:
5224:
5220:
5217:
5214:
5211:
5209:
5206:
5204:
5201:
5199:
5195:
5192:
5190:
5187:
5184:
5181:
5179:
5175:
5172:
5169:
5166:
5164:
5160:
5157:
5156:
5154:
5152:
5148:
5145:
5141:
5131:
5128:
5125:
5122:
5120:
5117:
5115:
5112:
5110:
5107:
5105:
5101:
5098:
5096:
5093:
5091:
5088:
5085:
5082:
5080:
5077:
5075:
5072:
5070:
5067:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5046:
5043:
5040:
5037:
5035:
5032:
5030:
5027:
5025:
5022:
5020:
5017:
5015:
5011:
5008:
5004:
5001:
4999:
4996:
4994:
4991:
4990:
4989:
4986:
4983:
4980:
4978:
4975:
4973:
4970:
4968:
4964:
4961:
4959:
4956:
4954:
4951:
4948:
4945:
4943:
4940:
4938:
4934:
4930:
4927:
4925:
4921:
4918:
4916:
4913:
4912:
4910:
4906:
4900:
4897:
4895:
4892:
4888:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4865:
4861:
4858:
4856:
4852:
4849:
4848:
4847:
4846:Prostaglandin
4844:
4842:
4839:
4837:
4834:
4830:
4827:
4825:
4822:
4821:
4820:
4817:
4814:
4811:
4809:
4805:
4802:
4801:
4799:
4797:
4793:
4790:
4784:
4773:
4770:
4768:
4765:
4763:
4760:
4758:
4755:
4753:
4750:
4748:
4744:
4741:
4738:
4735:
4733:
4730:
4728:
4724:
4721:
4717:
4714:
4712:
4709:
4707:
4704:
4702:
4699:
4698:
4697:
4694:
4692:
4689:
4685:
4682:
4680:
4677:
4675:
4672:
4670:
4667:
4665:
4662:
4661:
4660:
4657:
4654:
4651:
4649:
4646:
4644:
4641:
4639:
4636:
4634:
4630:
4629:Acetylcholine
4627:
4626:
4624:
4620:
4613:
4610:
4608:
4605:
4603:
4600:
4598:
4594:
4591:
4588:
4585:
4583:
4580:
4578:
4574:
4571:
4568:
4565:
4563:
4560:
4558:
4555:
4553:
4550:
4548:
4544:
4541:
4539:
4534:
4533:
4531:
4529:
4525:
4518:
4515:
4513:
4510:
4508:
4505:
4503:
4500:
4498:
4495:
4493:
4490:
4488:
4485:
4483:
4480:
4478:
4475:
4473:
4470:
4468:
4465:
4463:
4459:
4456:
4453:
4450:
4448:
4445:
4443:
4440:
4438:
4434:
4431:
4430:
4428:
4426:
4422:
4416:
4413:
4411:
4408:
4406:
4403:
4400:
4397:
4395:
4392:
4390:
4386:
4383:
4380:
4377:
4375:
4372:
4370:
4366:
4363:
4362:
4360:
4358:
4354:
4351:
4349:
4345:
4341:
4336:
4332:
4327:
4323:
4319:
4315:
4308:
4303:
4301:
4296:
4294:
4289:
4288:
4285:
4281:
4280:
4278:
4277:public domain
4274:
4263:
4259:
4255:
4251:
4247:
4243:
4239:
4234:
4230:
4226:
4222:
4218:
4213:
4209:
4205:
4201:
4197:
4191:
4187:
4183:
4178:
4173:
4169:
4165:
4161:
4157:
4153:
4148:
4144:
4140:
4136:
4132:
4126:
4122:
4118:
4113:
4108:
4105:(4): 2614–9.
4104:
4100:
4096:
4091:
4087:
4083:
4079:
4075:
4071:
4067:
4063:
4059:
4053:
4049:
4045:
4041:
4037:
4032:
4027:
4023:
4019:
4015:
4010:
4006:
4002:
3997:
3992:
3988:
3984:
3980:
3975:
3971:
3967:
3962:
3957:
3953:
3949:
3946:(5): 2243–9.
3945:
3941:
3937:
3932:
3928:
3924:
3920:
3916:
3912:
3908:
3902:
3898:
3894:
3890:
3886:
3883:(7): 684–96.
3882:
3878:
3873:
3869:
3865:
3861:
3857:
3853:
3849:
3844:
3840:
3836:
3832:
3828:
3823:
3818:
3814:
3810:
3806:
3802:
3796:
3792:
3788:
3783:
3778:
3773:
3768:
3764:
3760:
3756:
3752:
3748:
3743:
3739:
3735:
3731:
3727:
3723:
3719:
3714:
3710:
3706:
3702:
3698:
3695:(1): 263–70.
3694:
3690:
3685:
3681:
3677:
3672:
3667:
3663:
3659:
3655:
3650:
3646:
3642:
3639:(2): 213–20.
3638:
3634:
3628:
3624:
3620:
3615:
3610:
3606:
3602:
3598:
3594:
3590:
3585:
3581:
3577:
3573:
3569:
3565:
3561:
3556:
3555:
3550:
3538:on 2016-03-03
3537:
3533:
3529:
3521:
3520:
3516:
3499:
3495:
3491:
3485:
3482:
3470:
3466:
3460:
3457:
3444:
3440:
3436:
3430:
3427:
3414:
3410:
3406:
3400:
3397:
3392:
3388:
3383:
3378:
3373:
3368:
3364:
3360:
3356:
3349:
3347:
3345:
3341:
3336:
3332:
3328:
3324:
3320:
3316:
3313:(6): 1003–7.
3312:
3308:
3301:
3298:
3293:
3289:
3284:
3279:
3275:
3271:
3267:
3263:
3259:
3251:
3248:
3235:
3231:
3227:
3220:
3217:
3212:
3208:
3204:
3200:
3196:
3192:
3185:
3182:
3177:
3173:
3169:
3165:
3161:
3157:
3153:
3149:
3141:
3138:
3133:
3129:
3125:
3121:
3116:
3111:
3107:
3103:
3099:
3095:
3088:
3085:
3080:
3076:
3072:
3068:
3063:
3058:
3054:
3050:
3049:FASEB Journal
3046:
3039:
3036:
3031:
3027:
3023:
3019:
3015:
3008:
3006:
3002:
2997:
2993:
2989:
2985:
2980:
2975:
2971:
2967:
2963:
2956:
2953:
2948:
2944:
2939:
2934:
2931:(4): 279–85.
2930:
2926:
2922:
2915:
2912:
2907:
2903:
2898:
2893:
2890:(4): 639–49.
2889:
2885:
2881:
2874:
2872:
2868:
2863:
2859:
2854:
2849:
2845:
2841:
2837:
2833:
2829:
2822:
2820:
2816:
2811:
2807:
2803:
2799:
2795:
2791:
2787:
2783:
2776:
2774:
2772:
2768:
2763:
2759:
2754:
2749:
2745:
2741:
2737:
2730:
2728:
2726:
2724:
2722:
2720:
2716:
2711:
2707:
2703:
2699:
2695:
2691:
2687:
2683:
2676:
2673:
2668:
2664:
2659:
2654:
2649:
2644:
2640:
2636:
2632:
2625:
2623:
2621:
2617:
2612:
2608:
2603:
2598:
2594:
2590:
2586:
2582:
2579:(8): 848–66.
2578:
2574:
2570:
2563:
2560:
2547:
2543:
2539:
2533:
2530:
2525:
2521:
2515:
2512:
2500:
2496:
2490:
2487:
2482:
2478:
2473:
2468:
2464:
2460:
2456:
2449:
2447:
2445:
2443:
2441:
2439:
2437:
2435:
2433:
2431:
2429:
2425:
2413:
2409:
2403:
2400:
2395:
2391:
2385:
2382:
2377:
2373:
2367:
2364:
2360:
2356:
2351:
2349:
2347:
2343:
2339:
2335:
2330:
2328:
2326:
2322:
2315:
2311:
2308:
2306:
2303:
2301:
2298:
2296:
2293:
2292:
2288:
2286:
2284:
2280:
2275:
2269:
2265:
2262:in 5p13.1, a
2261:
2257:
2253:
2249:
2245:
2241:
2237:
2233:
2229:
2228:Meta-analysis
2226:
2222:
2217:
2207:
2206:gene promoter
2205:
2200:
2196:
2192:
2188:
2184:
2180:
2176:
2171:
2168:
2164:
2160:
2156:
2149:
2144:
2136:
2133:
2121:
2118:
2114:
2106:
2103:
2099:
2080:
2079:
2078:
2072:
2064:
2059:
2057:
2047:
2043:
2031:
2029:
2026:
2014:
2012:
1998:
1990:
1982:
1971:
1967:
1951:
1949:
1938:
1936:
1926:
1918:
1914:
1906:
1902:
1894:
1890:
1878:
1876:
1870:
1854:
1850:
1846:
1842:
1826:
1824:
1821:
1813:
1809:
1797:
1782:
1779:
1777:
1775:
1771:
1767:
1763:
1759:
1755:
1751:
1747:
1743:
1739:
1735:
1731:
1727:
1723:
1719:
1715:
1711:
1707:
1703:
1699:
1695:
1691:
1687:
1683:
1679:
1667:
1665:
1654:
1652:
1648:
1644:
1640:
1636:
1624:
1620:
1608:
1592:
1584:
1572:
1570:
1552:
1550:
1548:
1540:
1529:. That is, EP
1528:
1519:
1517:
1513:
1506:
1499:
1492:
1477:
1473:
1469:
1465:
1457:
1453:
1449:
1445:
1441:
1437:
1436:PI3K/AKT/mTOR
1429:
1425:
1421:
1417:
1413:
1409:
1405:
1401:
1397:
1393:
1389:
1381:
1365:
1357:
1353:
1345:
1333:
1331:
1325:
1317:
1315:
1313:
1309:
1305:
1301:
1284:
1280:
1268:
1260:
1256:
1252:
1248:
1244:
1232:
1224:
1219:
1217:
1216:fibroblasts.
1215:
1211:
1208:
1204:
1201:
1197:
1193:
1189:
1185:
1181:
1178:
1174:
1171:
1167:
1163:
1159:
1155:
1151:
1147:
1143:
1135:
1133:
1131:
1127:
1119:
1117:
1111:
1107:
1087:
1084:
1076:
1072:
1068:
1061:
1045:
1040:
1036:
1032:
1029:
1025:
1018:
1016:
1013:
1009:
1005:
1001:
998:
994:
990:
983:
981:
977:
971:
967:
964:
958:
956:
950:
946:
943:
939:
932:
930:
926:
920:
916:
913:
907:
905:
899:
895:
892:
890:RefSeq (mRNA)
888:
881:
880:
875:
871:
868:
862:
861:
856:
852:
849:
847:
843:
836:
835:
830:
826:
823:
817:
816:
811:
807:
804:
802:
798:
791:
790:
785:
781:
778:
772:
771:
766:
762:
759:
757:
753:
750:
747:
745:
742:
738:
735:
731:
727:
720:
716:
711:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
605:
602:
601:
599:
596:
595:
589:
586:
584:
581:
579:
576:
574:
571:
570:
568:
565:
564:
558:
555:
553:
550:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
497:
495:
491:
483:
478:
467:
463:
459:
455:
451:
447:
443:
439:
436:hair follicle
435:
431:
430:
427:
423:
418:
415:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
368:
365:
361:
356:
353:
352:
349:
347:
343:
341:
340:
336:
335:
332:
330:
326:
322:
318:
314:
306:
301:
297:
293:
288:
278:
274:
267:
260:
254:
247:
239:
235:
231:
226:
222:
217:
213:
205:
200:
196:
192:
187:
177:
173:
166:
159:
153:
146:
142:
136:
132:
128:
123:
119:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
9752:
9745:
9690:
9309:
9237:
9234:Propacetamol
9224:Parapropamol
9200:
9188:
9171:
9159:
9151:Floctafenine
9142:
9100:
9077:Azapropazone
9074:Pyrazolones:
9073:
9026:
9008:Tarenflurbil
8943:Flurbiprofen
8913:Dexibuprofen
8893:Benoxaprofen
8888:Alminoprofen
8884:
8811:Glucametacin
8722:
8699:Salicylamide
8689:Salacetamide
8630:
8579:Trimoprostil
8574:Tiprostanide
8559:Spiriprostil
8494:Naxaprostene
8444:Esuberaprost
8399:Cobiprostone
8197:Antagonists:
8196:
8160:
8131:Antagonists:
8130:
8124:Treprostinil
8032:
7964:Fluprostenol
7954:Cloprostenol
7935:
7849:
7816:Antagonists:
7815:
7781:Lubiprostone
7777:
7761:
7749:Antagonists:
7748:
7662:
7624:Antagonists:
7623:
7617:Treprostinil
7585:
7537:Antagonists:
7536:
7502:Lubiprostone
7478:
7373:Antagonists:
7372:
7354:
7316:Antagonists:
7315:
7309:Treprostinil
7297:
6945:
6912:
6885:Metabotropic
6749:
6634:
6587:
6545:
6511:
6482:
6453:
6298:
5923:
5772:
5723:Urotensin-II
5663:Somatostatin
5618:Prokineticin
5515:Melanocortin
5218:
5151:Neuropeptide
5090:Oxoglutarate
4932:
4894:Prostacyclin
4863:
4850:
4803:
4691:GHB receptor
4592:
4535:
4270:
4269:
4245:
4241:
4220:
4216:
4199:
4195:
4162:(2): 263–9.
4159:
4155:
4137:(1): 28–32.
4134:
4130:
4102:
4098:
4061:
4057:
4021:
4018:FEBS Letters
4017:
3986:
3982:
3943:
3939:
3910:
3906:
3880:
3876:
3851:
3847:
3807:(6): 333–6.
3804:
3800:
3754:
3750:
3724:(1): 182–8.
3721:
3717:
3692:
3688:
3661:
3657:
3636:
3632:
3596:
3592:
3566:(3): 740–2.
3563:
3559:
3540:. Retrieved
3536:the original
3531:
3502:. Retrieved
3493:
3484:
3473:. Retrieved
3459:
3447:. Retrieved
3438:
3429:
3417:. Retrieved
3408:
3399:
3362:
3358:
3310:
3306:
3300:
3268:(8): 761–7.
3265:
3261:
3250:
3238:. Retrieved
3229:
3219:
3194:
3190:
3184:
3151:
3147:
3140:
3100:(4): 813–9.
3097:
3094:Neuroscience
3093:
3087:
3052:
3048:
3038:
3013:
2969:
2965:
2955:
2928:
2924:
2914:
2887:
2883:
2835:
2831:
2785:
2781:
2746:(1): 57–71.
2743:
2739:
2685:
2681:
2675:
2638:
2634:
2576:
2572:
2562:
2550:. Retrieved
2541:
2532:
2514:
2503:. Retrieved
2489:
2462:
2458:
2416:. Retrieved
2402:
2393:
2384:
2375:
2366:
2282:
2276:
2267:
2255:
2247:
2243:
2235:
2224:
2220:
2218:
2203:
2178:
2172:
2158:
2153:
2068:
2035:
2018:
1987:inhibit the
1955:
1942:
1882:
1830:
1785:
1774:hyperalgesia
1761:
1749:
1741:
1725:
1717:
1705:
1697:
1671:
1668:Inflammation
1655:
1639:indomethacin
1576:
1556:
1520:
1428:angiogenesis
1412:somatostatin
1337:
1321:
1308:osteoporosis
1228:
1200:conjunctival
1198:epithelium,
1162:tunica media
1139:
1123:
1082:
1063:
1055:
1054:
976:NP_001129551
973:
952:
925:NM_001136079
922:
901:
877:
858:
832:
813:
787:
768:
748:
743:
344:
337:
64:External IDs
9691:Precursors:
9631:Nicogrelate
9611:Furegrelate
9552:Bimatoprost
9462:Trifenagrel
9452:Tiflamizole
9422:Rutecarpine
9407:Resveratrol
9348:Glimepiride
9313:Anitrazafen
9291:Robenacoxib
9271:Lumiracoxib
9204:Acetanilide
9146:Antrafenine
9104:Ampiroxicam
8998:Pranoprofen
8983:Naproxcinod
8876:Zidometacin
8801:Fenclofenac
8726:Aceclofenac
8664:Ethenzamide
8659:Dipyrocetyl
8554:Rosaprostol
8534:Posaraprost
8519:Penprostene
8509:Ornoprostil
8489:Mexiprostil
8484:Meteneprost
8439:Eptaloprost
8414:Dimoxaprost
8379:Arbaprostil
8333:Seratrodast
8225:BMS-180,291
8056:Carbacyclin
8006:Unoprostone
7986:(dinoprost)
7969:Latanoprost
7944:Bimatoprost
7939:Alfaprostol
7895:(dinoprost)
7834:ONO-AE3-208
7786:Misoprostol
7742:Sulprostone
7732:Remiprostol
7701:Misoprostol
7696:Latanoprost
7671:Carbacyclin
7632:PF-04418948
7594:Misoprostol
7530:Sulprostone
7507:Misoprostol
7497:Latanoprost
7431:Vidupiprant
7421:Timapiprant
7416:Setipiprant
7391:Fevipiprant
7358:Indometacin
7329:Vidupiprant
7324:Laropiprant
6593:Latrophilin
5728:Vasopressin
5713:Thyrotropin
5290:Angiotensin
5243:Neurotensin
4920:Cannabinoid
4899:Thromboxane
3822:2433/160737
3115:2433/120543
2838:(1): 21–8.
2641:: 1324347.
2264:Gene desert
1883:In mice, EP
1869:osteoblasts
1818:stimulates
1738:macrophages
1688:-producing
1516:Gβγ complex
1456:mitogenesis
1386:stimulates
1322:Inhibitory
1267:double bond
1231:prostanoids
1205:cells, and
1188:keratocytes
1140:In humans,
1106:prostanoids
639:JNK cascade
460:Paneth cell
202:40,693,735
189:40,679,915
42:Identifiers
9770:Categories
9661:Samixogrel
9656:Rolafagrel
9641:Picotamide
9621:Midazogrel
9596:Camonagrel
9457:Timegadine
9402:Pamicogrel
9373:Licofelone
9353:Hyperforin
9318:Clobuzarit
9306:Valdecoxib
9301:Tilmacoxib
9286:Polmacoxib
9261:Etoricoxib
9229:Phenacetin
9197:Nimesulide
9175:Clonixeril
9168:Proquazone
9124:Lornoxicam
9023:Vedaprofen
8973:Miroprofen
8968:Loxoprofen
8963:Ketoprofen
8958:Indoprofen
8933:Fenoprofen
8846:Oxametacin
8841:Nabumetone
8781:Diclofenac
8776:Clometacin
8771:Cinmetacin
8766:Bumadizone
8746:Alclofenac
8731:Acemetacin
8669:Guacetisal
8654:Diflunisal
8604:inhibitors
8569:Tilsuprost
8549:Rivenprost
8544:Rioprostil
8539:Prostalene
8524:Pimilprost
8514:Oxoprostol
8504:Nocloprost
8479:Luprostiol
8469:Lanproston
8464:Froxiprost
8459:Flunoprost
8449:Etiproston
8434:Enisoprost
8429:Eganoprost
8389:Ciprostene
8358:Terutroban
8348:Sulotroban
8328:Samixogrel
8313:Ramatroban
8300:Picotamide
8285:Mipitroban
8280:Linotroban
8265:Imitrodast
8255:ICI-192605
8250:ICI-185282
8235:Domitroban
8215:Argatroban
8114:Taprostene
8036:ACT-333679
8001:Travoprost
7996:Tafluprost
7991:Sulotroban
7949:Carboprost
7905:Taprenepag
7886:Omidenepag
7881:Nocloprost
7871:Evatanepag
7866:Carboprost
7819:Grapiprant
7411:Ramatroban
7319:Asapiprant
7239:modulators
7233:Prostanoid
7183:Smoothened
7176:Smoothened
7099:Smoothened
6758:Calcitonin
5693:Tachykinin
5590:, but not
5584:Nociceptin
5450:Kisspeptin
5368:Endothelin
5331:Bradykinin
5219:Neuromedin
4796:Eicosanoid
4425:Purinergic
4357:Adrenergic
3542:2008-12-09
3475:2017-02-19
2505:2017-02-06
2418:2017-01-24
2361:, May 2017
2340:, May 2017
2316:References
2199:urticarial
2195:angioedema
2091:rivenprost
1989:metastasis
1970:xenografts
1966:metastasis
1841:osteoclast
1708:stimulate
1690:Th17 cells
1525:undergoes
1464:proteasome
1352:G proteins
1136:Expression
1060:receptor 4
464:left colon
378:glomerulus
348:(ortholog)
303:5,273,668
290:5,236,142
85:HomoloGene
9666:Terbogrel
9646:Pirmagrel
9606:Dazoxiben
9601:Dazmegrel
9494:Retinoids
9412:Romazarit
9358:Itazigrel
9343:FR-122047
9338:Flumizole
9296:Rofecoxib
9281:Parecoxib
9276:Mavacoxib
9266:Firocoxib
9256:Deracoxib
9251:Cimicoxib
9246:Celecoxib
9241:Apricoxib
9192:Flosulide
9156:Glafenine
9139:Tenoxicam
9134:Piroxicam
9129:Meloxicam
9013:Tepoxalin
8993:Pirprofen
8988:Oxaprozin
8953:Ibuproxam
8948:Ibuprofen
8908:Carprofen
8903:Butibufen
8881:Zomepirac
8851:Oxindanac
8836:Mofezolac
8831:Lonazolac
8826:Ketorolac
8806:Fentiazac
8761:Bufexamac
8756:Bromfenac
8736:Aclofenac
8719:Triflusal
8709:Salsalate
8634:Aloxiprin
8584:Viprostol
8529:Piriprost
8499:Nileprost
8474:Limaprost
8424:Ecraprost
8419:Doxaprost
8409:Deprostil
8394:Clinprost
8353:Terbogrel
8343:SQ-29,548
8338:SQ-28,668
8295:ONO-11120
8260:Ifetroban
8230:Daltroban
8220:Bay U3405
8190:Vapiprost
8161:Agonists:
8134:RO1138452
8109:Selexipag
8104:Ralinepag
8061:Cicaprost
8051:BMY-45778
8046:Beraprost
8033:Agonists:
7959:Enprostil
7936:Agonists:
7900:Simenepag
7876:Gemeprost
7850:Agonists:
7824:GW-627368
7778:Agonists:
7681:Enprostil
7676:Cicaprost
7666:Beraprost
7663:Agonists:
7589:Butaprost
7586:Agonists:
7487:Enprostil
7482:Beraprost
7479:Agonists:
7386:Bay U3405
7355:Agonists:
7298:Agonists:
7236:signaling
7093:Class F:
6892:pheromone
6888:glutamate
6312:Olfactory
5348:Chemokine
5130:Succinate
4915:Bile acid
4723:Melatonin
4696:Histamine
4536:(all but
4528:Serotonin
4433:Adenosine
4335:Rhodopsin
3014:Biochimie
2266:close to
2085:agonist,
2069:Clinical
1770:allodynia
1758:capillary
1754:arteriole
1734:apoptosis
1553:Functions
1466:protein,
1229:Standard
1180:aneurysms
1158:glomeruli
980:NP_032991
955:NP_000949
929:NM_008965
904:NM_000958
734:Orthologs
93:GeneCards
9742:See also
9651:Ridogrel
9626:Nafagrel
9616:Isbogrel
9499:Selenium
9467:Tropesin
9442:SC-58125
9427:Satigrel
9392:NCX-4040
9368:L-670596
9363:L-655240
9323:Curcumin
9185:Flunixin
9180:Clonixin
9119:Isoxicam
9114:Enolicam
9109:Droxicam
9087:Isopyrin
9082:Dipyrone
9003:Suprofen
8978:Naproxen
8928:Fenbufen
8871:Tolmetin
8861:Sulindac
8796:Felbinac
8791:Etodolac
8751:Bendazac
8564:Tiaprost
8384:Ataprost
8372:Unsorted
8318:Ridogrel
8290:ONO-3708
8275:L-670596
8270:L-655240
8245:GR-32191
7861:Aganepag
7843:Unsorted
7829:L-161982
7809:TCS-2510
7752:L-798106
7637:TG 4-155
7560:SC-51322
7555:SC-51089
7550:SC-19220
7545:ONO-8130
7381:AZD-1981
7376:ADC-3680
7247:Receptor
7117:Frizzled
7110:Frizzled
7095:Frizzled
6937:, type 2
6843:Secretin
6783:Glucagon
6488:Cadherin
6446:Adhesion
6433:Secretin
5766:, bitter
5613:Oxytocin
5310:Bombesin
4958:Estrogen
4659:Dopamine
4262:12149218
4229:11951086
4223:: 51–8.
4208:11948128
4186:11876748
4143:11782353
4121:11706038
4086:25415232
4078:11597569
4048:29938003
4040:11470276
4005:11423555
3970:11344234
3927:11093764
3897:10880739
3839:20377539
3718:Genomics
3623:25623334
3560:Genomics
3498:Archived
3469:Archived
3443:Archived
3413:Archived
3391:27708579
3335:25930196
3327:25935456
3292:21743469
3234:Archived
3224:snpdev.
3211:28169162
3168:27925221
3132:23372528
3124:19303430
3079:28363263
3071:26271253
3030:25179301
2996:32049750
2988:11299240
2947:11001172
2906:25343148
2862:22187483
2802:27940058
2788:: 7–19.
2762:27506873
2702:10508233
2667:27190998
2611:20948178
2546:Archived
2524:Archived
2499:Archived
2481:21752876
2412:Archived
2357:–
2336:–
2289:See also
2258:certain
2219:Several
2175:genotype
1845:IL-1beta
1820:duodenum
1810:such as
1678:IL-12p70
1444:p38 MAPK
1358:(i.e. Gα
1269:than PGE
1214:gingival
1096:, and EP
1028:Wikidata
713:Sources:
578:membrane
9671:U63557A
9636:Ozagrel
9447:Tenidap
9387:NCX-466
9333:FK-3311
9328:DuP-697
9214:Bucetin
8741:Amfenac
8694:Salicin
8363:TRA-418
8210:AA-2414
8200:12-HETE
8185:U-46619
8119:TRA-418
8076:MRE-269
7627:AH-6809
7540:AH-6809
7426:TM30089
7406:QAV-680
7401:MK-7246
7396:MK-1029
7253:ligands
6906:, sweet
6881:Class C
6813:PACAPR1
6429:Class B
5638:Relaxin
5560:Motilin
5445:Ghrelin
5410:Galanin
5143:Peptide
4331:Class A
4177:1906325
3961:2694306
3868:9214685
3831:8862514
3791:8855294
3759:Bibcode
3738:8661119
3709:8250933
3680:8163486
3645:8078484
3614:4417504
3580:7759114
3382:5030812
3365:: 316.
3283:3640413
3176:4170611
2853:3249979
2810:1513449
2710:7766467
2658:4846751
2602:3037517
2581:Bibcode
2359:Ensembl
2338:Ensembl
2260:alleles
2173:The GG
2098:phase 2
2025:cochlea
2015:Hearing
1972:. An EP
1915:by the
1851:-, and
1796:colitis
1722:B cells
1613:and PGE
1366:(i.e. G
1279:Ki=3 nM
1220:Ligands
1210:stromal
1203:stromal
1196:ciliary
1184:corneal
1069:) is a
846:UniProt
801:Ensembl
740:Species
719:QuickGO
323:pattern
49:Aliases
9684:Others
9533:HQL-79
9437:SC-560
9432:SC-236
9397:NS-398
8598:Enzyme
8240:EP-045
8205:13-APA
8145:TP (TX
8081:NS-304
8041:AFP-07
7097:&
7026:GPRC6A
6763:CALCRL
6627:Orphan
5916:Orphan
5907:type 1
5598:Orexin
5586:&
5565:Opioid
5305:Apelin
4260:
4227:
4206:
4184:
4174:
4141:
4119:
4084:
4076:
4046:
4038:
4003:
3968:
3958:
3925:
3895:
3866:
3837:
3829:
3789:
3779:
3736:
3707:
3678:
3643:
3621:
3611:
3578:
3389:
3379:
3333:
3325:
3290:
3280:
3209:
3174:
3166:
3130:
3122:
3077:
3069:
3028:
2994:
2986:
2945:
2904:
2860:
2850:
2808:
2800:
2760:
2708:
2700:
2665:
2655:
2609:
2599:
2479:
2283:PTGER4
2268:PTGER4
2248:PTERG4
2236:PTGER4
2221:PTGER4
2204:PTGER4
2191:wheals
2179:PTGER4
2159:PTGER4
2122:The EP
2107:The EP
1956:The EP
1952:Cancer
1712:(i.e.
1601:by PGE
1442:, and
1414:, and
1400:kinase
1326:for EP
1207:iridal
1083:PTGER4
1014:search
1012:PubMed
879:P32240
860:P35408
756:Entrez
494:BioGPS
456:uterus
181:5p13.1
97:PTGER4
81:104311
73:601586
56:PTGER4
33:PTGER4
18:PTGER4
8323:S-145
8172:I-BOP
8017:IP (I
7920:FP (F
7446:EP (E
7265:DP (D
6946:Other
6913:TAS1R
6904:Taste
6802:GLP2R
6797:GLP1R
6750:Other
6615:ELTD1
6588:ADGRL
6546:ADGRG
6512:ADGRE
6483:ADGRC
6454:ADGRB
6435:-like
6317:Opsin
6299:Other
5773:TAS2R
5764:Taste
5592:Sigma
5574:Kappa
5569:Delta
5277:C5a (
5262:Other
4908:Other
4836:FPRL1
4804:CysLT
4622:Other
4573:5-HT2
4543:5-HT1
4538:5-HT3
4337:-like
4242:Blood
4082:S2CID
4044:S2CID
3835:S2CID
3782:38269
3504:6 May
3449:6 May
3419:6 May
3331:S2CID
3240:6 May
3172:S2CID
3128:S2CID
3075:S2CID
2992:S2CID
2806:S2CID
2706:S2CID
2552:6 May
2252:NF-κB
2003:or EP
1879:Heart
1686:IL-17
1682:IL-23
1607:fetus
1408:c-fos
1374:and G
1243:PGF2α
1237:: PGE
1112:). EP
1108:(see
789:19219
749:Mouse
744:Human
715:Amigo
468:ileum
448:blood
346:Mouse
339:Human
286:Start
221:Mouse
185:Start
118:Human
89:20261
9584:TXAS
9542:PGFS
9523:PGES
8621:PTGS
7051:RAIG
6959:GABA
6792:GIPR
6539:CD97
6387:SREB
6188:137B
6163:109B
6158:109A
5588:Zeta
5545:MCHR
5325:NMBR
5320:GRPR
5315:BRS3
4953:EBI2
4819:LTB4
4743:TAAR
4593:5-HT
4258:PMID
4225:PMID
4204:PMID
4182:PMID
4139:PMID
4117:PMID
4074:PMID
4036:PMID
4001:PMID
3966:PMID
3923:PMID
3893:PMID
3864:PMID
3827:PMID
3787:PMID
3734:PMID
3705:PMID
3676:PMID
3641:PMID
3619:PMID
3576:PMID
3506:2018
3451:2018
3421:2018
3387:PMID
3323:PMID
3288:PMID
3242:2018
3207:PMID
3164:PMID
3120:PMID
3067:PMID
3026:PMID
2984:PMID
2943:PMID
2902:PMID
2858:PMID
2798:PMID
2758:PMID
2698:PMID
2663:PMID
2639:2016
2607:PMID
2554:2018
2477:PMID
2193:and
1903:and
1827:Bone
1772:and
1756:and
1625:, EP
1621:and
1500:and
1468:p105
1458:. EP
1454:and
1448:EGR1
1430:. EP
1404:CREB
1398:, a
1392:cAMP
1261:(PGE
1255:TXA2
1251:PGD2
1249:>
1247:PGI2
1241:>
1160:and
1142:mRNA
1120:Gene
1092:, EP
1086:gene
1077:(PGE
1073:for
770:5734
329:Bgee
277:Band
238:Chr.
176:Band
135:Chr.
69:OMIM
9561:PGI
9478:PGD
8616:COX
7045:179
7040:158
7035:156
7031:GPR
6818:GPR
6739:157
6734:155
6729:144
6724:143
6719:133
6714:128
6709:126
6704:125
6699:124
6694:123
6689:116
6684:115
6679:114
6674:113
6669:112
6664:111
6659:110
6635:GPR
6517:EMR
6356:RRH
6351:RGR
6346:1SW
6341:1MW
6336:1LW
6288:183
6283:182
6278:177
6273:176
6268:174
6263:173
6258:171
6253:162
6248:161
6243:160
6238:153
6233:152
6228:151
6223:150
6218:149
6213:148
6208:146
6203:142
6198:141
6193:139
6183:135
6178:132
6173:120
6168:119
6153:103
6148:101
5924:GPR
5460:MAS
5405:FSH
5273:C3a
5159:B/W
5095:PAF
4947:119
4933:GPR
4929:CB2
4924:CB1
4885:),
4862:),
4841:OXE
4458:P2Y
4447:A2B
4442:A2A
4250:doi
4246:100
4172:PMC
4164:doi
4160:127
4107:doi
4103:277
4066:doi
4026:doi
4022:501
3991:doi
3987:276
3956:PMC
3948:doi
3915:doi
3885:doi
3856:doi
3817:hdl
3809:doi
3777:PMC
3767:doi
3726:doi
3697:doi
3693:197
3666:doi
3662:269
3609:PMC
3601:doi
3568:doi
3377:PMC
3367:doi
3315:doi
3278:PMC
3270:doi
3199:doi
3156:doi
3110:hdl
3102:doi
3098:160
3057:doi
3018:doi
2974:doi
2970:280
2933:doi
2892:doi
2848:PMC
2840:doi
2836:188
2790:doi
2786:796
2748:doi
2690:doi
2653:PMC
2643:doi
2597:PMC
2589:doi
2467:doi
2281:of
2230:of
2032:Eye
2019:EP4
1847:-,
1835:-EP
1653:).
1440:ERK
1396:PKA
1281:) (
1132:).
502:n/a
299:End
198:End
101:OMA
77:MGI
9772::
9509:,
9505:,
9308:;
9236:;
9199:;
9187:;
9170:;
9158:;
9141:;
9099:;
9072:;
9025:;
8883:;
8721:;
8147:A2
7984:2α
7922:2α
7893:2α
7763:EP
7648:EP
7571:EP
7464:EP
7340:DP
7283:DP
7166:10
7022:))
6890:/
6883::
6787:GR
6654:98
6649:97
6644:64
6639:56
6431::
6143:92
6138:88
6133:87
6128:85
6123:84
6118:83
6113:82
6108:81
6103:78
6098:75
6093:68
6088:65
6083:63
6078:62
6073:61
6068:55
6063:52
6058:50
6053:45
6048:44
6043:42
6038:39
6033:37
6028:35
6023:34
6018:33
6013:32
6008:31
6003:27
5998:26
5993:25
5988:23
5983:22
5978:21
5973:20
5968:19
5963:18
5958:17
5953:15
5948:12
5898:60
5893:50
5888:46
5883:45
5878:43
5873:42
5868:41
5863:40
5858:39
5853:38
5848:31
5843:30
5838:20
5833:19
5828:16
5823:14
5818:13
5813:10
5737:1B
5732:1A
5579:Mu
5509:X4
5504:X3
5499:X2
5494:X1
5469:1L
5340:B2
5335:B1
5286:))
5239:))
5174:FF
4949:))
4942:55
4937:18
4931:,
4887:FP
4864:EP
4851:DP
4737:1C
4732:1B
4727:1A
4716:H4
4711:H3
4706:H2
4701:H1
4684:D5
4679:D4
4674:D3
4669:D2
4664:D1
4653:M5
4648:M4
4643:M3
4638:M2
4633:M1
4602:5A
4517:14
4512:13
4507:12
4502:11
4497:10
4452:A3
4437:A1
4415:β3
4410:β2
4405:β1
4385:α2
4365:α1
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4316::
4256:.
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4240:.
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