816:
4273:
4303:
793:
4423:
4288:
4768:
4183:
4528:
4213:
4198:
5233:
5218:
5203:
5188:
5173:
4693:
690:
715:
5158:
5143:
5128:
5113:
5098:
4708:
4078:
4153:
4138:
4753:
4468:
4453:
4228:
4483:
4348:
4243:
4258:
4738:
4168:
4678:
4498:
4888:
5023:
4723:
4873:
4783:
4513:
5383:
5368:
4858:
4843:
4828:
4813:
4798:
4663:
4438:
5053:
5038:
4543:
1852:
5413:
4063:
4648:
4633:
5428:
5398:
5008:
5353:
5338:
5323:
5308:
5293:
5278:
5263:
4993:
4558:
5458:
5443:
4963:
4408:
4393:
1823:
residue are located on the surface of the protein, and thus help to determine the depth a substrate can obtain within the cleft. This acts as a means of driving selectivity, as substrates containing smaller phosphoresidues cannot reach the site of catalytic activity at the base of the cleft. Upon substrate binding, PTP1B undergoes a structural modification in which the WPD loop closes around the substrate, introducing stabilizing
4948:
4933:
4918:
4903:
5068:
4378:
4333:
4318:
4363:
822:
721:
4618:
4603:
4588:
4573:
5083:
5248:
4093:
31:
4978:
5488:
5473:
4108:
4123:
1896:, which is converted to a sulfenyl amide after reacting with the adjacent Ser216 residue. This modification of the Cys215 residue prevents further oxidation of the residue which would be irreversible, and also induces a structural change in the cleft of the active site such that substrates may not bind. This oxidation can be reversed through reduction by
1822:
The first crystal structure of the PTP1B catalytic domain revealed that the catalytic site exists within a deep cleft of the protein formed by three loops including the WPD loop with the Asp181 residue, a pTyr loop with the Tyr46 residue and a Q loop with the Gln262 residue. The pTyr loop and Tyr46
1987:
Although PTP1B is generally studied as a regulator of metabolism, some research suggest it may have a role in tumor development, though whether it is oncogenic or tumor suppressive is unclear, as there is data in support of both arguments. The high ROS concentrations within cancer cells provide an
1839:
The phosphatase activity of PTP1B occurs via a two-step mechanism. The dephosphorylation of the pTyr substrate occurs in the first step, while the enzyme intermediates are broken down during the second step. During the first step, there is a nucleophilic attack at the phosphocenter by the reduced
2641:
Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, Ramachandran C, Gresser MJ, Tremblay ML, Kennedy BP (March 1999). "Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene".
57:
4272:
4302:
4422:
4287:
2304:
Julien SG, Dubé N, Read M, Penney J, Paquet M, Han Y, Kennedy BP, Muller WJ, Tremblay ML (2007). "Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis".
4767:
4182:
4527:
4212:
2800:"Regulation of Insulin-Like Growth Factor Type I (IGF-I) Receptor Kinase Activity by Protein Tyrosine Phosphatase 1B (PTP-1B) and Enhanced IGF-I-Mediated Suppression of Apoptosis and Motility in PTP-1B-Deficient Fibroblasts"
4197:
5232:
5217:
5202:
5187:
5172:
1900:
and acts as a means of regulating PTP1B activity. Phosphorylation of the Ser50 residue has also been shown as a point of allosteric regulation of PTP1B, in which the phosphorylated state of the enzyme is inactive.
4692:
5157:
5142:
5127:
5112:
5097:
4707:
4077:
3838:
Figueiredo H, Figueroa AL, Garcia A, Fernandez-Ruiz R, Broca C, Wojtusciszyn A, et al. (June 2019). "Targeting pancreatic islet PTP1B improves islet graft revascularization and transplant outcomes".
3750:"Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein"
4152:
2498:
Frangioni JV, Beahm PH, Shifrin V, Jost CA, Neel BG (February 1992). "The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence".
4137:
4752:
1996:, that up to 40% of the Cys215 residues in PTP1B can be selectively irreversibly oxidized under these cellular conditions resulting in non-functional PTP1B. In addition, PTPN1 genetic ablation in
4467:
4452:
4227:
4482:
3669:
Sarmiento M, Puius YA, Vetter SW, Keng YF, Wu L, Zhao Y, Lawrence DS, Almo SC, Zhang ZY (July 2000). "Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition".
4347:
4242:
4257:
2601:
Seely BL, Staubs PA, Reichart DR, Berhanu P, Milarski KL, Saltiel AR, Kusari J, Olefsky JM (October 1996). "Protein tyrosine phosphatase 1B interacts with the activated insulin receptor".
2000:
deficient mice resulted in an increased incidence of lymphomas and a decrease in overall survival rates. In contrast, the PTPN1 gene has been shown to be overexpressed in conjunction with
4737:
4167:
5528:
4677:
4497:
3892:
Thareja S, Aggarwal S, Bhardwaj TR, Kumar M (2012). "Protein tyrosine phosphatase 1B inhibitors: a molecular level legitimate approach for the management of diabetes mellitus".
4887:
3520:
Salmeen A, Andersen JN, Myers MP, Meng TC, Hinks JA, Tonks NK, Barford D (2003). "Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate".
5022:
4722:
829:
728:
2690:
Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB (August 2000).
2185:
Combs AP (March 2010). "Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer".
4872:
4782:
4512:
5382:
5367:
4857:
4842:
4827:
4812:
4797:
2987:"Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration"
4662:
1864:
The Cys215 residue is essential for the enzymatic activity of PTP1B and similar cysteine residues are required for the activity of other members of the Class I
4437:
5052:
5037:
4281:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A TRI-PHOSPHORYLATED PEPTIDE (RDI(PTR)ETD(PTR)(PTR)RK) FROM THE INSULIN RECEPTOR KINASE
4542:
1755:. PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of
5521:
4311:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A BIS-PHOSPHORYLATED PEPTIDE (ETD(PTR)(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE
1872:(ROS) in the cell which would render the enzyme non-functional. This cysteine residue has been shown to oxidize under increased cellular concentrations of
5412:
4062:
4647:
4632:
4431:: Crystal structure of PTP1B complexed with 7-(1,1-Dioxo-1H-benzoisothiazol-3-yloxymethyl)-2-(oxalyl-amino)-4,7-dihydro-5H-thienopyran-3-carboxylic acid
4296:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A MONO-PHOSPHORYLATED PEPTIDE (ETDY(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE
1767:
PTP1B was first isolated from a human placental protein extract, but it is expressed in many tissues. PTP1B is localized to the cytoplasmic face of the
1466:
5427:
5397:
5007:
1447:
651:
5352:
5337:
5322:
5307:
5292:
5277:
5262:
4992:
4557:
1956:
as well as cancer. Gene knockout studies conducted in murine models has provided substantial evidence for the role PTP1B plays in the regulation of
5457:
5442:
4962:
4407:
4392:
1759:. It has also been implicated in the development of breast cancer and has been explored as a potential therapeutic target in that avenue as well.
4947:
4932:
4917:
4902:
3382:"Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade"
5514:
5067:
3986:"Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development"
3574:
van
Montfort RL, Congreve M, Tisi D, Carr R, Jhoti H (2003). "Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B".
4776:: DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATE HEAD ON THE FIRST SITE
4377:
4332:
4317:
4191:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENOPYRAN-3-CARBOXYLIC ACID
2692:"Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice"
6292:
4042:
2108:
1780:
4362:
2090:
4617:
4602:
4587:
4572:
3133:"The Nonreceptor Protein Tyrosine Phosphatase PTP1B Binds to the Cytoplasmic Domain of N-Cadherin and Regulates the Cadherin–Actin Linkage"
2906:
Zhu S, Bjorge JD, Fujita DJ (November 2007). "PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation".
1934:
1784:
5082:
4536:: POTENT, SELECTIVE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B USING A SECOND PHOSPHOTYROSINE BINDING SITE, complexed with compound 19.
4221:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENOPYRIDINE-3-CARBOXYLIC ACID
5247:
4092:
4977:
815:
1681:
1674:
5487:
5472:
792:
4206:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENOPYRAN-3-CARBOXYLIC ACID
1918:
1776:
4107:
5241:: STRUCTURAL INSIGHTS INTO THE DESIGN OF NONPEPTIDIC ISOTHIAZOLIDINONE-CONTAINING INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B
5226:: STRUCTURAL INSIGHTS INTO THE DESIGN OF NONPEPTIDIC ISOTHIAZOLIDINONE-CONTAINING INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B
5211:: STRUCTURAL INSIGHTS INTO THE DESIGN OF NONPEPTIDIC ISOTHIAZOLIDINONE-CONTAINING INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B
5196:: STRUCTURAL INSIGHTS INTO THE DESIGN OF NONPEPTIDIC ISOTHIAZOLIDINONE-CONTAINING INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B
5181:: STRUCTURAL INSIGHTS INTO THE DESIGN OF NONPEPTIDIC ISOTHIAZOLIDINONE-CONTAINING INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B
2077:
2056:
1942:
1775:
kinase. In mice, genetic ablation of PTPN1 results in enhanced insulin sensitivity. Several other tyrosine kinases, including
4701:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE-CONTAINING TETRA-PEPTIDE (AC-DEPYL-NH2)
714:
689:
2073:
5166:: STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS
5151:: STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS
5136:: STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS
5121:: STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS
5106:: STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS
4716:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE-CONTAINING HEXA-PEPTIDE (DADEPYL-NH2)
4122:
1848:
interactions of Gln262 and Asp181 that help to position in the water molecule at the desired site of nucleophillic attack.
54:
5570:
1976:
counterparts. As such, the design and development of PTP1B inhibitors is a growing field of research for the treatment of
1930:
4086:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES
2052:
1844:
phenol. The active enzyme is regenerated after the thiophosphate intermediate is hydrolyzed, which is facilitated by the
6248:
6213:
6195:
5790:
5554:
5541:
3033:"Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)"
2029:
1865:
1745:
631:
2944:
Myers MP, Andersen JN, Cheng A, Tremblay ML, Horvath CM, Parisien JP, Salmeen A, Barford D, Tonks NK (December 2001).
1910:
828:
727:
3331:
Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T (2004).
4161:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID
2741:"Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases"
4146:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID
3423:"Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor"
1988:
environment for potential constitutive inactivation of PTP1B and it has been shown in two human cancer cell lines
821:
720:
4035:
5545:
4761:: Crystal structure of protein tyrosine phosphatase 1B with potent and selective bidentate inhibitor compound 2
1511:
639:
1885:
1869:
1492:
622:, PTP1B, protein tyrosine phosphatase, non-receptor type 1, protein tyrosine phosphatase non-receptor type 1
2128:"Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B"
2012:
overexpression in conjunction with PTPN1 knockout resulted in delayed tumor growth and with fewer observed
4476:: Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Compound 23 Using a Linked-Fragment Strategy
4461:: Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Compound 12 Using a Linked-Fragment Strategy
4236:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID
3288:
Barford D, Flint AJ, Tonks NK (March 1994). "Crystal structure of human protein tyrosine phosphatase 1B".
1868:
family. The thiolate anion form is needed for nucleophilic activity but it is susceptible to oxidation by
4491:: Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Compound 5 Using a Linked-Fragment Strategy
5506:
4356:: RESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITY OF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA
3630:"Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor"
1800:
1768:
703:
4251:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-D-A-D-BPA-PTYR-L-I-P-Q-Q-G
3937:"Protein tyrosine phosphatases — from housekeeping enzymes to master regulators of signal transduction"
3791:"PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells"
4266:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2
4028:
3583:
3529:
3475:
3297:
3085:
2860:
2849:"Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling"
2752:
2651:
2555:
2452:
2139:
618:
4746:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO PHOSPHOTYROSINE MOLECULES
4176:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID
1632:
1585:
6051:
3917:
3874:
3607:
3553:
3499:
3362:
3267:
2524:
2330:
1262:
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
663:
6084:
1657:
1636:
1606:
1581:
4007:
3966:
3909:
3866:
3820:
3771:
3727:
3686:
3651:
3599:
3545:
3491:
3444:
3403:
3354:
3313:
3259:
3213:
3162:
3113:
3054:
3008:
2967:
2923:
2888:
2829:
2780:
2721:
2667:
2618:
2583:
2516:
2480:
2421:
2374:
2322:
2283:
2237:
2202:
2167:
1873:
611:
47:
5981:
5976:
5945:
5862:
4686:: Non-carboxylic Acid-Containing Inhibitor of PTP1B Targeting the Second Phosphotyrosine Site
2544:"Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes"
2126:
Brown-Shimer S, Johnson KA, Lawrence JB, Johnson C, Bruskin A, Green NR, Hill DE (Aug 1990).
6177:
6167:
6157:
6152:
6031:
6026:
6021:
6006:
5986:
5966:
5803:
5759:
5678:
3997:
3956:
3948:
3901:
3856:
3848:
3810:
3802:
3761:
3717:
3678:
3641:
3591:
3537:
3483:
3434:
3393:
3344:
3305:
3249:
3203:
3193:
3152:
3144:
3103:
3093:
3044:
2998:
2957:
2915:
2878:
2868:
2819:
2811:
2770:
2760:
2711:
2703:
2659:
2610:
2573:
2563:
2508:
2470:
2460:
2411:
2364:
2314:
2273:
2229:
2194:
2157:
2147:
1845:
1772:
908:
839:
783:
738:
6142:
6137:
6127:
6122:
6041:
5847:
4506:: Ptp1B R47C Modified at C47 with N--3-hydroxy-propionylamino}-ethyl)-phenyl]-oxalamic acid
3464:"Requirement for generation of H2O2 for platelet-derived growth factor signal transduction"
659:
6266:
6074:
1977:
1953:
1828:
1756:
883:
4896:: Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B
3789:
Lanahan AA, Lech D, Dubrac A, Zhang J, Zhuang ZW, Eichmann A, Simons M (September 2014).
3587:
3533:
3479:
3301:
3089:
2864:
2756:
2655:
2559:
2456:
2143:
6107:
5031:: Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase
3961:
3936:
3815:
3790:
3208:
3181:
3157:
3132:
2883:
2848:
1792:
1272:
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
30:
3806:
3254:
3237:
3108:
3073:
2824:
2799:
2416:
2369:
1381:
1376:
1371:
1366:
1361:
1356:
1351:
1346:
1341:
1336:
1331:
1326:
1321:
1316:
1311:
1306:
1301:
1296:
1291:
1286:
1281:
1276:
1271:
1266:
1261:
1256:
1251:
1246:
1230:
1225:
1220:
1215:
1210:
1205:
1200:
1195:
1190:
1185:
1180:
1164:
1159:
1154:
1149:
1144:
1139:
1134:
1129:
1124:
1119:
1114:
1109:
1104:
1099:
6286:
4731:: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE
3878:
2775:
2740:
2716:
2707:
2691:
2578:
2543:
2512:
2475:
2440:
2162:
2127:
2017:
2005:
1893:
1086:
3921:
3366:
3271:
2815:
2528:
2334:
1277:
negative regulation of vascular endothelial growth factor receptor signaling pathway
6099:
3611:
3557:
3503:
1812:
901:
680:
4002:
3985:
2919:
2663:
2396:
2349:
2278:
2261:
1840:
Cys215 residue, followed by subsequent protonation by Asp181 to yield the neutral
643:
3852:
3706:"Determinants of substrate recognition in the protein-tyrosine phosphatase, PTP1"
3487:
2233:
667:
6069:
2614:
2262:"Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer"
2113:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2095:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1897:
1824:
3349:
3332:
2397:"Characterization of the major protein-tyrosine-phosphatases of human placenta"
984:
2542:
Cicirelli MF, Tonks NK, Diltz CD, Weiel JE, Fischer EH, Krebs EG (July 1990).
2220:
Lessard L, Stuible M, Tremblay ML (2010). "The two faces of PTP1B in cancer".
2013:
1993:
1851:
1788:
800:
697:
647:
4881:: THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 11
4791:: A Highly Efficient Approach to a Selective and Cell Active PTP1B inhibitors
4521:: Crystal structure of the PTP1B complexed with SP7343-SP7964, a pTyr mimetic
3439:
3422:
3049:
3032:
5391:: The structure of phosphotyrosine phosphatase 1B in complex with compound 2
5376:: The structure of phosphotyrosine phosphatase 1B in complex with compound 2
4866:: THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 9
4851:: THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 6
4836:: THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 4
4821:: THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 3
4806:: THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 2
3722:
3705:
3704:
Zhang ZY, Walsh AB, Wu L, McNamara DJ, Dobrusin EM, Miller WT (March 1996).
3646:
3629:
3309:
3098:
2873:
2568:
2152:
1973:
1816:
1411:
1044:
922:
867:
854:
766:
753:
655:
4011:
3970:
3913:
3870:
3824:
3775:
3766:
3749:
3690:
3655:
3603:
3549:
3407:
3398:
3381:
3358:
3263:
3217:
3198:
3117:
3012:
3003:
2986:
2971:
2962:
2945:
2927:
2892:
2833:
2765:
2725:
2671:
2465:
2350:"Purification of the major protein-tyrosine-phosphatases of human placenta"
2326:
2287:
2241:
2206:
4671:: Crystal structure of the C215D mutant of protein tyrosine phosphatase 1B
3731:
3495:
3448:
3317:
3166:
3148:
3058:
2784:
2622:
2587:
2520:
2484:
2425:
2378:
2171:
1771:. PTP1B can dephosphorylate the phosphotyrosine residues of the activated
1721:
1716:
5537:
1938:
1841:
1705:
1556:
1537:
4446:: Structure of PTP1b in Complex with a Peptidic Bisphosphonate Inhibitor
3861:
3748:
Goldstein BJ, Bittner-Kowalczyk A, White MF, Harbeck M (February 2000).
3595:
3541:
3182:"PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446"
3952:
2847:
Heinonen KM, Dubé N, Bourdeau A, Lapp WS, Tremblay ML (February 2006).
1981:
1969:
1965:
1961:
1957:
1889:
1523:
1478:
5061:: STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS
5046:: STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS
3984:
Dubé N, Bourdeau A, Heinonen KM, Cheng A, Loy AL, Tremblay ML (2005).
3905:
3682:
2439:
Chernoff J, Schievella AR, Jost CA, Erikson RL, Neel BG (April 1990).
2198:
588:
584:
580:
576:
572:
568:
564:
560:
556:
552:
548:
544:
540:
536:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
416:
412:
408:
404:
400:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
352:
348:
344:
340:
336:
332:
328:
324:
320:
316:
312:
308:
304:
300:
296:
292:
288:
284:
280:
276:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
6236:
6231:
6226:
6172:
6162:
6036:
6016:
6011:
6001:
5996:
5991:
5971:
5935:
5930:
5914:
5909:
5904:
5857:
5852:
5774:
5769:
5764:
5754:
5749:
5744:
5739:
5734:
5673:
5638:
4551:: PTP1B WITH THE CATALYTIC CYSTEINE OXIDIZED TO A SULFENYL-AMIDE BOND
2798:
Buckley DA, Cheng A, Kiely PA, Tremblay ML, O'Connor R (April 2002).
1741:
1689:
1433:
3463:
1964:. PTPN1 knockout mice kept on high fat diets showed a resistance to
3462:
Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T (October 1995).
2318:
6221:
6147:
6132:
6117:
6112:
6089:
6046:
5961:
5940:
5842:
5837:
5832:
5827:
5822:
5817:
5812:
5729:
5724:
5719:
5714:
5709:
5704:
5699:
5668:
5663:
5658:
5653:
5648:
5643:
5633:
5628:
5623:
5618:
5613:
5608:
5603:
5598:
5593:
5588:
5583:
5578:
5421:: Crystal structure of PTP1B with a monocyclic thiophene inhibitor
4071:: PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL-PHOSPHATE INTERMEDIATE
2441:"Cloning of a cDNA for a major human protein-tyrosine-phosphatase"
1989:
1914:
1850:
1804:
4656:: Oxalyl-aryl-Amino Benzoic acid Inhibitors of PTP1B, compound 8b
4641:: Oxalyl-Aryl-Amino Benzoic Acid inhibitors of PTP1B, compound 17
2946:"TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B"
1831:(pTyr) substrate residue and the Phe182 residue on the WPD loop.
1396:
1392:
1292:
regulation of hepatocyte growth factor receptor signaling pathway
6271:
6261:
6256:
6203:
6079:
5888:
5883:
5878:
5436:: Crystal Structure of PTP1B with Monocyclic Thiophene Inhibitor
5406:: Crystal structure of PTP1B with monocyclic thiophene inhibitor
5016:: Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.
2016:
to the lung suggesting that PTPN1 may have an oncogenic role in
2009:
2001:
1926:
1922:
1808:
1796:
1752:
635:
5510:
5361:: Protein tyrosine phosphatase 1B with sulfamic acid inhibitors
5346:: Protein tyrosine phosphatase 1B with sulfamic acid inhibitors
5331:: Protein tyrosine phosphatase 1B with sulfamic acid inhibitors
5316:: Protein tyrosine phosphatase 1B with sulfamic acid inhibitors
5301:: Protein tyrosine phosphatase 1B with sulfamic acid inhibitors
5286:: Protein tyrosine phosphatase 1B with sulfamic acid inhibitors
5271:: Protein tyrosine phosphatase 1B with sulfamic acid inhibitors
4024:
5001:: Crystal structure of PTP1B with Bicyclic Thiophene inhibitor
4020:
3074:"The role of protein tyrosine phosphatase 1B in Ras signaling"
1997:
1803:
as well as other tyrosine-phosphorylated proteins, including
1367:
platelet-derived growth factor receptor-beta signaling pathway
1357:
negative regulation of PERK-mediated unfolded protein response
1312:
positive regulation of IRE1-mediated unfolded protein response
4566:: PTP1B WITH THE CATALYTIC CYSTEINE OXIDIZED TO SULFONIC ACID
5466:: CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B
5451:: CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B
4971:: PROTEIN TYROSINE PHOSPHATASE 1B WITH ACTIVE SITE INHIBITOR
4416:: Human Tyrosine Phosphatase 1B Complexed with an Inhibitor
4401:: Human Tyrosine Phosphatase 1B Complexed with an Inhibitor
4956:: Allosteric Inhibition of Protein Tyrosine Phosphatase 1B
4941:: Allosteric Inhibition of Protein Tyrosine Phosphatase 1B
4926:: Allosteric Inhibition of Protein Tyrosine Phosphatase 1B
1327:
regulation of type I interferon-mediated signaling pathway
4911:: 1.95 A structure of apo protein tyrosine phosphatase 1B
1317:
negative regulation of insulin receptor signaling pathway
5076:: STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (P212121)
3131:
Balsamo J, Arregui C, Leung T, Lilien J (October 1998).
891:
4386:: HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177836
4341:: HUMAN PTP1B CATALYTIC DOMAIN COMPLEXES WITH PNU179326
4326:: HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177496
3628:
Ravichandran LV, Chen H, Li Y, Quon MJ (October 2001).
2739:
Flint AJ, Tiganis T, Barford D, Tonks NK (March 1997).
1282:
positive regulation of protein tyrosine kinase activity
2985:
Zhang Z, Lin SY, Neel BG, Haimovich B (January 2006).
1267:
growth hormone receptor signaling pathway via JAK-STAT
4371:: CRYSTAL STRUCTURE OF APO HUMAN PTP1B (C215S) MUTANT
1056:
4626:: OXIDATION STATE OF PROTEIN TYROSINE PHOSPHATASE 1B
4611:: OXIDATION STATE OF PROTEIN TYROSINE PHOSPHATASE 1B
4596:: OXIDATION STATE OF PROTEIN TYROSINE PHOSPHATASE 1B
4581:: OXIDATION STATE OF PROTEIN TYROSINE PHOSPHATASE 1B
3380:
Mahadev K, Zilbering A, Zhu L, Goldstein BJ (2001).
1952:
PTP1B has clinical implications in the treatment of
6247:
6212:
6194:
6098:
6060:
5954:
5923:
5897:
5871:
5802:
5787:
5687:
5569:
5562:
5553:
5091:: STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (C2)
3333:"Protein tyrosine phosphatases in the human genome"
1650:
1625:
1599:
1574:
5256:: The structure of the S295F mutant of human PTP1B
2069:
2067:
2065:
2048:
2046:
2044:
1216:cytoplasmic side of endoplasmic reticulum membrane
4101:: HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
1855:Two step mechanism of PTP1B phosphatase activity.
1342:positive regulation of receptor catabolic process
838:
737:
4986:: PTP1B complexed with Isoxazole Carboxylic Acid
2636:
2634:
2632:
1734:Tyrosine-protein phosphatase non-receptor type 1
1362:regulation of insulin receptor signaling pathway
3743:
3741:
3623:
3621:
3569:
3567:
3515:
3513:
3238:"PTP1B: from the sidelines to the front lines!"
1827:interactions between the aromatic rings of the
1302:endoplasmic reticulum unfolded protein response
18:Protein-coding gene in the species Homo sapiens
5496:: Crystal Structure of PTP1B-inhibitor Complex
5481:: Crystal structure of PTP1B-inhibitor complex
3421:Lee SR, Kwon KS, Kim SR, Rhee SG (June 1998).
3283:
3281:
3072:Dubé N, Cheng A, Tremblay ML (February 2004).
2685:
2683:
2681:
2299:
2297:
2255:
2253:
2251:
2074:GRCm38: Ensembl release 89: ENSMUSG00000027540
1819:have also been described as PTP1B substrates.
5522:
4036:
3231:
3229:
3227:
2939:
2937:
1931:Vascular endothelial growth factor Receptor-2
1748:(PTP) family. In humans it is encoded by the
1307:regulation of intracellular protein transport
8:
3180:Stuible M, Dubé N, Tremblay ML (June 2008).
3031:Liu F, Hill DE, Chernoff J (December 1996).
2390:
2388:
1347:negative regulation of ERK1 and ERK2 cascade
3026:
3024:
3022:
2395:Tonks NK, Diltz CD, Fischer EH (May 1988).
2348:Tonks NK, Diltz CD, Fischer EH (May 1988).
2053:GRCh38: Ensembl release 89: ENSG00000196396
5799:
5566:
5559:
5529:
5515:
5507:
4043:
4029:
4021:
1407:
1377:negative regulation of signal transduction
1337:negative regulation of MAP kinase activity
1082:
879:
778:
675:
65:
4116:: CYCLIC PEPTIDE INHIBITOR OF HUMAN PTP1B
4001:
3960:
3860:
3814:
3765:
3721:
3645:
3438:
3397:
3348:
3253:
3207:
3197:
3156:
3107:
3097:
3048:
3002:
2961:
2882:
2872:
2823:
2774:
2764:
2715:
2577:
2567:
2474:
2464:
2415:
2368:
2277:
2161:
2151:
1892:signaling. The thiolate is oxidized to a
1297:response to endoplasmic reticulum stress
4058:
2040:
1322:IRE1-mediated unfolded protein response
20:
1781:insulin-like growth factor 1 receptor
1135:protein tyrosine phosphatase activity
843:
804:
799:
742:
701:
696:
7:
4131:: Human ptp1b complexed with tpicooh
1785:colony stimulating factor 1 receptor
1744:that is the founding member of the
1352:peptidyl-tyrosine dephosphorylation
1100:phosphoprotein phosphatase activity
1960:signalling and the development of
1935:Vascular endothelial growth factor
1647:
1622:
1596:
1571:
1547:
1528:
1502:
1483:
1457:
1438:
1257:insulin receptor signaling pathway
1061:
979:
917:
896:
14:
3807:10.1161/CIRCULATIONAHA.114.009683
1972:sensitivity as compared to their
1332:regulation of signal transduction
1252:actin cytoskeleton reorganization
5486:
5471:
5456:
5441:
5426:
5411:
5396:
5381:
5366:
5351:
5336:
5321:
5306:
5291:
5276:
5261:
5246:
5231:
5216:
5201:
5186:
5171:
5156:
5141:
5126:
5111:
5096:
5081:
5066:
5051:
5036:
5021:
5006:
4991:
4976:
4961:
4946:
4931:
4916:
4901:
4886:
4871:
4856:
4841:
4826:
4811:
4796:
4781:
4766:
4751:
4736:
4721:
4706:
4691:
4676:
4661:
4646:
4631:
4616:
4601:
4586:
4571:
4556:
4541:
4526:
4511:
4496:
4481:
4466:
4451:
4436:
4421:
4406:
4391:
4376:
4361:
4346:
4331:
4316:
4301:
4286:
4271:
4256:
4241:
4226:
4211:
4196:
4181:
4166:
4151:
4136:
4121:
4106:
4091:
4076:
4061:
2708:10.1128/MCB.20.15.5479-5489.2000
2260:Bentires-Alj M, Neel BG (2007).
1919:epidermal growth factor receptor
1777:epidermal growth factor receptor
1120:receptor tyrosine kinase binding
827:
820:
814:
791:
726:
719:
713:
688:
29:
2816:10.1128/MCB.22.7.1998-2010.2002
1738:protein-tyrosine phosphatase 1B
3841:Science Translational Medicine
1191:endoplasmic reticulum membrane
1140:protein phosphatase 2A binding
1045:More reference expression data
1:
5542:protein tyrosine phosphatases
4003:10.1158/0008-5472.CAN-05-1353
3255:10.1016/s0014-5793(03)00603-3
2920:10.1158/0008-5472.CAN-06-4338
2664:10.1126/science.283.5407.1544
2417:10.1016/S0021-9258(18)68703-4
2370:10.1016/S0021-9258(18)68702-2
2279:10.1158/0008-5472.CAN-06-4610
812:
711:
6293:Genes on human chromosome 20
3853:10.1126/scitranslmed.aar6294
3488:10.1126/science.270.5234.296
3078:Proc. Natl. Acad. Sci. U.S.A
2853:Proc. Natl. Acad. Sci. U.S.A
2745:Proc. Natl. Acad. Sci. U.S.A
2548:Proc. Natl. Acad. Sci. U.S.A
2513:10.1016/0092-8674(92)90190-N
2445:Proc. Natl. Acad. Sci. U.S.A
2234:10.1016/j.bbapap.2009.09.018
2030:Protein tyrosine phosphatase
1746:protein tyrosine phosphatase
2615:10.2337/diabetes.45.10.1379
1968:and an increased degree of
1884:), produced in response to
6309:
3350:10.1016/j.cell.2004.05.018
1231:protein-containing complex
4056:
2109:"Mouse PubMed Reference:"
2091:"Human PubMed Reference:"
1720:
1715:
1711:
1704:
1688:
1682:Chr 2: 167.77 – 167.82 Mb
1669:
1654:
1629:
1618:
1603:
1578:
1567:
1554:
1550:
1535:
1531:
1522:
1509:
1505:
1490:
1486:
1477:
1464:
1460:
1445:
1441:
1432:
1417:
1410:
1406:
1390:
1382:Unfolded Protein Response
1287:protein dephosphorylation
1247:regulation of endocytosis
1085:
1081:
1069:
1064:
1055:
1042:
991:
982:
929:
920:
890:
882:
878:
861:
848:
811:
790:
781:
777:
760:
747:
710:
687:
678:
674:
629:
626:
616:
609:
604:
73:
68:
51:
46:
41:
37:
28:
23:
3440:10.1074/jbc.273.25.15366
3236:Tonks NK (Jul 3, 2003).
3050:10.1074/jbc.271.49.31290
2008:cases. Murine models of
1909:PTPN1 has been shown to
1675:Chr 20: 50.51 – 50.59 Mb
1105:insulin receptor binding
1003:Rostral migratory stream
3723:10.1074/jbc.271.10.5386
3647:10.1210/mend.15.10.0711
3310:10.1126/science.8128219
3099:10.1073/pnas.0304242101
2874:10.1073/pnas.0508563103
2569:10.1073/pnas.87.14.5514
2153:10.1073/pnas.87.13.5148
1870:reactive oxygen species
1115:ephrin receptor binding
933:upper lobe of left lung
6061:Phosphatase and tensin
5688:Non receptor type PTPs
3767:10.1074/jbc.275.6.4283
3399:10.1074/jbc.C100109200
3199:10.1074/jbc.M710534200
3004:10.1074/jbc.M509590200
2963:10.1074/jbc.C100583200
2766:10.1073/pnas.94.5.1680
2466:10.1073/pnas.87.7.2735
2222:Biochim. Biophys. Acta
2132:Proc Natl Acad Sci USA
1856:
1763:Structure and function
1155:protein kinase binding
1011:mesenteric lymph nodes
3149:10.1083/jcb.143.2.523
1948:Clinical significance
1854:
1801:focal adhesion kinase
1769:endoplasmic reticulum
1211:endoplasmic reticulum
1015:stroma of bone marrow
704:Chromosome 20 (human)
1110:phosphatase activity
806:Chromosome 2 (mouse)
69:List of PDB id codes
42:Available structures
3596:10.1038/nature01681
3588:2003Natur.423..773V
3542:10.1038/nature01680
3534:2003Natur.423..769S
3480:1995Sci...270..296S
3302:1994Sci...263.1397B
3090:2004PNAS..101.1834D
2865:2006PNAS..103.2776H
2757:1997PNAS...94.1680F
2656:1999Sci...283.1544E
2560:1990PNAS...87.5514C
2457:1990PNAS...87.2735C
2144:1990PNAS...87.5148B
1226:cytoplasmic vesicle
5571:Receptor type PTPs
3953:10.1111/febs.12077
3296:(5152): 1397–404.
1857:
1512:ENSMUSG00000027540
1240:Biological process
1174:Cellular component
1150:hydrolase activity
1093:Molecular function
995:tibiofemoral joint
969:left adrenal gland
6280:
6279:
6190:
6189:
6186:
6185:
5804:MAPK phosphatases
5783:
5782:
5504:
5503:
3935:Tonks NK (2013).
3906:10.1002/med.20219
3847:(497): eaar6294.
3683:10.1021/bi000319w
2199:10.1021/jm901090b
1874:hydrogen peroxide
1731:
1730:
1727:
1726:
1700:
1699:
1665:
1664:
1644:
1643:
1614:
1613:
1593:
1592:
1563:
1562:
1544:
1543:
1518:
1517:
1499:
1498:
1473:
1472:
1454:
1453:
1402:
1401:
1372:dephosphorylation
1077:
1076:
1073:
1072:
1051:
1050:
1038:
1037:
1031:lactiferous gland
976:
975:
874:
873:
773:
772:
668:PTPN1 - orthologs
600:
599:
596:
595:
52:Ortholog search:
6300:
6063:homologs (PTENs)
5800:
5567:
5560:
5531:
5524:
5517:
5508:
5490:
5475:
5460:
5445:
5430:
5415:
5400:
5385:
5370:
5355:
5340:
5325:
5310:
5295:
5280:
5265:
5250:
5235:
5220:
5205:
5190:
5175:
5160:
5145:
5130:
5115:
5100:
5085:
5070:
5055:
5040:
5025:
5010:
4995:
4980:
4965:
4950:
4935:
4920:
4905:
4890:
4875:
4860:
4845:
4830:
4815:
4800:
4785:
4770:
4755:
4740:
4725:
4710:
4695:
4680:
4665:
4650:
4635:
4620:
4605:
4590:
4575:
4560:
4545:
4530:
4515:
4500:
4485:
4470:
4455:
4440:
4425:
4410:
4395:
4380:
4365:
4350:
4335:
4320:
4305:
4290:
4275:
4260:
4245:
4230:
4215:
4200:
4185:
4170:
4155:
4140:
4125:
4110:
4095:
4080:
4065:
4045:
4038:
4031:
4022:
4016:
4015:
4005:
3996:(21): 10088–95.
3981:
3975:
3974:
3964:
3932:
3926:
3925:
3889:
3883:
3882:
3864:
3835:
3829:
3828:
3818:
3786:
3780:
3779:
3769:
3745:
3736:
3735:
3725:
3701:
3695:
3694:
3666:
3660:
3659:
3649:
3625:
3616:
3615:
3571:
3562:
3561:
3528:(6941): 769–73.
3517:
3508:
3507:
3459:
3453:
3452:
3442:
3433:(25): 15366–72.
3418:
3412:
3411:
3401:
3392:(24): 21938–42.
3377:
3371:
3370:
3352:
3328:
3322:
3321:
3285:
3276:
3275:
3257:
3233:
3222:
3221:
3211:
3201:
3177:
3171:
3170:
3160:
3128:
3122:
3121:
3111:
3101:
3069:
3063:
3062:
3052:
3028:
3017:
3016:
3006:
2982:
2976:
2975:
2965:
2941:
2932:
2931:
2914:(21): 10129–37.
2903:
2897:
2896:
2886:
2876:
2844:
2838:
2837:
2827:
2810:(7): 1998–2010.
2795:
2789:
2788:
2778:
2768:
2736:
2730:
2729:
2719:
2687:
2676:
2675:
2650:(5407): 1544–8.
2638:
2627:
2626:
2598:
2592:
2591:
2581:
2571:
2539:
2533:
2532:
2495:
2489:
2488:
2478:
2468:
2436:
2430:
2429:
2419:
2401:
2392:
2383:
2382:
2372:
2354:
2345:
2339:
2338:
2301:
2292:
2291:
2281:
2257:
2246:
2245:
2217:
2211:
2210:
2182:
2176:
2175:
2165:
2155:
2123:
2117:
2116:
2105:
2099:
2098:
2087:
2081:
2071:
2060:
2050:
1846:hydrogen bonding
1773:insulin receptor
1713:
1712:
1684:
1677:
1660:
1648:
1639:
1623:
1619:RefSeq (protein)
1609:
1597:
1588:
1572:
1548:
1529:
1503:
1484:
1458:
1439:
1408:
1221:sorting endosome
1165:cadherin binding
1125:zinc ion binding
1083:
1062:
1047:
1023:Ileal epithelium
987:
985:Top expressed in
980:
925:
923:Top expressed in
918:
897:
880:
870:
857:
846:
831:
824:
818:
807:
795:
779:
769:
756:
745:
730:
723:
717:
706:
692:
676:
670:
621:
614:
591:
66:
60:
39:
38:
33:
21:
6308:
6307:
6303:
6302:
6301:
6299:
6298:
6297:
6283:
6282:
6281:
6276:
6243:
6208:
6182:
6094:
6062:
6056:
5950:
5919:
5893:
5867:
5795:
5792:
5789:
5779:
5683:
5549:
5535:
5505:
5500:
5497:
5491:
5482:
5476:
5467:
5461:
5452:
5446:
5437:
5431:
5422:
5416:
5407:
5401:
5392:
5386:
5377:
5371:
5362:
5356:
5347:
5341:
5332:
5326:
5317:
5311:
5302:
5296:
5287:
5281:
5272:
5266:
5257:
5251:
5242:
5236:
5227:
5221:
5212:
5206:
5197:
5191:
5182:
5176:
5167:
5161:
5152:
5146:
5137:
5131:
5122:
5116:
5107:
5101:
5092:
5086:
5077:
5071:
5062:
5056:
5047:
5041:
5032:
5026:
5017:
5011:
5002:
4996:
4987:
4981:
4972:
4966:
4957:
4951:
4942:
4936:
4927:
4921:
4912:
4906:
4897:
4891:
4882:
4876:
4867:
4861:
4852:
4846:
4837:
4831:
4822:
4816:
4807:
4801:
4792:
4786:
4777:
4771:
4762:
4756:
4747:
4741:
4732:
4726:
4717:
4711:
4702:
4696:
4687:
4681:
4672:
4666:
4657:
4651:
4642:
4636:
4627:
4621:
4612:
4606:
4597:
4591:
4582:
4576:
4567:
4561:
4552:
4546:
4537:
4531:
4522:
4516:
4507:
4501:
4492:
4486:
4477:
4471:
4462:
4456:
4447:
4441:
4432:
4426:
4417:
4411:
4402:
4396:
4387:
4381:
4372:
4366:
4357:
4351:
4342:
4336:
4327:
4321:
4312:
4306:
4297:
4291:
4282:
4276:
4267:
4261:
4252:
4246:
4237:
4231:
4222:
4216:
4207:
4201:
4192:
4186:
4177:
4171:
4162:
4156:
4147:
4141:
4132:
4126:
4117:
4111:
4102:
4096:
4087:
4081:
4072:
4066:
4052:
4049:
4019:
3983:
3982:
3978:
3934:
3933:
3929:
3891:
3890:
3886:
3837:
3836:
3832:
3788:
3787:
3783:
3747:
3746:
3739:
3716:(10): 5386–92.
3703:
3702:
3698:
3668:
3667:
3663:
3640:(10): 1768–80.
3634:Mol. Endocrinol
3627:
3626:
3619:
3582:(6941): 773–7.
3573:
3572:
3565:
3519:
3518:
3511:
3474:(5234): 296–9.
3461:
3460:
3456:
3420:
3419:
3415:
3379:
3378:
3374:
3330:
3329:
3325:
3287:
3286:
3279:
3235:
3234:
3225:
3192:(23): 15740–6.
3179:
3178:
3174:
3130:
3129:
3125:
3071:
3070:
3066:
3043:(49): 31290–5.
3030:
3029:
3020:
2984:
2983:
2979:
2956:(51): 47771–4.
2943:
2942:
2935:
2905:
2904:
2900:
2846:
2845:
2841:
2804:Mol. Cell. Biol
2797:
2796:
2792:
2738:
2737:
2733:
2702:(15): 5479–89.
2696:Mol. Cell. Biol
2689:
2688:
2679:
2640:
2639:
2630:
2609:(10): 1379–85.
2600:
2599:
2595:
2541:
2540:
2536:
2497:
2496:
2492:
2438:
2437:
2433:
2399:
2394:
2393:
2386:
2363:(14): 6722–30.
2352:
2347:
2346:
2342:
2303:
2302:
2295:
2259:
2258:
2249:
2219:
2218:
2214:
2184:
2183:
2179:
2138:(13): 5148–52.
2125:
2124:
2120:
2107:
2106:
2102:
2089:
2088:
2084:
2072:
2063:
2051:
2042:
2038:
2026:
1978:type 2 diabetes
1954:type 2 diabetes
1950:
1907:
1883:
1879:
1862:
1837:
1829:phosphotyrosine
1765:
1757:type 2 diabetes
1722:View/Edit Mouse
1717:View/Edit Human
1680:
1673:
1670:Location (UCSC)
1656:
1635:
1631:
1605:
1584:
1580:
1493:ENSG00000196396
1386:
1235:
1201:plasma membrane
1169:
1130:protein binding
1043:
1034:
1029:
1025:
1021:
1017:
1013:
1009:
1005:
1001:
997:
983:
972:
967:
965:ascending aorta
963:
961:tibial arteries
959:
955:
951:
947:
943:
939:
935:
921:
865:
852:
844:
834:
833:
832:
825:
805:
782:Gene location (
764:
751:
743:
733:
732:
731:
724:
702:
679:Gene location (
630:
617:
610:
75:
53:
19:
12:
11:
5:
6306:
6304:
6296:
6295:
6285:
6284:
6278:
6277:
6275:
6274:
6269:
6264:
6259:
6253:
6251:
6245:
6244:
6242:
6241:
6240:
6239:
6234:
6229:
6218:
6216:
6210:
6209:
6207:
6206:
6200:
6198:
6192:
6191:
6188:
6187:
6184:
6183:
6181:
6180:
6175:
6170:
6165:
6160:
6155:
6150:
6145:
6140:
6135:
6130:
6125:
6120:
6115:
6110:
6104:
6102:
6096:
6095:
6093:
6092:
6087:
6082:
6077:
6072:
6066:
6064:
6058:
6057:
6055:
6054:
6049:
6044:
6039:
6034:
6029:
6024:
6019:
6014:
6009:
6004:
5999:
5994:
5989:
5984:
5979:
5974:
5969:
5964:
5958:
5956:
5952:
5951:
5949:
5948:
5943:
5938:
5933:
5927:
5925:
5921:
5920:
5918:
5917:
5912:
5907:
5901:
5899:
5895:
5894:
5892:
5891:
5886:
5881:
5875:
5873:
5869:
5868:
5866:
5865:
5860:
5855:
5850:
5845:
5840:
5835:
5830:
5825:
5820:
5815:
5809:
5807:
5797:
5785:
5784:
5781:
5780:
5778:
5777:
5772:
5767:
5762:
5757:
5752:
5747:
5742:
5737:
5732:
5727:
5722:
5717:
5712:
5707:
5702:
5697:
5691:
5689:
5685:
5684:
5682:
5681:
5676:
5671:
5666:
5661:
5656:
5651:
5646:
5641:
5636:
5631:
5626:
5621:
5616:
5611:
5606:
5601:
5596:
5591:
5586:
5581:
5575:
5573:
5564:
5563:Classical PTPs
5557:
5551:
5550:
5536:
5534:
5533:
5526:
5519:
5511:
5502:
5501:
5499:
5498:
5492:
5485:
5483:
5477:
5470:
5468:
5462:
5455:
5453:
5447:
5440:
5438:
5432:
5425:
5423:
5417:
5410:
5408:
5402:
5395:
5393:
5387:
5380:
5378:
5372:
5365:
5363:
5357:
5350:
5348:
5342:
5335:
5333:
5327:
5320:
5318:
5312:
5305:
5303:
5297:
5290:
5288:
5282:
5275:
5273:
5267:
5260:
5258:
5252:
5245:
5243:
5237:
5230:
5228:
5222:
5215:
5213:
5207:
5200:
5198:
5192:
5185:
5183:
5177:
5170:
5168:
5162:
5155:
5153:
5147:
5140:
5138:
5132:
5125:
5123:
5117:
5110:
5108:
5102:
5095:
5093:
5087:
5080:
5078:
5072:
5065:
5063:
5057:
5050:
5048:
5042:
5035:
5033:
5027:
5020:
5018:
5012:
5005:
5003:
4997:
4990:
4988:
4982:
4975:
4973:
4967:
4960:
4958:
4952:
4945:
4943:
4937:
4930:
4928:
4922:
4915:
4913:
4907:
4900:
4898:
4892:
4885:
4883:
4877:
4870:
4868:
4862:
4855:
4853:
4847:
4840:
4838:
4832:
4825:
4823:
4817:
4810:
4808:
4802:
4795:
4793:
4787:
4780:
4778:
4772:
4765:
4763:
4757:
4750:
4748:
4742:
4735:
4733:
4727:
4720:
4718:
4712:
4705:
4703:
4697:
4690:
4688:
4682:
4675:
4673:
4667:
4660:
4658:
4652:
4645:
4643:
4637:
4630:
4628:
4622:
4615:
4613:
4607:
4600:
4598:
4592:
4585:
4583:
4577:
4570:
4568:
4562:
4555:
4553:
4547:
4540:
4538:
4532:
4525:
4523:
4517:
4510:
4508:
4502:
4495:
4493:
4487:
4480:
4478:
4472:
4465:
4463:
4457:
4450:
4448:
4442:
4435:
4433:
4427:
4420:
4418:
4412:
4405:
4403:
4397:
4390:
4388:
4382:
4375:
4373:
4367:
4360:
4358:
4352:
4345:
4343:
4337:
4330:
4328:
4322:
4315:
4313:
4307:
4300:
4298:
4292:
4285:
4283:
4277:
4270:
4268:
4262:
4255:
4253:
4247:
4240:
4238:
4232:
4225:
4223:
4217:
4210:
4208:
4202:
4195:
4193:
4187:
4180:
4178:
4172:
4165:
4163:
4157:
4150:
4148:
4142:
4135:
4133:
4127:
4120:
4118:
4112:
4105:
4103:
4097:
4090:
4088:
4082:
4075:
4073:
4067:
4060:
4057:
4054:
4053:
4050:
4048:
4047:
4040:
4033:
4025:
4018:
4017:
3976:
3927:
3900:(3): 459–517.
3884:
3830:
3781:
3737:
3696:
3677:(28): 8171–9.
3661:
3617:
3563:
3509:
3454:
3413:
3372:
3343:(6): 699–711.
3323:
3277:
3223:
3172:
3123:
3064:
3018:
2997:(3): 1746–54.
2977:
2933:
2898:
2859:(8): 2776–81.
2839:
2790:
2731:
2677:
2628:
2593:
2554:(14): 5514–8.
2534:
2490:
2431:
2410:(14): 6731–7.
2384:
2340:
2319:10.1038/ng1963
2293:
2247:
2212:
2193:(6): 2333–44.
2177:
2118:
2100:
2082:
2061:
2039:
2037:
2034:
2033:
2032:
2025:
2022:
1949:
1946:
1906:
1903:
1881:
1877:
1861:
1858:
1836:
1833:
1793:Janus kinase 2
1764:
1761:
1740:(PTP1B) is an
1736:also known as
1729:
1728:
1725:
1724:
1719:
1709:
1708:
1702:
1701:
1698:
1697:
1695:
1693:
1686:
1685:
1678:
1671:
1667:
1666:
1663:
1662:
1652:
1651:
1645:
1642:
1641:
1627:
1626:
1620:
1616:
1615:
1612:
1611:
1601:
1600:
1594:
1591:
1590:
1576:
1575:
1569:
1565:
1564:
1561:
1560:
1552:
1551:
1545:
1542:
1541:
1533:
1532:
1526:
1520:
1519:
1516:
1515:
1507:
1506:
1500:
1497:
1496:
1488:
1487:
1481:
1475:
1474:
1471:
1470:
1462:
1461:
1455:
1452:
1451:
1443:
1442:
1436:
1430:
1429:
1424:
1419:
1415:
1414:
1404:
1403:
1400:
1399:
1388:
1387:
1385:
1384:
1379:
1374:
1369:
1364:
1359:
1354:
1349:
1344:
1339:
1334:
1329:
1324:
1319:
1314:
1309:
1304:
1299:
1294:
1289:
1284:
1279:
1274:
1269:
1264:
1259:
1254:
1249:
1243:
1241:
1237:
1236:
1234:
1233:
1228:
1223:
1218:
1213:
1208:
1206:early endosome
1203:
1198:
1193:
1188:
1183:
1177:
1175:
1171:
1170:
1168:
1167:
1162:
1157:
1152:
1147:
1145:enzyme binding
1142:
1137:
1132:
1127:
1122:
1117:
1112:
1107:
1102:
1096:
1094:
1090:
1089:
1079:
1078:
1075:
1074:
1071:
1070:
1067:
1066:
1059:
1053:
1052:
1049:
1048:
1040:
1039:
1036:
1035:
1033:
1032:
1028:
1024:
1020:
1016:
1012:
1008:
1004:
1000:
999:corneal stroma
996:
992:
989:
988:
977:
974:
973:
971:
970:
966:
962:
958:
954:
950:
946:
942:
938:
934:
930:
927:
926:
914:
913:
905:
894:
888:
887:
884:RNA expression
876:
875:
872:
871:
863:
859:
858:
850:
847:
842:
836:
835:
826:
819:
813:
809:
808:
803:
797:
796:
788:
787:
775:
774:
771:
770:
762:
758:
757:
749:
746:
741:
735:
734:
725:
718:
712:
708:
707:
700:
694:
693:
685:
684:
672:
671:
628:
624:
623:
615:
607:
606:
602:
601:
598:
597:
594:
593:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
6305:
6294:
6291:
6290:
6288:
6273:
6270:
6268:
6265:
6263:
6260:
6258:
6255:
6254:
6252:
6250:
6246:
6238:
6235:
6233:
6230:
6228:
6225:
6224:
6223:
6220:
6219:
6217:
6215:
6211:
6205:
6202:
6201:
6199:
6197:
6193:
6179:
6176:
6174:
6171:
6169:
6166:
6164:
6161:
6159:
6156:
6154:
6151:
6149:
6146:
6144:
6141:
6139:
6136:
6134:
6131:
6129:
6126:
6124:
6121:
6119:
6116:
6114:
6111:
6109:
6106:
6105:
6103:
6101:
6100:Myotubularins
6097:
6091:
6088:
6086:
6083:
6081:
6078:
6076:
6073:
6071:
6068:
6067:
6065:
6059:
6053:
6050:
6048:
6045:
6043:
6040:
6038:
6035:
6033:
6030:
6028:
6025:
6023:
6020:
6018:
6015:
6013:
6010:
6008:
6005:
6003:
6000:
5998:
5995:
5993:
5990:
5988:
5985:
5983:
5980:
5978:
5975:
5973:
5970:
5968:
5965:
5963:
5960:
5959:
5957:
5955:Atypical DSPs
5953:
5947:
5944:
5942:
5939:
5937:
5934:
5932:
5929:
5928:
5926:
5922:
5916:
5913:
5911:
5908:
5906:
5903:
5902:
5900:
5896:
5890:
5887:
5885:
5882:
5880:
5877:
5876:
5874:
5870:
5864:
5861:
5859:
5856:
5854:
5851:
5849:
5846:
5844:
5841:
5839:
5836:
5834:
5831:
5829:
5826:
5824:
5821:
5819:
5816:
5814:
5811:
5810:
5808:
5805:
5801:
5798:
5794:
5791:dual specific
5786:
5776:
5773:
5771:
5768:
5766:
5763:
5761:
5758:
5756:
5753:
5751:
5748:
5746:
5743:
5741:
5738:
5736:
5733:
5731:
5728:
5726:
5723:
5721:
5718:
5716:
5713:
5711:
5708:
5706:
5703:
5701:
5698:
5696:
5693:
5692:
5690:
5686:
5680:
5677:
5675:
5672:
5670:
5667:
5665:
5662:
5660:
5657:
5655:
5652:
5650:
5647:
5645:
5642:
5640:
5637:
5635:
5632:
5630:
5627:
5625:
5622:
5620:
5617:
5615:
5612:
5610:
5607:
5605:
5602:
5600:
5597:
5595:
5592:
5590:
5587:
5585:
5582:
5580:
5577:
5576:
5574:
5572:
5568:
5565:
5561:
5558:
5556:
5552:
5547:
5543:
5539:
5532:
5527:
5525:
5520:
5518:
5513:
5512:
5509:
5495:
5489:
5484:
5480:
5474:
5469:
5465:
5459:
5454:
5450:
5444:
5439:
5435:
5429:
5424:
5420:
5414:
5409:
5405:
5399:
5394:
5390:
5384:
5379:
5375:
5369:
5364:
5360:
5354:
5349:
5345:
5339:
5334:
5330:
5324:
5319:
5315:
5309:
5304:
5300:
5294:
5289:
5285:
5279:
5274:
5270:
5264:
5259:
5255:
5249:
5244:
5240:
5234:
5229:
5225:
5219:
5214:
5210:
5204:
5199:
5195:
5189:
5184:
5180:
5174:
5169:
5165:
5159:
5154:
5150:
5144:
5139:
5135:
5129:
5124:
5120:
5114:
5109:
5105:
5099:
5094:
5090:
5084:
5079:
5075:
5069:
5064:
5060:
5054:
5049:
5045:
5039:
5034:
5030:
5024:
5019:
5015:
5009:
5004:
5000:
4994:
4989:
4985:
4979:
4974:
4970:
4964:
4959:
4955:
4949:
4944:
4940:
4934:
4929:
4925:
4919:
4914:
4910:
4904:
4899:
4895:
4889:
4884:
4880:
4874:
4869:
4865:
4859:
4854:
4850:
4844:
4839:
4835:
4829:
4824:
4820:
4814:
4809:
4805:
4799:
4794:
4790:
4784:
4779:
4775:
4769:
4764:
4760:
4754:
4749:
4745:
4739:
4734:
4730:
4724:
4719:
4715:
4709:
4704:
4700:
4694:
4689:
4685:
4679:
4674:
4670:
4664:
4659:
4655:
4649:
4644:
4640:
4634:
4629:
4625:
4619:
4614:
4610:
4604:
4599:
4595:
4589:
4584:
4580:
4574:
4569:
4565:
4559:
4554:
4550:
4544:
4539:
4535:
4529:
4524:
4520:
4514:
4509:
4505:
4499:
4494:
4490:
4484:
4479:
4475:
4469:
4464:
4460:
4454:
4449:
4445:
4439:
4434:
4430:
4424:
4419:
4415:
4409:
4404:
4400:
4394:
4389:
4385:
4379:
4374:
4370:
4364:
4359:
4355:
4349:
4344:
4340:
4334:
4329:
4325:
4319:
4314:
4310:
4304:
4299:
4295:
4289:
4284:
4280:
4274:
4269:
4265:
4259:
4254:
4250:
4244:
4239:
4235:
4229:
4224:
4220:
4214:
4209:
4205:
4199:
4194:
4190:
4184:
4179:
4175:
4169:
4164:
4160:
4154:
4149:
4145:
4139:
4134:
4130:
4124:
4119:
4115:
4109:
4104:
4100:
4094:
4089:
4085:
4079:
4074:
4070:
4064:
4059:
4055:
4046:
4041:
4039:
4034:
4032:
4027:
4026:
4023:
4013:
4009:
4004:
3999:
3995:
3991:
3987:
3980:
3977:
3972:
3968:
3963:
3958:
3954:
3950:
3947:(2): 346–78.
3946:
3942:
3938:
3931:
3928:
3923:
3919:
3915:
3911:
3907:
3903:
3899:
3895:
3888:
3885:
3880:
3876:
3872:
3868:
3863:
3858:
3854:
3850:
3846:
3842:
3834:
3831:
3826:
3822:
3817:
3812:
3808:
3804:
3801:(11): 902–9.
3800:
3796:
3792:
3785:
3782:
3777:
3773:
3768:
3763:
3760:(6): 4283–9.
3759:
3755:
3754:J. Biol. Chem
3751:
3744:
3742:
3738:
3733:
3729:
3724:
3719:
3715:
3711:
3710:J. Biol. Chem
3707:
3700:
3697:
3692:
3688:
3684:
3680:
3676:
3672:
3665:
3662:
3657:
3653:
3648:
3643:
3639:
3635:
3631:
3624:
3622:
3618:
3613:
3609:
3605:
3601:
3597:
3593:
3589:
3585:
3581:
3577:
3570:
3568:
3564:
3559:
3555:
3551:
3547:
3543:
3539:
3535:
3531:
3527:
3523:
3516:
3514:
3510:
3505:
3501:
3497:
3493:
3489:
3485:
3481:
3477:
3473:
3469:
3465:
3458:
3455:
3450:
3446:
3441:
3436:
3432:
3428:
3427:J. Biol. Chem
3424:
3417:
3414:
3409:
3405:
3400:
3395:
3391:
3387:
3386:J. Biol. Chem
3383:
3376:
3373:
3368:
3364:
3360:
3356:
3351:
3346:
3342:
3338:
3334:
3327:
3324:
3319:
3315:
3311:
3307:
3303:
3299:
3295:
3291:
3284:
3282:
3278:
3273:
3269:
3265:
3261:
3256:
3251:
3247:
3243:
3239:
3232:
3230:
3228:
3224:
3219:
3215:
3210:
3205:
3200:
3195:
3191:
3187:
3186:J. Biol. Chem
3183:
3176:
3173:
3168:
3164:
3159:
3154:
3150:
3146:
3143:(2): 523–32.
3142:
3138:
3134:
3127:
3124:
3119:
3115:
3110:
3105:
3100:
3095:
3091:
3087:
3084:(7): 1834–9.
3083:
3079:
3075:
3068:
3065:
3060:
3056:
3051:
3046:
3042:
3038:
3037:J. Biol. Chem
3034:
3027:
3025:
3023:
3019:
3014:
3010:
3005:
3000:
2996:
2992:
2991:J. Biol. Chem
2988:
2981:
2978:
2973:
2969:
2964:
2959:
2955:
2951:
2950:J. Biol. Chem
2947:
2940:
2938:
2934:
2929:
2925:
2921:
2917:
2913:
2909:
2902:
2899:
2894:
2890:
2885:
2880:
2875:
2870:
2866:
2862:
2858:
2854:
2850:
2843:
2840:
2835:
2831:
2826:
2821:
2817:
2813:
2809:
2805:
2801:
2794:
2791:
2786:
2782:
2777:
2772:
2767:
2762:
2758:
2754:
2751:(5): 1680–5.
2750:
2746:
2742:
2735:
2732:
2727:
2723:
2718:
2713:
2709:
2705:
2701:
2697:
2693:
2686:
2684:
2682:
2678:
2673:
2669:
2665:
2661:
2657:
2653:
2649:
2645:
2637:
2635:
2633:
2629:
2624:
2620:
2616:
2612:
2608:
2604:
2597:
2594:
2589:
2585:
2580:
2575:
2570:
2565:
2561:
2557:
2553:
2549:
2545:
2538:
2535:
2530:
2526:
2522:
2518:
2514:
2510:
2507:(3): 545–60.
2506:
2502:
2494:
2491:
2486:
2482:
2477:
2472:
2467:
2462:
2458:
2454:
2451:(7): 2735–9.
2450:
2446:
2442:
2435:
2432:
2427:
2423:
2418:
2413:
2409:
2405:
2404:J. Biol. Chem
2398:
2391:
2389:
2385:
2380:
2376:
2371:
2366:
2362:
2358:
2357:J. Biol. Chem
2351:
2344:
2341:
2336:
2332:
2328:
2324:
2320:
2316:
2313:(3): 338–46.
2312:
2308:
2300:
2298:
2294:
2289:
2285:
2280:
2275:
2272:(6): 2420–4.
2271:
2267:
2263:
2256:
2254:
2252:
2248:
2243:
2239:
2235:
2231:
2227:
2223:
2216:
2213:
2208:
2204:
2200:
2196:
2192:
2188:
2181:
2178:
2173:
2169:
2164:
2159:
2154:
2149:
2145:
2141:
2137:
2133:
2129:
2122:
2119:
2114:
2110:
2104:
2101:
2096:
2092:
2086:
2083:
2079:
2075:
2070:
2068:
2066:
2062:
2058:
2054:
2049:
2047:
2045:
2041:
2035:
2031:
2028:
2027:
2023:
2021:
2019:
2018:breast cancer
2015:
2011:
2007:
2006:breast cancer
2003:
1999:
1995:
1991:
1985:
1983:
1979:
1975:
1971:
1967:
1963:
1959:
1955:
1947:
1945:
1944:
1940:
1936:
1932:
1928:
1924:
1920:
1916:
1912:
1904:
1902:
1899:
1895:
1894:sulfenic acid
1891:
1887:
1875:
1871:
1867:
1859:
1853:
1849:
1847:
1843:
1834:
1832:
1830:
1826:
1820:
1818:
1814:
1810:
1806:
1802:
1798:
1794:
1790:
1786:
1782:
1778:
1774:
1770:
1762:
1760:
1758:
1754:
1751:
1747:
1743:
1739:
1735:
1723:
1718:
1714:
1710:
1707:
1703:
1696:
1694:
1691:
1687:
1683:
1679:
1676:
1672:
1668:
1661:
1659:
1653:
1649:
1646:
1640:
1638:
1634:
1628:
1624:
1621:
1617:
1610:
1608:
1602:
1598:
1595:
1589:
1587:
1583:
1577:
1573:
1570:
1568:RefSeq (mRNA)
1566:
1559:
1558:
1553:
1549:
1546:
1540:
1539:
1534:
1530:
1527:
1525:
1521:
1514:
1513:
1508:
1504:
1501:
1495:
1494:
1489:
1485:
1482:
1480:
1476:
1469:
1468:
1463:
1459:
1456:
1450:
1449:
1444:
1440:
1437:
1435:
1431:
1428:
1425:
1423:
1420:
1416:
1413:
1409:
1405:
1398:
1394:
1389:
1383:
1380:
1378:
1375:
1373:
1370:
1368:
1365:
1363:
1360:
1358:
1355:
1353:
1350:
1348:
1345:
1343:
1340:
1338:
1335:
1333:
1330:
1328:
1325:
1323:
1320:
1318:
1315:
1313:
1310:
1308:
1305:
1303:
1300:
1298:
1295:
1293:
1290:
1288:
1285:
1283:
1280:
1278:
1275:
1273:
1270:
1268:
1265:
1263:
1260:
1258:
1255:
1253:
1250:
1248:
1245:
1244:
1242:
1239:
1238:
1232:
1229:
1227:
1224:
1222:
1219:
1217:
1214:
1212:
1209:
1207:
1204:
1202:
1199:
1197:
1194:
1192:
1189:
1187:
1184:
1182:
1179:
1178:
1176:
1173:
1172:
1166:
1163:
1161:
1158:
1156:
1153:
1151:
1148:
1146:
1143:
1141:
1138:
1136:
1133:
1131:
1128:
1126:
1123:
1121:
1118:
1116:
1113:
1111:
1108:
1106:
1103:
1101:
1098:
1097:
1095:
1092:
1091:
1088:
1087:Gene ontology
1084:
1080:
1068:
1063:
1060:
1058:
1054:
1046:
1041:
1030:
1026:
1022:
1018:
1014:
1010:
1006:
1002:
998:
994:
993:
990:
986:
981:
978:
968:
964:
960:
956:
952:
948:
944:
940:
936:
932:
931:
928:
924:
919:
916:
915:
912:
910:
906:
904:
903:
899:
898:
895:
893:
889:
885:
881:
877:
869:
864:
860:
856:
851:
841:
837:
830:
823:
817:
810:
802:
798:
794:
789:
785:
780:
776:
768:
763:
759:
755:
750:
740:
736:
729:
722:
716:
709:
705:
699:
695:
691:
686:
682:
677:
673:
669:
665:
661:
657:
653:
649:
645:
641:
637:
633:
625:
620:
613:
608:
603:
592:
590:
586:
582:
578:
574:
570:
566:
562:
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
414:
410:
406:
402:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
354:
350:
346:
342:
338:
334:
330:
326:
322:
318:
314:
310:
306:
302:
298:
294:
290:
286:
282:
278:
274:
270:
266:
262:
258:
254:
250:
246:
242:
238:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
5793:phosphatases
5694:
5493:
5478:
5463:
5448:
5433:
5418:
5403:
5388:
5373:
5358:
5343:
5328:
5313:
5298:
5283:
5268:
5253:
5238:
5223:
5208:
5193:
5178:
5163:
5148:
5133:
5118:
5103:
5088:
5073:
5058:
5043:
5028:
5013:
4998:
4983:
4968:
4953:
4938:
4923:
4908:
4893:
4878:
4863:
4848:
4833:
4818:
4803:
4788:
4773:
4758:
4743:
4728:
4713:
4698:
4683:
4668:
4653:
4638:
4623:
4608:
4593:
4578:
4563:
4548:
4533:
4518:
4503:
4488:
4473:
4458:
4443:
4428:
4413:
4398:
4383:
4368:
4353:
4338:
4323:
4308:
4293:
4278:
4263:
4248:
4233:
4218:
4203:
4188:
4173:
4158:
4143:
4128:
4113:
4098:
4083:
4068:
3993:
3989:
3979:
3944:
3940:
3930:
3897:
3893:
3887:
3862:10609/103266
3844:
3840:
3833:
3798:
3794:
3784:
3757:
3753:
3713:
3709:
3699:
3674:
3671:Biochemistry
3670:
3664:
3637:
3633:
3579:
3575:
3525:
3521:
3471:
3467:
3457:
3430:
3426:
3416:
3389:
3385:
3375:
3340:
3336:
3326:
3293:
3289:
3248:(1): 140–8.
3245:
3242:FEBS Letters
3241:
3189:
3185:
3175:
3140:
3137:J. Cell Biol
3136:
3126:
3081:
3077:
3067:
3040:
3036:
2994:
2990:
2980:
2953:
2949:
2911:
2907:
2901:
2856:
2852:
2842:
2807:
2803:
2793:
2748:
2744:
2734:
2699:
2695:
2647:
2643:
2606:
2602:
2596:
2551:
2547:
2537:
2504:
2500:
2493:
2448:
2444:
2434:
2407:
2403:
2360:
2356:
2343:
2310:
2306:
2269:
2265:
2228:(3): 613–9.
2225:
2221:
2215:
2190:
2187:J. Med. Chem
2186:
2180:
2135:
2131:
2121:
2112:
2103:
2094:
2085:
1986:
1951:
1908:
1905:Interactions
1863:
1838:
1821:
1813:beta-catenin
1766:
1749:
1737:
1733:
1732:
1655:
1633:NP_001265547
1630:
1604:
1586:NM_001278618
1579:
1555:
1536:
1510:
1491:
1465:
1446:
1426:
1421:
907:
900:
866:167,821,305
853:167,773,977
627:External IDs
74:
15:
5788:VH1-like or
4051:PDB gallery
3894:Med Res Rev
3795:Circulation
1898:glutathione
1825:pi stacking
1160:RNA binding
1007:granulocyte
957:granulocyte
845:2|2 H3
765:50,585,241
752:50,510,321
605:Identifiers
5872:Slingshots
3990:Cancer Res
2908:Cancer Res
2307:Nat. Genet
2266:Cancer Res
2080:, May 2017
2059:, May 2017
2036:References
2014:metastases
1939:PGC1-alpha
1860:Regulation
953:lymph node
937:right lung
911:(ortholog)
648:HomoloGene
6214:Class III
5548:3.1.3.48)
3879:195188512
1974:wild-type
1943:ERR-alpha
1835:Mechanism
1817:cortactin
1658:NP_035331
1637:NP_002818
1607:NM_011201
1582:NM_002827
1412:Orthologs
1181:cytoplasm
656:GeneCards
6287:Category
6249:Class IV
6196:Class II
5538:Esterase
4012:16267035
3971:23176256
3922:23121386
3914:20814956
3871:31217339
3825:24982127
3776:10660596
3691:10889023
3656:11579209
3604:12802339
3550:12802338
3408:11297536
3367:18072568
3359:15186772
3272:21205538
3264:12829250
3218:18387954
3118:14766979
3013:16291744
2972:11694501
2928:17974954
2893:16477024
2834:11884589
2726:10891488
2672:10066179
2603:Diabetes
2529:43430621
2335:33612091
2327:17259984
2288:17347513
2242:19782770
2207:20000419
2076:–
2055:–
2024:See also
1911:interact
1842:tyrosine
1706:Wikidata
1391:Sources:
1196:membrane
949:monocyte
945:appendix
744:20q13.13
5982:DUSP13B
5977:DUSP13A
5946:PTP9Q22
5863:MK-STYX
5555:Class I
3962:3662559
3816:6060619
3732:8621392
3612:4424814
3584:Bibcode
3558:4416512
3530:Bibcode
3504:8065388
3496:7569979
3476:Bibcode
3468:Science
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3318:8128219
3298:Bibcode
3290:Science
3209:3259645
3167:9786960
3158:2132848
3086:Bibcode
3059:8940134
2884:1413784
2861:Bibcode
2785:9050838
2753:Bibcode
2652:Bibcode
2644:Science
2623:8826975
2588:2164686
2556:Bibcode
2521:1739967
2485:2157211
2453:Bibcode
2426:2834387
2379:2834386
2172:2164224
2140:Bibcode
2078:Ensembl
2057:Ensembl
1982:obesity
1970:insulin
1966:obesity
1962:obesity
1958:insulin
1890:insulin
1524:UniProt
1479:Ensembl
1418:Species
1397:QuickGO
1186:cytosol
1027:decidua
886:pattern
612:Aliases
6237:CDC25C
6232:CDC25B
6227:CDC25A
6178:MTMR15
6173:MTMR14
6168:MTMR13
6163:MTMR12
6158:MTMR11
6153:MTMR10
6037:DUSP27
6032:DUSP26
6027:DUSP25
6022:DUSP24
6017:DUSP23
6012:DUSP22
6007:DUSP21
6002:DUSP19
5997:DUSP18
5992:DUSP15
5987:DUSP14
5972:DUSP12
5967:DUSP11
5936:CDC14B
5931:CDC14A
5924:CDC14s
5915:PTP4A3
5910:PTP4A2
5905:PTP4A1
5858:DUSP16
5853:DUSP10
5806:(MKPs)
5796:(DSPs)
5775:PTPN23
5770:PTPN22
5765:PTPN21
5760:PTPN20
5755:PTPN18
5750:PTPN14
5745:PTPN13
5740:PTPN12
5735:PTPN11
5679:PTPRZ2
5674:PTPRZ1
5639:PTPRN2
4010:
3969:
3959:
3941:FEBS J
3920:
3912:
3877:
3869:
3823:
3813:
3774:
3730:
3689:
3654:
3610:
3602:
3576:Nature
3556:
3548:
3522:Nature
3502:
3494:
3447:
3406:
3365:
3357:
3316:
3270:
3262:
3216:
3206:
3165:
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3106:
3057:
3011:
2970:
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2832:
2825:133665
2822:
2783:
2773:
2724:
2714:
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2621:
2586:
2576:
2527:
2519:
2483:
2473:
2424:
2377:
2333:
2325:
2286:
2240:
2205:
2170:
2160:
1799:, and
1742:enzyme
1692:search
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1538:P18031
1434:Entrez
1057:BioGPS
1019:spleen
941:spleen
636:176885
6222:Cdc25
6148:MTMR9
6143:MTMR8
6138:MTMR7
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6128:MTMR5
6123:MTMR4
6118:MTMR3
6113:MTMR2
6090:TENC1
6047:RNGTT
6042:EMP2A
5962:DUSP3
5941:CDKN3
5848:DUSP9
5843:DUSP8
5838:DUSP7
5833:DUSP6
5828:DUSP5
5823:DUSP4
5818:DUSP2
5813:DUSP1
5730:PTPN9
5725:PTPN7
5720:PTPN6
5715:PTPN5
5710:PTPN4
5705:PTPN3
5700:PTPN2
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5664:PTPRT
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5649:PTPRQ
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5634:PTPRN
5629:PTPRM
5624:PTPRK
5619:PTPRJ
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5609:PTPRG
5604:PTPRF
5599:PTPRE
5594:PTPRD
5589:PTPRC
5584:PTPRB
5579:PTPRA
3918:S2CID
3875:S2CID
3608:S2CID
3554:S2CID
3500:S2CID
3363:S2CID
3268:S2CID
2776:19976
2717:85999
2579:54355
2525:S2CID
2476:53765
2400:(PDF)
2353:(PDF)
2331:S2CID
2163:54279
1990:HepG2
1915:BCAR1
1913:with
1805:BCAR1
1789:c-Src
1750:PTPN1
1467:19246
1427:Mouse
1422:Human
1393:Amigo
909:Mouse
902:Human
849:Start
784:Mouse
748:Start
681:Human
660:PTPN1
644:97805
619:PTPN1
24:PTPN1
6272:EYA4
6267:EYA3
6262:EYA2
6257:EYA1
6204:ACP1
6108:MTM1
6080:TPTE
6075:TPIP
6070:PTEN
6052:STYX
5898:PRLs
5889:SSH3
5884:SSH2
5879:SSH1
5494:2nta
5479:2nt7
5464:2hnq
5449:2hnp
5434:2hb1
5419:2h4k
5404:2h4g
5389:2fjn
5374:2fjm
5359:2f71
5344:2f70
5329:2f6z
5314:2f6y
5299:2f6w
5284:2f6v
5269:2f6t
5254:2f6f
5239:2cni
5224:2cnh
5209:2cng
5194:2cnf
5179:2cne
5164:2cmc
5149:2cmb
5134:2cma
5119:2cm8
5104:2cm7
5089:2cm3
5074:2cm2
5059:2bge
5044:2bgd
5029:2b4s
5014:2b07
4999:2azr
4984:1xbo
4969:1wax
4954:1t4j
4939:1t49
4924:1t48
4909:1sug
4894:1qxk
4879:1q6t
4864:1q6s
4849:1q6p
4834:1q6n
4819:1q6m
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4789:1q1m
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4759:1pxh
4744:1pty
4729:1ptv
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4669:1pa1
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4639:1ony
4624:1oev
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4594:1oet
4579:1oes
4564:1oeo
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4534:1nz7
4519:1nwl
4504:1nwe
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4219:1c88
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4069:1a5y
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3821:PMID
3772:PMID
3728:PMID
3687:PMID
3652:PMID
3600:PMID
3546:PMID
3492:PMID
3445:PMID
3404:PMID
3355:PMID
3337:Cell
3314:PMID
3260:PMID
3214:PMID
3163:PMID
3114:PMID
3055:PMID
3009:PMID
2968:PMID
2924:PMID
2889:PMID
2830:PMID
2781:PMID
2722:PMID
2668:PMID
2619:PMID
2584:PMID
2517:PMID
2501:Cell
2481:PMID
2422:PMID
2375:PMID
2323:PMID
2284:PMID
2238:PMID
2226:1804
2203:PMID
2168:PMID
2010:HER2
2002:HER2
1994:A431
1992:and
1980:and
1937:via
1933:and
1927:IRS1
1925:and
1923:Grb2
1888:and
1815:and
1809:DOK1
1797:TYK2
1753:gene
1448:5770
892:Bgee
840:Band
801:Chr.
739:Band
698:Chr.
652:2119
632:OMIM
589:4ZRT
585:4Y14
581:4QBW
577:4QBE
573:4QAP
569:4QAH
565:4I8N
561:4BJO
557:3ZV2
553:3ZMQ
549:3ZMP
545:3SME
541:3QKQ
537:3QKP
533:3I80
529:3I7Z
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521:3EB1
517:3EAX
513:3D9C
509:3CWE
505:3A5K
501:3A5J
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489:2VEY
485:2VEX
481:2VEW
477:2VEV
473:2VEU
469:2QBS
465:2QBR
461:2QBQ
457:2QBP
453:2NTA
449:2NT7
445:2HNQ
441:2HNP
437:2HB1
433:2H4K
429:2H4G
425:2FJN
421:2FJM
417:2F71
413:2F70
409:2F6Z
405:2F6Y
401:2F6W
397:2F6V
393:2F6T
389:2F6F
385:2CNI
381:2CNH
377:2CNG
373:2CNF
369:2CNE
365:2CMC
361:2CMB
357:2CMA
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345:2CM3
341:2CM2
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225:1ONY
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201:1NZ7
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193:1NWE
189:1NO6
185:1NNY
181:1NL9
177:1LQF
173:1L8G
169:1KAV
165:1KAK
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157:1I57
153:1GFY
149:1G7G
145:1G7F
141:1G1H
137:1G1G
133:1G1F
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121:1ECV
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113:1C87
109:1C86
105:1C85
101:1C84
97:1C83
93:1BZJ
89:1BZH
85:1BZC
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77:1A5Y
58:RCSB
55:PDBe
6085:TNS
3998:doi
3957:PMC
3949:doi
3945:280
3902:doi
3857:hdl
3849:doi
3811:PMC
3803:doi
3799:130
3762:doi
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3718:doi
3714:271
3679:doi
3642:doi
3592:doi
3580:423
3538:doi
3526:423
3484:doi
3472:270
3435:doi
3431:273
3394:doi
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3345:doi
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3306:doi
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3250:doi
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3204:PMC
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3153:PMC
3145:doi
3141:143
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3094:doi
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3045:doi
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2999:doi
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2916:doi
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2611:doi
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2408:263
2365:doi
2361:263
2315:doi
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2230:doi
2195:doi
2158:PMC
2148:doi
2004:in
1998:p53
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1065:n/a
862:End
761:End
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