373:
350:
247:
272:
2701:
638:
631:
624:
2686:
379:
278:
84:
25:
1469:, producing a massive protein with extracellular and cytoplasmic domains that are both unusually large. Exons 4, 5, and 6 (corresponding to protein regions A, B, and C) are alternatively spliced to generate up to eight different protein products featuring combinations of zero, one, two, or all three exons.
1608:
background to be a perfect congenic strain. This mouse, dubbed the CD45.1STEM mouse, differs from the C57BL/6 strain by a single base pair resulting in a single amino acid change that confers the difference in reactivity by the anti-CD45.1 and anti-CD45.2 antibodies. This strain was designed for
1491:
CD45R (also known as CD45RABC) contains all three possible exons. It is the longest protein and migrates at 200 kDa when isolated from T cells. B cells also express CD45R with heavier glycosylation, bringing the molecular weight to 220 kDa, hence the name B220 (B cell isoform of 220 kDa).
110:
1487:
Naive T lymphocytes are typically positive for CD45RA, which includes only the A protein region. Activated and memory T lymphocytes express CD45RO, the shortest CD45 isoform, which lacks all three of the A, B, and C regions. This shortest isoform facilitates T cell activation.
1588:
of CD45 in mice: CD45.1 (Ly5.1 historically) and CD45.2 (Ly5.2 historically). These two types of CD45 are believed to be functionally identical. As such, they are routinely used in scientific research to allow identification of cells. For instance,
1483:
CD45 isoforms show cell-type and differentiation-stage specific expression, a pattern which is quite well conserved in mammals. These isoforms are often used as markers that identify and distinguish between different types of immune cells.
2528:
Stanton T, Boxall S, Bennett A, Kaleebu P, Watera C, Whitworth J, et al. (May 2004). "CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive
Ugandans".
1359:, and other immune cells by modulating signaling pathways. It functions by dephosphorylating specific tyrosine residues on target proteins, thereby controlling various signaling processes essential for
1593:
can be transferred from a CD45.1 donor mouse, into a CD45.2 host mouse, and can be subsequently identified due to their expression of CD45.1. This technique is also routinely used when generating
3602:
4778:
2741:
1472:
CD45's large extracellular domain is highly glycosylated, and these eight isoforms allow wide variation in the structure of its side chains. The isoforms affect the protein's
2700:
43:
386:
285:
1343:
PTPRC is a critical enzyme involved in regulating immune cell function. PTPRC is a transmembrane protein tyrosine phosphatase expressed on the surface of all nucleated
1609:
competitive bone marrow transplantation assays and demonstrated perfect equivalence, unlike the previous standard, the "SJL" mouse, more formally known as Pep Boy.
1549:
CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis. CD45 does not colocalize with
1984:"Specific isoforms of the resident endoplasmic reticulum protein glucosidase II associate with the CD45 protein-tyrosine phosphatase via a lectin-like interaction"
3592:
2491:
Ishikawa H, Tsuyama N, Abroun S, Liu S, Li FJ, Otsuyama K, et al. (September 2003). "Interleukin-6, CD45 and the src-kinases in myeloma cell proliferation".
4771:
2342:
3572:
2685:
996:
977:
208:
4434:
2758:
2734:
1553:
on murine and human non-transformed hematopoietic cells, but CD45 positioning within lipid rafts is modified during their oncogenic transformation to
2394:"Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse"
1418:
signalling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain (a form of
1568:
the CD45 of healthy cells, among other cell markers, to be immune to a treatment that kills all normal CD45 cells, including the cancerous ones. An
4165:
1927:
1573:
4764:
4153:
3931:
4217:
4212:
4158:
3938:
2719:
2665:
1706:"Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain"
1686:
179:, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C
2238:"The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells"
1668:
1383:
cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic
5547:
5542:
3671:
3597:
2727:
1541:. In addition, CD45 was shown to be the target of the species D adenovirus 19a E3/49K protein to inhibit the activation of NK and T cells.
2025:"Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45"
107:
4700:
4695:
4690:
4685:
3612:
1572:
exists that kills specifically cells with unaltered CD45, and "shielded" cells with modified CD45 have been developed that evade this.
1244:
372:
1251:
4665:
1911:
61:
349:
3901:
1766:
1379:(PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
4469:
3963:
3649:
2367:
1655:
1634:
4108:
3644:
1576:
would be used to replace the original healthy blood cells with modified stem cells, and then the treatment would be applied.
1651:
1943:"Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II"
1465:
The CD45 protein family consists of multiple members that are all products of a single complex gene. This gene contains 34
271:
246:
4820:
4605:
4077:
4072:
4017:
3751:
3200:
1630:
5498:
5463:
5445:
5040:
4804:
4791:
4299:
4022:
1395:
1376:
188:
2596:
1569:
3617:
2289:"A unique secreted adenovirus E3 protein binds to the leukocyte common antigen CD45 and modulates leukocyte functions"
1501:
385:
284:
4329:
2754:
1329:
2066:"Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45"
1437:
Many alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
378:
277:
3195:
2658:
4795:
4379:
3274:
1045:
196:
4343:
1415:
1411:
1026:
1022:
2107:"CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line"
3686:
3681:
3676:
3666:
2973:
2901:
1783:
Hermiston ML, Xu Z, Weiss A (2003). "CD45: a critical regulator of signaling thresholds in immune cells".
1554:
1564:
Therapies for blood cancer, including acute myeloid leukemia, have been proposed based on the concept of
4756:
3030:
2948:
2566:
Huntington ND, Tarlinton DM (July 2004). "CD45: direct and indirect government of immune regulation".
4267:
3980:
2651:
1717:
1446:
1442:
260:
175:
4294:
4113:
1601:(Thy1) alleles, which CD90.1/CD90.2 system is used in the same manner as the CD45.1/CD45.2 system.
1565:
1223:
1219:
1182:
1152:
1148:
1115:
2236:
Gabaev I, Steinbrück L, Pokoyski C, Pich A, Stanton RJ, Schwinzer R, et al. (December 2011).
2148:"Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro"
1198:
1194:
5301:
3701:
3435:
2554:
2516:
2287:
Windheim M, Southcombe JH, Kremmer E, Chaplin L, Urlaub D, Falk CS, et al. (December 2013).
1594:
1344:
220:
5334:
1227:
1190:
1186:
1156:
1127:
1123:
1119:
2623:
2583:
2546:
2508:
2479:
2423:
2318:
2269:
2218:
2169:
2128:
2087:
2046:
2005:
1964:
1907:
1884:
1835:
1800:
1745:
1423:
1388:
637:
630:
168:
100:
5231:
5226:
5195:
5112:
1796:
1426:
required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses
5427:
5417:
5407:
5402:
5281:
5276:
5271:
5256:
5236:
5216:
5053:
5009:
4928:
4474:
4207:
4128:
3691:
2884:
2810:
2575:
2538:
2500:
2413:
2405:
2308:
2300:
2259:
2249:
2208:
2200:
2159:
2118:
2077:
2036:
1995:
1954:
1874:
1866:
1827:
1792:
1735:
1725:
1384:
465:
396:
340:
295:
5392:
5387:
5377:
5372:
5291:
5097:
2189:"SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription"
623:
216:
5516:
5324:
4534:
3070:
3065:
2988:
1477:
1360:
440:
1831:
1721:
5357:
4319:
3741:
3252:
3055:
2418:
2393:
2313:
2288:
2264:
2237:
1879:
1854:
1704:
Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, et al. (September 1990).
1419:
83:
2709:: Crystal structure of the tandem phosphatase domains of RPTP CD45 with a pTyr peptide
2213:
2188:
2123:
2106:
2082:
2065:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
709:
704:
699:
694:
689:
684:
679:
5536:
4289:
3746:
2837:
2632:
1870:
1740:
1705:
1399:
666:
2558:
2520:
2371:
2204:
5349:
4645:
3953:
3943:
3474:
3440:
1427:
1407:
1403:
458:
237:
200:
2409:
2254:
1445:
to differentiate between immune cell types, as well as to differentiate between
224:
5319:
4655:
4304:
4082:
4057:
3756:
3378:
3304:
2778:
2579:
2343:"Genetic cloaking of healthy cells opens door to universal blood cancer therapy"
2064:
Brown VK, Ogle EW, Burkhardt AL, Rowley RB, Bolen JB, Justement LB (June 1994).
2041:
2024:
1691:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1673:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1557:. CD45 colocalizes with lipid rafts on AML cells, which contributes to elevated
1364:
2293:
Proceedings of the
National Academy of Sciences of the United States of America
1710:
Proceedings of the
National Academy of Sciences of the United States of America
837:
negative regulation of cell adhesion involved in substrate-bound cell migration
541:
4585:
4309:
3990:
3731:
3607:
3240:
3235:
3230:
3085:
2869:
2542:
2504:
1590:
1550:
1473:
1438:
1348:
357:
254:
204:
1959:
1942:
4424:
4419:
4414:
4404:
4399:
4394:
4389:
2368:"JAX NOTES: Ly5 Gene Nomenclature, C57BL/6J and SJL/J - A History of Change"
2304:
1730:
1631:
ENSG00000262418 GRCh38: Ensembl release 89: ENSG00000081237, ENSG00000262418
1454:
941:
601:
479:
424:
411:
323:
310:
212:
2587:
2550:
2512:
2483:
2427:
2322:
2273:
2222:
2164:
2147:
2050:
2009:
2000:
1983:
1888:
1804:
2173:
2132:
2091:
1968:
1839:
1749:
1291:
1286:
4787:
4730:
4630:
4444:
4429:
3632:
3627:
3535:
3225:
1450:
1431:
1375:
The protein product of this gene, best known as CD45, is a member of the
1275:
1090:
1071:
4680:
4675:
4670:
4570:
4384:
4374:
4201:
4180:
4175:
4143:
3948:
3868:
3863:
3858:
3853:
3848:
3766:
3459:
3299:
3294:
3289:
3284:
3279:
2750:
2637:
2627:
1605:
1585:
1380:
1325:
1057:
1008:
145:
141:
137:
133:
129:
5486:
5481:
5476:
5422:
5412:
5286:
5266:
5261:
5251:
5246:
5241:
5221:
5185:
5180:
5164:
5159:
5154:
5107:
5102:
5024:
5019:
5014:
5004:
4999:
4994:
4989:
4984:
4923:
4888:
4620:
4580:
4565:
4549:
4544:
4524:
4519:
4454:
4262:
4232:
4196:
4187:
4000:
3968:
3832:
3827:
3797:
3776:
3736:
3696:
3562:
3540:
3499:
3423:
3418:
3413:
3408:
3403:
3398:
3267:
3262:
3257:
3205:
3190:
3060:
3050:
3013:
3008:
2926:
2921:
1558:
1538:
1356:
1352:
1311:
1259:
963:
2441:
1767:"Entrez Gene: PTPRC protein tyrosine phosphatase, receptor type, C"
5471:
5397:
5382:
5367:
5362:
5339:
5296:
5211:
5190:
5092:
5087:
5082:
5077:
5072:
5067:
5062:
4979:
4974:
4969:
4964:
4959:
4954:
4949:
4944:
4918:
4913:
4908:
4903:
4898:
4893:
4883:
4878:
4873:
4868:
4863:
4858:
4853:
4848:
4843:
4833:
4828:
4745:
4720:
4640:
4635:
4625:
4615:
4600:
4595:
4590:
4575:
4529:
4514:
4479:
4464:
4459:
4449:
4369:
4364:
4359:
4338:
4334:
4324:
4237:
4138:
4133:
4092:
4042:
4037:
4032:
4027:
4012:
4005:
3985:
3973:
3916:
3911:
3906:
3896:
3891:
3884:
3822:
3812:
3807:
3802:
3792:
3771:
3761:
3726:
3721:
3716:
3711:
3706:
3661:
3656:
3622:
3587:
3582:
3577:
3567:
3555:
3550:
3530:
3525:
3520:
3515:
3469:
3361:
3356:
3175:
3159:
3152:
3147:
3142:
3137:
3132:
3127:
3080:
3075:
2968:
2894:
2889:
2879:
1537:
UL11 protein. This interaction results in functional paralysis of
1526:
1508:
1466:
882:
positive regulation of antigen receptor-mediated signaling pathway
2694:: Crystal structure of the tandem phosphatase domain of RPTP CD45
926:
922:
5521:
5511:
5506:
5453:
5329:
5138:
5133:
5128:
4740:
4735:
4725:
4715:
4710:
4705:
4660:
4650:
4610:
4539:
4509:
4504:
4499:
4494:
4489:
4484:
4439:
4409:
4314:
4282:
4277:
4257:
4247:
4242:
4227:
4222:
4123:
4118:
4087:
4067:
4062:
4052:
4047:
3926:
3879:
3839:
3494:
3489:
3484:
3479:
3464:
3455:
3450:
3445:
3430:
3388:
3383:
3373:
3368:
3351:
3346:
3341:
3336:
3331:
3326:
3321:
3316:
3311:
3247:
3220:
3215:
3210:
3185:
3180:
3117:
3112:
3107:
3097:
3092:
3045:
3040:
3035:
3025:
3020:
3003:
2998:
2993:
2983:
2978:
2963:
2958:
2953:
2943:
2938:
2933:
2916:
2911:
2906:
2857:
2825:
2820:
2815:
2798:
2793:
2788:
2783:
1906:(2nd ed.). Greenwich Medical Media, Ltd. pp. 121–124.
1598:
1534:
1318:
192:
4760:
2723:
2647:
2470:
Tchilian EZ, Beverley PC (2002). "CD45 in memory and disease".
1476:
region, which extends linearly out from the cell and bears the
1351:. It plays a key role in the activation and differentiation of
646:
4252:
2864:
2852:
2847:
2842:
2832:
2805:
2773:
2643:
1561:
signal intensity involved in proliferation of leukemic cells.
1520:
1514:
18:
2622:
Overview of all the structural information available in the
695:
transmembrane receptor protein tyrosine phosphatase activity
1982:
Baldwin TA, Gogela-Spehar M, Ostergaard HL (October 2000).
1441:
against the different isoforms of CD45 are used in routine
1398:
that is present in various isoforms on all differentiated
822:
negative regulation of cytokine-mediated signaling pathway
1818:
Thomas ML (1989). "The leukocyte common antigen family".
2146:
Ng DH, Watts JD, Aebersold R, Johnson P (January 1996).
827:
positive regulation of hematopoietic stem cell migration
448:
1410:). CD45 has been shown to be an essential regulator of
39:
2636:(Receptor-type tyrosine-protein phosphatase C) at the
613:
5497:
5462:
5444:
5348:
5310:
5204:
5173:
5147:
5121:
5052:
5037:
4937:
4819:
4812:
4803:
4558:
4352:
4101:
3785:
3508:
3168:
2766:
1212:
1175:
1141:
1108:
842:
negative regulation of T cell mediated cytotoxicity
34:
may be too technical for most readers to understand
1647:
1645:
1643:
1626:
1624:
1622:
1604:In 2016 a new knock-in mouse was generated on the
1533:CD45 has been recently shown to interact with the
2472:Archivum Immunologiae Et Therapiae Experimentalis
2105:Koretzky GA, Kohmetscher M, Ross S (April 1993).
1928:"Mini-review: CD45 characterization and Isoforms"
395:
294:
1430:, and so functions as a negative regulator of
797:release of sequestered calcium ion into cytosol
2392:Mercier FE, Sykes DB, Scadden DT (June 2016).
1778:
1776:
1652:GRCm38: Ensembl release 89: ENSMUSG00000026395
1304:Protein tyrosine phosphatase, receptor type, C
902:positive regulation of protein kinase activity
892:positive regulation of stem cell proliferation
802:negative regulation of protein kinase activity
4772:
2735:
2659:
877:hematopoietic progenitor cell differentiation
8:
872:positive regulation of T cell proliferation
862:positive regulation of B cell proliferation
5049:
4816:
4809:
4779:
4765:
4757:
2742:
2728:
2720:
2666:
2652:
2644:
2023:Baldwin TA, Ostergaard HL (October 2001).
937:
662:
436:
335:
232:
118:
2759:list of human clusters of differentiation
2417:
2312:
2263:
2253:
2212:
2163:
2122:
2081:
2040:
1999:
1958:
1878:
1739:
1729:
62:Learn how and when to remove this message
46:, without removing the technical details.
2370:. The Jackson Laboratory. Archived from
1797:10.1146/annurev.immunol.21.120601.140946
1761:
1759:
2681:
1618:
1597:. An alternative system is the use of
847:cell surface receptor signaling pathway
16:Mammalian protein found in Homo sapiens
73:
2336:
2334:
2332:
1941:Arendt CW, Ostergaard HL (May 1997).
1902:Leong AS, Cooper K, Leong FJ (2003).
746:integral component of plasma membrane
710:protein tyrosine phosphatase activity
400:
361:
356:
299:
258:
253:
44:make it understandable to non-experts
7:
2601:Immunology course for undergraduates
1855:"CD45: all is not yet crystal clear"
2152:The Journal of Biological Chemistry
2111:The Journal of Biological Chemistry
2070:The Journal of Biological Chemistry
1988:The Journal of Biological Chemistry
1947:The Journal of Biological Chemistry
1832:10.1146/annurev.iy.07.040189.002011
1314:that, in humans, is encoded by the
907:peptidyl-tyrosine dephosphorylation
680:phosphoprotein phosphatase activity
2187:Wu L, Fu J, Shen SH (April 2002).
1209:
1172:
1138:
1105:
1081:
1062:
1036:
1013:
987:
968:
618:
536:
474:
453:
14:
2442:"002014 - B6.SJL-Ptprc Pepc/BoyJ"
887:T cell receptor signaling pathway
787:B cell receptor signaling pathway
2699:
2684:
1871:10.1111/j.1365-2567.2005.02265.x
766:external side of plasma membrane
636:
629:
622:
384:
377:
371:
348:
283:
276:
270:
245:
82:
23:
2205:10.1128/mcb.22.8.2673-2686.2002
1332:), which was originally called
2193:Molecular and Cellular Biology
726:integral component of membrane
647:More reference expression data
602:More reference expression data
1:
4792:protein tyrosine phosphatases
2124:10.1016/S0021-9258(18)52965-3
2083:10.1016/S0021-9258(17)32545-0
1904:Manual of Diagnostic Cytology
369:
268:
2410:10.1016/j.stemcr.2016.04.010
2255:10.1371/journal.ppat.1002432
1930:. Bio-Rad Laboratories, Inc.
1422:), or by activating various
1396:type I transmembrane protein
1377:protein tyrosine phosphatase
5548:Clusters of differentiation
5543:Genes on human chromosome 1
2755:clusters of differentiation
2580:10.1016/j.imlet.2004.05.011
2042:10.4049/jimmunol.167.7.3829
1820:Annual Review of Immunology
1785:Annual Review of Immunology
1584:There are two identifiable
1574:Blood stem cell transplants
792:cell cycle phase transition
5564:
1853:Holmes N (February 2006).
1387:, and thus belongs to the
1330:cluster of differentiation
1321:. PTPRC is also known as
771:secretory granule membrane
2679:
2543:10.1007/s00251-004-0668-z
2505:10.3109/10428190309178767
1687:"Mouse PubMed Reference:"
1669:"Human PubMed Reference:"
1290:
1285:
1281:
1274:
1258:
1245:Chr 1: 198.64 – 198.76 Mb
1239:
1216:
1179:
1168:
1145:
1112:
1101:
1088:
1084:
1069:
1065:
1056:
1043:
1039:
1020:
1016:
1007:
994:
990:
975:
971:
962:
947:
940:
936:
920:
867:defense response to virus
817:protein dephosphorylation
665:
661:
644:
621:
612:
599:
548:
539:
502:epithelium of nasopharynx
486:
477:
447:
439:
435:
418:
405:
368:
347:
338:
334:
317:
304:
267:
244:
235:
231:
186:
183:
173:
166:
161:
126:
121:
104:
99:
94:
90:
81:
76:
1960:10.1074/jbc.272.20.13117
1580:Use as a congenic marker
1500:PTPRC has been shown to
1334:leukocyte common antigen
1252:Chr 1: 137.99 – 138.1 Mb
912:neutrophil degranulation
832:regulation of cell cycle
2493:Leukemia & Lymphoma
2305:10.1073/pnas.1312420110
1731:10.1073/pnas.87.18.7000
1570:antibody-drug conjugate
1416:B-cell antigen receptor
807:bone marrow development
5311:Phosphatase and tensin
4938:Non receptor type PTPs
2165:10.1074/jbc.271.3.1295
2001:10.1074/jbc.M003088200
1555:acute myeloid leukemia
857:T cell differentiation
700:protein kinase binding
588:mesenteric lymph nodes
2366:Mobraaten LE (1994).
2341:Mole B (2024-07-15).
2029:Journal of Immunology
1566:genetically modifying
1447:histological sections
812:stem cell development
761:extracellular exosome
568:stroma of bone marrow
1443:immunohistochemistry
1434:receptor signaling.
852:B cell proliferation
685:phosphatase activity
402:1 E4|1 60.73 cM
363:Chromosome 1 (mouse)
261:Chromosome 1 (human)
122:List of PDB id codes
95:Available structures
2299:(50): E4884–E4893.
2076:(25): 17238–17244.
1994:(41): 32071–32076.
1953:(20): 13117–13125.
1722:1990PNAS...87.7000K
1545:Clinical importance
1345:hematopoietic cells
572:submandibular gland
4821:Receptor type PTPs
2603:. Davidson College
2595:Jameson R (2006).
2568:Immunology Letters
1424:Src family kinases
1046:ENSMUSG00000026395
780:Biological process
719:Cellular component
705:hydrolase activity
673:Molecular function
564:tibiofemoral joint
5530:
5529:
5440:
5439:
5436:
5435:
5054:MAPK phosphatases
5033:
5032:
4754:
4753:
2717:
2716:
2398:Stem Cell Reports
2117:(12): 8958–8964.
1716:(18): 7000–7004.
1389:receptor type PTP
1385:catalytic domains
1301:
1300:
1297:
1296:
1270:
1269:
1235:
1234:
1206:
1205:
1164:
1163:
1135:
1134:
1097:
1096:
1078:
1077:
1052:
1051:
1033:
1032:
1003:
1002:
984:
983:
932:
931:
897:dephosphorylation
657:
656:
653:
652:
608:
607:
595:
594:
533:
532:
518:bone marrow cells
431:
430:
330:
329:
225:PTPRC - orthologs
157:
156:
153:
152:
105:Ortholog search:
72:
71:
64:
5555:
5313:homologs (PTENs)
5050:
4817:
4810:
4781:
4774:
4767:
4758:
2744:
2737:
2730:
2721:
2703:
2688:
2668:
2661:
2654:
2645:
2611:
2609:
2608:
2591:
2562:
2524:
2499:(9): 1477–1481.
2487:
2456:
2455:
2453:
2452:
2438:
2432:
2431:
2421:
2389:
2383:
2382:
2380:
2379:
2363:
2357:
2356:
2354:
2353:
2338:
2327:
2326:
2316:
2284:
2278:
2277:
2267:
2257:
2248:(12): e1002432.
2233:
2227:
2226:
2216:
2199:(8): 2673–2686.
2184:
2178:
2177:
2167:
2158:(3): 1295–1300.
2143:
2137:
2136:
2126:
2102:
2096:
2095:
2085:
2061:
2055:
2054:
2044:
2035:(7): 3829–3835.
2020:
2014:
2013:
2003:
1979:
1973:
1972:
1962:
1938:
1932:
1931:
1924:
1918:
1917:
1899:
1893:
1892:
1882:
1850:
1844:
1843:
1815:
1809:
1808:
1780:
1771:
1770:
1763:
1754:
1753:
1743:
1733:
1701:
1695:
1694:
1683:
1677:
1676:
1665:
1659:
1649:
1638:
1628:
1283:
1282:
1254:
1247:
1230:
1210:
1201:
1173:
1169:RefSeq (protein)
1159:
1139:
1130:
1106:
1082:
1063:
1037:
1014:
988:
969:
938:
663:
649:
640:
633:
626:
619:
604:
544:
542:Top expressed in
537:
482:
480:Top expressed in
475:
454:
437:
427:
414:
403:
388:
381:
375:
364:
352:
336:
326:
313:
302:
287:
280:
274:
263:
249:
233:
227:
178:
171:
148:
119:
113:
92:
91:
86:
74:
67:
60:
56:
53:
47:
27:
26:
19:
5563:
5562:
5558:
5557:
5556:
5554:
5553:
5552:
5533:
5532:
5531:
5526:
5493:
5458:
5432:
5344:
5312:
5306:
5200:
5169:
5143:
5117:
5045:
5042:
5039:
5029:
4933:
4799:
4785:
4755:
4750:
4554:
4348:
4097:
3781:
3504:
3164:
2762:
2748:
2718:
2713:
2710:
2704:
2695:
2689:
2675:
2672:
2619:
2614:
2606:
2604:
2594:
2565:
2527:
2490:
2469:
2465:
2460:
2459:
2450:
2448:
2440:
2439:
2435:
2391:
2390:
2386:
2377:
2375:
2365:
2364:
2360:
2351:
2349:
2340:
2339:
2330:
2286:
2285:
2281:
2235:
2234:
2230:
2186:
2185:
2181:
2145:
2144:
2140:
2104:
2103:
2099:
2063:
2062:
2058:
2022:
2021:
2017:
1981:
1980:
1976:
1940:
1939:
1935:
1926:
1925:
1921:
1914:
1901:
1900:
1896:
1852:
1851:
1847:
1817:
1816:
1812:
1782:
1781:
1774:
1765:
1764:
1757:
1703:
1702:
1698:
1685:
1684:
1680:
1667:
1666:
1662:
1650:
1641:
1629:
1620:
1615:
1582:
1547:
1498:
1478:O-linked glycan
1463:
1373:
1361:immune response
1347:, particularly
1328:(CD stands for
1292:View/Edit Mouse
1287:View/Edit Human
1250:
1243:
1240:Location (UCSC)
1226:
1222:
1218:
1197:
1193:
1189:
1185:
1181:
1155:
1151:
1147:
1126:
1122:
1118:
1114:
1027:ENSG00000262418
1025:
1023:ENSG00000081237
916:
775:
741:plasma membrane
714:
690:protein binding
645:
635:
634:
628:
627:
600:
591:
586:
582:
578:
574:
570:
566:
562:
558:
554:
540:
529:
524:
520:
516:
512:
508:
504:
500:
496:
492:
478:
422:
409:
401:
391:
390:
389:
382:
362:
339:Gene location (
321:
308:
300:
290:
289:
288:
281:
259:
236:Gene location (
187:
174:
167:
128:
106:
68:
57:
51:
48:
40:help improve it
37:
28:
24:
17:
12:
11:
5:
5561:
5559:
5551:
5550:
5545:
5535:
5534:
5528:
5527:
5525:
5524:
5519:
5514:
5509:
5503:
5501:
5495:
5494:
5492:
5491:
5490:
5489:
5484:
5479:
5468:
5466:
5460:
5459:
5457:
5456:
5450:
5448:
5442:
5441:
5438:
5437:
5434:
5433:
5431:
5430:
5425:
5420:
5415:
5410:
5405:
5400:
5395:
5390:
5385:
5380:
5375:
5370:
5365:
5360:
5354:
5352:
5346:
5345:
5343:
5342:
5337:
5332:
5327:
5322:
5316:
5314:
5308:
5307:
5305:
5304:
5299:
5294:
5289:
5284:
5279:
5274:
5269:
5264:
5259:
5254:
5249:
5244:
5239:
5234:
5229:
5224:
5219:
5214:
5208:
5206:
5202:
5201:
5199:
5198:
5193:
5188:
5183:
5177:
5175:
5171:
5170:
5168:
5167:
5162:
5157:
5151:
5149:
5145:
5144:
5142:
5141:
5136:
5131:
5125:
5123:
5119:
5118:
5116:
5115:
5110:
5105:
5100:
5095:
5090:
5085:
5080:
5075:
5070:
5065:
5059:
5057:
5047:
5035:
5034:
5031:
5030:
5028:
5027:
5022:
5017:
5012:
5007:
5002:
4997:
4992:
4987:
4982:
4977:
4972:
4967:
4962:
4957:
4952:
4947:
4941:
4939:
4935:
4934:
4932:
4931:
4926:
4921:
4916:
4911:
4906:
4901:
4896:
4891:
4886:
4881:
4876:
4871:
4866:
4861:
4856:
4851:
4846:
4841:
4836:
4831:
4825:
4823:
4814:
4813:Classical PTPs
4807:
4801:
4800:
4786:
4784:
4783:
4776:
4769:
4761:
4752:
4751:
4749:
4748:
4743:
4738:
4733:
4728:
4723:
4718:
4713:
4708:
4703:
4698:
4693:
4688:
4683:
4678:
4673:
4668:
4663:
4658:
4653:
4648:
4643:
4638:
4633:
4628:
4623:
4618:
4613:
4608:
4603:
4598:
4593:
4588:
4583:
4578:
4573:
4568:
4562:
4560:
4556:
4555:
4553:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4497:
4492:
4487:
4482:
4477:
4472:
4467:
4462:
4457:
4452:
4447:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4387:
4382:
4377:
4372:
4367:
4362:
4356:
4354:
4350:
4349:
4347:
4346:
4341:
4332:
4327:
4322:
4317:
4312:
4307:
4302:
4297:
4292:
4287:
4286:
4285:
4280:
4270:
4265:
4260:
4255:
4250:
4245:
4240:
4235:
4230:
4225:
4220:
4215:
4210:
4205:
4199:
4190:
4185:
4184:
4183:
4178:
4168:
4163:
4162:
4161:
4156:
4146:
4141:
4136:
4131:
4126:
4121:
4116:
4111:
4105:
4103:
4099:
4098:
4096:
4095:
4090:
4085:
4080:
4075:
4070:
4065:
4060:
4055:
4050:
4045:
4040:
4035:
4030:
4025:
4020:
4015:
4010:
4009:
4008:
4003:
3993:
3988:
3983:
3978:
3977:
3976:
3971:
3966:
3956:
3951:
3946:
3941:
3936:
3935:
3934:
3929:
3919:
3914:
3909:
3904:
3899:
3894:
3889:
3888:
3887:
3882:
3872:
3866:
3861:
3856:
3851:
3842:
3837:
3836:
3835:
3830:
3825:
3815:
3810:
3805:
3800:
3795:
3789:
3787:
3783:
3782:
3780:
3779:
3774:
3769:
3764:
3759:
3754:
3749:
3744:
3739:
3734:
3729:
3724:
3719:
3714:
3709:
3704:
3699:
3694:
3689:
3684:
3679:
3674:
3669:
3664:
3659:
3654:
3653:
3652:
3647:
3637:
3636:
3635:
3630:
3620:
3615:
3610:
3605:
3600:
3595:
3590:
3585:
3580:
3575:
3570:
3565:
3560:
3559:
3558:
3553:
3543:
3538:
3533:
3528:
3523:
3518:
3512:
3510:
3506:
3505:
3503:
3502:
3497:
3492:
3487:
3482:
3477:
3472:
3467:
3462:
3453:
3448:
3443:
3438:
3433:
3428:
3427:
3426:
3421:
3416:
3411:
3406:
3401:
3391:
3386:
3381:
3376:
3371:
3366:
3365:
3364:
3359:
3349:
3344:
3339:
3334:
3329:
3324:
3319:
3314:
3309:
3308:
3307:
3302:
3297:
3292:
3287:
3282:
3272:
3271:
3270:
3265:
3260:
3250:
3245:
3244:
3243:
3238:
3233:
3223:
3218:
3213:
3208:
3203:
3198:
3193:
3188:
3183:
3178:
3172:
3170:
3166:
3165:
3163:
3162:
3157:
3156:
3155:
3150:
3145:
3140:
3135:
3130:
3120:
3115:
3110:
3105:
3100:
3095:
3090:
3089:
3088:
3083:
3078:
3073:
3063:
3058:
3053:
3048:
3043:
3038:
3033:
3028:
3023:
3018:
3017:
3016:
3011:
3001:
2996:
2991:
2986:
2981:
2976:
2971:
2966:
2961:
2956:
2951:
2946:
2941:
2936:
2931:
2930:
2929:
2924:
2914:
2909:
2904:
2899:
2898:
2897:
2892:
2887:
2882:
2872:
2867:
2862:
2861:
2860:
2850:
2845:
2840:
2835:
2830:
2829:
2828:
2823:
2818:
2808:
2803:
2802:
2801:
2796:
2791:
2786:
2781:
2770:
2768:
2764:
2763:
2749:
2747:
2746:
2739:
2732:
2724:
2715:
2714:
2712:
2711:
2705:
2698:
2696:
2690:
2683:
2680:
2677:
2676:
2673:
2671:
2670:
2663:
2656:
2648:
2642:
2641:
2618:
2617:External links
2615:
2613:
2612:
2592:
2574:(3): 167–174.
2563:
2537:(2): 107–110.
2531:Immunogenetics
2525:
2488:
2466:
2464:
2461:
2458:
2457:
2433:
2404:(6): 985–992.
2384:
2358:
2328:
2279:
2242:PLoS Pathogens
2228:
2179:
2138:
2097:
2056:
2015:
1974:
1933:
1919:
1912:
1894:
1865:(2): 145–155.
1845:
1810:
1772:
1755:
1696:
1678:
1660:
1639:
1617:
1616:
1614:
1611:
1581:
1578:
1546:
1543:
1531:
1530:
1524:
1518:
1512:
1497:
1494:
1462:
1459:
1420:co-stimulation
1402:cells (except
1372:
1369:
1306:also known as
1299:
1298:
1295:
1294:
1289:
1279:
1278:
1272:
1271:
1268:
1267:
1265:
1263:
1256:
1255:
1248:
1241:
1237:
1236:
1233:
1232:
1214:
1213:
1207:
1204:
1203:
1177:
1176:
1170:
1166:
1165:
1162:
1161:
1143:
1142:
1136:
1133:
1132:
1110:
1109:
1103:
1099:
1098:
1095:
1094:
1086:
1085:
1079:
1076:
1075:
1067:
1066:
1060:
1054:
1053:
1050:
1049:
1041:
1040:
1034:
1031:
1030:
1018:
1017:
1011:
1005:
1004:
1001:
1000:
992:
991:
985:
982:
981:
973:
972:
966:
960:
959:
954:
949:
945:
944:
934:
933:
930:
929:
918:
917:
915:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
783:
781:
777:
776:
774:
773:
768:
763:
758:
753:
748:
743:
738:
736:focal adhesion
733:
728:
722:
720:
716:
715:
713:
712:
707:
702:
697:
692:
687:
682:
676:
674:
670:
669:
659:
658:
655:
654:
651:
650:
642:
641:
616:
610:
609:
606:
605:
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585:
581:
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569:
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561:
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553:
549:
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534:
531:
530:
528:
527:
523:
519:
515:
511:
507:
503:
499:
495:
491:
487:
484:
483:
471:
470:
462:
451:
445:
444:
441:RNA expression
433:
432:
429:
428:
420:
416:
415:
407:
404:
399:
393:
392:
383:
376:
370:
366:
365:
360:
354:
353:
345:
344:
332:
331:
328:
327:
319:
315:
314:
306:
303:
298:
292:
291:
282:
275:
269:
265:
264:
257:
251:
250:
242:
241:
229:
228:
185:
181:
180:
172:
164:
163:
159:
158:
155:
154:
151:
150:
124:
123:
115:
114:
103:
97:
96:
88:
87:
79:
78:
70:
69:
31:
29:
22:
15:
13:
10:
9:
6:
4:
3:
2:
5560:
5549:
5546:
5544:
5541:
5540:
5538:
5523:
5520:
5518:
5515:
5513:
5510:
5508:
5505:
5504:
5502:
5500:
5496:
5488:
5485:
5483:
5480:
5478:
5475:
5474:
5473:
5470:
5469:
5467:
5465:
5461:
5455:
5452:
5451:
5449:
5447:
5443:
5429:
5426:
5424:
5421:
5419:
5416:
5414:
5411:
5409:
5406:
5404:
5401:
5399:
5396:
5394:
5391:
5389:
5386:
5384:
5381:
5379:
5376:
5374:
5371:
5369:
5366:
5364:
5361:
5359:
5356:
5355:
5353:
5351:
5350:Myotubularins
5347:
5341:
5338:
5336:
5333:
5331:
5328:
5326:
5323:
5321:
5318:
5317:
5315:
5309:
5303:
5300:
5298:
5295:
5293:
5290:
5288:
5285:
5283:
5280:
5278:
5275:
5273:
5270:
5268:
5265:
5263:
5260:
5258:
5255:
5253:
5250:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5218:
5215:
5213:
5210:
5209:
5207:
5205:Atypical DSPs
5203:
5197:
5194:
5192:
5189:
5187:
5184:
5182:
5179:
5178:
5176:
5172:
5166:
5163:
5161:
5158:
5156:
5153:
5152:
5150:
5146:
5140:
5137:
5135:
5132:
5130:
5127:
5126:
5124:
5120:
5114:
5111:
5109:
5106:
5104:
5101:
5099:
5096:
5094:
5091:
5089:
5086:
5084:
5081:
5079:
5076:
5074:
5071:
5069:
5066:
5064:
5061:
5060:
5058:
5055:
5051:
5048:
5044:
5041:dual specific
5036:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5008:
5006:
5003:
5001:
4998:
4996:
4993:
4991:
4988:
4986:
4983:
4981:
4978:
4976:
4973:
4971:
4968:
4966:
4963:
4961:
4958:
4956:
4953:
4951:
4948:
4946:
4943:
4942:
4940:
4936:
4930:
4927:
4925:
4922:
4920:
4917:
4915:
4912:
4910:
4907:
4905:
4902:
4900:
4897:
4895:
4892:
4890:
4887:
4885:
4882:
4880:
4877:
4875:
4872:
4870:
4867:
4865:
4862:
4860:
4857:
4855:
4852:
4850:
4847:
4845:
4842:
4840:
4837:
4835:
4832:
4830:
4827:
4826:
4824:
4822:
4818:
4815:
4811:
4808:
4806:
4802:
4797:
4793:
4789:
4782:
4777:
4775:
4770:
4768:
4763:
4762:
4759:
4747:
4744:
4742:
4739:
4737:
4734:
4732:
4729:
4727:
4724:
4722:
4719:
4717:
4714:
4712:
4709:
4707:
4704:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4682:
4679:
4677:
4674:
4672:
4669:
4667:
4664:
4662:
4659:
4657:
4654:
4652:
4649:
4647:
4644:
4642:
4639:
4637:
4634:
4632:
4629:
4627:
4624:
4622:
4619:
4617:
4614:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4563:
4561:
4557:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4386:
4383:
4381:
4378:
4376:
4373:
4371:
4368:
4366:
4363:
4361:
4358:
4357:
4355:
4351:
4345:
4342:
4340:
4336:
4333:
4331:
4328:
4326:
4323:
4321:
4318:
4316:
4313:
4311:
4308:
4306:
4303:
4301:
4298:
4296:
4293:
4291:
4288:
4284:
4281:
4279:
4276:
4275:
4274:
4271:
4269:
4266:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4214:
4211:
4209:
4206:
4203:
4200:
4198:
4194:
4191:
4189:
4186:
4182:
4179:
4177:
4174:
4173:
4172:
4169:
4167:
4164:
4160:
4157:
4155:
4152:
4151:
4150:
4147:
4145:
4142:
4140:
4137:
4135:
4132:
4130:
4127:
4125:
4122:
4120:
4117:
4115:
4112:
4110:
4107:
4106:
4104:
4100:
4094:
4091:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4054:
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4034:
4031:
4029:
4026:
4024:
4021:
4019:
4016:
4014:
4011:
4007:
4004:
4002:
3999:
3998:
3997:
3994:
3992:
3989:
3987:
3984:
3982:
3979:
3975:
3972:
3970:
3967:
3965:
3962:
3961:
3960:
3957:
3955:
3952:
3950:
3947:
3945:
3942:
3940:
3937:
3933:
3930:
3928:
3925:
3924:
3923:
3920:
3918:
3915:
3913:
3910:
3908:
3905:
3903:
3900:
3898:
3895:
3893:
3890:
3886:
3883:
3881:
3878:
3877:
3876:
3873:
3870:
3867:
3865:
3862:
3860:
3857:
3855:
3852:
3850:
3846:
3843:
3841:
3838:
3834:
3831:
3829:
3826:
3824:
3821:
3820:
3819:
3816:
3814:
3811:
3809:
3806:
3804:
3801:
3799:
3796:
3794:
3791:
3790:
3788:
3784:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3700:
3698:
3695:
3693:
3690:
3688:
3685:
3683:
3680:
3678:
3675:
3673:
3670:
3668:
3665:
3663:
3660:
3658:
3655:
3651:
3648:
3646:
3643:
3642:
3641:
3638:
3634:
3631:
3629:
3626:
3625:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3599:
3596:
3594:
3591:
3589:
3586:
3584:
3581:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3557:
3554:
3552:
3549:
3548:
3547:
3544:
3542:
3539:
3537:
3534:
3532:
3529:
3527:
3524:
3522:
3519:
3517:
3514:
3513:
3511:
3507:
3501:
3498:
3496:
3493:
3491:
3488:
3486:
3483:
3481:
3478:
3476:
3473:
3471:
3468:
3466:
3463:
3461:
3457:
3454:
3452:
3449:
3447:
3444:
3442:
3439:
3437:
3434:
3432:
3429:
3425:
3422:
3420:
3417:
3415:
3412:
3410:
3407:
3405:
3402:
3400:
3397:
3396:
3395:
3392:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3370:
3367:
3363:
3360:
3358:
3355:
3354:
3353:
3350:
3348:
3345:
3343:
3340:
3338:
3335:
3333:
3330:
3328:
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3306:
3303:
3301:
3298:
3296:
3293:
3291:
3288:
3286:
3283:
3281:
3278:
3277:
3276:
3273:
3269:
3266:
3264:
3261:
3259:
3256:
3255:
3254:
3251:
3249:
3246:
3242:
3239:
3237:
3234:
3232:
3229:
3228:
3227:
3224:
3222:
3219:
3217:
3214:
3212:
3209:
3207:
3204:
3202:
3199:
3197:
3194:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3173:
3171:
3167:
3161:
3158:
3154:
3151:
3149:
3146:
3144:
3141:
3139:
3136:
3134:
3131:
3129:
3126:
3125:
3124:
3121:
3119:
3116:
3114:
3111:
3109:
3106:
3104:
3101:
3099:
3096:
3094:
3091:
3087:
3084:
3082:
3079:
3077:
3074:
3072:
3069:
3068:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3037:
3034:
3032:
3029:
3027:
3024:
3022:
3019:
3015:
3012:
3010:
3007:
3006:
3005:
3002:
3000:
2997:
2995:
2992:
2990:
2987:
2985:
2982:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2928:
2925:
2923:
2920:
2919:
2918:
2915:
2913:
2910:
2908:
2905:
2903:
2900:
2896:
2893:
2891:
2888:
2886:
2883:
2881:
2878:
2877:
2876:
2873:
2871:
2868:
2866:
2863:
2859:
2856:
2855:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2834:
2831:
2827:
2824:
2822:
2819:
2817:
2814:
2813:
2812:
2809:
2807:
2804:
2800:
2797:
2795:
2792:
2790:
2787:
2785:
2782:
2780:
2777:
2776:
2775:
2772:
2771:
2769:
2765:
2760:
2756:
2752:
2745:
2740:
2738:
2733:
2731:
2726:
2725:
2722:
2708:
2702:
2697:
2693:
2687:
2682:
2678:
2669:
2664:
2662:
2657:
2655:
2650:
2649:
2646:
2639:
2635:
2634:
2629:
2625:
2621:
2620:
2616:
2602:
2598:
2593:
2589:
2585:
2581:
2577:
2573:
2569:
2564:
2560:
2556:
2552:
2548:
2544:
2540:
2536:
2532:
2526:
2522:
2518:
2514:
2510:
2506:
2502:
2498:
2494:
2489:
2485:
2481:
2477:
2473:
2468:
2467:
2462:
2447:
2443:
2437:
2434:
2429:
2425:
2420:
2415:
2411:
2407:
2403:
2399:
2395:
2388:
2385:
2374:on 2015-01-08
2373:
2369:
2362:
2359:
2348:
2344:
2337:
2335:
2333:
2329:
2324:
2320:
2315:
2310:
2306:
2302:
2298:
2294:
2290:
2283:
2280:
2275:
2271:
2266:
2261:
2256:
2251:
2247:
2243:
2239:
2232:
2229:
2224:
2220:
2215:
2210:
2206:
2202:
2198:
2194:
2190:
2183:
2180:
2175:
2171:
2166:
2161:
2157:
2153:
2149:
2142:
2139:
2134:
2130:
2125:
2120:
2116:
2112:
2108:
2101:
2098:
2093:
2089:
2084:
2079:
2075:
2071:
2067:
2060:
2057:
2052:
2048:
2043:
2038:
2034:
2030:
2026:
2019:
2016:
2011:
2007:
2002:
1997:
1993:
1989:
1985:
1978:
1975:
1970:
1966:
1961:
1956:
1952:
1948:
1944:
1937:
1934:
1929:
1923:
1920:
1915:
1913:1-84110-100-1
1909:
1905:
1898:
1895:
1890:
1886:
1881:
1876:
1872:
1868:
1864:
1860:
1856:
1849:
1846:
1841:
1837:
1833:
1829:
1825:
1821:
1814:
1811:
1806:
1802:
1798:
1794:
1790:
1786:
1779:
1777:
1773:
1768:
1762:
1760:
1756:
1751:
1747:
1742:
1737:
1732:
1727:
1723:
1719:
1715:
1711:
1707:
1700:
1697:
1692:
1688:
1682:
1679:
1674:
1670:
1664:
1661:
1657:
1653:
1648:
1646:
1644:
1640:
1636:
1632:
1627:
1625:
1623:
1619:
1612:
1610:
1607:
1602:
1600:
1596:
1592:
1587:
1579:
1577:
1575:
1571:
1567:
1562:
1560:
1556:
1552:
1544:
1542:
1540:
1536:
1528:
1525:
1522:
1519:
1516:
1513:
1510:
1507:
1506:
1505:
1503:
1495:
1493:
1489:
1485:
1481:
1479:
1475:
1470:
1468:
1460:
1458:
1456:
1452:
1448:
1444:
1440:
1435:
1433:
1429:
1425:
1421:
1417:
1413:
1409:
1405:
1401:
1400:hematopoietic
1397:
1392:
1390:
1386:
1382:
1378:
1370:
1368:
1366:
1362:
1358:
1354:
1350:
1346:
1341:
1339:
1335:
1331:
1327:
1324:
1320:
1317:
1313:
1309:
1305:
1293:
1288:
1284:
1280:
1277:
1273:
1266:
1264:
1261:
1257:
1253:
1249:
1246:
1242:
1238:
1231:
1229:
1225:
1221:
1215:
1211:
1208:
1202:
1200:
1196:
1192:
1188:
1184:
1178:
1174:
1171:
1167:
1160:
1158:
1154:
1150:
1144:
1140:
1137:
1131:
1129:
1125:
1121:
1117:
1111:
1107:
1104:
1102:RefSeq (mRNA)
1100:
1093:
1092:
1087:
1083:
1080:
1074:
1073:
1068:
1064:
1061:
1059:
1055:
1048:
1047:
1042:
1038:
1035:
1029:
1028:
1024:
1019:
1015:
1012:
1010:
1006:
999:
998:
993:
989:
986:
980:
979:
974:
970:
967:
965:
961:
958:
955:
953:
950:
946:
943:
939:
935:
928:
924:
919:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
784:
782:
779:
778:
772:
769:
767:
764:
762:
759:
757:
756:membrane raft
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
723:
721:
718:
717:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
677:
675:
672:
671:
668:
667:Gene ontology
664:
660:
648:
643:
639:
632:
625:
620:
617:
615:
611:
603:
598:
587:
583:
579:
575:
571:
567:
563:
559:
555:
551:
550:
547:
543:
538:
535:
525:
521:
517:
513:
509:
505:
501:
497:
493:
489:
488:
485:
481:
476:
473:
472:
469:
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149:
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125:
120:
117:
116:
112:
109:
102:
98:
93:
89:
85:
80:
75:
66:
63:
55:
45:
41:
35:
32:This article
30:
21:
20:
5043:phosphatases
4838:
4272:
4192:
4170:
4148:
3995:
3958:
3921:
3874:
3844:
3817:
3639:
3545:
3393:
3122:
3102:
2874:
2706:
2691:
2631:
2605:. Retrieved
2600:
2571:
2567:
2534:
2530:
2496:
2492:
2478:(2): 85–93.
2475:
2471:
2463:Bibliography
2449:. Retrieved
2445:
2436:
2401:
2397:
2387:
2376:. Retrieved
2372:the original
2361:
2350:. Retrieved
2347:Ars Technica
2346:
2296:
2292:
2282:
2245:
2241:
2231:
2196:
2192:
2182:
2155:
2151:
2141:
2114:
2110:
2100:
2073:
2069:
2059:
2032:
2028:
2018:
1991:
1987:
1977:
1950:
1946:
1936:
1922:
1903:
1897:
1862:
1858:
1848:
1823:
1819:
1813:
1788:
1784:
1713:
1709:
1699:
1690:
1681:
1672:
1663:
1603:
1583:
1563:
1548:
1532:
1499:
1496:Interactions
1490:
1486:
1482:
1471:
1464:
1436:
1408:plasma cells
1404:erythrocytes
1393:
1374:
1342:
1337:
1333:
1322:
1315:
1307:
1303:
1302:
1224:NP_001255215
1220:NP_001104786
1217:
1183:NP_001254727
1180:
1153:NM_001268286
1149:NM_001111316
1146:
1116:NM_001267798
1113:
1089:
1070:
1044:
1021:
995:
976:
956:
951:
751:cell surface
464:
457:
423:138,103,446
410:137,990,599
322:198,757,476
309:198,638,457
301:1q31.3-q32.1
184:External IDs
127:
58:
49:
33:
5038:VH1-like or
2674:PDB gallery
2446:www.jax.org
1791:: 107–137.
1551:lipid rafts
1428:JAK kinases
1365:homeostasis
1349:lymphocytes
1199:NP_002829.3
1195:NP_563578.2
584:Paneth cell
552:granulocyte
514:bone marrow
506:granulocyte
162:Identifiers
5537:Categories
5122:Slingshots
2757:(see also
2607:2011-10-24
2451:2020-10-11
2378:2015-01-08
2352:2024-07-15
1859:Immunology
1826:: 339–69.
1658:, May 2017
1637:, May 2017
1613:References
1591:leukocytes
1474:N-terminal
1455:carcinomas
1439:Antibodies
1394:CD45 is a
580:right lung
510:lymph node
468:(ortholog)
205:HomoloGene
5464:Class III
4798:3.1.3.48)
1480:chains.
1451:lymphomas
1228:NP_035340
1191:NP_563578
1187:NP_002829
1157:NM_011210
1128:NM_080922
1124:NM_080921
1120:NM_002838
942:Orthologs
213:GeneCards
52:July 2024
5499:Class IV
5446:Class II
4788:Esterase
2751:Proteins
2588:15275963
2559:10179258
2551:15057492
2521:19867177
2513:14565647
2484:12022705
2428:27185283
2323:24218549
2274:22174689
2223:11909961
2051:11564800
2010:10921916
1889:16423050
1805:12414720
1654:–
1633:–
1595:chimeras
1502:interact
1461:Isoforms
1432:cytokine
1391:family.
1371:Function
1276:Wikidata
921:Sources:
731:membrane
494:appendix
490:monocyte
5232:DUSP13B
5227:DUSP13A
5196:PTP9Q22
5113:MK-STYX
4805:Class I
4559:301–350
4353:251–300
4305:CD240CE
4102:201–250
3786:151–200
3509:101–150
2638:PDBe-KB
2628:UniProt
2419:4911492
2314:3864294
2265:3234252
2174:8576115
2133:8473339
2092:7516335
1969:9148925
1880:1782222
1840:2523715
1750:2169617
1718:Bibcode
1656:Ensembl
1635:Ensembl
1606:C57BL/6
1586:alleles
1539:T cells
1381:mitotic
1357:B cells
1353:T cells
1326:antigen
1058:UniProt
1009:Ensembl
948:Species
927:QuickGO
443:pattern
169:Aliases
38:Please
5487:CDC25C
5482:CDC25B
5477:CDC25A
5428:MTMR15
5423:MTMR14
5418:MTMR13
5413:MTMR12
5408:MTMR11
5403:MTMR10
5287:DUSP27
5282:DUSP26
5277:DUSP25
5272:DUSP24
5267:DUSP23
5262:DUSP22
5257:DUSP21
5252:DUSP19
5247:DUSP18
5242:DUSP15
5237:DUSP14
5222:DUSP12
5217:DUSP11
5186:CDC14B
5181:CDC14A
5174:CDC14s
5165:PTP4A3
5160:PTP4A2
5155:PTP4A1
5108:DUSP16
5103:DUSP10
5056:(MKPs)
5046:(DSPs)
5025:PTPN23
5020:PTPN22
5015:PTPN21
5010:PTPN20
5005:PTPN18
5000:PTPN14
4995:PTPN13
4990:PTPN12
4985:PTPN11
4929:PTPRZ2
4924:PTPRZ1
4889:PTPRN2
4566:CD300A
4525:CDw293
4310:CD240D
4171:CD213a
4149:CDw210
4114:CD202b
4088:CDw199
4083:CDw198
3737:CD140b
3169:51–100
2633:P08575
2597:"CD45"
2586:
2557:
2549:
2519:
2511:
2482:
2426:
2416:
2321:
2311:
2272:
2262:
2221:
2214:133720
2211:
2172:
2131:
2090:
2049:
2008:
1967:
1910:
1887:
1877:
1838:
1803:
1748:
1738:
1559:GM-CSF
1504:with:
1312:enzyme
1310:is an
1262:search
1260:PubMed
1091:P06800
1072:P08575
964:Entrez
614:BioGPS
560:thymus
556:spleen
526:spleen
522:thymus
193:151460
5472:Cdc25
5398:MTMR9
5393:MTMR8
5388:MTMR7
5383:MTMR6
5378:MTMR5
5373:MTMR4
5368:MTMR3
5363:MTMR2
5340:TENC1
5297:RNGTT
5292:EMP2A
5212:DUSP3
5191:CDKN3
5098:DUSP9
5093:DUSP8
5088:DUSP7
5083:DUSP6
5078:DUSP5
5073:DUSP4
5068:DUSP2
5063:DUSP1
4980:PTPN9
4975:PTPN7
4970:PTPN6
4965:PTPN5
4960:PTPN4
4955:PTPN3
4950:PTPN2
4945:PTPN1
4919:PTPRU
4914:PTPRT
4909:PTPRS
4904:PTPRR
4899:PTPRQ
4894:PTPRO
4884:PTPRN
4879:PTPRM
4874:PTPRK
4869:PTPRJ
4864:PTPRH
4859:PTPRG
4854:PTPRF
4849:PTPRE
4844:PTPRD
4839:PTPRC
4834:PTPRB
4829:PTPRA
4746:CD350
4741:CD349
4736:CD344
4731:CD340
4726:CD339
4721:CD338
4716:CD337
4711:CD336
4706:CD335
4701:CD334
4696:CD333
4691:CD332
4686:CD331
4681:CD329
4676:CD328
4671:CD327
4666:CD326
4661:CD325
4656:CD324
4651:CD322
4646:CD321
4641:CD320
4636:CD318
4631:CD317
4626:CD316
4621:CD315
4616:CD314
4611:CD312
4606:CD309
4601:CD307
4596:CD306
4591:CD305
4586:CD304
4581:CD303
4576:CD302
4571:CD301
4550:CD299
4545:CD298
4540:CD297
4535:CD295
4530:CD294
4520:CD292
4515:CD290
4510:CD289
4505:CD288
4500:CD286
4495:CD284
4490:CD283
4485:CD282
4480:CD281
4475:CD280
4470:CD279
4465:CD278
4460:CD276
4455:CD275
4450:CD274
4445:CD273
4440:CD272
4435:CD271
4430:CD269
4425:CD268
4420:CD267
4415:CD266
4410:CD265
4405:CD264
4400:CD263
4395:CD262
4390:CD261
4385:CD258
4380:CD257
4375:CD256
4370:CD254
4365:CD253
4360:CD252
4344:CD249
4339:CD248
4335:CD247
4330:CD246
4325:CD244
4320:CD243
4315:CD241
4300:CD239
4295:CD238
4290:CD236
4273:CD235
4268:CD234
4263:CD233
4258:CD230
4253:CD229
4248:CD228
4243:CD227
4238:CD226
4233:CD225
4228:CD224
4223:CD223
4218:CD222
4213:CD221
4208:CD220
4193:CD218
4188:CD217
4166:CD212
4144:CD209
4139:CD208
4134:CD207
4129:CD206
4124:CD205
4119:CD204
4109:CD201
4093:CD200
4078:CD197
4073:CD196
4068:CD195
4063:CD194
4058:CD193
4053:CD192
4048:CD191
4043:CD186
4038:CD185
4033:CD184
4028:CD183
4023:CD182
4018:CD181
4013:CD180
3996:CD179
3991:CD178
3986:CD177
3981:CD174
3959:CD172
3954:CD171
3949:CD170
3944:CD169
3939:CD168
3922:CD167
3917:CD166
3912:CD164
3907:CD163
3902:CD162
3897:CD161
3892:CD160
3875:CD159
3845:CD158
3840:CD157
3818:CD156
3813:CD155
3808:CD154
3803:CD153
3798:CD152
3793:CD151
3777:CD150
3772:CD148
3767:CD147
3762:CD146
3757:CD144
3752:CD143
3747:CD142
3742:CD141
3732:CD138
3727:CD137
3722:CD136
3717:CD135
3712:CD134
3707:CD133
3702:CD132
3697:CD131
3692:CD130
3687:CD129
3682:CD127
3677:CD126
3672:CD125
3667:CD124
3662:CD123
3657:CD122
3640:CD121
3623:CD120
3618:CD119
3613:CD118
3608:CD117
3603:CD116
3598:CD115
3593:CD114
3588:CD113
3583:CD112
3578:CD111
3573:CD110
3568:CD109
3563:CD108
3546:CD107
3541:CD106
3536:CD105
3531:CD104
3526:CD103
3521:CD102
3516:CD101
3500:CD100
2555:S2CID
2517:S2CID
1741:54670
1527:SKAP1
1523:, and
1509:GANAB
1467:exons
1449:from
1316:PTPRC
1308:PTPRC
997:19264
957:Mouse
952:Human
923:Amigo
576:blood
498:blood
466:Mouse
459:Human
406:Start
341:Mouse
305:Start
238:Human
217:PTPRC
201:97810
176:PTPRC
77:PTPRC
5522:EYA4
5517:EYA3
5512:EYA2
5507:EYA1
5454:ACP1
5358:MTM1
5330:TPTE
5325:TPIP
5320:PTEN
5302:STYX
5148:PRLs
5139:SSH3
5134:SSH2
5129:SSH1
3495:CD99
3490:CD98
3485:CD97
3480:CD96
3475:CD95
3470:CD94
3465:CD93
3460:CD92
3456:CD91
3451:CD90
3446:CD89
3441:CD88
3436:CD87
3431:CD86
3394:CD85
3389:CD84
3384:CD83
3379:CD82
3374:CD81
3369:CD80
3352:CD79
3347:CD78
3342:CD74
3337:CD73
3332:CD72
3327:CD71
3322:CD70
3317:CD69
3312:CD68
3275:CD66
3253:CD64
3248:CD63
3226:CD62
3221:CD61
3216:CD59
3211:CD58
3206:CD57
3201:CD56
3196:CD55
3191:CD54
3186:CD53
3181:CD52
3176:CD51
3160:CD50
3123:CD49
3118:CD48
3113:CD47
3108:CD46
3103:CD45
3098:CD44
3093:CD43
3066:CD42
3061:CD41
3056:CD40
3051:CD39
3046:CD38
3041:CD37
3036:CD36
3031:CD35
3026:CD34
3021:CD33
3004:CD32
2999:CD31
2994:CD30
2989:CD29
2984:CD28
2979:CD27
2974:CD26
2969:CD25
2964:CD24
2959:CD23
2954:CD22
2949:CD21
2944:CD20
2939:CD19
2934:CD18
2917:CD16
2912:CD15
2907:CD14
2902:CD13
2875:CD11
2870:CD10
2767:1–50
2707:1ygu
2692:1ygr
2626:for
2584:PMID
2547:PMID
2509:PMID
2480:PMID
2424:PMID
2319:PMID
2270:PMID
2219:PMID
2170:PMID
2129:PMID
2088:PMID
2047:PMID
2006:PMID
1965:PMID
1908:ISBN
1885:PMID
1836:PMID
1801:PMID
1746:PMID
1599:CD90
1535:HCMV
1453:and
1414:and
1406:and
1363:and
1323:CD45
1319:gene
978:5788
449:Bgee
397:Band
358:Chr.
296:Band
255:Chr.
209:2126
189:OMIM
146:5FN7
142:5FN6
138:5FMV
134:1YGR
130:1YGU
111:RCSB
108:PDBe
5335:TNS
2865:CD9
2853:CD8
2848:CD7
2843:CD6
2838:CD5
2833:CD4
2811:CD3
2806:CD2
2779:a-c
2774:CD1
2624:PDB
2576:doi
2539:doi
2501:doi
2414:PMC
2406:doi
2309:PMC
2301:doi
2297:110
2260:PMC
2250:doi
2209:PMC
2201:doi
2160:doi
2156:271
2119:doi
2115:268
2078:doi
2074:269
2037:doi
2033:167
1996:doi
1992:275
1955:doi
1951:272
1875:PMC
1867:doi
1863:117
1828:doi
1793:doi
1736:PMC
1726:doi
1521:Lck
1515:LYN
1340:).
1338:LCA
419:End
318:End
221:OMA
197:MGI
101:PDB
42:to
5539::
4796:EC
4790::
4337:-
3458:-
2799:1E
2794:1D
2789:1B
2784:1A
2753::
2630::
2599:.
2582:.
2572:94
2570:.
2553:.
2545:.
2535:56
2533:.
2515:.
2507:.
2497:44
2495:.
2476:50
2474:.
2444:.
2422:.
2412:.
2400:.
2396:.
2345:.
2331:^
2317:.
2307:.
2295:.
2291:.
2268:.
2258:.
2244:.
2240:.
2217:.
2207:.
2197:22
2195:.
2191:.
2168:.
2154:.
2150:.
2127:.
2113:.
2109:.
2086:.
2072:.
2068:.
2045:.
2031:.
2027:.
2004:.
1990:.
1986:.
1963:.
1949:.
1945:.
1883:.
1873:.
1861:.
1857:.
1834:.
1822:.
1799:.
1789:21
1787:.
1775:^
1758:^
1744:.
1734:.
1724:.
1714:87
1712:.
1708:.
1689:.
1671:.
1642:^
1621:^
1457:.
1412:T-
1367:.
1355:,
925:/
425:bp
412:bp
324:bp
311:bp
219:;
215::
211:;
207::
203:;
199::
195:;
191::
144:,
140:,
136:,
132:,
4794:(
4780:e
4773:t
4766:v
4283:b
4278:a
4204:)
4202:b
4197:a
4195:(
4181:2
4176:1
4159:b
4154:a
4006:b
4001:a
3974:g
3969:b
3964:a
3932:b
3927:a
3885:c
3880:a
3871:)
3869:k
3864:i
3859:e
3854:d
3849:a
3847:(
3833:c
3828:b
3823:a
3650:b
3645:a
3633:b
3628:a
3556:b
3551:a
3424:k
3419:j
3414:h
3409:e
3404:d
3399:a
3362:b
3357:a
3305:f
3300:e
3295:d
3290:c
3285:b
3280:a
3268:C
3263:B
3258:A
3241:P
3236:L
3231:E
3153:f
3148:e
3143:d
3138:c
3133:b
3128:a
3086:d
3081:c
3076:b
3071:a
3014:B
3009:A
2927:B
2922:A
2895:d
2890:c
2885:b
2880:a
2858:a
2826:ε
2821:δ
2816:γ
2761:)
2743:e
2736:t
2729:v
2667:e
2660:t
2653:v
2640:.
2610:.
2590:.
2578::
2561:.
2541::
2523:.
2503::
2486:.
2454:.
2430:.
2408::
2402:6
2381:.
2355:.
2325:.
2303::
2276:.
2252::
2246:7
2225:.
2203::
2176:.
2162::
2135:.
2121::
2094:.
2080::
2053:.
2039::
2012:.
1998::
1971:.
1957::
1916:.
1891:.
1869::
1842:.
1830::
1824:7
1807:.
1795::
1769:.
1752:.
1728::
1720::
1693:.
1675:.
1529:.
1517:,
1511:,
1336:(
343:)
240:)
223::
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59:(
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50:(
36:.
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