1164:
a full-length protein, however, suggesting that PCP-2 does not mediate homophilic adhesion in cells. The MAM and Ig domains of PCP-2 are capable of mediating weak cell-cell adhesion when swapped into the wild-type PTPrho protein, demonstrating that the MAM and Ig domain can mediate weak cell adhesion, but that they require other functional domains within PTPrho to mediate cell-cell adhesion. The Ig domain of the R2B RPTP, PTPmu, is sufficient to mediate bead aggregation in vitro, therefore, it is possible that the PCP-2 constructs used by Cheng and colleagues were able to mediate bead aggregation due to a functional Ig domain in PCP-2. A functional Ig domain itself would not be sufficient to mediate cell-cell adhesion, however. Similar to other subfamily members, PCP-2 does not mediate heterophilic binding between different R2B RPTPs.
244:
221:
1102:
extracellular region, a single transmembrane region, and two tandem intracellular catalytic tyrosine phosphatase domains, and thus represents a receptor-type PTP (RPTP). The extracellular region contains a meprin-A5 antigen-PTPmu (MAM) domain, one Ig-like domain and four fibronectin type III-like repeats, and thus is a member of the type R2B RPTP family. It was cloned by many groups and given different names, including PCP-2, PTP pi, PTP lambda, hPTP-J, PTPRO, and PTP psi. Other type R2B RPTPs include
1118:
domain of PCP-2 is catalytically active and able to dephosphorylate Ξ²-catenin. A recombinant protein with both PCP-2 phosphatase domains was also able to dephosphorylate EGFR. However, when each of the two intracellular catalytic tyrosine phosphatase domains are expressed individually as recombinant proteins and assayed in vitro using the artificial substrate Ο-nitrophenol phosphate (pNPP), both the first and second intracellular tyrosine phosphatase domain were able to dephosphorylate pNPP.
118:
143:
1194:
hindbrain. PCP-2 was also detected in the developing inner nuclear layer of the retina, in the olfactory epithelium of the nasal cavities, and in the meningeal coverings of the brain. In the developing chick nervous system, PCP-2 mRNA is expressed in the ventral midline of the neural tube and in the border between the midbrain and hindbrain, known as the mid-hindbrain boundary. PCP-2 mRNA is also observed in the ventricular zone of the developing chick neural retina.
495:
1180:(Ξ²-catenin) in cellular lysates. and to directly bind to Ξ²-catenin likely via a sequence in the juxtamembrane domain of PCP-2. Ξ²-catenin has since been shown to be a substrate of PCP-2. PCP-2 phosphatase activity antagonizes Ξ²-catenin mediated transcription. A consequence of PCP-2 dephosphorylation of Ξ²-catenin is to promote E-cadherin mediated cell-cell adhesion, reduce cellular migration, and to reduce cell growth and transformation.
250:
149:
1218:
shortening of the body axis, and disruption of anteroposterior polarity within developing somites. Ultimately, PCP-2 was shown to reduce the expression of the somitogenesis clock genes her1, her7 and delta C, suggesting to the authors that PCP-2 is involved either upstream or in parallel with the Notch-delta signaling pathway during zebrafish development.
1154:
Examination of mouse full-length cDNA sequences for alternatively spliced phosphatase genes identified two novel forms of PTPRU predicted to result in two PCP-2 splice variants: a tethered variant of PCP-2, expressing an intact extracellular and transmembrane domain, and a PCP-2 variant that lacked a
1163:
The MAM, Ig and first fibronectin III domain of PCP-2 was shown to mediate bead aggregation in vitro. PCP-2 accomplishes this by binding to another PCP-2 molecule on a fluorescent bead, known as homophilic binding. PCP-2 was unable to mediate aggregation between non-adherent cells when expressed as
1117:
RPTPs are able to remove phosphate moieties from tyrosine residues. Although the R2B family of RPTPs are characterized as having two tyrosine phosphatase domains in their intracellular domain, usually only one is catalytically active. A point mutation study suggests that only the first phosphatase
1126:
The X-ray crystallographic structure of the first PTPRU phopshatase (D1) domain shows that several divergent sequences in key catalytic motifs result in structural rearrangements that render this domain catalytically inactive. Phosphatase activity for the PTPRU D1 phosphatase domain is undetectable
1217:
Using morpholinos to reduce PCP-2 (PTP psi) protein expression in zebrafish embryos, Aerne and Ish-Horowicz demonstrated that PCP-2 was required for somite, or body segment, formation during zebrafish development. Reduction of PCP-2 expression resulted in the loss of boundaries between somites,
1221:
PCP-2 is expressed in megakaryocytic cell lines. PCP-2 protein expression in these cell lines is increased by PMA stimulation. PCP-2 and the c-Kit tyrosine kinase receptor interact constitutively in these cells, and PCP-2 was shown to be tyrosine phosphorylated upon stimulation with the c-Kit
1197:
PCP-2 is expressed in non-neural tissues during development, including the first forming somite in chick, known as S2, the lens fiber cells of the eye, in the esophagus, scleretome, kidneys, lungs, enamel organs (early incisor and molar teeth), and the cochlear ducts of the inner ear. PCP-2
1193:
PCP-2 is expressed in the developing mouse nervous system. In specific, it is expressed in the roof plate and floor plate of the developing spinal cord between embryonic days (E) 10.5 and 13.5. At the same developmental time, it is expressed in the ventricular zone in the telecephalon and
1101:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an
1131:, in this case a pseudophosphatase. Despite a lack of catalytic activity, PTPRU is able to bind the substrates of the related RPTP, PTPRK. Removal of PTPRU from MCF10A breast epithelial cells leads to a reduction in phosphorylation of the cell adhesion protein
1420:
Avraham S, London R, Tulloch GA, Ellis M, Fu Y, Jiang S, White RA, Painter C, Steinberger AA, Avraham H (Feb 1998). "Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells".
1582:
Wang B, Kishihara K, Zhang D, Hara H, Nomoto K (1997). "Molecular cloning and characterization of a novel human receptor protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells".
2325:
Badde A, Bumsted-O'Brien KM, Schulte D (2005). "Chick receptor protein tyrosine phosphatase lambda/psi (cRPTPlambda/cRPTPpsi) is dynamically expressed at the midbrain-hindbrain boundary and in the embryonic neural retina".
1946:
Wang B, Kishihara K, Zhang D, Sakamoto T, Nomoto K (1999). "Transcriptional regulation of a receptor protein tyrosine phosphatase gene hPTP-J by PKC-mediated signaling pathways in Jurkat and Molt-4 T lymphoma cells".
2470:
Taniguchi Y, London R, Schinkmann K, Jiang S, Avraham H (1999). "The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor".
1127:
against a range of phosphorylated substrates, and the full PTPRU intracellular domain cannot dephosphorylate pNPP, suggesting PTPRU completely lacks phosphatase activity. PTPRU can therefore be classified as a
2550:
Dong H, Yuan H, Jin W, Shen Y, Xu X, Wang H (2007). "Involvement of beta3A subunit of adaptor protein-3 in intracellular trafficking of receptor-like protein tyrosine phosphatase PCP-2".
1222:
ligand, SCF. Antisense oligonucleotide treatment of megakaryocyte cells to reduce PCP-2 protein expression resulted in a significant reduction in megakaryocyte progenitor proliferation.
1209:. Both Nurr1 and Pitx3 are required for the development of mdDA neurons in the brain. This suggests that PCP-2 is also an important downstream gene for the development of mdDA neurons.
2641:
50:, FMI, PCP-2, PTP, PTP-J, PTP-PI, PTP-RO, PTPPSI, PTPRO, PTPU2, R-PTP-PSI, R-PTP-U, hPTP-J, protein tyrosine phosphatase, receptor type U, protein tyrosine phosphatase receptor type U
1794:
Yan HX, He YQ, Dong H, Zhang P, Zeng JZ, Cao HF, et al. (2002). "Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin".
1893:
Reiterer V, PawΕowski K, Desrochers G, Pause A, Sharpe HJ, Farhan H (October 2020). "The dead phosphatases society: a review of the emerging roles of pseudophosphatases".
1143:
PCP-2 mRNA is regulated by phorbol myristate acetate (PMA) or calcium ionophore, okadaic acid, the Ras inhibitor manumycin, and orthovanadate in Jurkat T lymphoma cells.
257:
156:
1390:
Wang H, Lian Z, Lerch MM, Chen Z, Xie W, Ullrich A (Sep 1996). "Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family".
2418:
Aerne B, Ish-Horowicz D (2004). "Receptor tyrosine phosphatase psi is required for Delta/Notch signalling and cyclic gene expression in the presomitic mesoderm".
2133:
He Y, Yan H, Dong H, Zhang P, Tang L, Qiu X, et al. (2005). "Structural basis of interaction between protein tyrosine phosphatase PCP-2 and beta-catenin".
1201:
PCP-2 is expressed in meso-diencephalic dopamine (mdDA) neurons. Its expression here is regulated by the coordinated activity of the orphan nuclear receptor
2634:
788:
769:
79:
2627:
2227:"RPTP delta and the novel protein tyrosine phosphatase RPTP psi are expressed in restricted regions of the developing central nervous system"
1369:
1351:
3405:
243:
2595:
1027:
2243:
2226:
1020:
1623:
Aerne B, Stoker A, Ish-Horowicz D (2003). "Chick receptor tyrosine phosphatase Psi is dynamically expressed during somitogenesis".
220:
1459:
1660:"Genomic structure and alternative splicing of murine R2B receptor protein tyrosine phosphatases (PTPkappa, mu, rho and PCP-2)"
1338:
1317:
1334:
2607:
142:
117:
2683:
1313:
3361:
3326:
3308:
2903:
2667:
2654:
59:
2181:"Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion"
256:
155:
1135:, suggesting PTPRU binding may act to sequester and protect proteins from dephosphorylation by active phosphatases.
1114:. Analysis of the genomic structure of PCP-2 suggests that it is the most distantly related of the type R2B RPTPS.
249:
148:
2658:
833:
67:
2042:"Characterization of the adhesive properties of the type IIb subfamily receptor protein tyrosine phosphatases"
814:
2368:"Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons"
1709:
Johnson KG, Van Vactor D (2003). "Receptor protein tyrosine phosphatases in nervous system development".
1172:
PCP-2 was localized to cell-cell contact sites using immunohistochemistry, and shown to co-localize with
2619:
1231:
1480:"Molecular cloning and characterization of PTP pi, a novel receptor-like protein-tyrosine phosphatase"
1849:
131:
1151:
Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
46:
2613:
2601:
2091:"Identification of the homophilic binding site of the receptor protein tyrosine phosphatase PTP mu"
1534:"A novel protein-tyrosine phosphatase related to the homotypically adhering kappa and mu receptors"
999:
966:
936:
903:
3164:
2575:
2443:
2304:
2275:"Differential expression of MAM-subfamily protein tyrosine phosphatases during mouse development"
2158:
1928:
91:
3197:
1003:
978:
974:
970:
940:
915:
911:
907:
2567:
2529:
2488:
2435:
2397:
2343:
2296:
2248:
2202:
2150:
2112:
2071:
2015:
1964:
1920:
1875:
1811:
1767:
1726:
1691:
1640:
1600:
1555:
1509:
1438:
1399:
494:
39:
3094:
3089:
3058:
2975:
2366:
Jacobs FM, van der Linden AJ, Wang Y, von
Oerthel L, Sul HS, Burbach JP, et al. (2009).
3290:
3280:
3270:
3265:
3144:
3139:
3134:
3119:
3099:
3079:
2916:
2872:
2791:
2559:
2519:
2480:
2427:
2387:
2379:
2335:
2286:
2238:
2192:
2142:
2102:
2061:
2053:
2005:
1995:
1984:"Genome-wide review of transcriptional complexity in mouse protein kinases and phosphatases"
1956:
1910:
1902:
1865:
1857:
1803:
1757:
1718:
1681:
1671:
1632:
1592:
1545:
1499:
1491:
1430:
336:
267:
211:
166:
3255:
3250:
3240:
3235:
3154:
2960:
1206:
87:
3379:
3187:
311:
2506:
McArdle L, Rafferty M, Maelandsmo GM, Bergin O, Farr CJ, Dervan PA, et al. (2001).
1853:
3220:
2392:
2367:
2066:
2041:
2010:
1983:
1870:
1837:
1504:
1479:
1132:
2291:
2274:
2107:
2090:
1960:
1746:"Receptor protein tyrosine phosphatases regulate neural development and axon guidance"
1686:
1659:
1636:
1434:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
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633:
628:
612:
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587:
571:
566:
561:
556:
551:
546:
541:
536:
3399:
2563:
2524:
2507:
1932:
523:
2579:
2162:
1982:
Forrest AR, Taylor DF, Crowe ML, Chalk AM, Waddell NJ, Kolle G, et al. (2006).
71:
3212:
2447:
2308:
1128:
329:
108:
1250:
2339:
2057:
95:
3182:
1762:
1745:
1374:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1356:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1861:
1722:
412:
1173:
228:
125:
75:
2484:
1550:
1533:
1177:
733:
472:
350:
295:
282:
194:
181:
83:
2571:
2533:
2492:
2439:
2401:
2347:
2206:
2197:
2180:
2154:
2075:
2019:
2000:
1968:
1924:
1879:
1815:
1771:
1730:
1695:
1676:
1644:
1596:
1205:
binding to the PCP-2 promoter along with the homeobox transcription factor
1198:
expression in most of these tissue changes over the course of development.
2300:
2252:
2116:
1604:
1559:
1513:
1442:
1403:
1155:
signal peptide, but encoded intact transmembrane and cytoplasmic domains.
1067:
1062:
2650:
2040:
Becka S, Zhang P, Craig SE, Lodowski DT, Wang Z, Brady-Kalnay SM (2010).
1235:
1051:
878:
859:
2244:
10.1002/(SICI)1097-0177(199701)208:1<48::AID-AJA5>3.0.CO;2-1
2383:
2146:
1915:
1906:
845:
800:
2431:
1836:
Hay IM, Fearnley GW, Rios P, KΓΆhn M, Sharpe HJ, Deane JE (June 2020).
1807:
1495:
3349:
3344:
3339:
3285:
3275:
3149:
3129:
3124:
3114:
3109:
3104:
3084:
3048:
3043:
3027:
3022:
3017:
2970:
2965:
2887:
2882:
2877:
2867:
2862:
2857:
2852:
2847:
2786:
2751:
2179:
Yan HX, Yang W, Zhang R, Chen L, Tang L, Zhai B, et al. (2006).
1083:
1082:(also known as PTP-pi, PTP lambda, hPTP-J, PTPRO and PTP psi), is an
1035:
755:
644:
transmembrane receptor protein tyrosine phosphatase signaling pathway
1532:
Cheng J, Wu K, Armanini M, O'Rourke N, Dowbenko D, Lasky LA (1997).
1460:"Entrez Gene: PTPRU protein tyrosine phosphatase, receptor type, U"
3334:
3260:
3245:
3230:
3225:
3202:
3159:
3074:
3053:
2955:
2950:
2945:
2940:
2935:
2930:
2925:
2842:
2837:
2832:
2827:
2822:
2817:
2812:
2807:
2776:
2771:
2766:
2761:
2756:
2746:
2741:
2736:
2731:
2726:
2721:
2716:
2711:
2706:
2701:
2696:
2691:
1289:
1276:
1272:
1268:
1264:
1260:
1256:
1202:
1111:
1107:
1103:
718:
714:
3384:
3374:
3369:
3316:
3192:
3001:
2996:
2991:
1658:
Besco J, Popesco MC, Davuluri RV, Frostholm A, Rotter A (2004).
1283:
1090:
503:
63:
2623:
2508:"Protein tyrosine phosphatase genes downregulated in melanoma"
704:
positive regulation of cell-cell adhesion mediated by cadherin
557:
transmembrane receptor protein tyrosine phosphatase activity
1838:"The receptor PTPRU is a redox sensitive pseudophosphatase"
319:
2273:
Fuchs M, Wang H, Ciossek T, Chen Z, Ullrich A (1998).
699:
negative regulation of canonical Wnt signaling pathway
1176:
and catenins. PCP-2 was shown to be associated with
484:
669:
negative regulation of cell population proliferation
3360:
3325:
3307:
3211:
3173:
3067:
3036:
3010:
2984:
2915:
2900:
2800:
2682:
2675:
2666:
992:
959:
929:
896:
1330:
1328:
1326:
1309:
1307:
1305:
266:
165:
1080:Receptor-type tyrosine-protein phosphatase PCP-2
2545:
2543:
2465:
2463:
2461:
2459:
2457:
2413:
2411:
2361:
2359:
2357:
2320:
2318:
2174:
2172:
2128:
2126:
2035:
2033:
2031:
2029:
1789:
1787:
1785:
1783:
1781:
1618:
1616:
1614:
18:Protein-coding gene in the species Homo sapiens
2268:
2266:
2264:
2262:
2220:
2218:
2216:
1577:
1575:
1573:
1571:
1569:
1335:GRCm38: Ensembl release 89: ENSMUSG00000028909
2635:
1527:
1525:
1523:
1473:
1471:
1469:
1415:
1413:
1385:
1383:
1246:PCP-2 interacts with the following proteins:
8:
1478:Crossland S, Smith PD, Crompton MR (1996).
1314:GRCh38: Ensembl release 89: ENSG00000060656
2912:
2679:
2672:
2642:
2628:
2620:
1744:Ensslen-Craig SE, Brady-Kalnay SM (2004).
729:
519:
307:
206:
103:
2523:
2391:
2290:
2242:
2196:
2106:
2065:
2009:
1999:
1914:
1869:
1761:
1685:
1675:
1549:
1503:
1168:Regulation of cadherin-dependent adhesion
1454:
1452:
1301:
20:
2225:Sommer L, Rao M, Anderson DJ (1997).
1831:
1829:
1827:
1825:
1234:because of its reduced expression in
649:negative regulation of cell migration
603:integral component of plasma membrane
567:protein tyrosine phosphatase activity
271:
232:
227:
170:
129:
124:
7:
654:protein localization to cell surface
2552:Acta Biochim Biophys Sin (Shanghai)
684:peptidyl-tyrosine dephosphorylation
542:phosphoprotein phosphatase activity
2089:Brady-Kalnay SM, Tonks NK (1994).
989:
956:
926:
893:
869:
850:
824:
805:
779:
760:
489:
407:
345:
324:
14:
1086:that in humans is encoded by the
2564:10.1111/j.1745-7270.2007.00303.x
2525:10.1046/j.0022-202x.2001.01534.x
493:
255:
248:
242:
219:
154:
147:
141:
116:
664:canonical Wnt signaling pathway
447:Region II of hippocampus proper
588:integral component of membrane
504:More reference expression data
473:More reference expression data
365:olfactory zone of nasal mucosa
1:
2655:protein tyrosine phosphatases
2292:10.1016/S0925-4773(97)00179-2
2108:10.1016/S0021-9258(18)46951-7
1961:10.1016/S0167-4889(99)00064-6
1637:10.1016/S1567-133X(03)00038-3
1435:10.1016/S0378-1119(97)00420-4
240:
139:
2340:10.1016/j.modgep.2005.04.002
2058:10.3109/15419061.2010.487957
1122:PTPRU as a pseudophosphatase
639:homotypic cell-cell adhesion
3406:Genes on human chromosome 1
2600:human gene location in the
2135:Science China Life Sciences
1763:10.1016/j.ydbio.2004.08.009
1230:PCP-2 is predicted to be a
3422:
2612:human gene details in the
1862:10.1038/s41467-020-17076-w
1723:10.1152/physrev.00016.2002
1585:Biochem Biophys Res Commun
634:response to glucocorticoid
1370:"Mouse PubMed Reference:"
1352:"Human PubMed Reference:"
1066:
1061:
1057:
1050:
1034:
1028:Chr 4: 131.77 β 131.84 Mb
1015:
996:
963:
952:
933:
900:
889:
876:
872:
857:
853:
844:
831:
827:
812:
808:
799:
786:
782:
767:
763:
754:
739:
732:
728:
712:
689:protein dephosphorylation
659:animal organ regeneration
572:identical protein binding
522:
518:
501:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
1255:Adaptor protein-3 (AP3;
2485:10.1182/blood.V94.2.539
1551:10.1074/jbc.272.11.7264
1238:tissue and cell lines.
1021:Chr 1: 29.24 β 29.33 Mb
3174:Phosphatase and tensin
2801:Non receptor type PTPs
2198:10.1074/jbc.M602607200
2001:10.1186/gb-2006-7-1-r5
1677:10.1186/1471-2164-5-14
1597:10.1006/bbrc.1997.6004
443:superior frontal gyrus
431:neural layer of retina
1842:Nature Communications
1232:tumor suppressor gene
435:primary visual cortex
273:4 D2.3|4 64.5 cM
1949:Biochim Biophys Acta
1147:Alternative splicing
629:cell differentiation
547:phosphatase activity
537:beta-catenin binding
234:Chromosome 4 (mouse)
132:Chromosome 1 (human)
2614:UCSC Genome Browser
2602:UCSC Genome Browser
1854:2020NatCo..11.3219H
1189:Tissue distribution
1184:Role in development
389:trigeminal ganglion
361:canal of the cervix
2684:Receptor type PTPs
2384:10.1242/dev.037556
2328:Gene Expr Patterns
2147:10.1007/bf02879669
1907:10.1111/febs.15431
1625:Gene Expr Patterns
1159:Homophilic binding
834:ENSMUSG00000028909
694:cell-cell adhesion
622:Biological process
598:cell-cell junction
581:Cellular component
562:hydrolase activity
530:Molecular function
385:right uterine tube
3393:
3392:
3303:
3302:
3299:
3298:
2917:MAPK phosphatases
2896:
2895:
2512:J Invest Dermatol
2432:10.1242/dev.01222
2046:Cell Commun Adhes
1901:(19): 4198β4220.
1808:10.1021/bi026095u
1496:10.1042/bj3190249
1282:Sorting nexin 3 (
1077:
1076:
1073:
1072:
1046:
1045:
1011:
1010:
986:
985:
948:
947:
923:
922:
885:
884:
866:
865:
840:
839:
821:
820:
795:
794:
776:
775:
724:
723:
674:dephosphorylation
514:
513:
510:
509:
479:
478:
466:
465:
455:cerebellar cortex
404:
403:
302:
301:
201:
200:
96:PTPRU - orthologs
3413:
3176:homologs (PTENs)
2913:
2680:
2673:
2644:
2637:
2630:
2621:
2584:
2583:
2547:
2538:
2537:
2527:
2503:
2497:
2496:
2467:
2452:
2451:
2415:
2406:
2405:
2395:
2363:
2352:
2351:
2322:
2313:
2312:
2294:
2270:
2257:
2256:
2246:
2222:
2211:
2210:
2200:
2191:(22): 15423β33.
2176:
2167:
2166:
2130:
2121:
2120:
2110:
2086:
2080:
2079:
2069:
2037:
2024:
2023:
2013:
2003:
1979:
1973:
1972:
1943:
1937:
1936:
1918:
1895:The FEBS Journal
1890:
1884:
1883:
1873:
1833:
1820:
1819:
1802:(52): 15854β60.
1791:
1776:
1775:
1765:
1741:
1735:
1734:
1706:
1700:
1699:
1689:
1679:
1655:
1649:
1648:
1620:
1609:
1608:
1579:
1564:
1563:
1553:
1529:
1518:
1517:
1507:
1475:
1464:
1463:
1456:
1447:
1446:
1417:
1408:
1407:
1387:
1378:
1377:
1366:
1360:
1359:
1348:
1342:
1332:
1321:
1311:
1059:
1058:
1030:
1023:
1006:
990:
981:
957:
953:RefSeq (protein)
943:
927:
918:
894:
870:
851:
825:
806:
780:
761:
730:
520:
506:
497:
490:
475:
423:ventricular zone
415:
413:Top expressed in
408:
381:nasal epithelium
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
49:
42:
21:
3421:
3420:
3416:
3415:
3414:
3412:
3411:
3410:
3396:
3395:
3394:
3389:
3356:
3321:
3295:
3207:
3175:
3169:
3063:
3032:
3006:
2980:
2908:
2905:
2902:
2892:
2796:
2662:
2648:
2592:
2587:
2549:
2548:
2541:
2505:
2504:
2500:
2469:
2468:
2455:
2417:
2416:
2409:
2378:(14): 2363β73.
2365:
2364:
2355:
2324:
2323:
2316:
2285:(1β2): 91β109.
2272:
2271:
2260:
2224:
2223:
2214:
2178:
2177:
2170:
2132:
2131:
2124:
2101:(45): 28472β7.
2088:
2087:
2083:
2039:
2038:
2027:
1981:
1980:
1976:
1945:
1944:
1940:
1892:
1891:
1887:
1835:
1834:
1823:
1793:
1792:
1779:
1743:
1742:
1738:
1708:
1707:
1703:
1657:
1656:
1652:
1622:
1621:
1612:
1581:
1580:
1567:
1544:(11): 7264β77.
1531:
1530:
1521:
1477:
1476:
1467:
1458:
1457:
1450:
1419:
1418:
1411:
1398:(12): 2555β62.
1389:
1388:
1381:
1368:
1367:
1363:
1350:
1349:
1345:
1333:
1324:
1312:
1303:
1299:
1244:
1228:
1215:
1191:
1186:
1170:
1161:
1149:
1141:
1124:
1099:
1068:View/Edit Mouse
1063:View/Edit Human
1026:
1019:
1016:Location (UCSC)
1002:
998:
977:
973:
969:
965:
939:
935:
914:
910:
906:
902:
815:ENSG00000060656
708:
617:
613:plasma membrane
576:
552:protein binding
502:
471:
462:
457:
453:
449:
445:
441:
437:
433:
429:
425:
411:
400:
395:
393:pars reticulata
391:
387:
383:
379:
375:
371:
367:
363:
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
19:
12:
11:
5:
3419:
3417:
3409:
3408:
3398:
3397:
3391:
3390:
3388:
3387:
3382:
3377:
3372:
3366:
3364:
3358:
3357:
3355:
3354:
3353:
3352:
3347:
3342:
3331:
3329:
3323:
3322:
3320:
3319:
3313:
3311:
3305:
3304:
3301:
3300:
3297:
3296:
3294:
3293:
3288:
3283:
3278:
3273:
3268:
3263:
3258:
3253:
3248:
3243:
3238:
3233:
3228:
3223:
3217:
3215:
3209:
3208:
3206:
3205:
3200:
3195:
3190:
3185:
3179:
3177:
3171:
3170:
3168:
3167:
3162:
3157:
3152:
3147:
3142:
3137:
3132:
3127:
3122:
3117:
3112:
3107:
3102:
3097:
3092:
3087:
3082:
3077:
3071:
3069:
3065:
3064:
3062:
3061:
3056:
3051:
3046:
3040:
3038:
3034:
3033:
3031:
3030:
3025:
3020:
3014:
3012:
3008:
3007:
3005:
3004:
2999:
2994:
2988:
2986:
2982:
2981:
2979:
2978:
2973:
2968:
2963:
2958:
2953:
2948:
2943:
2938:
2933:
2928:
2922:
2920:
2910:
2898:
2897:
2894:
2893:
2891:
2890:
2885:
2880:
2875:
2870:
2865:
2860:
2855:
2850:
2845:
2840:
2835:
2830:
2825:
2820:
2815:
2810:
2804:
2802:
2798:
2797:
2795:
2794:
2789:
2784:
2779:
2774:
2769:
2764:
2759:
2754:
2749:
2744:
2739:
2734:
2729:
2724:
2719:
2714:
2709:
2704:
2699:
2694:
2688:
2686:
2677:
2676:Classical PTPs
2670:
2664:
2663:
2649:
2647:
2646:
2639:
2632:
2624:
2618:
2617:
2605:
2591:
2590:External links
2588:
2586:
2585:
2539:
2518:(5): 1255β60.
2498:
2453:
2426:(14): 3391β9.
2407:
2353:
2314:
2258:
2212:
2168:
2122:
2081:
2025:
1974:
1938:
1885:
1821:
1777:
1736:
1701:
1650:
1610:
1565:
1519:
1465:
1448:
1409:
1379:
1361:
1343:
1322:
1300:
1298:
1295:
1294:
1293:
1287:
1280:
1253:
1243:
1240:
1227:
1226:Role in cancer
1224:
1214:
1211:
1190:
1187:
1185:
1182:
1169:
1166:
1160:
1157:
1148:
1145:
1140:
1137:
1123:
1120:
1098:
1095:
1075:
1074:
1071:
1070:
1065:
1055:
1054:
1048:
1047:
1044:
1043:
1041:
1039:
1032:
1031:
1024:
1017:
1013:
1012:
1009:
1008:
994:
993:
987:
984:
983:
961:
960:
954:
950:
949:
946:
945:
931:
930:
924:
921:
920:
898:
897:
891:
887:
886:
883:
882:
874:
873:
867:
864:
863:
855:
854:
848:
842:
841:
838:
837:
829:
828:
822:
819:
818:
810:
809:
803:
797:
796:
793:
792:
784:
783:
777:
774:
773:
765:
764:
758:
752:
751:
746:
741:
737:
736:
726:
725:
722:
721:
710:
709:
707:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
625:
623:
619:
618:
616:
615:
610:
605:
600:
595:
590:
584:
582:
578:
577:
575:
574:
569:
564:
559:
554:
549:
544:
539:
533:
531:
527:
526:
516:
515:
512:
511:
508:
507:
499:
498:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
231:
225:
224:
216:
215:
203:
202:
199:
198:
190:
186:
185:
177:
174:
169:
163:
162:
153:
146:
140:
136:
135:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
3418:
3407:
3404:
3403:
3401:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3368:
3367:
3365:
3363:
3359:
3351:
3348:
3346:
3343:
3341:
3338:
3337:
3336:
3333:
3332:
3330:
3328:
3324:
3318:
3315:
3314:
3312:
3310:
3306:
3292:
3289:
3287:
3284:
3282:
3279:
3277:
3274:
3272:
3269:
3267:
3264:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3239:
3237:
3234:
3232:
3229:
3227:
3224:
3222:
3219:
3218:
3216:
3214:
3213:Myotubularins
3210:
3204:
3201:
3199:
3196:
3194:
3191:
3189:
3186:
3184:
3181:
3180:
3178:
3172:
3166:
3163:
3161:
3158:
3156:
3153:
3151:
3148:
3146:
3143:
3141:
3138:
3136:
3133:
3131:
3128:
3126:
3123:
3121:
3118:
3116:
3113:
3111:
3108:
3106:
3103:
3101:
3098:
3096:
3093:
3091:
3088:
3086:
3083:
3081:
3078:
3076:
3073:
3072:
3070:
3068:Atypical DSPs
3066:
3060:
3057:
3055:
3052:
3050:
3047:
3045:
3042:
3041:
3039:
3035:
3029:
3026:
3024:
3021:
3019:
3016:
3015:
3013:
3009:
3003:
3000:
2998:
2995:
2993:
2990:
2989:
2987:
2983:
2977:
2974:
2972:
2969:
2967:
2964:
2962:
2959:
2957:
2954:
2952:
2949:
2947:
2944:
2942:
2939:
2937:
2934:
2932:
2929:
2927:
2924:
2923:
2921:
2918:
2914:
2911:
2907:
2904:dual specific
2899:
2889:
2886:
2884:
2881:
2879:
2876:
2874:
2871:
2869:
2866:
2864:
2861:
2859:
2856:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2809:
2806:
2805:
2803:
2799:
2793:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2773:
2770:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2750:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2730:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2705:
2703:
2700:
2698:
2695:
2693:
2690:
2689:
2687:
2685:
2681:
2678:
2674:
2671:
2669:
2665:
2660:
2656:
2652:
2645:
2640:
2638:
2633:
2631:
2626:
2625:
2622:
2615:
2611:
2610:
2606:
2603:
2599:
2598:
2594:
2593:
2589:
2581:
2577:
2573:
2569:
2565:
2561:
2557:
2553:
2546:
2544:
2540:
2535:
2531:
2526:
2521:
2517:
2513:
2509:
2502:
2499:
2494:
2490:
2486:
2482:
2479:(2): 539β49.
2478:
2474:
2466:
2464:
2462:
2460:
2458:
2454:
2449:
2445:
2441:
2437:
2433:
2429:
2425:
2421:
2414:
2412:
2408:
2403:
2399:
2394:
2389:
2385:
2381:
2377:
2373:
2369:
2362:
2360:
2358:
2354:
2349:
2345:
2341:
2337:
2334:(6): 786β91.
2333:
2329:
2321:
2319:
2315:
2310:
2306:
2302:
2298:
2293:
2288:
2284:
2280:
2276:
2269:
2267:
2265:
2263:
2259:
2254:
2250:
2245:
2240:
2236:
2232:
2228:
2221:
2219:
2217:
2213:
2208:
2204:
2199:
2194:
2190:
2186:
2182:
2175:
2173:
2169:
2164:
2160:
2156:
2152:
2148:
2144:
2140:
2136:
2129:
2127:
2123:
2118:
2114:
2109:
2104:
2100:
2096:
2092:
2085:
2082:
2077:
2073:
2068:
2063:
2059:
2055:
2051:
2047:
2043:
2036:
2034:
2032:
2030:
2026:
2021:
2017:
2012:
2007:
2002:
1997:
1993:
1989:
1985:
1978:
1975:
1970:
1966:
1962:
1958:
1955:(3): 331β40.
1954:
1950:
1942:
1939:
1934:
1930:
1926:
1922:
1917:
1912:
1908:
1904:
1900:
1896:
1889:
1886:
1881:
1877:
1872:
1867:
1863:
1859:
1855:
1851:
1847:
1843:
1839:
1832:
1830:
1828:
1826:
1822:
1817:
1813:
1809:
1805:
1801:
1797:
1790:
1788:
1786:
1784:
1782:
1778:
1773:
1769:
1764:
1759:
1755:
1751:
1747:
1740:
1737:
1732:
1728:
1724:
1720:
1716:
1712:
1705:
1702:
1697:
1693:
1688:
1683:
1678:
1673:
1669:
1665:
1661:
1654:
1651:
1646:
1642:
1638:
1634:
1630:
1626:
1619:
1617:
1615:
1611:
1606:
1602:
1598:
1594:
1590:
1586:
1578:
1576:
1574:
1572:
1570:
1566:
1561:
1557:
1552:
1547:
1543:
1539:
1535:
1528:
1526:
1524:
1520:
1515:
1511:
1506:
1501:
1497:
1493:
1490:(1): 249β54.
1489:
1485:
1481:
1474:
1472:
1470:
1466:
1461:
1455:
1453:
1449:
1444:
1440:
1436:
1432:
1429:(1β2): 5β16.
1428:
1424:
1416:
1414:
1410:
1405:
1401:
1397:
1393:
1386:
1384:
1380:
1375:
1371:
1365:
1362:
1357:
1353:
1347:
1344:
1340:
1336:
1331:
1329:
1327:
1323:
1319:
1315:
1310:
1308:
1306:
1302:
1296:
1291:
1288:
1285:
1281:
1278:
1274:
1270:
1266:
1262:
1258:
1254:
1252:
1249:
1248:
1247:
1241:
1239:
1237:
1233:
1225:
1223:
1219:
1212:
1210:
1208:
1204:
1199:
1195:
1188:
1183:
1181:
1179:
1175:
1167:
1165:
1158:
1156:
1152:
1146:
1144:
1138:
1136:
1134:
1130:
1121:
1119:
1115:
1113:
1109:
1105:
1096:
1094:
1092:
1089:
1085:
1081:
1069:
1064:
1060:
1056:
1053:
1049:
1042:
1040:
1037:
1033:
1029:
1025:
1022:
1018:
1014:
1007:
1005:
1001:
995:
991:
988:
982:
980:
976:
972:
968:
962:
958:
955:
951:
944:
942:
938:
932:
928:
925:
919:
917:
913:
909:
905:
899:
895:
892:
890:RefSeq (mRNA)
888:
881:
880:
875:
871:
868:
862:
861:
856:
852:
849:
847:
843:
836:
835:
830:
826:
823:
817:
816:
811:
807:
804:
802:
798:
791:
790:
785:
781:
778:
772:
771:
766:
762:
759:
757:
753:
750:
747:
745:
742:
738:
735:
731:
727:
720:
716:
711:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
679:cell adhesion
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
626:
624:
621:
620:
614:
611:
609:
608:cell junction
606:
604:
601:
599:
596:
594:
591:
589:
586:
585:
583:
580:
579:
573:
570:
568:
565:
563:
560:
558:
555:
553:
550:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
397:Pars compacta
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
16:
2906:phosphatases
2781:
2608:
2596:
2558:(7): 540β6.
2555:
2551:
2515:
2511:
2501:
2476:
2472:
2423:
2419:
2375:
2371:
2331:
2327:
2282:
2278:
2237:(1): 48β61.
2234:
2230:
2188:
2184:
2141:(2): 163β7.
2138:
2134:
2098:
2094:
2084:
2052:(2): 34β47.
2049:
2045:
1991:
1987:
1977:
1952:
1948:
1941:
1898:
1894:
1888:
1845:
1841:
1799:
1796:Biochemistry
1795:
1756:(1): 12β22.
1753:
1749:
1739:
1714:
1710:
1704:
1667:
1664:BMC Genomics
1663:
1653:
1631:(3): 325β9.
1628:
1624:
1591:(1): 77β81.
1588:
1584:
1541:
1537:
1487:
1483:
1426:
1422:
1395:
1391:
1373:
1364:
1355:
1346:
1245:
1242:Interactions
1229:
1220:
1216:
1200:
1196:
1192:
1171:
1162:
1153:
1150:
1142:
1133:p120-Catenin
1129:pseudoenzyme
1125:
1116:
1100:
1087:
1079:
1078:
1000:NP_001076588
997:
967:NP_001181930
964:
937:NM_001083119
934:
904:NM_001195001
901:
877:
858:
832:
813:
787:
768:
748:
743:
373:tibial nerve
335:
328:
294:131,838,288
281:131,768,457
55:External IDs
15:
2901:VH1-like or
2420:Development
2372:Development
2185:J Biol Chem
2095:J Biol Chem
1988:Genome Biol
1916:10852/85557
1848:(1): 3219.
1717:(1): 1β24.
1711:Physiol Rev
1538:J Biol Chem
377:sural nerve
193:29,326,813
180:29,236,516
33:Identifiers
2985:Slingshots
1341:, May 2017
1320:, May 2017
1297:References
1174:E-cadherin
1139:Regulation
369:ectocervix
339:(ortholog)
76:HomoloGene
3327:Class III
2661:3.1.3.48)
1994:(1): R5.
1933:219168614
1670:(1): 14.
1484:Biochem J
1251:Ξ²-catenin
1178:B-catenin
1004:NP_035344
979:NP_573439
975:NP_573438
971:NP_005695
941:NM_011214
916:NM_133178
912:NM_133177
908:NM_005704
734:Orthologs
84:GeneCards
3400:Category
3362:Class IV
3309:Class II
2651:Esterase
2580:27621318
2572:17622474
2534:11710941
2493:10397721
2440:15226256
2402:19515692
2348:15922674
2279:Mech Dev
2207:16574648
2163:20799629
2155:15986889
2076:20521994
2020:16507138
1969:10395944
1925:32484316
1880:32591542
1816:12501215
1772:15464569
1750:Dev Biol
1731:12506125
1696:15040814
1645:12799079
1392:Oncogene
1337:–
1316:–
1292:receptor
1236:melanoma
1213:Function
1097:Function
1052:Wikidata
713:Sources:
593:membrane
451:gastrula
3095:DUSP13B
3090:DUSP13A
3059:PTP9Q22
2976:MK-STYX
2668:Class I
2448:9827113
2393:3266485
2309:9560178
2301:9510027
2253:8989520
2231:Dev Dyn
2117:7961788
2067:3337334
2011:1431701
1871:7320164
1850:Bibcode
1605:9070223
1560:9054423
1514:8870675
1505:1217761
1443:9434160
1404:8700514
1339:Ensembl
1318:Ensembl
846:UniProt
801:Ensembl
740:Species
719:QuickGO
459:saccule
314:pattern
72:1321151
40:Aliases
3350:CDC25C
3345:CDC25B
3340:CDC25A
3291:MTMR15
3286:MTMR14
3281:MTMR13
3276:MTMR12
3271:MTMR11
3266:MTMR10
3150:DUSP27
3145:DUSP26
3140:DUSP25
3135:DUSP24
3130:DUSP23
3125:DUSP22
3120:DUSP21
3115:DUSP19
3110:DUSP18
3105:DUSP15
3100:DUSP14
3085:DUSP12
3080:DUSP11
3049:CDC14B
3044:CDC14A
3037:CDC14s
3028:PTP4A3
3023:PTP4A2
3018:PTP4A1
2971:DUSP16
2966:DUSP10
2919:(MKPs)
2909:(DSPs)
2888:PTPN23
2883:PTPN22
2878:PTPN21
2873:PTPN20
2868:PTPN18
2863:PTPN14
2858:PTPN13
2853:PTPN12
2848:PTPN11
2792:PTPRZ2
2787:PTPRZ1
2752:PTPRN2
2578:
2570:
2532:
2491:
2446:
2438:
2400:
2390:
2346:
2307:
2299:
2251:
2205:
2161:
2153:
2115:
2074:
2064:
2018:
2008:
1967:
1931:
1923:
1878:
1868:
1814:
1770:
1729:
1694:
1687:373446
1684:
1643:
1603:
1558:
1512:
1502:
1441:
1402:
1110:, and
1084:enzyme
1038:search
1036:PubMed
879:B1AUH1
860:Q92729
756:Entrez
485:BioGPS
172:1p35.3
64:602454
3335:Cdc25
3261:MTMR9
3256:MTMR8
3251:MTMR7
3246:MTMR6
3241:MTMR5
3236:MTMR4
3231:MTMR3
3226:MTMR2
3203:TENC1
3160:RNGTT
3155:EMP2A
3075:DUSP3
3054:CDKN3
2961:DUSP9
2956:DUSP8
2951:DUSP7
2946:DUSP6
2941:DUSP5
2936:DUSP4
2931:DUSP2
2926:DUSP1
2843:PTPN9
2838:PTPN7
2833:PTPN6
2828:PTPN5
2823:PTPN4
2818:PTPN3
2813:PTPN2
2808:PTPN1
2782:PTPRU
2777:PTPRT
2772:PTPRS
2767:PTPRR
2762:PTPRQ
2757:PTPRO
2747:PTPRN
2742:PTPRM
2737:PTPRK
2732:PTPRJ
2727:PTPRH
2722:PTPRG
2717:PTPRF
2712:PTPRE
2707:PTPRD
2702:PTPRC
2697:PTPRB
2692:PTPRA
2609:PTPRU
2597:PTPRU
2576:S2CID
2473:Blood
2444:S2CID
2305:S2CID
2159:S2CID
1929:S2CID
1290:C-Kit
1277:AP3S2
1273:AP3S1
1269:AP3M1
1265:AP3D1
1261:AP3B2
1257:AP3B1
1207:Pitx3
1203:Nurr1
1112:PTPRT
1108:PTPRK
1104:PTPRM
1088:PTPRU
789:19273
770:10076
749:Mouse
744:Human
715:Amigo
439:molar
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
88:PTPRU
47:PTPRU
24:PTPRU
3385:EYA4
3380:EYA3
3375:EYA2
3370:EYA1
3317:ACP1
3221:MTM1
3193:TPTE
3188:TPIP
3183:PTEN
3165:STYX
3011:PRLs
3002:SSH3
2997:SSH2
2992:SSH1
2568:PMID
2530:PMID
2489:PMID
2436:PMID
2398:PMID
2344:PMID
2297:PMID
2249:PMID
2203:PMID
2151:PMID
2113:PMID
2072:PMID
2016:PMID
1965:PMID
1953:1450
1921:PMID
1876:PMID
1812:PMID
1768:PMID
1727:PMID
1692:PMID
1641:PMID
1601:PMID
1556:PMID
1510:PMID
1439:PMID
1423:Gene
1400:PMID
1284:SNX3
1091:gene
427:lens
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
80:4168
60:OMIM
3198:TNS
2560:doi
2520:doi
2516:117
2481:doi
2428:doi
2424:131
2388:PMC
2380:doi
2376:136
2336:doi
2287:doi
2239:doi
2235:208
2193:doi
2189:281
2143:doi
2103:doi
2099:269
2062:PMC
2054:doi
2006:PMC
1996:doi
1957:doi
1911:hdl
1903:doi
1899:287
1866:PMC
1858:doi
1804:doi
1758:doi
1754:275
1719:doi
1682:PMC
1672:doi
1633:doi
1593:doi
1589:231
1546:doi
1542:272
1500:PMC
1492:doi
1488:319
1431:doi
1427:204
290:End
189:End
92:OMA
68:MGI
3402::
2659:EC
2653::
2574:.
2566:.
2556:39
2554:.
2542:^
2528:.
2514:.
2510:.
2487:.
2477:94
2475:.
2456:^
2442:.
2434:.
2422:.
2410:^
2396:.
2386:.
2374:.
2370:.
2356:^
2342:.
2330:.
2317:^
2303:.
2295:.
2283:70
2281:.
2277:.
2261:^
2247:.
2233:.
2229:.
2215:^
2201:.
2187:.
2183:.
2171:^
2157:.
2149:.
2139:48
2137:.
2125:^
2111:.
2097:.
2093:.
2070:.
2060:.
2050:17
2048:.
2044:.
2028:^
2014:.
2004:.
1990:.
1986:.
1963:.
1951:.
1927:.
1919:.
1909:.
1897:.
1874:.
1864:.
1856:.
1846:11
1844:.
1840:.
1824:^
1810:.
1800:41
1798:.
1780:^
1766:.
1752:.
1748:.
1725:.
1715:83
1713:.
1690:.
1680:.
1666:.
1662:.
1639:.
1627:.
1613:^
1599:.
1587:.
1568:^
1554:.
1540:.
1536:.
1522:^
1508:.
1498:.
1486:.
1482:.
1468:^
1451:^
1437:.
1425:.
1412:^
1396:12
1394:.
1382:^
1372:.
1354:.
1325:^
1304:^
1275:,
1271:,
1267:,
1263:,
1259:,
1106:,
1093:.
717:/
296:bp
283:bp
195:bp
182:bp
90:;
86::
82:;
78::
74:;
70::
66:;
62::
2657:(
2643:e
2636:t
2629:v
2616:.
2604:.
2582:.
2562::
2536:.
2522::
2495:.
2483::
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2404:.
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2350:.
2338::
2332:5
2311:.
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2255:.
2241::
2209:.
2195::
2165:.
2145::
2119:.
2105::
2078:.
2056::
2022:.
1998::
1992:7
1971:.
1959::
1935:.
1913::
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1882:.
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1818:.
1806::
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1721::
1698:.
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1635::
1629:3
1607:.
1595::
1562:.
1548::
1516:.
1494::
1462:.
1445:.
1433::
1406:.
1376:.
1358:.
1286:)
1279:)
214:)
111:)
94::
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