244:
1093:
tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
221:
118:
143:
495:
250:
149:
1092:
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and
1561:
Caporali S, Alvino E, Levati L, Esposito AI, Ciomei M, Brasca MG, Del Bufalo D, Desideri M, Bonmassar E, Pfeffer U, D'Atri S (Sep 2012). "Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125".
1238:
Domínguez A, Ramos-Morales F, Romero F, Rios RM, Dreyfus F, Tortolero M, Pintor-Toro JA (Oct 1998). "hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG".
1427:
Bernal JA, Luna R, Espina A, Lázaro I, Ramos-Morales F, Romero F, Arias C, Silva A, Tortolero M, Pintor-Toro JA (Oct 2002). "Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis".
1282:
Zhang X, Horwitz GA, Prezant TR, Valentini A, Nakashima M, Bronstein MD, Melmed S (Jan 1999). "Structure, expression, and function of human pituitary tumor-transforming gene (PTTG)".
1866:
Zou H, McGarry TJ, Bernal T, Kirschner MW (Jul 1999). "Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis".
257:
156:
1144:
During
Mitosis CDK1 phosphorylate PTTG1 at Ser-165. PTTG1 is down-regulated in melanoma cells in response to the cyclin-dependent kinase inhibitor PHA-848125.
1895:
Kakar SS (Nov 1999). "Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG)".
763:
744:
79:
1969:"A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product"
1473:"A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product"
1829:
Kakar SS, Jennes L (1999). "Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis".
1220:
1202:
2313:
1714:
Kakar SS (1999). "Assignment of the human tumor transforming gene TUTR1 to chromosome band 5q35.1 by fluorescence in situ hybridization".
1681:"Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells"
1339:"Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells"
243:
1011:
2268:
McCabe CJ, Boelaert K, Tannahill LA, Heaney AP, Stratford AL, Khaira JS, Hussain S, Sheppard MC, Franklyn JA, Gittoes NJ (Sep 2002).
1018:
220:
1618:
1320:
1189:
1168:
1185:
2039:"Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis"
142:
117:
2123:
Jallepalli PV, Waizenegger IC, Bunz F, Langer S, Speicher MR, Peters JM, Kinzler KW, Vogelstein B, Lengauer C (May 2001).
50:, EAP1, HPTTG, PTTG, TUTR1, pituitary tumor-transforming 1, PTTG1 regulator of sister chromatid separation, securin, ECRAR
1164:
59:
2270:"Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors"
1102:
2082:"Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase"
1380:"Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase"
256:
155:
249:
148:
2168:"The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner"
808:
67:
789:
2080:
Romero F, Multon MC, Ramos-Morales F, Domínguez A, Bernal JA, Pintor-Toro JA, Tortolero M (Mar 2001).
1378:
Romero F, Multon MC, Ramos-Morales F, Domínguez A, Bernal JA, Pintor-Toro JA, Tortolero M (Mar 2001).
2230:
2179:
955:
951:
131:
1788:"Cloning and expression of human cDNA encoding human homologue of pituitary tumor transforming gene"
46:
1924:
Ramos-Morales F, Domínguez A, Romero F, Luna R, Multon MC, Pintor-Toro JA, Tortolero M (Jan 2000).
1512:
Ramos-Morales F, Domínguez A, Romero F, Luna R, Multon MC, Pintor-Toro JA, Tortolero M (Jan 2000).
994:
986:
943:
939:
919:
911:
890:
886:
965:
2256:
2205:
2154:
1955:
1854:
1817:
1739:
1543:
1453:
1264:
91:
990:
947:
915:
882:
2291:
2248:
2197:
2146:
2111:
2068:
2025:
1990:
1947:
1912:
1883:
1846:
1809:
1774:
1731:
1702:
1667:
1624:
1614:
1579:
1535:
1494:
1445:
1409:
1360:
1299:
1256:
494:
39:
2281:
2238:
2187:
2136:
2101:
2093:
2058:
2050:
2015:
1980:
1937:
1904:
1875:
1838:
1799:
1764:
1751:
Zhang X, Horwitz GA, Heaney AP, Nakashima M, Prezant TR, Bronstein MD, Melmed S (Feb 1999).
1723:
1692:
1657:
1649:
1606:
1571:
1525:
1484:
1437:
1399:
1391:
1350:
1291:
1248:
336:
267:
211:
166:
87:
311:
2234:
2183:
1662:
1637:
2243:
2218:
2192:
2167:
2141:
2124:
2063:
2038:
1908:
678:
673:
668:
663:
658:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
603:
587:
582:
577:
561:
556:
551:
546:
541:
536:
2307:
2106:
2081:
1926:"Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product"
1514:"Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product"
1404:
1379:
523:
2260:
2209:
2158:
1959:
1858:
1821:
1743:
1547:
1268:
71:
1457:
329:
108:
1879:
95:
1225:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1207:
National Center for
Biotechnology Information, U.S. National Library of Medicine
412:
1804:
1787:
1575:
228:
125:
75:
2054:
2097:
1395:
708:
472:
350:
295:
282:
194:
181:
83:
2295:
2286:
2269:
2252:
2201:
2150:
2115:
2072:
2029:
2020:
2003:
1994:
1985:
1968:
1951:
1942:
1925:
1916:
1887:
1850:
1813:
1778:
1753:"Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas"
1697:
1680:
1671:
1628:
1583:
1539:
1530:
1513:
1498:
1489:
1472:
1449:
1413:
1355:
1338:
1252:
1735:
1706:
1364:
1303:
1260:
1058:
1053:
1638:"The emerging role of pituitary tumor transforming gene in tumorigenesis"
1042:
857:
838:
834:
1769:
1752:
1653:
1295:
1601:
Yu R, Melmed S (2004). "Pituitary tumor transforming gene: an update".
1126:
1074:
820:
775:
1842:
1727:
1610:
1109:
1026:
730:
562:
DNA-binding transcription factor activity, RNA polymerase II-specific
2166:
Hilioti Z, Chung YS, Mochizuki Y, Hardy CF, Cohen-Fix O (Sep 2001).
2219:"Regulation of human separase by securin binding and autocleavage"
1441:
1132:
2217:
Waizenegger I, Giménez-Abián JF, Wernic D, Peters JM (Aug 2002).
693:
689:
1605:. Frontiers of Hormone Research. Vol. 32. pp. 175–85.
1115:
1081:
63:
503:
2125:"Securin is required for chromosomal stability in human cells"
2004:"Human pituitary tumor-transforming gene induces angiogenesis"
2002:
Ishikawa H, Heaney AP, Yu R, Horwitz GA, Melmed S (Feb 2001).
1120:
1636:
Tfelt-Hansen J, Kanuparthi D, Chattopadhyay N (Jun 2006).
674:
negative regulation of mitotic sister chromatid separation
319:
639:
anaphase-promoting complex-dependent catabolic process
484:
2274:
The
Journal of Clinical Endocrinology and Metabolism
2008:
The
Journal of Clinical Endocrinology and Metabolism
1757:
The
Journal of Clinical Endocrinology and Metabolism
1321:"Entrez Gene: PTTG1 pituitary tumor-transforming 1"
979:
938:
904:
875:
1181:
1179:
1177:
1160:
1158:
1156:
266:
165:
1792:Biochemistry and Molecular Biology International
664:regulation of transcription by RNA polymerase II
16:Protein-coding gene in the species Homo sapiens
1186:GRCm38: Ensembl release 89: ENSMUSG00000020415
542:cysteine-type endopeptidase inhibitor activity
1332:
1330:
679:ubiquitin-dependent protein catabolic process
659:negative regulation of endopeptidase activity
8:
1165:GRCh38: Ensembl release 89: ENSG00000164611
935:
704:
649:regulation of transcription, DNA-templated
519:
307:
206:
103:
2285:
2242:
2191:
2140:
2105:
2062:
2019:
1984:
1941:
1803:
1768:
1696:
1661:
1529:
1488:
1403:
1354:
654:negative regulation of peptidase activity
547:DNA-binding transcription factor activity
1315:
1313:
619:cellular response to DNA damage stimulus
1152:
20:
1786:Lee IA, Seong C, Choe IS (May 1999).
271:
232:
227:
170:
129:
124:
7:
1603:Molecular Pathology of the Pituitary
1973:The Journal of Biological Chemistry
1685:The Journal of Biological Chemistry
1477:The Journal of Biological Chemistry
1343:The Journal of Biological Chemistry
976:
901:
872:
848:
825:
799:
780:
754:
735:
669:transcription by RNA polymerase II
489:
407:
345:
324:
14:
1077:that in humans is encoded by the
614:homologous chromosome segregation
1642:Clinical Medicine & Research
493:
255:
248:
242:
219:
154:
147:
141:
116:
2037:Zur A, Brandeis M (Feb 2001).
1831:Cytogenetics and Cell Genetics
1716:Cytogenetics and Cell Genetics
504:More reference expression data
473:More reference expression data
1:
2244:10.1016/S0960-9822(02)01073-4
2193:10.1016/S0960-9822(01)00399-2
2142:10.1016/S0092-8674(01)00340-3
1909:10.1016/S0378-1119(99)00446-1
240:
139:
1880:10.1126/science.285.5426.418
537:peptidase inhibitor activity
2314:Genes on human chromosome 5
1967:Chien W, Pei L (Jun 2000).
1471:Chien W, Pei L (Jun 2000).
2330:
435:retinal pigment epithelium
1805:10.1080/15216549900201993
1576:10.1016/j.bcp.2012.06.004
1221:"Mouse PubMed Reference:"
1203:"Human PubMed Reference:"
1057:
1052:
1048:
1041:
1025:
1012:Chr 5: 160.42 – 160.43 Mb
1006:
983:
962:
931:
908:
879:
868:
855:
851:
832:
828:
819:
806:
802:
787:
783:
774:
761:
757:
742:
738:
729:
714:
707:
703:
687:
522:
518:
501:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
1564:Biochemical Pharmacology
1101:PTTG1 has been shown to
1019:Chr 11: 43.31 – 43.32 Mb
1284:Molecular Endocrinology
609:chromosome organization
2287:10.1210/jc.2002-020309
2086:Nucleic Acids Research
2055:10.1093/emboj/20.4.792
2021:10.1210/jcem.86.2.7184
1986:10.1074/jbc.M910105199
1943:10.1038/sj.onc.1203320
1698:10.1074/jbc.274.5.3151
1531:10.1038/sj.onc.1203320
1490:10.1074/jbc.M910105199
1384:Nucleic Acids Research
1356:10.1074/jbc.274.5.3151
1253:10.1038/sj.onc.1202140
604:chromosome segregation
2098:10.1093/nar/29.6.1300
1396:10.1093/nar/29.6.1300
234:Chromosome 11 (mouse)
132:Chromosome 5 (human)
2235:2002CBio...12.1368W
2184:2001CBio...11.1347H
1770:10.1210/jc.84.2.761
1654:10.3121/cmr.4.2.130
1296:10.1210/me.13.1.156
397:mucosa of esophagus
385:gingival epithelium
373:ganglionic eminence
1679:Pei L (Jan 1999).
1337:Pei L (Jan 1999).
809:ENSMUSG00000020415
597:Biological process
571:Cellular component
552:SH3 domain binding
530:Molecular function
1843:10.1159/000015261
1728:10.1159/000015139
1611:10.1159/000079044
1068:
1067:
1064:
1063:
1037:
1036:
1002:
1001:
973:
972:
927:
926:
898:
897:
864:
863:
845:
844:
815:
814:
796:
795:
770:
769:
751:
750:
699:
698:
514:
513:
510:
509:
479:
478:
466:
465:
404:
403:
302:
301:
201:
200:
96:PTTG1 - orthologs
2321:
2299:
2289:
2264:
2246:
2213:
2195:
2162:
2144:
2119:
2109:
2076:
2066:
2043:The EMBO Journal
2033:
2023:
1998:
1988:
1963:
1945:
1920:
1891:
1874:(5426): 418–22.
1862:
1825:
1807:
1782:
1772:
1747:
1710:
1700:
1675:
1665:
1632:
1588:
1587:
1558:
1552:
1551:
1533:
1509:
1503:
1502:
1492:
1468:
1462:
1461:
1424:
1418:
1417:
1407:
1375:
1369:
1368:
1358:
1334:
1325:
1324:
1317:
1308:
1307:
1279:
1273:
1272:
1235:
1229:
1228:
1217:
1211:
1210:
1199:
1193:
1183:
1172:
1162:
1050:
1049:
1021:
1014:
997:
977:
968:
936:
932:RefSeq (protein)
922:
902:
893:
873:
849:
826:
800:
781:
755:
736:
705:
520:
506:
497:
490:
475:
451:primitive streak
427:secondary oocyte
415:
413:Top expressed in
408:
365:ventricular zone
361:secondary oocyte
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
49:
42:
21:
2329:
2328:
2324:
2323:
2322:
2320:
2319:
2318:
2304:
2303:
2302:
2267:
2229:(16): 1368–78.
2223:Current Biology
2216:
2178:(17): 1347–52.
2172:Current Biology
2165:
2122:
2079:
2036:
2001:
1979:(25): 19422–7.
1966:
1923:
1894:
1865:
1828:
1785:
1750:
1713:
1678:
1635:
1621:
1600:
1596:
1594:Further reading
1591:
1560:
1559:
1555:
1511:
1510:
1506:
1483:(25): 19422–7.
1470:
1469:
1465:
1430:Nature Genetics
1426:
1425:
1421:
1377:
1376:
1372:
1336:
1335:
1328:
1319:
1318:
1311:
1281:
1280:
1276:
1247:(17): 2187–93.
1237:
1236:
1232:
1219:
1218:
1214:
1201:
1200:
1196:
1184:
1175:
1163:
1154:
1150:
1142:
1099:
1090:
1059:View/Edit Mouse
1054:View/Edit Human
1017:
1010:
1007:Location (UCSC)
993:
989:
985:
964:
958:
954:
950:
946:
942:
918:
914:
910:
889:
885:
881:
837:
790:ENSG00000164611
683:
629:spermatogenesis
592:
566:
557:protein binding
502:
471:
462:
457:
453:
449:
445:
441:
437:
433:
429:
425:
411:
400:
395:
391:
389:trabecular bone
387:
383:
379:
375:
371:
367:
363:
349:
293:
280:
273:11|11 B1.1
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
17:
12:
11:
5:
2327:
2325:
2317:
2316:
2306:
2305:
2301:
2300:
2280:(9): 4238–44.
2265:
2214:
2163:
2120:
2077:
2049:(4): 792–801.
2034:
1999:
1964:
1921:
1892:
1863:
1837:(3–4): 211–6.
1826:
1783:
1748:
1711:
1676:
1633:
1619:
1597:
1595:
1592:
1590:
1589:
1570:(5): 598–611.
1553:
1504:
1463:
1419:
1370:
1326:
1309:
1274:
1230:
1212:
1194:
1173:
1151:
1149:
1146:
1141:
1138:
1137:
1136:
1130:
1124:
1118:
1113:
1098:
1095:
1089:
1086:
1066:
1065:
1062:
1061:
1056:
1046:
1045:
1039:
1038:
1035:
1034:
1032:
1030:
1023:
1022:
1015:
1008:
1004:
1003:
1000:
999:
981:
980:
974:
971:
970:
960:
959:
956:NP_001269312.1
952:NP_001269311.1
933:
929:
928:
925:
924:
906:
905:
899:
896:
895:
877:
876:
870:
866:
865:
862:
861:
853:
852:
846:
843:
842:
830:
829:
823:
817:
816:
813:
812:
804:
803:
797:
794:
793:
785:
784:
778:
772:
771:
768:
767:
759:
758:
752:
749:
748:
740:
739:
733:
727:
726:
721:
716:
712:
711:
701:
700:
697:
696:
685:
684:
682:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
621:
616:
611:
606:
600:
598:
594:
593:
591:
590:
585:
580:
574:
572:
568:
567:
565:
564:
559:
554:
549:
544:
539:
533:
531:
527:
526:
516:
515:
512:
511:
508:
507:
499:
498:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
439:primary oocyte
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
231:
225:
224:
216:
215:
203:
202:
199:
198:
190:
186:
185:
177:
174:
169:
163:
162:
153:
146:
140:
136:
135:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
2326:
2315:
2312:
2311:
2309:
2297:
2293:
2288:
2283:
2279:
2275:
2271:
2266:
2262:
2258:
2254:
2250:
2245:
2240:
2236:
2232:
2228:
2224:
2220:
2215:
2211:
2207:
2203:
2199:
2194:
2189:
2185:
2181:
2177:
2173:
2169:
2164:
2160:
2156:
2152:
2148:
2143:
2138:
2135:(4): 445–57.
2134:
2130:
2126:
2121:
2117:
2113:
2108:
2103:
2099:
2095:
2092:(6): 1300–7.
2091:
2087:
2083:
2078:
2074:
2070:
2065:
2060:
2056:
2052:
2048:
2044:
2040:
2035:
2031:
2027:
2022:
2017:
2014:(2): 867–74.
2013:
2009:
2005:
2000:
1996:
1992:
1987:
1982:
1978:
1974:
1970:
1965:
1961:
1957:
1953:
1949:
1944:
1939:
1935:
1931:
1927:
1922:
1918:
1914:
1910:
1906:
1903:(2): 317–24.
1902:
1898:
1893:
1889:
1885:
1881:
1877:
1873:
1869:
1864:
1860:
1856:
1852:
1848:
1844:
1840:
1836:
1832:
1827:
1823:
1819:
1815:
1811:
1806:
1801:
1797:
1793:
1789:
1784:
1780:
1776:
1771:
1766:
1762:
1758:
1754:
1749:
1745:
1741:
1737:
1733:
1729:
1725:
1722:(1–2): 93–5.
1721:
1717:
1712:
1708:
1704:
1699:
1694:
1691:(5): 3151–8.
1690:
1686:
1682:
1677:
1673:
1669:
1664:
1659:
1655:
1651:
1647:
1643:
1639:
1634:
1630:
1626:
1622:
1620:3-8055-7740-0
1616:
1612:
1608:
1604:
1599:
1598:
1593:
1585:
1581:
1577:
1573:
1569:
1565:
1557:
1554:
1549:
1545:
1541:
1537:
1532:
1527:
1523:
1519:
1515:
1508:
1505:
1500:
1496:
1491:
1486:
1482:
1478:
1474:
1467:
1464:
1459:
1455:
1451:
1447:
1443:
1442:10.1038/ng997
1439:
1436:(2): 306–11.
1435:
1431:
1423:
1420:
1415:
1411:
1406:
1401:
1397:
1393:
1390:(6): 1300–7.
1389:
1385:
1381:
1374:
1371:
1366:
1362:
1357:
1352:
1349:(5): 3151–8.
1348:
1344:
1340:
1333:
1331:
1327:
1322:
1316:
1314:
1310:
1305:
1301:
1297:
1293:
1290:(1): 156–66.
1289:
1285:
1278:
1275:
1270:
1266:
1262:
1258:
1254:
1250:
1246:
1242:
1234:
1231:
1226:
1222:
1216:
1213:
1208:
1204:
1198:
1195:
1191:
1187:
1182:
1180:
1178:
1174:
1170:
1166:
1161:
1159:
1157:
1153:
1147:
1145:
1139:
1134:
1131:
1128:
1125:
1122:
1119:
1117:
1114:
1111:
1108:
1107:
1106:
1104:
1096:
1094:
1087:
1085:
1083:
1080:
1076:
1072:
1060:
1055:
1051:
1047:
1044:
1040:
1033:
1031:
1028:
1024:
1020:
1016:
1013:
1009:
1005:
998:
996:
992:
988:
982:
978:
975:
969:
967:
961:
957:
953:
949:
945:
941:
937:
934:
930:
923:
921:
917:
913:
907:
903:
900:
894:
892:
888:
884:
878:
874:
871:
869:RefSeq (mRNA)
867:
860:
859:
854:
850:
847:
841:
840:
836:
831:
827:
824:
822:
818:
811:
810:
805:
801:
798:
792:
791:
786:
782:
779:
777:
773:
766:
765:
760:
756:
753:
747:
746:
741:
737:
734:
732:
728:
725:
722:
720:
717:
713:
710:
706:
702:
695:
691:
686:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
624:cell division
622:
620:
617:
615:
612:
610:
607:
605:
602:
601:
599:
596:
595:
589:
586:
584:
581:
579:
576:
575:
573:
570:
569:
563:
560:
558:
555:
553:
550:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
2277:
2273:
2226:
2222:
2175:
2171:
2132:
2128:
2089:
2085:
2046:
2042:
2011:
2007:
1976:
1972:
1936:(3): 403–9.
1933:
1929:
1900:
1896:
1871:
1867:
1834:
1830:
1798:(5): 891–7.
1795:
1791:
1763:(2): 761–7.
1760:
1756:
1719:
1715:
1688:
1684:
1648:(2): 130–7.
1645:
1641:
1602:
1567:
1563:
1556:
1524:(3): 403–9.
1521:
1517:
1507:
1480:
1476:
1466:
1433:
1429:
1422:
1387:
1383:
1373:
1346:
1342:
1287:
1283:
1277:
1244:
1240:
1233:
1224:
1215:
1206:
1197:
1143:
1100:
1097:Interactions
1091:
1078:
1070:
1069:
995:NP_001349728
987:NP_001124526
984:
963:
944:NP_001269312
940:NP_001269311
920:NM_001362799
912:NM_001131054
909:
891:NM_001282383
887:NM_001282382
880:
856:
833:
807:
788:
762:
743:
723:
718:
459:otic placode
423:ciliary body
377:right testis
335:
328:
193:160,428,739
180:160,421,855
55:External IDs
18:
966:NP_004210.1
393:bone marrow
369:left testis
294:43,317,078
281:43,311,077
33:Identifiers
1192:, May 2017
1171:, May 2017
1148:References
1140:Regulation
644:DNA repair
634:cell cycle
339:(ortholog)
76:HomoloGene
991:NP_038945
948:NP_004210
916:NM_013917
883:NM_004219
709:Orthologs
578:cytoplasm
84:GeneCards
2308:Category
2296:12213878
2261:18316557
2253:12194817
2210:11420259
2202:11553328
2159:16188959
2151:11371342
2116:11238996
2073:11179223
2030:11158059
1995:10781616
1960:21958836
1952:10656688
1930:Oncogene
1917:10580151
1888:10411507
1859:38980080
1851:10393434
1822:22575138
1814:10365261
1779:10022450
1744:28589466
1672:16809406
1629:15281346
1584:22704958
1548:21958836
1540:10656688
1518:Oncogene
1499:10781616
1450:12355087
1414:11238996
1269:24151303
1241:Oncogene
1188:–
1167:–
1103:interact
1088:Function
1043:Wikidata
688:Sources:
2231:Bibcode
2180:Bibcode
1868:Science
1736:9925941
1707:9915854
1663:1483889
1458:1770399
1365:9915854
1304:9892021
1261:9811450
1190:Ensembl
1169:Ensembl
1127:PTTG1IP
1075:protein
1071:Securin
821:UniProt
776:Ensembl
715:Species
694:QuickGO
588:cytosol
583:nucleus
314:pattern
72:1353578
40:Aliases
2294:
2259:
2251:
2208:
2200:
2157:
2149:
2114:
2104:
2071:
2064:145417
2061:
2028:
1993:
1958:
1950:
1915:
1886:
1857:
1849:
1820:
1812:
1777:
1742:
1734:
1705:
1670:
1660:
1627:
1617:
1582:
1546:
1538:
1497:
1456:
1448:
1412:
1402:
1363:
1302:
1267:
1259:
1129:, and
1110:DNAJA1
1105:with:
1029:search
1027:PubMed
858:Q9CQJ7
839:Q6IAL9
835:O95997
731:Entrez
485:BioGPS
431:zygote
172:5q33.3
64:604147
2257:S2CID
2206:S2CID
2155:S2CID
2107:29753
1956:S2CID
1855:S2CID
1818:S2CID
1740:S2CID
1544:S2CID
1454:S2CID
1405:29753
1265:S2CID
1133:RPS10
1079:PTTG1
1073:is a
764:30939
724:Mouse
719:Human
690:Amigo
455:ankle
447:blood
381:sperm
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
88:PTTG1
47:PTTG1
24:PTTG1
2292:PMID
2249:PMID
2198:PMID
2147:PMID
2129:Cell
2112:PMID
2069:PMID
2026:PMID
1991:PMID
1948:PMID
1913:PMID
1897:Gene
1884:PMID
1847:PMID
1810:PMID
1775:PMID
1732:PMID
1703:PMID
1668:PMID
1625:PMID
1615:ISBN
1580:PMID
1536:PMID
1495:PMID
1446:PMID
1410:PMID
1361:PMID
1300:PMID
1257:PMID
1116:Ku70
1082:gene
745:9232
443:iris
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
80:3110
60:OMIM
2282:doi
2239:doi
2188:doi
2137:doi
2133:105
2102:PMC
2094:doi
2059:PMC
2051:doi
2016:doi
1981:doi
1977:275
1938:doi
1905:doi
1901:240
1876:doi
1872:285
1839:doi
1800:doi
1765:doi
1724:doi
1693:doi
1689:274
1658:PMC
1650:doi
1607:doi
1572:doi
1526:doi
1485:doi
1481:275
1438:doi
1400:PMC
1392:doi
1351:doi
1347:274
1292:doi
1249:doi
1121:P53
290:End
189:End
92:OMA
68:MGI
2310::
2290:.
2278:87
2276:.
2272:.
2255:.
2247:.
2237:.
2227:12
2225:.
2221:.
2204:.
2196:.
2186:.
2176:11
2174:.
2170:.
2153:.
2145:.
2131:.
2127:.
2110:.
2100:.
2090:29
2088:.
2084:.
2067:.
2057:.
2047:20
2045:.
2041:.
2024:.
2012:86
2010:.
2006:.
1989:.
1975:.
1971:.
1954:.
1946:.
1934:19
1932:.
1928:.
1911:.
1899:.
1882:.
1870:.
1853:.
1845:.
1835:84
1833:.
1816:.
1808:.
1796:47
1794:.
1790:.
1773:.
1761:84
1759:.
1755:.
1738:.
1730:.
1720:83
1718:.
1701:.
1687:.
1683:.
1666:.
1656:.
1644:.
1640:.
1623:.
1613:.
1578:.
1568:84
1566:.
1542:.
1534:.
1522:19
1520:.
1516:.
1493:.
1479:.
1475:.
1452:.
1444:.
1434:32
1432:.
1408:.
1398:.
1388:29
1386:.
1382:.
1359:.
1345:.
1341:.
1329:^
1312:^
1298:.
1288:13
1286:.
1263:.
1255:.
1245:17
1243:.
1223:.
1205:.
1176:^
1155:^
1084:.
692:/
296:bp
283:bp
195:bp
182:bp
90:;
86::
82:;
78::
74:;
70::
66:;
62::
2298:.
2284::
2263:.
2241::
2233::
2212:.
2190::
2182::
2161:.
2139::
2118:.
2096::
2075:.
2053::
2032:.
2018::
1997:.
1983::
1962:.
1940::
1919:.
1907::
1890:.
1878::
1861:.
1841::
1824:.
1802::
1781:.
1767::
1746:.
1726::
1709:.
1695::
1674:.
1652::
1646:4
1631:.
1609::
1586:.
1574::
1550:.
1528::
1501:.
1487::
1460:.
1440::
1416:.
1394::
1367:.
1353::
1323:.
1306:.
1294::
1271:.
1251::
1227:.
1209:.
1135:.
1123:,
1112:,
214:)
111:)
94::
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