Knowledge

Parvalbumin

Source πŸ“

320: 297: 1180: 194: 219: 1200: 326: 225: 61: 1148:. Typically, this protein is broken into three domains, domains AB, CD and EF, each individually containing a helix-loop-helix motif. The AB domain houses a two amino-acid deletion in the loop region, whereas domains CD and EF contain the N-terminal and C-terminal, respectively. 1357:
This way, while muscle contraction is driven by Ca release, muscle relaxation is driven by Ca removal from sarcoplasm. Along with Ca pumps, PV contributes to Ca removal from cytoplasm: PV binds to Ca ions in the sarcoplasm, and then shuttles it to the sarcoplasmic reticulum.
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Schwaller B, Meyer M, Schiffmann S (December 2002). "'New' functions for 'old' proteins: the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice".
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CondΓ© F, Lund JS, Jacobowitz DM, Baimbridge KG, Lewis DA (March 1994). "Local circuit neurons immunoreactive for calretinin, calbindin D-28k or parvalbumin in monkey prefrontal cortex: distribution and morphology".
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Fernandes TJ, Costa J, Carrapatoso I, Oliveira MB, Mafra I (October 2017). "Advances on the molecular characterization, clinical relevance, and detection methods of Gadiform parvalbumin allergens".
1167:. Therefore, calcium-binding proteins must distinguish calcium in the presence of high concentrations of other metal ions. The mechanism for the calcium selectivity has been extensively studied. 2251:
Sharp MF, Stephen JN, Kraft L, Weiss T, Kamath SD, Lopata AL (February 2015). "Immunological cross-reactivity between four distant parvalbumins-Impact on allergen detection and diagnostics".
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Gabbott PL, Bacon SJ (January 1996). "Local circuit neurons in the medial prefrontal cortex (areas 24a, b, c, 25 and 32) in the monkey: II. Quantitative areal and laminar distributions".
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Baig I, Bertini I, Del Bianco C, Gupta YK, Lee YM, Luchinat C, Quattrone A (May 2004). "Paramagnetism-based refinement strategy for the solution structure of human alpha-parvalbumin".
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The protein was discovered in 1965 as a component of the fast-twitching white muscle of fish. It was described as a low molecular-weight "albumin". It is unknown who coined the term
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Leung NY, Wai CY, Shu S, Wang J, Kenny TP, Chu KH, Leung PS (June 2014). "Current immunological and molecular biological perspectives on seafood allergy: a comprehensive review".
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Stephen JN, Sharp MF, Ruethers T, Taki A, Campbell DE, Lopata AL (March 2017). "Allergenicity of bony and cartilaginous fish - molecular and immunological properties".
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Klausberger T, Marton LF, O'Neill J, Huck JH, Dalezios Y, Fuentealba P, Suen WY, Papp E, Kaneko T, Watanabe M, Csicsvari J, Somogyi P (October 2005).
2331:"Carp Myogens of White and Red Muscles. General Composition and Isolation of Low-Molecular-Weight Components of Abnormal Amino Acid Composition" 2966: 1489: 58: 1611:
Dudev T, Lim C (January 2014). "Competition among metal ions for protein binding sites: determinants of metal ion selectivity in proteins".
1471: 2976: 319: 1842: 1141:. Parvalbumin is found in fast-contracting muscles, where its levels are highest, as well as in the brain and some endocrine tissues. 998: 1005: 296: 1995: 1646:
Cowan RL, Wilson CJ, Emson PC, Heizmann CW (December 1990). "Parvalbumin-containing GABAergic interneurons in the rat neostriatum".
1250:, PV+ interneurons are subdivided into basket, axo-axonic, and bistratified cells, each subtype targeting distinct compartments of 2011:
Arif SH (April 2009). "A Ca(2+)-binding protein with numerous roles and uses: parvalbumin in molecular biology and physiology".
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Celio MR, Heizmann CW (June 1982). "Calcium-binding protein parvalbumin is associated with fast contracting muscle fibres".
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PV interneurons' connections are mostly perisomatic (around the cell body of neurons). Most of the PV interneurons are fast-
1735:"Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations" 1433: 2654: 135: 1151:
Calcium binding proteins like parvalbumin play a role in many physiological processes, namely cell-cycle regulation,
332: 231: 1572:"Metal-ion affinity and specificity in EF-hand proteins: coordination geometry and domain plasticity in parvalbumin" 2462: 1187: 325: 224: 2918: 2056:"Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia" 2529: 2419: 819: 143: 2812: 2589: 1354:. The displacement of tropomyosin exposes the myosin-binding sites on actin, permitting muscle contraction. 800: 796: 1335: 2615: 1144:
Parvalbumin is a small, stable protein containing EF-hand type calcium binding sites. It is involved in
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Hashimoto T, Volk DW, Eggan SM, Mirnics K, Pierri JN, Sun Z, Sampson AR, Lewis DA (July 2003).
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in the nervous system, especially the reticular thalamus, and expressed predominantly by
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such as sharks and rays manifest Ξ±-parvalbumin; allergenicity to bony fishes has a low
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Nakazawa K, Zsiros V, Jiang Z, Nakao K, Kolata S, Zhang S, Belforte JE (March 2012).
1925:"Correlation of parvalbumin concentration with relaxation speed in mammalian muscles" 1371: 1243: 590: 2315: 2237: 2181: 2040: 1858: 1719: 1675: 2549: 2493: 1909: 1815: 1750: 1382: 1292: 1288: 1160: 405: 184: 2299: 147: 2264: 1272:
PV-expressing interneurons represent approximately 25% of GABAergic cells in the
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National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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Proceedings of the National Academy of Sciences of the United States of America
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Pechère, JF (January 1968). "Muscular parvalbumins as homologous proteins".
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ENSG00000100362 GRCh38: Ensembl release 89: ENSG00000274665, ENSG00000100362
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10.1002/(SICI)1096-9861(19960122)364:4<609::AID-CNE2>3.0.CO;2-7
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fibers. This function is associated with PV role in calcium sequestration.
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Cates MS, Berry MB, Ho EL, Li Q, Potter JD, Phillips GN (October 1999).
2822: 2765: 2698: 1273: 1130: 1111: 1099: 831: 782: 2439: 2346: 2211: 1624: 1512:"Molecular mechanisms of calcium and magnesium binding to parvalbumin" 92: 88: 84: 80: 2849: 2515: 1893: 1347: 1013: 737: 17: 2454: 1287:. Interneurons are also divided into subgroups by the expression of 2913: 1367: 1351: 1338:, leading to release of Ca in the sarcoplasm. The Ca ions bind to 1198: 1178: 1207:
is expressed in Purkinje cells and molecular layer interneurons.
700: 696: 139: 2458: 2105:"GABAergic interneuron origin of schizophrenia pathophysiology" 1266: 1103: 1102:-binding protein with low molecular weight (typically 9-11 1982:
Alberts B, Johnson, Lewis, Raff, Roberts, Walter (2002).
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Heizmann CW, Berchtold MW, Rowlerson AM (December 1982).
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expression was found in PV+ GABAergic interneurons in
560: 2886: 2858: 2830: 2821: 2778: 2734: 2716: 2669: 2642: 2633: 2598: 2563: 2513: 2504: 2492: 1126:which means "small") and its ability to coagulate. 1077: 1069: 1064: 1059: 970: 937: 907: 882: 1450: 1448: 1446: 1429: 1427: 1425: 1330:membrane. These proteins stimulate the opening of 681:regulation of cytosolic calcium ion concentration 342: 241: 27:Calcium-binding protein with low molecular weight 1510:Cates MS, Teodoro ML, Phillips GN (March 2002). 1283:(most abundant subtype in DLPFC, about 50%) and 2193: 2191: 1565: 1563: 1505: 1503: 1455:GRCm38: Ensembl release 89: ENSMUSG00000005716 2470: 1279:. Other calcium-binding protein markers are 8: 1311:PV is known to be involved in relaxation of 1990:(4th ed.). New York: Garland Science. 2827: 2639: 2510: 2501: 2477: 2463: 2455: 1413:, but the word is already in use by 1967. 711: 586: 383: 282: 179: 69: 2945:disorders of globin and globulin proteins 2418:at the U.S. National Library of Medicine 2354: 2219: 2128: 2079: 1958: 1948: 1758: 1587: 1543: 1246:and molecular layer interneurons. In the 1326:stimulate voltage-sensitive proteins in 1261:. They are also thought to give rise to 2380:Comparative Biochemistry and Physiology 1421: 1377:Parvalbumin has been identified as an 1133:motifs and is structurally related to 1056: 29: 347: 308: 303: 246: 205: 200: 7: 2329:Hamoir, G; Konosu, S (1 July 1965). 1831:The Journal of Comparative Neurology 1788:The Journal of Comparative Neurology 1648:The Journal of Comparative Neurology 1342:, which causes the displacement of 1106:). In humans, it is encoded by the 619:protein heterodimerization activity 519:medial head of gastrocnemius muscle 2072:10.1523/JNEUROSCI.23-15-06315.2003 1114:family; it is named for its size ( 967: 934: 904: 879: 855: 836: 810: 787: 761: 742: 565: 483: 421: 400: 25: 1188:reticular nucleus of the thalamus 609:protein homodimerization activity 2121:10.1016/j.neuropharm.2011.01.022 1203:In the cerebellum of adult mice 331: 324: 318: 295: 230: 223: 217: 192: 1223:Parvalbumin is present in some 1190:in the postnatal day 56 mouse. 2924:Extracellular matrix protein 1 1751:10.1523/JNEUROSCI.3269-05.2005 549:More reference expression data 449:dorsolateral prefrontal cortex 437:right hemisphere of cerebellum 1: 2300:10.1080/10408398.2015.1113157 1988:Molecular Biology of the Cell 1589:10.1016/S0969-2126(00)80060-X 1536:10.1016/S0006-3495(02)75472-6 316: 215: 2967:Genes on human chromosome 22 2655:Sex hormone-binding globulin 2392:10.1016/0010-406x(68)90978-x 2265:10.1016/j.molimm.2014.09.019 1110:gene. It is a member of the 2977:EF-hand-containing proteins 2060:The Journal of Neuroscience 1739:The Journal of Neuroscience 1393:manifest Ξ²-parvalbumin and 2993: 1704:10.1080/147342202320883551 1346:, a protein that prevents 655:protein-containing complex 507:sternocleidomastoid muscle 2936: 2919:Vitamin D-binding protein 2166:10.1007/s12016-012-8336-9 1490:"Mouse PubMed Reference:" 1472:"Human PubMed Reference:" 1401:to cartilaginous fishes. 1044: 1039: 1035: 1028: 1012: 993: 974: 941: 930: 911: 886: 875: 862: 858: 843: 839: 830: 817: 813: 794: 790: 781: 768: 764: 749: 745: 736: 721: 714: 710: 694: 589: 585: 573: 568: 559: 546: 495: 486: 433: 424: 394: 386: 382: 365: 352: 315: 294: 285: 281: 264: 251: 214: 191: 182: 178: 133: 130: 120: 113: 108: 77: 72: 55: 50: 45: 41: 37: 32: 2530:Alpha 1-antichymotrypsin 2420:Medical Subject Headings 2154:Clin Rev Allergy Immunol 1006:Chr 15: 78.08 – 78.09 Mb 527:tibialis anterior muscle 2813:7S seed storage protein 2590:Retinol binding protein 1950:10.1073/pnas.79.23.7243 999:Chr 22: 36.8 – 36.82 Mb 523:vastus lateralis muscle 2972:Molecular neuroscience 2288:Crit Rev Food Sci Nutr 2025:10.1002/bies.200800170 1336:sarcoplasmic reticulum 1238:in the cortex. In the 1211: 1194: 1120: 499:triceps brachii muscle 445:superior frontal gyrus 349:15 E1|15 36.93 cM 126:, D22S749, parvalbumin 2616:alpha-2-Macroglobulin 1800:10.1002/cne.903410109 1660:10.1002/cne.903020202 1362:Clinical significance 1242:, PV is expressed in 1202: 1182: 1171:Location and function 441:primary visual cortex 310:Chromosome 15 (mouse) 208:Chromosome 22 (human) 2873:Bovine serum albumin 2689:Beta-2 microglobulin 1395:cartilaginous fishes 1186:is expressed in the 73:List of PDB id codes 46:Available structures 2868:Human serum albumin 2808:11S globulin family 2554:Heparin cofactor II 2544:Alpha 2-antiplasmin 2534:Alpha 1-antitrypsin 2335:Biochemical Journal 1941:1982PNAS...79.7243H 1886:1982Natur.297..504C 1528:2002BpJ....82.1133C 1516:Biophysical Journal 1209:Allen Brain Atlases 1192:Allen Brain Atlases 686:cochlea development 604:calcium ion binding 2894:C-reactive protein 2786:Beta-lactoglobulin 2200:Clin. Exp. Allergy 1984:"Molecular Motors" 1320:muscle contraction 1313:fast-twitch muscle 1307:In muscular tissue 1212: 1195: 1159:, organization of 1157:muscle contraction 820:ENSMUSG00000005716 674:Biological process 645:neuronal cell body 628:Cellular component 597:Molecular function 453:right frontal lobe 2954: 2953: 2932: 2931: 2903:Alpha-lactalbumin 2803:Alpha-lactalbumin 2774: 2773: 2746:Fetal fibronectin 2712: 2711: 2629: 2628: 2486:Globular proteins 2440:10.1021/bi035879k 2347:10.1042/bj0960085 2212:10.1111/cea.12892 2109:Neuropharmacology 1625:10.1021/cr4004665 1387:shellfish allergy 1366:Decreased PV and 1216: 1215: 1165:phototransduction 1146:calcium signaling 1089: 1088: 1055: 1054: 1051: 1050: 1024: 1023: 989: 988: 964: 963: 926: 925: 901: 900: 871: 870: 852: 851: 826: 825: 807: 806: 777: 776: 758: 757: 706: 705: 614:metal ion binding 581: 580: 577: 576: 555: 554: 542: 541: 480: 479: 378: 377: 277: 276: 172:PVALB - orthologs 104: 103: 100: 99: 56:Ortholog search: 16:(Redirected from 2984: 2828: 2672: 2648: 2645:carrier proteins 2640: 2601: 2569: 2566:carrier proteins 2519: 2511: 2502: 2479: 2472: 2465: 2456: 2451: 2404: 2403: 2375: 2369: 2368: 2358: 2326: 2320: 2319: 2294:(15): 3281–296. 2283: 2277: 2276: 2248: 2242: 2241: 2223: 2195: 2186: 2185: 2149: 2143: 2142: 2132: 2100: 2094: 2093: 2083: 2051: 2045: 2044: 2008: 2002: 2001: 1979: 1973: 1972: 1962: 1952: 1920: 1914: 1913: 1894:10.1038/297504a0 1869: 1863: 1862: 1826: 1820: 1819: 1782: 1776: 1772: 1762: 1730: 1724: 1723: 1686: 1680: 1679: 1643: 1637: 1636: 1613:Chemical Reviews 1608: 1602: 1601: 1591: 1567: 1558: 1557: 1547: 1507: 1498: 1497: 1486: 1480: 1479: 1468: 1462: 1452: 1441: 1431: 1399:cross-reactivity 1324:action potential 1219:In neural tissue 1175: 1174: 1153:second messenger 1057: 1037: 1036: 1008: 1001: 984: 968: 959: 935: 931:RefSeq (protein) 921: 905: 896: 880: 856: 837: 811: 788: 762: 743: 712: 587: 566: 551: 511:digastric muscle 491: 489:Top expressed in 484: 465:substantia nigra 429: 427:Top expressed in 422: 401: 384: 374: 361: 350: 335: 328: 322: 311: 299: 283: 273: 260: 249: 234: 227: 221: 210: 196: 180: 174: 125: 118: 95: 70: 64: 43: 42: 30: 21: 2992: 2991: 2987: 2986: 2985: 2983: 2982: 2981: 2957: 2956: 2955: 2950: 2949: 2928: 2882: 2854: 2817: 2779:Other globulins 2770: 2730: 2726:Immunoglobulins 2708: 2670: 2665: 2662: 2643: 2625: 2599: 2594: 2564: 2559: 2514: 2506:Alpha globulins 2488: 2483: 2434:(18): 5562–73. 2425: 2412: 2407: 2377: 2376: 2372: 2328: 2327: 2323: 2285: 2284: 2280: 2250: 2249: 2245: 2197: 2196: 2189: 2151: 2150: 2146: 2102: 2101: 2097: 2066:(15): 6315–26. 2053: 2052: 2048: 2010: 2009: 2005: 1998: 1981: 1980: 1976: 1922: 1921: 1917: 1880:(5866): 504–6. 1871: 1870: 1866: 1828: 1827: 1823: 1784: 1783: 1779: 1745:(42): 9782–93. 1732: 1731: 1727: 1688: 1687: 1683: 1645: 1644: 1640: 1610: 1609: 1605: 1582:(10): 1269–78. 1569: 1568: 1561: 1509: 1508: 1501: 1488: 1487: 1483: 1470: 1469: 1465: 1453: 1444: 1432: 1423: 1419: 1407: 1364: 1309: 1301:cholecystokinin 1252:pyramidal cells 1221: 1173: 1046:View/Edit Mouse 1041:View/Edit Human 1004: 997: 994:Location (UCSC) 980: 976: 955: 951: 947: 943: 917: 913: 892: 888: 801:ENSG00000100362 799: 797:ENSG00000274665 690: 669: 665:cuticular plate 623: 547: 538: 533: 529: 525: 521: 517: 515:muscle of thigh 513: 509: 505: 503:temporal muscle 501: 487: 476: 471: 469:Brodmann area 9 467: 463: 459: 457:muscle of thigh 455: 451: 447: 443: 439: 425: 369: 356: 348: 338: 337: 336: 329: 309: 286:Gene location ( 268: 255: 247: 237: 236: 235: 228: 206: 183:Gene location ( 134: 121: 114: 79: 57: 28: 23: 22: 15: 12: 11: 5: 2990: 2988: 2980: 2979: 2974: 2969: 2959: 2958: 2952: 2951: 2948: 2947: 2938: 2937: 2934: 2933: 2930: 2929: 2927: 2926: 2921: 2916: 2911: 2906: 2896: 2890: 2888: 2884: 2883: 2881: 2880: 2875: 2870: 2864: 2862: 2856: 2855: 2853: 2852: 2847: 2842: 2836: 2834: 2825: 2819: 2818: 2816: 2815: 2810: 2805: 2800: 2795: 2794: 2793: 2782: 2780: 2776: 2775: 2772: 2771: 2769: 2768: 2763: 2761:Transcobalamin 2758: 2749: 2738: 2736: 2732: 2731: 2729: 2728: 2722: 2720: 2718:Gamma globulin 2714: 2713: 2710: 2709: 2707: 2706: 2701: 2696: 2691: 2686: 2681: 2675: 2673: 2667: 2666: 2664: 2663: 2657: 2651: 2649: 2637: 2635:Beta globulins 2631: 2630: 2627: 2626: 2624: 2623: 2612: 2604: 2602: 2596: 2595: 2593: 2592: 2587: 2580: 2572: 2570: 2561: 2560: 2558: 2557: 2547: 2537: 2522: 2520: 2508: 2499: 2490: 2489: 2484: 2482: 2481: 2474: 2467: 2459: 2453: 2452: 2423: 2411: 2410:External links 2408: 2406: 2405: 2370: 2321: 2278: 2243: 2187: 2144: 2115:(3): 1574–83. 2095: 2046: 2003: 1996: 1974: 1935:(23): 7243–7. 1915: 1864: 1821: 1777: 1774:free full text 1725: 1681: 1654:(2): 197–205. 1638: 1603: 1559: 1522:(3): 1133–46. 1499: 1481: 1463: 1442: 1420: 1418: 1415: 1406: 1403: 1363: 1360: 1350:walking along 1308: 1305: 1297:neuropeptide Y 1244:Purkinje cells 1220: 1217: 1214: 1213: 1196: 1172: 1169: 1087: 1086: 1081: 1075: 1074: 1071: 1067: 1066: 1062: 1061: 1053: 1052: 1049: 1048: 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278: 275: 274: 266: 262: 261: 253: 250: 245: 239: 238: 229: 222: 216: 212: 211: 204: 198: 197: 189: 188: 176: 175: 132: 128: 127: 119: 111: 110: 106: 105: 102: 101: 98: 97: 75: 74: 66: 65: 54: 48: 47: 39: 38: 35: 34: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 2989: 2978: 2975: 2973: 2970: 2968: 2965: 2964: 2962: 2946: 2943: 2940: 2939: 2935: 2925: 2922: 2920: 2917: 2915: 2912: 2910: 2907: 2904: 2900: 2897: 2895: 2892: 2891: 2889: 2885: 2879: 2876: 2874: 2871: 2869: 2866: 2865: 2863: 2861: 2860:Serum albumin 2857: 2851: 2848: 2846: 2843: 2841: 2838: 2837: 2835: 2833: 2829: 2826: 2824: 2820: 2814: 2811: 2809: 2806: 2804: 2801: 2799: 2798:Thyroglobulin 2796: 2792: 2789: 2788: 2787: 2784: 2783: 2781: 2777: 2767: 2764: 2762: 2759: 2757: 2756:Microglobulin 2753: 2752:Macroglobulin 2750: 2747: 2743: 2740: 2739: 2737: 2733: 2727: 2724: 2723: 2721: 2719: 2715: 2705: 2702: 2700: 2697: 2695: 2692: 2690: 2687: 2685: 2682: 2680: 2677: 2676: 2674: 2668: 2661: 2658: 2656: 2653: 2652: 2650: 2646: 2641: 2638: 2636: 2632: 2621: 2617: 2613: 2610: 2606: 2605: 2603: 2597: 2591: 2588: 2585: 2584:Ceruloplasmin 2581: 2578: 2574: 2573: 2571: 2567: 2562: 2555: 2551: 2548: 2545: 2541: 2538: 2535: 2531: 2527: 2524: 2523: 2521: 2517: 2512: 2509: 2507: 2503: 2500: 2498: 2495: 2491: 2487: 2480: 2475: 2473: 2468: 2466: 2461: 2460: 2457: 2449: 2445: 2441: 2437: 2433: 2429: 2424: 2421: 2417: 2414: 2413: 2409: 2401: 2397: 2393: 2389: 2386:(1): 289–95. 2385: 2381: 2374: 2371: 2366: 2362: 2357: 2352: 2348: 2344: 2340: 2336: 2332: 2325: 2322: 2317: 2313: 2309: 2305: 2301: 2297: 2293: 2289: 2282: 2279: 2274: 2270: 2266: 2262: 2259:(2): 437–48. 2258: 2254: 2247: 2244: 2239: 2235: 2231: 2227: 2222: 2217: 2213: 2209: 2206:(3): 300–12. 2205: 2201: 2194: 2192: 2188: 2183: 2179: 2175: 2171: 2167: 2163: 2160:(3): 180–97. 2159: 2155: 2148: 2145: 2140: 2136: 2131: 2126: 2122: 2118: 2114: 2110: 2106: 2099: 2096: 2091: 2087: 2082: 2077: 2073: 2069: 2065: 2061: 2057: 2050: 2047: 2042: 2038: 2034: 2030: 2026: 2022: 2019:(4): 410–21. 2018: 2014: 2007: 2004: 1999: 1997:0-8153-3218-1 1993: 1989: 1985: 1978: 1975: 1970: 1966: 1961: 1956: 1951: 1946: 1942: 1938: 1934: 1930: 1926: 1919: 1916: 1911: 1907: 1903: 1899: 1895: 1891: 1887: 1883: 1879: 1875: 1868: 1865: 1860: 1856: 1852: 1848: 1844: 1840: 1837:(4): 609–36. 1836: 1832: 1825: 1822: 1817: 1813: 1809: 1805: 1801: 1797: 1794:(1): 95–116. 1793: 1789: 1781: 1778: 1775: 1770: 1766: 1761: 1756: 1752: 1748: 1744: 1740: 1736: 1729: 1726: 1721: 1717: 1713: 1709: 1705: 1701: 1698:(4): 241–58. 1697: 1693: 1685: 1682: 1677: 1673: 1669: 1665: 1661: 1657: 1653: 1649: 1642: 1639: 1634: 1630: 1626: 1622: 1619:(1): 538–56. 1618: 1614: 1607: 1604: 1599: 1595: 1590: 1585: 1581: 1577: 1573: 1566: 1564: 1560: 1555: 1551: 1546: 1541: 1537: 1533: 1529: 1525: 1521: 1517: 1513: 1506: 1504: 1500: 1495: 1491: 1485: 1482: 1477: 1473: 1467: 1464: 1460: 1456: 1451: 1449: 1447: 1443: 1439: 1435: 1430: 1428: 1426: 1422: 1416: 1414: 1412: 1404: 1402: 1400: 1396: 1392: 1388: 1384: 1380: 1375: 1373: 1372:schizophrenia 1369: 1361: 1359: 1355: 1353: 1349: 1345: 1341: 1337: 1333: 1329: 1325: 1321: 1316: 1314: 1306: 1304: 1302: 1298: 1294: 1290: 1289:neuropeptides 1286: 1282: 1278: 1275: 1270: 1268: 1264: 1260: 1255: 1253: 1249: 1245: 1241: 1237: 1233: 1229: 1226: 1218: 1210: 1206: 1201: 1197: 1193: 1189: 1185: 1181: 1177: 1176: 1170: 1168: 1166: 1162: 1158: 1154: 1149: 1147: 1142: 1140: 1136: 1132: 1129:It has three 1127: 1125: 1124: 1123: 1118:, from Latin 1117: 1113: 1109: 1105: 1101: 1097: 1093: 1085: 1082: 1080: 1076: 1072: 1068: 1063: 1058: 1047: 1042: 1038: 1034: 1031: 1027: 1020: 1018: 1015: 1011: 1007: 1003: 1000: 996: 992: 985: 983: 979: 973: 969: 966: 960: 958: 954: 950: 946: 940: 936: 933: 929: 922: 920: 916: 910: 906: 903: 897: 895: 891: 885: 881: 878: 876:RefSeq (mRNA) 874: 867: 866: 861: 857: 854: 848: 847: 842: 838: 835: 833: 829: 822: 821: 816: 812: 809: 803: 802: 798: 793: 789: 786: 784: 780: 773: 772: 767: 763: 760: 754: 753: 748: 744: 741: 739: 735: 732: 729: 727: 724: 720: 717: 713: 709: 702: 698: 693: 687: 684: 682: 679: 678: 676: 673: 672: 666: 663: 661: 658: 656: 653: 651: 648: 646: 643: 641: 638: 636: 633: 632: 630: 627: 626: 620: 617: 615: 612: 610: 607: 605: 602: 601: 599: 596: 595: 592: 591:Gene ontology 588: 584: 572: 567: 564: 562: 558: 550: 545: 534: 530: 526: 522: 518: 514: 510: 506: 502: 498: 497: 494: 490: 485: 482: 472: 468: 464: 460: 456: 452: 448: 444: 440: 436: 435: 432: 428: 423: 420: 419: 416: 414: 410: 408: 407: 403: 402: 399: 397: 393: 389: 385: 381: 373: 368: 364: 360: 355: 345: 341: 334: 327: 321: 314: 306: 302: 298: 293: 289: 284: 280: 272: 267: 263: 259: 254: 244: 240: 233: 226: 220: 213: 209: 203: 199: 195: 190: 186: 181: 177: 173: 169: 165: 161: 157: 153: 149: 145: 141: 137: 129: 124: 117: 112: 107: 96: 94: 90: 86: 82: 76: 71: 68: 67: 63: 60: 53: 49: 44: 40: 36: 31: 19: 2941: 2908: 2550:Antithrombin 2431: 2428:Biochemistry 2427: 2416:Parvalbumins 2383: 2379: 2373: 2341:(1): 85–97. 2338: 2334: 2324: 2291: 2287: 2281: 2256: 2253:Mol. Immunol 2252: 2246: 2221:11343/292433 2203: 2199: 2157: 2153: 2147: 2112: 2108: 2098: 2063: 2059: 2049: 2016: 2012: 2006: 1987: 1977: 1932: 1928: 1918: 1877: 1873: 1867: 1834: 1830: 1824: 1791: 1787: 1780: 1742: 1738: 1728: 1695: 1691: 1684: 1651: 1647: 1641: 1616: 1612: 1606: 1579: 1575: 1519: 1515: 1493: 1484: 1475: 1466: 1410: 1408: 1383:fish allergy 1376: 1365: 1356: 1317: 1310: 1293:somatostatin 1271: 1265:recorded in 1256: 1236:basket cells 1228:interneurons 1222: 1161:microtubules 1155:production, 1150: 1143: 1128: 1119: 1115: 1107: 1095: 1091: 1090: 978:NP_001317615 975: 945:NP_001302461 942: 919:NM_001330686 912: 894:NM_001315532 887: 863: 844: 818: 795: 769: 750: 730: 725: 660:stereocilium 461:human kidney 411: 404: 131:External IDs 78: 2909:Parvalbumin 2899:Lactalbumin 2791:Lactoferrin 2742:Fibronectin 2699:Plasminogen 2679:Angiostatin 2660:Transferrin 2620:Haptoglobin 2609:Orosomucoid 2577:Transcortin 1411:parvalbumin 1391:Bony fishes 1344:tropomyosin 1332:Ca channels 1263:gamma waves 1248:hippocampus 1092:Parvalbumin 1065:Identifiers 1060:Parvalbumin 957:NP_002845.1 531:ankle joint 370:78,090,600 357:78,075,314 269:36,819,479 256:36,800,684 109:Identifiers 2961:Categories 2878:Prealbumin 2840:Conalbumin 1692:Cerebellum 1461:, May 2017 1440:, May 2017 1417:References 1281:calretinin 1240:cerebellum 1232:chandelier 1139:troponin C 1135:calmodulin 473:C1 segment 415:(ortholog) 152:HomoloGene 2845:Ovalbumin 2832:Egg white 2704:Properdin 2684:Hemopexin 2614:alpha-2 ( 2607:alpha-1 ( 2582:alpha-2 ( 2575:alpha-1 ( 2497:globulins 2013:BioEssays 1576:Structure 1385:(but not 1328:T-tubules 1285:calbindin 1225:GABAergic 1084:IPR008080 982:NP_038673 949:NP_002845 915:NM_013645 890:NM_002854 716:Orthologs 635:cytoplasm 160:GeneCards 2942:see also 2823:Albumins 2694:Factor H 2448:15122922 2365:14343157 2316:22118352 2308:26714098 2273:25451973 2238:22539836 2230:28117510 2182:29615377 2174:23242979 2139:21277876 2090:12867516 2041:42448973 2033:19274659 1859:27397665 1769:16237182 1720:25917565 1712:12879963 1676:38540563 1633:24040963 1598:10545326 1554:11867433 1457:– 1436:– 1381:causing 1379:allergen 1340:troponin 1291:such as 1079:InterPro 1030:Wikidata 695:Sources: 2766:Edestin 2540:alpha-2 2526:alpha-1 2516:serpins 2400:5645516 2356:1206910 2130:3090452 2081:6740534 1969:6961404 1937:Bibcode 1910:4360112 1902:6211622 1882:Bibcode 1851:8821450 1816:2583429 1808:8006226 1760:6725722 1668:2289971 1545:1301919 1524:Bibcode 1459:Ensembl 1438:Ensembl 1405:History 1334:in the 1318:During 1274:primate 1259:spiking 1131:EF hand 1112:albumin 1100:calcium 1098:) is a 832:UniProt 783:Ensembl 722:Species 701:QuickGO 650:nucleus 390:pattern 248:22q12.3 116:Aliases 2850:Avidin 2744:(fFN: 2671:other: 2600:other: 2446:  2422:(MeSH) 2398:  2363:  2353:  2314:  2306:  2271:  2236:  2228:  2180:  2172:  2137:  2127:  2088:  2078:  2039:  2031:  1994:  1967:  1960:347315 1957:  1908:  1900:  1874:Nature 1857:  1849:  1814:  1806:  1767:  1757:  1718:  1710:  1674:  1666:  1631:  1596:  1552:  1542:  1348:myosin 1322:, the 1122:parvus 1070:Symbol 1016:search 1014:PubMed 865:P32848 846:P20472 738:Entrez 561:BioGPS 140:168890 2914:Ricin 2887:Other 2735:Other 2494:Serum 2312:S2CID 2234:S2CID 2178:S2CID 2037:S2CID 1906:S2CID 1855:S2CID 1812:S2CID 1716:S2CID 1672:S2CID 1368:GAD67 1352:actin 1277:DLPFC 1205:Pvalb 1184:Pvalb 1116:parv- 1108:PVALB 771:19293 731:Mouse 726:Human 697:Amigo 535:ankle 413:Mouse 406:Human 353:Start 288:Mouse 252:Start 185:Human 164:PVALB 148:97821 123:PVALB 33:PVALB 18:PVALB 2444:PMID 2396:PMID 2361:PMID 2304:PMID 2269:PMID 2226:PMID 2170:PMID 2135:PMID 2086:PMID 2029:PMID 1992:ISBN 1965:PMID 1898:PMID 1847:PMID 1804:PMID 1765:PMID 1708:PMID 1664:PMID 1629:PMID 1594:PMID 1550:PMID 1234:and 1163:and 1137:and 752:5816 640:axon 396:Bgee 344:Band 305:Chr. 243:Band 202:Chr. 156:2137 136:OMIM 93:1RJV 89:1RK9 87:,%%s 85:1RK9 81:1RJV 62:RCSB 59:PDBe 2436:doi 2388:doi 2351:PMC 2343:doi 2296:doi 2261:doi 2216:hdl 2208:doi 2162:doi 2125:PMC 2117:doi 2076:PMC 2068:doi 2021:doi 1955:PMC 1945:doi 1890:doi 1878:297 1839:doi 1835:364 1796:doi 1792:341 1755:PMC 1747:doi 1700:doi 1656:doi 1652:302 1621:doi 1617:114 1584:doi 1540:PMC 1532:doi 1389:). 1267:EEG 1104:kDa 569:n/a 366:End 265:End 168:OMA 144:MGI 52:PDB 2963:: 2618:, 2532:, 2442:. 2432:43 2430:. 2394:. 2384:24 2382:. 2359:. 2349:. 2339:96 2337:. 2333:. 2310:. 2302:. 2292:57 2290:. 2267:. 2257:63 2255:. 2232:. 2224:. 2214:. 2204:47 2202:. 2190:^ 2176:. 2168:. 2158:46 2156:. 2133:. 2123:. 2113:62 2111:. 2107:. 2084:. 2074:. 2064:23 2062:. 2058:. 2035:. 2027:. 2017:31 2015:. 1986:. 1963:. 1953:. 1943:. 1933:79 1931:. 1927:. 1904:. 1896:. 1888:. 1876:. 1853:. 1845:. 1833:. 1810:. 1802:. 1790:. 1763:. 1753:. 1743:25 1741:. 1737:. 1714:. 1706:. 1694:. 1670:. 1662:. 1650:. 1627:. 1615:. 1592:. 1578:. 1574:. 1562:^ 1548:. 1538:. 1530:. 1520:82 1518:. 1514:. 1502:^ 1492:. 1474:. 1445:^ 1424:^ 1374:. 1303:. 1299:, 1295:, 1269:. 1254:. 1096:PV 699:/ 372:bp 359:bp 271:bp 258:bp 166:; 162:: 158:; 154:: 150:; 146:: 142:; 138:: 91:, 83:, 2905:) 2901:( 2754:/ 2748:) 2647:: 2622:) 2611:) 2586:) 2579:) 2568:: 2556:) 2552:( 2546:) 2542:( 2536:) 2528:( 2518:: 2478:e 2471:t 2464:v 2450:. 2438:: 2402:. 2390:: 2367:. 2345:: 2318:. 2298:: 2275:. 2263:: 2240:. 2218:: 2210:: 2184:. 2164:: 2141:. 2119:: 2092:. 2070:: 2043:. 2023:: 2000:. 1971:. 1947:: 1939:: 1912:. 1892:: 1884:: 1861:. 1841:: 1818:. 1798:: 1771:. 1749:: 1722:. 1702:: 1696:1 1678:. 1658:: 1635:. 1623:: 1600:. 1586:: 1580:7 1556:. 1534:: 1526:: 1496:. 1478:. 1094:( 1073:? 290:) 187:) 170:: 20:)

Index

PVALB
PDB
PDBe
RCSB
1RJV
1RK9
1RK9
1RJV
Aliases
PVALB
OMIM
168890
MGI
97821
HomoloGene
2137
GeneCards
PVALB
OMA
PVALB - orthologs
Human
Chromosome 22 (human)
Chr.
Chromosome 22 (human)
Chromosome 22 (human)
Genomic location for PVALB
Genomic location for PVALB
Band
bp
bp

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