244:
221:
118:
143:
495:
250:
149:
1053:
1175:
of OCA2 is involved in the light skin tone and the derived allele is restricted to East Asia with high frequencies, with highest frequencies in
Eastern East Asia (49-63%), midrange frequencies in Southeast Asia, and the lowest frequencies in Western China and some Eastern European populations.
1500:
Eiberg H, Troelsen J, Nielsen M, Mikkelsen A, Mengel-From J, Kjaer KW, et al. (March 2008). "Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression".
1146:. The prevalence of OCA type 2 is estimated at 1/38,000-1/40,000 in most populations throughout the world, with a higher prevalence in the African population of 1/3,900–1/1,500. Other diseases associated with the deletion of the OCA2 gene are
2340:
Toyofuku K, Valencia JC, Kushimoto T, Costin GE, Virador VM, Vieira WD, et al. (June 2002). "The etiology of oculocutaneous albinism (OCA) type II: the pink protein modulates the processing and transport of tyrosinase".
1956:
Lee ST, Nicholls RD, Schnur RE, Guida LC, Lu-Kuo J, Spinner NB, et al. (November 1994). "Diverse mutations of the P gene among
African-Americans with type II (tyrosinase-positive) oculocutaneous albinism (OCA2)".
1978:
Durham-Pierre D, Gardner JM, Nakatsu Y, King RA, Francke U, Ching A, et al. (June 1994). "African origin of an intragenic deletion of the human P gene in tyrosinase positive oculocutaneous albinism".
2051:
Rinchik EM, Bultman SJ, Horsthemke B, Lee ST, Strunk KM, Spritz RA, et al. (January 1993). "A gene for the mouse pink-eyed dilution locus and for human type II oculocutaneous albinism".
1084:. Melanin is responsible for giving color to the skin, hair, and eyes. Moreover, melanin is found in the light-sensitive tissue of the retina of the eye which plays a role in normal vision.
1810:
Gardner JM, Nakatsu Y, Gondo Y, Lee S, Lyon MF, King RA, et al. (August 1992). "The mouse pink-eyed dilution gene: association with human Prader-Willi and
Angelman syndromes".
2260:
1892:
Lee ST, Nicholls RD, Jong MT, Fukai K, Spritz RA (March 1995). "Organization and sequence of the human P gene and identification of a new family of transport proteins".
257:
156:
2225:
Passmore LA, Kaesmann-Kellner B, Weber BH (September 1999). "Novel and recurrent mutations in the tyrosinase gene and the P gene in the German albino population".
1644:"Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: further evidence of convergent evolution of skin pigmentation"
2311:
Manga P, Orlow SJ (October 2001). "Inverse correlation between pink-eyed dilution protein expression and induction of melanogenesis by bafilomycin A1".
733:
79:
714:
1064:
The human OCA2 gene is located on the long arm (q) of chromosome 15, specifically from base pair 28,000,020 to base pair 28,344,457 on chromosome 15.
1295:"A chromosome-level genome of Astyanax mexicanus surface fish for comparing population-specific genetic differences contributing to trait evolution"
2392:
1855:
Ludowese CJ, Thompson KJ, Sekhon GS, Pauli RM (September 1991). "Absence of predictable phenotypic expression in proximal 15q duplications".
1252:
1234:
1154:(unusually light-colored hair and fair skin). With both these syndromes, the deletion often occurs in individuals with either syndrome.
1126:
Mutations in the OCA2 gene cause a disruption in the normal production of melanin; therefore, causing vision problems and reductions in
243:
2157:
2140:
945:
2200:
2183:
2114:
2097:
952:
1715:
1698:
220:
1273:
2270:"In Southern Africa, brown oculocutaneous albinism (BOCA) maps to the OCA2 locus on chromosome 15q: P-gene mutations identified"
1221:
1200:
1403:
142:
117:
1217:
1546:"A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color"
2184:"Mutations of the human P gene associated with Type II oculocutaneous albinism (OCA2). Mutations in brief no. 205. Online"
1196:
1103:
production. This gene seems to be the main determinant of eye color depending on the amount of melanin production in the
59:
1471:
1165:. It has been hypothesized that all blue-eyed humans share a single common ancestor with whom the mutation originated.
256:
155:
1081:
1151:
1087:
The exact function of protein P is unknown, but it has been found that it is essential for the normal coloring of
1034:
249:
148:
1161:
gene adjacent to OCA2, affecting OCA2's expression in the human iris, is found common to nearly all people with
50:, BEY, BEY1, BEY2, BOCA, D15S12, EYCL, EYCL2, EYCL3, HCL3, PED, SHEP1, OCA2 melanosomal transmembrane protein, P
1742:"The mouse p (pink-eyed dilution) and human P genes, oculocutaneous albinism type 2 (OCA2), and melanosomal pH"
782:
67:
2018:"Mutations of the P gene in oculocutaneous albinism, ocular albinism, and Prader-Willi syndrome plus albinism"
1923:"Frequent intragenic deletion of the P gene in Tanzanian patients with type II oculocutaneous albinism (OCA2)"
1118:
in cave's individuals. It exists as a deletion in Pachón and Molino's caves fish that produces the albinism.
1139:
1046:
763:
759:
2377:
1699:"Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism"
1351:
2254:
1057:
131:
2141:"Identification of P gene mutations in individuals with oculocutaneous albinism in sub-Saharan Africa"
2060:
1819:
1306:
46:
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91:
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1293:
Warren WC, Boggs TE, Borowsky R, Carlson BM, Ferrufino E, Gross JB, et al. (March 2021).
1147:
39:
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2195:
2152:
2109:
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2029:
1988:
1934:
1901:
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1827:
1788:
1775:
Ramsay M, Colman MA, Stevens G, Zwane E, Kromberg J, Farrall M, et al. (October 1992).
1753:
1710:
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1614:
1606:
1565:
1557:
1510:
1322:
1314:
336:
267:
211:
166:
2096:
Spritz RA, Lee ST, Fukai K, Brondum-Nielsen K, Chitayat D, Lipson MH, et al. (1997).
1544:
Sturm RA, Duffy DL, Zhao ZZ, Leite FP, Stark MS, Hayward NK, et al. (February 2008).
1453:
1107:(large amounts giving rise to brown eyes; little to no melanin giving rise to blue eyes).
494:
311:
87:
2182:
Oetting WS, Gardner JM, Fryer JP, Ching A, Durham-Pierre D, King RA, et al. (1998).
1593:
Donnelly MP, Paschou P, Grigorenko E, Gurwitz D, Barta C, Lu RB, et al. (May 2012).
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1823:
1310:
2294:
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1868:
1793:
1776:
1670:
1643:
1619:
1594:
1570:
1545:
1327:
1294:
1072:
OCA2 provides instructions for making the protein called P protein which is located in
2324:
1777:"The tyrosinase-positive oculocutaneous albinism locus maps to chromosome 15q11.2-q12"
1758:
1741:
648:
643:
638:
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628:
623:
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2008:
1847:
1530:
1411:
329:
108:
1831:
1052:
71:
2016:
Lee ST, Nicholls RD, Bundey S, Laxova R, Musarella M, Spritz RA (February 1994).
1660:
1274:"Entrez Gene: OCA2 oculocutaneous albinism II (pink-eye dilution homolog, mouse)"
95:
2034:
2017:
1257:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1239:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1104:
1642:
Edwards M, Bigham A, Tan J, Li S, Gozdzik A, Ross K, et al. (March 2010).
1561:
1318:
412:
1610:
1514:
1096:
1088:
1073:
1049:. OCA2 encodes the human homologue of the mouse p (pink-eyed dilution) gene.
228:
125:
75:
1479:
1197:
ENSG00000277361 GRCh38: Ensembl release 89: ENSG00000104044, ENSG00000277361
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992:
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2158:
10.1002/(SICI)1098-1004(200002)15:2<166::AID-HUMU5>3.0.CO;2-Z
2098:"Novel mutations of the P gene in type II oculocutaneous albinism (OCA2)"
1356:
1115:
1038:
976:
827:
808:
2201:
10.1002/(SICI)1098-1004(1998)12:6<434::AID-HUMU16>3.0.CO;2-7
2115:
10.1002/(SICI)1098-1004(1997)10:2<175::AID-HUMU12>3.0.CO;2-X
1382:
Genetics Home
Reference - Your guide to understanding genetic conditions
2139:
Kerr R, Stevens G, Manga P, Salm S, John P, Haw T, et al. (2000).
1992:
1100:
1077:
1042:
1016:
794:
745:
1716:
10.1002/(SICI)1098-1004(1999)13:2<99::AID-HUMU2>3.0.CO;2-C
2072:
1434:
1172:
960:
700:
2285:
1377:
1158:
1051:
2268:
Manga P, Kromberg J, Turner A, Jenkins T, Ramsay M (March 2001).
663:
659:
1131:
1127:
1030:
63:
2378:
503:
1056:
In human, the OCA2 gene is located on the long (q) arm of
1595:"A global view of the OCA2-HERC2 region and pigmentation"
319:
1478:. University of Copenhagen. 2008-01-30. Archived from
1037:
involved in small molecule transport, specifically of
1921:
Spritz RA, Fukai K, Holmes SA, Luande J (June 1995).
1114:, a Mexican fish which is characterized by a chronic
484:
921:
896:
870:
845:
1213:
1211:
1209:
1192:
1190:
1188:
1472:"Blue-eyed humans have a single, common ancestor"
266:
165:
1142:caused by mutations in the OCA2 gene is called
1218:GRCm38: Ensembl release 89: ENSMUSG00000030450
2259:: CS1 maint: DOI inactive as of April 2024 (
1045:. Certain mutations in OCA2 result in type 2
542:L-tyrosine transmembrane transporter activity
8:
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519:
307:
206:
103:
2293:
2199:
2156:
2113:
2033:
1938:
1792:
1757:
1714:
1669:
1659:
1618:
1569:
1326:
1076:which are specialized cells that produce
1435:"Here's what made those brown eyes blue"
1268:
1266:
1184:
1150:(light-colored hair and fair skin) and
1009:melanocyte-specific transporter protein
2252:
1454:"One Common Ancestor Behind Blue Eyes"
20:
1404:"Don't it make your brown eyes blue?"
1033:. The P protein is believed to be an
271:
232:
227:
170:
129:
124:
7:
2022:The New England Journal of Medicine
1384:. U.S. National Library of Medicine
1378:"OCA2 - oculocutaneous albinism II"
2274:American Journal of Human Genetics
1927:American Journal of Human Genetics
1869:10.1111/j.1399-0004.1991.tb03076.x
1781:American Journal of Human Genetics
1550:American Journal of Human Genetics
1350:Hayashi M, Suzuki T (April 2013).
1013:pink-eyed dilution protein homolog
918:
893:
867:
842:
818:
799:
773:
750:
724:
705:
489:
431:choroid plexus of fourth ventricle
407:
345:
324:
14:
2325:10.1034/j.1600-0749.2001.140508.x
1759:10.1034/j.1600-0749.2001.140203.x
1019:that in humans is encoded by the
2355:10.1034/j.1600-0749.2002.02007.x
1352:"Oculocutaneous albinism type 2"
609:eye pigment biosynthetic process
493:
255:
248:
242:
219:
154:
147:
141:
116:
1144:oculocutaneous albinism type 2
593:integral component of membrane
563:endoplasmic reticulum membrane
504:More reference expression data
473:More reference expression data
1:
1832:10.1126/science.257.5073.1121
1060:between positions 12 and 13.1
629:cell population proliferation
240:
139:
16:Protein-coding gene in humans
2393:Genes on human chromosome 15
1906:10.1016/0888-7543(95)80220-G
1697:Oetting WS, King RA (1999).
1661:10.1371/journal.pgen.1000867
624:melanin biosynthetic process
439:Epithelium of choroid plexus
365:Epithelium of choroid plexus
2035:10.1056/NEJM199402243300803
1740:Brilliant MH (April 2001).
2419:
1562:10.1016/j.ajhg.2007.11.005
1319:10.1038/s41467-021-21733-z
1082:retinal pigment epithelium
1080:, and in the cells of the
1021:oculocutaneous albinism II
644:melanocyte differentiation
619:developmental pigmentation
427:retinal pigment epithelium
361:retinal pigment epithelium
1611:10.1007/s00439-011-1110-x
1515:10.1007/s00439-007-0460-x
1253:"Mouse PubMed Reference:"
1235:"Human PubMed Reference:"
1099:; and likely involved in
1035:integral membrane protein
991:
986:
982:
975:
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849:
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385:epithelium of nasopharynx
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138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
1959:Human Molecular Genetics
1110:This gene is mutated in
2241:(inactive 2024-04-08).
1452:Bryner J (2008-01-31).
1433:Bryner J (2008-01-31).
1140:Oculocutaneous albinism
1047:oculocutaneous albinism
953:Chr 7: 55.89 – 56.19 Mb
946:Chr 15: 27.75 – 28.1 Mb
634:transmembrane transport
1408:Understanding Genetics
1061:
2343:Pigment Cell Research
2313:Pigment Cell Research
2239:10.1007/s004390051090
1746:Pigment Cell Research
1299:Nature Communications
1152:Prader–Willi syndrome
1122:Clinical significance
1055:
639:spermatid development
132:Chromosome 15 (human)
537:transporter activity
273:7 B5|7 33.44 cM
234:Chromosome 7 (mouse)
2065:1993Natur.361...72R
1824:1992Sci...257.1121G
1818:(5073): 1121–1124.
1311:2021NatCo..12.1447W
588:melanosome membrane
1993:10.1038/ng0694-176
1157:A mutation in the
1112:Astyanax mexicanus
1062:
783:ENSMUSG00000030450
649:tyrosine transport
602:Biological process
568:lysosomal membrane
556:Cellular component
530:Molecular function
447:epithelium of lens
1965:(11): 2047–2051.
1857:Clinical Genetics
1148:Angelman syndrome
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573:endosome membrane
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2073:10.1038/361072a0
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2012:
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1933:(6): 1320–1323.
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1465:
1460:. Imaginova Corp
1449:
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1410:. Archived from
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1194:
1041:—a precursor of
1007:, also known as
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919:
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890:RefSeq (protein)
880:
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413:Top expressed in
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369:secondary oocyte
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351:Top expressed in
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96:OCA2 - orthologs
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2095:
2059:(6407): 72–76.
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2015:
1981:Nature Genetics
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1920:
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1690:Further reading
1687:
1654:(3): e1000867.
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993:View/Edit Mouse
988:View/Edit Human
951:
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941:Location (UCSC)
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764:ENSG00000277361
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760:ENSG00000104044
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107:Gene location (
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2372:External links
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2367:
2349:(3): 217–224.
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2319:(5): 362–367.
2308:
2286:10.1086/318800
2280:(3): 782–787.
2265:
2233:(3): 200–210.
2227:Human Genetics
2222:
2188:Human Mutation
2179:
2151:(2): 166–172.
2145:Human Mutation
2136:
2108:(2): 175–177.
2102:Human Mutation
2093:
2048:
2028:(8): 529–534.
2013:
1987:(2): 176–179.
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1900:(2): 354–363.
1889:
1863:(3): 194–201.
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1807:
1787:(4): 879–884.
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1703:Human Mutation
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1634:
1605:(5): 683–696.
1599:Human Genetics
1585:
1556:(2): 424–431.
1536:
1509:(2): 177–187.
1503:Human Genetics
1492:
1425:
1414:on 12 May 2018
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719:
718:
710:
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697:
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691:
686:
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681:
671:
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641:
636:
631:
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621:
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559:
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531:
527:
526:
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512:
511:
508:
507:
499:
498:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
459:corneal stroma
456:
452:
451:primary oocyte
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
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394:
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381:male germ cell
378:
374:
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
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291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
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177:
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128:
122:
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100:
99:
56:
52:
51:
43:
35:
34:
30:
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26:
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15:
13:
10:
9:
6:
4:
3:
2:
2415:
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2256:
2248:
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2240:
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2228:
2223:
2219:
2215:
2211:
2207:
2202:
2197:
2193:
2189:
2185:
2180:
2176:
2172:
2168:
2164:
2159:
2154:
2150:
2146:
2142:
2137:
2133:
2129:
2125:
2121:
2116:
2111:
2107:
2103:
2099:
2094:
2090:
2086:
2082:
2078:
2074:
2070:
2066:
2062:
2058:
2054:
2049:
2045:
2041:
2036:
2031:
2027:
2023:
2019:
2014:
2010:
2006:
2002:
1998:
1994:
1990:
1986:
1982:
1976:
1972:
1968:
1964:
1960:
1954:
1950:
1946:
1941:
1936:
1932:
1928:
1924:
1919:
1915:
1911:
1907:
1903:
1899:
1895:
1890:
1886:
1882:
1878:
1874:
1870:
1866:
1862:
1858:
1853:
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1755:
1751:
1747:
1743:
1738:
1734:
1730:
1726:
1722:
1717:
1712:
1709:(2): 99–115.
1708:
1704:
1700:
1695:
1694:
1689:
1681:
1677:
1672:
1667:
1662:
1657:
1653:
1649:
1648:PLOS Genetics
1645:
1638:
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1482:on 2013-07-02
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1236:
1230:
1227:
1223:
1219:
1214:
1212:
1210:
1206:
1202:
1198:
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1191:
1189:
1185:
1179:
1177:
1174:
1171:
1166:
1164:
1160:
1155:
1153:
1149:
1145:
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1137:
1133:
1129:
1121:
1119:
1117:
1113:
1108:
1106:
1102:
1098:
1094:
1090:
1085:
1083:
1079:
1075:
1067:
1065:
1059:
1058:chromosome 15
1054:
1050:
1048:
1044:
1040:
1036:
1032:
1028:
1027:
1022:
1018:
1014:
1010:
1006:
994:
989:
985:
981:
978:
974:
967:
965:
962:
958:
954:
950:
947:
943:
939:
932:
930:
924:
920:
917:
911:
909:
905:
899:
895:
892:
888:
881:
879:
873:
869:
866:
860:
858:
854:
848:
844:
841:
839:RefSeq (mRNA)
837:
830:
829:
824:
820:
817:
811:
810:
805:
801:
798:
796:
792:
785:
784:
779:
775:
772:
766:
765:
761:
756:
752:
749:
747:
743:
736:
735:
730:
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723:
717:
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632:
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612:
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584:
581:
579:
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571:
569:
566:
564:
561:
560:
558:
555:
554:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
496:
491:
488:
486:
482:
474:
469:
458:
455:barrel cortex
454:
450:
446:
443:hair follicle
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
380:
376:
373:hair follicle
372:
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
2346:
2342:
2316:
2312:
2277:
2273:
2255:cite journal
2230:
2226:
2191:
2187:
2148:
2144:
2105:
2101:
2056:
2052:
2025:
2021:
1984:
1980:
1962:
1958:
1930:
1926:
1897:
1893:
1860:
1856:
1815:
1811:
1784:
1780:
1752:(2): 86–93.
1749:
1745:
1706:
1702:
1651:
1647:
1637:
1602:
1598:
1588:
1553:
1549:
1539:
1506:
1502:
1495:
1484:. Retrieved
1480:the original
1475:
1462:. Retrieved
1457:
1443:. Retrieved
1438:
1428:
1416:. Retrieved
1412:the original
1407:
1398:
1386:. Retrieved
1381:
1372:
1361:. Retrieved
1355:
1345:
1302:
1298:
1288:
1277:. Retrieved
1256:
1247:
1238:
1229:
1169:
1167:
1156:
1143:
1125:
1109:
1086:
1071:
1063:
1025:
1024:
1020:
1012:
1008:
1004:
1003:
926:
908:NP_001287913
901:
875:
857:NM_001300984
850:
826:
807:
781:
758:
732:
713:
693:
688:
614:pigmentation
435:ciliary body
335:
328:
55:External IDs
18:
1458:LiveScience
1439:Health News
1305:(1): 1447.
1105:iris stroma
1074:melanocytes
393:skin of arm
294:56,186,266
281:55,889,508
193:28,099,315
180:27,754,875
172:15q12-q13.1
33:Identifiers
2387:Categories
2194:(6): 434.
1486:2008-11-06
1464:2008-11-06
1445:2008-11-06
1441:. NBC News
1363:2014-11-09
1279:2015-03-12
1224:, May 2017
1203:, May 2017
1180:References
339:(ortholog)
76:HomoloGene
2398:Eye color
1170:His615Arg
1163:blue eyes
1136:eye color
1005:P protein
929:NP_068679
904:NP_000266
878:NM_021879
853:NM_000275
679:Orthologs
583:cytoplasm
84:GeneCards
2403:Proteins
2363:12028586
2333:11601658
2304:11179026
2247:10987646
2218:34505863
2210:10671067
2167:10649493
2089:21794972
1894:Genomics
1885:28419032
1768:11310796
1733:27315644
1725:10094567
1680:20221248
1629:22065085
1580:18252222
1523:18172690
1418:30 March
1388:30 March
1357:Orphanet
1337:33664263
1220:–
1199:–
1116:Albinism
1068:Function
1039:tyrosine
977:Wikidata
658:Sources:
578:membrane
377:testicle
2295:1274491
2175:1306686
2132:5762140
2124:9259203
2081:8421497
2061:Bibcode
2044:8302318
2009:6185436
2001:7920637
1971:7874125
1949:7762554
1940:1801108
1914:7601462
1877:1773534
1848:5800811
1840:1509264
1820:Bibcode
1812:Science
1803:1415228
1794:1682821
1671:2832666
1620:3325407
1571:2427173
1531:9886658
1328:7933363
1307:Bibcode
1222:Ensembl
1201:Ensembl
1101:melanin
1078:melanin
1043:melanin
1017:protein
1015:, is a
795:UniProt
746:Ensembl
685:Species
664:QuickGO
314:pattern
40:Aliases
2361:
2331:
2302:
2292:
2245:
2216:
2208:
2173:
2165:
2130:
2122:
2087:
2079:
2053:Nature
2042:
2007:
1999:
1969:
1947:
1937:
1912:
1883:
1875:
1846:
1838:
1801:
1791:
1766:
1731:
1723:
1678:
1668:
1627:
1617:
1578:
1568:
1529:
1521:
1335:
1325:
1173:allele
1134:, and
1095:, and
963:search
961:PubMed
828:Q62052
809:Q04671
701:Entrez
485:BioGPS
64:611409
2214:S2CID
2171:S2CID
2128:S2CID
2085:S2CID
2005:S2CID
1881:S2CID
1844:S2CID
1729:S2CID
1527:S2CID
1159:HERC2
734:18431
694:Mouse
689:Human
660:Amigo
397:vulva
389:sperm
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
80:37281
72:97454
2359:PMID
2329:PMID
2300:PMID
2261:link
2243:PMID
2206:PMID
2163:PMID
2120:PMID
2077:PMID
2040:PMID
1997:PMID
1967:PMID
1945:PMID
1910:PMID
1873:PMID
1836:PMID
1799:PMID
1764:PMID
1721:PMID
1676:PMID
1625:PMID
1576:PMID
1519:PMID
1476:News
1420:2013
1390:2013
1333:PMID
1168:The
1132:skin
1128:hair
1097:hair
1093:eyes
1089:skin
1031:gene
1026:OCA2
715:4948
423:iris
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
88:OCA2
60:OMIM
47:OCA2
24:OCA2
2351:doi
2321:doi
2290:PMC
2282:doi
2235:doi
2231:105
2196:doi
2153:doi
2110:doi
2069:doi
2057:361
2030:doi
2026:330
1989:doi
1935:PMC
1902:doi
1865:doi
1828:doi
1816:257
1789:PMC
1754:doi
1711:doi
1666:PMC
1656:doi
1615:PMC
1607:doi
1603:131
1566:PMC
1558:doi
1511:doi
1507:123
1323:PMC
1315:doi
1011:or
290:End
189:End
92:OMA
68:MGI
2389::
2357:.
2347:15
2345:.
2327:.
2317:14
2315:.
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2288:.
2278:68
2276:.
2272:.
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2253:{{
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2212:.
2204:.
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2190:.
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2161:.
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2147:.
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2118:.
2106:10
2104:.
2100:.
2083:.
2075:.
2067:.
2055:.
2038:.
2024:.
2020:.
2003:.
1995:.
1983:.
1961:.
1943:.
1931:56
1929:.
1925:.
1908:.
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1871:.
1861:40
1859:.
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1834:.
1826:.
1814:.
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1762:.
1750:14
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1719:.
1707:13
1705:.
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1331:.
1321:.
1313:.
1303:12
1301:.
1297:.
1265:^
1255:.
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1187:^
1138:.
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1091:,
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662:/
296:bp
283:bp
195:bp
182:bp
90:;
86::
82:;
78::
74:;
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66:;
62::
2365:.
2353::
2335:.
2323::
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2237::
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2198::
2177:.
2155::
2134:.
2112::
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2071::
2063::
2046:.
2032::
2011:.
1991::
1985:7
1973:.
1963:3
1951:.
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1422:.
1392:.
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1339:.
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1282:.
1259:.
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1023:(
214:)
111:)
94::
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