298:, made by Jacobs and hence considered the first little research on it. However, the experimental design had many flaws, including small sample sizes, biased sampling, and poor definition of the phenotype "aggression", resulted in the mischaracterization of XYY individuals as aggressive and violent criminals, which led the path for many biased studies on height-selected, institutionalised XYY individuals in the following decades.
306:
Jacobs has received many awards in recognition of her work, including the 1999 Mauro
Baschirotto Award of the European Society of Human Genetics and the 2011 March of Dimes Prize in Developmental Biology. Her services to genetics saw her named an OBE in 1999. Jacobs was elected as a Foreign Associate
1145:
The addition of a Y chromosome to a normal male chromosome constitution does not produce a discernible phenotype. Males with 47,XYY cannot be characterised by discriminating physical or behavioural features. The first diagnosis of this condition, therefore, was a karyotypic and not a phenotypic
470:
1652:
1622:
326:. She was the first recipient of the KS&A Patricia Jacobs Lifetime Achievement Award from the US charity Knowledge Support & Action. In February 2010, Jacobs was elected as a member of the
1223:
1617:
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Jacobs, Patricia A.; Brunton, Muriel; Melville, Marie M.; Brittain, Robert P.; McClemont, William F. (25 December 1965). "Aggressive behavior, mental sub-normality and the XYY male".
1627:
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419:"The William Allan Memorial Award. Presented to Patricia A. Jacobs, D.Sc., at the annual meeting of the American Society of Human Genetics, Dallas, October 28–31, 1981"
1662:
1632:
1607:
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327:
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Price, William H.; Strong, John A.; Whatmore, Peter B.; McClemont, William F. (12 March 1966). "Criminal patients with XYY sex-chromosome complement".
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371:"Jacobs, Prof. Patricia Ann, (born 8 Oct. 1934), Co-Director of Research, Wessex Regional Genetics Laboratory, 2001–15 (Director, 1988–2001)"
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Milunsky, Jeff M. (2010). "Prenatal diagnosis of sex chromosome abnormalities". In
Milunsky, Aubrey; Milunsky, Jeff M. (eds.).
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1602:
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JACOBS PA, STRONG JA (31 January 1959). "A case of human intersexuality having a possible XXY sex-determining mechanism".
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Sandberg, Avery A.; Koepf, George F.; Ishihara, Takaaki; Hauschka, Theodore S. (26 August 1961). "An XYY human male".
323:
238:
and is
Honorary Professor of Human Genetics, Co-director of Research, Wessex Regional Genetics Laboratory, within the
225:
219:
45:
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Jacobs, Patricia A.; Price, William H.; Court Brown, W. Michael; Brittain, Robert P.; Whatmore, Peter B. (May 1968).
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Hauschka, Theodore S.; Hasson, John E.; Goldstein, Milton N.; Koepf, George F.; Sandberg, Avery A. (March 1962).
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987:"The William Allan Memorial Award address: human population cytogenetics: the first twenty-five years"
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827:"Behaviour disorders and pattern of crime among XYY males identified at a maximum security hospital"
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193:
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LEJEUNE J, GAUTHIER M, TURPIN R (26 January 1959). "Human chromosomes in tissue cultures".
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described an additional X chromosome in male patients (the 47,XXY karyotype) also known as
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1489:
1484:
1479:
1459:
1383:
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1130:
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is instead sometimes called Jacobs syndrome: After it had been incidentally discovered by
250:
Jacobs was born on 8 October 1934 to Sadie (née Jones) and Cyril Jacobs. She attended the
294:
in 1961, the syndrome was also found in a chromosome survey of 315 men at a hospital for
1183:
791:
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had already diagnosed the symptoms in 1942. Despite her work being on XXY syndrome, the
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Court Brown, W. Michael; Price, William H.; Jacobs, Patricia A. (23 November 1968).
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Court Brown, W. Michael; Price, William H.; Jacobs, Patricia A. (11 May 1968).
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589:
1180:"Knowledge Support & Action – Patricia Jacobs Lifetime Achievement Award"
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436:
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First years of human chromosomes : the beginnings of human cytogenetics
889:
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330:, the induction ceremony took place in April. In 2011, Jacobs received the
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620:"An XYY man with progeny indicating familial tendency to non-disjunction"
1051:"Media sensationalism and science: The case of the criminal chromosome"
231:
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51:
48:
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800:
773:
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254:, graduating in 1956 with a BSc with first class honours in zoology.
173:
1127:
Genetic disorders and the fetus: diagnosis, prevention and treatment
471:
Comptes Rendus
Hebdomadaires des Séances de l'Académie des Sciences
1224:"Salisbury District Hospital Geneticist Wins International Honour"
1148:
Pubertal development is normal and these men are usually fertile.
577:
on
Genetics Home Reference, Other Names. Retrieved 6 August 2017
42:
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956:
831:
39:
917:"Chromosome studies on men in a maximum security hospital"
772:
Price, William H.; Whatmore, Peter B. (25 February 1967).
1055:
Expository science: Forms and functions of popularisation
1094:
Making genes, making waves: A social activist in science
1653:
Fellows of the Royal
College of Physicians of Edinburgh
1623:
Foreign associates of the
National Academy of Sciences
825:
Price, William H.; Whatmore, Peter B. (4 March 1967).
872:"Further information on the identity of 47,XYY males"
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KS&A Patricia Jacobs
Lifetime Achievement Award
128:
118:
96:
86:
76:
58:
34:
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346:. She has two step-daughters and three step-sons.
1022:Harper, Peter S. (2006). "The sex chromosomes".
1618:Fellows of the American Statistical Association
741:editorial (12 March 1966). "The YY syndrome".
1282:
498:"The Office of Women in Science and Medicine"
8:
1261:History of Modern Biomedicine Research Group
1053:. In Shinn, Terry; Whitley, Richard (eds.).
377:, Oxford University Press, 1 December 2007,
1628:Officers of the Order of the British Empire
1638:Academics of the University of Southampton
1289:
1275:
1267:
328:United States National Academy of Sciences
31:
1673:Wellcome Trust Principal Research Fellows
1643:Fellows of the Royal Society of Edinburgh
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897:
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799:
637:
444:
1658:Academics of the University of Edinburgh
355:
1663:21st-century Scottish women scientists
1633:Alumni of the University of St Andrews
985:Jacobs, Patricia A. (September 1982).
1089:"The myth of the criminal chromosome"
270:in Down syndrome, basing himself off
7:
774:"Criminal behavior and the XYY male"
412:
410:
408:
365:
363:
361:
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234:(born 8 October 1934) is a Scottish
1608:Female fellows of the Royal Society
383:10.1093/ww/9780199540884.013.u21706
1026:. Bloxham: Scion. pp. 77–96.
992:American Journal of Human Genetics
935:10.1111/j.1469-1809.1968.tb00566.x
625:American Journal of Human Genetics
424:American Journal of Human Genetics
320:American Society of Human Genetics
25:
1668:21st-century Scottish scientists
417:Hamerton, J L (September 1982).
334:Prize in Developmental Biology.
309:US National Academy of Sciences
137:in Developmental Biology (2011)
1086:Beckwith, Jonathan R. (2002).
132:Mauro Baschirotto Award (1999)
1:
757:10.1016/S0140-6736(66)90771-9
726:10.1016/S0140-6736(66)90760-4
603:10.1016/S0140-6736(61)92459-X
322:. In 1993, she was elected a
1613:Fellows of the Royal Society
1096:. Cambridge, Massachusetts:
316:William Allan Memorial Award
140:William Allan Memorial Award
324:Fellow of the Royal Society
179:Cytogenetic studies (1966)
1694:
1198:"Top honour for scientist"
314:In 1981, she received the
1162:. Retrieved 21 July 2008
1160:The Royal Society website
262:In 1959, five days after
240:University of Southampton
184:
162:University of Southampton
147:
1678:Scottish women academics
1129:(6th ed.). Oxford:
1098:Harvard University Press
970:10.1136/bmj.4.5629.513-a
922:Annals of Human Genetics
296:developmentally disabled
252:University of St Andrews
246:Early life and education
91:University of St Andrews
890:10.1136/bmj.2.354.325-a
877:British Medical Journal
502:www.hopkinsmedicine.org
113:Philadelphia Chromosome
1519:Bruce William Stillman
1057:. Dordrecht, Holland:
1049:Green, Jeremy (1985).
845:10.1136/bmj.1.5539.533
1572:Edwin Ernest Salpeter
1508:Brian Geoffrey Spratt
1603:Scottish geneticists
1525:Andrew James Thomson
1438:Michael Joseph Kelly
1133:. pp. 273–312.
342:In 1972 she married
280:Klinefelter syndrome
274:'s work, Jacobs and
135:March of Dimes Prize
101:Klinefelter syndrome
1405:Michael George Hall
1394:Christopher Garrett
1166:9 June 2008 at the
792:1967Natur.213..815P
679:1965Natur.208.1351J
538:1959Natur.183..302J
258:Career and research
217:Patricia Ann Jacobs
36:Patricia Ann Jacobs
18:Patricia Ann Jacobs
1514:David J. Stevenson
1363:Geoffrey Dearnaley
1234:on 14 October 2017
1204:. 16 February 2010
1061:Pub. Co. pp.
302:Awards and honours
27:British geneticist
1648:Human geneticists
1580:
1579:
1465:Michael Neuberger
1433:Franz Daniel Kahn
1411:Roger Heath-Brown
1345:Tim Clutton-Brock
1202:Salisbury Journal
1140:978-1-4051-9087-9
1111:978-0-674-00928-8
1072:978-90-277-1831-0
1033:978-1-904842-24-8
687:10.1038/2081351a0
597:(7200): 488–489.
392:978-0-19-954088-4
284:Harry Klinefelter
214:
213:
149:Scientific career
16:(Redirected from
1685:
1369:Richard R. Ernst
1351:Richard Crowther
1340:Lennart Carleson
1330:Michael Burdekin
1291:
1284:
1277:
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1230:. Archived from
1228:salisbury.nhs.uk
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1490:Edward Reynolds
1485:Ghillean Prance
1480:Colin Pillinger
1475:Colin Patterson
1460:Angus Macintyre
1428:Patricia Jacobs
1384:Edward Fraenkel
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884:(5601): 325–8.
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839:(5539): 533–6.
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771:
751:(7437): 583–4.
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720:(7437): 565–6.
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575:47,XYY syndrome
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532:(4657): 302–3.
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1567:Motoo Kimura
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1455:Sydney Leach
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1422:Robin Irvine
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1399:Keith Glover
1374:Martin Evans
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1320:Alan Astbury
1236:. Retrieved
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288:XYY syndrome
261:
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155:Institutions
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105:XYY syndrome
29:
1593:1934 births
1536:A.E. Walsby
1496:John Rhodes
1449:Trevor Lamb
1416:John Hughes
1379:Ian Fleming
1100:. pp.
276:John Strong
194:southampton
77:Nationality
1587:Categories
1541:John White
1470:Ian Newton
1146:discovery.
744:The Lancet
713:The Lancet
590:The Lancet
507:15 January
350:References
268:trisomy-21
236:geneticist
65:1934-10-08
1502:Jim Smith
1059:D. Reidel
437:0002-9297
375:Who's Who
318:from the
311:in 2010.
200:/medicine
109:Trisomy X
87:Education
1304:elected
1164:Archived
978:62593088
943:83969793
648:13905424
611:13746118
562:38349997
554:13632697
484:13629913
398:5 August
1550:Foreign
1313:Fellows
1306:in 1993
1300:of the
1298:Fellows
1263:website
1259:on the
1238:13 June
1208:13 June
1102:116–134
1063:139–161
1015:6751075
1006:1685430
908:5689727
899:1985597
863:6017153
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818:4158233
810:6031815
788:Bibcode
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734:4159988
703:4145850
695:5870205
675:Bibcode
639:1932182
534:Bibcode
455:6751074
446:1685433
307:of the
232:FRCPath
229:FMedSci
206:/pj2f09
189:Website
81:British
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202:/about
174:Thesis
129:Awards
119:Spouse
974:S2CID
939:S2CID
814:S2CID
699:S2CID
558:S2CID
282:, as
208:.page
1240:2017
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1135:ISBN
1106:ISBN
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1011:PMID
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550:PMID
509:2024
480:PMID
451:PMID
433:ISSN
400:2018
387:ISBN
223:FRSE
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1001:PMC
966:doi
957:BMJ
931:doi
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886:doi
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796:doi
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