33:
1103:
618:
Elitt, Matthew S.; Barbar, Lilianne; Shick, H. Elizabeth; Powers, Berit E.; Maeno-Hikichi, Yuka; Madhavan, Mayur; Allan, Kevin C.; Nawash, Baraa S.; Gevorgyan, Artur S.; Hung, Stevephen; Nevin, Zachary S.; Olsen, Hannah E.; Hitomi, Midori; Schlatzer, Daniela M.; Zhao, Hien T.; Swayze, Adam; LePage,
998:
Their research was published online July 1 in the journal Nature. "The pre-clinical results were profound. PMD mouse models that typically die within a few weeks of birth were able to live a full lifespan after treatment," said Paul
939:
Elitt, Matthew S.; Barbar, Lilianne; Shick, H. Elizabeth; Powers, Berit E.; Maeno-Hikichi, Yuka; Madhavan, Mayur; Allan, Kevin C.; Nawash, Baraa S.; Nevin, Zachary S.; Olsen, Hannah E.; Hitomi, Midori (December 31, 2018).
1011:
Elitt, Matthew S.; Barbar, Lilianne; Shick, H. Elizabeth; Powers, Berit E.; Maeno-Hikichi, Yuka; Madhavan, Mayur; Allan, Kevin C.; Nawash, Baraa S.; Gevorgyan, Artur S.; Hung, Stevephen; Nevin, Zachary S. (July 1, 2020).
1179:
552:
Najm, Fadi J.; Madhavan, Mayur; Zaremba, Anita; Shick, Elizabeth; Karl, Robert T.; Factor, Daniel C.; Miller, Tyler E.; Nevin, Zachary S.; Kantor, Christopher; Sargent, Alex; Quick, Kevin L. (June 2015).
754:
420:
1104:"The ISSCR Announces 2015 Recipients of the McEwen Award for Innovation, the ISSCR-BD Biosciences Outstanding Young Investigator, and the ISSCR Public Service Awards, 20 January, 2015"
501:
Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, et al. (July 2007). "New cell lines from mouse epiblast share defining features with human embryonic stem cells".
298:
239:
181:
1081:
476:
1169:
802:
896:"New method adds missing functionality to brain organoids: Protocol adds a new cell type enabling myelination in human 'mini-brains' for laboratory research"
377:
1184:
359:
283:
746:
694:
413:
291:
1154:
263:
903:
776:
925:
824:
346:
318:
1077:
472:
333:, called oligocortical spheroids. Tesar identified drugs that stimulate myelin regeneration and reverse paralysis in mice with
259:
64:
959:
1159:
199:
720:
1126:
458:
386:
676:
104:
798:
275:
93:
342:
287:
120:
32:
981:
1164:
322:
279:
243:
235:
159:
1174:
1025:
698:
632:
566:
510:
75:
367:
769:"More efficiently generating brain stem cells: Technique improves understanding of myelin disease"
917:
895:
816:
768:
534:
334:
302:
1059:
1041:
877:
859:
658:
600:
582:
526:
942:"Therapeutic suppression of proteolipid protein rescues Pelizaeus-Merzbacher Disease in mice"
918:"Drugs stimulate body's own stem cells to replace the brain cells lost in multiple sclerosis"
1049:
1033:
949:
867:
851:
648:
640:
590:
574:
518:
191:
126:
555:"Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo"
314:
255:
44:
619:
David F.; Jiang, Weihong; Conlon, Ronald A.; Rigo, Frank; Tesar, Paul J. (July 1, 2020).
1029:
636:
570:
514:
1054:
1013:
872:
839:
653:
620:
595:
554:
238:. He is the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics at
1148:
1121:
747:"School of Medicine faculty member receives prestigious award for stem cell research"
98:
941:
538:
724:
450:
1037:
855:
644:
345:
therapeutics that restored myelination and extended the lifespan of mice with
1045:
863:
586:
301:
to teach. In 2014 he was appointed to the Dr. Donald and Ruth Weber
Goodman
153:
1063:
881:
662:
604:
530:
838:
Madhavan M, Nevin ZS, Shick HE, Garrison E, et al. (September 2018).
1014:"Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease"
621:"Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease"
326:
578:
522:
982:"Research finds new approach to treating certain neurological diseases"
840:"Induction of myelinating oligodendrocytes in human cortical spheroids"
338:
330:
1078:"NYSCF - Robertson Investigator Wins International Stem Cell Award"
954:
473:"Paul Tesar Named 2017 NYSCF - Robertson Stem Cell Prize Recipient"
695:"Tesar '03 Continues to Excel – International Biomedical Alliance"
282:, research for which he received both the Beddington Medal of the
164:
264:
National
Institutes of Health Oxford-Cambridge Scholar Program
71:
60:
274:
While a graduate student, Tesar published a paper describing
1180:
Case
Western Reserve University School of Medicine alumni
817:"Ordinary skin cells morphed into functional brain cells"
799:"Study: New process converts skin cells into brain cells"
220:
215:
190:
174:
146:
113:
85:
52:
39:
23:
299:Case Western Reserve University School of Medicine
240:Case Western Reserve University School of Medicine
496:
494:
721:"Paul Tesar – International Biomedical Alliance"
455:BSDB - British Society for Developmental Biology
414:"Harold M. Weintraub Awardees from 2001-2014"
313:Tesar developed methods to generate and grow
8:
378:International Society for Stem Cell Research
408:
406:
258:. He graduated with a BSc in biology from
31:
20:
1053:
953:
871:
652:
594:
360:British Society for Developmental Biology
325:and skin cells. He also made human brain
284:British Society for Developmental Biology
1170:Case Western Reserve University faculty
827:from the original on September 6, 2015.
402:
182:Case Western Reserve School of Medicine
928:from the original on January 12, 2016.
906:from the original on November 1, 2019.
805:from the original on November 1, 2019.
757:from the original on December 4, 2019.
376:Outstanding Young Investigator Award,
292:Fred Hutchinson Cancer Research Center
1084:from the original on November 1, 2019
962:from the original on October 26, 2019
779:from the original on November 1, 2019
479:from the original on November 1, 2019
461:from the original on January 3, 2014.
426:from the original on November 1, 2019
7:
445:
443:
441:
1185:Alumni of the University of Oxford
14:
319:oligodendrocyte progenitor cells
16:American developmental biologist
260:Case Western Reserve University
132:Robertson Stem Cell Prize, 2017
65:Case Western Reserve University
1:
1127:National Academy of Inventors
387:National Academy of Inventors
242:. His research is focused on
1155:American medical researchers
801:. CBS News. April 15, 2013.
347:Pelizaeus–Merzbacher disease
305:in innovative therapeutics.
105:Pelizaeus-Merzbacher disease
276:epiblast-derived stem cells
266:, he earned a PhD in 2007.
1201:
358:Beddington Medal from the
1038:10.1038/s41586-020-2494-3
856:10.1038/s41592-018-0081-4
645:10.1038/s41586-020-2494-3
343:antisense oligonucleotide
288:Harold M. Weintraub Award
211:
139:
121:Harold M. Weintraub Award
30:
337:. Tesar also identified
262:in 2003. As part of the
250:Early life and education
297:In 2010 he returned to
236:developmental biologist
451:"The Beddington Medal"
323:pluripotent stem cells
1160:Stem cell researchers
1122:"Senior Members List"
683:. September 17, 2004.
385:Senior Member of the
280:pluripotent stem cell
244:regenerative medicine
160:developmental biology
753:. February 5, 2015.
1030:2020Natur.585..397E
637:2020Natur.585..397E
579:10.1038/nature14335
571:2015Natur.522..216N
523:10.1038/nature05972
515:2007Natur.448..196T
368:Harold M. Weintraub
99:myelin regeneration
94:epiblast stem cells
335:multiple sclerosis
254:Tesar was born in
1024:(7825): 397–403.
631:(7825): 397–403.
565:(7555): 216–220.
329:containing human
229:
228:
192:Doctoral advisors
141:Scientific career
1192:
1139:
1138:
1136:
1134:
1118:
1112:
1111:
1100:
1094:
1093:
1091:
1089:
1074:
1068:
1067:
1057:
1008:
1002:
1001:
995:
993:
978:
972:
971:
969:
967:
957:
936:
930:
929:
914:
908:
907:
892:
886:
885:
875:
835:
829:
828:
813:
807:
806:
795:
789:
788:
786:
784:
765:
759:
758:
743:
737:
736:
734:
732:
723:. Archived from
717:
711:
710:
708:
706:
697:. Archived from
691:
685:
684:
673:
667:
666:
656:
615:
609:
608:
598:
549:
543:
542:
498:
489:
488:
486:
484:
469:
463:
462:
447:
436:
435:
433:
431:
425:
418:
410:
382:
373:
364:
315:oligodendrocytes
278:, a new type of
225:
222:
127:Beddington Medal
68:
35:
21:
1200:
1199:
1195:
1194:
1193:
1191:
1190:
1189:
1145:
1144:
1143:
1142:
1132:
1130:
1120:
1119:
1115:
1102:
1101:
1097:
1087:
1085:
1076:
1075:
1071:
1010:
1009:
1005:
991:
989:
980:
979:
975:
965:
963:
938:
937:
933:
916:
915:
911:
894:
893:
889:
837:
836:
832:
815:
814:
810:
797:
796:
792:
782:
780:
767:
766:
762:
745:
744:
740:
730:
728:
727:on May 22, 2022
719:
718:
714:
704:
702:
701:on May 22, 2022
693:
692:
688:
677:"The BriefCase"
675:
674:
670:
617:
616:
612:
551:
550:
546:
509:(7150): 196–9.
500:
499:
492:
482:
480:
471:
470:
466:
449:
448:
439:
429:
427:
423:
416:
412:
411:
404:
399:
393:
380:
371:
362:
355:
311:
272:
256:Cleveland, Ohio
252:
234:is an American
219:
207:
200:Richard Gardner
186:
170:
135:
109:
103:treatments for
81:
59:
48:
45:Cleveland, Ohio
26:
17:
12:
11:
5:
1198:
1196:
1188:
1187:
1182:
1177:
1172:
1167:
1162:
1157:
1147:
1146:
1141:
1140:
1113:
1095:
1069:
1003:
988:. July 1, 2020
973:
955:10.1101/508192
931:
909:
887:
844:Nature Methods
830:
808:
790:
760:
738:
712:
686:
668:
610:
544:
490:
464:
437:
401:
400:
398:
395:
391:
390:
383:
374:
365:
354:
351:
310:
307:
271:
268:
251:
248:
227:
226:
217:
213:
212:
209:
208:
206:
205:
202:
196:
194:
188:
187:
185:
184:
178:
176:
172:
171:
169:
168:
162:
157:
150:
148:
144:
143:
137:
136:
134:
133:
130:
124:
117:
115:
111:
110:
108:
107:
101:
96:
89:
87:
86:Known for
83:
82:
80:
79:
69:
56:
54:
50:
49:
43:
41:
37:
36:
28:
27:
24:
15:
13:
10:
9:
6:
4:
3:
2:
1197:
1186:
1183:
1181:
1178:
1176:
1173:
1171:
1168:
1166:
1165:Living people
1163:
1161:
1158:
1156:
1153:
1152:
1150:
1129:
1128:
1123:
1117:
1114:
1109:
1105:
1099:
1096:
1083:
1079:
1073:
1070:
1065:
1061:
1056:
1051:
1047:
1043:
1039:
1035:
1031:
1027:
1023:
1019:
1015:
1007:
1004:
1000:
987:
986:MedicalXpress
983:
977:
974:
961:
956:
951:
947:
943:
935:
932:
927:
923:
919:
913:
910:
905:
901:
897:
891:
888:
883:
879:
874:
869:
865:
861:
857:
853:
850:(9): 700–06.
849:
845:
841:
834:
831:
826:
822:
818:
812:
809:
804:
800:
794:
791:
778:
774:
770:
764:
761:
756:
752:
748:
742:
739:
726:
722:
716:
713:
700:
696:
690:
687:
682:
678:
672:
669:
664:
660:
655:
650:
646:
642:
638:
634:
630:
626:
622:
614:
611:
606:
602:
597:
592:
588:
584:
580:
576:
572:
568:
564:
560:
556:
548:
545:
540:
536:
532:
528:
524:
520:
516:
512:
508:
504:
497:
495:
491:
478:
474:
468:
465:
460:
456:
452:
446:
444:
442:
438:
422:
415:
409:
407:
403:
396:
394:
388:
384:
379:
375:
369:
366:
361:
357:
356:
352:
350:
348:
344:
340:
336:
332:
328:
324:
320:
316:
308:
306:
304:
300:
295:
293:
289:
285:
281:
277:
269:
267:
265:
261:
257:
249:
247:
245:
241:
237:
233:
232:Paul J. Tesar
224:
218:
214:
210:
203:
201:
198:
197:
195:
193:
189:
183:
180:
179:
177:
173:
166:
163:
161:
158:
155:
152:
151:
149:
145:
142:
138:
131:
128:
125:
122:
119:
118:
116:
112:
106:
102:
100:
97:
95:
92:discovery of
91:
90:
88:
84:
77:
73:
70:
66:
62:
58:
57:
55:
51:
46:
42:
38:
34:
29:
25:Paul J. Tesar
22:
19:
1131:. Retrieved
1125:
1116:
1107:
1098:
1086:. Retrieved
1072:
1021:
1017:
1006:
997:
990:. Retrieved
985:
976:
966:November 23,
964:. Retrieved
945:
934:
922:ScienceDaily
921:
912:
900:ScienceDaily
899:
890:
847:
843:
833:
821:ScienceDaily
820:
811:
793:
781:. Retrieved
773:ScienceDaily
772:
763:
750:
741:
731:November 20,
729:. Retrieved
725:the original
715:
703:. Retrieved
699:the original
689:
681:The Observer
680:
671:
628:
624:
613:
562:
558:
547:
506:
502:
481:. Retrieved
467:
454:
428:. Retrieved
392:
321:(OPCs) from
312:
296:
273:
253:
231:
230:
204:Ronald McKay
175:Institutions
140:
18:
1175:1981 births
1088:November 1,
783:November 1,
705:January 18,
483:November 1,
430:November 1,
1149:Categories
948:: 508192.
397:References
1108:isscr.org
1046:1476-4687
864:1548-7105
751:The Daily
587:1476-4687
327:organoids
154:stem cell
53:Education
1133:June 24,
1082:Archived
1064:32610343
960:Archived
926:Archived
904:Archived
882:30046099
825:Archived
803:Archived
777:Archived
755:Archived
663:32610343
605:25896324
531:17597760
477:Archived
459:Archived
421:Archived
309:Research
286:and the
221:tesarlab
1055:7810164
1026:Bibcode
992:July 1,
946:bioRxiv
873:6508550
654:7810164
633:Bibcode
596:4528969
567:Bibcode
539:4430584
511:Bibcode
290:of the
216:Website
167:biology
156:biology
1062:
1052:
1044:
1018:Nature
880:
870:
862:
661:
651:
625:Nature
603:
593:
585:
559:Nature
537:
529:
503:Nature
381:(2015)
372:(2008)
370:Award
363:(2008)
353:Awards
339:CRISPR
331:myelin
270:Career
147:Fields
129:, 2008
123:, 2008
114:Awards
78:, 2007
76:Oxford
67:, 2003
999:Tesar
535:S2CID
424:(PDF)
417:(PDF)
303:chair
165:glial
1135:2022
1090:2019
1060:PMID
1042:ISSN
994:2020
968:2019
878:PMID
860:ISSN
785:2019
733:2019
707:2020
659:PMID
601:PMID
583:ISSN
527:PMID
485:2019
432:2019
341:and
317:and
223:.com
47:, US
40:Born
1050:PMC
1034:doi
1022:585
950:doi
868:PMC
852:doi
649:PMC
641:doi
629:585
591:PMC
575:doi
563:522
519:doi
507:448
349:.
294:.
72:PhD
61:BSc
1151::
1124:.
1106:.
1080:.
1058:.
1048:.
1040:.
1032:.
1020:.
1016:.
996:.
984:.
958:.
944:.
924:.
920:.
902:.
898:.
876:.
866:.
858:.
848:15
846:.
842:.
823:.
819:.
775:.
771:.
749:.
679:.
657:.
647:.
639:.
627:.
623:.
599:.
589:.
581:.
573:.
561:.
557:.
533:.
525:.
517:.
505:.
493:^
475:.
457:.
453:.
440:^
419:.
405:^
246:.
74:,
63:,
1137:.
1110:.
1092:.
1066:.
1036::
1028::
970:.
952::
884:.
854::
787:.
735:.
709:.
665:.
643::
635::
607:.
577::
569::
541:.
521::
513::
487:.
434:.
389:,
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
