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hypoxia and molecular targeted therapies. Workman also continued his service for the
European Organisation for Research and Treatment of Cancer (EORTC) as Chairman of the EORTC Pharmacology and Molecular Mechanisms Group. Member of EORTC Board and Council as Chairman of the EORTC New Drug Development Coordinating Committee.
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In 1991 Workman was appointed as a Cancer
Research Campaign (CRC) Life Fellow, Professor of Experimental Cancer Therapy, University of Glasgow and Director of Laboratory Research in the CRC Department of Medical Oncology, CRC Beatson Laboratories, Glasgow. Here he extended his research on tumour
348:
Cancer
Therapeutics Unit. Overall, since 2005, the Cancer Therapeutic Unit has discovered 17 drug candidates, seven of which have progressed to the patient trial stage. Workman has attributed this record to "taking early academic risks, combining academic and pharmaceutical expertise, and
349:
implementing strong leadership and project management. Other contributing factors include running multiple projects on a competitive scale, establishing long-term financial support and – most important – selecting productive and timely industrial collaborations."
539:"Identification of Novel Small Molecule Inhibitors of Hypoxia-Inducible Factor-1 That Differentially Block Hypoxia-Inducible Factor-1 Activity and Hypoxia-Inducible Factor-1α Induction in Response to Hypoxic Stress and Growth Factors"
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Chau, Noan-Minh; Rogers, Paul; Aherne, Wynne; Carroll, Veronica; Collins, Ian; McDonald, Edward; Workman, Paul; Ashcroft, Margaret (1 June 2005).
755:"Professor Paul Workman has been appointed as Chief Executive and President of The Institute of Cancer Research, London, on a permanent basis"
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246:(born 30 March 1952) is a British scientist noted for his work on the discovery and development of pharmaceutical agents in the field of
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SABCS 2010: Molecular chaperones: cancer dependence and druggability – Prof Paul
Workman – The Institute of Cancer Research, Sutton, UK
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The early part of his career (1976–90) was spent establishing and leading the
Pharmacology and New Drug Development Laboratory at the
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and SRI International, California, USA where he continued his work on tumour hypoxia funded by a
Fellowship from what was then the
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856:"NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis"
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367:. The leading Hsp90 inhibitor was discovered by Workman's team at ICR in collaboration with Vernalis.
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Workman is currently working on drugs that block molecules essential for the growth and survival of
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282:, England. He was educated at Workington County Grammar School, Cumbria, and completed his
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896:"Cancer Drug Researcher Receives Royal Society of Chemistry Award – ICR Global Foundation"
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In 1990 Workman spent a sabbatical period in the
Department of Therapeutic Radiology,
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Workman, Paul (2004). "Pharmacological
Intervention With Multistep Oncogenesis".
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2014 awarded
Raymond Bourgine Award for "exceptional contributions to oncology".
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in March 2011. He was later elected as
President and CEO in November 2014.
918:"George and Christine Sosnovsky Award in Cancer Therapy Previous Winners"
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Workman, Paul. "Emerging Molecular Therapies: Small-Molecule Drugs".
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Powers, Marissa V.; Workman, Paul (2015). "Molecular Chaperones".
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New Approaches in Cancer Pharmacology: Drug Design and Development
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706:"Academia and industry: Successes for UK cancer partnership"
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Fellows of the Academy of Medical Sciences (United Kingdom)
388:
George and Christine Sosnovsky Award in Cancer Therapy
685:. 5 (suppl 5). Kluwer Academic Publishers: 7–16. 1994
943:"Oncology: Pierre Fabre sponsors the Bourgine Prize"
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Eccles, SA; Massey, A; Raynaud, FI (15 April 2008).
772:. Springer, Berlin, Heidelberg. pp. 2894–2898.
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Studies on some enzyme-activated anti-tumour agents
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306:degree from the University of Leicester in 2009.
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801:Workman, Paul (30 September 2003). "Preface ".
590:. Humana Press, Totowa, NJ. pp. 325–337.
418:. Springer, Berlin, Heidelberg. pp. 1–4.
395:2016 elected Fellow of the Royal Society (FRS)
363:, in particular, molecular chaperones such as
1391:Academics of the Institute of Cancer Research
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1396:Academics of the University of Cambridge
454:. Oxford University Press. November 2015
379:Fellow of the Royal Society of Chemistry
352:Workman was appointed Deputy CEO of the
406:
414:Workman, Paul (1994). "Introduction".
1371:Alumni of the University of Leicester
298:degree in Cancer Pharmacology at the
274:Workman was born on 30 March 1952 in
7:
676:"History of NCI-EORTC collaboration"
753:Workman, Paul (24 November 2014).
331:International Union Against Cancer
14:
1376:Alumni of the University of Leeds
318:'s Clinical Oncology Unit at the
621:Principles of Molecular Oncology
256:The Institute of Cancer Research
643:"Cancer Research announcements"
501:"Paul Workman moves to Glasgow"
922:The Royal Society of Chemistry
778:10.1007/978-3-662-46875-3_3810
704:Workman, Paul (11 June 2014).
16:British oncologist (born 1952)
1:
873:10.1158/0008-5472.CAN-07-5256
556:10.1158/0008-5472.CAN-04-4453
1406:Fellows of the Royal Society
596:10.1007/978-1-59259-767-3_22
174:Institute of Cancer Research
945:. Pierre Fabre. 2 June 2014
804:Current Cancer Drug Targets
424:10.1007/978-3-642-79088-1_1
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1193:Lakshminarayanan Mahadevan
386:Royal Society of Chemistry
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154:
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898:. Icrgf.org. 4 June 2010
817:10.2174/1568009033481840
479:"Professor Paul Workman"
316:Medical Research Council
302:. He later received an
262:Education and early life
508:Annals of Oncology News
344:in 1997 to develop its
320:University of Cambridge
292:University of Leicester
222:/professor-paul-workman
169:University of Cambridge
102:University of Leicester
1366:People from Workington
770:Encyclopedia of Cancer
588:Cancer Chemoprevention
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220:/researchers-and-teams
448:"WORKMAN, Prof. Paul"
269:
623:. pp. 421–438.
722:2014Natur.510..218W
340:Workman joined the
327:Stanford University
310:Career and research
300:University of Leeds
108:University of Leeds
1386:English scientists
1381:English biologists
1213:Simon Peyton Jones
683:Annals of Oncology
516:Annals of Oncology
371:Awards and honours
346:Cancer Research UK
272:
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1168:Eugenia Kumacheva
1063:Alastair Compston
1048:Katharine Cashman
787:978-3-662-46874-6
656:: 3297–3298. 1988
549:(11): 4918–4928.
433:978-3-642-79090-4
252:President and CEO
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156:Scientific career
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1228:Sriram Ramaswamy
1173:Corinne Le Quéré
1103:Maria Fitzgerald
1088:Marcus du Sautoy
1083:Christl Donnelly
1053:Sarah Cleaveland
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52:Workman in 2016
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1320:Svante Pääbo
1274:Adair Turner
1258:Paul Workman
1257:
1243:Alison Smith
1238:Ted Shepherd
1208:Luke O'Neill
1123:Patrick Gill
1113:Pratibha Gai
1043:John Burrows
947:. Retrieved
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361:cancer cells
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304:Honorary DSc
288:Biochemistry
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270:Paul Workman
231:Paul Workman
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162:Institutions
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121:Cancer drugs
25:Paul Workman
18:
1356:1952 births
1325:Pasko Rakic
1290:Robert Cava
1248:David Wales
1223:Jim Prosser
1183:David Lodge
1178:Mark Lemmon
1158:David Hight
1128:Anne Glover
1098:Artur Ekert
1073:Jack Cuzick
1033:Graham Bell
1013:Chris Abell
481:. Icr.ac.uk
258:In London.
87:Nationality
1350:Categories
1315:John Hayes
1300:Mark Davis
1198:Gil McVean
1138:Ian Graham
1093:Jim Dunlop
1078:Bill David
458:14 October
402:References
286:degree in
276:Workington
75:Workington
64:1952-03-30
1295:Vint Cerf
1068:Brian Cox
927:6 October
629:890636199
565:0008-5472
81:, England
1267:Honorary
1133:Neil Gow
997:elected
882:18413753
811:(5): i.
740:24919912
573:15930314
294:and his
250:. He is
248:oncology
1283:Foreign
1163:Sue Ion
1006:Fellows
999:in 2016
993:of the
991:Fellows
949:24 June
902:4 April
839:4 April
718:Bibcode
485:4 April
290:at the
280:Cumbria
243:FMedSci
205:Website
145:FMedSci
90:British
79:Cumbria
38:FMedSci
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710:Nature
689:8 July
660:8 July
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522:8 July
430:
381:(FRSC)
195:(1976)
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184:Thesis
147:(2002)
141:(2010)
135:(2016)
126:Awards
679:(PDF)
646:(PDF)
514:(5).
504:(PDF)
384:2010
365:Hsp90
241:
237:
110:(PhD)
104:(BSc)
36:
32:
951:2014
929:2018
904:2012
878:PMID
841:2012
782:ISBN
736:PMID
691:2014
662:2014
625:OCLC
600:ISBN
569:PMID
561:ISSN
524:2014
487:2012
460:2016
428:ISBN
239:FRSC
212:.icr
139:FRSC
58:Born
34:FRSC
868:doi
813:doi
774:doi
726:doi
714:510
592:doi
551:doi
420:doi
354:ICR
342:ICR
296:PhD
284:BSc
254:of
235:FRS
216:.uk
214:.ac
210:www
133:FRS
30:FRS
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436:.
422::
62:(
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