373:
350:
247:
272:
379:
278:
40:
2786:
Jagadeeswaran R, Surawska H, Krishnaswamy S, Janamanchi V, Mackinnon AC, Seiwert TY, Loganathan S, Kanteti R, Reichman T, Nallasura V, Schwartz S, Faoro L, Wang YC, Girard L, Tretiakova MS, Ahmed S, Zumba O, Soulii L, Bindokas VP, Szeto LL, Gordon GJ, Bueno R, Sugarbaker D, Lingen MW, Sattler M,
66:
1487:
and actopaxin, and regulators of actin organization, such as COOL/PIX and PKL/GIT. Paxillin is tyrosine-phosphorylated by FAK and Src upon integrin engagement or growth factor stimulation, creating binding sites for the adapter protein
2961:
Turner CE, Miller JT (June 1994). "Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region".
2424:
Gehmlich K, Pinotsis N, Hayess K, van der Ven PF, Milting H, El
Banayosy A, Körfer R, Wilmanns M, Ehler E, Fürst DO (June 2007). "Paxillin and ponsin interact in nascent costameres of muscle cells".
3976:
3047:"Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding"
1559:. While the precise functions of paxillin in this process are still being unveiled, studies investigating binding partners of paxillin have provided mechanistic understanding of its function. The
3642:"Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin"
3510:
Salgia R, Sattler M, Pisick E, Li JL, Griffin JD (February 1996). "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl".
1713:
Paxillin has been shown to have a clinically-significant role in patients with several cancer types. Enhanced expression of paxillin has been detected in premalignant areas of
3566:
Retta SF, Barry ST, Critchley DR, Defilippi P, Silengo L, Tarone G (December 1996). "Focal adhesion and stress fiber formation is regulated by tyrosine phosphatase activity".
2926:
Wood CK, Turner CE, Jackson P, Critchley DR (February 1994). "Characterisation of the paxillin-binding site and the C-terminal focal adhesion targeting sequence in vinculin".
2337:
Decker ML, Simpson DG, Behnke M, Cook MG, Decker RS (July 1990). "Morphological analysis of contracting and quiescent adult rabbit cardiac myocytes in long-term culture".
3969:
386:
285:
1898:
3790:"Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells"
3383:"Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading"
3962:
3886:
1476:
2037:"Intact LIM 3 and LIM 4 domains of paxillin are required for the association to a novel polyproline region (Pro 2) of protein-tyrosine phosphatase-PEST"
943:
208:
924:
1471:. The N-terminal region of paxillin is rich in protein–protein interaction sites. The proteins that bind to paxillin are diverse and include protein
2838:"Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif"
2508:
Zemljic-Harpf AE, Miller JC, Henderson SA, Wright AT, Manso AM, Elsherif L, Dalton ND, Thor AK, Perkins GA, McCulloch AD, Ross RS (November 2007).
1975:
Herreros L, Rodríguez-Fernandez JL, Brown MC, Alonso-Lebrero JL, Cabañas C, Sánchez-Madrid F, Longo N, Turner CE, Sánchez-Mateos P (August 2000).
4199:
1880:
1862:
63:
4012:
1235:
372:
3993:
2998:"Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase"
1452:
1242:
2510:"Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy"
349:
4088:
1976:
2739:"Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease"
1849:
1828:
3607:"Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins"
4108:
271:
246:
3533:"p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene"
2737:
Mackinnon AC, Tretiakova M, Henderson L, Mehta RG, Yan BC, Joseph L, Krausz T, Husain AN, Reid ME, Salgia R (January 2011).
1845:
2461:"Serine-910 phosphorylation of focal adhesion kinase is critical for sarcomere reorganization in cardiomyocyte hypertrophy"
2076:
Brown MC, Curtis MS, Turner CE (August 1998). "Paxillin LD motifs may define a new family of protein recognition domains".
1906:
1824:
3954:
188:
3893:
3346:
Salgia R, Uemura N, Okuda K, Li JL, Pisick E, Sattler M, de Jong R, Druker B, Heisterkamp N, Chen LB (December 1995).
1753:
1698:
1977:"Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton"
4001:
385:
284:
3531:
Salgia R, Pisick E, Sattler M, Li JL, Uemura N, Wong WK, Burky SA, Hirai H, Chen LB, Griffin JD (October 1996).
2641:"Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1"
378:
277:
3906:
988:
196:
2168:
Salgia R, Li JL, Lo SH, Brunkhorst B, Kansas GS, Sobhany ES, Sun Y, Pisick E, Hallek M, Ernst T (March 1995).
1328:
as well as abnormal expression of paxillin protein has been implicated in the progression of various cancers.
3174:"Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion"
2459:
Chu M, Iyengar R, Koshman YE, Kim T, Russell B, Martin JL, Heroux AL, Robia SL, Samarel AM (December 2011).
1744:. Paxillin plays a role in the MET tyrosine kinase signaling pathway, which is upregulated in many cancers.
969:
2600:"Activation of pyk2/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling"
1737:
have been associated with enhanced tumor growth, cell proliferation, and invasion in lung cancer tissues.
3223:"Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions"
2787:
Krausz T, Vigneswaran W, Natarajan V, Minna J, Vokes EE, Ferguson MK, Husain AN, Salgia R (January 2008).
1690:
1666:
1628:
3677:"Paxillin phosphorylation and association with Lck and Pyk2 in anti-CD3- or anti-CD45-stimulated T cells"
2559:"A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes"
2690:"Hic-5 is required for fetal gene expression and cytoskeletal organization of neonatal cardiac myocytes"
1480:
260:
2789:"Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion"
1516:
1489:
1321:
175:
2639:
Sussman MA, Welch S, Walker A, Klevitsky R, Hewett TE, Price RL, Schaefer E, Yager K (April 2000).
1730:
1718:
1694:
1632:
1449:
1218:
1214:
1204:
1200:
1196:
1165:
1161:
1110:
1106:
1102:
1098:
1094:
1090:
1086:
1082:
1078:
1068:
1056:
1052:
4169:
3741:
3469:"Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton"
3426:"Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains"
3334:
3297:
3268:"Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration"
3154:
2362:
2150:
2101:
2017:
1631:. Additional studies have shown that paxillin itself is phosphorylated, and this participates in
1571:, which occurs after the onset of the myogenic differentiation and with expression restricted to
220:
1192:
1188:
1173:
1169:
1135:
1131:
1064:
1060:
2598:
Melendez J, Welch S, Schaefer E, Moravec CS, Avraham S, Avraham H, Sussman MA (November 2002).
4204:
3934:
3913:
3881:
3862:
3819:
3776:
3733:
3698:
3663:
3628:
3593:
3554:
3519:
3498:
3455:
3412:
3369:
3326:
3289:
3244:
3203:
3146:
3111:
3076:
3027:
2978:
2943:
2908:
2859:
2818:
2768:
2719:
2670:
2621:
2580:
2539:
2490:
2441:
2403:
2354:
2319:
2278:
2226:
2191:
2142:
2093:
2058:
2009:
1954:
168:
56:
3467:
Yoshida M, Westlin WF, Wang N, Ingber DE, Rosenzweig A, Resnick N, Gimbrone MA (April 1996).
2170:"Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL"
3852:
3844:
3809:
3801:
3766:
3723:
3688:
3653:
3618:
3583:
3575:
3544:
3488:
3480:
3445:
3437:
3402:
3394:
3359:
3318:
3279:
3234:
3193:
3185:
3138:
3103:
3066:
3058:
3017:
3009:
2970:
2935:
2898:
2890:
2849:
2808:
2800:
2758:
2750:
2709:
2701:
2660:
2652:
2611:
2570:
2529:
2521:
2480:
2472:
2433:
2393:
2346:
2309:
2298:"Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase"
2268:
2260:
2218:
2181:
2132:
2085:
2048:
2001:
1991:
1944:
1740:
During tumor transformation, a consistent finding is that paxillin protein is recruited and
465:
396:
340:
295:
2382:"Focal adhesion kinase is essential for costamerogenesis in cultured skeletal muscle cells"
3989:
3897:
1674:
1655:
1651:
1604:
1580:
1540:
1532:
1496:
1472:
1385:-rich sequences termed LD motifs, which mediate several interactions, including that with
1371:
1317:
440:
3712:"Syk activation is required for spreading and H2O2 release in adherent human neutrophils"
216:
1701:, paxillin expression levels increased, suggesting a role for paxillin in both types of
1677:
and cleavage of paxillin. Similarly, paxillin was shown to have altered localization in
4103:
4061:
3985:
3857:
3832:
3493:
3468:
3450:
3425:
3309:
Rose DM, Han J, Ginsberg MH (August 2002). "Alpha4 integrins and the immune response".
3198:
3173:
3071:
3046:
2903:
2878:
2813:
2788:
2763:
2738:
2714:
2689:
2534:
2509:
2485:
2460:
2273:
2248:
1741:
1702:
1504:
1464:
1456:
1309:
3814:
3789:
3407:
3382:
3022:
2997:
2665:
2640:
2222:
2137:
2120:
1519:. The current working model of costamerogenesis is that in cultured, undifferentiated
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
706:
701:
696:
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686:
681:
676:
671:
666:
661:
656:
4193:
4022:
3943:
3922:
3322:
1678:
1662:
1644:
1640:
1636:
1600:
1544:
1433:
643:
3902:
3805:
3745:
3338:
3301:
3158:
2366:
2154:
1689:
organization, in part via paxillin redistribution, may be a pathogenic mechanism in
1547:. Premyofibrils become nascent myofibrils, which progressively align to form mature
39:
2105:
2021:
1670:
458:
237:
200:
2804:
3728:
3711:
224:
4174:
2705:
2398:
2381:
1885:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1867:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1722:
1714:
1467:. It is presumed through a direct association with the cytoplasmic tail of beta-
1402:
1394:
1348:
1337:
541:
2437:
1784:
1564:
1548:
1512:
1460:
1422:
1418:
1414:
1406:
1378:
1351:
1344:
357:
254:
204:
3771:
3755:"Integrins regulate the association and phosphorylation of paxillin by c-Abl"
3754:
3658:
3641:
3549:
3532:
3364:
3347:
2314:
2297:
2053:
2036:
1673:
overexpression, paxillin distribution was revamped coordinate with increased
4083:
3693:
3676:
3623:
3606:
3348:"CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells"
3107:
2754:
2186:
2169:
1949:
1932:
1726:
1686:
1624:
1620:
1608:
1596:
1572:
1556:
1552:
1536:
1508:
1500:
1359:
1313:
888:
601:
479:
424:
411:
323:
310:
212:
22:
3890:
3866:
3579:
3441:
3330:
3293:
3248:
3239:
3222:
3207:
3189:
3150:
3115:
3062:
2974:
2912:
2854:
2837:
2822:
2772:
2723:
2674:
2625:
2616:
2599:
2584:
2575:
2558:
2543:
2494:
2445:
2407:
2264:
2146:
2062:
2013:
1996:
1933:"Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin"
3823:
3780:
3737:
3702:
3667:
3632:
3597:
3558:
3523:
3502:
3484:
3459:
3416:
3373:
3080:
3031:
2982:
2947:
2939:
2894:
2863:
2358:
2350:
2323:
2282:
2230:
2195:
2097:
1958:
1615:-paxillin interaction is likely inversely related to the stability of the
1611:
of paxillin. This is important to understand because the stability of the
1282:
1277:
4078:
3398:
2525:
2476:
1931:
Shen Y, Schneider G, Cloutier JF, Veillette A, Schaller MD (March 1998).
1772:
1648:
1616:
1528:
1520:
1484:
1468:
1425:
1390:
1355:
1266:
1033:
1014:
3013:
2005:
3948:
3938:
3927:
3917:
3848:
1766:
1619:-paxillin interaction, which would likely indicate the strength of the
1560:
1429:
1410:
1398:
1382:
1367:
1298:
1000:
955:
3788:
Ganju RK, Munshi N, Nair BC, Liu ZY, Gill P, Groopman JE (July 1998).
3588:
1499:
cells, paxillin is important in costamerogenesis, or the formation of
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
4151:
3142:
3129:
Turner CE (December 2000). "Paxillin and focal adhesion signalling".
2249:"Paxillin: a new vinculin-binding protein present in focal adhesions"
1789:
1760:
1588:
1568:
1539:
occurs, and premyofibrils assemble at structures that are typical of
1363:
1250:
910:
3284:
3267:
2656:
1555:
structures appear. Costameric proteins redistribute to form mature
1362:-rich with conserved repeats; these serve as binding sites for the
4138:
4133:
4128:
4123:
4118:
4113:
4098:
4071:
4066:
4041:
3640:
Hiregowdara D, Avraham H, Fu Y, London R, Avraham S (April 1997).
3424:
Schaller MD, Otey CA, Hildebrand JD, Parsons JT (September 1995).
1795:
1543:
in non-muscle cells; a similar phenomenon is observed in cultured
1524:
2089:
873:
869:
4156:
4146:
4036:
4031:
1778:
1682:
1612:
1592:
1584:
1576:
1437:
1386:
1305:
192:
3958:
1535:. During early differentiation, premyofibril formation through
1801:
1693:. In addition, in mice subjected to pressure overload-induced
809:
vascular endothelial growth factor receptor signaling pathway
3933:
Overview of all the structural information available in the
3912:
Overview of all the structural information available in the
3381:
Bergman M, Joukov V, Virtanen I, Alitalo K (February 1995).
2211:
1563:-rich region of paxillin specifically binds to the second
829:
transforming growth factor beta receptor signaling pathway
1595:
with paxillin, and controls the stability of paxillin at
1681:
from transgenic mice expressing a constitutively-active
448:
3675:
Ostergaard HL, Lou O, Arendt CW, Berg NN (March 1998).
2879:"MET molecular mechanisms and therapies in lung cancer"
1903:
Cardiac
Organellar Protein Atlas Knowledgebase (COPaKB)
1336:
Human paxillin is 64.5 kDa in molecular weight and 591
1531:
and paxillin are in complex and located primarily at
1405:
to form a hydrophobic protein-binding interface. The
1347:
region of paxillin is composed of four tandem double
613:
3094:
Turner CE (December 2000). "Paxillin interactions".
2996:
Hildebrand JD, Schaller MD, Parsons JT (June 1995).
2119:
Tumbarello DA, Brown MC, Turner CE (February 2002).
1899:"Protein sequence of human PXN (Uniprot ID: P49023)"
1627:
reorganization; processes which have been linked to
4050:
4021:
4000:
1187:
1154:
1124:
1051:
3045:Brown MC, Perrotta JA, Turner CE (November 1996).
2836:Vande Pol SB, Brown MC, Turner CE (January 1998).
1841:
1839:
1837:
1820:
1818:
1816:
1393:. The LD motifs are predicted to form amphipathic
859:regulation of nucleic acid-templated transcription
794:epidermal growth factor receptor signaling pathway
1579:is critical for directing paxillin function. The
395:
294:
2419:
2417:
1459:The C-terminal region of paxillin contains four
1970:
1968:
1575:. We also know that the binding of paxillin to
1320:cells, and it functions to adhere cells to the
18:Protein-coding gene in the species Homo sapiens
2242:
2240:
1846:GRCm38: Ensembl release 89: ENSMUSG00000029528
3970:
2557:Taylor JM, Rovin JD, Parsons JT (June 2000).
2296:Bellis SL, Miller JT, Turner CE (July 1995).
2035:Côté JF, Turner CE, Tremblay ML (July 1999).
1661:The structural reorganization of paxillin in
1507:-like structures in muscle cells that tether
1381:region of paxillin has five highly conserved
8:
3605:Mazaki Y, Hashimoto S, Sabe H (March 1997).
3172:Nikolopoulos SN, Turner CE (December 2000).
2694:Journal of Molecular and Cellular Cardiology
2688:Yund EE, Hill JA, Keller RS (October 2009).
849:positive regulation of stress fiber assembly
804:cellular response to reactive oxygen species
1926:
1924:
1825:GRCh38: Ensembl release 89: ENSG00000089159
854:substrate adhesion-dependent cell spreading
4054:
3977:
3963:
3955:
2247:Turner CE, Glenney JR, Burridge K (1990).
1665:has also been detected in mouse models of
1184:
1048:
884:
639:
436:
335:
232:
74:
3905:at the U.S. National Library of Medicine
3856:
3813:
3770:
3727:
3692:
3657:
3622:
3587:
3548:
3492:
3449:
3406:
3363:
3283:
3238:
3197:
3070:
3021:
2902:
2853:
2812:
2762:
2713:
2664:
2615:
2574:
2533:
2484:
2397:
2313:
2272:
2185:
2136:
2052:
1995:
1948:
819:growth hormone receptor signaling pathway
3221:Nikolopoulos SN, Turner CE (June 2001).
2209:Turner CE (September 1998). "Paxillin".
1654:paxillin, which was mediated by protein
1455:discovered in 1990 in the laboratory of
1812:
21:Not to be confused with the neurotoxin
1685:. These data show that alterations in
1432:motifs may serve as binding sites for
1401:residue positioned on one face of the
1370:and serves as the targeting motif for
29:
2645:The Journal of Clinical Investigation
400:
361:
356:
299:
258:
253:
7:
3831:Deakin NO, Turner CE (August 2008).
3710:Fernandez R, Suchard SJ (May 1998).
1725:, as well as dysplastic lesions and
1413:-rich domain that has potential for
568:endothelial cell of lymphatic vessel
556:vestibular membrane of cochlear duct
3994:signal transducing adaptor proteins
3759:The Journal of Biological Chemistry
3753:Lewis JM, Schwartz MA (June 1998).
3681:The Journal of Biological Chemistry
3646:The Journal of Biological Chemistry
3611:The Journal of Biological Chemistry
3537:The Journal of Biological Chemistry
3352:The Journal of Biological Chemistry
3227:The Journal of Biological Chemistry
2604:The Journal of Biological Chemistry
2563:The Journal of Biological Chemistry
2302:The Journal of Biological Chemistry
2174:The Journal of Biological Chemistry
2041:The Journal of Biological Chemistry
1984:The Journal of Biological Chemistry
1937:The Journal of Biological Chemistry
1591:-910 regulates the interaction of
1151:
1121:
1024:
1005:
979:
960:
934:
915:
707:transcription coregulator activity
667:protein-containing complex binding
618:
536:
474:
453:
14:
1364:protein tyrosine phosphatase-PEST
1301:that in humans is encoded by the
4089:Death-inducing signaling complex
3323:10.1034/j.1600-065X.2002.18611.x
692:ubiquitin protein ligase binding
384:
377:
371:
348:
283:
276:
270:
245:
38:
3806:10.1128/JVI.72.7.6131-6137.1998
2380:Quach NL, Rando TA (May 2006).
1647:stimulated a rapid increase in
1643:with the hypertrophic agonist,
1483:, structural proteins, such as
3387:Molecular and Cellular Biology
2877:Lawrence RE, Salgia R (2010).
2514:Molecular and Cellular Biology
738:microtubule associated complex
602:More reference expression data
1:
3002:Molecular Biology of the Cell
2883:Cell Adhesion & Migration
2805:10.1158/0008-5472.CAN-07-1998
2743:Journal of Clinical Pathology
2223:10.1016/s1357-2725(98)00062-4
2138:10.1016/s0014-5793(01)03244-6
1312:of non-striated cells and at
514:muscle layer of sigmoid colon
369:
268:
4200:Genes on human chromosome 12
3729:10.4049/jimmunol.160.10.5154
2426:Journal of Molecular Biology
3473:The Journal of Cell Biology
3430:The Journal of Cell Biology
3266:Panetti TS (January 2002).
3178:The Journal of Cell Biology
3051:The Journal of Cell Biology
2706:10.1016/j.yjmcc.2009.06.006
2399:10.1016/j.ydbio.2005.12.040
1752:Paxillin has been shown to
1729:in high-risk patients with
1699:hypertrophic cardiomyopathy
1577:focal adhesion kinase (FAK)
1481:focal adhesion kinase (FAK)
1308:. Paxillin is expressed at
702:protein phosphatase binding
4221:
4013:JAK-STAT signaling pathway
3896:December 11, 2014, at the
3568:Experimental Cell Research
1236:Chr 12: 120.21 – 120.27 Mb
844:endothelial cell migration
572:retinal pigment epithelium
20:
4165:
4057:
2438:10.1016/j.jmb.2007.03.050
2078:Nature Structural Biology
1881:"Mouse PubMed Reference:"
1863:"Human PubMed Reference:"
1281:
1276:
1272:
1265:
1249:
1243:Chr 5: 115.64 – 115.69 Mb
1230:
1211:
1158:
1147:
1128:
1075:
1044:
1031:
1027:
1012:
1008:
999:
986:
982:
967:
963:
954:
941:
937:
922:
918:
909:
894:
887:
883:
867:
642:
638:
626:
621:
612:
599:
548:
539:
486:
477:
447:
439:
435:
418:
405:
368:
347:
338:
334:
317:
304:
267:
244:
235:
231:
186:
183:
173:
166:
161:
82:
77:
60:
55:
50:
46:
37:
32:
3947:(Mouse Paxillin) at the
3926:(Human Paxillin) at the
3907:Medical Subject Headings
3772:10.1074/jbc.273.23.14225
3659:10.1074/jbc.272.16.10804
3550:10.1074/jbc.271.41.25198
3365:10.1074/jbc.270.49.29145
2315:10.1074/jbc.270.29.17437
2121:"The paxillin LD motifs"
2054:10.1074/jbc.274.29.20550
1503:, which are specialized
1463:that target paxillin to
3889:Info with links in the
3837:Journal of Cell Science
3833:"Paxillin comes of age"
3694:10.1074/jbc.273.10.5692
3624:10.1074/jbc.272.11.7437
3512:Experimental Hematology
3272:Frontiers in Bioscience
3108:10.1242/jcs.113.23.4139
3096:Journal of Cell Science
2963:Journal of Cell Science
2928:Journal of Cell Science
2755:10.1136/jcp.2010.075853
2465:Cardiovascular Research
2187:10.1074/jbc.270.10.5039
1950:10.1074/jbc.273.11.6474
1623:interaction as well as
799:signal complex assembly
564:external carotid artery
560:internal carotid artery
518:upper lobe of left lung
179:, entrez:5829, paxillin
4025:receptor-bound protein
3891:Cell Migration Gateway
3580:10.1006/excr.1996.0376
3442:10.1083/jcb.130.5.1181
3240:10.1074/jbc.M102163200
3190:10.1083/jcb.151.7.1435
3063:10.1083/jcb.135.4.1109
2975:10.1242/jcs.107.6.1583
2855:10.1038/sj.onc.1201504
2617:10.1074/jbc.M204886200
2576:10.1074/jbc.M909099199
2265:10.1083/jcb.111.3.1059
1997:10.1074/jbc.M003970200
1723:goblet cell metaplasia
1691:dilated cardiomyopathy
1669:. In a mouse model of
1667:dilated cardiomyopathy
1635:signaling pathways in
1629:dilated cardiomyopathy
1511:structures across the
687:protein kinase binding
3716:Journal of Immunology
3485:10.1083/jcb.133.2.445
3311:Immunological Reviews
2940:10.1242/jcs.107.2.709
2895:10.4161/cam.4.1.10973
2386:Developmental Biology
2351:10.1002/ar.1092270303
2339:The Anatomical Record
1709:Clinical significance
261:Chromosome 12 (human)
3399:10.1128/mcb.15.2.711
2526:10.1128/MCB.00728-07
1517:extracellular matrix
1322:extracellular matrix
824:cell-matrix adhesion
657:beta-catenin binding
506:gastrocnemius muscle
363:Chromosome 5 (mouse)
78:List of PDB id codes
51:Available structures
3794:Journal of Virology
3131:Nature Cell Biology
3014:10.1091/mbc.6.6.637
1731:lung adenocarcinoma
1719:squamous metaplasia
1695:cardiac hypertrophy
1450:signal transduction
839:response to peptide
834:signal transduction
510:canal of the cervix
3849:10.1242/jcs.018044
3843:(Pt 15): 2435–44.
2477:10.1093/cvr/cvr247
1409:region also has a
989:ENSMUSG00000029528
789:muscle contraction
782:Biological process
716:Cellular component
697:neuropilin binding
650:Molecular function
584:tibiofemoral joint
402:5 F|5 56.1 cM
4187:
4186:
4183:
4182:
3543:(41): 25198–203.
3233:(26): 23499–505.
1292:
1291:
1288:
1287:
1261:
1260:
1226:
1225:
1181:
1180:
1143:
1142:
1118:
1117:
1040:
1039:
1021:
1020:
995:
994:
976:
975:
950:
949:
931:
930:
879:
878:
773:adherens junction
672:metal ion binding
634:
633:
630:
629:
608:
607:
595:
594:
533:
532:
498:left uterine tube
431:
430:
330:
329:
157:
156:
153:
152:
61:Ortholog search:
4212:
4055:
3990:carrier proteins
3979:
3972:
3965:
3956:
3882:MBInfo: Paxillin
3870:
3860:
3827:
3817:
3784:
3774:
3765:(23): 14225–30.
3749:
3731:
3706:
3696:
3671:
3661:
3652:(16): 10804–10.
3636:
3626:
3601:
3591:
3562:
3552:
3527:
3506:
3496:
3463:
3453:
3420:
3410:
3377:
3367:
3358:(49): 29145–50.
3342:
3305:
3287:
3278:(1–3): d143-50.
3253:
3252:
3242:
3218:
3212:
3211:
3201:
3169:
3163:
3162:
3143:10.1038/35046659
3126:
3120:
3119:
3091:
3085:
3084:
3074:
3042:
3036:
3035:
3025:
2993:
2987:
2986:
2958:
2952:
2951:
2923:
2917:
2916:
2906:
2874:
2868:
2867:
2857:
2833:
2827:
2826:
2816:
2783:
2777:
2776:
2766:
2734:
2728:
2727:
2717:
2685:
2679:
2678:
2668:
2636:
2630:
2629:
2619:
2610:(47): 45203–10.
2595:
2589:
2588:
2578:
2554:
2548:
2547:
2537:
2505:
2499:
2498:
2488:
2456:
2450:
2449:
2421:
2412:
2411:
2401:
2377:
2371:
2370:
2334:
2328:
2327:
2317:
2308:(29): 17437–41.
2293:
2287:
2286:
2276:
2244:
2235:
2234:
2206:
2200:
2199:
2189:
2165:
2159:
2158:
2140:
2116:
2110:
2109:
2073:
2067:
2066:
2056:
2047:(29): 20550–60.
2032:
2026:
2025:
1999:
1990:(34): 26436–40.
1981:
1972:
1963:
1962:
1952:
1928:
1919:
1918:
1916:
1914:
1909:on July 13, 2015
1905:. Archived from
1895:
1889:
1888:
1877:
1871:
1870:
1859:
1853:
1843:
1832:
1822:
1656:tyrosine kinases
1537:sarcomerogenesis
1525:alpha-5 integrin
1473:tyrosine kinases
1274:
1273:
1245:
1238:
1221:
1185:
1176:
1152:
1148:RefSeq (protein)
1138:
1122:
1113:
1049:
1025:
1006:
980:
961:
935:
916:
885:
677:integrin binding
662:vinculin binding
640:
619:
604:
588:stria vascularis
544:
542:Top expressed in
537:
526:transverse colon
482:
480:Top expressed in
475:
454:
437:
427:
414:
403:
388:
381:
375:
364:
352:
336:
326:
313:
302:
287:
280:
274:
263:
249:
233:
227:
178:
171:
148:
75:
69:
48:
47:
42:
30:
4220:
4219:
4215:
4214:
4213:
4211:
4210:
4209:
4190:
4189:
4188:
4179:
4161:
4046:
4017:
3996:
3983:
3898:Wayback Machine
3878:
3873:
3830:
3787:
3752:
3722:(10): 5154–62.
3709:
3674:
3639:
3617:(11): 7437–44.
3604:
3565:
3530:
3509:
3466:
3423:
3380:
3345:
3308:
3285:10.2741/panetti
3265:
3261:
3259:Further reading
3256:
3220:
3219:
3215:
3171:
3170:
3166:
3128:
3127:
3123:
3102:(23): 4139–40.
3093:
3092:
3088:
3044:
3043:
3039:
2995:
2994:
2990:
2960:
2959:
2955:
2925:
2924:
2920:
2876:
2875:
2871:
2835:
2834:
2830:
2793:Cancer Research
2785:
2784:
2780:
2736:
2735:
2731:
2687:
2686:
2682:
2657:10.1172/JCI8497
2638:
2637:
2633:
2597:
2596:
2592:
2569:(25): 19250–7.
2556:
2555:
2551:
2520:(21): 7522–37.
2507:
2506:
2502:
2458:
2457:
2453:
2423:
2422:
2415:
2379:
2378:
2374:
2336:
2335:
2331:
2295:
2294:
2290:
2246:
2245:
2238:
2208:
2207:
2203:
2180:(10): 5039–47.
2167:
2166:
2162:
2118:
2117:
2113:
2075:
2074:
2070:
2034:
2033:
2029:
1979:
1974:
1973:
1966:
1943:(11): 6474–81.
1930:
1929:
1922:
1912:
1910:
1897:
1896:
1892:
1879:
1878:
1874:
1861:
1860:
1856:
1844:
1835:
1823:
1814:
1810:
1750:
1733:. Mutations in
1711:
1675:phosphorylation
1652:phosphorylation
1639:. Treatment of
1605:phosphorylation
1581:phosphorylation
1541:focal adhesions
1533:focal adhesions
1497:striated muscle
1465:focal adhesions
1453:adaptor protein
1446:
1372:focal adhesions
1334:
1324:. Mutations in
1318:striated muscle
1310:focal adhesions
1283:View/Edit Mouse
1278:View/Edit Human
1241:
1234:
1231:Location (UCSC)
1217:
1213:
1207:
1203:
1199:
1195:
1191:
1172:
1168:
1164:
1160:
1134:
1130:
1109:
1105:
1101:
1097:
1093:
1089:
1085:
1081:
1077:
1071:
1067:
1063:
1059:
1055:
970:ENSG00000089159
863:
777:
728:plasma membrane
711:
682:protein binding
600:
591:
586:
582:
578:
576:right lung lobe
574:
570:
566:
562:
558:
554:
540:
529:
524:
520:
516:
512:
508:
504:
500:
496:
492:
478:
422:
409:
401:
391:
390:
389:
382:
362:
339:Gene location (
321:
308:
300:
290:
289:
288:
281:
259:
236:Gene location (
225:PXN - orthologs
187:
174:
167:
84:
62:
26:
19:
12:
11:
5:
4218:
4216:
4208:
4207:
4202:
4192:
4191:
4185:
4184:
4181:
4180:
4178:
4177:
4172:
4166:
4163:
4162:
4160:
4159:
4154:
4149:
4144:
4143:
4142:
4136:
4131:
4126:
4121:
4116:
4106:
4101:
4096:
4091:
4086:
4081:
4076:
4075:
4074:
4069:
4058:
4052:
4048:
4047:
4045:
4044:
4039:
4034:
4028:
4026:
4019:
4018:
4016:
4015:
4006:
4004:
3998:
3997:
3986:Cell signaling
3984:
3982:
3981:
3974:
3967:
3959:
3953:
3952:
3931:
3910:
3900:
3884:
3877:
3876:External links
3874:
3872:
3871:
3828:
3785:
3750:
3707:
3687:(10): 5692–6.
3672:
3637:
3602:
3563:
3528:
3507:
3464:
3421:
3378:
3343:
3306:
3262:
3260:
3257:
3255:
3254:
3213:
3184:(7): 1435–48.
3164:
3137:(12): E231-6.
3121:
3086:
3057:(4): 1109–23.
3037:
2988:
2969:(6): 1583–91.
2953:
2918:
2869:
2828:
2778:
2729:
2680:
2631:
2590:
2549:
2500:
2451:
2413:
2372:
2329:
2288:
2259:(3): 1059–68.
2236:
2201:
2160:
2111:
2068:
2027:
1964:
1920:
1890:
1872:
1854:
1833:
1811:
1809:
1806:
1805:
1804:
1799:
1793:
1787:
1782:
1776:
1770:
1764:
1749:
1746:
1742:phosphorylated
1710:
1707:
1703:cardiomyopathy
1679:cardiomyocytes
1663:cardiomyocytes
1641:cardiomyocytes
1637:cardiomyocytes
1601:cardiomyocytes
1545:cardiomyocytes
1505:focal adhesion
1457:Keith Burridge
1448:Paxillin is a
1445:
1442:
1333:
1330:
1290:
1289:
1286:
1285:
1280:
1270:
1269:
1263:
1262:
1259:
1258:
1256:
1254:
1247:
1246:
1239:
1232:
1228:
1227:
1224:
1223:
1209:
1208:
1182:
1179:
1178:
1156:
1155:
1149:
1145:
1144:
1141:
1140:
1126:
1125:
1119:
1116:
1115:
1073:
1072:
1046:
1042:
1041:
1038:
1037:
1029:
1028:
1022:
1019:
1018:
1010:
1009:
1003:
997:
996:
993:
992:
984:
983:
977:
974:
973:
965:
964:
958:
952:
951:
948:
947:
939:
938:
932:
929:
928:
920:
919:
913:
907:
906:
901:
896:
892:
891:
881:
880:
877:
876:
865:
864:
862:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
785:
783:
779:
778:
776:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
723:focal adhesion
719:
717:
713:
712:
710:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
653:
651:
647:
646:
636:
635:
632:
631:
628:
627:
624:
623:
616:
610:
609:
606:
605:
597:
596:
593:
592:
590:
589:
585:
581:
577:
573:
569:
565:
561:
557:
553:
549:
546:
545:
534:
531:
530:
528:
527:
523:
522:body of uterus
519:
515:
511:
507:
503:
499:
495:
491:
487:
484:
483:
471:
470:
462:
451:
445:
444:
441:RNA expression
433:
432:
429:
428:
420:
416:
415:
407:
404:
399:
393:
392:
383:
376:
370:
366:
365:
360:
354:
353:
345:
344:
332:
331:
328:
327:
319:
315:
314:
306:
303:
298:
292:
291:
282:
275:
269:
265:
264:
257:
251:
250:
242:
241:
229:
228:
185:
181:
180:
172:
164:
163:
159:
158:
155:
154:
151:
150:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
17:
13:
10:
9:
6:
4:
3:
2:
4217:
4206:
4203:
4201:
4198:
4197:
4195:
4176:
4173:
4171:
4168:
4167:
4164:
4158:
4155:
4153:
4150:
4148:
4145:
4140:
4137:
4135:
4132:
4130:
4127:
4125:
4122:
4120:
4117:
4115:
4112:
4111:
4110:
4107:
4105:
4102:
4100:
4097:
4095:
4092:
4090:
4087:
4085:
4082:
4080:
4077:
4073:
4070:
4068:
4065:
4064:
4063:
4060:
4059:
4056:
4053:
4049:
4043:
4040:
4038:
4035:
4033:
4030:
4029:
4027:
4024:
4023:Growth factor
4020:
4014:
4011:
4008:
4007:
4005:
4003:
3999:
3995:
3991:
3987:
3980:
3975:
3973:
3968:
3966:
3961:
3960:
3957:
3950:
3946:
3945:
3940:
3936:
3932:
3929:
3925:
3924:
3919:
3915:
3911:
3908:
3904:
3901:
3899:
3895:
3892:
3888:
3885:
3883:
3880:
3879:
3875:
3868:
3864:
3859:
3854:
3850:
3846:
3842:
3838:
3834:
3829:
3825:
3821:
3816:
3811:
3807:
3803:
3800:(7): 6131–7.
3799:
3795:
3791:
3786:
3782:
3778:
3773:
3768:
3764:
3760:
3756:
3751:
3747:
3743:
3739:
3735:
3730:
3725:
3721:
3717:
3713:
3708:
3704:
3700:
3695:
3690:
3686:
3682:
3678:
3673:
3669:
3665:
3660:
3655:
3651:
3647:
3643:
3638:
3634:
3630:
3625:
3620:
3616:
3612:
3608:
3603:
3599:
3595:
3590:
3585:
3581:
3577:
3574:(2): 307–17.
3573:
3569:
3564:
3560:
3556:
3551:
3546:
3542:
3538:
3534:
3529:
3525:
3521:
3517:
3513:
3508:
3504:
3500:
3495:
3490:
3486:
3482:
3479:(2): 445–55.
3478:
3474:
3470:
3465:
3461:
3457:
3452:
3447:
3443:
3439:
3436:(5): 1181–7.
3435:
3431:
3427:
3422:
3418:
3414:
3409:
3404:
3400:
3396:
3393:(2): 711–22.
3392:
3388:
3384:
3379:
3375:
3371:
3366:
3361:
3357:
3353:
3349:
3344:
3340:
3336:
3332:
3328:
3324:
3320:
3316:
3312:
3307:
3303:
3299:
3295:
3291:
3286:
3281:
3277:
3273:
3269:
3264:
3263:
3258:
3250:
3246:
3241:
3236:
3232:
3228:
3224:
3217:
3214:
3209:
3205:
3200:
3195:
3191:
3187:
3183:
3179:
3175:
3168:
3165:
3160:
3156:
3152:
3148:
3144:
3140:
3136:
3132:
3125:
3122:
3117:
3113:
3109:
3105:
3101:
3097:
3090:
3087:
3082:
3078:
3073:
3068:
3064:
3060:
3056:
3052:
3048:
3041:
3038:
3033:
3029:
3024:
3019:
3015:
3011:
3008:(6): 637–47.
3007:
3003:
2999:
2992:
2989:
2984:
2980:
2976:
2972:
2968:
2964:
2957:
2954:
2949:
2945:
2941:
2937:
2934:(2): 709–17.
2933:
2929:
2922:
2919:
2914:
2910:
2905:
2900:
2896:
2892:
2889:(1): 146–52.
2888:
2884:
2880:
2873:
2870:
2865:
2861:
2856:
2851:
2847:
2843:
2839:
2832:
2829:
2824:
2820:
2815:
2810:
2806:
2802:
2799:(1): 132–42.
2798:
2794:
2790:
2782:
2779:
2774:
2770:
2765:
2760:
2756:
2752:
2748:
2744:
2740:
2733:
2730:
2725:
2721:
2716:
2711:
2707:
2703:
2699:
2695:
2691:
2684:
2681:
2676:
2672:
2667:
2662:
2658:
2654:
2651:(7): 875–86.
2650:
2646:
2642:
2635:
2632:
2627:
2623:
2618:
2613:
2609:
2605:
2601:
2594:
2591:
2586:
2582:
2577:
2572:
2568:
2564:
2560:
2553:
2550:
2545:
2541:
2536:
2531:
2527:
2523:
2519:
2515:
2511:
2504:
2501:
2496:
2492:
2487:
2482:
2478:
2474:
2471:(3): 409–19.
2470:
2466:
2462:
2455:
2452:
2447:
2443:
2439:
2435:
2432:(3): 665–82.
2431:
2427:
2420:
2418:
2414:
2409:
2405:
2400:
2395:
2391:
2387:
2383:
2376:
2373:
2368:
2364:
2360:
2356:
2352:
2348:
2345:(3): 285–99.
2344:
2340:
2333:
2330:
2325:
2321:
2316:
2311:
2307:
2303:
2299:
2292:
2289:
2284:
2280:
2275:
2270:
2266:
2262:
2258:
2254:
2250:
2243:
2241:
2237:
2232:
2228:
2224:
2220:
2216:
2212:
2205:
2202:
2197:
2193:
2188:
2183:
2179:
2175:
2171:
2164:
2161:
2156:
2152:
2148:
2144:
2139:
2134:
2130:
2126:
2122:
2115:
2112:
2107:
2103:
2099:
2095:
2091:
2087:
2083:
2079:
2072:
2069:
2064:
2060:
2055:
2050:
2046:
2042:
2038:
2031:
2028:
2023:
2019:
2015:
2011:
2007:
2003:
1998:
1993:
1989:
1985:
1978:
1971:
1969:
1965:
1960:
1956:
1951:
1946:
1942:
1938:
1934:
1927:
1925:
1921:
1908:
1904:
1900:
1894:
1891:
1886:
1882:
1876:
1873:
1868:
1864:
1858:
1855:
1851:
1847:
1842:
1840:
1838:
1834:
1830:
1826:
1821:
1819:
1817:
1813:
1807:
1803:
1800:
1797:
1794:
1791:
1788:
1786:
1783:
1780:
1777:
1774:
1771:
1768:
1765:
1762:
1759:
1758:
1757:
1755:
1747:
1745:
1743:
1738:
1736:
1732:
1728:
1724:
1720:
1716:
1708:
1706:
1704:
1700:
1696:
1692:
1688:
1684:
1680:
1676:
1672:
1668:
1664:
1659:
1657:
1653:
1650:
1646:
1645:phenylephrine
1642:
1638:
1634:
1630:
1626:
1622:
1618:
1614:
1610:
1607:reducing the
1606:
1602:
1598:
1594:
1590:
1586:
1582:
1578:
1574:
1570:
1566:
1562:
1558:
1554:
1550:
1546:
1542:
1538:
1534:
1530:
1526:
1522:
1518:
1514:
1510:
1506:
1502:
1498:
1493:
1491:
1486:
1482:
1478:
1474:
1470:
1466:
1462:
1458:
1454:
1451:
1443:
1441:
1439:
1435:
1431:
1427:
1424:
1420:
1416:
1412:
1408:
1404:
1400:
1396:
1395:alpha helices
1392:
1388:
1384:
1380:
1375:
1373:
1369:
1365:
1361:
1357:
1353:
1350:
1346:
1341:
1339:
1331:
1329:
1327:
1323:
1319:
1315:
1311:
1307:
1304:
1300:
1296:
1284:
1279:
1275:
1271:
1268:
1264:
1257:
1255:
1252:
1248:
1244:
1240:
1237:
1233:
1229:
1222:
1220:
1216:
1210:
1206:
1202:
1198:
1194:
1190:
1186:
1183:
1177:
1175:
1171:
1167:
1163:
1157:
1153:
1150:
1146:
1139:
1137:
1133:
1127:
1123:
1120:
1114:
1112:
1108:
1104:
1100:
1096:
1092:
1088:
1084:
1080:
1074:
1070:
1066:
1062:
1058:
1054:
1050:
1047:
1045:RefSeq (mRNA)
1043:
1036:
1035:
1030:
1026:
1023:
1017:
1016:
1011:
1007:
1004:
1002:
998:
991:
990:
985:
981:
978:
972:
971:
966:
962:
959:
957:
953:
946:
945:
940:
936:
933:
927:
926:
921:
917:
914:
912:
908:
905:
902:
900:
897:
893:
890:
886:
882:
875:
871:
866:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
814:cell adhesion
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
786:
784:
781:
780:
774:
771:
769:
766:
764:
761:
759:
758:lamellipodium
756:
754:
751:
749:
746:
744:
743:cell junction
741:
739:
736:
734:
731:
729:
726:
724:
721:
720:
718:
715:
714:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
654:
652:
649:
648:
645:
644:Gene ontology
641:
637:
625:
620:
617:
615:
611:
603:
598:
587:
583:
579:
575:
571:
567:
563:
559:
555:
551:
550:
547:
543:
538:
535:
525:
521:
517:
513:
509:
505:
502:apex of heart
501:
497:
493:
489:
488:
485:
481:
476:
473:
472:
469:
467:
463:
461:
460:
456:
455:
452:
450:
446:
442:
438:
434:
426:
421:
417:
413:
408:
398:
394:
387:
380:
374:
367:
359:
355:
351:
346:
342:
337:
333:
325:
320:
316:
312:
307:
297:
293:
286:
279:
273:
266:
262:
256:
252:
248:
243:
239:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
182:
177:
170:
165:
160:
149:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
28:
24:
16:
4093:
4009:
3942:
3921:
3840:
3836:
3797:
3793:
3762:
3758:
3719:
3715:
3684:
3680:
3649:
3645:
3614:
3610:
3571:
3567:
3540:
3536:
3518:(2): 310–3.
3515:
3511:
3476:
3472:
3433:
3429:
3390:
3386:
3355:
3351:
3314:
3310:
3275:
3271:
3230:
3226:
3216:
3181:
3177:
3167:
3134:
3130:
3124:
3099:
3095:
3089:
3054:
3050:
3040:
3005:
3001:
2991:
2966:
2962:
2956:
2931:
2927:
2921:
2886:
2882:
2872:
2848:(1): 43–52.
2845:
2841:
2831:
2796:
2792:
2781:
2749:(1): 16–24.
2746:
2742:
2732:
2700:(4): 520–7.
2697:
2693:
2683:
2648:
2644:
2634:
2607:
2603:
2593:
2566:
2562:
2552:
2517:
2513:
2503:
2468:
2464:
2454:
2429:
2425:
2392:(1): 38–52.
2389:
2385:
2375:
2342:
2338:
2332:
2305:
2301:
2291:
2256:
2253:J. Cell Biol
2252:
2217:(9): 955–9.
2214:
2210:
2204:
2177:
2173:
2163:
2131:(1): 114–8.
2128:
2125:FEBS Letters
2124:
2114:
2090:10.1038/1370
2084:(8): 677–8.
2081:
2077:
2071:
2044:
2040:
2030:
2006:10261/135387
1987:
1983:
1940:
1936:
1911:. Retrieved
1907:the original
1902:
1893:
1884:
1875:
1866:
1857:
1751:
1748:Interactions
1739:
1734:
1712:
1671:tropomodulin
1660:
1633:hypertrophic
1551:and nascent
1494:
1447:
1397:, with each
1376:
1342:
1335:
1325:
1302:
1294:
1293:
1219:NP_001389999
1215:NP_001389998
1212:
1205:NP_001389997
1201:NP_001389996
1197:NP_001389995
1166:NP_001230685
1162:NP_001074324
1159:
1129:
1111:NM_001385990
1107:NM_001385989
1103:NM_001385988
1099:NM_001385987
1095:NM_001385986
1091:NM_001385985
1087:NM_001385984
1083:NM_001385983
1079:NM_001385982
1076:
1069:NM_001385981
1057:NM_001243756
1053:NM_001080855
1032:
1013:
987:
968:
942:
923:
903:
898:
753:cytoskeleton
733:stress fiber
494:tibial nerve
464:
457:
423:115,694,046
410:115,644,735
322:120,265,771
309:120,210,439
184:External IDs
83:
27:
15:
1715:hyperplasia
1697:, inducing
1461:LIM domains
1419:SH3 binding
1403:alpha helix
1352:LIM domains
1349:zinc finger
1340:in length.
1338:amino acids
748:cell cortex
552:granulocyte
490:granulocyte
162:Identifiers
4194:Categories
3589:2318/37568
3317:: 118–24.
1852:, May 2017
1831:, May 2017
1808:References
1687:costameric
1597:costameres
1573:costameres
1565:SH3 domain
1557:costameres
1549:myofibrils
1513:sarcolemma
1501:costameres
1475:, such as
1423:N-terminal
1407:N-terminal
1379:N-terminal
1345:C-terminal
1314:costameres
468:(ortholog)
205:HomoloGene
4084:Cortactin
1727:carcinoma
1625:sarcomere
1621:costamere
1609:half-life
1553:costamere
1521:myoblasts
1438:v-Crk SH2
1360:histidine
1354:that are
1332:Structure
1193:NP_598676
1189:NP_035353
1174:NP_079433
1170:NP_002850
1136:NM_133915
1132:NM_011223
1065:NM_025157
1061:NM_002859
889:Orthologs
763:cytoplasm
580:left lung
213:GeneCards
23:paxilline
4205:Proteins
4094:Paxillin
4079:Caveolin
4002:JAK-STAT
3903:Paxillin
3894:Archived
3887:Paxillin
3867:18650496
3746:22362259
3339:37850994
3331:12234367
3302:35708933
3294:11779709
3249:11304546
3208:11134073
3159:26455236
3151:11146675
3116:11069756
2913:20139696
2842:Oncogene
2823:18172305
2773:21045234
2724:19540241
2675:10749567
2626:12228222
2585:10749882
2544:17785437
2495:21937583
2446:17462669
2408:16533505
2367:41193996
2155:26269466
2147:11911889
2063:10400685
2014:10840040
1913:July 13,
1848:–
1827:–
1779:pp125FAK
1761:PTP-PEST
1754:interact
1649:tyrosine
1617:vinculin
1529:vinculin
1485:vinculin
1469:integrin
1444:Function
1421:. Three
1391:vinculin
1387:pp125FAK
1356:cysteine
1295:Paxillin
1267:Wikidata
868:Sources:
301:12q24.23
3949:PDBe-KB
3939:UniProt
3928:PDBe-KB
3918:UniProt
3858:2522309
3824:9621077
3781:9603926
3738:9590268
3703:9488700
3668:9099734
3633:9054445
3598:8986614
3559:8810278
3524:8641358
3503:8609175
3494:2120789
3460:7657702
3451:2120552
3417:7529872
3374:7493940
3199:2150668
3081:8922390
3072:2133378
3032:7579684
2983:7525621
2948:8207093
2904:2852571
2864:9467941
2814:2767335
2764:3002839
2715:3427732
2535:2169049
2486:3246880
2359:2372136
2324:7615549
2283:2118142
2274:2116264
2231:9785458
2196:7534286
2106:9635426
2098:9699628
2022:9744939
1959:9497381
1850:Ensembl
1829:Ensembl
1767:tubulin
1603:, with
1561:proline
1515:to the
1411:proline
1399:leucine
1383:leucine
1368:tubulin
1299:protein
1001:UniProt
956:Ensembl
895:Species
874:QuickGO
768:cytosol
443:pattern
169:Aliases
4152:SH3BP2
4062:14-3-3
3944:Q8VI36
3923:P49023
3909:(MeSH)
3865:
3855:
3822:
3815:110419
3812:
3779:
3744:
3736:
3701:
3666:
3631:
3596:
3557:
3522:
3501:
3491:
3458:
3448:
3415:
3408:231937
3405:
3372:
3337:
3329:
3300:
3292:
3247:
3206:
3196:
3157:
3149:
3114:
3079:
3069:
3030:
3023:301225
3020:
2981:
2946:
2911:
2901:
2862:
2821:
2811:
2771:
2761:
2722:
2712:
2673:
2666:377478
2663:
2624:
2583:
2542:
2532:
2493:
2483:
2444:
2406:
2365:
2357:
2322:
2281:
2271:
2229:
2194:
2153:
2145:
2104:
2096:
2061:
2020:
2012:
1957:
1790:SORBS1
1756:with:
1589:serine
1569:ponsin
1509:Z-disc
1253:search
1251:PubMed
1034:Q8VI36
1015:P49023
911:Entrez
614:BioGPS
201:108295
193:602505
4139:TRAF6
4134:TRAF5
4129:TRAF4
4124:TRAF3
4119:TRAF2
4114:TRAF1
4099:MYD88
4072:YWHAZ
4067:YWHAE
4051:Other
4042:GRB10
3742:S2CID
3335:S2CID
3298:S2CID
3155:S2CID
2363:S2CID
2151:S2CID
2102:S2CID
2018:S2CID
1980:(PDF)
1796:PARVA
1434:talin
1297:is a
944:19303
904:Mouse
899:Human
870:Amigo
466:Mouse
459:Human
406:Start
341:Mouse
305:Start
238:Human
209:37697
4175:CHML
4157:LDB3
4147:BIN1
4109:TRAF
4104:SMAD
4037:GRB7
4032:GRB2
3937:for
3916:for
3863:PMID
3820:PMID
3777:PMID
3734:PMID
3699:PMID
3664:PMID
3629:PMID
3594:PMID
3555:PMID
3520:PMID
3499:PMID
3456:PMID
3413:PMID
3370:PMID
3327:PMID
3290:PMID
3245:PMID
3204:PMID
3147:PMID
3112:PMID
3077:PMID
3028:PMID
2979:PMID
2944:PMID
2909:PMID
2860:PMID
2819:PMID
2769:PMID
2720:PMID
2671:PMID
2622:PMID
2581:PMID
2540:PMID
2491:PMID
2442:PMID
2404:PMID
2355:PMID
2320:PMID
2279:PMID
2227:PMID
2192:PMID
2143:PMID
2094:PMID
2059:PMID
2010:PMID
1955:PMID
1915:2015
1721:and
1683:rac1
1479:and
1389:and
1377:The
1343:The
1306:gene
925:5829
449:Bgee
397:Band
358:Chr.
296:Band
255:Chr.
189:OMIM
146:4XH2
142:4XGZ
138:3RQG
134:3RQF
130:3RQE
126:1OW8
122:1OW7
118:1OW6
114:4EDN
110:3U3F
106:3PY7
102:3GM1
98:2VZI
94:2VZG
90:2VZD
86:2O9V
67:RCSB
64:PDBe
4170:CHM
4010:see
3935:PDB
3914:PDB
3853:PMC
3845:doi
3841:121
3810:PMC
3802:doi
3767:doi
3763:273
3724:doi
3720:160
3689:doi
3685:273
3654:doi
3650:272
3619:doi
3615:272
3584:hdl
3576:doi
3572:229
3545:doi
3541:271
3489:PMC
3481:doi
3477:133
3446:PMC
3438:doi
3434:130
3403:PMC
3395:doi
3360:doi
3356:270
3319:doi
3315:186
3280:doi
3235:doi
3231:276
3194:PMC
3186:doi
3182:151
3139:doi
3104:doi
3100:113
3067:PMC
3059:doi
3055:135
3018:PMC
3010:doi
2971:doi
2967:107
2936:doi
2932:107
2899:PMC
2891:doi
2850:doi
2809:PMC
2801:doi
2759:PMC
2751:doi
2710:PMC
2702:doi
2661:PMC
2653:doi
2649:105
2612:doi
2608:277
2571:doi
2567:275
2530:PMC
2522:doi
2481:PMC
2473:doi
2434:doi
2430:369
2394:doi
2390:293
2347:doi
2343:227
2310:doi
2306:270
2269:PMC
2261:doi
2257:111
2219:doi
2182:doi
2178:270
2133:doi
2129:513
2086:doi
2049:doi
2045:274
2002:hdl
1992:doi
1988:275
1945:doi
1941:273
1802:ILK
1798:and
1785:SRC
1773:VCL
1735:PXN
1613:FAK
1599:in
1593:FAK
1587:at
1585:FAK
1583:of
1567:of
1495:In
1490:Crk
1477:Src
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