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526:. By simulating compounds with FDA or similar regulatory approval, the authors found 4 interfacial molecules that could potentially disrupt the SARS-CoV-2 interface with ACE-2 receptors, suggesting that such small molecules could mitigate SARS-CoV-2 infection. The 4 candidate interfacial molecules included pemirolast,
708:
Abelson MB, Berdy GJ, Mundorf T, Amdahl LD, Graves AL (October 2002). "Pemirolast potassium 0.1% ophthalmic solution is an effective treatment for allergic conjunctivitis: a pooled analysis of two prospective, randomized, double-masked, placebo-controlled, phase III studies".
641:
522:
Pemirolast has appeared as a possible candidate for SARS-CoV-2 (COVID-19) spike protein disruption and interference. Such results were ascertained by molecular dynamics calculations executed on the
679:
Kawashima T, Iwamoto I, Nakagawa N, Tomioka H, Yoshida S (1994). "Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils".
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83:
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642:"Repurposing Therapeutics for COVID-19: Supercomputer-Based Docking to the SARS-CoV-2 Viral Spike Protein and Viral Spike Protein-Human ACE2 Interface"
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Kemp JP, Bernstein IL, Bierman CW, et al. (June 1992). "Pemirolast, a new oral nonbronchodilator drug for chronic asthma".
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Tinkelman DG, Berkowitz RB (February 1991). "A pilot study of pemirolast in patients with seasonal allergic rhinitis".
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583:"Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis"
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with pemirolast potassium may be more effective in alleviating symptoms than levocabastine alone.
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556:"Pemirolast ophthalmic (Alamast) Use During Pregnancy"
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1464:. You can help Knowledge (XXG) by
640:Smith, MD, Smith JC (April 2020).
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1444:
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883:Bromazine (bromodiphenhydramine)
443:CC1=CC=CN2C1=NC=C(C2=O)C3=NNN=N3
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1511:Drugs not assigned an ATC code
1139:Tripelennamine (pyribenzamine)
599:10.1002/14651858.CD009566.pub2
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1536:Respiratory system drug stubs
1013:Phenylpyridinylpropanamines:
936:Diphenylmethanolpiperidines
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681:Int. Arch. Allergy Immunol
587:Cochrane Database Syst Rev
362:Chemical and physical data
954:Diphenylmethylpiperazines
880:Diarylmethoxyalkylamines:
723:10.1089/10807680260362759
451:
431:
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28:
1456:article relating to the
1226:Hydroxyethylpromethazine
500:studying treatments for
1516:H1 receptor antagonists
1399:Mepyramine (pyrilamine)
1119:Mepyramine (pyrilamine)
771:Drug Information Portal
502:allergic conjunctivitis
767:"Pemirolast Potassium"
156:-pyridopyrimidin-4-one
711:J Ocul Pharmacol Ther
1158:Dibenzocycloheptenes
524:Summit supercomputer
480:mast cell stabilizer
1036:Dexchlorpheniramine
506:ophthalmic solution
504:have found that an
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1458:respiratory system
1026:Dexbrompheniramine
562:. 2 September 2020
528:isoniazid pyruvate
1531:Pyridopyrimidines
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1325:Phenylpiperazines
693:10.1159/000236662
469:
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422:Interactive image
331:CompTox Dashboard
152:-tetrazol-5-yl)-4
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16:Chemical compound
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1369:Chlorphenoxamine
1096:Ethylenediamines
1071:Phenyltoloxamine
1030:+pseudoephedrine
913:Diphenylpyraline
893:Chlorphenoxamine
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38:Clinical data
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1466:expanding it
1451:
1436:
1404:Promethazine
1394:Isothipendyl
1324:
1304:Phenindamine
1284:Latrepirdine
1273:trimipramine
1257:
1251:Promethazine
1241:Methdilazine
1231:Isothipendyl
1209:
1156:
1086:Triprolidine
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991:Etodroxizine
952:
941:Fexofenadine
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928:Orphenadrine
879:
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684:
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663:
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566:13 September
564:. Retrieved
559:
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459:
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153:
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105:Legal status
99:Legal status
18:
1379:Dimetindene
1309:Pimethixene
1294:Olopatadine
1289:Mebhydrolin
1269:mirtazapine
1246:Oxomemazine
1236:Mequitazine
1221:Fenethazine
1216:Alimemazine
1134:Thenalidine
1081:Quifenadine
1066:Dimetindene
1056:Acrivastine
1046:Pheniramine
996:Hydroxyzine
981:Cinnarizine
946:Terfenadine
857:Mizolastine
740:Ann Allergy
660:Ann Allergy
536:eriodictyol
508:containing
482:used as an
405: g·mol
132:Identifiers
44:Trade names
1521:Tetrazoles
1505:Categories
1374:Clemastine
1279:Epinastine
1203:Rupatadine
1198:Loratadine
1183:Deptropine
1149:Tricyclics
1104:Antazoline
964:Cetirizine
918:Doxylamine
898:Clemastine
852:Emedastine
842:Azelastine
837:Astemizole
542:References
472:Pemirolast
410:3D model (
398:Molar mass
280:2C09NV773M
251:ChemSpider
211:IUPHAR/BPS
175:69372-19-6
166:CAS Number
141:IUPAC name
23:Pemirolast
1333:trazodone
1299:Perlapine
1193:Ketotifen
1173:Azatadine
1006:Oxatomide
1001:Meclizine
986:Cyclizine
959:Buclizine
907:+naproxen
862:Talastine
847:Bilastine
608:2164/6048
560:Drugs.com
72:Routes of
64:Monograph
58:Drugs.com
1431:Medicine
1359:Bamipine
1061:Bamipine
923:Ebastine
731:12419098
646:Preprint
627:26028608
618:10616535
488:Alegysal
462:(verify)
231:DrugBank
84:ATC code
1526:Lactams
1389:Doxepin
1350:topical
1331:(e.g.,
1265:doxepin
1263:(e.g.,
1258:Others:
1165:(e.g.,
1053:Others:
752:1610024
701:8130655
672:1994787
648:: 1–28.
492:Alamast
478:) is a
403:228.215
368:Formula
240:DB00885
186:PubChem
48:Alamast
1417:Portal
1318:Others
750:
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699:
670:
625:
615:
534:, and
517:asthma
436:SMILES
311:ChEMBL
300:D07476
120:℞-only
118:
1460:is a
1452:This
412:JSmol
260:51990
200:57697
1462:stub
1454:drug
1348:For
748:PMID
727:PMID
697:PMID
668:PMID
623:PMID
591:2015
568:2020
490:and
291:KEGG
271:UNII
220:7329
91:none
54:AHFS
1352:use
813:R06
719:doi
689:doi
685:103
613:PMC
603:hdl
595:doi
476:INN
336:EPA
190:CID
1507::
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1271:,
1267:,
1214::
1161::
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769:.
744:68
742:.
725:.
715:18
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664:66
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611:.
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589:.
585:.
558:.
538:.
530:,
519:.
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376:10
114:US
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