244:
221:
118:
143:
495:
250:
149:
1381:, promoting both migration and invasion of macrophages and monocytes into glioblastomas in a dose-dependent manner. Clinically, periostin-associated gene signatures, which are predominated by secreted and matrix proteins, correspond to patient prognosis and malignancy. Given its features related to glioblastoma progression, periostin is a marker of
1360:
Periostin over-expression was reported in several types of cancer, most frequently in the environment of tumor cells. Recent evidence shows that periostin is a component of the extracellular matrix expressed by fibroblasts in normal tissues and stroma of primary tumor. The metastatic colony formation
1275:
While periostin plays a wide variety of roles in tissue development along with disease, its function in tissue remodeling as a response to injury is a common underlying role in these different mechanisms. Periostin is transiently upregulated during cell fate changes, whether they are related to
1376:
signaling. These M2 TAMs differentiate from monocytes once they enter the tumor tissue. Through this recruitment mechanism, periostin supports tumor progression, as M2 tumor-associated macrophages are tumor-supportive and immunosuppressive. In this environment, periostin functions as a
2886:
Baril P, Gangeswaran R, Mahon PC, Caulee K, Kocher HM, Harada T, Zhu M, Kalthoff H, Crnogorac-Jurcevic T, Lemoine NR (Mar 2007). "Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway".
1368:(grade IV gliomas) compared to the normal brain. In gliomas, periostin expression levels correlate directly with tumor grade and recurrence, and inversely with survival. It has been shown that glioma stem cells in glioblastomas secrete periostin, which recruits M2 tumor-associated
1361:
requires the induction of periostin in the foreign stroma by the infiltrating cancer cells. Periostin production is upregulated in lung fibroblasts by either TGF-β2 or TGF-β3, the latter being secreted by infiltrating cancer stem cells (in MMTV-PyMT mouse breast cancer model)
1280:
restructuring, tissue remodeling, and the epithelial-mesenchymal transition, all of which can be related to tissue healing, development, and disease. Thus, it functions as a mediator, balancing appropriate and inappropriate responses to tissue damage.
1328:γ2. Periostin is involved in wound healing, helping for the wound to heal faster than when periostin is not present in cells. This delay in wound closure is also associated with a delay in re-epithelialization and a reduction in the proliferation of
2802:
Försti A, Jin Q, Altieri A, Johansson R, Wagner K, Enquist K, Grzybowska E, Pamula J, Pekala W, Hallmans G, Lenner P, Hemminki K (Jan 2007). "Polymorphisms in the KDR and POSTN genes: association with breast cancer susceptibility and prognosis".
2686:
Chang Y, Lee TC, Li JC, Lai TL, Chua HH, Chen CL, Doong SL, Chou CK, Sheen TS, Tsai CH (Oct 2005). "Differential expression of osteoblast-specific factor 2 and polymeric immunoglobulin receptor genes in nasopharyngeal carcinoma".
3012:
Contié S, Voorzanger-Rousselot N, Litvin J, Bonnet N, Ferrari S, Clézardin P, Garnero P (Oct 2010). "Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice".
1332:. Periostin localizes to the extracellular compartment of cells during tissue remodeling associated with wound repair. It may also promote injury closure by facilitating the activation, differentiation, and contraction of
1310:
from valvular intestinal cells, endothelial cells, and macrophages. It is thought that periostin plays a role in cardiac valve complex degeneration by inducing both angiogenesis and matrix metalloproteinase production.
1892:
Gillan L, Matei D, Fishman DA, Gerbin CS, Karlan BY, Chang DD (Sep 2002). "Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility".
2840:
Grigoriadis A, Mackay A, Reis-Filho JS, Steele D, Iseli C, Stevenson BJ, Jongeneel CV, Valgeirsson H, Fenwick K, Iravani M, Leao M, Simpson AJ, Strausberg RL, Jat PS, Ashworth A, Neville AM, O'Hare MJ (2007).
1336:. However, the increase in periostin expression associated with tissue regeneration post-injury is transient, starting a few days post-injury, peaking after seven days post-injury, and decreasing afterwards.
1319:
As a matricellular protein, periostin is also important for tissue regeneration. In healthy human skin, periostin is expressed at basal levels and is expressed in the epidermis and hair follicles along with
2385:
Mikheev AM, Mikheeva SA, Trister AD, Tokita MJ, Emerson SN, Parada CA, Born DE, Carnemolla B, Frankel S, Kim DH, Oxford RG, Kosai Y, Tozer-Fink KR, Manning TC, Silber JR, Rostomily RC (Aug 2014).
257:
156:
2575:"Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression"
2227:
Corren J, Lemanske RF, Hanania NA, Korenblat PE, Parsey MV, Arron JR, Harris JM, Scheerens H, Wu LC, Su Z, Mosesova S, Eisner MD, Bohen SP, Matthews JG (Sep 2011).
1302:. While periostin usually is localized to the subendothelial layer in healthy heart valves, its levels are highly increased in infiltrated inflammatory cells and
803:
784:
79:
3050:
Kashyap MK, Marimuthu A, Peri S, Kumar GS, Jacob HK, Prasad TS, Mahmood R, Kumar KV, Kumar MV, Meltzer SJ, Montgomery EA, Kumar RV, Pandey A (2010).
2769:"Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation"
1306:
in angiogenic areas in atherosclerotic and rheumatic valvular heart disease in humans. Periostin has also been shown to increase the secretion of
2653:"Periostin is down-regulated in high grade human bladder cancers and suppresses in vitro cell invasiveness and in vivo metastasis of cancer cells"
3110:
2485:"Human periostin gene expression in normal tissues, tumors and melanoma: evidences for periostin production by both stromal and melanoma cells"
2128:"Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents"
3105:
1808:
1790:
2843:"Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data"
2540:"Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas"
243:
1103:
1235:
1110:
220:
1875:
2556:
2539:
2126:
Hakuno D, Kimura N, Yoshioka M, Mukai M, Kimura T, Okada Y, Yozu R, Shukunami C, Hiraki Y, Kudo A, Ogawa S, Fukuda K (Jul 2010).
3120:
3115:
1777:
1756:
1385:
malignancy as well as recurrence of tumors, making it a possible target for therapy that continues to be studied and explored.
1242:
in the developing heart. This protein shares a homology with fasciclin I, a secreted cell adhesion molecule found in insects.
1828:"Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I"
142:
117:
1773:
1226:
Periostin is a secreted extracellular matrix protein that was originally identified in cells from the mesenchymal lineage (
1752:
59:
2436:"Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth"
2270:"Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases"
2178:
Braun N, Sen K, Alscher MD, Fritz P, Kimmel M, Morelle J, Goffin E, Jörres A, Wüthrich RP, Cohen CD, Segerer S (2013).
256:
155:
2924:
Siriwardena BS, Kudo Y, Ogawa I, Kitagawa M, Kitajima S, Hatano H, Tilakaratne WM, Miyauchi M, Takata T (Nov 2006).
2618:"Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway"
2434:
Zhou W, Ke SQ, Huang Z, Flavahan W, Fang X, Paul J, Wu L, Sloan AE, McLendon RE, Li X, Rich JN, Bao S (Feb 2015).
1922:"Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells"
249:
148:
2726:"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry"
1250:
1307:
848:
67:
1268:
In humans and mice, periostin undergoes alternative splicing in its C-terminal region, resulting in specific
829:
1299:
131:
1649:
2077:
Conway SJ, Izuhara K, Kudo Y, Litvin J, Markwald R, Ouyang G, Arron JR, Holweg CT, Kudo A (Apr 2014).
1466:
2330:
1977:
1277:
46:
2573:
Shao R, Bao S, Bai X, Blanchette C, Anderson RM, Dang T, Gishizky ML, Marks JR, Wang XF (May 2004).
1373:
2317:
Malanchi I, Santamaria-Martínez A, Susanto E, Peng H, Lehr HA, Delaloye JF, Huelsken J (Jan 2012).
1086:
1072:
1068:
1064:
1060:
1037:
1033:
1023:
1019:
1015:
1011:
1007:
987:
977:
973:
965:
961:
946:
938:
928:
924:
920:
916:
912:
1045:
3038:
2912:
2828:
2712:
2364:
2299:
91:
2616:
Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, Shao R, Anderson RM, Rich JN, Wang XF (Apr 2004).
1076:
1041:
969:
942:
1272:
that can be observed in a broad range of cancers such as pancreatic, colon, and breast cancer.
3083:
3030:
3000:
2955:
2904:
2874:
2820:
2790:
2755:
2704:
2674:
2639:
2604:
2561:
2516:
2465:
2416:
2356:
2291:
2250:
2209:
2157:
2108:
2054:
2025:"Periostin expression and epithelial-mesenchymal transition in cancer: a review and an update"
2005:
1943:
1902:
1857:
1705:
1692:
494:
39:
2926:"Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer"
2180:"Periostin: a matricellular protein involved in peritoneal injury during peritoneal dialysis"
1595:
3073:
3063:
3022:
2990:
2980:
2945:
2937:
2896:
2864:
2854:
2812:
2780:
2745:
2737:
2696:
2664:
2629:
2594:
2586:
2551:
2506:
2496:
2455:
2447:
2406:
2398:
2346:
2338:
2281:
2240:
2199:
2191:
2147:
2139:
2098:
2090:
2044:
2036:
1995:
1985:
1933:
1847:
1839:
1582:
1517:
1479:
1443:
1438:
336:
267:
211:
166:
1636:
1623:
1543:
87:
2538:
Sasaki H, Dai M, Auclair D, Fukai I, Kiriyama M, Yamakawa Y, Fujii Y, Chen LB (Aug 2001).
1718:
1679:
1613:
1530:
1504:
1491:
1423:
1408:
1378:
311:
1664:
2334:
1981:
3078:
3051:
2995:
2968:
2950:
2925:
2869:
2842:
2750:
2725:
2511:
2484:
2460:
2435:
2411:
2387:"Periostin is a novel therapeutic target that predicts and regulates glioma malignancy"
2386:
2319:"Interactions between cancer stem cells and their niche govern metastatic colonization"
2204:
2179:
2152:
2127:
2103:
2078:
2049:
2024:
2000:
1966:"Periostin shows increased evolutionary plasticity in its alternatively spliced region"
1965:
1852:
1827:
1303:
1295:
1204:
1193:
1189:
2634:
2617:
2599:
2574:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
643:
638:
633:
628:
623:
607:
602:
597:
592:
587:
582:
577:
572:
556:
551:
546:
541:
536:
3099:
1428:
1365:
1329:
1200:
523:
3042:
2916:
2832:
2716:
2590:
2303:
71:
2368:
1654:
1413:
1349:
1258:
329:
108:
2969:"Expression of periostin and its clinicopathological relevance in gastric cancer"
95:
1813:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1795:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1369:
1321:
3052:"Overexpression of periostin and lumican in esophageal squamous cell carcinoma"
2268:
Contié S, Voorzanger-Rousselot N, Litvin J, Clézardin P, Garnero P (Jan 2011).
412:
3026:
2816:
2094:
2040:
1333:
1262:
1239:
1231:
1227:
1215:
1208:
228:
125:
75:
2985:
2724:
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006).
2402:
1990:
748:
472:
350:
295:
282:
194:
181:
83:
3087:
3068:
3034:
3004:
2959:
2941:
2908:
2900:
2878:
2824:
2794:
2785:
2768:
2759:
2708:
2678:
2643:
2608:
2565:
2520:
2501:
2469:
2420:
2360:
2318:
2295:
2254:
2213:
2195:
2161:
2112:
2058:
2009:
1947:
1938:
1921:
1920:
Coutu DL, Wu JH, Monette A, Rivard GE, Blostein MD, Galipeau J (Jun 2008).
1906:
2245:
2228:
1861:
1150:
1145:
1669:
1269:
1246:
1196:
1134:
893:
874:
2557:
10.1002/1097-0142(20010815)92:4<843::AID-CNCR1391>3.0.CO;2-P
2342:
2483:
Tilman G, Mattiussi M, Brasseur F, van Baren N, Decottignies A (2007).
1325:
1178:
860:
815:
2741:
2700:
2669:
2652:
2351:
2286:
2269:
2079:"The role of periostin in tissue remodeling across health and disease"
1843:
2651:
Kim CJ, Yoshioka N, Tambe Y, Kushima R, Okada Y, Inoue H (Oct 2005).
2143:
1569:
1382:
1345:
1257:
signaling pathways. This leads to increased cell survival, invasion,
1118:
770:
2859:
2451:
1276:
alterations in physiology or to pathological changes. It influences
1608:
624:
negative regulation of substrate adhesion-dependent cell spreading
1348:, a fact that is exploited by the experimental asthma medication
733:
729:
1556:
1453:
1254:
1185:
503:
63:
1959:
1957:
689:
cellular response to transforming growth factor beta stimulus
1876:"Entrez Gene: POSTN periostin, osteoblast specific factor"
1230:, osteoblast-derived cells, the periodontal ligament, and
319:
1294:
Periostin plays a critical role in the development of
669:
cellular response to fibroblast growth factor stimulus
1826:
Takeshita S, Kikuno R, Tezuka K, Amann E (Aug 1993).
1391:: Periostin expression in various cancer cell lines.
1364:
Periostin has been shown to be highly upregulated in
484:
1372:from peripheral blood to the tumor environment via
1059:
1006:
960:
911:
684:
positive regulation of smooth muscle cell migration
1769:
1767:
1765:
1748:
1746:
1744:
2380:
2378:
266:
165:
2072:
2070:
2068:
2173:
2171:
16:Protein-coding gene in the species Homo sapiens
2229:"Lebrikizumab treatment in adults with asthma"
1887:
1885:
1774:GRCm38: Ensembl release 89: ENSMUSG00000027750
654:regulation of systemic arterial blood pressure
1265:, and the epithelial-mesenchymal transition.
8:
2967:Li JS, Sun GW, Wei XY, Tang WH (Oct 2007).
1753:GRCh38: Ensembl release 89: ENSG00000133110
694:negative regulation of cell-matrix adhesion
552:extracellular matrix structural constituent
1238:in cancer and with the differentiation of
1056:
1003:
957:
908:
744:
709:cellular response to tumor necrosis factor
519:
307:
206:
103:
3077:
3067:
2994:
2984:
2949:
2868:
2858:
2784:
2749:
2668:
2633:
2598:
2555:
2510:
2500:
2459:
2410:
2350:
2285:
2244:
2203:
2151:
2102:
2048:
1999:
1989:
1937:
1851:
1393:
608:collagen-containing extracellular matrix
1740:
1188:. Periostin functions as a ligand for
1964:Hoersch S, Andrade-Navarro MA (2010).
20:
2132:The Journal of Clinical Investigation
629:regulation of Notch signaling pathway
271:
232:
227:
170:
129:
124:
7:
2805:Breast Cancer Research and Treatment
2083:Cellular and Molecular Life Sciences
1245:In many cancers, periostin binds to
2773:The Journal of Biological Chemistry
2233:The New England Journal of Medicine
1926:The Journal of Biological Chemistry
1234:). It has been associated with the
1315:In tissue regeneration and healing
884:
865:
839:
820:
794:
775:
489:
407:
345:
324:
14:
2973:World Journal of Gastroenterology
2184:Peritoneal Dialysis International
1236:epithelial-mesenchymal transition
1181:that in humans is encoded by the
719:extracellular matrix organization
1249:on cancer cells, activating the
1175:osteoblast-specific factor OSF-2
493:
255:
248:
242:
219:
154:
147:
141:
116:
2657:International Journal of Cancer
2591:10.1128/MCB.24.9.3992-4003.2004
2274:International Journal of Cancer
639:response to mechanical stimulus
50:, OSF-2, OSF2, PDLPN, periostin
3015:Calcified Tissue International
2579:Molecular and Cellular Biology
714:cellular response to vitamin K
557:cell adhesion molecule binding
504:More reference expression data
473:More reference expression data
1:
3111:Extracellular matrix proteins
2635:10.1016/S1535-6108(04)00081-9
1344:Periostin is associated with
443:tunica media of zone of aorta
240:
139:
3106:Genes on human chromosome 13
2730:Journal of Proteome Research
2023:Morra L, Moch H (Nov 2011).
1732:(cDNA POSTN/cDNA ACTB) × 10
1218:vitamin K dependent factor.
699:response to muscle activity
659:skeletal system development
644:neuron projection extension
3137:
2767:Yan W, Shao R (Jul 2006).
3027:10.1007/s00223-010-9391-y
2930:British Journal of Cancer
2817:10.1007/s10549-006-9265-1
2095:10.1007/s00018-013-1494-y
2041:10.1007/s00428-011-1151-5
1809:"Mouse PubMed Reference:"
1791:"Human PubMed Reference:"
1290:In valvular heart disease
1149:
1144:
1140:
1133:
1117:
1098:
1083:
1030:
999:
984:
935:
904:
891:
887:
872:
868:
859:
846:
842:
827:
823:
814:
801:
797:
782:
778:
769:
754:
747:
743:
727:
522:
518:
501:
492:
483:
470:
419:
410:
393:Descending thoracic aorta
377:mucosa of paranasal sinus
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
2986:10.3748/wjg.v13.i39.5261
1970:BMC Evolutionary Biology
1308:matrix metalloproteinase
1991:10.1186/1471-2148-10-30
1832:The Biochemical Journal
1471:Ovarian teratocarcinoma
1104:Chr 13: 37.56 – 37.6 Mb
459:internal carotid artery
451:external carotid artery
3121:Cell adhesion proteins
3116:Matricellular proteins
3069:10.3390/cancers2010133
2942:10.1038/sj.bjc.6603431
2901:10.1038/sj.onc.1210009
2847:Breast Cancer Research
2786:10.1074/jbc.M601856200
2502:10.1186/1476-4598-6-80
2196:10.3747/pdi.2010.00259
1939:10.1074/jbc.M708029200
1300:valvular heart disease
1111:Chr 3: 54.27 – 54.3 Mb
598:neuromuscular junction
423:atrioventricular valve
2403:10.1093/neuonc/nou161
2246:10.1056/NEJMoa1106469
1285:Clinical significance
664:response to estradiol
132:Chromosome 13 (human)
1600:Pancreatic carcinoma
1587:Pancreatic carcinoma
1535:Renal cell carcinoma
1522:Renal cell carcinoma
1298:and in degenerative
1278:extracellular matrix
593:extracellular matrix
573:extracellular region
447:skin of external ear
234:Chromosome 3 (mouse)
2440:Nature Cell Biology
2343:10.1038/nature10694
2335:2012Natur.481...85M
1982:2010BMCEE..10...30H
634:response to hypoxia
603:extracellular space
583:trans-Golgi network
1932:(26): 17991–8001.
849:ENSMUSG00000027750
679:tissue development
617:Biological process
566:Cellular component
530:Molecular function
2742:10.1021/pr0502065
2701:10.1002/hed.20253
2670:10.1002/ijc.21120
2287:10.1002/ijc.25591
1844:10.1042/bj2940271
1730:
1729:
1628:Bladder carcinoma
1548:Colorectal cancer
1160:
1159:
1156:
1155:
1129:
1128:
1094:
1093:
1053:
1052:
995:
994:
954:
953:
900:
899:
881:
880:
855:
854:
836:
835:
810:
809:
791:
790:
739:
738:
674:bone regeneration
537:metal ion binding
514:
513:
510:
509:
479:
478:
466:
465:
404:
403:
361:periodontal fiber
302:
301:
201:
200:
96:POSTN - orthologs
3128:
3091:
3081:
3071:
3046:
3008:
2998:
2988:
2963:
2953:
2936:(10): 1396–403.
2920:
2882:
2872:
2862:
2836:
2798:
2788:
2763:
2753:
2720:
2682:
2672:
2647:
2637:
2612:
2602:
2585:(9): 3992–4003.
2569:
2559:
2525:
2524:
2514:
2504:
2489:Molecular Cancer
2480:
2474:
2473:
2463:
2431:
2425:
2424:
2414:
2382:
2373:
2372:
2354:
2314:
2308:
2307:
2289:
2265:
2259:
2258:
2248:
2224:
2218:
2217:
2207:
2175:
2166:
2165:
2155:
2144:10.1172/JCI40973
2123:
2117:
2116:
2106:
2074:
2063:
2062:
2052:
2020:
2014:
2013:
2003:
1993:
1961:
1952:
1951:
1941:
1917:
1911:
1910:
1889:
1880:
1879:
1872:
1866:
1865:
1855:
1823:
1817:
1816:
1805:
1799:
1798:
1787:
1781:
1771:
1760:
1750:
1444:Rhabdomyosarcoma
1394:
1142:
1141:
1113:
1106:
1089:
1057:
1048:
1004:
1000:RefSeq (protein)
990:
958:
949:
909:
885:
866:
840:
821:
795:
776:
745:
520:
506:
497:
490:
475:
435:efferent ductule
415:
413:Top expressed in
408:
397:lactiferous duct
373:cartilage tissue
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
49:
42:
21:
3136:
3135:
3131:
3130:
3129:
3127:
3126:
3125:
3096:
3095:
3094:
3049:
3011:
2966:
2923:
2895:(14): 2082–94.
2885:
2860:10.1186/bcr1604
2839:
2801:
2779:(28): 19700–8.
2766:
2723:
2689:Head & Neck
2685:
2650:
2615:
2572:
2537:
2533:
2531:Further reading
2528:
2482:
2481:
2477:
2452:10.1038/ncb3090
2433:
2432:
2428:
2384:
2383:
2376:
2316:
2315:
2311:
2267:
2266:
2262:
2239:(12): 1088–98.
2226:
2225:
2221:
2177:
2176:
2169:
2138:(7): 2292–306.
2125:
2124:
2120:
2076:
2075:
2066:
2029:Virchows Archiv
2022:
2021:
2017:
1963:
1962:
1955:
1919:
1918:
1914:
1901:(18): 5358–64.
1895:Cancer Research
1891:
1890:
1883:
1874:
1873:
1869:
1825:
1824:
1820:
1807:
1806:
1802:
1789:
1788:
1784:
1772:
1763:
1751:
1742:
1738:
1614:Hepatocarcinoma
1458:Cervical cancer
1379:chemoattractant
1358:
1342:
1317:
1292:
1287:
1224:
1214:Periostin is a
1151:View/Edit Mouse
1146:View/Edit Human
1109:
1102:
1099:Location (UCSC)
1085:
1079:
1075:
1071:
1067:
1063:
1044:
1040:
1036:
1032:
1026:
1022:
1018:
1014:
1010:
986:
980:
976:
972:
968:
964:
945:
941:
937:
931:
927:
923:
919:
915:
830:ENSG00000133110
723:
612:
588:Golgi apparatus
561:
547:protein binding
542:heparin binding
502:
471:
462:
457:
453:
449:
445:
441:
437:
433:
429:
425:
411:
400:
395:
391:
387:
383:
379:
375:
371:
367:
365:visceral pleura
363:
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
17:
12:
11:
5:
3134:
3132:
3124:
3123:
3118:
3113:
3108:
3098:
3097:
3093:
3092:
3047:
3009:
2979:(39): 5261–6.
2964:
2921:
2883:
2837:
2799:
2764:
2736:(6): 2070–80.
2721:
2695:(10): 873–82.
2683:
2648:
2613:
2570:
2534:
2532:
2529:
2527:
2526:
2475:
2426:
2391:Neuro-Oncology
2374:
2329:(7379): 85–9.
2309:
2260:
2219:
2167:
2118:
2089:(7): 1279–88.
2064:
2015:
1953:
1912:
1881:
1867:
1818:
1800:
1782:
1761:
1739:
1737:
1734:
1728:
1727:
1724:
1721:
1715:
1714:
1711:
1708:
1702:
1701:
1698:
1695:
1689:
1688:
1685:
1682:
1676:
1675:
1672:
1667:
1661:
1660:
1657:
1652:
1646:
1645:
1642:
1641:Stomach cancer
1639:
1633:
1632:
1629:
1626:
1620:
1619:
1616:
1611:
1605:
1604:
1601:
1598:
1592:
1591:
1588:
1585:
1579:
1578:
1575:
1572:
1566:
1565:
1562:
1559:
1553:
1552:
1549:
1546:
1540:
1539:
1536:
1533:
1527:
1526:
1523:
1520:
1514:
1513:
1510:
1507:
1501:
1500:
1497:
1494:
1488:
1487:
1485:
1482:
1476:
1475:
1472:
1469:
1463:
1462:
1459:
1456:
1450:
1449:
1446:
1441:
1435:
1434:
1431:
1426:
1420:
1419:
1416:
1411:
1405:
1404:
1401:
1398:
1357:
1354:
1341:
1338:
1316:
1313:
1304:myofibroblasts
1296:cardiac valves
1291:
1288:
1286:
1283:
1223:
1220:
1194:alpha-V/beta-5
1190:alpha-V/beta-3
1158:
1157:
1154:
1153:
1148:
1138:
1137:
1131:
1130:
1127:
1126:
1124:
1122:
1115:
1114:
1107:
1100:
1096:
1095:
1092:
1091:
1081:
1080:
1054:
1051:
1050:
1028:
1027:
1001:
997:
996:
993:
992:
982:
981:
955:
952:
951:
933:
932:
906:
902:
901:
898:
897:
889:
888:
882:
879:
878:
870:
869:
863:
857:
856:
853:
852:
844:
843:
837:
834:
833:
825:
824:
818:
812:
811:
808:
807:
799:
798:
792:
789:
788:
780:
779:
773:
767:
766:
761:
756:
752:
751:
741:
740:
737:
736:
725:
724:
722:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
620:
618:
614:
613:
611:
610:
605:
600:
595:
590:
585:
580:
575:
569:
567:
563:
562:
560:
559:
554:
549:
544:
539:
533:
531:
527:
526:
516:
515:
512:
511:
508:
507:
499:
498:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
231:
225:
224:
216:
215:
203:
202:
199:
198:
190:
186:
185:
177:
174:
169:
163:
162:
153:
146:
140:
136:
135:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
3133:
3122:
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3103:
3101:
3089:
3085:
3080:
3075:
3070:
3065:
3062:(1): 133–42.
3061:
3057:
3053:
3048:
3044:
3040:
3036:
3032:
3028:
3024:
3021:(4): 341–50.
3020:
3016:
3010:
3006:
3002:
2997:
2992:
2987:
2982:
2978:
2974:
2970:
2965:
2961:
2957:
2952:
2947:
2943:
2939:
2935:
2931:
2927:
2922:
2918:
2914:
2910:
2906:
2902:
2898:
2894:
2890:
2884:
2880:
2876:
2871:
2866:
2861:
2856:
2852:
2848:
2844:
2838:
2834:
2830:
2826:
2822:
2818:
2814:
2810:
2806:
2800:
2796:
2792:
2787:
2782:
2778:
2774:
2770:
2765:
2761:
2757:
2752:
2747:
2743:
2739:
2735:
2731:
2727:
2722:
2718:
2714:
2710:
2706:
2702:
2698:
2694:
2690:
2684:
2680:
2676:
2671:
2666:
2662:
2658:
2654:
2649:
2645:
2641:
2636:
2631:
2628:(4): 329–39.
2627:
2623:
2619:
2614:
2610:
2606:
2601:
2596:
2592:
2588:
2584:
2580:
2576:
2571:
2567:
2563:
2558:
2553:
2549:
2545:
2541:
2536:
2535:
2530:
2522:
2518:
2513:
2508:
2503:
2498:
2494:
2490:
2486:
2479:
2476:
2471:
2467:
2462:
2457:
2453:
2449:
2446:(2): 170–82.
2445:
2441:
2437:
2430:
2427:
2422:
2418:
2413:
2408:
2404:
2400:
2397:(3): 372–82.
2396:
2392:
2388:
2381:
2379:
2375:
2370:
2366:
2362:
2358:
2353:
2348:
2344:
2340:
2336:
2332:
2328:
2324:
2320:
2313:
2310:
2305:
2301:
2297:
2293:
2288:
2283:
2280:(2): 352–60.
2279:
2275:
2271:
2264:
2261:
2256:
2252:
2247:
2242:
2238:
2234:
2230:
2223:
2220:
2215:
2211:
2206:
2201:
2197:
2193:
2190:(5): 515–28.
2189:
2185:
2181:
2174:
2172:
2168:
2163:
2159:
2154:
2149:
2145:
2141:
2137:
2133:
2129:
2122:
2119:
2114:
2110:
2105:
2100:
2096:
2092:
2088:
2084:
2080:
2073:
2071:
2069:
2065:
2060:
2056:
2051:
2046:
2042:
2038:
2035:(5): 465–75.
2034:
2030:
2026:
2019:
2016:
2011:
2007:
2002:
1997:
1992:
1987:
1983:
1979:
1975:
1971:
1967:
1960:
1958:
1954:
1949:
1945:
1940:
1935:
1931:
1927:
1923:
1916:
1913:
1908:
1904:
1900:
1896:
1888:
1886:
1882:
1877:
1871:
1868:
1863:
1859:
1854:
1849:
1845:
1841:
1837:
1833:
1829:
1822:
1819:
1814:
1810:
1804:
1801:
1796:
1792:
1786:
1783:
1779:
1775:
1770:
1768:
1766:
1762:
1758:
1754:
1749:
1747:
1745:
1741:
1735:
1733:
1725:
1722:
1720:
1717:
1716:
1712:
1709:
1707:
1704:
1703:
1699:
1696:
1694:
1691:
1690:
1686:
1683:
1681:
1678:
1677:
1673:
1671:
1668:
1666:
1663:
1662:
1658:
1656:
1653:
1651:
1648:
1647:
1643:
1640:
1638:
1635:
1634:
1630:
1627:
1625:
1622:
1621:
1617:
1615:
1612:
1610:
1607:
1606:
1602:
1599:
1597:
1594:
1593:
1589:
1586:
1584:
1581:
1580:
1576:
1574:Breast Cancer
1573:
1571:
1568:
1567:
1563:
1561:Breast Cancer
1560:
1558:
1555:
1554:
1550:
1547:
1545:
1542:
1541:
1537:
1534:
1532:
1529:
1528:
1524:
1521:
1519:
1516:
1515:
1511:
1508:
1506:
1503:
1502:
1498:
1495:
1493:
1490:
1489:
1486:
1483:
1481:
1478:
1477:
1473:
1470:
1468:
1465:
1464:
1460:
1457:
1455:
1452:
1451:
1447:
1445:
1442:
1440:
1437:
1436:
1432:
1430:
1429:Ewing sarcoma
1427:
1425:
1422:
1421:
1417:
1415:
1412:
1410:
1407:
1406:
1402:
1399:
1396:
1395:
1392:
1390:
1386:
1384:
1380:
1375:
1374:αvβ3 integrin
1371:
1367:
1366:glioblastomas
1362:
1355:
1353:
1351:
1347:
1339:
1337:
1335:
1331:
1330:keratinocytes
1327:
1323:
1314:
1312:
1309:
1305:
1301:
1297:
1289:
1284:
1282:
1279:
1273:
1271:
1266:
1264:
1260:
1256:
1252:
1248:
1243:
1241:
1237:
1233:
1229:
1221:
1219:
1217:
1212:
1210:
1206:
1202:
1198:
1195:
1191:
1187:
1184:
1180:
1176:
1172:
1168:
1164:
1152:
1147:
1143:
1139:
1136:
1132:
1125:
1123:
1120:
1116:
1112:
1108:
1105:
1101:
1097:
1090:
1088:
1082:
1078:
1074:
1070:
1066:
1062:
1058:
1055:
1049:
1047:
1043:
1039:
1035:
1029:
1025:
1021:
1017:
1013:
1009:
1005:
1002:
998:
991:
989:
983:
979:
975:
971:
967:
963:
959:
956:
950:
948:
944:
940:
934:
930:
926:
922:
918:
914:
910:
907:
905:RefSeq (mRNA)
903:
896:
895:
890:
886:
883:
877:
876:
871:
867:
864:
862:
858:
851:
850:
845:
841:
838:
832:
831:
826:
822:
819:
817:
813:
806:
805:
800:
796:
793:
787:
786:
781:
777:
774:
772:
768:
765:
762:
760:
757:
753:
750:
746:
742:
735:
731:
726:
720:
717:
715:
712:
710:
707:
705:
704:cell adhesion
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
649:wound healing
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
621:
619:
616:
615:
609:
606:
604:
601:
599:
596:
594:
591:
589:
586:
584:
581:
579:
576:
574:
571:
570:
568:
565:
564:
558:
555:
553:
550:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
427:body of femur
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
381:skin of thigh
380:
376:
372:
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
3059:
3055:
3018:
3014:
2976:
2972:
2933:
2929:
2892:
2888:
2850:
2846:
2811:(1): 83–93.
2808:
2804:
2776:
2772:
2733:
2729:
2692:
2688:
2660:
2656:
2625:
2621:
2582:
2578:
2550:(4): 843–8.
2547:
2543:
2492:
2488:
2478:
2443:
2439:
2429:
2394:
2390:
2326:
2322:
2312:
2277:
2273:
2263:
2236:
2232:
2222:
2187:
2183:
2135:
2131:
2121:
2086:
2082:
2032:
2028:
2018:
1973:
1969:
1929:
1925:
1915:
1898:
1894:
1870:
1838:(1): 271–8.
1835:
1831:
1821:
1812:
1803:
1794:
1785:
1731:
1655:Glioblastoma
1414:Osteosarcoma
1388:
1387:
1363:
1359:
1350:lebrikizumab
1343:
1318:
1293:
1274:
1267:
1259:angiogenesis
1255:FAK-mediated
1244:
1225:
1213:
1182:
1174:
1170:
1166:
1162:
1161:
1087:NP_001355607
1084:
1073:NP_001300828
1069:NP_001300827
1065:NP_001185695
1061:NP_001185694
1038:NP_001317446
1034:NP_001273596
1031:
1024:NP_001273595
1020:NP_001273594
1016:NP_001129408
1012:NP_001129407
1008:NP_001129406
988:NM_001368678
985:
978:NM_001313899
974:NM_001313898
966:NM_001198766
962:NM_001198765
947:NM_001330517
939:NM_001286667
936:
929:NM_001286666
925:NM_001286665
921:NM_001135936
917:NM_001135935
913:NM_001135934
892:
873:
847:
828:
802:
783:
763:
758:
335:
328:
55:External IDs
18:
2663:(1): 51–8.
2622:Cancer Cell
1403:POSTN/ACTB
1370:macrophages
1334:fibroblasts
1322:fibronectin
1228:osteoblasts
1199:to support
1046:NP_006466.2
455:human fetus
389:skin of arm
369:skin of hip
294:54,298,458
281:54,268,530
193:37,598,844
180:37,562,583
33:Identifiers
3100:Categories
2853:(5): R56.
2495:(80): 80.
2352:2297/35864
1780:, May 2017
1759:, May 2017
1736:References
1538:0.08±0.01
1263:metastasis
1240:mesenchyme
1232:periosteum
1216:gla domain
1209:epithelial
439:belly cord
339:(ortholog)
273:3|3 C
76:HomoloGene
1976:(1): 30.
1687:0.5±0.03
1618:0.3±0.07
1397:Cell line
1356:In cancer
1340:In asthma
1247:integrins
1205:migration
1197:integrins
1163:Periostin
1077:NP_056599
1042:NP_006466
970:NM_015784
943:NM_006475
749:Orthologs
578:cytoplasm
84:GeneCards
3088:24281036
3043:22592909
3035:20567965
3005:17876898
2960:17060937
2917:25177405
2909:17043657
2889:Oncogene
2879:17014703
2833:22086203
2825:16807673
2795:16702213
2760:16335952
2717:25139450
2709:16136586
2679:15880581
2644:15093540
2609:15082792
2566:11550156
2521:18086302
2470:25580734
2421:25140038
2361:22158103
2304:37866040
2296:20715172
2255:21812663
2214:23378472
2162:20551517
2113:24146092
2059:21997759
2010:20109226
1948:18450759
1907:12235007
1776:–
1755:–
1726:4.7±1.2
1723:Melanoma
1713:4.2±0.4
1710:Melanoma
1706:LB2201-3
1700:3.4±0.3
1697:Melanoma
1693:LB2586-7
1684:Melanoma
1674:2.3±0.7
1670:Melanoma
1631:1748±74
1577:3693±86
1525:0.8±0.2
1512:0.6±0.2
1499:3.4±0.2
1474:1.4±0.1
1461:3.0±0.4
1448:0.1±0.1
1418:3.5±1.7
1270:isoforms
1251:Akt/PKB-
1222:Function
1201:adhesion
1135:Wikidata
728:Sources:
3079:3827595
3056:Cancers
2996:4171309
2951:2360586
2870:1779497
2751:1850943
2512:2222651
2461:4312504
2412:4483094
2369:2128276
2331:Bibcode
2205:3797670
2153:2898587
2104:3949008
2050:3205268
2001:2824660
1978:Bibcode
1862:8363580
1853:1134594
1834:. 294.
1778:Ensembl
1757:Ensembl
1596:Capan-1
1326:laminin
1211:cells.
1179:protein
1177:) is a
861:UniProt
816:Ensembl
755:Species
734:QuickGO
385:pylorus
314:pattern
172:13q13.3
72:1926321
40:Aliases
3086:
3076:
3041:
3033:
3003:
2993:
2958:
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2915:
2907:
2877:
2867:
2831:
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2707:
2677:
2642:
2607:
2600:387763
2597:
2564:
2544:Cancer
2519:
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2419:
2409:
2367:
2359:
2323:Nature
2302:
2294:
2253:
2212:
2202:
2160:
2150:
2111:
2101:
2057:
2047:
2008:
1998:
1946:
1905:
1860:
1850:
1583:Panc-1
1570:Hs578T
1518:LB1047
1480:LB37-1
1439:LB23-1
1400:Origin
1383:glioma
1346:asthma
1121:search
1119:PubMed
894:Q62009
875:Q15063
771:Entrez
485:BioGPS
431:dermis
64:608777
3039:S2CID
2913:S2CID
2829:S2CID
2713:S2CID
2365:S2CID
2300:S2CID
1659:45±4
1637:MZGC3
1624:LB831
1609:Huh-7
1544:LB108
1484:NSCLC
1389:Table
1183:POSTN
1173:, or
1167:POSTN
804:50706
785:10631
764:Mouse
759:Human
730:Amigo
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
88:POSTN
47:POSTN
24:POSTN
3084:PMID
3031:PMID
3001:PMID
2956:PMID
2905:PMID
2875:PMID
2821:PMID
2791:PMID
2756:PMID
2705:PMID
2675:PMID
2640:PMID
2605:PMID
2562:PMID
2517:PMID
2466:PMID
2417:PMID
2357:PMID
2292:PMID
2251:PMID
2210:PMID
2158:PMID
2109:PMID
2055:PMID
2006:PMID
1944:PMID
1903:PMID
1858:PMID
1719:A375
1680:LB39
1650:A172
1557:MCF7
1531:BB64
1509:SCLC
1505:LB92
1496:SCLC
1492:LB85
1467:PA-1
1454:HeLa
1424:LB96
1409:U2OS
1324:and
1253:and
1203:and
1192:and
1186:gene
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
80:4730
60:OMIM
3074:PMC
3064:doi
3023:doi
2991:PMC
2981:doi
2946:PMC
2938:doi
2897:doi
2865:PMC
2855:doi
2813:doi
2809:101
2781:doi
2777:281
2746:PMC
2738:doi
2697:doi
2665:doi
2661:117
2630:doi
2595:PMC
2587:doi
2552:doi
2507:PMC
2497:doi
2456:PMC
2448:doi
2407:PMC
2399:doi
2347:hdl
2339:doi
2327:481
2282:doi
2278:128
2241:doi
2237:365
2200:PMC
2192:doi
2148:PMC
2140:doi
2136:120
2099:PMC
2091:doi
2045:PMC
2037:doi
2033:459
1996:PMC
1986:doi
1934:doi
1930:283
1848:PMC
1840:doi
1836:294
1665:MZ2
1207:of
290:End
189:End
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