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to expand. This was unusual, but since at that time chromosomes were not considered part of the cancer-causing puzzle, he could have disregarded the anomaly. Instead, he decided to investigate (he said later, "I didn’t know anything about chromosomes, but it seemed a shame to throw this away.")
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studying radiation and bone marrow transplantation and then returned to UPenn where he joined the faculty in 1956. He served as chair of the department of pathology from 1967-1973, and as the first director of the
University of Pennsylvania Cancer Center, now known as the
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The finding was a turning point. Until then, most scientists believed viruses to be the cause of cancer. This new avenue of research fueled decades of scientific research that produced monumental steps in the treatment of cancer.
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Nowell credits his ultimate discovery of the so-called
Philadelphia chromosome to an accident he made while cleaning a research slide. While working in a laboratory at UP studying samples of
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In 1960, Nowell and his graduate student David
Hungerford discovered the Philadelphia chromosome, an abnormally small chromosome in the cancerous white blood cells of patients with
236:, he happened to wash his slides with tap water instead of a laboratory solution. When he then studied the slides under his microscope, he saw that the water had caused the cells'
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in San
Francisco. He joined the University of Pennsylvania faculty in 1956. At the time of his death he was chairman of the department of pathology and laboratory medicine at UP.
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in
Philadelphia. Analyzing the white blood cells of patients with this particular form of leukemia, Hungerford consistently noticed that the
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for their combined work in this area. At present, drugs have been developed that hold chronic myeloid leukemia in remission for years.
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Peter Carey Nowell was born in
Philadelphia. His mother was a writer and a teacher, and his father was an electrical engineer for the
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was capable of triggering mitosis, which allowed scientists to grow cells in culture for the study for cancer.
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Gradually, technology improved enough to allow scientists to visualize the genetic material in greater detail.
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In 1952 Nowell married Helen Walker Worst. They had five children. His wife died in 2004.
175:(February 8, 1928 – December 26, 2016) was a cancer researcher and co-discoverer of the
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Jr., a geneticist at Fox Chase, made further progress linking genetics and cancer.
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2011 AACC-NACB award for outstanding contributions to clinical chemistry
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and other targeted therapies possible. In the 1960s, he published that
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Perelman School of
Medicine at the University of Pennsylvania faculty
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Perelman School of
Medicine at the University of Pennsylvania alumni
489:"Discovery of the Philadelphia chromosome: a personal perspective"
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in
Middletown, Connecticut, in 1948 and a medical degree from the
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Recipients of the Lasker–DeBakey
Clinical Medical Research Award
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Peter Nowell . . revolutionized cancer research - by accident.
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He received a bachelor's degree in biology and chemistry from
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Members of the United States National Academy of Sciences
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1987 de Villiers International Achievement Award of the
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Benjamin Franklin Medal (Franklin Institute) laureates
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Deaths from Alzheimer's disease in the United States
446:"Peter Nowell Obituary - Philadelphia, Pennsylvania"
425:"1998 Albert Lasker Clinical Medical Research Award"
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1980 Simon M. Shubitz Cancer Prize and Lectureship
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537:"Legacy of the Philadelphia Chromosome Discovery"
731:Members of the American Philosophical Society
390:for Distinguished Achievement in the Sciences
274:In 1998, Nowell, Rowley and Knudson received
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369:American Society for Investigative Pathology
338:American Society for Investigative Pathology
706:Members of the National Academy of Medicine
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364:General Motors Cancer Research Foundation
228:Discovery of the Philadelphia chromosome
639:American Academy of Arts & Sciences
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248:(1927-1993), a graduate student at the
103:Helen Walker Worst (m. 1962; died 2004)
382:American Academy of Arts and Sciences
212:Naval Radiological Defense Laboratory
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367:1997 Gold-Headed Cane Award of the
487:Nowell, Peter C. (August 1, 2007).
400:in Medicine and Biomedical Research
303:at the University of Pennsylvania.
294:in 1952. He spent two years in the
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282:University of Pennsylvania career
476:Washington Post, 12 January 2017
336:1986 Rous-Whipple Award of the
356:American Philosophical Society
290:in 1948 and his M.D. from the
286:Nowell received his B.A. from
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344:Leukemia and Lymphoma Society
327:1976 Elected member of the
751:Scientists from Philadelphia
736:Physicians from Philadelphia
659:"Peter C. Nowell - AACC.org"
380:2009 Elected fellow of the
354:1993 Elected member of the
348:1991 Elected member of the
329:National Academy of Sciences
308:chronic myelogenous leukemia
721:Fellows of the AACR Academy
403:2014 Elected fellow of the
398:Albany Medical Center Prize
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741:Wesleyan University alumni
377:for Basic Medical Research
292:University of Pennsylvania
222:Philadelphia, Pennsylvania
204:University of Pennsylvania
181:University of Pennsylvania
156:University of Pennsylvania
79:University of Pennsylvania
60:Philadelphia, Pennsylvania
43:Philadelphia, Pennsylvania
16:American cancer researcher
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234:chronic myeloid leukemia
388:Benjamin Franklin Medal
250:Fox Chase Cancer Center
206:in 1952. He joined the
177:Philadelphia chromosome
94:Philadelphia chromosome
301:Abramson Cancer Center
256:was noticeably short.
193:Bell Telephone Company
566:"Peter C. Nowell, MD"
362:Charles S. Mott Prize
350:Institute of Medicine
696:American oncologists
615:search.amphilsoc.org
611:"APS Member History"
288:Wesleyan University
200:Wesleyan University
73:Wesleyan University
316:phytohemagglutinin
244:He partnered with
173:Peter Carey Nowell
635:"Peter C. Nowell"
591:www.nasonline.org
587:"Peter C. Nowell"
543:on March 21, 2013
269:Alfred G. Knudson
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135:Scientific career
92:Discovery of the
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375:Lasker Award
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149:Institutions
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128:Lasker Award
55:(2016-12-26)
23:Peter Nowell
691:2016 deaths
686:1928 births
238:chromosomes
81:(M.D. 1952)
75:(B.A. 1948)
680:Categories
644:2022-03-15
620:2022-03-15
596:2022-03-15
451:Legacy.com
411:References
35:1928-02-08
547:March 31,
430:March 31,
187:Biography
523:17671636
312:imatinib
108:Children
514:1934591
296:US Navy
119:Michael
117:Kristin
111:Timothy
521:
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396:2013
386:2010
373:1998
360:1989
322:Awards
141:Fields
124:Awards
115:Sharon
100:Spouse
113:Karen
666:2016
573:2016
549:2013
519:PMID
459:2016
432:2013
208:Navy
50:Died
29:Born
509:PMC
501:doi
497:117
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