148:. This finding set in train a surge of interest in this pathway, leading amongst other things, to the recognition of its role in a number of human cancers and to the development of a novel anti-cancer drug that specifically targets the pathway. Ingham was in the vanguard of researchers to adopt the
164:
Ingham has authored or co-authored over 180 peer-reviewed scientific primary research papers and review articles. Notable amongst the latter are his 1988 review of the
Molecular Genetics of embryonic Pattern formation in Drosophila and his 2001 review, co-authored with Andrew McMahon, on the
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genes using the technique of in situ hybridisation. These studies led to his interest in what is now known as the
Hedgehog signalling pathway; Ingham's genetic studies identified the core components of this pathway and in particular the role of the
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as key epigenetic regulators throughout the animal kingdom. Subsequently, he pioneered the molecular analysis of the process of segmentation in the
Drosophila embryo, through the simultaneous analysis the expression of patterns of
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protein as the receptor for the
Hedgehog ligand. In 1993, in collaboration with Andy McMahon and Cliff Tabin, Ingham's research group discovered the vertebrate homologues of the Drosophila hedgehog gene, including
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129:, which he named trithorax (trx). Using genetic mosaic analysis, he showed that the trx gene is required for the maintenance of the determined state of cells, presaging the current understanding of the
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Ingham, Philip & Robert
Whittle (1980). "Trithorax: a new homoeotic mutation of Drosophila melanogaster causing transformations of abdominal and thoracic imaginal segments".
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from 2013-2017. In 2014 he was awarded the
Waddington Medal by the British Society for Developmental Biology. He has lived and worked in Singapore since 2005.
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Howard, K & Ingham, P (1986). "Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the
Drosophila blastoderm".
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in 2002. In 2005, he became the second recipient of the Medal of the
Genetics Society of Great Britain and in 2007 was elected an Honorary Fellow of the
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under the supervision of J Robert S Whittle before moving to the
Laboratoire de Génétique Moleculaire des Eukaryotes in Strasbourg, France, as a
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Ingham, PW (1985). "A clonal analysis of the requirement for the trithorax gene in the diversification of segments in
Drosophila".
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European Exchange Programme fellow. He returned to the UK in 1982, joining the Imperial Cancer Research Fund (ICRF, now known as
69:, where after initially reading Philosophy and Theology he graduated in Genetics. He gained his Doctorate of Philosophy from the
42:
323:
156:, as a model for the analysis of vertebrate development and more recently for the study of processes related to human diseases.
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Forbes, AJ; Nakano, Y; Taylor, AM & Ingham, PW (1993). "Genetic analysis of hedgehog signalling in the Drosophila embryo".
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41:, currently the Toh Kian Chui Distinguished Professor at the Lee Kong Chian School of Medicine, a partnership between
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113:. He has served on numerous international Scientific Advisory Boards and funding committees and was President of the
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Ingham, PW; Taylor, AM & Nakano, Y (1991). "Role of the Drosophila patched gene in positional signalling".
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in Cambridge, he re-joined the ICRF as a staff scientist, remaining there for ten years before moving to the
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222:› Alumni Career Profiles › Philip Ingham (1973 Leaver) – Professor of Developmental Biology
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Ingham PW (1988). "The molecular genetics of embryonic pattern formation in Drosophila".
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Centre for Developmental and Biomedical Genetics. He was elected a member of the
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Biologists Find Key Genes That Shape Patterning of Embryos – New York Times
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Genetics Society Website > Prizes > Genetics Society Medal 2005
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As a graduate student, Ingham isolated a novel homoeotic mutation in
625:"Hedgehog signaling in animal development: paradigms and principles"
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List of University of Sussex alumni – Knowledge (XXG), the 💕
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Fellows of the Academy of Medical Sciences (United Kingdom)
81:) as a post-doctoral research fellow in the laboratory of
85:. After a brief spell as a Research Scientist at the
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Pin by Cancer Research UK on Skin Cancer | Pinterest
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396:Journal of Embryology and Experimental Morphology
165:Principles and Paradigms of Hedgehog signalling.
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87:MRC Laboratory of Molecular Biology
1051:Alumni of the University of Sussex
300:10.1002/j.1460-2075.1995.tb07332.x
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673:Scienceblog.cancerresearchuk.org
265:Our History | The Bateson Centre
63:Merchant Taylors' School, Crosby
43:Nanyang Technological University
623:Ingham PW, McMahon AP (2001).
478:10.1242/dev.119.Supplement.115
361:Molecular and General Genetics
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348:An interview with Phil Ingham
1036:Fellows of the Royal Society
435:10.1016/0092-8674(86)90018-8
324:"2002 Royal Society Fellows"
284:"EMBO members elected 1995"
111:Royal College of Physicians
103:Academy of Medical Sciences
93:, where he established the
65:near Liverpool and then at
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838:David Malcolm James Lilley
105:in 2001 and Fellow of the
67:Queens' College, Cambridge
1031:Scientists from Liverpool
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101:in 1995, a Fellow of the
860:Brian Cecil Joseph Moore
227:21 November 2015 at the
131:Trithorax-group proteins
121:Scientific contributions
798:Christopher Hawkesworth
629:Genes & Development
91:University of Sheffield
61:Ingham was educated at
831:John Vincent Kilmartin
927:Andrew Benjamin Smith
20:Philip William Ingham
741:Michael John Crawley
71:University of Sussex
51:University of Exeter
33:(born 19 March 1955
1021:British geneticists
940:Nicholas Strausfeld
906:Thomas Maurice Rice
901:David William Rhind
768:David Henry Dolphin
586:1988Natur.335...25I
513:1991Natur.353..184I
934:Anthony John Stace
886:Peter J. Ratcliffe
813:David Ish-Horowicz
788:Jean-Pierre Hansen
642:10.1101/gad.938601
373:10.1007/bf00271751
294:(13): 3288. 1995.
197:"Welcome to nginx"
83:David Ish-Horowicz
79:Cancer Research UK
16:British geneticist
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252:"LMB Alumni List"
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991:Carl Wunsch
911:Roy Sambles
876:Eric Priest
844:Terry Lyons
466:Development
154:Danio rerio
1015:Categories
950:Ian Wilmut
896:Miles Reid
472:: 115–24.
402:: 349–65.
169:References
127:Drosophila
39:geneticist
891:Mary Rees
763:Anne Dell
150:zebrafish
136:pair rule
35:Liverpool
715:elected
651:11731473
451:28770534
268:Archived
225:Archived
959:Foreign
724:Fellows
717:in 2002
711:of the
709:Fellows
610:4311200
602:2901040
582:Bibcode
537:4361236
529:1653906
509:Bibcode
486:8049467
443:3955654
408:4093752
381:7514185
207:15 June
141:Patched
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647:PMID
598:PMID
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482:PMID
439:PMID
423:Cell
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209:2014
31:FRCP
637:doi
590:doi
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517:doi
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