551:
528:
2858:
425:
450:
3573:
3543:
3528:
3408:
3423:
809:
3453:
3558:
3438:
3513:
3498:
3483:
3468:
802:
557:
456:
38:
3588:
1771:, require the binding at this docking site. Small molecule allosteric activators of PDPK1 were shown to selectively inhibit activation of substrates that require docking site interaction. These compounds do not bind to the active site and allow PDPK1 to activate other substrates that do not require docking site interaction. PDPK1 is constitutively active and at present, there is no known inhibitor proteins for PDPK1.
5765:
2937:
Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT (1998). "Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B".
64:
1647:
Plant PDK1 plays an important role in regulating PIN-mediated auxin transport, and is thus involved in various developmental processes, such as embryonic development, lateral root formation, vasculature patterning, apical hook formation, gravitropism and phototropism.
2446:
Chun J, Kwon T, Lee E, Suh PG, Choi EJ, Sun Kang S (October 2002). "The Na(+)/H(+) exchanger regulatory factor 2 mediates phosphorylation of serum- and glucocorticoid-induced protein kinase 1 by 3-phosphoinositide-dependent protein kinase 1".
3628:
3913:
3572:
3542:
3135:"Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2"
3527:
1637:
Mice lacking PDPK1 die during early embryonic development, indicating that this enzyme is critical for transmitting the growth-promoting signals necessary for normal mammalian development.
2408:
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ (September 1998). "Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1".
3621:
2977:"Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha"
3065:
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ (1998). "Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1".
2268:"A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1"
3614:
3821:
2740:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
2180:"Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343"
564:
463:
22:
3311:"Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo"
1839:
1640:
Mice that are deficient in PDPK1 have a ≈40% decrease in body mass, mild glucose intolerance, and are resistant to cancer brought about by hyperactivation of the
1732:. PDPK1 however does not require membrane lipid binding for the efficient phosphorylation of most of its substrates in the cytosol (not at the cell membrane).
4369:
5208:
3672:
3407:
2867:"Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK"
1767:
binding sites; the substrate binding site, the ATP binding site, and the docking site (also known as PIF pocket). Several PDPK1 substrates including S6K and
3422:
5317:
4055:
3942:
1774:
The activation of PDPK1's main effector, AKT, is believed to require a proper orientation of the kinase and PH domains of PDPK1 and AKT at the membrane.
1753:
1715:
1699:
1277:
386:
4330:
3452:
1258:
3557:
3437:
5303:
4768:
3659:
3641:
3512:
3497:
3482:
3467:
5405:
5286:
1749:
1711:
1695:
2689:
Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M (1997).
4992:
3861:
3096:"Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1"
2224:
Hodgkinson CP, Sale GJ (January 2002). "Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment".
5785:
5056:
4031:
3387:
1925:
1907:
5312:
2900:
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G (1998). "Phosphorylation and activation of p70s6k by PDK1".
2566:
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
1959:"Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma"
550:
3846:
5369:
5044:
3587:
1516:
527:
5484:
4301:
4291:
3976:
1509:
3268:"A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans"
4983:
1943:
5252:
4924:
4286:
4277:
1894:
1873:
2691:"3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase"
449:
424:
5640:
2597:"Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha"
1890:
2043:"A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation"
2006:
Mora A, Komander D, van Aalten DM, Alessi DR (April 2004). "PDK1, the master regulator of AGC kinase signal transduction".
61:
4667:
4164:
4155:
3812:
3758:
2806:"3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro"
1957:
Scortegagna M, Ruller C, Feng Y, Lazova R, Kluger H, Li JL, De SK, Rickert R, Pellecchia M, Bosenberg M, Ronai ZA (2014).
5755:
1869:
3855:
3581:: Crystal Structure Of N1-phenyl]amino]-4-pyrimidinyl]amino]propyl]-2,2-dimethylpropanediamide Complexed with Human PDK1
3551:: CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO DIC4-PHOSPHATIDYLINOSITOL (3,4,5)-TRISPHOSPHATE
366:
3355:
1783:
1630:. An important role for PDPK1 is in the signaling pathways activated by several growth factors and hormones including
563:
462:
3606:
4879:
4697:
4193:
5625:
556:
455:
357:, PDK1, PDPK2, PRO0461, PDPK2P, Phosphoinositide-dependent kinase-1, 3-phosphoinositide dependent protein kinase 1
5741:
5728:
5715:
5702:
5689:
5676:
5663:
4869:
4864:
4859:
4849:
4844:
4839:
4829:
4624:
4399:
3995:
3380:
2309:"Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA"
5635:
5790:
5589:
5532:
5092:
5083:
5034:
3800:
3645:
3359:
3174:"PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2"
1322:
374:
1756:
which is important in localization and activation of some of membrane associated PDPK1's substrates including
3536:: CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO INOSITOL (1,3,4,5)-TETRAKISPHOSPHATE
3225:"Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway"
2361:"Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway"
5537:
5392:
4815:
1303:
3016:"Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B"
2857:
2178:
Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S (July 2001).
2090:
Tan S, Zhang X, Kong W, Yang XL, Molnár G, Vondráková Z, Filepová R, Petrášek J, Friml J, Xue HW (2020).
5558:
5477:
4091:
1725:
1719:
1707:
1691:
1641:
438:
5630:
4658:
3373:
3185:
3027:
2947:
2909:
2820:
2702:
2608:
2484:"Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3"
2092:"The lipid code-dependent phosphoswitch PDK1–D6PK activates PIN-mediated auxin efflux in Arabidopsis"
1821:
2805:
2646:
Moser BA, Dennis PB, Pullen N, Pearson RB, Williamson NA, Wettenhall RE, Kozma SC, Thomas G (1997).
353:
5594:
3094:
Currie RA, Walker KS, Gray A, Deak M, Casamayor A, Downes CP, Cohen P, Alessi DR, Lucocq J (1999).
1488:
1484:
1455:
1425:
1421:
1392:
5166:
5795:
5527:
5269:
5223:
3211:
3053:
2846:
2728:
2634:
2119:
398:
3172:
Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes CP, Alessi DR (1999).
1615:
1492:
1463:
1459:
1429:
1400:
1396:
1740:
The structure of PDPK1 can be divided into two domains; the kinase or catalytic domain and the
4529:
4238:
3336:
3297:
3254:
3203:
3160:
3121:
3082:
3045:
3002:
2963:
2925:
2888:
2838:
2792:
2757:
2720:
2677:
2626:
2583:
2554:
2505:
2464:
2425:
2390:
2338:
2289:
2241:
2201:
2160:
2111:
2072:
2023:
1988:
1827:
346:
54:
5573:
5568:
5542:
5470:
5122:
4364:
4354:
4349:
4267:
4258:
4188:
4179:
4125:
4116:
3773:
3326:
3318:
3287:
3279:
3244:
3236:
3193:
3150:
3142:
3111:
3103:
3074:
3035:
2992:
2984:
2955:
2917:
2878:
2828:
2782:
2749:
2710:
2667:
2659:
2616:
2575:
2544:
2536:
2495:
2456:
2417:
2380:
2372:
2328:
2320:
2279:
2233:
2191:
2150:
2103:
2062:
2054:
2015:
1978:
1970:
1768:
1619:
643:
574:
518:
473:
2041:
Frödin M, Antal TL, Dümmler BA, Jensen CJ, Deak M, Gammeltoft S, Biondi RM (October 2002).
808:
394:
5620:
5604:
5517:
4948:
4019:
4014:
4009:
2771:"Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta"
801:
618:
3189:
3031:
2951:
2913:
2824:
2706:
2612:
5769:
5658:
5599:
3331:
3310:
3249:
3224:
3155:
3134:
3116:
3095:
2997:
2976:
2549:
2528:
2385:
2360:
1983:
1958:
37:
3292:
3267:
3198:
3173:
3040:
3015:
2833:
2753:
2715:
2690:
2672:
2647:
2621:
2596:
2460:
2333:
2308:
2067:
2042:
1192:
1187:
1182:
1177:
1172:
1167:
1162:
1157:
1152:
1147:
1142:
1137:
1132:
1127:
1122:
1117:
1112:
1107:
1102:
1097:
1092:
1087:
1082:
1077:
1072:
1067:
1062:
1057:
1052:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
5779:
5563:
5522:
4072:
4004:
2579:
2139:"Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI"
2123:
1718:. However, PDPK1 is believed to be constitutively active and does not always require
837:
3215:
3057:
2850:
2091:
378:
5512:
4943:
3768:
2732:
2638:
1569:
636:
415:
3078:
2421:
1728:
are only required for the activation at the membrane of some substrates including
2959:
2921:
2595:
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P (1997).
2019:
1033:
negative regulation of transforming growth factor beta receptor signaling pathway
402:
5736:
5671:
5507:
5149:
4781:
4721:
4604:
4524:
4248:
3322:
3146:
3107:
2540:
1930:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1912:
National Center for
Biotechnology Information, U.S. National Library of Medicine
5764:
3240:
2376:
2266:
Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR (July 2000).
719:
5237:
3711:
2307:
Biondi RM, Cheung PC, Casamayor A, Deak M, Currie RA, Alessi DR (March 2000).
2107:
535:
432:
382:
2787:
2770:
2324:
5710:
5684:
4198:
2359:
Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA (June 1999).
1745:
1741:
1222:
779:
657:
602:
589:
501:
488:
390:
3340:
3301:
3283:
3258:
3207:
3164:
2883:
2866:
2558:
2509:
2500:
2483:
2468:
2394:
2342:
2293:
2284:
2267:
2245:
2205:
2196:
2179:
2164:
2155:
2138:
2115:
2076:
2058:
2027:
1992:
3125:
3086:
3049:
3006:
2967:
2929:
2892:
2842:
2796:
2761:
2724:
2681:
2663:
2630:
2587:
2429:
1556:
1551:
4554:
4449:
4444:
4439:
1974:
1595:
1540:
1367:
1348:
2648:"Dual requirement for a newly identified phosphorylation site in p70s6k"
5213:
5191:
5186:
5176:
5171:
4973:
4968:
4963:
4958:
4953:
4938:
4933:
4584:
4549:
3788:
3783:
3778:
3223:
Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA (1999).
1631:
1577:
1334:
1289:
3416:: HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN PDK1 CATALYTIC DOMAIN
2988:
2237:
1028:
positive regulation of release of sequestered calcium ion into cytosol
323:
319:
315:
311:
307:
303:
299:
295:
291:
287:
283:
279:
275:
271:
267:
263:
259:
255:
251:
247:
243:
239:
235:
231:
227:
223:
219:
215:
211:
207:
203:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
83:
5723:
5493:
5443:
5438:
5433:
5428:
5423:
5418:
5413:
5364:
5359:
5354:
5349:
5344:
5327:
5322:
5196:
5181:
5132:
5127:
5112:
5107:
5102:
5097:
5071:
5066:
5061:
5049:
5027:
5022:
4914:
4889:
4564:
4389:
4384:
4379:
4374:
4359:
4203:
4140:
4135:
4130:
4106:
3932:
3927:
3901:
3896:
3891:
3881:
3876:
3866:
3706:
3637:
3431:: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE
1803:
1764:
1607:
1584:
1524:
1244:
2975:
Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR (1998).
5697:
5339:
5332:
5242:
5139:
5039:
5017:
5012:
5007:
5002:
4997:
4909:
4904:
4899:
4894:
4884:
4854:
4834:
4711:
4706:
4687:
4682:
4672:
4648:
4643:
4638:
4614:
4609:
4599:
4594:
4589:
4579:
4559:
4544:
4539:
4534:
4514:
4509:
4499:
4494:
4489:
4484:
4479:
4469:
4464:
4459:
4454:
4434:
4429:
4424:
4419:
4414:
4409:
4394:
4344:
4339:
4233:
4228:
4223:
4218:
4213:
4208:
4169:
4101:
4096:
4045:
4040:
3966:
3961:
3956:
3922:
3914:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
3716:
3701:
3696:
3691:
3686:
3681:
1845:
1815:
1809:
1690:
through PDPK1's interaction with membrane phospholipids including
1594:
in humans. It is implicated in the development and progression of
1207:
1203:
5232:
5159:
5154:
5144:
5117:
4874:
4824:
4805:
4800:
4795:
4790:
4745:
4740:
4735:
4730:
4677:
4633:
4574:
4569:
4519:
4504:
4474:
4404:
4320:
4315:
4310:
4243:
4145:
4086:
4081:
3985:
3951:
3836:
3831:
3826:
3795:
3763:
3751:
3746:
3741:
3731:
3726:
3461:: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH LY333531
1797:
1791:
1703:
1687:
1591:
370:
5466:
5390:
4766:
3657:
3610:
3566:: CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN
3369:
2769:
Meier R, Alessi DR, Cron P, Andjelković M, Hemmings BA (1997).
1153:
cellular response to brain-derived neurotrophic factor stimulus
817:
5201:
3736:
3721:
3446:: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH UCN-01
3365:
2804:
Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J (1998).
1833:
1757:
1729:
1627:
1623:
1611:
1183:
positive regulation of vascular endothelial cell proliferation
1173:
positive regulation of blood vessel endothelial cell migration
1163:
positive regulation of protein localization to plasma membrane
3521:: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-8
3506:: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-3
3491:: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-1
3476:: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-2
2865:
Dalby KN, Morrice N, Caudwell FB, Avruch J, Cohen P (1998).
1073:
negative regulation of cardiac muscle cell apoptotic process
1083:
negative regulation of toll-like receptor signaling pathway
5462:
3266:
Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G (1999).
3014:
Anderson KE, Coadwell J, Stephens LR, Hawkins PT (1998).
1193:
negative regulation of endothelial cell apoptotic process
2529:"The PI3K-PDK1 connection: more than just a road to PKB"
626:
1782:
Phosphoinositide-dependent kinase-1 has been shown to
5753:
1053:
cellular response to epidermal growth factor stimulus
791:
1023:
stimulatory C-type lectin receptor signaling pathway
876:
3-phosphoinositide-dependent protein kinase activity
5649:
5613:
5582:
5551:
5500:
5404:
5302:
5285:
5268:
5251:
5222:
5082:
4982:
4923:
4814:
4780:
4720:
4696:
4657:
4623:
4329:
4300:
4276:
4257:
4178:
4154:
4115:
4071:
4054:
4030:
3994:
3975:
3941:
3912:
3845:
3811:
3671:
1477:
1448:
1414:
1385:
1886:
1884:
1882:
1865:
1863:
1861:
1748:functions mainly in the interaction of PDPK1 with
1158:epidermal growth factor receptor signaling pathway
1138:regulation of I-kappaB kinase/NF-kappaB signaling
573:
472:
23:Pyruvate dehydrogenase lipoamide kinase isozyme 1
2441:
2439:
2354:
2352:
2261:
2259:
2257:
2255:
2219:
2217:
2215:
1148:negative regulation of neuron apoptotic process
16:Protein-coding gene in the species Homo sapiens
3596:: STRUCTURE OF PDK1-S241A MUTANT KINASE DOMAIN
1891:GRCm38: Ensembl release 89: ENSMUSG00000024122
1706:indirectly regulates PDPK1 by phosphorylating
1008:negative regulation of protein kinase activity
5478:
3673:Non-specific serine/threonine protein kinases
3622:
3381:
1581:3-phosphoinositide-dependent protein kinase-1
1188:positive regulation of sprouting angiogenesis
1063:positive regulation of phospholipase activity
8:
3356:3-phosphoinositide-dependent+protein+kinase
3309:Casamayor A, Morrice NA, Alessi DR (1999).
2482:Sato S, Fujita N, Tsuruo T (October 2002).
1870:GRCh38: Ensembl release 89: ENSG00000140992
5485:
5471:
5463:
5401:
5387:
4777:
4763:
4056:Goodpasture-antigen-binding protein kinase
3668:
3654:
3629:
3615:
3607:
3388:
3374:
3366:
1754:phosphatidylinositol (3,4,5)-trisphosphate
1716:phosphatidylinositol (3,4,5)-trisphosphate
1700:phosphatidylinositol (3,4,5)-trisphosphate
1218:
998:regulation of transcription, DNA-templated
833:
614:
513:
410:
72:
4769:Serine/threonine-specific protein kinases
3943:(isocitrate dehydrogenase (NADP+)) kinase
3660:Serine/threonine-specific protein kinases
3642:Serine/threonine-specific protein kinases
3358:at the U.S. National Library of Medicine
3330:
3291:
3248:
3197:
3154:
3115:
3039:
2996:
2882:
2832:
2786:
2714:
2671:
2620:
2548:
2499:
2384:
2332:
2283:
2195:
2154:
2066:
1982:
1610:, which is crucial for the activation of
5304:Receptor protein serine/threonine kinase
1093:regulation of endothelial cell migration
881:protein serine/threonine kinase activity
5760:
5287:Low-density-lipoprotein receptor kinase
3403:
1857:
1750:phosphatidylinositol (3,4)-bisphosphate
1712:phosphatidylinositol (3,4)-bisphosphate
1696:phosphatidylinositol (3,4)-bisphosphate
1168:activation of protein kinase B activity
27:
4032:Fas-activated serine/threonine kinase
1108:regulation of mast cell degranulation
1098:cellular response to insulin stimulus
1058:Fc-epsilon receptor signaling pathway
1003:extrinsic apoptotic signaling pathway
578:
539:
534:
477:
436:
431:
7:
5313:Bone morphogenetic protein receptors
2527:Vanhaesebroeck B, Alessi DR (2000).
3847:Dephospho-(reductase kinase) kinase
2137:Barry FA, Gibbins JM (April 2002).
1178:positive regulation of angiogenesis
4302:G-protein coupled receptor kinases
1474:
1445:
1411:
1382:
1358:
1339:
1313:
1294:
1268:
1249:
1118:type B pancreatic cell development
1113:peptidyl-threonine phosphorylation
796:
714:
652:
631:
14:
4292:Beta adrenergic receptor kinase-2
3977:(tyrosine 3-monooxygenase) kinase
1123:T cell receptor signaling pathway
993:intracellular signal transduction
5763:
4984:Mitogen-activated protein kinase
3586:
3571:
3556:
3541:
3526:
3511:
3496:
3481:
3466:
3451:
3436:
3421:
3406:
2856:
1686:. PDPK1 functions downstream of
886:phospholipase activator activity
807:
800:
562:
555:
549:
526:
461:
454:
448:
423:
36:
5370:Anti-Müllerian hormone receptor
5253:(acetyl-CoA carboxylase) kinase
4925:(RNA-polymerase)-subunit kinase
4287:Beta adrenergic receptor kinase
4278:Beta adrenergic receptor kinase
1133:actin cytoskeleton organization
1088:peptidyl-serine phosphorylation
4993:Extracellular signal-regulated
818:More reference expression data
780:More reference expression data
1:
5057:P38 mitogen-activated protein
4156:cGMP-dependent protein kinase
4117:cAMP-dependent protein kinase
3813:Pyruvate dehydrogenase kinase
3759:Ataxia telangiectasia mutated
3199:10.1016/S0960-9822(99)80186-9
3133:Kobayashi T, Cohen P (1999).
3079:10.1126/science.281.5385.2042
3041:10.1016/S0960-9822(98)70274-X
2834:10.1016/S0960-9822(98)70037-5
2754:10.1016/S0378-1119(97)00411-3
2716:10.1016/S0960-9822(06)00336-8
2622:10.1016/S0960-9822(06)00122-9
2461:10.1016/s0006-291x(02)02428-2
2449:Biochem. Biophys. Res. Commun
2422:10.1126/science.281.5385.2042
547:
446:
5786:Genes on human chromosome 16
3856:AMP-activated protein kinase
2983:. 331 ( Pt 1) (1): 299–308.
2960:10.1126/science.279.5351.710
2922:10.1126/science.279.5351.707
2580:10.1016/0378-1119(94)90802-8
2020:10.1016/j.semcdb.2003.12.022
1763:The kinase domain has three
1043:transcription, DNA-templated
4771:(EC 2.7.11.21-EC 2.7.11.30)
3317:. 342 ( Pt 2) (2): 287–92.
3141:. 339 ( Pt 2) (2): 319–28.
3102:. 337 ( Pt 3) (3): 575–83.
1103:protein autophosphorylation
5812:
4698:Elongation factor 2 kinase
3662:(EC 2.7.11.1-EC 2.7.11.20)
1143:calcium-mediated signaling
20:
5641:Michaelis–Menten kinetics
5400:
5386:
5093:MAP kinase kinase kinases
4776:
4762:
4625:Myosin light-chain kinase
4331:Ca2+/calmodulin-dependent
3996:Myosin-heavy-chain kinase
3667:
3653:
3401:
3323:10.1042/0264-6021:3420287
3147:10.1042/0264-6021:3390319
3108:10.1042/0264-6021:3370575
2541:10.1042/0264-6021:3460561
2108:10.1038/s41477-020-0648-9
1926:"Mouse PubMed Reference:"
1908:"Human PubMed Reference:"
1555:
1550:
1546:
1539:
1523:
1504:
1481:
1452:
1441:
1418:
1389:
1378:
1365:
1361:
1346:
1342:
1333:
1320:
1316:
1301:
1297:
1288:
1275:
1271:
1256:
1252:
1243:
1228:
1221:
1217:
1201:
836:
832:
815:
799:
790:
777:
726:
717:
680:bronchial epithelial cell
664:
655:
625:
617:
613:
596:
583:
546:
525:
516:
512:
495:
482:
445:
422:
413:
409:
364:
361:
351:
344:
339:
80:
75:
58:
53:
48:
44:
35:
30:
5533:Diffusion-limited enzyme
5393:Dual-specificity kinases
3360:Medical Subject Headings
3241:10.1093/emboj/18.11.3024
2788:10.1074/jbc.272.48.30491
2535:. 346 Pt 3 (3): 561–76.
2377:10.1093/emboj/18.11.3024
1710:which in turn generates
1587:which is encoded by the
1517:Chr 17: 24.29 – 24.37 Mb
871:insulin receptor binding
758:anterior amygdaloid area
730:Rostral migratory stream
700:external globus pallidus
21:Not to be confused with
4816:Cyclin-dependent kinase
1078:focal adhesion assembly
1068:protein phosphorylation
861:protein kinase activity
696:mucosa of sigmoid colon
3284:10.1101/gad.13.11.1438
2884:10.1074/jbc.273.3.1496
2501:10.1074/jbc.M205141200
2325:10.1093/emboj/19.5.979
2285:10.1074/jbc.M000421200
2197:10.1074/jbc.M102940200
2156:10.1074/jbc.M200482200
901:protein kinase binding
5626:Eadie–Hofstee diagram
5559:Allosteric regulation
2664:10.1128/MCB.17.9.5648
2008:Semin. Cell Dev. Biol
1726:Phosphatidylinositols
1720:phosphatidylinositols
1708:phosphatidylinositols
1692:phosphatidylinositols
1510:Chr 16: 2.54 – 2.6 Mb
1038:hyperosmotic response
866:phospholipase binding
766:epithelium of stomach
672:middle temporal gyrus
541:Chromosome 17 (mouse)
439:Chromosome 16 (human)
5636:Lineweaver–Burk plot
4659:Phosphorylase kinase
2059:10.1093/emboj/cdf551
1975:10.1038/onc.2013.383
1944:"Entrez Gene: PDPK1"
1722:for its activities.
1614:/PKB and many other
1018:T cell costimulation
972:postsynaptic density
851:transferase activity
762:facial motor nucleus
742:ventromedial nucleus
76:List of PDB id codes
49:Available structures
3190:1999CBio....9..393B
3032:1998CBio....8..684A
2952:1998Sci...279..710S
2914:1998Sci...279..707P
2825:1998CBio....8...69A
2707:1997CBio....7..776A
2613:1997CBio....7..261A
1656:PDPK1 stands for 3-
1048:platelet activation
977:cytoplasmic vesicle
738:seminiferous tubule
5595:Enzyme superfamily
5528:Enzyme promiscuity
5270:Tropomyosin kinase
5224:Tau-protein kinase
1606:PDPK1 is a master
1323:ENSMUSG00000024122
986:Biological process
915:Cellular component
856:nucleotide binding
844:Molecular function
754:olfactory tubercle
5751:
5750:
5460:
5459:
5456:
5455:
5452:
5451:
5382:
5381:
5378:
5377:
4758:
4757:
4754:
4753:
4239:Protein kinase N1
4194:Protein kinase Cζ
3604:
3603:
2989:10.1042/bj3310299
2238:10.1021/bi010719z
1828:Protein kinase N1
1822:Protein kinase Mζ
1566:
1565:
1562:
1561:
1535:
1534:
1500:
1499:
1471:
1470:
1437:
1436:
1408:
1407:
1374:
1373:
1355:
1354:
1329:
1328:
1310:
1309:
1284:
1283:
1265:
1264:
1213:
1212:
828:
827:
824:
823:
786:
785:
773:
772:
734:nucleus accumbens
711:
710:
692:corpus epididymis
609:
608:
508:
507:
403:PDPK1 - orthologs
335:
334:
331:
330:
59:Ortholog search:
5803:
5768:
5767:
5759:
5631:Hanes–Woolf plot
5574:Enzyme activator
5569:Enzyme inhibitor
5543:Enzyme catalysis
5487:
5480:
5473:
5464:
5402:
5388:
5035:C-Jun N-terminal
4778:
4764:
4268:Rhodopsin kinase
4259:Rhodopsin kinase
4189:Protein kinase C
4180:Protein kinase C
4165:Protein kinase G
4126:Protein kinase A
3737:Protein kinase B
3669:
3655:
3631:
3624:
3617:
3608:
3590:
3575:
3560:
3545:
3530:
3515:
3500:
3485:
3470:
3455:
3440:
3425:
3410:
3390:
3383:
3376:
3367:
3344:
3334:
3305:
3295:
3262:
3252:
3219:
3201:
3168:
3158:
3129:
3119:
3090:
3073:(5385): 2042–5.
3061:
3043:
3010:
3000:
2971:
2933:
2908:(5351): 707–10.
2896:
2886:
2861:
2860:
2854:
2836:
2810:
2800:
2790:
2765:
2736:
2718:
2685:
2675:
2642:
2624:
2591:
2562:
2552:
2514:
2513:
2503:
2479:
2473:
2472:
2443:
2434:
2433:
2416:(5385): 2042–5.
2405:
2399:
2398:
2388:
2356:
2347:
2346:
2336:
2304:
2298:
2297:
2287:
2278:(27): 20806–13.
2263:
2250:
2249:
2221:
2210:
2209:
2199:
2175:
2169:
2168:
2158:
2134:
2128:
2127:
2087:
2081:
2080:
2070:
2053:(20): 5396–407.
2038:
2032:
2031:
2003:
1997:
1996:
1986:
1954:
1948:
1947:
1940:
1934:
1933:
1922:
1916:
1915:
1904:
1898:
1888:
1877:
1867:
1769:Protein kinase C
1662:hosphoinositide-
1568:In the field of
1548:
1547:
1519:
1512:
1495:
1475:
1466:
1446:
1442:RefSeq (protein)
1432:
1412:
1403:
1383:
1359:
1340:
1314:
1295:
1269:
1250:
1219:
834:
820:
811:
804:
797:
782:
722:
720:Top expressed in
715:
688:caput epididymis
676:Brodmann area 23
668:secondary oocyte
660:
658:Top expressed in
653:
632:
615:
605:
592:
581:
566:
559:
553:
542:
530:
514:
504:
491:
480:
465:
458:
452:
441:
427:
411:
405:
356:
349:
326:
73:
67:
46:
45:
40:
28:
5811:
5810:
5806:
5805:
5804:
5802:
5801:
5800:
5791:Protein kinases
5776:
5775:
5774:
5762:
5754:
5752:
5747:
5659:Oxidoreductases
5645:
5621:Enzyme kinetics
5609:
5605:List of enzymes
5578:
5547:
5518:Catalytic triad
5496:
5491:
5461:
5448:
5396:
5374:
5298:
5281:
5264:
5247:
5218:
5078:
4978:
4949:P70-S6 Kinase 1
4919:
4810:
4772:
4750:
4716:
4692:
4653:
4619:
4325:
4296:
4272:
4253:
4174:
4150:
4111:
4067:
4050:
4026:
4020:Aurora C kinase
4015:Aurora B kinase
4010:Aurora A kinase
3990:
3971:
3937:
3908:
3841:
3807:
3663:
3649:
3635:
3605:
3600:
3597:
3591:
3582:
3576:
3567:
3561:
3552:
3546:
3537:
3531:
3522:
3516:
3507:
3501:
3492:
3486:
3477:
3471:
3462:
3456:
3447:
3441:
3432:
3426:
3417:
3411:
3397:
3394:
3352:
3347:
3308:
3278:(11): 1438–52.
3265:
3235:(11): 3024–33.
3222:
3171:
3132:
3093:
3064:
3013:
2974:
2946:(5351): 710–4.
2936:
2899:
2877:(3): 1496–505.
2864:
2855:
2808:
2803:
2781:(48): 30491–7.
2768:
2748:(1–2): 149–56.
2739:
2688:
2652:Mol. Cell. Biol
2645:
2594:
2565:
2526:
2522:
2520:Further reading
2517:
2494:(42): 39360–7.
2481:
2480:
2476:
2445:
2444:
2437:
2407:
2406:
2402:
2371:(11): 3024–33.
2358:
2357:
2350:
2306:
2305:
2301:
2265:
2264:
2253:
2223:
2222:
2213:
2190:(29): 27462–9.
2177:
2176:
2172:
2149:(15): 12874–8.
2136:
2135:
2131:
2089:
2088:
2084:
2040:
2039:
2035:
2005:
2004:
2000:
1956:
1955:
1951:
1942:
1941:
1937:
1924:
1923:
1919:
1906:
1905:
1901:
1889:
1880:
1868:
1859:
1855:
1850:
1780:
1738:
1654:
1604:
1557:View/Edit Mouse
1552:View/Edit Human
1515:
1508:
1505:Location (UCSC)
1491:
1487:
1483:
1462:
1458:
1454:
1428:
1424:
1420:
1399:
1395:
1391:
1304:ENSG00000140992
1197:
1013:phosphorylation
981:
947:plasma membrane
932:cell projection
910:
906:kinase activity
891:protein binding
816:
806:
805:
778:
769:
764:
760:
756:
752:
748:
744:
740:
736:
732:
718:
707:
704:visceral pleura
702:
698:
694:
690:
686:
682:
678:
674:
670:
656:
600:
587:
580:17|17 A3.3
579:
569:
568:
567:
560:
540:
517:Gene location (
499:
486:
478:
468:
467:
466:
459:
437:
414:Gene location (
365:
352:
345:
82:
60:
26:
17:
12:
11:
5:
5809:
5807:
5799:
5798:
5793:
5788:
5778:
5777:
5773:
5772:
5749:
5748:
5746:
5745:
5732:
5719:
5706:
5693:
5680:
5667:
5653:
5651:
5647:
5646:
5644:
5643:
5638:
5633:
5628:
5623:
5617:
5615:
5611:
5610:
5608:
5607:
5602:
5597:
5592:
5586:
5584:
5583:Classification
5580:
5579:
5577:
5576:
5571:
5566:
5561:
5555:
5553:
5549:
5548:
5546:
5545:
5540:
5535:
5530:
5525:
5520:
5515:
5510:
5504:
5502:
5498:
5497:
5492:
5490:
5489:
5482:
5475:
5467:
5458:
5457:
5454:
5453:
5450:
5449:
5447:
5446:
5441:
5436:
5431:
5426:
5421:
5416:
5410:
5408:
5398:
5397:
5391:
5384:
5383:
5380:
5379:
5376:
5375:
5373:
5372:
5367:
5362:
5357:
5352:
5347:
5342:
5337:
5336:
5335:
5330:
5325:
5320:
5309:
5307:
5306:(EC 2.7.11.30)
5300:
5299:
5297:
5296:
5292:
5290:
5289:(EC 2.7.11.29)
5283:
5282:
5280:
5279:
5275:
5273:
5272:(EC 2.7.11.28)
5266:
5265:
5263:
5262:
5258:
5256:
5255:(EC 2.7.11.27)
5249:
5248:
5246:
5245:
5240:
5235:
5229:
5227:
5226:(EC 2.7.11.26)
5220:
5219:
5217:
5216:
5211:
5206:
5205:
5204:
5199:
5194:
5189:
5184:
5179:
5174:
5164:
5163:
5162:
5157:
5152:
5147:
5137:
5136:
5135:
5130:
5125:
5120:
5115:
5110:
5105:
5100:
5089:
5087:
5086:(EC 2.7.11.25)
5080:
5079:
5077:
5076:
5075:
5074:
5069:
5064:
5054:
5053:
5052:
5047:
5042:
5032:
5031:
5030:
5025:
5020:
5015:
5010:
5005:
5000:
4989:
4987:
4986:(EC 2.7.11.24)
4980:
4979:
4977:
4976:
4971:
4966:
4961:
4956:
4951:
4946:
4941:
4936:
4930:
4928:
4927:(EC 2.7.11.23)
4921:
4920:
4918:
4917:
4912:
4907:
4902:
4897:
4892:
4887:
4882:
4877:
4872:
4867:
4862:
4857:
4852:
4847:
4842:
4837:
4832:
4827:
4821:
4819:
4818:(EC 2.7.11.22)
4812:
4811:
4809:
4808:
4803:
4798:
4793:
4787:
4785:
4784:(EC 2.7.11.21)
4774:
4773:
4767:
4760:
4759:
4756:
4755:
4752:
4751:
4749:
4748:
4743:
4738:
4733:
4727:
4725:
4724:(EC 2.7.11.21)
4718:
4717:
4715:
4714:
4709:
4703:
4701:
4700:(EC 2.7.11.20)
4694:
4693:
4691:
4690:
4685:
4680:
4675:
4670:
4664:
4662:
4661:(EC 2.7.11.19)
4655:
4654:
4652:
4651:
4646:
4641:
4636:
4630:
4628:
4627:(EC 2.7.11.18)
4621:
4620:
4618:
4617:
4612:
4607:
4602:
4597:
4592:
4587:
4582:
4577:
4572:
4567:
4562:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4497:
4492:
4487:
4482:
4477:
4472:
4467:
4462:
4457:
4452:
4447:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4387:
4382:
4377:
4372:
4367:
4362:
4357:
4352:
4347:
4342:
4336:
4334:
4333:(EC 2.7.11.17)
4327:
4326:
4324:
4323:
4318:
4313:
4307:
4305:
4304:(EC 2.7.11.16)
4298:
4297:
4295:
4294:
4289:
4283:
4281:
4280:(EC 2.7.11.15)
4274:
4273:
4271:
4270:
4264:
4262:
4261:(EC 2.7.11.14)
4255:
4254:
4252:
4251:
4246:
4241:
4236:
4231:
4226:
4221:
4216:
4211:
4206:
4201:
4196:
4191:
4185:
4183:
4182:(EC 2.7.11.13)
4176:
4175:
4173:
4172:
4167:
4161:
4159:
4158:(EC 2.7.11.12)
4152:
4151:
4149:
4148:
4143:
4138:
4133:
4128:
4122:
4120:
4119:(EC 2.7.11.11)
4113:
4112:
4110:
4109:
4104:
4099:
4094:
4089:
4084:
4078:
4076:
4075:(EC 2.7.11.10)
4069:
4068:
4066:
4065:
4061:
4059:
4052:
4051:
4049:
4048:
4043:
4037:
4035:
4028:
4027:
4025:
4024:
4023:
4022:
4017:
4012:
4001:
3999:
3992:
3991:
3989:
3988:
3982:
3980:
3973:
3972:
3970:
3969:
3964:
3959:
3954:
3948:
3946:
3939:
3938:
3936:
3935:
3930:
3925:
3919:
3917:
3910:
3909:
3907:
3906:
3905:
3904:
3899:
3894:
3886:
3885:
3884:
3879:
3871:
3870:
3869:
3864:
3852:
3850:
3843:
3842:
3840:
3839:
3834:
3829:
3824:
3818:
3816:
3809:
3808:
3806:
3805:
3804:
3803:
3793:
3792:
3791:
3786:
3781:
3776:
3766:
3761:
3756:
3755:
3754:
3749:
3744:
3734:
3729:
3724:
3719:
3714:
3709:
3704:
3699:
3694:
3689:
3684:
3678:
3676:
3665:
3664:
3658:
3651:
3650:
3636:
3634:
3633:
3626:
3619:
3611:
3602:
3601:
3599:
3598:
3592:
3585:
3583:
3577:
3570:
3568:
3562:
3555:
3553:
3547:
3540:
3538:
3532:
3525:
3523:
3517:
3510:
3508:
3502:
3495:
3493:
3487:
3480:
3478:
3472:
3465:
3463:
3457:
3450:
3448:
3442:
3435:
3433:
3427:
3420:
3418:
3412:
3405:
3402:
3399:
3398:
3395:
3393:
3392:
3385:
3378:
3370:
3364:
3363:
3351:
3350:External links
3348:
3346:
3345:
3306:
3263:
3220:
3184:(8): 393–404.
3169:
3130:
3091:
3062:
3026:(12): 684–91.
3011:
2972:
2934:
2897:
2862:
2801:
2766:
2737:
2701:(10): 776–89.
2686:
2658:(9): 5648–55.
2643:
2592:
2574:(1–2): 171–4.
2563:
2523:
2521:
2518:
2516:
2515:
2474:
2435:
2400:
2348:
2299:
2251:
2211:
2170:
2129:
2102:(5): 556–569.
2082:
2033:
1998:
1969:(34): 4330–9.
1949:
1935:
1917:
1899:
1878:
1856:
1854:
1851:
1849:
1848:
1843:
1837:
1831:
1825:
1819:
1813:
1807:
1801:
1795:
1788:
1779:
1776:
1737:
1734:
1653:
1650:
1603:
1600:
1576:refers to the
1564:
1563:
1560:
1559:
1554:
1544:
1543:
1537:
1536:
1533:
1532:
1530:
1528:
1521:
1520:
1513:
1506:
1502:
1501:
1498:
1497:
1479:
1478:
1472:
1469:
1468:
1450:
1449:
1443:
1439:
1438:
1435:
1434:
1416:
1415:
1409:
1406:
1405:
1387:
1386:
1380:
1376:
1375:
1372:
1371:
1363:
1362:
1356:
1353:
1352:
1344:
1343:
1337:
1331:
1330:
1327:
1326:
1318:
1317:
1311:
1308:
1307:
1299:
1298:
1292:
1286:
1285:
1282:
1281:
1273:
1272:
1266:
1263:
1262:
1254:
1253:
1247:
1241:
1240:
1235:
1230:
1226:
1225:
1215:
1214:
1211:
1210:
1199:
1198:
1196:
1195:
1190:
1185:
1180:
1175:
1170:
1165:
1160:
1155:
1150:
1145:
1140:
1135:
1130:
1128:cell migration
1125:
1120:
1115:
1110:
1105:
1100:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
989:
987:
983:
982:
980:
979:
974:
969:
964:
959:
954:
949:
944:
942:focal adhesion
939:
934:
929:
924:
918:
916:
912:
911:
909:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
847:
845:
841:
840:
830:
829:
826:
825:
822:
821:
813:
812:
794:
788:
787:
784:
783:
775:
774:
771:
770:
768:
767:
763:
759:
755:
751:
750:pontine nuclei
747:
743:
739:
735:
731:
727:
724:
723:
712:
709:
708:
706:
705:
701:
697:
693:
689:
685:
681:
677:
673:
669:
665:
662:
661:
649:
648:
640:
629:
623:
622:
619:RNA expression
611:
610:
607:
606:
598:
594:
593:
585:
582:
577:
571:
570:
561:
554:
548:
544:
543:
538:
532:
531:
523:
522:
510:
509:
506:
505:
497:
493:
492:
484:
481:
476:
470:
469:
460:
453:
447:
443:
442:
435:
429:
428:
420:
419:
407:
406:
363:
359:
358:
350:
342:
341:
337:
336:
333:
332:
329:
328:
78:
77:
69:
68:
57:
51:
50:
42:
41:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
5808:
5797:
5794:
5792:
5789:
5787:
5784:
5783:
5781:
5771:
5766:
5761:
5757:
5743:
5739:
5738:
5733:
5730:
5726:
5725:
5720:
5717:
5713:
5712:
5707:
5704:
5700:
5699:
5694:
5691:
5687:
5686:
5681:
5678:
5674:
5673:
5668:
5665:
5661:
5660:
5655:
5654:
5652:
5648:
5642:
5639:
5637:
5634:
5632:
5629:
5627:
5624:
5622:
5619:
5618:
5616:
5612:
5606:
5603:
5601:
5600:Enzyme family
5598:
5596:
5593:
5591:
5588:
5587:
5585:
5581:
5575:
5572:
5570:
5567:
5565:
5564:Cooperativity
5562:
5560:
5557:
5556:
5554:
5550:
5544:
5541:
5539:
5536:
5534:
5531:
5529:
5526:
5524:
5523:Oxyanion hole
5521:
5519:
5516:
5514:
5511:
5509:
5506:
5505:
5503:
5499:
5495:
5488:
5483:
5481:
5476:
5474:
5469:
5468:
5465:
5445:
5442:
5440:
5437:
5435:
5432:
5430:
5427:
5425:
5422:
5420:
5417:
5415:
5412:
5411:
5409:
5407:
5403:
5399:
5394:
5389:
5385:
5371:
5368:
5366:
5363:
5361:
5358:
5356:
5353:
5351:
5348:
5346:
5343:
5341:
5338:
5334:
5331:
5329:
5326:
5324:
5321:
5319:
5316:
5315:
5314:
5311:
5310:
5308:
5305:
5301:
5294:
5293:
5291:
5288:
5284:
5277:
5276:
5274:
5271:
5267:
5260:
5259:
5257:
5254:
5250:
5244:
5241:
5239:
5236:
5234:
5231:
5230:
5228:
5225:
5221:
5215:
5212:
5210:
5207:
5203:
5200:
5198:
5195:
5193:
5190:
5188:
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5169:
5168:
5165:
5161:
5158:
5156:
5153:
5151:
5148:
5146:
5143:
5142:
5141:
5138:
5134:
5131:
5129:
5126:
5124:
5121:
5119:
5116:
5114:
5111:
5109:
5106:
5104:
5101:
5099:
5096:
5095:
5094:
5091:
5090:
5088:
5085:
5081:
5073:
5070:
5068:
5065:
5063:
5060:
5059:
5058:
5055:
5051:
5048:
5046:
5043:
5041:
5038:
5037:
5036:
5033:
5029:
5026:
5024:
5021:
5019:
5016:
5014:
5011:
5009:
5006:
5004:
5001:
4999:
4996:
4995:
4994:
4991:
4990:
4988:
4985:
4981:
4975:
4972:
4970:
4967:
4965:
4962:
4960:
4957:
4955:
4952:
4950:
4947:
4945:
4942:
4940:
4937:
4935:
4932:
4931:
4929:
4926:
4922:
4916:
4913:
4911:
4908:
4906:
4903:
4901:
4898:
4896:
4893:
4891:
4888:
4886:
4883:
4881:
4878:
4876:
4873:
4871:
4868:
4866:
4863:
4861:
4858:
4856:
4853:
4851:
4848:
4846:
4843:
4841:
4838:
4836:
4833:
4831:
4828:
4826:
4823:
4822:
4820:
4817:
4813:
4807:
4804:
4802:
4799:
4797:
4794:
4792:
4789:
4788:
4786:
4783:
4779:
4775:
4770:
4765:
4761:
4747:
4744:
4742:
4739:
4737:
4734:
4732:
4729:
4728:
4726:
4723:
4719:
4713:
4710:
4708:
4705:
4704:
4702:
4699:
4695:
4689:
4686:
4684:
4681:
4679:
4676:
4674:
4671:
4669:
4666:
4665:
4663:
4660:
4656:
4650:
4647:
4645:
4642:
4640:
4637:
4635:
4632:
4631:
4629:
4626:
4622:
4616:
4613:
4611:
4608:
4606:
4603:
4601:
4598:
4596:
4593:
4591:
4588:
4586:
4583:
4581:
4578:
4576:
4573:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4386:
4383:
4381:
4378:
4376:
4373:
4371:
4368:
4366:
4363:
4361:
4358:
4356:
4353:
4351:
4348:
4346:
4343:
4341:
4338:
4337:
4335:
4332:
4328:
4322:
4319:
4317:
4314:
4312:
4309:
4308:
4306:
4303:
4299:
4293:
4290:
4288:
4285:
4284:
4282:
4279:
4275:
4269:
4266:
4265:
4263:
4260:
4256:
4250:
4247:
4245:
4242:
4240:
4237:
4235:
4232:
4230:
4227:
4225:
4222:
4220:
4217:
4215:
4212:
4210:
4207:
4205:
4202:
4200:
4197:
4195:
4192:
4190:
4187:
4186:
4184:
4181:
4177:
4171:
4168:
4166:
4163:
4162:
4160:
4157:
4153:
4147:
4144:
4142:
4139:
4137:
4134:
4132:
4129:
4127:
4124:
4123:
4121:
4118:
4114:
4108:
4105:
4103:
4100:
4098:
4095:
4093:
4090:
4088:
4085:
4083:
4080:
4079:
4077:
4074:
4070:
4063:
4062:
4060:
4058:(EC 2.7.11.9)
4057:
4053:
4047:
4044:
4042:
4039:
4038:
4036:
4034:(EC 2.7.11.8)
4033:
4029:
4021:
4018:
4016:
4013:
4011:
4008:
4007:
4006:
4005:Aurora kinase
4003:
4002:
4000:
3998:(EC 2.7.11.7)
3997:
3993:
3987:
3984:
3983:
3981:
3979:(EC 2.7.11.6)
3978:
3974:
3968:
3965:
3963:
3960:
3958:
3955:
3953:
3950:
3949:
3947:
3945:(EC 2.7.11.5)
3944:
3940:
3934:
3931:
3929:
3926:
3924:
3921:
3920:
3918:
3916:(EC 2.7.11.4)
3915:
3911:
3903:
3900:
3898:
3895:
3893:
3890:
3889:
3887:
3883:
3880:
3878:
3875:
3874:
3872:
3868:
3865:
3863:
3860:
3859:
3857:
3854:
3853:
3851:
3849:(EC 2.7.11.3)
3848:
3844:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3819:
3817:
3815:(EC 2.7.11.2)
3814:
3810:
3802:
3799:
3798:
3797:
3794:
3790:
3787:
3785:
3782:
3780:
3777:
3775:
3772:
3771:
3770:
3769:EIF-2 kinases
3767:
3765:
3762:
3760:
3757:
3753:
3750:
3748:
3745:
3743:
3740:
3739:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3700:
3698:
3695:
3693:
3690:
3688:
3685:
3683:
3680:
3679:
3677:
3675:(EC 2.7.11.1)
3674:
3670:
3666:
3661:
3656:
3652:
3647:
3643:
3639:
3632:
3627:
3625:
3620:
3618:
3613:
3612:
3609:
3595:
3589:
3584:
3580:
3574:
3569:
3565:
3559:
3554:
3550:
3544:
3539:
3535:
3529:
3524:
3520:
3514:
3509:
3505:
3499:
3494:
3490:
3484:
3479:
3475:
3469:
3464:
3460:
3454:
3449:
3445:
3439:
3434:
3430:
3424:
3419:
3415:
3409:
3404:
3400:
3391:
3386:
3384:
3379:
3377:
3372:
3371:
3368:
3361:
3357:
3354:
3353:
3349:
3342:
3338:
3333:
3328:
3324:
3320:
3316:
3312:
3307:
3303:
3299:
3294:
3289:
3285:
3281:
3277:
3273:
3269:
3264:
3260:
3256:
3251:
3246:
3242:
3238:
3234:
3230:
3226:
3221:
3217:
3213:
3209:
3205:
3200:
3195:
3191:
3187:
3183:
3179:
3175:
3170:
3166:
3162:
3157:
3152:
3148:
3144:
3140:
3136:
3131:
3127:
3123:
3118:
3113:
3109:
3105:
3101:
3097:
3092:
3088:
3084:
3080:
3076:
3072:
3068:
3063:
3059:
3055:
3051:
3047:
3042:
3037:
3033:
3029:
3025:
3021:
3017:
3012:
3008:
3004:
2999:
2994:
2990:
2986:
2982:
2978:
2973:
2969:
2965:
2961:
2957:
2953:
2949:
2945:
2941:
2935:
2931:
2927:
2923:
2919:
2915:
2911:
2907:
2903:
2898:
2894:
2890:
2885:
2880:
2876:
2872:
2871:J. Biol. Chem
2868:
2863:
2859:
2852:
2848:
2844:
2840:
2835:
2830:
2826:
2822:
2818:
2814:
2807:
2802:
2798:
2794:
2789:
2784:
2780:
2776:
2775:J. Biol. Chem
2772:
2767:
2763:
2759:
2755:
2751:
2747:
2743:
2738:
2734:
2730:
2726:
2722:
2717:
2712:
2708:
2704:
2700:
2696:
2692:
2687:
2683:
2679:
2674:
2669:
2665:
2661:
2657:
2653:
2649:
2644:
2640:
2636:
2632:
2628:
2623:
2618:
2614:
2610:
2606:
2602:
2598:
2593:
2589:
2585:
2581:
2577:
2573:
2569:
2564:
2560:
2556:
2551:
2546:
2542:
2538:
2534:
2530:
2525:
2524:
2519:
2511:
2507:
2502:
2497:
2493:
2489:
2488:J. Biol. Chem
2485:
2478:
2475:
2470:
2466:
2462:
2458:
2455:(2): 207–15.
2454:
2450:
2442:
2440:
2436:
2431:
2427:
2423:
2419:
2415:
2411:
2404:
2401:
2396:
2392:
2387:
2382:
2378:
2374:
2370:
2366:
2362:
2355:
2353:
2349:
2344:
2340:
2335:
2330:
2326:
2322:
2319:(5): 979–88.
2318:
2314:
2310:
2303:
2300:
2295:
2291:
2286:
2281:
2277:
2273:
2272:J. Biol. Chem
2269:
2262:
2260:
2258:
2256:
2252:
2247:
2243:
2239:
2235:
2231:
2227:
2220:
2218:
2216:
2212:
2207:
2203:
2198:
2193:
2189:
2185:
2184:J. Biol. Chem
2181:
2174:
2171:
2166:
2162:
2157:
2152:
2148:
2144:
2143:J. Biol. Chem
2140:
2133:
2130:
2125:
2121:
2117:
2113:
2109:
2105:
2101:
2097:
2096:Nature Plants
2093:
2086:
2083:
2078:
2074:
2069:
2064:
2060:
2056:
2052:
2048:
2044:
2037:
2034:
2029:
2025:
2021:
2017:
2014:(2): 161–70.
2013:
2009:
2002:
1999:
1994:
1990:
1985:
1980:
1976:
1972:
1968:
1964:
1960:
1953:
1950:
1945:
1939:
1936:
1931:
1927:
1921:
1918:
1913:
1909:
1903:
1900:
1896:
1892:
1887:
1885:
1883:
1879:
1875:
1871:
1866:
1864:
1862:
1858:
1852:
1847:
1844:
1841:
1838:
1835:
1832:
1829:
1826:
1823:
1820:
1817:
1814:
1811:
1808:
1805:
1802:
1799:
1796:
1793:
1790:
1789:
1787:
1785:
1777:
1775:
1772:
1770:
1766:
1761:
1759:
1755:
1751:
1747:
1743:
1735:
1733:
1731:
1727:
1723:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1693:
1689:
1685:
1684:
1679:
1678:
1673:
1672:
1667:
1666:
1661:
1660:
1651:
1649:
1645:
1643:
1638:
1635:
1633:
1629:
1625:
1621:
1617:
1613:
1609:
1601:
1599:
1597:
1593:
1590:
1586:
1582:
1579:
1575:
1571:
1558:
1553:
1549:
1545:
1542:
1538:
1531:
1529:
1526:
1522:
1518:
1514:
1511:
1507:
1503:
1496:
1494:
1490:
1486:
1480:
1476:
1473:
1467:
1465:
1461:
1457:
1451:
1447:
1444:
1440:
1433:
1431:
1427:
1423:
1417:
1413:
1410:
1404:
1402:
1398:
1394:
1388:
1384:
1381:
1379:RefSeq (mRNA)
1377:
1370:
1369:
1364:
1360:
1357:
1351:
1350:
1345:
1341:
1338:
1336:
1332:
1325:
1324:
1319:
1315:
1312:
1306:
1305:
1300:
1296:
1293:
1291:
1287:
1280:
1279:
1274:
1270:
1267:
1261:
1260:
1255:
1251:
1248:
1246:
1242:
1239:
1236:
1234:
1231:
1227:
1224:
1220:
1216:
1209:
1205:
1200:
1194:
1191:
1189:
1186:
1184:
1181:
1179:
1176:
1174:
1171:
1169:
1166:
1164:
1161:
1159:
1156:
1154:
1151:
1149:
1146:
1144:
1141:
1139:
1136:
1134:
1131:
1129:
1126:
1124:
1121:
1119:
1116:
1114:
1111:
1109:
1106:
1104:
1101:
1099:
1096:
1094:
1091:
1089:
1086:
1084:
1081:
1079:
1076:
1074:
1071:
1069:
1066:
1064:
1061:
1059:
1056:
1054:
1051:
1049:
1046:
1044:
1041:
1039:
1036:
1034:
1031:
1029:
1026:
1024:
1021:
1019:
1016:
1014:
1011:
1009:
1006:
1004:
1001:
999:
996:
994:
991:
990:
988:
985:
984:
978:
975:
973:
970:
968:
965:
963:
960:
958:
957:cell junction
955:
953:
950:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
923:
920:
919:
917:
914:
913:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
848:
846:
843:
842:
839:
838:Gene ontology
835:
831:
819:
814:
810:
803:
798:
795:
793:
789:
781:
776:
765:
761:
757:
753:
749:
745:
741:
737:
733:
729:
728:
725:
721:
716:
713:
703:
699:
695:
691:
687:
684:parotid gland
683:
679:
675:
671:
667:
666:
663:
659:
654:
651:
650:
647:
645:
641:
639:
638:
634:
633:
630:
628:
624:
620:
616:
612:
604:
599:
595:
591:
586:
576:
572:
565:
558:
552:
545:
537:
533:
529:
524:
520:
515:
511:
503:
498:
494:
490:
485:
475:
471:
464:
457:
451:
444:
440:
434:
430:
426:
421:
417:
412:
408:
404:
400:
396:
392:
388:
384:
380:
376:
372:
368:
360:
355:
348:
343:
338:
327:
325:
321:
317:
313:
309:
305:
301:
297:
293:
289:
285:
281:
277:
273:
269:
265:
261:
257:
253:
249:
245:
241:
237:
233:
229:
225:
221:
217:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
79:
74:
71:
70:
66:
63:
56:
52:
47:
43:
39:
34:
29:
24:
19:
5737:Translocases
5734:
5721:
5708:
5695:
5682:
5672:Transferases
5669:
5656:
5513:Binding site
4944:P70S6 kinase
3593:
3578:
3563:
3548:
3533:
3518:
3503:
3488:
3473:
3458:
3443:
3428:
3413:
3314:
3275:
3271:
3232:
3228:
3181:
3177:
3138:
3099:
3070:
3066:
3023:
3019:
2980:
2943:
2939:
2905:
2901:
2874:
2870:
2819:(2): 69–81.
2816:
2812:
2778:
2774:
2745:
2741:
2698:
2694:
2655:
2651:
2607:(4): 261–9.
2604:
2600:
2571:
2567:
2532:
2491:
2487:
2477:
2452:
2448:
2413:
2409:
2403:
2368:
2364:
2316:
2312:
2302:
2275:
2271:
2232:(2): 561–9.
2229:
2226:Biochemistry
2225:
2187:
2183:
2173:
2146:
2142:
2132:
2099:
2095:
2085:
2050:
2046:
2036:
2011:
2007:
2001:
1966:
1962:
1952:
1938:
1929:
1920:
1911:
1902:
1781:
1778:Interactions
1773:
1762:
1739:
1724:
1682:
1681:
1676:
1675:
1670:
1669:
1664:
1663:
1658:
1657:
1655:
1646:
1642:PI3K pathway
1639:
1636:
1605:
1588:
1580:
1573:
1570:biochemistry
1567:
1489:NP_001273591
1485:NP_001074242
1482:
1456:NP_001248745
1453:
1426:NM_001286662
1422:NM_001080773
1419:
1393:NM_001261816
1390:
1366:
1347:
1321:
1302:
1276:
1257:
1237:
1232:
642:
635:
362:External IDs
81:
18:
5508:Active site
5395:(EC 2.7.12)
4782:Polo kinase
4722:Polo kinase
3396:PDB gallery
1644:(PTEN+/-).
1634:signaling.
1616:AGC kinases
952:nucleoplasm
896:ATP binding
601:24,369,898
588:24,292,654
340:Identifiers
5780:Categories
5711:Isomerases
5685:Hydrolases
5552:Regulation
4073:IκB kinase
3648:2.7.11-12)
3315:Biochem. J
3178:Curr. Biol
3139:Biochem. J
3100:Biochem. J
3020:Curr. Biol
2981:Biochem. J
2813:Curr. Biol
2695:Curr. Biol
2601:Curr. Biol
2533:Biochem. J
1897:, May 2017
1876:, May 2017
1853:References
1618:including
967:perikaryon
646:(ortholog)
500:2,603,188
487:2,537,979
383:HomoloGene
5796:EC 2.7.11
5590:EC number
4199:PKC alpha
3272:Genes Dev
2124:218593545
1746:PH domain
1742:PH domain
1736:Structure
1668:ependent
1652:Etymology
1596:melanomas
1493:NP_035192
1464:NP_112558
1460:NP_002604
1430:NM_011062
1401:NM_031268
1397:NM_002613
1223:Orthologs
922:cytoplasm
391:GeneCards
5614:Kinetics
5538:Cofactor
5501:Activity
4555:KIAA0999
4450:MAPKAPK5
4445:MAPKAPK3
4440:MAPKAPK2
3341:10455013
3302:10364160
3259:10357815
3216:16473977
3208:10226025
3165:10191262
3058:13936854
2851:18688785
2559:10698680
2510:12177059
2469:12387817
2395:10357815
2343:10698939
2294:10764742
2246:11781095
2206:11313365
2165:11825911
2116:32393881
2077:12374740
2028:15209375
1993:24037523
1963:Oncogene
1893:–
1872:–
1840:SLC9A3R2
1784:interact
1602:Function
1541:Wikidata
1202:Sources:
937:membrane
5770:Biology
5724:Ligases
5494:Enzymes
5214:MAP3K14
5192:MAP3K11
5187:MAP3K10
5177:MAP3K13
5172:MAP3K12
4974:RPS6KC1
4969:RPS6KA1
4964:RPS6KA3
4959:RPS6KA2
4954:RPS6KB2
4939:RPS6KA4
4934:RPS6KA5
4585:Kalirin
4550:SNF1LK2
3789:EIF2AK4
3784:EIF2AK3
3638:Kinases
3332:1220463
3250:1171384
3186:Bibcode
3156:1220160
3126:9895304
3117:1220012
3087:9748166
3067:Science
3050:9637919
3028:Bibcode
3007:9512493
2998:1219352
2968:9445477
2948:Bibcode
2940:Science
2930:9445476
2910:Bibcode
2902:Science
2893:9430688
2843:9427642
2821:Bibcode
2797:9374542
2762:9373149
2733:1167390
2725:9368760
2703:Bibcode
2682:9271440
2639:2094414
2631:9094314
2609:Bibcode
2588:8125298
2550:1220886
2430:9748166
2410:Science
2386:1171384
1984:3955742
1895:Ensembl
1874:Ensembl
1674:rotein
1632:insulin
1578:protein
1335:UniProt
1290:Ensembl
1229:Species
1208:QuickGO
962:nucleus
927:cytosol
621:pattern
479:16p13.3
379:1338068
347:Aliases
25:(PDK1).
5756:Portal
5698:Lyases
5444:MAP2K7
5439:MAP2K6
5434:MAP2K5
5429:MAP2K4
5424:MAP2K3
5419:MAP2K2
5414:MAP2K1
5365:ACVRL1
5360:ACVR2B
5355:ACVR2A
5350:ACVR1C
5345:ACVR1B
5328:BMPR1B
5323:BMPR1A
5197:MAP3K7
5182:MAP3K9
5133:MAP3K8
5128:MAP3K7
5123:MAP3K6
5118:MAP3K5
5113:MAP3K4
5108:MAP3K3
5103:MAP3K2
5098:MAP3K1
5072:MAPK14
5067:MAPK13
5062:MAPK11
5050:MAPK10
5028:MAPK15
5023:MAPK12
4915:CDC2L1
4890:CDC2L5
4565:SNF1LK
4390:CAMK2G
4385:CAMK2D
4380:CAMK2B
4375:CAMK2A
4365:CAMK1G
4360:CAMK1D
4355:CAMK1B
4350:CAMK1A
4204:PRKCB1
4141:PRKACA
4136:PRKACB
4131:PRKACG
4107:IKBKAP
3933:BCKDHB
3928:BCKDHA
3902:PRKAG3
3897:PRKAG2
3892:PRKAG1
3882:PRKAB2
3877:PRKAB1
3867:PRKAA2
3862:PRKAA1
3707:STK38L
3362:(MeSH)
3339:
3329:
3300:
3293:316759
3290:
3257:
3247:
3229:EMBO J
3214:
3206:
3163:
3153:
3124:
3114:
3085:
3056:
3048:
3005:
2995:
2966:
2928:
2891:
2849:
2841:
2795:
2760:
2731:
2723:
2680:
2673:232413
2670:
2637:
2629:
2586:
2557:
2547:
2508:
2467:
2428:
2393:
2383:
2365:EMBO J
2341:
2334:305637
2331:
2313:EMBO J
2292:
2244:
2204:
2163:
2122:
2114:
2075:
2068:129083
2065:
2047:EMBO J
2026:
1991:
1981:
1842:, and
1804:PRKACA
1786:with:
1765:ligand
1744:. The
1680:inase
1608:kinase
1585:enzyme
1527:search
1525:PubMed
1368:Q9Z2A0
1349:O15530
1245:Entrez
792:BioGPS
746:zygote
371:605213
5650:Types
5406:MAP2K
5340:ACVR1
5333:BMPR2
5318:BMPR1
5243:GSK-3
5084:MAP3K
5045:MAPK9
5040:MAPK8
5018:MAPK7
5013:MAPK6
5008:MAPK4
5003:MAPK3
4998:MAPK1
4910:PFTK1
4905:PCTK3
4900:PCTK2
4895:PCTK1
4885:CDK12
4880:CDK10
4855:CDKL5
4835:CDKL2
4712:STK19
4707:EEF2K
4688:PHKG2
4683:PHKG1
4673:PHKA2
4668:PHKA1
4649:MYLK4
4644:MYLK3
4639:MYLK2
4615:DCLK1
4610:Titin
4600:TRIB3
4595:TRIB2
4590:TRIB1
4580:TSSK2
4560:STK40
4545:PSKH1
4540:PRKD3
4535:PRKD2
4515:PHKG2
4510:PHKG1
4500:OBSCN
4495:NUAK2
4490:NUAK1
4485:MKNK2
4480:MKNK1
4470:MARK4
4465:MARK3
4460:MARK2
4455:MARK1
4435:STK11
4430:DAPK3
4425:DAPK2
4420:DAPK1
4415:CHEK2
4410:CHEK1
4395:CAMK4
4370:CAMK2
4345:CAMK1
4340:BRSK2
4234:PRKCQ
4229:PRKCI
4224:PRKCG
4219:PRKCH
4214:PRKCE
4209:PRKCD
4170:PRKG1
4102:IKBKG
4097:IKBKE
4046:STK10
4041:FASTK
3967:IDH3G
3962:IDH3B
3957:IDH3A
3923:BCKDK
3717:ROCK1
3702:STK38
3697:MAST2
3692:MAST1
3687:LATS2
3682:LATS1
3212:S2CID
3054:S2CID
2847:S2CID
2809:(PDF)
2729:S2CID
2635:S2CID
2120:S2CID
1846:YWHAH
1816:PRKCI
1810:PRKCD
1589:PDPK1
1583:, an
1574:PDPK1
1278:18607
1238:Mouse
1233:Human
1204:Amigo
644:Mouse
637:Human
584:Start
519:Mouse
483:Start
416:Human
395:PDPK1
387:37643
354:PDPK1
31:PDPK1
5742:list
5735:EC7
5729:list
5722:EC6
5716:list
5709:EC5
5703:list
5696:EC4
5690:list
5683:EC3
5677:list
5670:EC2
5664:list
5657:EC1
5233:TPK1
5209:CDC7
5167:MLKs
5160:KSR2
5155:KSR1
5150:BRAF
5145:ARAF
5140:RAFs
4875:CDK9
4870:CDK8
4865:CDK7
4860:CDK6
4850:CDK5
4845:CDK4
4840:CDK3
4830:CDK2
4825:CDK1
4806:PLK4
4801:PLK3
4796:PLK2
4791:PLK1
4746:PLK4
4741:PLK3
4736:PLK2
4731:PLK1
4678:PHKB
4634:MYLK
4605:TRIO
4575:SPEG
4570:SNRK
4530:PKD1
4525:PIM2
4520:PIM1
4505:PASK
4475:MELK
4405:CASK
4400:MLCK
4321:GRK6
4316:GRK5
4311:GRK4
4249:PKN3
4244:PKN2
4146:PRKY
4092:TBK1
4087:IKK2
4082:CHUK
3986:STK4
3952:IDH2
3837:PDK4
3832:PDK3
3827:PDK2
3822:PDK1
3801:WEE1
3796:Wee1
3764:mTOR
3752:AKT3
3747:AKT2
3742:AKT1
3732:SGK3
3727:SGK2
3594:2biy
3579:1z5m
3564:1w1h
3549:1w1g
3534:1w1d
3519:1uvr
3504:1uu9
3489:1uu8
3474:1uu7
3459:1uu3
3444:1okz
3429:1oky
3414:1h1w
3337:PMID
3298:PMID
3255:PMID
3204:PMID
3161:PMID
3122:PMID
3083:PMID
3046:PMID
3003:PMID
2964:PMID
2926:PMID
2889:PMID
2839:PMID
2793:PMID
2758:PMID
2742:Gene
2721:PMID
2678:PMID
2627:PMID
2584:PMID
2568:Gene
2555:PMID
2506:PMID
2465:PMID
2426:PMID
2391:PMID
2339:PMID
2290:PMID
2242:PMID
2202:PMID
2161:PMID
2112:PMID
2073:PMID
2024:PMID
1989:PMID
1798:PKN2
1792:AKT1
1752:and
1714:and
1704:PI3K
1698:and
1688:PI3K
1592:gene
1259:5170
627:Bgee
575:Band
536:Chr.
474:Band
433:Chr.
367:OMIM
324:5HNG
320:5HKM
316:5HO8
312:5HO7
308:5ACK
304:4XX9
300:4RRV
296:4RQV
292:4CT2
288:4CT1
284:4AW1
280:4AW0
276:4A07
272:4A06
268:3SC1
264:3RWQ
260:3RWP
256:3RCJ
252:3QD4
248:3QD3
244:3QD0
240:3QCY
236:3QCX
232:3QCS
228:3QCQ
224:3QC4
220:3PWY
216:3OTU
212:3ORZ
208:3ORX
204:3NUY
200:3NUU
196:3NUS
192:3NUN
188:3NAY
184:3NAX
180:3IOP
176:3ION
172:3HRF
168:3HRC
164:3H9O
160:2XCK
156:2XCH
152:2VKI
148:2R7B
144:2PE2
140:2PE1
136:2PE0
132:2BIY
128:1Z5M
124:1W1H
120:1W1G
116:1W1D
112:1UVR
108:1UU9
104:1UU8
100:1UU7
96:1UU3
92:1OKZ
88:1OKY
84:1H1W
65:RCSB
62:PDBe
5238:TTK
5202:ZAK
3779:HRI
3774:PKR
3722:SGK
3712:CIT
3327:PMC
3319:doi
3288:PMC
3280:doi
3245:PMC
3237:doi
3194:doi
3151:PMC
3143:doi
3112:PMC
3104:doi
3075:doi
3071:281
3036:doi
2993:PMC
2985:doi
2956:doi
2944:279
2918:doi
2906:279
2879:doi
2875:273
2829:doi
2783:doi
2779:272
2750:doi
2746:200
2711:doi
2668:PMC
2660:doi
2617:doi
2576:doi
2572:138
2545:PMC
2537:doi
2496:doi
2492:277
2457:doi
2453:298
2418:doi
2414:281
2381:PMC
2373:doi
2329:PMC
2321:doi
2280:doi
2276:275
2234:doi
2192:doi
2188:276
2151:doi
2147:277
2104:doi
2063:PMC
2055:doi
2016:doi
1979:PMC
1971:doi
1834:SGK
1758:AKT
1730:AKT
1628:SGK
1624:S6K
1620:PKC
1612:AKT
597:End
496:End
399:OMA
375:MGI
55:PDB
5782::
3888:γ
3873:β
3858:α
3646:EC
3640::
3335:.
3325:.
3313:.
3296:.
3286:.
3276:13
3274:.
3270:.
3253:.
3243:.
3233:18
3231:.
3227:.
3210:.
3202:.
3192:.
3180:.
3176:.
3159:.
3149:.
3137:.
3120:.
3110:.
3098:.
3081:.
3069:.
3052:.
3044:.
3034:.
3022:.
3018:.
3001:.
2991:.
2979:.
2962:.
2954:.
2942:.
2924:.
2916:.
2904:.
2887:.
2873:.
2869:.
2845:.
2837:.
2827:.
2815:.
2811:.
2791:.
2777:.
2773:.
2756:.
2744:.
2727:.
2719:.
2709:.
2697:.
2693:.
2676:.
2666:.
2656:17
2654:.
2650:.
2633:.
2625:.
2615:.
2603:.
2599:.
2582:.
2570:.
2553:.
2543:.
2531:.
2504:.
2490:.
2486:.
2463:.
2451:.
2438:^
2424:.
2412:.
2389:.
2379:.
2369:18
2367:.
2363:.
2351:^
2337:.
2327:.
2317:19
2315:.
2311:.
2288:.
2274:.
2270:.
2254:^
2240:.
2230:41
2228:.
2214:^
2200:.
2186:.
2182:.
2159:.
2145:.
2141:.
2118:.
2110:.
2098:.
2094:.
2071:.
2061:.
2051:21
2049:.
2045:.
2022:.
2012:15
2010:.
1987:.
1977:.
1967:33
1965:.
1961:.
1928:.
1910:.
1881:^
1860:^
1760:.
1702:.
1694:,
1626:,
1622:,
1598:.
1572:,
1206:/
603:bp
590:bp
502:bp
489:bp
397:;
393::
389:;
385::
381:;
377::
373:;
369::
322:,
318:,
314:,
310:,
306:,
302:,
298:,
294:,
290:,
286:,
282:,
278:,
274:,
270:,
266:,
262:,
258:,
254:,
250:,
246:,
242:,
238:,
234:,
230:,
226:,
222:,
218:,
214:,
210:,
206:,
202:,
198:,
194:,
190:,
186:,
182:,
178:,
174:,
170:,
166:,
162:,
158:,
154:,
150:,
146:,
142:,
138:,
134:,
130:,
126:,
122:,
118:,
114:,
110:,
106:,
102:,
98:,
94:,
90:,
86:,
5758::
5744:)
5740:(
5731:)
5727:(
5718:)
5714:(
5705:)
5701:(
5692:)
5688:(
5679:)
5675:(
5666:)
5662:(
5486:e
5479:t
5472:v
5295:-
5278:-
5261:-
4064:-
3644:(
3630:e
3623:t
3616:v
3389:e
3382:t
3375:v
3343:.
3321::
3304:.
3282::
3261:.
3239::
3218:.
3196::
3188::
3182:9
3167:.
3145::
3128:.
3106::
3089:.
3077::
3060:.
3038::
3030::
3024:8
3009:.
2987::
2970:.
2958::
2950::
2932:.
2920::
2912::
2895:.
2881::
2853:.
2831::
2823::
2817:8
2799:.
2785::
2764:.
2752::
2735:.
2713::
2705::
2699:7
2684:.
2662::
2641:.
2619::
2611::
2605:7
2590:.
2578::
2561:.
2539::
2512:.
2498::
2471:.
2459::
2432:.
2420::
2397:.
2375::
2345:.
2323::
2296:.
2282::
2248:.
2236::
2208:.
2194::
2167:.
2153::
2126:.
2106::
2100:6
2079:.
2057::
2030:.
2018::
1995:.
1973::
1946:.
1932:.
1914:.
1836:,
1830:,
1824:,
1818:,
1812:,
1806:,
1800:,
1794:,
1683:1
1677:k
1671:p
1665:d
1659:p
521:)
418:)
401::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
