828:. This hypothesis argues that when people have to make complex uncertain decisions, they employ both cognitive and emotional processes to assess the values of the choices available to them. Each time a person makes a decision, both physiological signals and evoked emotion (somatic markers) are associated with their outcomes, and this accumulates as experience. People tend to choose the choice which might produce the outcome reinforced with positive stimuli; thus it biases decision-making towards certain behaviors while avoiding others. It is thought that somatic markers are processed in the orbitofrontal cortex.
514:. It has been determined that there is a direct relationship between the type of tau mutation and the neuropathology of gene mutations. The mutations at the splice junction of exon 10 of tau lead to the selective deposition of the repetitive tau in neurons and glia. The pathological phenotype associated with mutations elsewhere in tau is less predictable, with both typical neurofibrillary tangles (consisting of both
45:
138:. Men and women appear to be equally affected. FTD generally presents as a behavioral or language disorder with gradual onset. Signs and symptoms tend to appear in late adulthood, typically between the ages of 45 and 65, although it can affect people younger or older than this. Currently, no cure or approved symptomatic treatment for FTD exists, although some
252:(oniomania), vulgar speech characteristics, screaming, inability to control emotions, behavior, personality, and temperament are characteristic social display patterns. A gradual onset and progression of changes in behavior or language deficits are reported to have begun several years prior to presentation to a neurologist.
815:
The Faux Pas
Recognition test is intended to measure one's ability to detect faux pas types of social blunders (accidentally making a statement or an action that offends others). It is suggested that people with orbitofrontal cortex dysfunction show a tendency to make social blunders due to a deficit
719:
The confusion between
Alzheimer's and FTD is justifiable due to the similarities between their initial symptoms. Patients do not have difficulty with movement and other motor tasks. As FTD symptoms appear, it is difficult to differentiate between a diagnosis of Alzheimer's disease and FTD. There are
820:
signals. The social emotions such as embarrassment are important in the way that they alert the individual to adapt social behavior in an appropriate manner to maintain relationships with others. Though patients with damage to the OFC retain intact knowledge of social norms, they fail to apply it to
800:
and the temporal lobe. Thus, the detection of dysfunction of the orbitofrontal cortex and ventromedial cortex is important in the detection of early stage bvFTD. As stated above, a behavioural change may occur before the appearance of any atrophy in the brain in the course of the disease. Because of
728:
Recent studies over several years have developed new criteria for the diagnosis of behavioral variant frontotemporal dementia (bvFTD). The confirmatory diagnosis is made by brain biopsy, but other tests can be used to help, such as MRI, EEG, CT, and physical examination and history. As of 2011, six
679:
Structural MRI scans often reveal frontal lobe and/or anterior temporal lobe atrophy, but in early cases the scan may seem normal. Atrophy can be either bilateral or asymmetric. Registration of images at different points of time (e.g., one year apart) can show evidence of atrophy that otherwise at
772:
Of the six features, three must be present in a patient to diagnose one with possible bvFTD. Similar to standard FTD, the primary diagnosis stems from clinical trials that identify the associated symptoms, instead of imaging studies. The above criteria are used to distinguish bvFTD from disorders
831:
The symptoms observed in bvFTD are caused by dysfunction of the orbitofrontal cortex; thus these two neuropsychological tests might be useful in detecting early-stage bvFTD. However, as self-monitoring and somatic marker processes are so complex, it likely involves other brain regions. Therefore,
928:
to describe the patient with predominant left temporal atrophy and aphasia that Pick described. The first research criteria for FTD, "Clinical and neuropathological criteria for frontotemporal dementia. The Lund and
Manchester Groups", was developed in 1994. The clinical diagnostic criteria were
835:
In order to solve this problem, some researchers have combined neuropsychological tests which detect the dysfunction of orbitofrontal cortex into one grouping, so that it increases its specificity to the degeneration of the frontal lobe, in order to detect early-stage bvFTD. They invented the
929:
revised in the late 1990s, when the FTD spectrum was divided into a behavioral variant, a nonfluent aphasia variant, and a semantic dementia variant. The most recent revision of the clinical research criteria was by the
International Behavioural Variant FTD Criteria Consortium in 2011.
292:, and is the most common of the FTD types. BvFTD is diagnosed four times as often as the PPA variants. Behavior can change in BvFTD in either of two ways—it can change to being impulsive and disinhibited, acting in socially unacceptable ways; or it can change to being listless and
220:
Frontotemporal dementia is an early onset disorder that mostly occurs between the ages of 45 and 65, but can begin earlier, and in 20–25% of cases onset is later. Men and women appear to be equally affected. It is the most common early presenting dementia. FTD is the second most
724:
seen in FTD patients. In the early stages of FTD, anxiety and depression are common, which may result in an ambiguous diagnosis. However, over time, these ambiguities fade away as this dementia progresses and defining symptoms of apathy, unique to FTD, start to appear.
711:
is a major locus of dysfunction early on in the course of the behavioural variant of frontotemporal degeneration. The language subtypes of FTLD (semantic dementia and progressive nonfluent aphasia) can be regionally dissociated by imaging approaches
526:
is also variable in families with mutations outside of exon 10. This disease is now informally designated FTDP-17T. FTD shows a linkage to the region of the tau locus on chromosome 17, but it is believed that there are two loci leading to FTD within
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in self-monitoring. Self-monitoring is the ability of individuals to evaluate their own behavior to make sure that their behavior is appropriate in particular situations. The impairment in self-monitoring leads to a lack of
832:
neuropsychological tests are sensitive to the dysfunction of orbitofrontal cortex, yet are not specific to it. The weakness of these tests is that they do not necessarily show dysfunction of the orbitofrontal cortex.
676:: These are behavioural variant frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia. An overlap between symptoms can occur as the disease progresses and spreads through the brain regions.
626:
There are three main histological subtypes found at post-mortem: FTLD-tau, FTLD-TDP, and FTLD-FUS. In rare cases, patients with clinical FTD were found to have changes consistent with
Alzheimer's disease on
6201:
773:
such as
Alzheimer's and other causes of dementia. In addition, the criteria allow for a diagnostic hierarchy distinguished possible, probable, and definite bvFTD based on the number of symptoms present.
503:
2402:
Kramer JH, Jurik J, Sha SJ, Rankin KP, Rosen HJ, Johnson JK, et al. (December 2003). "Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and
Alzheimer disease".
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FTD is traditionally difficult to diagnose owing to the diverse nature of the associated symptoms. Signs and symptoms are classified into three groups based on the affected functions of the
895:
Symptoms of frontotemporal dementia progress at a rapid, steady rate. Patients with the disease can survive for 2–20 years. Eventually patients will need 24-hour care for daily function.
365:. NIFID has an early age of onset between 23 and 56. Symptoms can include behavioural, and personality changes, memory and cognitive impairments, language difficulties, motor weakness, and
4108:
5750:
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917:
was coined in 1922. This term is now reserved only for behavioral variant FTD which shows the presence of the characteristic Pick bodies and Pick cells, which were first described by
153:
was coined in 1922. This term is now reserved only for the behavioral variant of FTD, in which characteristic Pick bodies and Pick cells are present. These were first described by
428:
and snatching food from others. Recent findings from structural MRI research have indicated that eating changes in FTD are associated with atrophy (wasting) in the right ventral
4272:
812:
as an alternative to imaging for the diagnosis of bvFTD. Both the Iowa gambling task and the Faux Pas test are known to be sensitive to dysfunction of the orbitofrontal cortex.
887:
Because FTD often occurs in relatively younger adults (i.e. in their 40s or 50s), it can severely affect families. Patients often still have children living in the home.
2446:
Olney RK, Murphy J, Forshew D, Garwood E, Miller BL, Langmore S, et al. (December 2005). "The effects of executive and behavioral dysfunction on the course of ALS".
272:
or FTD-MND). Two distinct rare subtypes are neuronal intermediate filament inclusion disease (NIFID), and basophilic inclusion body disease (BIBD). Related disorders are
1610:
5946:
197:
3131:
Schroeter ML, Raczka K, Neumann J, Yves von Cramon D (July 2007). "Towards a nosology for frontotemporal lobar degenerations-a meta-analysis involving 267 subjects".
703:
Meta-analyses based on imaging methods have shown that frontotemporal dementia mainly affects a frontomedial network discussed in the context of social cognition or "
5941:
2685:"How do C9ORF72 repeat expansions cause amyotrophic lateral sclerosis and frontotemporal dementia: can we learn from other noncoding repeat expansion disorders?"
3435:
Beer JS, John OP, Scabini D, Knight RT (June 2006). "Orbitofrontal cortex and social behavior: integrating self-monitoring and emotion-cognition interactions".
5743:
872:
Currently, there is no cure for FTD. Treatments are available to manage the behavioral symptoms. Disinhibition and compulsive behaviors can be controlled by
3943:
1801:
824:
The other test, the Iowa gambling task, is a psychological test intended to simulate real-life decision making. The underlying concept of this test is the
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4853:
4666:
237:
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5736:
4646:
2260:
Munoz DG, Neumann M, Kusaka H, Yokota O, Ishihara K, Terada S, et al. (November 2009). "FUS pathology in basophilic inclusion body disease".
873:
4020:
4116:
3531:
Swartz JR, Miller BL, Lesser IM, Darby AL (May 1997). "Frontotemporal dementia: treatment response to serotonin selective reuptake inhibitors".
424:
and compulsive behaviors. Binge eating habits are often associated with changes in food preferences (cravings for more sweets, carbohydrates),
6539:
6212:
4972:
4039:
6564:
6196:
3974:
1431:
1229:
2213:"Basophilic inclusions and neuronal intermediate filament inclusions in amyotrophic lateral sclerosis and frontotemporal lobar degeneration"
180:, while other neuron types remain intact. The three main subtypes or variant syndromes are a behavioral variant (bvFTD) previously known as
6402:
6390:
5852:
3875:
898:
2164:"Spatial patterns of FUS-immunoreactive neuronal cytoplasmic inclusions (NCI) in neuronal intermediate filament inclusion disease (NIFID)"
780:(CSF) biomarkers of pathologic amyloid plaques, tangles, and neurodegeneration, collectively called ATN, can be useful in diagnosing FTD.
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4581:
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370:
201:
169:
91:
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van der Zee J, Van
Broeckhoven C (February 2014). "Dementia in 2013: frontotemporal lobar degeneration-building on breakthroughs".
498:. More and more mutations and genetic variants are being identified all the time, needing constant updating of genetic influences.
1483:
5561:
4798:
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653:
2998:"DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication"
1863:
494:
A higher proportion of frontotemporal dementias seem to have a familial component than other neurodegenerative diseases such as
6443:
4803:
4598:
4523:
880:. Although Alzheimer's and FTD share certain symptoms, they cannot be treated with the same pharmacological agents because the
801:
that, image scanning such as MRI can be insensitive to the early degeneration and it is difficult to detect early-stage bvFTD.
681:
531:
of each other on chromosome 17. The only other known autosomal dominant genetic cause of FTLD-tau is a hypomorphic mutation in
507:
311:
of affected cells. They consist of tau fibrils as a major component together with a number of other protein products including
3047:
Schroeter ML, Raczka K, Neumann J, von Cramon DY (March 2008). "Neural networks in frontotemporal dementia--a meta-analysis".
5958:
5934:
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3393:"A neuropsychological battery to detect specific executive and social cognitive impairments in early frontotemporal dementia"
1966:
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708:
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277:
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3908:
6637:
6522:
6438:
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5929:
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2491:"Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease"
1245:
1124:
551:
479:
342:
209:
193:
2734:"DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms"
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5182:
4715:
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3969:
697:
5703:
2824:"Physiological and pathological functions of TMEM106B: a gene associated with brain aging and multiple brain disorders"
486:. As of 2005, the prognosis for people with ALS was worse when combined with FTD, shortening survival by about a year.
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4890:
4688:
4296:
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451:. Most become unable to perform skills that require complex planning or sequencing. In addition to the characteristic
261:
185:
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788:
The progression of the degeneration caused by bvFTD may follow a predictable course. The degeneration begins in the
6594:
6144:
5816:
5640:
4555:
4180:"A study of stereotypic behaviours in Alzheimer's disease and frontal and temporal variant frontotemporal dementia"
692:
scans classically show frontal and/or anterior temporal hypometabolism, which helps differentiate the disease from
559:
543:
532:
268:(svPPA) and progressive nonfluent aphasia (nfvPPA) – as well as FTD associated with amyotrophic lateral sclerosis (
249:
6486:
1317:
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6512:
6464:
6313:
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5650:
5619:
4997:
4880:
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1836:
945:
825:
632:
547:
4774:
3488:
Damasio AR (October 1996). "The somatic marker hypothesis and the possible functions of the prefrontal cortex".
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5698:
5614:
5609:
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5269:
5261:
5079:
5048:
4789:
4395:
844:
809:
707:". This is entirely in keeping with the notion that on the basis of cognitive neuropsychological evidence, the
6616:
3727:
2773:
Dobson-Stone C, Hallupp M, Shahheydari H, Ragagnin AM, Chatterton Z, Carew-Jones F, et al. (March 2020).
2162:
Armstrong RA, Gearing M, Bigio EH, Cruz-Sanchez FF, Duyckaerts C, Mackenzie IR, et al. (November 2011).
1829:
The ICD-10 Classification of Mental and
Behavioural Disorders Clinical descriptions and diagnostic guidelines
6549:
6305:
5975:
5965:
5809:
5635:
5142:
4992:
4944:
4761:
1266:
Sivasathiaseelan H, Marshall CR, Agustus JL, Benhamou E, Bond RL, van
Leeuwen JE, et al. (April 2019).
1058:
563:
555:
374:
366:
3290:"ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration"
680:
individual time points may be reported as normal. Many research groups have begun using techniques such as
6683:
6481:
6473:
6428:
6104:
6076:
5924:
5513:
5152:
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5002:
4977:
4885:
3880:
3444:
1991:
Sleegers K, Cruts M, Van Broeckhoven C (2010). "Molecular pathways of frontotemporal lobar degeneration".
877:
693:
495:
230:
135:
864:
The result has shown that this combined test is more sensitive in detecting the deficits in early bvFTD.
334:
understanding, resulting in impaired word comprehension. However, speech remains fluent and grammatical.
6678:
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6370:
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6081:
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5914:
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444:
401:
362:
273:
205:
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actual behavior, because they fail to generate social emotions that promote adaptive social behavior.
688:, and cortical thickness measurements in an attempt to offer an earlier diagnosis to the FTD patient.
6433:
6250:
6139:
5533:
5446:
5202:
5022:
4623:
4603:
4109:"Mark Wirtz, musician and producer who had a global hit with Excerpt from a Teenage Opera – obituary"
3753:
1076:
789:
483:
437:
297:
226:
131:
3449:
2587:
Darwich NF, Phan JM, Kim B, Suh E, Papatriantafyllou JD, Changolkar L, et al. (November 2020).
412:
Another rare FTD variant, also a FTLD-FUS proteopathy, is basophilic inclusion body disease (BIBD).
6362:
6009:
5864:
5804:
5583:
5565:
5528:
5518:
5372:
5274:
5251:
5099:
5091:
4870:
4848:
4576:
4367:
3241:"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia"
777:
758:
420:
In later stages of FTD, the clinical phenotypes may overlap. People with FTD tend to struggle with
176:
loss predominantly involving the frontal or temporal lobes, and a typical loss of more than 70% of
4040:"Sir Nicholas Wall, once Britain's top family law judge, commits suicide after dementia diagnosis"
3239:
Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, et al. (September 2011).
2914:"Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration"
804:
In neuropsychology, there is an increasing interest in using neuropsychological tests such as the
6532:
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805:
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distinct differences in the behavioral and emotional symptoms of the two dementias, notably, the
685:
464:
463:
are often able to be elicited. Usually the first of these frontal release signs to appear is the
456:
260:
The main subtypes of frontotemporal dementia are behavioral variant FTD (bvFTD), two variants of
245:
5728:
3885:
1889:
157:
in 1911. Common signs and symptoms include significant changes in social and personal behavior,
2316:
Piguet O (November 2011). "Eating disturbance in behavioural-variant frontotemporal dementia".
6673:
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6261:
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6224:
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4166:
3658:
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3505:
3462:
3414:
3368:
3319:
3270:
3197:
3176:"Impact of DNA testing for early-onset familial Alzheimer disease and frontotemporal dementia"
3148:
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2008:
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189:
72:
4342:
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2912:
Rohrer JD, Lashley T, Schott JM, Warren JE, Mead S, Isaacs AM, et al. (September 2011).
538:
FTD caused by FTLD-TDP43 has numerous genetic causes. Some cases are due to mutations in the
6418:
6289:
6284:
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Abugable AA, Morris JL, Palminha NM, Zaksauskaite R, Ray S, El-Khamisy SF (September 2019).
2704:
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2510:
2502:
2455:
2412:
2368:
2325:
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2183:
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2123:
2112:"Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease"
2047:
2039:
2000:
1938:
1930:
1823:
1765:
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1707:
1699:
1688:"Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management"
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984:
354:
304:
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Liu W, Miller BL, Kramer JH, Rankin K, Wyss-Coray C, Gearhart R, et al. (March 2004).
3997:
1510:"FRONTotemporal dementia Incidence European Research Study-FRONTIERS: Rationale and design"
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Cairns NJ, Grossman M, Arnold SE, Burn DJ, Jaros E, Perry RH, et al. (October 2004).
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1002:
918:
631:. The most severe brain atrophy appears to be associated with behavioral variant FTD, and
425:
393:
241:
154:
56:
5588:
3060:
1224:(5th ed.). Arlington, VA: American Psychiatric Association. 2013. pp. 614–618.
353:
Neuronal intermediate filament inclusion disease (NIFID) is a rare distinct variant. The
3490:
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
2004:
1508:
Borroni B, Graff C, Hardiman O, Ludolph AC, Moreno F, Otto M, et al. (March 2022).
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3314:
3289:
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3024:
2997:
2938:
2913:
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2799:
2774:
2709:
2684:
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2515:
2506:
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2136:
2127:
2111:
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2027:
1943:
1918:
1770:
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1712:
1687:
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1561:
1534:
1509:
1396:
1371:
1267:
1198:
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1088:
993:
980:
817:
704:
472:
448:
429:
177:
4435:
4137:"Behavioral disorders in the frontal and temporal variants of frontotemporal dementia"
2775:"CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis"
2372:
2043:
6662:
6423:
6375:
6245:
6014:
5970:
5821:
5557:
5508:
4826:
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3288:
Cousins KA, Phillips JS, Irwin DJ, Lee EB, Wolk DA, Shaw LM, et al. (May 2021).
3144:
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970:
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754:
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377:
168:
Each FTD subtype is relatively rare. FTDs are mostly early onset syndromes linked to
158:
139:
123:
4458:
4229:. In Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJ, Gripp KW, Amemiya A (eds.).
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2532:
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2432:
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2345:
2299:
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1349:
1299:
660:
have been etiologically linked to various neurodegenerative diseases including FTD.
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5772:
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3798:
3517:
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1094:
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381:
119:
64:
60:
3220:
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2637:
983:(1947–2016), frontman, organist and keyboardist of American psychedelic rock band
562:, and FTD. The most recent addition to the list (as of 2019) was a hexanucleotide
269:
4400:
3354:
2873:"Clinical and psychometric distinction of frontotemporal and Alzheimer dementias"
2750:
2733:
2700:
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1333:
638:
With regard to the genetic defects that have been found, repeat expansion in the
5878:
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5396:
5127:
4858:
4608:
4441:
3965:"Support for Valiants hero Ernie Moss after he is diagnosed with Pick's Disease"
3916:
3215:
3192:
3175:
2638:"Review: Clinical, genetic and neuroimaging features of frontotemporal dementia"
2084:
1868:
1826:, Henderson A, Strotzka H, Lipowski Z, Yu-cun S, You-xin X, et al. (1992).
1562:"RNA Binding Proteins and the Pathogenesis of Frontotemporal Lobar Degeneration"
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4411:
4178:
Nyatsanza S, Shetty T, Gregory C, Lough S, Dawson K, Hodges JR (October 2003).
3704:
3458:
3108:
3091:
2839:
1453:
44:
5989:
5859:
5713:
5406:
5311:
5012:
4737:
4732:
4528:
4446:
4430:
4357:
4247:
4222:
3654:
3609:
3337:
Krueger CE, Bird AC, Growdon ME, Jang JY, Miller BL, Kramer JH (August 2009).
3014:
2974:
2889:
2872:
2329:
2273:
2179:
1934:
1189:
1100:
1054:
1048:
1009:
996:
657:
601:
586:
77:
3092:"Specific cognitive deficits in mild frontal variant frontotemporal dementia"
2589:"Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau"
1341:
1017:(1933–2009), sports agent and ice hockey team manager, known as "Mrs. Hockey"
6099:
6050:
6038:
6021:
5953:
5666:
5598:
5416:
4875:
4613:
4538:
4195:
2790:
2604:
331:
312:
308:
293:
222:
127:
81:
52:
4263:
4238:
4213:
4170:
4021:"The Sexy, Proto-Feminist Art Of Christina Ramberg's Tragically Short Life"
3662:
3627:
3501:
3466:
3418:
3409:
3392:
3372:
3323:
3274:
3256:
3201:
3152:
3117:
3068:
3033:
2982:
2947:
2929:
2898:
2857:
2808:
2759:
2718:
2661:
2622:
2573:
2564:
2547:
2524:
2467:
2424:
2380:
2337:
2291:
2238:
2197:
2145:
2061:
2012:
1952:
1779:
1721:
1669:
1595:
1543:
1469:
1405:
1291:
1283:
1207:
535:
which is associated with a unique neuropathology called vacuolar tauopathy.
288:
Behavioral variant frontotemporal dementia (BvFTD) was previously known as
17:
3820:
3594:"Diagnosis and management of behavioral issues in frontotemporal dementia"
3552:
3509:
1660:
1643:
1387:
345:(PNFA) is characterized by progressive difficulties in speech production.
303:
The Pick bodies which are present in behavioral variant FTD are spherical
6279:
6271:
6237:
6091:
5994:
5401:
5071:
5038:
4964:
3544:
3391:
Torralva T, Roca M, Gleichgerrcht E, Bekinschtein T, Manes F (May 2009).
1129:
745:
700:
scan in Alzheimer's disease classically shows biparietal hypometabolism.
643:
642:
gene is considered a major contribution to FTLD, although defects in the
608:
539:
528:
433:
385:
115:
3728:"Beastie Boy John Berry Died of Frontal Lobe Dementia – But What Is It?"
384:
commonly shows atrophy in the frontotemporal region, and in part of the
3090:
Rahman S, Sahakian BJ, Hodges JR, Rogers RD, Robbins TW (August 1999).
2683:
van Blitterswijk M, DeJesus-Hernandez M, Rademakers R (December 2012).
2359:
Neary D, Snowden J, Mann D (November 2005). "Frontotemporal dementia".
2229:
2212:
749:
689:
639:
628:
567:
316:
162:
3305:
2653:
2548:"Frontal temporal dementia: dissecting the aetiology and pathogenesis"
2282:
1525:
729:
distinct clinical features have been identified as symptoms of bvFTD.
581:
Several other genes have been linked to this condition. These include
542:
gene, also located on chromosome 17. Others are caused by hypomorphic
6318:
6059:
6026:
5119:
4934:
4352:
4337:
738:
590:
575:
571:
546:
mutations, although these patients present with a complex picture of
173:
4325:
4085:"Bruce Willis Diagnosed With Dementia After Retiring Due to Aphasia"
4059:"Wendy Williams Diagnosed With Frontotemporal Dementia and Apahasia"
937:
People who have been diagnosed as having FTD (often referred to as
6574:
Spinal muscular atrophy with lower extremity predominance (SMALED)
4897:
3676:
Samson K (2002). "Hypotension May Cause Frontotemporal Dementia".
397:
3641:
Kertesz A (June 2004). "Frontotemporal dementia/Pick's disease".
467:
which appears relatively early in the disease course whereas the
4389:
4386:
4383:
523:
504:
frontotemporal dementia and parkinsonism linked to chromosome 17
5732:
5687:
5555:
5490:
5342:
5069:
4914:
4824:
4644:
4505:
4462:
1454:"Frontotemporal dementia: a review for primary care physicians"
909:
Features of FTD were first described by the Czech psychiatrist
961:(born 1960), American developmental psychologist and professor
3174:
Steinbart EJ, Smith CO, Poorkaj P, Bird TD (November 2001).
1222:
Diagnostic and statistical manual of mental disorders: DSM-5
1008:
Lee Holloway (born 1982), computer scientist, co-founder of
597:. These genes have been implicated in the autophagy pathway.
3705:"Uber die Beziehungen der senilen Hirnatrophie zur Aphasie"
1890:"What are the Different Types of Frontotemporal Disorders?"
690:
Fluorine-18-fluorodeoxyglucose positron emission tomography
578:
gene) mutations in a clinically pure FTD (FTD without ALS).
2871:
Liscic RM, Storandt M, Cairns NJ, Morris JC (April 2007).
248:
aspects of the human organism. Dissociation from family,
240:
recognizes the disease as causative to disorder affecting
901:
are a known cause of reversible frontotemporal dementia.
876:(SSRIs). Agitation can be controlled with small doses of
27:
Types of dementia involving the frontal or temporal lobes
3998:"Nic Potter obituary | Music | guardian.co.uk"
796:. In later stages, it gradually expands its area to the
611:
SNPs have been found to be associated with risk of FTLD.
4254:. In Adam MP, Mirzaa GM, Pagon RA, et al. (eds.).
1971:
National Institute of Neurological Disorders and Stroke
1798:
National Institute of Neurological Disorders and Stroke
1029:(1942–2020), Welsh comedian (Monty Python) and director
3339:"Conflict monitoring in early frontotemporal dementia"
570:. Only one or two cases have been reported describing
518:) and Pick bodies (consisting of 3-repeat tau) having
161:, apathy, blunting and dysregulation of emotions, and
118:
involving the progressive degeneration of the brain's
392:. Post-mortem studies show a marked reduction in the
55:
of a 65-year-old woman with frontotemporal dementia.
4315:
4297:"The Devastating Decline of a Brilliant Young Coder"
3855:"The Devastating Decline of a Brilliant Young Coder"
1800:. U.S. National Institutes of Health. Archived from
6495:
6472:
6463:
6456:
6411:
6361:
6333:
6304:
6270:
6232:
6221:
6187:
6165:
6090:
5900:
5891:
5877:
5837:
5780:
5771:
5659:
5628:
5597:
5576:
5455:
5432:
5386:
5353:
5260:
5227:
5175:
5118:
5109:
5090:
5031:
4963:
4925:
4785:
4760:
4657:
4569:
4516:
4421:
4319:
1452:Cardarelli R, Kertesz A, Knebl JA (December 2010).
87:
71:
37:
4184:Journal of Neurology, Neurosurgery, and Psychiatry
3754:"Don Cardwell, 72, Pitcher for 1969 Mets, Is Dead"
1376:Journal of Neurology, Neurosurgery, and Psychiatry
1066:(1946–1995), American painter associated with the
163:deficits in both expressive and receptive language
3234:
3232:
3230:
3228:
3876:"Fans mourn loss of "Mrs. Hockey," Colleen Howe"
1560:Hofmann JW, Seeley WW, Huang EJ (January 2019).
1447:
1445:
1443:
1426:(eleventh ed.). McGraw Hill. p. 1096.
1103:(1943–2020), pop musician, composer and producer
349:Neuronal intermediate filament inclusion disease
198:neuronal intermediate filament inclusion disease
196:(nfvPPA). Two rare distinct subtypes of FTD are
3386:
3384:
3382:
2996:Wang H, Kodavati M, Britz GW, Hegde ML (2021).
1637:
1635:
1633:
1631:
840:which comprises five neuropsychological tests:
4258:. Seattle: University of Washington, Seattle.
3774:"Sugarloaf frontman Jerry Corbetta dead at 68"
2636:Convery R, Mead S, Rohrer JD (February 2019).
2311:
2309:
1642:Snowden JS, Neary D, Mann DM (February 2002).
1503:
1501:
172:(FTLD), which is characterized by progressive
5744:
4474:
4273:"'Til Death or Dementia Do us Part, a memoir"
3940:"Grimsby Town legend Kevin Moore passes away"
1858:
1856:
1417:
1415:
1246:"ICD-11 – Mortality and Morbidity Statistics"
941:in cases of the behavioral variant) include:
142:drugs and behavioral methods are prescribed.
8:
2546:Hardy J, Momeni P, Traynor BJ (April 2006).
2157:
2155:
1365:
1363:
1361:
1359:
1268:"Frontotemporal Dementia: A Clinical Review"
478:In rare cases, FTD can occur in people with
443:People with FTD show marked deficiencies in
296:. About 12–13% of people with bvFTD develop
3430:
3428:
2026:Bang J, Spina S, Miller BL (October 2015).
1311:
1309:
404:, and the lateral ventricles are enlarged.
6469:
6460:
6229:
5897:
5888:
5777:
5751:
5737:
5729:
5684:
5573:
5552:
5487:
5378:Other specified feeding or eating disorder
5350:
5339:
5115:
5087:
5066:
4922:
4911:
4821:
4654:
4641:
4513:
4502:
4481:
4467:
4459:
4316:
3909:"Kazi Nazrul Islam: Illness and Treatment"
3598:Current Neurology and Neuroscience Reports
1967:"Frontotemporal Dementia Information Page"
1555:
1553:
1424:Adams and Victor's Principles of Neurology
1261:
1259:
967:(1935–2008), Major League Baseball pitcher
284:Behavioral variant frontotemporal dementia
43:
34:
4203:
4160:
3617:
3448:
3408:
3362:
3313:
3264:
3191:
3107:
3023:
3013:
2937:
2888:
2847:
2798:
2749:
2708:
2612:
2563:
2514:
2281:
2228:
2187:
2135:
2105:
2103:
2101:
2051:
1986:
1984:
1982:
1980:
1942:
1917:Olney NT, Spina S, Miller BL (May 2017).
1912:
1910:
1769:
1739:
1737:
1735:
1733:
1731:
1711:
1659:
1585:
1578:10.1146/annurev-pathmechdis-012418-012955
1533:
1395:
1197:
1172:Olney NT, Spina S, Miller BL (May 2017).
510:T gene on chromosome 17 that encodes the
5641:Disorganized (hebephrenic) schizophrenia
5237:Depersonalization-derealization disorder
3573:. University of California San Francisco
1794:"Focus on Frontotemporal Dementia (FTD)"
1422:Ropper AH, Samuels MA, Klein JP (2019).
973:(1942–2016), who played Liesl, from the
604:pathology in FTD have yet been reported.
506:(FTDP-17) is caused by mutations in the
238:International Classification of Diseases
204:(BIBD). Other related disorders include
145:Features of FTD were first described by
3592:Manoochehri M, Huey ED (October 2012).
2822:Feng T, Lacrampe A, Hu F (March 2021).
2642:Neuropathology and Applied Neurobiology
1167:
1165:
1163:
1161:
1157:
1023:(1899–1976) national poet of Bangladesh
874:selective serotonin reuptake inhibitors
767:Dysexecutive neuropsychological profile
400:are narrowed, with widened intervening
112:frontotemporal neurocognitive disorder,
6540:Distal hereditary motor neuronopathies
6213:Template:Demyelinating diseases of CNS
1681:
1679:
838:Executive and Social Cognition Battery
522:. The presence of tau deposits within
4233:. Seattle: University of Washington.
3567:"Medications for behavioral symptoms"
2489:Buée L, Delacourte A (October 1999).
1973:. U.S. National Institutes of Health.
1686:Rabinovici GD, Miller BL (May 2010).
330:(SD) is characterized by the loss of
7:
6391:Idiopathic intracranial hypertension
3061:10.1016/j.neurobiolaging.2006.10.023
952:musician and founding member of the
924:In 1989, Snowden suggested the term
776:A 2021 study, determined that using
5344:Physiological and physical behavior
3002:Frontiers in Molecular Neuroscience
2005:10.1146/annurev-neuro-060909-153144
650:genes are also associated with it.
475:appear late in the disease course.
108:frontotemporal degeneration disease
6622:Infantile progressive bulbar palsy
5290:Psychogenic non-epileptic seizures
4684:Emotional and behavioral disorders
4246:Rohrer J, Ryan B, Ahmed R (1993).
4153:10.1212/01.WNL.0000113729.77161.C9
3533:The Journal of Clinical Psychiatry
2507:10.1111/j.1750-3639.1999.tb00550.x
2460:10.1212/01.wnl.0000188759.87240.8b
2405:Cognitive and Behavioral Neurology
2128:10.1212/01.wnl.0000139809.16817.dd
913:between 1892 and 1906. The name
25:
6325:Template:Cerebrovascular diseases
6128:Frontotemporal lobar degeneration
5470:Hypoactive sexual desire disorder
4252:-Related Frontotemporal Dementia"
3973:. 11 October 2014. Archived from
3571:Weill Institute for Neurosciences
3437:Journal of Cognitive Neuroscience
2318:Journal of Molecular Neuroscience
1864:"What is frontotemporal dementia"
1648:The British Journal of Psychiatry
1091:(born 1964), American broadcaster
1057:(1951–2013), British bassist for
884:systems are not affected in FTD.
622:Frontotemporal lobar degeneration
408:Basophilic inclusion body disease
371:frontotemporal lobar degeneration
202:basophilic inclusion body disease
170:frontotemporal lobar degeneration
92:frontotemporal lobar degeneration
6345:For more detailed coverage, see
6323:For more detailed coverage, see
6294:For more detailed coverage, see
6260:For more detailed coverage, see
6211:For more detailed coverage, see
4770:X-linked intellectual disability
4115:. 13 August 2020. Archived from
3690:10.1097/00132985-200209000-00013
3145:10.1016/j.neuroimage.2007.03.024
2417:10.1097/00146965-200312000-00002
1704:10.2165/11533100-000000000-00000
396:of the striatum; frontotemporal
149:between 1892 and 1906. The name
4599:Intermittent explosive disorder
4524:Ego-dystonic sexual orientation
3752:Goldstein R (16 January 2008).
1051:(1949–2021), English footballer
1045:(1958–2013), English footballer
1005:(1936–2001), computer scientist
682:magnetic resonance spectroscopy
5242:Dissociative identity disorder
4507:Adult personality and behavior
4221:Hsiung GY, Feldman HH (1993).
2168:Journal of Neural Transmission
1486:. Johns Hopkins Medicine. 2024
798:dorsolateral prefrontal cortex
794:ventromedial prefrontal cortex
709:ventromedial prefrontal cortex
357:that are present in NIFID are
278:progressive supranuclear palsy
256:Subtypes and related disorders
1:
6638:Amyotrophic lateral sclerosis
6523:Hereditary spastic paraplegia
6381:Normal pressure hydrocephalus
4038:Rayner G (23 February 2017).
3803:"Robert W Floyd, In Memoriam"
2373:10.1016/S1474-4422(05)70223-4
2044:10.1016/S0140-6736(15)00461-4
1993:Annual Review of Neuroscience
1611:"Brain Cells for Socializing"
1125:Logopenic progressive aphasia
552:amyotrophic lateral sclerosis
480:amyotrophic lateral sclerosis
343:Progressive nonfluent aphasia
338:Progressive nonfluent aphasia
210:amyotrophic lateral sclerosis
114:encompasses several types of
6607:Progressive muscular atrophy
5646:Pseudoneurotic schizophrenia
5183:Generalized anxiety disorder
4916:Neurological and symptomatic
4561:Sexual relationship disorder
3996:Potter S (22 January 2013).
3355:10.1212/wnl.0b013e3181b04b24
2751:10.1016/j.dnarep.2019.102669
2701:10.1097/WCO.0b013e32835a3efb
2689:Current Opinion in Neurology
1762:10.1212/CON.0000000000000300
1334:10.1016/j.neurol.2018.09.009
1097:(born 1955), American actor
6117:Primary progressive aphasia
5422:REM sleep behavior disorder
4891:Seasonal affective disorder
4689:Separation anxiety disorder
4057:Shah S (22 February 2024).
4019:Cook G (27 February 2014).
3193:10.1001/archneur.58.11.1828
2081:Radiology Reference Article
1894:National Institute on Aging
1370:Pearce JM (February 2003).
1318:"History of Pick's disease"
977:, born Charmian Anne Farnon
792:and medial aspects such as
262:primary progressive aphasia
208:(CBS or CBD), and FTD with
186:primary progressive aphasia
6700:
6439:Hashimoto's encephalopathy
6145:Posterior cortical atrophy
5966:Striatonigral degeneration
5817:Cavernous sinus thrombosis
5689:Symptoms and uncategorized
4790:developmental disabilities
4556:Sexual maturation disorder
3874:Sipple G (March 6, 2009).
3459:10.1162/jocn.2006.18.6.871
3294:Alzheimer's & Dementia
2840:10.1007/s00401-020-02246-3
1746:"Frontotemporal Dementias"
1566:Annual Review of Pathology
1514:Alzheimer's & Dementia
1085:(1945–2017), English judge
619:
250:compulsive buying disorder
6545:Spinal muscular atrophies
6513:Primary lateral sclerosis
6371:Intracranial hypertension
6151:Creutzfeldt–Jakob disease
5694:
5683:
5651:Simple-type schizophrenia
5620:Schizophreniform disorder
5572:
5551:
5504:
5486:
5349:
5338:
5086:
5065:
4998:Mild cognitive impairment
4983:Creutzfeldt–Jakob disease
4921:
4910:
4881:Major depressive disorder
4834:
4820:
4786:Psychological development
4653:
4640:
4512:
4501:
4295:Upson S (15 April 2020).
3853:Upson S (15 April 2020).
3726:Oyebode J (31 May 2016).
3655:10.1001/archneur.61.6.969
3610:10.1007/s11910-012-0302-7
3015:10.3389/fnmol.2021.784361
2975:10.1038/nrneurol.2013.270
2963:Nature Reviews. Neurology
2890:10.1001/archneur.64.4.535
2330:10.1007/s12031-011-9547-x
2274:10.1007/s00401-009-0598-9
2180:10.1007/s00702-011-0690-x
2028:"Frontotemporal dementia"
1935:10.1016/j.ncl.2017.01.008
1919:"Frontotemporal Dementia"
1837:World Health Organization
1644:"Frontotemporal dementia"
1484:"Frontotemporal dementia"
1458:American Family Physician
1190:10.1016/j.ncl.2017.01.008
1174:"Frontotemporal dementia"
899:Cerebrospinal fluid leaks
826:somatic marker hypothesis
810:Faux Pas Recognition test
633:corticobasal degeneration
548:multisystem proteinopathy
516:3-repeat and 4-repeat tau
126:. FTD is the second most
51:
42:
6612:Progressive bulbar palsy
6403:Intracranial hypotension
6386:Choroid plexus papilloma
5800:Herpesviral encephalitis
5699:Impulse-control disorder
5615:Schizoaffective disorder
5610:Brief reactive psychosis
5307:Mass psychogenic illness
5270:Body dysmorphic disorder
5049:Post-concussion syndrome
4659:Emotional and behavioral
4227:Frontotemporal Dementia"
3216:MedlinePlus Encyclopedia
3109:10.1093/brain/122.8.1469
1744:Finger EC (April 2016).
784:Neuropsychological tests
6124:Frontotemporal dementia
5810:Encephalitis lethargica
5636:Childhood schizophrenia
4988:Frontotemporal dementia
4945:High-functioning autism
4762:Intellectual disability
4436:Frontotemporal dementia
4196:10.1136/jnnp.74.10.1398
4083:Moreau J (2023-02-16).
3221:Frontotemporal dementia
2605:10.1126/science.aay8826
2211:Ito H (December 2014).
1756:(2 Dementia): 464–489.
1059:Van der Graaf Generator
878:atypical antipsychotics
560:Paget's disease of bone
556:inclusion body myopathy
426:eating inedible objects
367:extrapyramidal symptoms
361:and made up of type IV
100:Frontotemporal dementia
67:is clear in all images.
38:Frontotemporal dementia
6429:Hepatic encephalopathy
5153:Specific social phobia
5044:Organic brain syndrome
4886:Melancholic depression
4647:Childhood and learning
4447:MAPT-Related Disorders
3881:The Detroit Free Press
3502:10.1098/rstb.1996.0125
1284:10.1055/s-0039-1683379
1077:cognitive psychologist
1075:(1942–2011), American
948:(1963–2016), American
658:repair of such damages
369:. NIFID is one of the
363:intermediate filaments
184:, and two variants of
6487:Ataxia–telangiectasia
6444:Static encephalopathy
6167:Mitochondrial disease
6005:Spasmodic torticollis
5915:Basal ganglia disease
5709:Psychomotor agitation
5499:and substance-related
5442:Postpartum depression
5322:Somatization disorder
5208:Acute stress reaction
4973:AIDS dementia complex
3821:10.1145/954092.954488
3643:Archives of Neurology
3180:Archives of Neurology
3049:Neurobiology of Aging
2877:Archives of Neurology
2828:Acta Neuropathologica
2791:10.1093/brain/awaa039
2361:The Lancet. Neurology
2262:Acta Neuropathologica
1661:10.1192/bjp.180.2.140
1388:10.1136/jnnp.74.2.169
1272:Seminars in Neurology
860:Multiple Errands task
600:No genetic causes of
461:frontal release signs
453:cognitive dysfunction
445:executive functioning
416:Other characteristics
274:corticobasal syndrome
206:corticobasal syndrome
6434:Toxic encephalopathy
6140:Lewy bodies dementia
5704:Klüver–Bucy syndrome
5534:Substance dependence
5447:Postpartum psychosis
4993:Huntington's disease
4775:Lujan–Fryns syndrome
4624:Personality disorder
3545:10.4088/jcp.v58n0506
3410:10.1093/brain/awp041
3257:10.1093/brain/awr179
2930:10.1093/brain/awr198
2565:10.1093/brain/awl035
2038:(10004): 1672–1682.
1609:Chen I (June 2009).
1035:(1942–2013), former
790:orbitofrontal cortex
759:Compulsive behaviors
484:motor neuron disease
438:orbitofrontal cortex
298:motor neuron disease
227:early onset dementia
132:early onset dementia
6669:Cognitive disorders
6482:Friedreich's ataxia
5865:Meningoencephalitis
5805:Limbic encephalitis
5584:Delusional disorder
5529:Stimulant psychosis
5519:Physical dependence
5373:Rumination syndrome
5275:Conversion disorder
5252:Psychogenic amnesia
5102:with depressed mood
5100:Adjustment disorder
5003:Parkinson's disease
4978:Alzheimer's disease
4871:Atypical depression
4707:Social functioning
4582:Munchausen syndrome
4577:Factitious disorder
4113:The Daily Telegraph
4044:The Daily Telegraph
3709:Prag Med Wochenschr
3496:(1346): 1413–1420.
3403:(Pt 5): 1299–1309.
3251:(Pt 9): 2456–2477.
2924:(Pt 9): 2565–2581.
778:cerebrospinal fluid
694:Alzheimer's disease
496:Alzheimer's disease
231:Alzheimer's disease
136:Alzheimer's disease
6518:Pseudobulbar palsy
6256:Status epilepticus
6207:Multiple sclerosis
6044:Myoclonic epilepsy
5907:movement disorders
5853:Acute disseminated
5795:Viral encephalitis
5603:schizophrenia-like
5247:Dissociative fugue
4696:Movement disorders
4422:External resources
4119:on 27 August 2020.
4000:. London: Guardian
3977:on 2 November 2014
3888:on October 4, 2015
3759:The New York Times
2599:(6519): eaay8826.
2230:10.1111/neup.12119
1923:Neurologic Clinics
1804:on 16 October 2021
1322:Revue Neurologique
1178:Neurologic Clinics
1120:Lewy body dementia
1115:Alcoholic dementia
1037:premier of Alberta
853:Iowa gambling task
806:Iowa gambling task
722:blunting of affect
686:functional imaging
656:and the defective
465:palmomental reflex
457:primitive reflexes
276:(CBS or CBD), and
216:Signs and symptoms
6656:
6655:
6652:
6651:
6648:
6647:
6452:
6451:
6357:
6356:
6296:Template:Headache
6262:Template:Epilepsy
6183:
6182:
6157:Vascular dementia
6000:Status dystonicus
5873:
5872:
5848:Encephalomyelitis
5726:
5725:
5722:
5721:
5679:
5678:
5675:
5674:
5547:
5546:
5482:
5481:
5478:
5477:
5334:
5333:
5330:
5329:
5223:
5222:
5061:
5060:
5057:
5056:
5018:Vascular dementia
4940:Asperger syndrome
4906:
4905:
4816:
4815:
4812:
4811:
4750:Tourette syndrome
4636:
4635:
4632:
4631:
4456:
4455:
4190:(10): 1398–1402.
3801:(December 2003).
3306:10.1002/alz.12233
3186:(11): 1828–1831.
2654:10.1111/nan.12535
2558:(Pt 4): 830–831.
2454:(11): 1774–1777.
2174:(11): 1651–1657.
1526:10.1002/alz.12414
1464:(11): 1372–1377.
1433:978-0-07-184262-4
1231:978-0-89042-554-1
1145:Vascular dementia
1064:Christina Ramberg
1021:Kazi Nazrul Islam
926:semantic dementia
607:Major alleles of
550:that can include
328:Semantic dementia
323:Semantic dementia
266:semantic dementia
97:
96:
32:Medical condition
16:(Redirected from
6691:
6470:
6461:
6419:Brain herniation
6230:
6070:Intention tremor
6065:Essential tremor
5930:Postencephalitic
5898:
5889:
5778:
5759:Diseases of the
5753:
5746:
5739:
5730:
5685:
5574:
5553:
5488:
5363:Anorexia nervosa
5351:
5340:
5317:Psychogenic pain
5285:Globus pharyngis
5133:Childhood phobia
5116:
5088:
5067:
4923:
4912:
4822:
4721:Selective mutism
4672:Conduct disorder
4655:
4642:
4619:Trichotillomania
4594:Gender dysphoria
4589:Fear of intimacy
4546:Sexual anhedonia
4514:
4503:
4490:Mental disorders
4483:
4476:
4469:
4460:
4317:
4311:
4309:
4307:
4291:
4289:
4288:
4279:. Archived from
4277:River Rock Books
4267:
4242:
4217:
4207:
4174:
4164:
4121:
4120:
4105:
4099:
4098:
4096:
4095:
4080:
4074:
4073:
4071:
4069:
4054:
4048:
4047:
4035:
4029:
4028:
4016:
4010:
4009:
4007:
4005:
3993:
3987:
3986:
3984:
3982:
3961:
3955:
3954:
3952:
3951:
3942:. Archived from
3935:
3929:
3928:
3926:
3924:
3915:. Archived from
3904:
3898:
3897:
3895:
3893:
3884:. Archived from
3871:
3865:
3864:
3850:
3844:
3843:
3841:
3840:
3831:. Archived from
3795:
3789:
3788:
3786:
3785:
3770:
3764:
3763:
3749:
3743:
3742:
3740:
3738:
3723:
3717:
3716:
3700:
3694:
3693:
3673:
3667:
3666:
3638:
3632:
3631:
3621:
3589:
3583:
3582:
3580:
3578:
3563:
3557:
3556:
3528:
3522:
3521:
3485:
3479:
3478:
3452:
3432:
3423:
3422:
3412:
3388:
3377:
3376:
3366:
3334:
3328:
3327:
3317:
3285:
3279:
3278:
3268:
3236:
3223:
3212:
3206:
3205:
3195:
3171:
3165:
3164:
3128:
3122:
3121:
3111:
3102:(8): 1469–1493.
3087:
3081:
3080:
3044:
3038:
3037:
3027:
3017:
2993:
2987:
2986:
2958:
2952:
2951:
2941:
2909:
2903:
2902:
2892:
2868:
2862:
2861:
2851:
2819:
2813:
2812:
2802:
2770:
2764:
2763:
2753:
2729:
2723:
2722:
2712:
2680:
2674:
2673:
2633:
2627:
2626:
2616:
2584:
2578:
2577:
2567:
2543:
2537:
2536:
2518:
2486:
2480:
2479:
2443:
2437:
2436:
2399:
2393:
2392:
2356:
2350:
2349:
2313:
2304:
2303:
2285:
2257:
2251:
2250:
2232:
2208:
2202:
2201:
2191:
2159:
2150:
2149:
2139:
2122:(8): 1376–1384.
2107:
2096:
2095:
2093:
2091:
2072:
2066:
2065:
2055:
2023:
2017:
2016:
1988:
1975:
1974:
1963:
1957:
1956:
1946:
1914:
1905:
1904:
1902:
1900:
1886:
1880:
1879:
1877:
1876:
1860:
1851:
1850:
1834:
1820:
1814:
1813:
1811:
1809:
1790:
1784:
1783:
1773:
1741:
1726:
1725:
1715:
1683:
1674:
1673:
1663:
1639:
1626:
1625:
1623:
1621:
1606:
1600:
1599:
1589:
1557:
1548:
1547:
1537:
1505:
1496:
1495:
1493:
1491:
1480:
1474:
1473:
1449:
1438:
1437:
1419:
1410:
1409:
1399:
1372:"Pick's disease"
1367:
1354:
1353:
1316:Mikol J (2018).
1313:
1304:
1303:
1263:
1254:
1253:
1242:
1236:
1235:
1218:
1212:
1211:
1201:
1169:
1068:Chicago Imagists
857:Mind in the Eyes
564:repeat expansion
355:inclusion bodies
305:inclusion bodies
47:
35:
21:
6699:
6698:
6694:
6693:
6692:
6690:
6689:
6688:
6659:
6658:
6657:
6644:
6570:Congenital DSMA
6491:
6448:
6407:
6353:
6341:Sleep disorders
6329:
6306:Cerebrovascular
6300:
6266:
6223:
6217:
6179:
6161:
6086:
6032:Choreoathetosis
5905:
5882:
5869:
5833:
5767:
5757:
5727:
5718:
5690:
5671:
5655:
5624:
5602:
5593:
5568:
5543:
5500:
5497:substance abuse
5474:
5451:
5428:
5382:
5368:Bulimia nervosa
5345:
5326:
5302:Hypochondriasis
5297:False pregnancy
5280:Ganser syndrome
5262:Somatic symptom
5256:
5219:
5171:
5160:Specific phobia
5105:
5082:
5053:
5027:
4959:
4955:Savant syndrome
4927:Autism spectrum
4917:
4902:
4830:
4808:
4787:
4781:
4756:
4649:
4628:
4604:Dermatillomania
4565:
4551:Sexual anorexia
4508:
4497:
4487:
4457:
4452:
4451:
4417:
4416:
4328:
4314:
4305:
4303:
4294:
4286:
4284:
4270:
4245:
4220:
4177:
4134:
4130:
4128:Further reading
4125:
4124:
4107:
4106:
4102:
4093:
4091:
4082:
4081:
4077:
4067:
4065:
4056:
4055:
4051:
4037:
4036:
4032:
4018:
4017:
4013:
4003:
4001:
3995:
3994:
3990:
3980:
3978:
3963:
3962:
3958:
3949:
3947:
3937:
3936:
3932:
3922:
3920:
3906:
3905:
3901:
3891:
3889:
3873:
3872:
3868:
3852:
3851:
3847:
3838:
3836:
3808:ACM SIGACT News
3797:
3796:
3792:
3783:
3781:
3778:The Denver Post
3772:
3771:
3767:
3751:
3750:
3746:
3736:
3734:
3725:
3724:
3720:
3703:Pick A (1892).
3702:
3701:
3697:
3678:Neurology Today
3675:
3674:
3670:
3640:
3639:
3635:
3591:
3590:
3586:
3576:
3574:
3565:
3564:
3560:
3530:
3529:
3525:
3487:
3486:
3482:
3450:10.1.1.527.3607
3434:
3433:
3426:
3390:
3389:
3380:
3336:
3335:
3331:
3287:
3286:
3282:
3238:
3237:
3226:
3213:
3209:
3173:
3172:
3168:
3130:
3129:
3125:
3089:
3088:
3084:
3046:
3045:
3041:
2995:
2994:
2990:
2960:
2959:
2955:
2911:
2910:
2906:
2870:
2869:
2865:
2821:
2820:
2816:
2772:
2771:
2767:
2731:
2730:
2726:
2682:
2681:
2677:
2635:
2634:
2630:
2586:
2585:
2581:
2545:
2544:
2540:
2495:Brain Pathology
2488:
2487:
2483:
2445:
2444:
2440:
2401:
2400:
2396:
2367:(11): 771–780.
2358:
2357:
2353:
2315:
2314:
2307:
2259:
2258:
2254:
2210:
2209:
2205:
2161:
2160:
2153:
2109:
2108:
2099:
2089:
2087:
2074:
2073:
2069:
2025:
2024:
2020:
1990:
1989:
1978:
1965:
1964:
1960:
1916:
1915:
1908:
1898:
1896:
1888:
1887:
1883:
1874:
1872:
1862:
1861:
1854:
1847:
1832:
1822:
1821:
1817:
1807:
1805:
1792:
1791:
1787:
1743:
1742:
1729:
1685:
1684:
1677:
1641:
1640:
1629:
1619:
1617:
1608:
1607:
1603:
1559:
1558:
1551:
1507:
1506:
1499:
1489:
1487:
1482:
1481:
1477:
1451:
1450:
1441:
1434:
1421:
1420:
1413:
1369:
1368:
1357:
1328:(10): 740–741.
1315:
1314:
1307:
1265:
1264:
1257:
1244:
1243:
1239:
1232:
1220:
1219:
1215:
1171:
1170:
1159:
1154:
1149:
1110:
1073:David Rumelhart
1003:Robert W. Floyd
935:
919:Alois Alzheimer
907:
893:
870:
786:
666:
624:
618:
566:in intron 1 of
492:
418:
410:
394:caudate nucleus
351:
340:
325:
286:
258:
218:
178:spindle neurons
155:Alois Alzheimer
106:), also called
63:atrophy of the
33:
28:
23:
22:
15:
12:
11:
5:
6697:
6695:
6687:
6686:
6681:
6676:
6671:
6661:
6660:
6654:
6653:
6650:
6649:
6646:
6645:
6643:
6642:
6641:
6640:
6629:
6628:
6627:
6626:
6625:
6624:
6619:
6609:
6604:
6603:
6602:
6597:
6592:
6591:
6590:
6585:
6580:
6572:
6567:
6562:
6557:
6552:
6542:
6528:
6527:
6526:
6525:
6520:
6515:
6501:
6499:
6493:
6492:
6490:
6489:
6484:
6478:
6476:
6467:
6458:
6454:
6453:
6450:
6449:
6447:
6446:
6441:
6436:
6431:
6426:
6421:
6415:
6413:
6409:
6408:
6406:
6405:
6400:
6398:Cerebral edema
6395:
6394:
6393:
6388:
6383:
6378:
6367:
6365:
6359:
6358:
6355:
6354:
6352:
6351:
6350:
6349:
6347:Template:Sleep
6337:
6335:
6331:
6330:
6328:
6327:
6321:
6316:
6310:
6308:
6302:
6301:
6299:
6298:
6292:
6287:
6282:
6276:
6274:
6268:
6267:
6265:
6264:
6258:
6253:
6248:
6242:
6240:
6227:
6219:
6218:
6216:
6215:
6209:
6204:
6199:
6193:
6191:
6185:
6184:
6181:
6180:
6178:
6177:
6175:Leigh syndrome
6171:
6169:
6163:
6162:
6160:
6159:
6148:
6147:
6142:
6137:
6136:
6135:
6121:
6120:
6119:
6114:
6113:
6112:
6096:
6094:
6088:
6087:
6085:
6084:
6079:
6074:
6073:
6072:
6067:
6056:
6055:
6054:
6053:
6048:
6047:
6046:
6036:
6035:
6034:
6024:
6019:
6018:
6017:
6012:
6007:
6002:
5986:
5985:
5984:
5983:
5978:
5973:
5968:
5963:
5962:
5961:
5951:
5950:
5949:
5939:
5938:
5937:
5932:
5927:
5911:
5909:
5902:Extrapyramidal
5895:
5886:
5884:encephalopathy
5875:
5874:
5871:
5870:
5868:
5867:
5862:
5857:
5856:
5855:
5844:
5842:
5835:
5834:
5832:
5831:
5830:
5829:
5819:
5814:
5813:
5812:
5807:
5802:
5797:
5786:
5784:
5775:
5769:
5768:
5761:nervous system
5758:
5756:
5755:
5748:
5741:
5733:
5724:
5723:
5720:
5719:
5717:
5716:
5711:
5706:
5701:
5695:
5692:
5691:
5688:
5681:
5680:
5677:
5676:
5673:
5672:
5670:
5669:
5663:
5661:
5657:
5656:
5654:
5653:
5648:
5643:
5638:
5632:
5630:
5626:
5625:
5623:
5622:
5617:
5612:
5606:
5604:
5595:
5594:
5592:
5591:
5586:
5580:
5578:
5570:
5569:
5556:
5549:
5548:
5545:
5544:
5542:
5541:
5536:
5531:
5526:
5524:Rebound effect
5521:
5516:
5511:
5505:
5502:
5501:
5491:
5484:
5483:
5480:
5479:
5476:
5475:
5473:
5472:
5467:
5465:Hypersexuality
5461:
5459:
5453:
5452:
5450:
5449:
5444:
5438:
5436:
5430:
5429:
5427:
5426:
5425:
5424:
5419:
5414:
5404:
5399:
5393:
5391:
5384:
5383:
5381:
5380:
5375:
5370:
5365:
5359:
5357:
5347:
5346:
5343:
5336:
5335:
5332:
5331:
5328:
5327:
5325:
5324:
5319:
5314:
5309:
5304:
5299:
5294:
5293:
5292:
5287:
5282:
5272:
5266:
5264:
5258:
5257:
5255:
5254:
5249:
5244:
5239:
5233:
5231:
5225:
5224:
5221:
5220:
5218:
5217:
5216:
5215:
5210:
5200:
5198:Panic disorder
5195:
5190:
5185:
5179:
5177:
5173:
5172:
5170:
5169:
5168:
5167:
5165:Claustrophobia
5157:
5156:
5155:
5150:
5148:Anthropophobia
5140:
5138:Social anxiety
5135:
5130:
5124:
5122:
5113:
5107:
5106:
5104:
5103:
5096:
5094:
5084:
5083:
5070:
5063:
5062:
5059:
5058:
5055:
5054:
5052:
5051:
5046:
5041:
5035:
5033:
5029:
5028:
5026:
5025:
5020:
5015:
5010:
5008:Pick's disease
5005:
5000:
4995:
4990:
4985:
4980:
4975:
4969:
4967:
4961:
4960:
4958:
4957:
4952:
4947:
4942:
4937:
4931:
4929:
4919:
4918:
4915:
4908:
4907:
4904:
4903:
4901:
4900:
4895:
4894:
4893:
4888:
4883:
4878:
4873:
4863:
4862:
4861:
4856:
4851:
4846:
4835:
4832:
4831:
4825:
4818:
4817:
4814:
4813:
4810:
4809:
4807:
4806:
4801:
4795:
4793:
4783:
4782:
4780:
4779:
4778:
4777:
4766:
4764:
4758:
4757:
4755:
4754:
4753:
4752:
4742:
4741:
4740:
4735:
4725:
4724:
4723:
4718:
4713:
4705:
4704:
4703:
4693:
4692:
4691:
4681:
4680:
4679:
4669:
4663:
4661:
4651:
4650:
4645:
4638:
4637:
4634:
4633:
4630:
4629:
4627:
4626:
4621:
4616:
4611:
4606:
4601:
4596:
4591:
4586:
4585:
4584:
4573:
4571:
4567:
4566:
4564:
4563:
4558:
4553:
4548:
4543:
4542:
4541:
4536:
4526:
4520:
4518:
4510:
4509:
4506:
4499:
4498:
4494:Classification
4488:
4486:
4485:
4478:
4471:
4463:
4454:
4453:
4450:
4449:
4438:
4426:
4425:
4423:
4419:
4418:
4415:
4414:
4403:
4392:
4375:
4360:
4345:
4329:
4324:
4323:
4321:
4320:Classification
4313:
4312:
4292:
4268:
4243:
4218:
4175:
4147:(5): 742–748.
4131:
4129:
4126:
4123:
4122:
4100:
4075:
4049:
4030:
4011:
3988:
3956:
3930:
3919:on 29 May 2015
3899:
3866:
3845:
3790:
3765:
3744:
3718:
3695:
3668:
3649:(6): 969–971.
3633:
3604:(5): 528–536.
3584:
3558:
3539:(5): 212–216.
3523:
3480:
3443:(6): 871–879.
3424:
3378:
3349:(5): 349–355.
3329:
3300:(5): 822–830.
3280:
3224:
3207:
3166:
3139:(3): 497–510.
3123:
3082:
3055:(3): 418–426.
3039:
2988:
2953:
2904:
2883:(4): 535–540.
2863:
2834:(3): 327–339.
2814:
2785:(3): 783–799.
2765:
2724:
2695:(6): 689–700.
2675:
2628:
2579:
2538:
2501:(4): 681–693.
2481:
2438:
2411:(4): 211–218.
2394:
2351:
2324:(3): 589–593.
2305:
2268:(5): 617–627.
2252:
2223:(6): 589–595.
2217:Neuropathology
2203:
2151:
2097:
2067:
2018:
1976:
1958:
1929:(2): 339–374.
1906:
1881:
1852:
1845:
1839:. p. 51.
1815:
1785:
1727:
1698:(5): 375–398.
1675:
1654:(2): 140–143.
1627:
1601:
1549:
1520:(3): 498–506.
1497:
1475:
1439:
1432:
1411:
1355:
1305:
1278:(2): 251–263.
1255:
1237:
1230:
1213:
1184:(2): 339–374.
1156:
1155:
1153:
1150:
1148:
1147:
1142:
1137:
1132:
1127:
1122:
1117:
1111:
1109:
1106:
1105:
1104:
1098:
1092:
1089:Wendy Williams
1086:
1079:
1070:
1061:
1052:
1046:
1040:
1030:
1024:
1018:
1012:
1006:
1000:
994:Buffalo Sabres
987:
981:Jerry Corbetta
978:
975:Sound of Music
968:
962:
956:
939:Pick's disease
934:
931:
915:Pick's disease
906:
903:
892:
889:
869:
866:
862:
861:
858:
855:
850:
847:
818:social emotion
785:
782:
770:
769:
764:
761:
752:
742:
736:
705:theory of mind
674:temporal lobes
665:
662:
620:Main article:
617:
614:
613:
612:
605:
598:
579:
536:
520:been described
491:
488:
473:rooting reflex
455:, a number of
449:working memory
417:
414:
409:
406:
350:
347:
339:
336:
324:
321:
290:Pick's disease
285:
282:
257:
254:
217:
214:
182:Pick's disease
151:Pick's disease
124:temporal lobes
95:
94:
89:
85:
84:
75:
69:
68:
49:
48:
40:
39:
31:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6696:
6685:
6684:Temporal lobe
6682:
6680:
6677:
6675:
6672:
6670:
6667:
6666:
6664:
6639:
6636:
6635:
6634:
6631:
6630:
6623:
6620:
6618:
6615:
6614:
6613:
6610:
6608:
6605:
6601:
6598:
6596:
6593:
6589:
6586:
6584:
6581:
6579:
6576:
6575:
6573:
6571:
6568:
6566:
6563:
6561:
6558:
6556:
6553:
6551:
6548:
6547:
6546:
6543:
6541:
6538:
6537:
6536:
6534:
6530:
6529:
6524:
6521:
6519:
6516:
6514:
6511:
6510:
6509:
6507:
6503:
6502:
6500:
6498:
6494:
6488:
6485:
6483:
6480:
6479:
6477:
6475:
6471:
6468:
6466:
6462:
6459:
6455:
6445:
6442:
6440:
6437:
6435:
6432:
6430:
6427:
6425:
6424:Reye syndrome
6422:
6420:
6417:
6416:
6414:
6410:
6404:
6401:
6399:
6396:
6392:
6389:
6387:
6384:
6382:
6379:
6377:
6376:Hydrocephalus
6374:
6373:
6372:
6369:
6368:
6366:
6364:
6360:
6348:
6344:
6343:
6342:
6339:
6338:
6336:
6332:
6326:
6322:
6320:
6317:
6315:
6312:
6311:
6309:
6307:
6303:
6297:
6293:
6291:
6288:
6286:
6283:
6281:
6278:
6277:
6275:
6273:
6269:
6263:
6259:
6257:
6254:
6252:
6249:
6247:
6244:
6243:
6241:
6239:
6235:
6231:
6228:
6226:
6220:
6214:
6210:
6208:
6205:
6203:
6200:
6198:
6195:
6194:
6192:
6190:
6189:Demyelinating
6186:
6176:
6173:
6172:
6170:
6168:
6164:
6158:
6155:
6154:
6153:
6152:
6146:
6143:
6141:
6138:
6134:
6131:
6130:
6129:
6125:
6122:
6118:
6115:
6111:
6108:
6107:
6106:
6103:
6102:
6101:
6098:
6097:
6095:
6093:
6089:
6083:
6080:
6078:
6077:Restless legs
6075:
6071:
6068:
6066:
6063:
6062:
6061:
6058:
6057:
6052:
6049:
6045:
6042:
6041:
6040:
6037:
6033:
6030:
6029:
6028:
6025:
6023:
6020:
6016:
6015:Blepharospasm
6013:
6011:
6008:
6006:
6003:
6001:
5998:
5997:
5996:
5993:
5992:
5991:
5988:
5987:
5982:
5979:
5977:
5974:
5972:
5971:Hemiballismus
5969:
5967:
5964:
5960:
5957:
5956:
5955:
5952:
5948:
5945:
5944:
5943:
5940:
5936:
5933:
5931:
5928:
5926:
5923:
5922:
5921:
5918:
5917:
5916:
5913:
5912:
5910:
5908:
5903:
5899:
5896:
5894:
5890:
5887:
5885:
5880:
5876:
5866:
5863:
5861:
5858:
5854:
5851:
5850:
5849:
5846:
5845:
5843:
5841:
5836:
5828:
5825:
5824:
5823:
5822:Brain abscess
5820:
5818:
5815:
5811:
5808:
5806:
5803:
5801:
5798:
5796:
5793:
5792:
5791:
5788:
5787:
5785:
5783:
5779:
5776:
5774:
5770:
5766:
5762:
5754:
5749:
5747:
5742:
5740:
5735:
5734:
5731:
5715:
5712:
5710:
5707:
5705:
5702:
5700:
5697:
5696:
5693:
5686:
5682:
5668:
5665:
5664:
5662:
5658:
5652:
5649:
5647:
5644:
5642:
5639:
5637:
5634:
5633:
5631:
5629:Schizophrenia
5627:
5621:
5618:
5616:
5613:
5611:
5608:
5607:
5605:
5600:
5596:
5590:
5587:
5585:
5582:
5581:
5579:
5575:
5571:
5567:
5563:
5559:
5558:Schizophrenia
5554:
5550:
5540:
5537:
5535:
5532:
5530:
5527:
5525:
5522:
5520:
5517:
5515:
5512:
5510:
5509:Drug overdose
5507:
5506:
5503:
5498:
5494:
5489:
5485:
5471:
5468:
5466:
5463:
5462:
5460:
5458:
5457:Sexual desire
5454:
5448:
5445:
5443:
5440:
5439:
5437:
5435:
5431:
5423:
5420:
5418:
5415:
5413:
5410:
5409:
5408:
5405:
5403:
5400:
5398:
5395:
5394:
5392:
5390:
5385:
5379:
5376:
5374:
5371:
5369:
5366:
5364:
5361:
5360:
5358:
5356:
5352:
5348:
5341:
5337:
5323:
5320:
5318:
5315:
5313:
5310:
5308:
5305:
5303:
5300:
5298:
5295:
5291:
5288:
5286:
5283:
5281:
5278:
5277:
5276:
5273:
5271:
5268:
5267:
5265:
5263:
5259:
5253:
5250:
5248:
5245:
5243:
5240:
5238:
5235:
5234:
5232:
5230:
5226:
5214:
5211:
5209:
5206:
5205:
5204:
5201:
5199:
5196:
5194:
5191:
5189:
5186:
5184:
5181:
5180:
5178:
5174:
5166:
5163:
5162:
5161:
5158:
5154:
5151:
5149:
5146:
5145:
5144:
5143:Social phobia
5141:
5139:
5136:
5134:
5131:
5129:
5126:
5125:
5123:
5121:
5117:
5114:
5112:
5108:
5101:
5098:
5097:
5095:
5093:
5089:
5085:
5081:
5078:-related and
5077:
5073:
5068:
5064:
5050:
5047:
5045:
5042:
5040:
5037:
5036:
5034:
5030:
5024:
5021:
5019:
5016:
5014:
5011:
5009:
5006:
5004:
5001:
4999:
4996:
4994:
4991:
4989:
4986:
4984:
4981:
4979:
4976:
4974:
4971:
4970:
4968:
4966:
4962:
4956:
4953:
4951:
4948:
4946:
4943:
4941:
4938:
4936:
4933:
4932:
4930:
4928:
4924:
4920:
4913:
4909:
4899:
4896:
4892:
4889:
4887:
4884:
4882:
4879:
4877:
4874:
4872:
4869:
4868:
4867:
4864:
4860:
4857:
4855:
4852:
4850:
4847:
4845:
4842:
4841:
4840:
4837:
4836:
4833:
4828:
4823:
4819:
4805:
4802:
4800:
4797:
4796:
4794:
4791:
4784:
4776:
4773:
4772:
4771:
4768:
4767:
4765:
4763:
4759:
4751:
4748:
4747:
4746:
4743:
4739:
4736:
4734:
4731:
4730:
4729:
4726:
4722:
4719:
4717:
4714:
4712:
4709:
4708:
4706:
4702:
4699:
4698:
4697:
4694:
4690:
4687:
4686:
4685:
4682:
4678:
4675:
4674:
4673:
4670:
4668:
4665:
4664:
4662:
4660:
4656:
4652:
4648:
4643:
4639:
4625:
4622:
4620:
4617:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4597:
4595:
4592:
4590:
4587:
4583:
4580:
4579:
4578:
4575:
4574:
4572:
4568:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4540:
4537:
4535:
4532:
4531:
4530:
4527:
4525:
4522:
4521:
4519:
4515:
4511:
4504:
4500:
4495:
4491:
4484:
4479:
4477:
4472:
4470:
4465:
4464:
4461:
4448:
4444:
4443:
4439:
4437:
4433:
4432:
4428:
4427:
4424:
4420:
4413:
4409:
4408:
4404:
4402:
4398:
4397:
4393:
4391:
4388:
4385:
4381:
4380:
4376:
4374:
4370:
4369:
4365:
4361:
4359:
4355:
4354:
4350:
4346:
4344:
4340:
4339:
4335:
4331:
4330:
4327:
4322:
4318:
4302:
4298:
4293:
4283:on 2018-02-20
4282:
4278:
4274:
4269:
4265:
4261:
4257:
4253:
4251:
4244:
4240:
4236:
4232:
4228:
4226:
4219:
4215:
4211:
4206:
4201:
4197:
4193:
4189:
4185:
4181:
4176:
4172:
4168:
4163:
4158:
4154:
4150:
4146:
4142:
4138:
4133:
4132:
4127:
4118:
4114:
4110:
4104:
4101:
4090:
4086:
4079:
4076:
4064:
4060:
4053:
4050:
4045:
4041:
4034:
4031:
4026:
4022:
4015:
4012:
3999:
3992:
3989:
3976:
3972:
3971:
3966:
3960:
3957:
3946:on 2013-05-03
3945:
3941:
3934:
3931:
3918:
3914:
3910:
3903:
3900:
3887:
3883:
3882:
3877:
3870:
3867:
3862:
3861:
3856:
3849:
3846:
3835:on 2017-04-22
3834:
3830:
3826:
3822:
3818:
3814:
3810:
3809:
3804:
3800:
3794:
3791:
3779:
3775:
3769:
3766:
3761:
3760:
3755:
3748:
3745:
3733:
3729:
3722:
3719:
3714:
3710:
3706:
3699:
3696:
3691:
3687:
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3679:
3672:
3669:
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3660:
3656:
3652:
3648:
3644:
3637:
3634:
3629:
3625:
3620:
3615:
3611:
3607:
3603:
3599:
3595:
3588:
3585:
3572:
3568:
3562:
3559:
3554:
3550:
3546:
3542:
3538:
3534:
3527:
3524:
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3511:
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3503:
3499:
3495:
3491:
3484:
3481:
3476:
3472:
3468:
3464:
3460:
3456:
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3442:
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3429:
3425:
3420:
3416:
3411:
3406:
3402:
3398:
3394:
3387:
3385:
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3379:
3374:
3370:
3365:
3360:
3356:
3352:
3348:
3344:
3340:
3333:
3330:
3325:
3321:
3316:
3311:
3307:
3303:
3299:
3295:
3291:
3284:
3281:
3276:
3272:
3267:
3262:
3258:
3254:
3250:
3246:
3242:
3235:
3233:
3231:
3229:
3225:
3222:
3218:
3217:
3211:
3208:
3203:
3199:
3194:
3189:
3185:
3181:
3177:
3170:
3167:
3162:
3158:
3154:
3150:
3146:
3142:
3138:
3134:
3127:
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3119:
3115:
3110:
3105:
3101:
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3078:
3074:
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3050:
3043:
3040:
3035:
3031:
3026:
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3011:
3007:
3003:
2999:
2992:
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2980:
2976:
2972:
2968:
2964:
2957:
2954:
2949:
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2940:
2935:
2931:
2927:
2923:
2919:
2915:
2908:
2905:
2900:
2896:
2891:
2886:
2882:
2878:
2874:
2867:
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2859:
2855:
2850:
2845:
2841:
2837:
2833:
2829:
2825:
2818:
2815:
2810:
2806:
2801:
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2784:
2780:
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2679:
2676:
2671:
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2663:
2659:
2655:
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2647:
2643:
2639:
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2500:
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2422:
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2362:
2355:
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2256:
2253:
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2240:
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2222:
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2214:
2207:
2204:
2199:
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2138:
2133:
2129:
2125:
2121:
2117:
2113:
2106:
2104:
2102:
2098:
2086:
2082:
2078:
2077:"Pick bodies"
2071:
2068:
2063:
2059:
2054:
2049:
2045:
2041:
2037:
2033:
2029:
2022:
2019:
2014:
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1987:
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1983:
1981:
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1968:
1962:
1959:
1954:
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1932:
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1920:
1913:
1911:
1907:
1895:
1891:
1885:
1882:
1871:
1870:
1865:
1859:
1857:
1853:
1848:
1846:92-4-154422-8
1842:
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1795:
1789:
1786:
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1593:
1588:
1583:
1579:
1575:
1571:
1567:
1563:
1556:
1554:
1550:
1545:
1541:
1536:
1531:
1527:
1523:
1519:
1515:
1511:
1504:
1502:
1498:
1485:
1479:
1476:
1471:
1467:
1463:
1459:
1455:
1448:
1446:
1444:
1440:
1435:
1429:
1425:
1418:
1416:
1412:
1407:
1403:
1398:
1393:
1389:
1385:
1381:
1377:
1373:
1366:
1364:
1362:
1360:
1356:
1351:
1347:
1343:
1339:
1335:
1331:
1327:
1323:
1319:
1312:
1310:
1306:
1301:
1297:
1293:
1289:
1285:
1281:
1277:
1273:
1269:
1262:
1260:
1256:
1251:
1247:
1241:
1238:
1233:
1227:
1223:
1217:
1214:
1209:
1205:
1200:
1195:
1191:
1187:
1183:
1179:
1175:
1168:
1166:
1164:
1162:
1158:
1151:
1146:
1143:
1141:
1140:Transportin 1
1138:
1136:
1133:
1131:
1128:
1126:
1123:
1121:
1118:
1116:
1113:
1112:
1107:
1102:
1099:
1096:
1093:
1090:
1087:
1084:
1083:Nicholas Wall
1080:
1078:
1074:
1071:
1069:
1065:
1062:
1060:
1056:
1053:
1050:
1047:
1044:
1041:
1038:
1034:
1031:
1028:
1025:
1022:
1019:
1016:
1013:
1011:
1007:
1004:
1001:
998:
995:
992:(1935–1996),
991:
988:
986:
982:
979:
976:
972:
971:Charmian Carr
969:
966:
963:
960:
957:
955:
951:
950:hardcore punk
947:
944:
943:
942:
940:
933:Notable cases
932:
930:
927:
922:
920:
916:
912:
904:
902:
900:
896:
890:
888:
885:
883:
879:
875:
867:
865:
859:
856:
854:
851:
848:
846:
845:Faux Pas test
843:
842:
841:
839:
833:
829:
827:
822:
819:
813:
811:
807:
802:
799:
795:
791:
783:
781:
779:
774:
768:
765:
762:
760:
756:
755:Perseverative
753:
751:
747:
743:
740:
737:
735:
734:Disinhibition
732:
731:
730:
726:
723:
717:
715:
710:
706:
701:
699:
695:
691:
687:
683:
677:
675:
671:
663:
661:
659:
655:
651:
649:
645:
641:
636:
634:
630:
623:
615:
610:
606:
603:
599:
596:
592:
588:
584:
580:
577:
573:
569:
565:
561:
557:
553:
549:
545:
541:
537:
534:
530:
525:
521:
517:
513:
509:
505:
502:Tau-positive
501:
500:
499:
497:
489:
487:
485:
481:
476:
474:
470:
466:
462:
458:
454:
450:
446:
441:
439:
435:
431:
427:
423:
415:
413:
407:
405:
403:
399:
395:
391:
390:basal ganglia
387:
383:
379:
378:proteopathies
376:
372:
368:
364:
360:
356:
348:
346:
344:
337:
335:
333:
329:
322:
320:
318:
314:
310:
307:found in the
306:
301:
299:
295:
291:
283:
281:
279:
275:
271:
267:
263:
255:
253:
251:
247:
243:
239:
234:
232:
228:
224:
215:
213:
211:
207:
203:
199:
195:
191:
187:
183:
179:
175:
171:
166:
164:
160:
159:disinhibition
156:
152:
148:
143:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
93:
90:
86:
83:
79:
76:
74:
70:
66:
65:frontal lobes
62:
58:
54:
50:
46:
41:
36:
30:
19:
6679:Frontal lobe
6632:
6531:
6504:
6465:Degenerative
6202:Inflammatory
6149:
6123:
6082:Stiff-person
5920:Parkinsonism
5893:Degenerative
5790:Encephalitis
5773:Inflammation
5763:, primarily
5589:Folie Ă deux
5514:Intoxication
5495:substances,
5493:Psychoactive
5412:Night terror
5229:Dissociative
5193:Panic attack
4987:
4745:Tic disorder
4440:
4429:
4405:
4394:
4377:
4362:
4347:
4332:
4306:17 September
4304:. Retrieved
4300:
4285:. Retrieved
4281:the original
4276:
4271:Reynolds M.
4255:
4249:
4230:
4224:
4187:
4183:
4144:
4140:
4117:the original
4112:
4103:
4092:. Retrieved
4088:
4078:
4066:. Retrieved
4062:
4052:
4043:
4033:
4025:www.wbur.org
4024:
4014:
4002:. Retrieved
3991:
3979:. Retrieved
3975:the original
3970:The Sentinel
3968:
3959:
3948:. Retrieved
3944:the original
3938:Sportsteam.
3933:
3921:. Retrieved
3917:the original
3912:
3902:
3890:. Retrieved
3886:the original
3879:
3869:
3858:
3848:
3837:. Retrieved
3833:the original
3812:
3806:
3793:
3782:. Retrieved
3780:. 2016-09-20
3777:
3768:
3757:
3747:
3735:. Retrieved
3731:
3721:
3712:
3708:
3698:
3684:(9): 35–36.
3681:
3677:
3671:
3646:
3642:
3636:
3601:
3597:
3587:
3575:. Retrieved
3570:
3561:
3536:
3532:
3526:
3493:
3489:
3483:
3440:
3436:
3400:
3396:
3346:
3342:
3332:
3297:
3293:
3283:
3248:
3244:
3214:
3210:
3183:
3179:
3169:
3136:
3132:
3126:
3099:
3095:
3085:
3052:
3048:
3042:
3005:
3001:
2991:
2969:(2): 70–72.
2966:
2962:
2956:
2921:
2917:
2907:
2880:
2876:
2866:
2831:
2827:
2817:
2782:
2778:
2768:
2741:
2737:
2727:
2692:
2688:
2678:
2645:
2641:
2631:
2596:
2592:
2582:
2555:
2551:
2541:
2498:
2494:
2484:
2451:
2447:
2441:
2408:
2404:
2397:
2364:
2360:
2354:
2321:
2317:
2265:
2261:
2255:
2220:
2216:
2206:
2171:
2167:
2119:
2115:
2088:. Retrieved
2080:
2075:Gaillard F.
2070:
2035:
2031:
2021:
1999:(1): 71–88.
1996:
1992:
1970:
1961:
1926:
1922:
1897:. Retrieved
1893:
1884:
1873:. Retrieved
1867:
1828:
1818:
1806:. Retrieved
1802:the original
1797:
1788:
1753:
1749:
1695:
1691:
1651:
1647:
1618:. Retrieved
1614:
1604:
1569:
1565:
1517:
1513:
1488:. Retrieved
1478:
1461:
1457:
1423:
1379:
1375:
1325:
1321:
1275:
1271:
1249:
1240:
1221:
1216:
1181:
1177:
1095:Bruce Willis
1015:Colleen Howe
974:
965:Don Cardwell
959:Clancy Blair
954:Beastie Boys
938:
936:
925:
923:
914:
908:
897:
894:
886:
871:
863:
837:
834:
830:
823:
814:
803:
787:
775:
771:
763:Hyperorality
727:
718:
713:
702:
678:
667:
652:
637:
625:
493:
477:
469:palmar grasp
442:
422:binge eating
419:
411:
352:
341:
326:
302:
289:
287:
259:
235:
219:
200:(NIFID) and
192:(svPPA) and
181:
167:
150:
144:
111:
107:
103:
99:
98:
61:white matter
29:
6617:Fazio–Londe
6457:Both/either
6251:Generalised
6110:Early-onset
6105:Alzheimer's
5840:spinal cord
5562:schizotypal
5397:Hypersomnia
5387:Nonorganic
5128:Agoraphobia
4859:Cyclothymia
4854:Bipolar NOS
4829:(affective)
4701:Stereotypic
4609:Kleptomania
4442:GeneReviews
4256:GeneReviews
4231:GeneReviews
4068:22 February
3907:Farooq MO.
3815:(4): 3–13.
2648:(1): 6–18.
2085:Radiopaedia
1869:Dementia UK
1824:Sartorius N
1615:Smithsonian
1572:: 469–495.
1250:icd.who.int
1135:Proteopathy
1043:Kevin Moore
1033:Ralph Klein
1027:Terry Jones
990:Ted Darling
911:Arnold Pick
882:cholinergic
512:tau protein
471:reflex and
359:cytoplasmic
246:behavioural
147:Arnold Pick
18:Pick bodies
6663:Categories
6225:paroxysmal
6197:Autoimmune
5990:Dyskinesia
5860:Meningitis
5838:Brain and
5714:Stereotypy
5577:Delusional
5566:delusional
5539:Withdrawal
5407:Parasomnia
5312:Nosophobia
5092:Adjustment
5080:somatoform
5013:Sundowning
4866:Depression
4849:Bipolar II
4738:Stuttering
4733:Cluttering
4529:Paraphilia
4431:Patient UK
4407:DiseasesDB
4287:2018-02-19
4094:2023-02-16
4004:22 January
3981:11 October
3950:2013-04-29
3913:nazrul.org
3892:October 3,
3839:2020-12-12
3784:2016-10-29
3715:: 165–167.
3577:30 October
3133:NeuroImage
3008:: 784361.
2744:: 102669.
2738:DNA Repair
2283:2429/54671
1899:1 November
1875:2020-10-19
1620:30 October
1382:(2): 169.
1152:References
1101:Mark Wirtz
1055:Nic Potter
1049:Ernie Moss
1010:Cloudflare
997:television
946:John Berry
868:Management
849:Hotel task
654:DNA damage
78:Psychiatry
6222:Episodic/
6100:Tauopathy
6051:Akathisia
6039:Myoclonus
6022:Athetosis
5954:Tauopathy
5667:Catatonia
5599:Psychosis
5434:Postnatal
5417:Nightmare
5023:Wandering
4876:Dysthymia
4844:Bipolar I
4799:Pervasive
4614:Pyromania
4539:Voyeurism
4534:Fetishism
4141:Neurology
3445:CiteSeerX
3343:Neurology
2448:Neurology
2116:Neurology
1750:Continuum
1692:CNS Drugs
1342:0035-3787
999:announcer
985:Sugarloaf
921:in 1911.
891:Prognosis
741:/ Inertia
696:, as the
664:Diagnosis
616:Pathology
529:megabases
482:(ALS), a
459:known as
313:ubiquitin
309:cytoplasm
294:apathetic
223:prevalent
194:nonfluent
140:off-label
128:prevalent
82:neurology
73:Specialty
53:Brain MRI
6674:Dementia
6588:SMALED2B
6583:SMALED2A
6280:Migraine
6272:Headache
6238:epilepsy
6234:Seizures
6092:Dementia
5995:Dystonia
5402:Insomnia
5072:Neurotic
5039:Delirium
4965:Dementia
4804:Specific
4264:20301678
4239:20301545
4214:14570833
4171:15007124
3923:26 March
3829:35605565
3799:Knuth DE
3732:Elsevier
3663:15210543
3628:22847063
3475:13590871
3467:16839295
3419:19336463
3373:19652138
3324:33226735
3275:21810890
3202:11708991
3153:17478101
3118:10430832
3069:17140704
3034:34975400
2983:24394289
2948:21908872
2899:17420315
2858:33386471
2809:32185393
2760:31331820
2719:23160421
2670:58636022
2662:30582889
2623:33004675
2574:16543401
2533:10711305
2525:10517507
2476:11672234
2468:16344521
2433:46800951
2425:14665820
2389:17310802
2381:16239184
2346:24125998
2338:21584651
2300:22541167
2292:19830439
2247:19275295
2239:24673472
2198:21792670
2146:15505152
2090:12 March
2062:26595641
2013:20415586
1953:28410663
1780:27042904
1722:20369906
1670:11823324
1596:30355151
1544:34338439
1490:23 March
1470:21121521
1406:12531941
1350:81923630
1300:88481297
1292:30925617
1208:28410663
1130:Mini-SEA
1108:See also
1039:, Canada
746:Sympathy
744:Loss of
609:TMEM106B
490:Genetics
434:striatum
386:striatum
332:semantic
225:type of
190:semantic
174:neuronal
130:type of
116:dementia
57:Cortical
6600:SMA-PME
6595:SMA-PCH
6578:SMALED1
6290:Tension
6285:Cluster
6010:Meige's
5827:Amoebic
5111:Anxiety
4950:PDD-NOS
4839:Bipolar
4492: (
4401:D003704
4205:1757381
4162:2367136
4089:Variety
3619:3443960
3553:9184615
3518:1841280
3510:8941953
3364:2725928
3315:8119305
3266:3170532
3077:9039002
3025:8716463
2939:3170537
2849:8049516
2800:7089666
2710:3923493
2614:7818661
2593:Science
2516:8098140
2189:3199334
2137:3516854
2053:5970949
1944:5472209
1808:3 March
1771:5390934
1713:2916644
1587:6731550
1535:9291221
1397:1738259
1199:5472209
905:History
750:Empathy
714:in vivo
670:frontal
640:C9orf72
629:autopsy
568:C9ORF72
388:in the
382:Imaging
373:(FTLD)-
317:tubulin
280:(PSP).
270:FTD–ALS
212:(ALS).
188:(PPA):
120:frontal
6319:Stroke
6133:Pick's
6060:Tremor
6027:Chorea
5355:Eating
5203:Stress
5120:Phobia
5076:stress
4935:Autism
4728:Speech
4517:Sexual
4390:614260
4387:105550
4384:600274
4373:331.19
4262:
4237:
4212:
4202:
4169:
4159:
3827:
3737:10 May
3661:
3626:
3616:
3551:
3516:
3508:
3473:
3465:
3447:
3417:
3371:
3361:
3322:
3312:
3273:
3263:
3200:
3161:130161
3159:
3151:
3116:
3075:
3067:
3032:
3022:
2981:
2946:
2936:
2897:
2856:
2846:
2807:
2797:
2758:
2717:
2707:
2668:
2660:
2621:
2611:
2572:
2531:
2523:
2513:
2474:
2466:
2431:
2423:
2387:
2379:
2344:
2336:
2298:
2290:
2245:
2237:
2196:
2186:
2144:
2134:
2060:
2050:
2032:Lancet
2011:
1951:
1941:
1843:
1778:
1768:
1720:
1710:
1668:
1594:
1584:
1542:
1532:
1468:
1430:
1404:
1394:
1348:
1340:
1298:
1290:
1228:
1206:
1196:
739:Apathy
591:SQSTM1
576:TDP-43
572:TARDBP
436:, and
430:insula
242:mental
229:after
134:after
88:Causes
6633:both:
6565:DSMA1
6560:SMAX2
6555:SMAX1
6535:only:
6508:only:
6412:Other
6334:Other
6246:Focal
5879:Brain
5782:Brain
5660:Other
5389:sleep
5176:Other
5032:Other
4898:Mania
4570:Other
4412:10034
4358:G31.0
4301:Wired
4143:. 5.
3860:Wired
3825:S2CID
3514:S2CID
3471:S2CID
3397:Brain
3245:Brain
3157:S2CID
3096:Brain
3073:S2CID
2918:Brain
2779:Brain
2666:S2CID
2552:Brain
2529:S2CID
2472:S2CID
2429:S2CID
2385:S2CID
2342:S2CID
2296:S2CID
2243:S2CID
1833:(PDF)
1346:S2CID
1296:S2CID
574:(the
402:sulci
6236:and
5947:PKAN
5942:NBIA
5564:and
5213:PTSD
4827:Mood
4667:ADHD
4396:MeSH
4379:OMIM
4368:9-CM
4343:6D83
4308:2020
4260:PMID
4250:MAPT
4235:PMID
4210:PMID
4167:PMID
4070:2024
4063:TIME
4006:2013
3983:2014
3925:2016
3894:2015
3739:2022
3659:PMID
3624:PMID
3579:2015
3549:PMID
3506:PMID
3463:PMID
3415:PMID
3369:PMID
3320:PMID
3271:PMID
3198:PMID
3149:PMID
3114:PMID
3065:PMID
3030:PMID
2979:PMID
2944:PMID
2895:PMID
2854:PMID
2805:PMID
2756:PMID
2715:PMID
2658:PMID
2619:PMID
2570:PMID
2521:PMID
2464:PMID
2421:PMID
2377:PMID
2334:PMID
2288:PMID
2235:PMID
2194:PMID
2142:PMID
2092:2021
2058:PMID
2009:PMID
1949:PMID
1901:2020
1841:ISBN
1810:2021
1776:PMID
1718:PMID
1666:PMID
1622:2015
1592:PMID
1540:PMID
1492:2024
1466:PMID
1428:ISBN
1402:PMID
1338:ISSN
1288:PMID
1226:ISBN
1204:PMID
1081:Sir
672:and
648:MAPT
646:and
595:TBK1
593:and
587:OPTN
583:CYLD
524:glia
447:and
398:gyri
315:and
244:and
236:The
122:and
59:and
6550:SMA
6533:LMN
6506:UMN
6497:MND
6363:CSF
6314:TIA
5959:PSP
5935:NMS
5904:and
5765:CNS
5601:and
5188:OCD
4716:RAD
4711:DAD
4677:ODD
4364:ICD
4349:ICD
4334:ICD
4225:GRN
4200:PMC
4192:doi
4157:PMC
4149:doi
3817:doi
3686:doi
3651:doi
3614:PMC
3606:doi
3541:doi
3498:doi
3494:351
3455:doi
3405:doi
3401:132
3359:PMC
3351:doi
3310:PMC
3302:doi
3261:PMC
3253:doi
3249:134
3188:doi
3141:doi
3104:doi
3100:122
3057:doi
3020:PMC
3010:doi
2971:doi
2934:PMC
2926:doi
2922:134
2885:doi
2844:PMC
2836:doi
2832:141
2795:PMC
2787:doi
2783:143
2746:doi
2705:PMC
2697:doi
2650:doi
2609:PMC
2601:doi
2597:370
2560:doi
2556:129
2511:PMC
2503:doi
2456:doi
2413:doi
2369:doi
2326:doi
2278:hdl
2270:doi
2266:118
2225:doi
2184:PMC
2176:doi
2172:118
2132:PMC
2124:doi
2048:PMC
2040:doi
2036:386
2001:doi
1939:PMC
1931:doi
1766:PMC
1758:doi
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