310:
287:
184:
209:
568:
561:
316:
215:
4358:
3582:
Fressart V, Duthoit G, Donal E, Probst V, Deharo JC, Chevalier P, Klug D, Dubourg O, Delacretaz E, Cosnay P, Scanu P, Extramiana F, Keller D, Hidden-Lucet F, Simon F, Bessirard V, Roux-Buisson N, Hebert JL, Azarine A, Casset-Senon D, Rouzet F, Lecarpentier Y, Fontaine G, Coirault C, Frank R, Hainque
4232:
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T,
2097:
Groeneweg JA, Ummels A, Mulder M, Bikker H, van der Smagt JJ, van Mil AM, Homfray T, Post JG, Elvan A, van der
Heijden JF, Houweling AC, Jongbloed JD, Wilde AA, van Tintelen JP, Hauer RN, Dooijes D (November 2014). "Functional assessment of potential splice site variants in arrhythmogenic right
1434:
Plakophilin-2 over time has shown to be more than components of cell-cell junctions; rather the plakophilins are emerging as versatile scaffolds for various signaling pathways that more globally modulate diverse cellular activities. Plakophilin-2 has shown to localize to nuclei, in addition to
3286:
Cox MG, van der Zwaag PA, van der Werf C, van der Smagt JJ, Noorman M, Bhuiyan ZA, Wiesfeld AC, Volders PG, van Langen IM, Atsma DE, Dooijes D, van den
Wijngaard A, Houweling AC, Jongbloed JD, Jordaens L, Cramer MJ, Doevendans PA, de Bakker JM, Wilde AA, van Tintelen JP, Hauer RN (June 2011).
59:
3328:
Lahtinen AM, Lehtonen E, Marjamaa A, Kaartinen M, Heliö T, Porthan K, Oikarinen L, Toivonen L, Swan H, Jula A, Peltonen L, Palotie A, Salomaa V, Kontula K (August 2011). "Population-prevalent desmosomal mutations predisposing to arrhythmogenic right ventricular cardiomyopathy".
3546:
Bauce B, Nava A, Beffagna G, Basso C, Lorenzon A, Smaniotto G, De
Bortoli M, Rigato I, Mazzotti E, Steriotis A, Marra MP, Towbin JA, Thiene G, Danieli GA, Rampazzo A (January 2010). "Multiple mutations in desmosomal proteins encoding genes in arrhythmogenic right ventricular
2905:
Gerull B, Heuser A, Wichter T, Paul M, Basson CT, McDermott DA, Lerman BB, Markowitz SM, Ellinor PT, MacRae CA, Peters S, Grossmann KS, Drenckhahn J, Michely B, Sasse-Klaassen S, Birchmeier W, Dietz R, Breithardt G, Schulze-Bahr E, Thierfelder L (November 2004).
2729:
Zhou X, Chen M, Song H, Wang B, Chen H, Wang J, Wang W, Feng S, Zhang F, Ju W, Li M, Gu K, Cao K, Wang DW, Yang B (April 2015). "Comprehensive analysis of desmosomal gene mutations in Han
Chinese patients with arrhythmogenic right ventricular cardiomyopathy".
3289:"Arrhythmogenic right ventricular dysplasia/cardiomyopathy: pathogenic desmosome mutations in index-patients predict outcome of family screening: Dutch arrhythmogenic right ventricular dysplasia/cardiomyopathy genotype-phenotype follow-up study"
2999:
Kannankeril PJ, Bhuiyan ZA, Darbar D, Mannens MM, Wilde AA, Roden DM (August 2006). "Arrhythmogenic right ventricular cardiomyopathy due to a novel plakophilin 2 mutation: wide spectrum of disease in mutation carriers within a family".
2765:
Li Mura IE, Bauce B, Nava A, Fanciulli M, Vazza G, Mazzotti E, Rigato I, De
Bortoli M, Beffagna G, Lorenzon A, Calore M, Dazzo E, Nobile C, Mostacciuolo ML, Corrado D, Basso C, Daliento L, Thiene G, Rampazzo A (November 2013).
3070:
van
Tintelen JP, Entius MM, Bhuiyan ZA, Jongbloed R, Wiesfeld AC, Wilde AA, van der Smagt J, Boven LG, Mannens MM, van Langen IM, Hofstra RM, Otterspoor LC, Doevendans PA, Rodriguez LM, van Gelder IC, Hauer RN (April 2006).
3204:"Arrhythmogenic right ventricular cardiomyopathy caused by deletions in plakophilin-2 and plakoglobin (Naxos disease) in families from Greece and Cyprus: genotype-phenotype relations, diagnostic features and prognosis"
3993:
Bonné S, van Hengel J, van Roy F (2000). "Assignment of the plakophilin-2 gene (PKP2) and a plakophilin-2 pseudogene (PKP2P1) to human chromosome bands 12p11 and 12p13, respectively, by in situ hybridization".
1529:
in cardiac cells, which was coordinate with decreased electrical coupling of cells and decreased adhesion strength. These studies were further supported by an investigation in a mouse model harboring a
2856:
van der Zwaag PA, Cox MG, van der Werf C, Wiesfeld AC, Jongbloed JD, Dooijes D, Bikker H, Jongbloed R, Suurmeijer AJ, van den Berg MP, Hofstra RM, Hauer RN, Wilde AA, van
Tintelen JP (December 2010).
3035:
Lahtinen AM, Lehtonen A, Kaartinen M, Toivonen L, Swan H, Widén E, Lehtonen E, Lehto VP, Kontula K (May 2008). "Plakophilin-2 missense mutations in arrhythmogenic right ventricular cardiomyopathy".
3714:
Cerrone M, Lin X, Zhang M, Agullo-Pascual E, Pfenniger A, Chkourko Gusky H, Novelli V, Kim C, Tirasawadichai T, Judge DP, Rothenberg E, Chen HS, Napolitano C, Priori SG, Delmar M (March 2014).
3405:
van
Tintelen JP, Hofstra RM, Wiesfeld AC, van den Berg MP, Hauer RN, Jongbloed JD (May 2007). "Molecular genetics of arrhythmogenic right ventricular cardiomyopathy: emerging horizon?".
4031:
Hofmann I, Mertens C, Brettel M, Nimmrich V, Schnölzer M, Herrmann H (2000). "Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis".
3497:
den Haan AD, Tan BY, Zikusoka MN, Lladó LI, Jain R, Daly A, Tichnell C, James C, Amat-Alarcon N, Abraham T, Russell SD, Bluemke DA, Calkins H, Dalal D, Judge DP (October 2009).
3366:"Clinical and genetic characterization of families with arrhythmogenic right ventricular dysplasia/cardiomyopathy provides novel insights into patterns of disease expression"
1443:. Studies have shown that plakkophillin-2 is found in the nucleoplasm, complexed in the RNA polymerase III holoenzyme with the largest subunit of RNA polymerase III, termed
4146:
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004).
323:
222:
4276:
Dalal D, Molin LH, Piccini J, Tichnell C, James C, Bomma C, Prakasa K, Towbin JA, Marcus FI, Spevak PJ, Bluemke DA, Abraham T, Russell SD, Calkins H, Judge DP (2006).
2012:
3665:
Brun F, Barnes CV, Sinagra G, Slavov D, Barbati G, Zhu X, Graw SL, Spezzacatene A, Pinamonti B, Merlo M, Salcedo EE, Sauer WH, Taylor MR, Mestroni L (October 2014).
1982:
4385:
1682:
1652:
1618:
1602:
1231:
6707:
2858:"Recurrent and founder mutations in the Netherlands : Plakophilin-2 p.Arg79X mutation causing arrhythmogenic right ventricular cardiomyopathy/dysplasia"
3202:
Antoniades L, Tsatsopoulou A, Anastasakis A, Syrris P, Asimaki A, Panagiotakos D, Zambartas C, Stefanadis C, McKenna WJ, Protonotarios N (September 2006).
2626:
Cerrone M, Noorman M, Lin X, Chkourko H, Liang FX, van der Nagel R, Hund T, Birchmeier W, Mohler P, van Veen TA, van Rijen HV, Delmar M (September 2012).
2678:
Hong M, Bao L, Kefaloyianni E, Agullo-Pascual E, Chkourko H, Foster M, Taskin E, Zhandre M, Reid DA, Rothenberg E, Delmar M, Coetzee WA (November 2012).
921:
902:
145:
2817:"PKP2 mutations in sudden death from arrhythmogenic right ventricular cardiomyopathy (ARVC) and sudden unexpected death with negative autopsy (SUDNA)"
1388:
in mice severely disrupts normal heart morphogenesis. Mutant mice are embryonic lethal and exhibit deficits in the formation of adhering junctions in
4148:"Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization"
3935:
Mertens C, Kuhn C, Moll R, Schwetlick I, Franke WW (1999). "Desmosomal plakophilin 2 as a differentiation marker in normal and malignant tissues".
2947:
Syrris P, Ward D, Asimaki A, Sen-Chowdhry S, Ebrahim HY, Evans A, Hitomi N, Norman M, Pantazis A, Shaw AL, Elliott PM, McKenna WJ (January 2006).
4235:"Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes"
3964:
Schmidt A, Langbein L, Prätzel S, Rode M, Rackwitz HR, Franke WW (1999). "Plakophilin 3--a novel cell-type-specific desmosomal plaque protein".
3585:"Desmosomal gene analysis in arrhythmogenic right ventricular dysplasia/cardiomyopathy: spectrum of mutations and clinical impact in practice"
6702:
1898:
5013:
4311:
Dalal D, James C, Devanagondi R, Tichnell C, Tucker A, Prakasa K, Spevak PJ, Bluemke DA, Abraham T, Russell SD, Calkins H, Judge DP (2006).
2152:"Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling"
1880:
3906:
Bonné S, van Hengel J, van Roy F (1998). "Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily".
309:
56:
4378:
1129:
1136:
286:
1664:
1968:
3814:"A novel kind of tumor type-characteristic junction: plakophilin-2 as a major protein of adherens junctions in cardiac myxomata"
2527:"Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes"
5532:
1867:
1846:
1586:
1582:
1578:
1562:
1471:
5801:
5644:
4371:
3499:"Comprehensive desmosome mutation analysis in north americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy"
208:
183:
2020:
1863:
4278:"Clinical features of arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in plakophilin-2"
6680:
6234:
1990:
3243:
van
Tintelen JP, Hauer RN (July 2009). "Cardiomyopathies: New test for arrhythmogenic right ventricular cardiomyopathy".
3073:"Plakophilin-2 mutations are the major determinant of familial arrhythmogenic right ventricular dysplasia/cardiomyopathy"
1842:
4313:"Penetrance of mutations in plakophilin-2 among families with arrhythmogenic right ventricular dysplasia/cardiomyopathy"
3161:
Kirchner F, Schuetz A, Boldt LH, Martens K, Dittmar G, Haverkamp W, Thierfelder L, Heinemann U, Gerull B (August 2012).
125:
2193:"Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2"
4941:
3855:"Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque"
1739:
4103:
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004).
1450:
There are data to support molecular crosstalk between plakophilin-2 and proteins involved in mechanical junctions in
3163:"Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations"
322:
221:
6412:
3716:"Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype"
3114:"Arrhythmogenic right ventricular cardiomyopathy plakophilin-2 mutations disrupt desmosome assembly and stability"
1561:
mutations may be unveiled with pharmacological challenge. Evidence has also shown that plakophilin-2 binds to the
2908:"Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy"
315:
214:
3765:"Desmosomes and the sodium channel complex: implications for arrhythmogenic cardiomyopathy and Brugada syndrome"
2291:
Jefferson JJ, Leung CL, Liem RK (July 2004). "Plakins: goliaths that link cell junctions and the cytoskeleton".
6645:
3812:
Rickelt S, Rizzo S, Doerflinger Y, Zentgraf H, Basso C, Gerosa G, Thiene G, Moll R, Franke WW (November 2010).
966:
133:
4354:
GeneReviews/NCBI/NIH/UW entry on
Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, Autosomal Dominant
3626:"Skin-heart connection: what can the epidermis tell us about the myocardium in arrhythmogenic cardiomyopathy?"
2949:"Clinical expression of plakophilin-2 mutations in familial arrhythmogenic right ventricular cardiomyopathy"
1918:"Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque"
1819:
1610:
1509:
propagation. It has also been demonstrated that plakophilin-2 associates with an important component of the
947:
2334:
Bass-Zubek AE, Hobbs RP, Amargo EV, Garcia NJ, Hsieh SN, Chen X, Wahl JK, Denning MF, Green KJ (May 2008).
2768:"Identification of a PKP2 gene deletion in a family with arrhythmogenic right ventricular cardiomyopathy"
5064:
4418:
3450:"Mechanisms of disease: molecular genetics of arrhythmogenic right ventricular dysplasia/cardiomyopathy"
1339:
197:
2525:
Sato PY, Musa H, Coombs W, Guerrero-Serna G, Patiño GA, Taffet SM, Isom LL, Delmar M (September 2009).
2432:
Godsel LM, Dubash AD, Bass-Zubek AE, Amargo EV, Klessner JL, Hobbs RP, Chen X, Green KJ (August 2010).
4062:"Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate"
3667:"Titin and desmosomal genes in the natural history of arrhythmogenic right ventricular cardiomyopathy"
5333:
4159:
2680:"Heterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated disk"
2204:
1668:
1614:
1494:
1243:
22:
112:
6640:
5273:
2628:"Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency"
1408:
disarray and cardiac wall rupture. Further studies demonstrated that plakophilin-2 coordinate with
1087:
1040:
1261:). A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.
5093:
4723:
4185:
4019:
3430:
3268:
3143:
2981:
2383:
Grossmann KS, Grund C, Huelsken J, Behrend M, Erdmann B, Franke WW, Birchmeier W (October 2004).
2336:"Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly"
2316:
157:
2579:"Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc"
2191:
Mertens C, Hofmann I, Wang Z, Teichmann M, Sepehri Chong S, Schnölzer M, Franke WW (July 2001).
1112:
1091:
1061:
1036:
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Agullo-Pascual E, Reid DA, Keegan S, Sidhu M, Fenyö D, Rothenberg E, Delmar M (November 2013).
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1947:
1715:
1660:
1543:
1424:
1320:
1223:
105:
49:
6214:
4359:
OMIM entries on Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, Autosomal Dominant
1542:
amplitude, as well as a shift in gating and kinetics; pharmacological challenge also induced
6439:
6146:
6131:
6126:
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6116:
6106:
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5686:
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3377:
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2355:
2347:
2300:
2263:
2222:
2212:
2163:
2107:
2066:
2058:
1937:
1929:
1726:, suggesting that plakophilin-2 may serve as a valuable marker in the clinical diagnosis of
1708:
1554:
1546:
1506:
1444:
1311:
Plakophilin 2 functions to link cadherins to intermediate filaments in the cytoskeleton. In
1273:
1265:
567:
560:
402:
333:
277:
232:
6356:
6351:
6346:
6341:
6096:
6086:
6076:
6071:
6042:
5746:
5741:
4788:
4676:
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4641:
4621:
4525:
4505:
2577:
Sato PY, Coombs W, Lin X, Nekrasova O, Green KJ, Isom LL, Taffet SM, Delmar M (July 2011).
1400:
granular aggregates around embryonic day 10.5-11. Additional malformation included reduced
630:
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
6581:
5195:
5045:
4928:
4748:
377:
153:
4199:"Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer"
2483:"Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells"
4163:
2208:
6544:
6407:
5104:
4935:
4444:
4259:
4234:
3977:
3948:
3879:
3854:
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3715:
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3474:
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1215:
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4086:
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3731:
3382:
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3305:
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6696:
6603:
5568:
5438:
5387:
5337:
5277:
5199:
5167:
5108:
4894:
4413:
2385:"Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation"
2227:
2192:
1672:
1451:
1312:
596:
4023:
3642:
3625:
3514:
3434:
3272:
3179:
3162:
3147:
2434:"Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA"
2320:
137:
6452:
5507:
5262:
4806:
4398:
4189:
1535:
1459:
1420:
1405:
1365:
and plakophilin-2. Plakophilin is necessary for normal localization and content of
1211:
395:
174:
6424:
6402:
3682:
3364:
Sen-Chowdhry S, Syrris P, Ward D, Asimaki A, Sevdalis E, McKenna WJ (April 2007).
2985:
2815:
Zhang M, Tavora F, Oliveira JB, Li L, Franco M, Fowler D, Zhao Z, Burke A (2012).
2594:
2542:
2499:
2482:
1601:
have been associated with, have been shown to cause, and are considered common in
1589:
and mediates crosstalk between intercellular junctions and membrane excitability.
3418:
3048:
2268:
2251:
161:
6598:
6549:
6419:
6309:
5639:
5083:
5038:
4957:
4879:
4427:
3560:
3342:
3013:
2111:
1903:
National Center for Biotechnology Information, U.S. National Library of Medicine
1885:
National Center for Biotechnology Information, U.S. National Library of Medicine
1794:
1782:
1648:
1393:
1378:
1366:
1362:
1335:
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4329:
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4198:
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3813:
3220:
3203:
2743:
2197:
Proceedings of the National Academy of Sciences of the United States of America
478:
6650:
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5537:
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5240:
5235:
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5173:
5159:
5154:
5149:
5144:
5139:
5134:
5129:
5124:
5119:
4981:
4863:
4852:
4838:
4454:
4353:
4172:
4147:
3780:
3601:
3584:
3130:
3113:
2873:
2062:
1686:
1629:
1409:
1401:
1358:
1351:
1347:
1343:
1324:
1300:
1281:
1277:
1258:
1254:
294:
191:
141:
3256:
2948:
2833:
2816:
1636:
mutations result in instability of the plakophilin-2 protein due to enhanced
1628:. These mutations in general appear to disrupt the assembly and stability of
6479:
6474:
6469:
6429:
6267:
6262:
6257:
5615:
5595:
5250:
5245:
5225:
5220:
5215:
5205:
5114:
5018:
4952:
4044:
2696:
2481:
Oxford EM, Musa H, Maass K, Coombs W, Taffet SM, Delmar M (September 2007).
2449:
1694:
1675:
1550:
1440:
1436:
1428:
1397:
1374:
1370:
1328:
1316:
1219:
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866:
538:
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149:
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4015:
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3483:
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3391:
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3139:
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3056:
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2977:
2933:
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2842:
2801:
2751:
2715:
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2612:
2560:
2508:
2467:
2418:
2369:
2312:
2277:
2236:
2217:
2177:
2168:
2151:
2119:
2080:
1933:
762:
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
3927:
3465:
2400:
2351:
1951:
1553:
crosstalk with sodium channels in the heart, and suggest that the risk of
1176:
1171:
6593:
6554:
6486:
6459:
6326:
6314:
6189:
6184:
5625:
5620:
5542:
4976:
4971:
4833:
3870:
2783:
2643:
1354:
1160:
1011:
992:
1253:
have been identified. The first has a molecular weight of 97.4 kDa (881
747:
cell communication by electrical coupling involved in cardiac conduction
6620:
6574:
6464:
6394:
6363:
6293:
6288:
6252:
6247:
6242:
6209:
6179:
6174:
6169:
6164:
5849:
5781:
5776:
5771:
5766:
5761:
5653:
5590:
5078:
5023:
4964:
4947:
4908:
4394:
4250:
4120:
1637:
1581:
channel current density was ~40% smaller and regional heterogeneity of
1482:
1331:
1285:
1269:
1192:
978:
933:
4007:
1678:
has shown to be a highly sensitive and specific diagnostic indicator.
82:
78:
6539:
6521:
6516:
6511:
6506:
6496:
6331:
6224:
6219:
6204:
6199:
6111:
6057:
6022:
5997:
5992:
5987:
5982:
5972:
5967:
5957:
5942:
5937:
5819:
5814:
5809:
5721:
5711:
5691:
5676:
5671:
5666:
5661:
5527:
5298:
5293:
5050:
4716:
4711:
4701:
4479:
1800:
1752:
1727:
1723:
1719:
1656:
1566:
1144:
888:
2304:
2047:"Plakophilins: multifunctional scaffolds for adhesion and signaling"
2924:
2907:
1585:
channels was altered, suggesting that plakophilin-2 interacts with
6564:
6336:
6319:
6156:
6151:
6141:
6136:
6101:
6091:
6081:
6066:
6047:
6037:
6032:
6017:
6012:
6007:
6002:
5977:
5962:
5952:
5947:
5932:
5927:
5907:
5902:
5897:
5892:
5887:
5882:
5877:
5872:
5867:
5862:
5857:
5829:
5824:
5791:
5786:
5756:
5751:
5731:
5726:
5706:
5696:
5611:
5489:
5484:
5479:
5474:
5469:
5464:
5459:
5454:
5449:
5444:
5428:
5423:
5418:
5413:
5408:
5403:
5398:
5393:
5368:
5363:
5358:
5353:
5348:
5343:
5323:
5318:
5313:
5308:
5288:
5283:
4993:
4923:
4872:
4869:
4866:
4858:
4847:
4844:
4841:
4826:
4821:
4816:
4811:
4783:
4773:
4758:
4691:
4681:
4661:
4636:
4631:
4616:
4606:
4601:
4596:
4591:
4586:
4581:
4566:
4520:
4515:
4510:
4500:
4495:
4490:
4469:
4464:
4459:
4449:
4436:
1806:
1522:
1475:
1417:
851:
847:
6665:
6660:
6655:
6615:
6586:
6501:
6378:
6373:
6368:
6272:
5922:
5917:
5912:
5839:
5834:
5701:
5583:
5578:
5573:
5033:
5028:
4986:
4899:
4889:
4884:
4778:
4768:
4763:
4753:
4743:
4738:
4733:
4728:
4651:
4576:
4571:
4561:
4556:
4551:
4546:
4541:
4536:
1788:
1776:
1770:
1764:
1758:
1746:
1625:
1526:
1518:
1514:
1490:
1479:
1467:
1455:
1413:
1291:
Plakophilin 2 localizes to cell desmosomes and nuclei and binds
1250:
1199:
129:
4367:
2150:
Chen X, Bonne S, Hatzfeld M, van Roy F, Green KJ (March 2002).
576:
4197:
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005).
802:
regulation of ventricular cardiac muscle cell action potential
2045:
Bass-Zubek AE, Godsel LM, Delmar M, Green KJ (October 2009).
1272:
family. Plakophilin proteins contain nine central, conserved
4105:"Functional Proteomics Mapping of a Human Signaling Pathway"
1617:. It is estimated that 70% of all mutations associated with
757:
cardiac muscle cell action potential involved in contraction
1685:
is currently under intense investigation to understand the
1423:
rearrangement in order to properly couple the assembly of
1284:
domains. Alternately spliced transcripts encoding protein
4233:
Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006).
1722:
tumors analyzed, and absent in patients with noncardiac
1505:
alters sodium current properties as well as velocity of
385:
2017:
Cardiac Organellar Protein Atlas Knowledgebase (COPaKB)
2013:"Protein sequence of human PKP2 (Uniprot ID: Q99959-2)"
1987:
Cardiac Organellar Protein Atlas Knowledgebase (COPaKB)
1605:, which is characterized by fibrofatty replacement of
1338:, is the core constituent of the plaque which anchors
1257:) and the second of molecular weight of 92.7 kDa (837
1983:"Protein sequence of human PKP2 (Uniprot ID: Q99959)"
550:
21:"PKP2" redirects here. For the 2015 Indian film, see
4060:
Müller J, Ritt DA, Copeland TD, Morrison DK (2003).
6633:
6532:
6438:
6393:
6302:
6281:
6233:
6056:
5848:
5800:
5652:
5638:
5604:
5551:
5520:
5500:
5379:
5261:
5092:
5074:
5063:
5006:
4799:
4478:
4435:
4426:
4412:
4405:
1105:
1080:
1054:
1029:
2256:Biochimica et Biophysica Acta (BBA) - Biomembranes
1859:
1857:
1855:
1838:
1836:
1834:
767:cell-cell signaling involved in cardiac conduction
2092:
2090:
2040:
2038:
1549:. These findings further support the notion that
1373:, which may in part be due to the recruitment of
332:
231:
3454:Nature Clinical Practice Cardiovascular Medicine
1485:, as well as a decrease in coupling of adjacent
1431:precursors in newly formed cell-cell junctions.
752:ventricular cardiac muscle cell action potential
3112:Hall C, Li S, Li H, Creason V, Wahl JK (2009).
2252:"Desmosome structure, composition and function"
1683:arrhythmogenic right ventricular cardiomyopathy
1653:arrhythmogenic right ventricular cardiomyopathy
1619:arrhythmogenic right ventricular cardiomyopathy
1603:arrhythmogenic right ventricular cardiomyopathy
1232:arrhythmogenic right ventricular cardiomyopathy
772:ventricular cardiac muscle tissue morphogenesis
16:Protein-coding gene in the species Homo sapiens
1864:GRCm38: Ensembl release 89: ENSMUSG00000041957
1697:proteins, in disease progression and outcome.
1632:. Mechanistic studies have shown that certain
1525:downregulation mislocalized plakophilin-2 and
797:regulation of heart rate by cardiac conduction
4379:
1916:Mertens C, Kuhn C, Franke WW (January 1997).
1493:and plakophilin-2 are components in the same
1478:leads to a decrease in and redistribution of
8:
2673:
2671:
2572:
2570:
2520:
2518:
2145:
2143:
2141:
2139:
2137:
2135:
2133:
2131:
2129:
1474:. Decreased expression of plakophilin-2 via
1843:GRCh38: Ensembl release 89: ENSG00000057294
1693:mutations, as well as other genes encoding
1663:wall motion abnormalities, and ventricular
792:positive regulation of sodium ion transport
5649:
5089:
5071:
4432:
4423:
4409:
4386:
4372:
4364:
1703:mutations were also found to coexist with
862:
592:
373:
272:
169:
67:
4328:
4293:
4258:
4214:
4171:
4128:
4085:
3878:
3829:
3788:
3739:
3690:
3641:
3600:
3522:
3473:
3448:Awad MM, Calkins H, Judge DP (May 2008).
3381:
3304:
3219:
3178:
3129:
3088:
2967:
2923:
2881:
2832:
2791:
2705:
2695:
2651:
2602:
2550:
2498:
2457:
2408:
2359:
2267:
2226:
2216:
2167:
2070:
1941:
1714:Additionally, plakophilin-2 was found in
1681:Clinical and genetic characterization of
1202:. Plakophilin 2 is expressed in skin and
1963:
1961:
2098:ventricular dysplasia/cardiomyopathy".
1830:
822:protein localization to plasma membrane
509:cardiac muscle tissue of left ventricle
1538:null mutation, which showed decreased
27:
2293:Nature Reviews Molecular Cell Biology
1497:. Plakophilin-2 also associates with
742:intermediate filament bundle assembly
447:cardiac muscle tissue of right atrium
337:
298:
293:
236:
195:
190:
7:
6708:Armadillo-repeat-containing proteins
3630:Circulation: Cardiovascular Genetics
3503:Circulation: Cardiovascular Genetics
3167:Circulation: Cardiovascular Genetics
2732:European Journal of Medical Genetics
1501:, and knockdown of plakophilin-2 in
807:maintenance of animal organ identity
3037:International Journal of Cardiology
2684:The Journal of Biological Chemistry
2156:The Journal of Biological Chemistry
1462:; the voltage-gated sodium channel
1299:, and the desmosomal cadherins via
721:messenger ribonucleoprotein complex
3978:10.1046/j.1432-0436.1999.6450291.x
3949:10.1046/j.1432-0436.1999.6450277.x
2772:European Journal of Human Genetics
2250:Garrod D, Chidgey M (March 2008).
1643:Specific and sensitive markers of
1102:
1077:
1051:
1026:
1002:
983:
957:
938:
912:
893:
555:
473:
411:
390:
14:
4295:10.1161/CIRCULATIONAHA.105.568642
3769:Trends in Cardiovascular Medicine
3763:Cerrone M, Delmar M (July 2014).
3732:10.1161/CIRCULATIONAHA.113.003077
3383:10.1161/CIRCULATIONAHA.106.660241
3306:10.1161/CIRCULATIONAHA.110.988287
3118:Cell Communication & Adhesion
3090:10.1161/CIRCULATIONAHA.105.609719
2969:10.1161/CIRCULATIONAHA.105.561654
1969:"Entrez Gene: PKP2 plakophilin 2"
1458:, the major component of cardiac
1412:is required to properly localize
1264:Plakophilin-2 is a member of the
1210:to intermediate filaments in the
1195:that in humans is encoded by the
620:transmembrane transporter binding
610:sodium channel regulator activity
5014:Wiskott–Aldrich syndrome protein
1671:analysis of proteins comprising
1655:have been identified to include
1392:, including the dissociation of
1230:have been shown to be causal in
566:
559:
321:
314:
308:
285:
220:
213:
207:
182:
6235:Microtubule organising proteins
3643:10.1161/CIRCGENETICS.114.000647
3515:10.1161/CIRCGENETICS.109.858217
3180:10.1161/CIRCGENETICS.111.961854
2051:Current Opinion in Cell Biology
666:integral component of membrane
577:More reference expression data
539:More reference expression data
1:
6282:Microtubule severing proteins
3683:10.1136/jmedgenet-2014-102591
3407:Current Opinion in Cardiology
2595:10.1161/CIRCRESAHA.111.247023
2543:10.1161/CIRCRESAHA.109.201418
2500:10.1161/CIRCRESAHA.107.154252
2438:Molecular Biology of the Cell
1466:and its interacting subunit,
1206:, where it functions to link
837:adherens junction maintenance
615:intermediate filament binding
306:
205:
6703:Genes on human chromosome 12
4942:actin depolymerizing factors
3419:10.1097/HCO.0b013e3280d942c4
3049:10.1016/j.ijcard.2007.03.137
2269:10.1016/j.bbamem.2007.07.014
1315:, plakophilin-2 is found at
1218:, plakophilin-2 is found in
435:myocardium of left ventricle
6420:Plakoglobin (gamma catenin)
3671:Journal of Medical Genetics
3561:10.1016/j.hrthm.2009.09.070
3547:cardiomyopathy/dysplasia".
3343:10.1016/j.hrthm.2011.03.015
3014:10.1016/j.hrthm.2006.04.028
2389:The Journal of Cell Biology
2340:The Journal of Cell Biology
2112:10.1016/j.hrthm.2014.07.041
1489:. Studies also showed that
832:cell-cell junction assembly
6724:
4330:10.1016/j.jacc.2006.06.045
4216:10.1074/mcp.M500021-MCP200
3831:10.1038/modpathol.2010.138
3583:B, Charron P (June 2010).
3245:Nature Reviews. Cardiology
2744:10.1016/j.ejmg.2015.02.009
1222:structures located within
635:molecular adaptor activity
493:superior surface of tongue
463:mucosa of transverse colon
20:
6676:
4173:10.1016/j.cub.2004.07.051
3781:10.1016/j.tcm.2014.02.001
3131:10.1080/15419060903009329
2874:10.1007/s12471-010-0839-5
2862:Netherlands Heart Journal
2063:10.1016/j.ceb.2009.07.002
1899:"Mouse PubMed Reference:"
1881:"Human PubMed Reference:"
1175:
1170:
1166:
1159:
1143:
1124:
1109:
1084:
1073:
1058:
1033:
1022:
1009:
1005:
990:
986:
977:
964:
960:
945:
941:
932:
919:
915:
900:
896:
887:
872:
865:
861:
845:
595:
591:
574:
558:
549:
536:
485:
476:
423:
414:
384:
376:
372:
355:
342:
305:
284:
275:
271:
254:
241:
204:
181:
172:
168:
123:
120:
110:
103:
98:
75:
70:
53:
48:
43:
39:
35:
30:
6646:Prokaryotic cytoskeleton
3257:10.1038/nrcardio.2009.97
3221:10.1093/eurheartj/ehl184
2834:10.1253/circj.cj-11-0747
1427:to the translocation of
1327:membranes together. The
1137:Chr 16: 16.03 – 16.09 Mb
645:protein kinase C binding
4045:10.1242/jcs.113.13.2471
3859:Cardiovascular Research
3602:10.1093/europace/euq104
2697:10.1074/jbc.M112.412122
2632:Cardiovascular Research
2450:10.1091/mbc.E10-02-0131
1820:Skin fragility syndrome
1738:PKP2 has been shown to
1640:-mediated degradation.
1611:ventricular tachycardia
1573:from haploinsufficient
1130:Chr 12: 32.79 – 32.9 Mb
505:myocardium of ventricle
455:mucosa of sigmoid colon
3920:10.1006/geno.1998.5398
3624:Gerull B (June 2014).
3208:European Heart Journal
2218:10.1073/pnas.141219498
2169:10.1074/jbc.M108765200
1934:10.1083/jcb.135.4.1009
1705:sodium channelopathies
1375:protein kinase C alpha
1340:intermediate filaments
1323:, which link adjacent
1288:have been identified.
501:atrioventricular valve
116:, ARVD9, plakophilin 2
5266:(hard alpha-keratins)
5097:(soft alpha-keratins)
4203:Mol. Cell. Proteomics
3996:Cytogenet. Cell Genet
3466:10.1038/ncpcardio1182
2401:10.1083/jcb.200402096
2352:10.1083/jcb.200712133
1651:mutation carriers in
1593:Clinical significance
706:intermediate filament
640:alpha-catenin binding
300:Chromosome 16 (mouse)
198:Chromosome 12 (human)
6681:cytoskeletal defects
6641:Major sperm proteins
4317:J. Am. Coll. Cardiol
4078:10.1093/emboj/cdg426
2784:10.1038/ejhg.2013.39
2583:Circulation Research
2531:Circulation Research
2487:Circulation Research
1615:sudden cardiac death
1495:biomolecular complex
71:List of PDB id codes
44:Available structures
23:Pyaar Ka Punchnama 2
5094:Epithelial keratins
4164:2004CBio...14.1436J
2821:Circulation Journal
2209:2001PNAS...98.7795M
1669:immunohistochemical
1276:domains flanked by
513:endocardial cushion
4251:10.1101/gr.4039406
4121:10.1101/gr.2334104
3871:10.1093/cvr/cvt191
2644:10.1093/cvr/cvs218
1716:adherens junctions
1659:inversions, right
1437:desmosomal plaques
1425:adherens junctions
1350:and indirectly to
1321:intercalated discs
1319:structures within
1224:intercalated discs
967:ENSMUSG00000041957
827:cell-cell adhesion
782:desmosome assembly
735:Biological process
716:cornified envelope
676:cell-cell junction
659:Cellular component
603:Molecular function
525:epithelium of lens
439:right uterine tube
6688:
6687:
6629:
6628:
6389:
6388:
5634:
5633:
5516:
5515:
5059:
5058:
5002:
5001:
4008:10.1159/000015540
1707:in patients with
1565:channel subunit,
1557:in patients with
1396:and formation of
1361:, facilitated by
1186:
1185:
1182:
1181:
1155:
1154:
1120:
1119:
1099:
1098:
1069:
1068:
1048:
1047:
1018:
1017:
999:
998:
973:
972:
954:
953:
928:
927:
909:
908:
857:
856:
777:heart development
681:adherens junction
671:intercalated disc
587:
586:
583:
582:
545:
544:
532:
531:
470:
469:
368:
367:
267:
266:
94:
93:
90:
89:
54:Ortholog search:
6715:
5650:
5090:
5072:
4433:
4424:
4410:
4388:
4381:
4374:
4365:
4342:
4332:
4307:
4297:
4272:
4262:
4228:
4218:
4193:
4175:
4142:
4132:
4099:
4089:
4056:
4027:
3989:
3960:
3931:
3893:
3892:
3882:
3850:
3844:
3843:
3833:
3818:Modern Pathology
3809:
3803:
3802:
3792:
3760:
3754:
3753:
3743:
3726:(10): 1092–103.
3711:
3705:
3704:
3694:
3662:
3656:
3655:
3645:
3621:
3615:
3614:
3604:
3579:
3573:
3572:
3543:
3537:
3536:
3526:
3494:
3488:
3487:
3477:
3445:
3439:
3438:
3402:
3396:
3395:
3385:
3361:
3355:
3354:
3325:
3319:
3318:
3308:
3299:(23): 2690–700.
3283:
3277:
3276:
3240:
3234:
3233:
3223:
3199:
3193:
3192:
3182:
3158:
3152:
3151:
3133:
3109:
3103:
3102:
3092:
3067:
3061:
3060:
3032:
3026:
3025:
2996:
2990:
2989:
2971:
2953:
2944:
2938:
2937:
2927:
2902:
2896:
2895:
2885:
2853:
2847:
2846:
2836:
2812:
2806:
2805:
2795:
2762:
2756:
2755:
2726:
2720:
2719:
2709:
2699:
2690:(49): 41258–67.
2675:
2666:
2665:
2655:
2623:
2617:
2616:
2606:
2574:
2565:
2564:
2554:
2522:
2513:
2512:
2502:
2478:
2472:
2471:
2461:
2429:
2423:
2422:
2412:
2380:
2374:
2373:
2363:
2331:
2325:
2324:
2288:
2282:
2281:
2271:
2247:
2241:
2240:
2230:
2220:
2203:(14): 7795–800.
2188:
2182:
2181:
2171:
2162:(12): 10512–22.
2147:
2124:
2123:
2094:
2085:
2084:
2074:
2042:
2033:
2032:
2030:
2028:
2019:. Archived from
2009:
2003:
2002:
2000:
1998:
1989:. Archived from
1979:
1973:
1972:
1965:
1956:
1955:
1945:
1913:
1907:
1906:
1895:
1889:
1888:
1877:
1871:
1861:
1850:
1840:
1728:cardiac myxomata
1720:cardiac myxomata
1709:Brugada syndrome
1689:associated with
1667:. Additionally,
1507:action potential
1274:armadillo repeat
1268:and plakophilin
1266:armadillo repeat
1168:
1167:
1139:
1132:
1115:
1103:
1094:
1078:
1074:RefSeq (protein)
1064:
1052:
1043:
1027:
1003:
984:
958:
939:
913:
894:
863:
650:cadherin binding
593:
579:
570:
563:
556:
541:
489:Ileal epithelium
481:
479:Top expressed in
474:
419:
417:Top expressed in
412:
391:
374:
364:
351:
340:
325:
318:
312:
301:
289:
273:
263:
250:
239:
224:
217:
211:
200:
186:
170:
164:
162:PKP2 - orthologs
115:
108:
85:
68:
62:
41:
40:
28:
6723:
6722:
6718:
6717:
6716:
6714:
6713:
6712:
6693:
6692:
6689:
6684:
6672:
6625:
6528:
6434:
6385:
6298:
6277:
6229:
6052:
5844:
5796:
5642:
5630:
5600:
5547:
5512:
5496:
5380:Ungrouped alpha
5375:
5265:
5257:
5096:
5082:
5076:
5066:
5055:
4998:
4795:
4474:
4416:
4401:
4392:
4350:
4345:
4310:
4275:
4231:
4196:
4158:(16): 1436–50.
4145:
4102:
4072:(17): 4431–42.
4059:
4039:(13): 2471–83.
4030:
3992:
3966:Differentiation
3963:
3937:Differentiation
3934:
3905:
3901:
3899:Further reading
3896:
3852:
3851:
3847:
3824:(11): 1429–37.
3811:
3810:
3806:
3762:
3761:
3757:
3713:
3712:
3708:
3664:
3663:
3659:
3623:
3622:
3618:
3581:
3580:
3576:
3545:
3544:
3540:
3496:
3495:
3491:
3447:
3446:
3442:
3404:
3403:
3399:
3376:(13): 1710–20.
3363:
3362:
3358:
3327:
3326:
3322:
3285:
3284:
3280:
3242:
3241:
3237:
3214:(18): 2208–16.
3201:
3200:
3196:
3160:
3159:
3155:
3111:
3110:
3106:
3069:
3068:
3064:
3034:
3033:
3029:
2998:
2997:
2993:
2951:
2946:
2945:
2941:
2912:Nature Genetics
2904:
2903:
2899:
2855:
2854:
2850:
2814:
2813:
2809:
2778:(11): 1226–31.
2764:
2763:
2759:
2728:
2727:
2723:
2677:
2676:
2669:
2625:
2624:
2620:
2576:
2575:
2568:
2524:
2523:
2516:
2480:
2479:
2475:
2444:(16): 2844–59.
2431:
2430:
2426:
2382:
2381:
2377:
2333:
2332:
2328:
2305:10.1038/nrm1425
2290:
2289:
2285:
2249:
2248:
2244:
2190:
2189:
2185:
2149:
2148:
2127:
2096:
2095:
2088:
2044:
2043:
2036:
2026:
2024:
2023:on 12 July 2015
2011:
2010:
2006:
1996:
1994:
1993:on 12 July 2015
1981:
1980:
1976:
1967:
1966:
1959:
1915:
1914:
1910:
1897:
1896:
1892:
1879:
1878:
1874:
1862:
1853:
1841:
1832:
1828:
1816:
1736:
1621:are within the
1595:
1309:
1244:splice variants
1240:
1226:. Mutations in
1177:View/Edit Mouse
1172:View/Edit Human
1135:
1128:
1125:Location (UCSC)
1111:
1090:
1086:
1060:
1039:
1035:
948:ENSG00000057294
841:
730:
686:plasma membrane
654:
625:protein binding
575:
565:
564:
537:
528:
523:
519:
515:
511:
507:
503:
499:
495:
491:
477:
466:
461:
457:
453:
451:mucosa of colon
449:
445:
441:
437:
433:
429:
427:right ventricle
415:
359:
346:
338:
328:
327:
326:
319:
299:
276:Gene location (
258:
245:
237:
227:
226:
225:
218:
196:
173:Gene location (
124:
111:
104:
77:
55:
26:
17:
12:
11:
5:
6721:
6719:
6711:
6710:
6705:
6695:
6694:
6686:
6685:
6677:
6674:
6673:
6671:
6670:
6669:
6668:
6663:
6658:
6653:
6643:
6637:
6635:
6631:
6630:
6627:
6626:
6624:
6623:
6618:
6613:
6612:
6611:
6606:
6596:
6591:
6590:
6589:
6579:
6578:
6577:
6572:
6567:
6562:
6557:
6552:
6547:
6545:Corneodesmosin
6536:
6534:
6530:
6529:
6527:
6526:
6525:
6524:
6519:
6514:
6509:
6504:
6499:
6494:
6484:
6483:
6482:
6477:
6472:
6462:
6457:
6456:
6455:
6444:
6442:
6436:
6435:
6433:
6432:
6427:
6422:
6417:
6416:
6415:
6405:
6399:
6397:
6391:
6390:
6387:
6386:
6384:
6383:
6382:
6381:
6376:
6371:
6361:
6360:
6359:
6354:
6349:
6344:
6339:
6329:
6324:
6323:
6322:
6312:
6306:
6304:
6300:
6299:
6297:
6296:
6291:
6285:
6283:
6279:
6278:
6276:
6275:
6270:
6265:
6260:
6255:
6250:
6245:
6239:
6237:
6231:
6230:
6228:
6227:
6222:
6217:
6212:
6207:
6202:
6197:
6192:
6187:
6182:
6177:
6172:
6167:
6160:
6159:
6154:
6149:
6144:
6139:
6134:
6129:
6124:
6119:
6114:
6109:
6104:
6099:
6094:
6089:
6084:
6079:
6074:
6069:
6062:
6060:
6054:
6053:
6051:
6050:
6045:
6040:
6035:
6030:
6025:
6020:
6015:
6010:
6005:
6000:
5995:
5990:
5985:
5980:
5975:
5970:
5965:
5960:
5955:
5950:
5945:
5940:
5935:
5930:
5925:
5920:
5915:
5910:
5905:
5900:
5895:
5890:
5885:
5880:
5875:
5870:
5865:
5860:
5854:
5852:
5846:
5845:
5843:
5842:
5837:
5832:
5827:
5822:
5817:
5812:
5806:
5804:
5798:
5797:
5795:
5794:
5789:
5784:
5779:
5774:
5769:
5764:
5759:
5754:
5749:
5744:
5739:
5734:
5729:
5724:
5719:
5714:
5709:
5704:
5699:
5694:
5689:
5684:
5679:
5674:
5669:
5664:
5658:
5656:
5647:
5636:
5635:
5632:
5631:
5629:
5628:
5623:
5618:
5612:Nuclear lamins
5608:
5606:
5602:
5601:
5599:
5598:
5593:
5588:
5587:
5586:
5581:
5576:
5566:
5561:
5555:
5553:
5549:
5548:
5546:
5545:
5540:
5535:
5530:
5524:
5522:
5518:
5517:
5514:
5513:
5511:
5510:
5504:
5502:
5498:
5497:
5495:
5494:
5493:
5492:
5487:
5482:
5477:
5472:
5467:
5462:
5457:
5452:
5447:
5434:
5433:
5432:
5431:
5426:
5421:
5416:
5411:
5406:
5401:
5396:
5383:
5381:
5377:
5376:
5374:
5373:
5372:
5371:
5366:
5361:
5356:
5351:
5346:
5329:
5328:
5327:
5326:
5321:
5316:
5311:
5306:
5301:
5296:
5291:
5286:
5269:
5267:
5259:
5258:
5256:
5255:
5254:
5253:
5248:
5243:
5238:
5233:
5228:
5223:
5218:
5213:
5208:
5191:
5190:
5189:
5188:
5178:
5177:
5176:
5164:
5163:
5162:
5157:
5152:
5147:
5142:
5137:
5132:
5127:
5122:
5117:
5100:
5098:
5087:
5069:
5061:
5060:
5057:
5056:
5054:
5053:
5048:
5043:
5042:
5041:
5036:
5031:
5021:
5016:
5010:
5008:
5004:
5003:
5000:
4999:
4997:
4996:
4991:
4990:
4989:
4984:
4974:
4969:
4968:
4967:
4962:
4961:
4960:
4955:
4938:
4936:Arp2/3 complex
4933:
4932:
4931:
4926:
4921:
4916:
4905:
4904:
4903:
4902:
4897:
4892:
4887:
4877:
4876:
4875:
4861:
4850:
4831:
4830:
4829:
4824:
4819:
4814:
4803:
4801:
4797:
4796:
4794:
4793:
4792:
4791:
4786:
4781:
4776:
4771:
4766:
4761:
4756:
4751:
4746:
4741:
4736:
4731:
4721:
4720:
4719:
4714:
4706:
4705:
4704:
4696:
4695:
4694:
4686:
4685:
4684:
4679:
4671:
4670:
4669:
4664:
4656:
4655:
4654:
4646:
4645:
4644:
4639:
4634:
4626:
4625:
4624:
4619:
4611:
4610:
4609:
4604:
4599:
4594:
4589:
4584:
4579:
4574:
4569:
4564:
4559:
4554:
4549:
4544:
4539:
4531:
4530:
4529:
4523:
4518:
4513:
4508:
4503:
4498:
4493:
4484:
4482:
4476:
4475:
4473:
4472:
4467:
4462:
4457:
4452:
4447:
4441:
4439:
4430:
4421:
4414:Microfilaments
4407:
4403:
4402:
4393:
4391:
4390:
4383:
4376:
4368:
4362:
4361:
4356:
4349:
4348:External links
4346:
4344:
4343:
4323:(7): 1416–24.
4308:
4288:(13): 1641–9.
4273:
4229:
4194:
4143:
4115:(7): 1324–32.
4100:
4057:
4028:
4002:(3–4): 286–7.
3990:
3972:(5): 291–306.
3961:
3932:
3902:
3900:
3897:
3895:
3894:
3845:
3804:
3755:
3706:
3677:(10): 669–76.
3657:
3616:
3574:
3538:
3489:
3440:
3397:
3356:
3337:(8): 1214–21.
3320:
3278:
3235:
3194:
3153:
3124:(1–3): 15–27.
3104:
3083:(13): 1650–8.
3062:
3027:
2991:
2939:
2925:10.1038/ng1461
2918:(11): 1162–4.
2897:
2868:(12): 583–91.
2848:
2807:
2757:
2721:
2667:
2618:
2589:(2): 193–201.
2566:
2514:
2473:
2424:
2375:
2326:
2283:
2242:
2183:
2125:
2106:(11): 2010–7.
2086:
2034:
2004:
1974:
1957:
1928:(4): 1009–25.
1908:
1890:
1872:
1851:
1829:
1827:
1824:
1823:
1822:
1815:
1812:
1811:
1810:
1804:
1798:
1792:
1786:
1780:
1774:
1768:
1762:
1756:
1750:
1735:
1732:
1607:cardiomyocytes
1594:
1591:
1571:cardiomyocytes
1569:, and that in
1517:, and loss of
1503:cardiomyocytes
1487:cardiomyocytes
1452:cardiomyocytes
1390:cardiomyocytes
1313:cardiomyocytes
1308:
1305:
1239:
1236:
1216:cardiac muscle
1204:cardiac muscle
1184:
1183:
1180:
1179:
1174:
1164:
1163:
1157:
1156:
1153:
1152:
1150:
1148:
1141:
1140:
1133:
1126:
1122:
1121:
1118:
1117:
1107:
1106:
1100:
1097:
1096:
1082:
1081:
1075:
1071:
1070:
1067:
1066:
1056:
1055:
1049:
1046:
1045:
1031:
1030:
1024:
1020:
1019:
1016:
1015:
1007:
1006:
1000:
997:
996:
988:
987:
981:
975:
974:
971:
970:
962:
961:
955:
952:
951:
943:
942:
936:
930:
929:
926:
925:
917:
916:
910:
907:
906:
898:
897:
891:
885:
884:
879:
874:
870:
869:
859:
858:
855:
854:
843:
842:
840:
839:
834:
829:
824:
819:
814:
812:keratinization
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
738:
736:
732:
731:
729:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
662:
660:
656:
655:
653:
652:
647:
642:
637:
632:
627:
622:
617:
612:
606:
604:
600:
599:
589:
588:
585:
584:
581:
580:
572:
571:
553:
547:
546:
543:
542:
534:
533:
530:
529:
527:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
483:
482:
471:
468:
467:
465:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
421:
420:
408:
407:
399:
388:
382:
381:
378:RNA expression
370:
369:
366:
365:
357:
353:
352:
344:
341:
336:
330:
329:
320:
313:
307:
303:
302:
297:
291:
290:
282:
281:
269:
268:
265:
264:
256:
252:
251:
243:
240:
235:
229:
228:
219:
212:
206:
202:
201:
194:
188:
187:
179:
178:
166:
165:
122:
118:
117:
109:
101:
100:
96:
95:
92:
91:
88:
87:
73:
72:
64:
63:
52:
46:
45:
37:
36:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
6720:
6709:
6706:
6704:
6701:
6700:
6698:
6691:
6683:
6682:
6675:
6667:
6664:
6662:
6659:
6657:
6654:
6652:
6649:
6648:
6647:
6644:
6642:
6639:
6638:
6636:
6632:
6622:
6619:
6617:
6614:
6610:
6607:
6605:
6602:
6601:
6600:
6597:
6595:
6592:
6588:
6585:
6584:
6583:
6580:
6576:
6573:
6571:
6568:
6566:
6563:
6561:
6558:
6556:
6553:
6551:
6548:
6546:
6543:
6542:
6541:
6538:
6537:
6535:
6531:
6523:
6520:
6518:
6515:
6513:
6510:
6508:
6505:
6503:
6500:
6498:
6495:
6493:
6490:
6489:
6488:
6485:
6481:
6478:
6476:
6473:
6471:
6468:
6467:
6466:
6463:
6461:
6458:
6454:
6451:
6450:
6449:
6446:
6445:
6443:
6441:
6437:
6431:
6428:
6426:
6425:Delta catenin
6423:
6421:
6418:
6414:
6411:
6410:
6409:
6406:
6404:
6403:Alpha catenin
6401:
6400:
6398:
6396:
6392:
6380:
6377:
6375:
6372:
6370:
6367:
6366:
6365:
6362:
6358:
6355:
6353:
6350:
6348:
6345:
6343:
6340:
6338:
6335:
6334:
6333:
6330:
6328:
6325:
6321:
6318:
6317:
6316:
6313:
6311:
6308:
6307:
6305:
6301:
6295:
6292:
6290:
6287:
6286:
6284:
6280:
6274:
6271:
6269:
6266:
6264:
6261:
6259:
6256:
6254:
6251:
6249:
6246:
6244:
6241:
6240:
6238:
6236:
6232:
6226:
6223:
6221:
6218:
6216:
6213:
6211:
6208:
6206:
6203:
6201:
6198:
6196:
6193:
6191:
6188:
6186:
6183:
6181:
6178:
6176:
6173:
6171:
6168:
6166:
6163:cytoplasmic:
6162:
6161:
6158:
6155:
6153:
6150:
6148:
6145:
6143:
6140:
6138:
6135:
6133:
6130:
6128:
6125:
6123:
6120:
6118:
6115:
6113:
6110:
6108:
6105:
6103:
6100:
6098:
6095:
6093:
6090:
6088:
6085:
6083:
6080:
6078:
6075:
6073:
6070:
6068:
6064:
6063:
6061:
6059:
6055:
6049:
6046:
6044:
6041:
6039:
6036:
6034:
6031:
6029:
6026:
6024:
6021:
6019:
6016:
6014:
6011:
6009:
6006:
6004:
6001:
5999:
5996:
5994:
5991:
5989:
5986:
5984:
5981:
5979:
5976:
5974:
5971:
5969:
5966:
5964:
5961:
5959:
5956:
5954:
5951:
5949:
5946:
5944:
5941:
5939:
5936:
5934:
5931:
5929:
5926:
5924:
5921:
5919:
5916:
5914:
5911:
5909:
5906:
5904:
5901:
5899:
5896:
5894:
5891:
5889:
5886:
5884:
5881:
5879:
5876:
5874:
5871:
5869:
5866:
5864:
5861:
5859:
5856:
5855:
5853:
5851:
5847:
5841:
5838:
5836:
5833:
5831:
5828:
5826:
5823:
5821:
5818:
5816:
5813:
5811:
5808:
5807:
5805:
5803:
5799:
5793:
5790:
5788:
5785:
5783:
5780:
5778:
5775:
5773:
5770:
5768:
5765:
5763:
5760:
5758:
5755:
5753:
5750:
5748:
5745:
5743:
5740:
5738:
5735:
5733:
5730:
5728:
5725:
5723:
5720:
5718:
5715:
5713:
5710:
5708:
5705:
5703:
5700:
5698:
5695:
5693:
5690:
5688:
5685:
5683:
5680:
5678:
5675:
5673:
5670:
5668:
5665:
5663:
5660:
5659:
5657:
5655:
5651:
5648:
5646:
5641:
5637:
5627:
5624:
5622:
5619:
5617:
5613:
5610:
5609:
5607:
5603:
5597:
5594:
5592:
5589:
5585:
5582:
5580:
5577:
5575:
5572:
5571:
5570:
5569:Neurofilament
5567:
5565:
5562:
5560:
5557:
5556:
5554:
5550:
5544:
5541:
5539:
5536:
5534:
5531:
5529:
5526:
5525:
5523:
5519:
5509:
5506:
5505:
5503:
5499:
5491:
5488:
5486:
5483:
5481:
5478:
5476:
5473:
5471:
5468:
5466:
5463:
5461:
5458:
5456:
5453:
5451:
5448:
5446:
5443:
5442:
5441:
5440:
5439:chromosome 12
5436:
5435:
5430:
5427:
5425:
5422:
5420:
5417:
5415:
5412:
5410:
5407:
5405:
5402:
5400:
5397:
5395:
5392:
5391:
5390:
5389:
5388:chromosome 17
5385:
5384:
5382:
5378:
5370:
5367:
5365:
5362:
5360:
5357:
5355:
5352:
5350:
5347:
5345:
5342:
5341:
5340:
5339:
5338:chromosome 12
5335:
5331:
5330:
5325:
5322:
5320:
5317:
5315:
5312:
5310:
5307:
5305:
5302:
5300:
5297:
5295:
5292:
5290:
5287:
5285:
5282:
5281:
5280:
5279:
5278:chromosome 17
5275:
5271:
5270:
5268:
5264:
5263:Hair keratins
5260:
5252:
5249:
5247:
5244:
5242:
5239:
5237:
5234:
5232:
5229:
5227:
5224:
5222:
5219:
5217:
5214:
5212:
5209:
5207:
5204:
5203:
5202:
5201:
5200:chromosome 12
5197:
5193:
5192:
5187:
5184:
5183:
5182:
5179:
5175:
5172:
5171:
5170:
5169:
5168:chromosome 12
5165:
5161:
5158:
5156:
5153:
5151:
5148:
5146:
5143:
5141:
5138:
5136:
5133:
5131:
5128:
5126:
5123:
5121:
5118:
5116:
5113:
5112:
5111:
5110:
5109:chromosome 17
5106:
5102:
5101:
5099:
5095:
5091:
5088:
5085:
5080:
5073:
5070:
5068:
5065:Intermediate
5062:
5052:
5049:
5047:
5044:
5040:
5037:
5035:
5032:
5030:
5027:
5026:
5025:
5022:
5020:
5017:
5015:
5012:
5011:
5009:
5005:
4995:
4992:
4988:
4985:
4983:
4980:
4979:
4978:
4975:
4973:
4970:
4966:
4963:
4959:
4956:
4954:
4951:
4950:
4949:
4946:
4945:
4944:
4943:
4939:
4937:
4934:
4930:
4927:
4925:
4922:
4920:
4917:
4915:
4912:
4911:
4910:
4907:
4906:
4901:
4898:
4896:
4893:
4891:
4888:
4886:
4883:
4882:
4881:
4878:
4874:
4871:
4868:
4865:
4862:
4860:
4857:
4854:
4851:
4849:
4846:
4843:
4840:
4837:
4836:
4835:
4832:
4828:
4825:
4823:
4820:
4818:
4815:
4813:
4810:
4809:
4808:
4805:
4804:
4802:
4798:
4790:
4787:
4785:
4782:
4780:
4777:
4775:
4772:
4770:
4767:
4765:
4762:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4742:
4740:
4737:
4735:
4732:
4730:
4727:
4726:
4725:
4722:
4718:
4715:
4713:
4710:
4709:
4707:
4703:
4700:
4699:
4697:
4693:
4690:
4689:
4687:
4683:
4680:
4678:
4675:
4674:
4672:
4668:
4665:
4663:
4660:
4659:
4657:
4653:
4650:
4649:
4647:
4643:
4640:
4638:
4635:
4633:
4630:
4629:
4627:
4623:
4620:
4618:
4615:
4614:
4612:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4590:
4588:
4585:
4583:
4580:
4578:
4575:
4573:
4570:
4568:
4565:
4563:
4560:
4558:
4555:
4553:
4550:
4548:
4545:
4543:
4540:
4538:
4535:
4534:
4532:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4492:
4489:
4488:
4486:
4485:
4483:
4481:
4477:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4442:
4440:
4438:
4434:
4431:
4429:
4425:
4422:
4420:
4415:
4411:
4408:
4404:
4400:
4396:
4389:
4384:
4382:
4377:
4375:
4370:
4369:
4366:
4360:
4357:
4355:
4352:
4351:
4347:
4340:
4336:
4331:
4326:
4322:
4318:
4314:
4309:
4305:
4301:
4296:
4291:
4287:
4283:
4279:
4274:
4270:
4266:
4261:
4256:
4252:
4248:
4244:
4240:
4236:
4230:
4226:
4222:
4217:
4212:
4209:(6): 785–95.
4208:
4204:
4200:
4195:
4191:
4187:
4183:
4179:
4174:
4169:
4165:
4161:
4157:
4153:
4149:
4144:
4140:
4136:
4131:
4126:
4122:
4118:
4114:
4110:
4106:
4101:
4097:
4093:
4088:
4083:
4079:
4075:
4071:
4067:
4063:
4058:
4054:
4050:
4046:
4042:
4038:
4034:
4029:
4025:
4021:
4017:
4013:
4009:
4005:
4001:
3997:
3991:
3987:
3983:
3979:
3975:
3971:
3967:
3962:
3958:
3954:
3950:
3946:
3943:(5): 277–90.
3942:
3938:
3933:
3929:
3925:
3921:
3917:
3913:
3909:
3904:
3903:
3898:
3890:
3886:
3881:
3876:
3872:
3868:
3865:(2): 231–40.
3864:
3860:
3856:
3849:
3846:
3841:
3837:
3832:
3827:
3823:
3819:
3815:
3808:
3805:
3800:
3796:
3791:
3786:
3782:
3778:
3775:(5): 184–90.
3774:
3770:
3766:
3759:
3756:
3751:
3747:
3742:
3737:
3733:
3729:
3725:
3721:
3717:
3710:
3707:
3702:
3698:
3693:
3688:
3684:
3680:
3676:
3672:
3668:
3661:
3658:
3653:
3649:
3644:
3639:
3635:
3631:
3627:
3620:
3617:
3612:
3608:
3603:
3598:
3594:
3590:
3586:
3578:
3575:
3570:
3566:
3562:
3558:
3554:
3550:
3542:
3539:
3534:
3530:
3525:
3520:
3516:
3512:
3509:(5): 428–35.
3508:
3504:
3500:
3493:
3490:
3485:
3481:
3476:
3471:
3467:
3463:
3460:(5): 258–67.
3459:
3455:
3451:
3444:
3441:
3436:
3432:
3428:
3424:
3420:
3416:
3413:(3): 185–92.
3412:
3408:
3401:
3398:
3393:
3389:
3384:
3379:
3375:
3371:
3367:
3360:
3357:
3352:
3348:
3344:
3340:
3336:
3332:
3324:
3321:
3316:
3312:
3307:
3302:
3298:
3294:
3290:
3282:
3279:
3274:
3270:
3266:
3262:
3258:
3254:
3250:
3246:
3239:
3236:
3231:
3227:
3222:
3217:
3213:
3209:
3205:
3198:
3195:
3190:
3186:
3181:
3176:
3173:(4): 400–11.
3172:
3168:
3164:
3157:
3154:
3149:
3145:
3141:
3137:
3132:
3127:
3123:
3119:
3115:
3108:
3105:
3100:
3096:
3091:
3086:
3082:
3078:
3074:
3066:
3063:
3058:
3054:
3050:
3046:
3043:(1): 92–100.
3042:
3038:
3031:
3028:
3023:
3019:
3015:
3011:
3008:(8): 939–44.
3007:
3003:
2995:
2992:
2987:
2983:
2979:
2975:
2970:
2965:
2962:(3): 356–64.
2961:
2957:
2950:
2943:
2940:
2935:
2931:
2926:
2921:
2917:
2913:
2909:
2901:
2898:
2893:
2889:
2884:
2879:
2875:
2871:
2867:
2863:
2859:
2852:
2849:
2844:
2840:
2835:
2830:
2827:(1): 189–94.
2826:
2822:
2818:
2811:
2808:
2803:
2799:
2794:
2789:
2785:
2781:
2777:
2773:
2769:
2761:
2758:
2753:
2749:
2745:
2741:
2738:(4): 258–65.
2737:
2733:
2725:
2722:
2717:
2713:
2708:
2703:
2698:
2693:
2689:
2685:
2681:
2674:
2672:
2668:
2663:
2659:
2654:
2649:
2645:
2641:
2637:
2633:
2629:
2622:
2619:
2614:
2610:
2605:
2600:
2596:
2592:
2588:
2584:
2580:
2573:
2571:
2567:
2562:
2558:
2553:
2548:
2544:
2540:
2536:
2532:
2528:
2521:
2519:
2515:
2510:
2506:
2501:
2496:
2493:(7): 703–11.
2492:
2488:
2484:
2477:
2474:
2469:
2465:
2460:
2455:
2451:
2447:
2443:
2439:
2435:
2428:
2425:
2420:
2416:
2411:
2406:
2402:
2398:
2395:(1): 149–60.
2394:
2390:
2386:
2379:
2376:
2371:
2367:
2362:
2357:
2353:
2349:
2346:(4): 605–13.
2345:
2341:
2337:
2330:
2327:
2322:
2318:
2314:
2310:
2306:
2302:
2299:(7): 542–53.
2298:
2294:
2287:
2284:
2279:
2275:
2270:
2265:
2262:(3): 572–87.
2261:
2257:
2253:
2246:
2243:
2238:
2234:
2229:
2224:
2219:
2214:
2210:
2206:
2202:
2198:
2194:
2187:
2184:
2179:
2175:
2170:
2165:
2161:
2157:
2153:
2146:
2144:
2142:
2140:
2138:
2136:
2134:
2132:
2130:
2126:
2121:
2117:
2113:
2109:
2105:
2101:
2093:
2091:
2087:
2082:
2078:
2073:
2068:
2064:
2060:
2057:(5): 708–16.
2056:
2052:
2048:
2041:
2039:
2035:
2022:
2018:
2014:
2008:
2005:
1992:
1988:
1984:
1978:
1975:
1970:
1964:
1962:
1958:
1953:
1949:
1944:
1939:
1935:
1931:
1927:
1923:
1919:
1912:
1909:
1904:
1900:
1894:
1891:
1886:
1882:
1876:
1873:
1869:
1865:
1860:
1858:
1856:
1852:
1848:
1844:
1839:
1837:
1835:
1831:
1825:
1821:
1818:
1817:
1813:
1808:
1805:
1802:
1799:
1796:
1793:
1790:
1787:
1784:
1781:
1778:
1775:
1772:
1769:
1766:
1765:desmocollin 2
1763:
1760:
1759:desmocollin 1
1757:
1754:
1751:
1748:
1745:
1744:
1743:
1741:
1733:
1731:
1729:
1725:
1721:
1717:
1712:
1710:
1706:
1702:
1698:
1696:
1692:
1688:
1684:
1679:
1677:
1674:
1673:cardiomyocyte
1670:
1666:
1665:extrasystoles
1662:
1658:
1654:
1650:
1646:
1641:
1639:
1635:
1631:
1627:
1624:
1620:
1616:
1612:
1608:
1604:
1600:
1597:Mutations in
1592:
1590:
1588:
1584:
1580:
1576:
1572:
1568:
1564:
1560:
1556:
1552:
1548:
1545:
1541:
1537:
1533:
1528:
1524:
1520:
1516:
1512:
1508:
1504:
1500:
1496:
1492:
1488:
1484:
1481:
1477:
1473:
1469:
1465:
1461:
1460:gap junctions
1457:
1453:
1448:
1446:
1442:
1438:
1432:
1430:
1426:
1422:
1419:
1415:
1411:
1407:
1403:
1402:trabeculation
1399:
1395:
1391:
1387:
1382:
1380:
1376:
1372:
1368:
1364:
1360:
1356:
1353:
1349:
1345:
1341:
1337:
1333:
1330:
1326:
1322:
1318:
1314:
1306:
1304:
1303:head domain.
1302:
1298:
1294:
1289:
1287:
1283:
1279:
1275:
1271:
1267:
1262:
1260:
1256:
1252:
1249:
1245:
1237:
1235:
1233:
1229:
1225:
1221:
1217:
1213:
1209:
1205:
1201:
1198:
1194:
1190:
1189:Plakophilin-2
1178:
1173:
1169:
1165:
1162:
1158:
1151:
1149:
1146:
1142:
1138:
1134:
1131:
1127:
1123:
1116:
1114:
1108:
1104:
1101:
1095:
1093:
1089:
1083:
1079:
1076:
1072:
1065:
1063:
1057:
1053:
1050:
1044:
1042:
1038:
1032:
1028:
1025:
1023:RefSeq (mRNA)
1021:
1014:
1013:
1008:
1004:
1001:
995:
994:
989:
985:
982:
980:
976:
969:
968:
963:
959:
956:
950:
949:
944:
940:
937:
935:
931:
924:
923:
918:
914:
911:
905:
904:
899:
895:
892:
890:
886:
883:
880:
878:
875:
871:
868:
864:
860:
853:
849:
844:
838:
835:
833:
830:
828:
825:
823:
820:
818:
817:cornification
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
787:cell adhesion
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
739:
737:
734:
733:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
701:cell junction
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
663:
661:
658:
657:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
607:
605:
602:
601:
598:
597:Gene ontology
594:
590:
578:
573:
569:
562:
557:
554:
552:
548:
540:
535:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
487:
484:
480:
475:
472:
462:
458:
454:
450:
446:
443:right auricle
442:
438:
434:
431:apex of heart
430:
426:
425:
422:
418:
413:
410:
409:
406:
404:
400:
398:
397:
393:
392:
389:
387:
383:
379:
375:
371:
363:
358:
354:
350:
345:
339:16|16 A2
335:
331:
324:
317:
311:
304:
296:
292:
288:
283:
279:
274:
270:
262:
257:
253:
249:
244:
234:
230:
223:
216:
210:
203:
199:
193:
189:
185:
180:
176:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
119:
114:
107:
102:
97:
86:
84:
80:
74:
69:
66:
65:
61:
58:
51:
47:
42:
38:
34:
29:
24:
19:
6690:
6678:
6608:
6453:Dystroglycan
6408:Beta catenin
5640:Microtubules
5508:Beta-keratin
5437:
5386:
5332:
5272:
5194:
5180:
5166:
5103:
4940:
4807:Tropomodulin
4399:cytoskeleton
4320:
4316:
4285:
4281:
4245:(1): 55–65.
4242:
4238:
4206:
4202:
4155:
4151:
4112:
4108:
4069:
4065:
4036:
4032:
3999:
3995:
3969:
3965:
3940:
3936:
3914:(3): 452–4.
3911:
3907:
3862:
3858:
3848:
3821:
3817:
3807:
3772:
3768:
3758:
3723:
3719:
3709:
3674:
3670:
3660:
3636:(3): 225–7.
3633:
3629:
3619:
3595:(6): 861–8.
3592:
3588:
3577:
3552:
3549:Heart Rhythm
3548:
3541:
3506:
3502:
3492:
3457:
3453:
3443:
3410:
3406:
3400:
3373:
3369:
3359:
3334:
3331:Heart Rhythm
3330:
3323:
3296:
3292:
3281:
3251:(7): 450–1.
3248:
3244:
3238:
3211:
3207:
3197:
3170:
3166:
3156:
3121:
3117:
3107:
3080:
3076:
3065:
3040:
3036:
3030:
3005:
3002:Heart Rhythm
3001:
2994:
2959:
2955:
2942:
2915:
2911:
2900:
2865:
2861:
2851:
2824:
2820:
2810:
2775:
2771:
2760:
2735:
2731:
2724:
2687:
2683:
2638:(4): 460–8.
2635:
2631:
2621:
2586:
2582:
2537:(6): 523–6.
2534:
2530:
2490:
2486:
2476:
2441:
2437:
2427:
2392:
2388:
2378:
2343:
2339:
2329:
2296:
2292:
2286:
2259:
2255:
2245:
2200:
2196:
2186:
2159:
2155:
2103:
2100:Heart Rhythm
2099:
2054:
2050:
2025:. Retrieved
2021:the original
2016:
2007:
1995:. Retrieved
1991:the original
1986:
1977:
1925:
1921:
1911:
1902:
1893:
1884:
1875:
1777:desmoglein 2
1771:desmoglein 1
1753:beta catenin
1737:
1734:Interactions
1713:
1700:
1699:
1690:
1680:
1644:
1642:
1633:
1622:
1598:
1596:
1574:
1558:
1536:heterozygous
1531:
1454:, including
1449:
1433:
1421:cytoskeletal
1406:cytoskeletal
1385:
1384:Ablation of
1383:
1310:
1290:
1263:
1247:
1241:
1227:
1212:cytoskeleton
1196:
1188:
1187:
1110:
1088:NP_001005242
1085:
1059:
1041:NM_001005242
1034:
1010:
991:
965:
946:
920:
901:
881:
876:
401:
394:
121:External IDs
76:
18:
6599:Plakophilin
6550:Desmoplakin
6310:Tau protein
5084:Cytokeratin
4880:Tropomyosin
4428:Myofilament
4282:Circulation
4033:J. Cell Sci
3720:Circulation
3555:(1): 22–9.
3370:Circulation
3293:Circulation
3077:Circulation
2956:Circulation
1922:J Cell Biol
1795:plakoglobin
1789:connexin 43
1783:desmoplakin
1661:ventricular
1649:plakoglobin
1555:arrhythmias
1547:arrhythmias
1544:ventricular
1527:connexin 43
1480:connexin 43
1456:connexin 43
1398:cytoplasmic
1394:desmoplakin
1379:desmoplakin
1367:desmoplakin
1363:plakoglobin
1352:sarcolemmal
1336:desmoplakin
1325:sarcolemmal
1297:desmoplakin
1293:plakoglobin
1259:amino acids
1255:amino acids
696:nucleoplasm
521:Paneth cell
497:gallbladder
360:16,090,576
347:16,031,182
259:32,896,777
246:32,790,755
99:Identifiers
6697:Categories
6679:See also:
6651:Crescentin
6570:Periplakin
6560:Envoplakin
6448:Dystrophin
6065:axonemal:
5559:Internexin
5538:Peripherin
4239:Genome Res
4152:Curr. Biol
4109:Genome Res
1870:, May 2017
1849:, May 2017
1826:References
1695:desmosomal
1687:penetrance
1676:desmosomes
1630:desmosomes
1551:desmosomes
1470:; and the
1410:E-cadherin
1371:desmosomes
1359:N-terminus
1348:C-terminus
1344:sarcolemma
1329:desmosomal
1301:N-terminal
1282:C-terminal
1278:N-terminal
405:(ortholog)
142:HomoloGene
6268:Centrin 3
6263:Centrin 2
6258:Centrin 1
5596:Syncoilin
5501:Not alpha
5067:filaments
5019:Fibrillin
1747:ankyrin G
1519:ankyrin G
1515:ankyrin G
1513:complex,
1468:ankyrin G
1441:cytoplasm
1429:desmosome
1416:early in
1355:cadherins
1317:desmosome
1238:Structure
1220:desmosome
1208:cadherins
1113:NP_080439
1092:NP_004563
1062:NM_026163
1037:NM_004572
867:Orthologs
726:cytoplasm
691:desmosome
150:GeneCards
6634:Nonhuman
6594:Vinculin
6555:Dystonin
6487:Spectrin
6460:Utrophin
6440:Membrane
6395:Catenins
6327:Stathmin
6315:Dynactin
6195:DYNC2LI1
6190:DYNC1LI2
6185:DYNC1LI1
5850:Kinesins
5654:Tubulins
5543:Vimentin
5075:Type 1/2
4977:Profilin
4972:Gelsolin
4834:Troponin
4395:Proteins
4339:17010805
4304:16549640
4269:16344560
4225:15778465
4182:15324660
4139:15231748
4096:12941695
4053:10852826
4024:35411706
4016:10828611
3986:10374265
3957:10374264
3908:Genomics
3889:23929525
3840:20693980
3799:24656989
3750:24352520
3701:25157032
3652:24951656
3611:20400443
3589:Europace
3569:20129281
3533:20031617
3484:18382419
3435:24552922
3427:17413274
3392:17372169
3351:21397041
3315:21606396
3273:20454940
3265:19554004
3230:16893920
3189:22781308
3148:19077857
3140:19533476
3099:16567567
3057:17521752
3022:16876743
2978:16415378
2934:15489853
2892:21301620
2843:22019812
2802:23486541
2752:25765472
2716:23066018
2662:22764151
2613:21617128
2561:19661460
2509:17673670
2468:20554761
2419:15479741
2370:18474624
2321:32003509
2313:15232572
2278:17854763
2237:11416169
2178:11790773
2120:25087486
2081:19674883
1866:–
1845:–
1814:See also
1740:interact
1724:myxomata
1540:Na(V)1.5
1511:Na(V)1.5
1499:Na(V)1.5
1464:Na(V)1.5
1307:Function
1286:isoforms
1161:Wikidata
846:Sources:
238:12p11.21
6621:PLEKHA7
6575:Plectin
6540:Plakins
6465:Ankyrin
6364:Dynamin
6294:Spastin
6289:Katanin
6253:CAMSAP3
6248:CAMSAP2
6243:CAMSAP1
6215:DYNLRB2
6210:DYNLRB1
6180:DYNC1I2
6175:DYNC1I1
6170:DYNC2H1
6165:DYNC1H1
6058:Dyneins
5782:TUBGCP6
5777:TUBGCP5
5772:TUBGCP4
5767:TUBGCP3
5762:TUBGCP2
5591:Synemin
5334:type II
5196:type II
5079:Keratin
5024:Filamin
4965:Destrin
4948:Cofilin
4909:Actinin
4480:Myosins
4397:of the
4260:1356129
4190:2371325
4160:Bibcode
3928:9721216
3880:3797628
3790:4099253
3741:3954430
3692:4465780
3524:2801867
3475:2822988
2883:3018603
2793:3798844
2707:3510824
2653:3422082
2604:3139453
2552:2742576
2459:2921118
2410:2172504
2361:2386101
2205:Bibcode
2072:3091506
2027:11 July
1997:11 July
1952:8922383
1943:2133394
1868:Ensembl
1847:Ensembl
1638:calpain
1483:protein
1439:in the
1357:by its
1346:by its
1342:to the
1332:protein
1270:protein
1246:of the
1193:protein
979:UniProt
934:Ensembl
873:Species
852:QuickGO
711:nucleus
380:pattern
138:1914701
106:Aliases
6522:SPTBN5
6517:SPTBN4
6512:SPTBN2
6507:SPTBN1
6497:SPTAN1
6332:Tektin
6225:DYNLT3
6220:DYNLT1
6205:DYNLL2
6200:DYNLL1
6147:DNALI1
6132:DNAH17
6127:DNAH14
6122:DNAH13
6117:DNAH12
6112:DNAH11
6107:DNAH10
6028:KIF26B
6023:KIF26A
5998:KIF21B
5993:KIF21A
5988:KIF20B
5983:KIF20A
5973:KIF18B
5968:KIF18A
5958:KIF16B
5943:KIF13B
5938:KIF13A
5737:TUBB4Q
5722:TUBB2C
5717:TUBB2B
5712:TUBB2A
5692:TUBA4A
5687:TUBA3E
5682:TUBA3D
5677:TUBA3C
5672:TUBA1C
5667:TUBA1B
5662:TUBA1A
5605:Type 5
5564:Nestin
5552:Type 4
5528:Desmin
5521:Type 3
5274:type I
5105:type I
5051:TRIOBP
4717:MYO18B
4712:MYO18A
4708:XVIII
4702:MYO15A
4437:Actins
4337:
4302:
4267:
4257:
4223:
4188:
4180:
4137:
4130:442148
4127:
4094:
4087:202368
4084:
4066:EMBO J
4051:
4022:
4014:
3984:
3955:
3926:
3887:
3877:
3838:
3797:
3787:
3748:
3738:
3699:
3689:
3650:
3609:
3567:
3531:
3521:
3482:
3472:
3433:
3425:
3390:
3349:
3313:
3271:
3263:
3228:
3187:
3146:
3138:
3097:
3055:
3020:
2986:819048
2984:
2976:
2932:
2890:
2880:
2841:
2800:
2790:
2750:
2714:
2704:
2660:
2650:
2611:
2601:
2559:
2549:
2507:
2466:
2456:
2417:
2407:
2368:
2358:
2319:
2311:
2276:
2235:
2225:
2176:
2118:
2079:
2069:
1950:
1940:
1801:Kir6.2
1742:with:
1657:T-wave
1587:K(ATP)
1583:K(ATP)
1579:K(ATP)
1577:mice,
1567:Kir6.2
1563:K(ATP)
1472:K(ATP)
1445:RPC155
1147:search
1145:PubMed
1012:Q9CQ73
993:Q99959
889:Entrez
551:BioGPS
517:atrium
459:rectum
130:602861
6582:Talin
6565:MACF1
6533:Other
6492:SPTA1
6357:TEKT5
6352:TEKT4
6347:TEKT3
6342:TEKT2
6337:TEKT1
6320:DCTN1
6303:Other
6157:DNAL4
6152:DNAL1
6142:DNAI2
6137:DNAI1
6102:DNAH9
6097:DNAH8
6092:DNAH7
6087:DNAH6
6082:DNAH5
6077:DNAH3
6072:DNAH2
6067:DNAH1
6048:KIFC3
6043:KIFC2
6038:KIFC1
6033:KIF27
6018:KIF25
6013:KIF24
6008:KIF23
6003:KIF22
5978:KIF19
5963:KIF17
5953:KIF15
5948:KIF14
5933:KIF12
5928:KIF11
5908:KIF5C
5903:KIF5B
5898:KIF5A
5893:KIF4B
5888:KIF4A
5883:KIF3C
5878:KIF3B
5873:KIF2C
5868:KIF2A
5863:KIF1B
5858:KIF1A
5830:MAP1B
5825:MAP1A
5792:TUBE1
5787:TUBD1
5757:TUBG2
5752:TUBG1
5747:TUBB8
5742:TUBB6
5732:TUBB4
5727:TUBB3
5707:TUBB1
5697:TUBA8
5046:Espin
5007:Other
4994:Titin
4800:Other
4789:MYLL1
4784:MYLK2
4774:MYLIP
4759:MYL6B
4692:MYO10
4682:MYO9B
4677:MYO9A
4667:MYO7B
4662:MYO7A
4642:MYO5C
4637:MYO5B
4632:MYO5A
4622:MYO3B
4617:MYO3A
4607:MYH16
4602:MYH15
4597:MYH14
4592:MYH13
4587:MYH11
4582:MYH10
4567:MYH7B
4526:MYO1H
4521:MYO1G
4516:MYO1F
4511:MYO1E
4506:MYO1D
4501:MYO1C
4496:MYO1B
4491:MYO1A
4406:Human
4186:S2CID
4020:S2CID
3431:S2CID
3269:S2CID
3144:S2CID
2982:S2CID
2952:(PDF)
2317:S2CID
2228:35421
1807:SCN5A
1803:, and
1523:siRNA
1476:siRNA
1418:actin
1214:. In
1191:is a
922:67451
882:Mouse
877:Human
848:Amigo
403:Mouse
396:Human
343:Start
278:Mouse
242:Start
175:Human
6666:ParM
6661:MreB
6656:FtsZ
6616:ACF7
6609:PKP2
6604:PKP1
6587:TLN1
6502:SPTB
6480:ANK3
6475:ANK2
6470:ANK1
6379:DNM3
6374:DNM2
6369:DNM1
6273:PCM1
5923:KIF9
5918:KIF7
5913:KIF6
5840:MAP4
5835:MAP2
5802:MAPs
5702:TUBB
5645:MAPs
5643:and
5584:NEFH
5579:NEFM
5574:NEFL
5533:GFAP
5181:none
5039:FLNC
5034:FLNB
5029:FLNA
4779:MYLK
4769:MYL9
4764:MYL7
4754:MYL6
4749:MYL5
4744:MYL4
4739:MYL3
4734:MYL2
4729:MYL1
4658:VII
4652:MYO6
4613:III
4577:MYH9
4572:MYH8
4562:MYH7
4557:MYH6
4552:MYH4
4547:MYH3
4542:MYH2
4537:MYH1
4419:ABPs
4417:and
4335:PMID
4300:PMID
4265:PMID
4221:PMID
4178:PMID
4135:PMID
4092:PMID
4049:PMID
4012:PMID
3982:PMID
3953:PMID
3924:PMID
3885:PMID
3836:PMID
3795:PMID
3746:PMID
3697:PMID
3648:PMID
3607:PMID
3565:PMID
3529:PMID
3480:PMID
3423:PMID
3388:PMID
3347:PMID
3311:PMID
3261:PMID
3226:PMID
3185:PMID
3136:PMID
3095:PMID
3053:PMID
3018:PMID
2974:PMID
2930:PMID
2888:PMID
2839:PMID
2798:PMID
2748:PMID
2712:PMID
2658:PMID
2609:PMID
2557:PMID
2505:PMID
2464:PMID
2415:PMID
2366:PMID
2309:PMID
2274:PMID
2260:1778
2233:PMID
2174:PMID
2116:PMID
2077:PMID
2029:2015
1999:2015
1948:PMID
1701:PKP2
1691:PKP2
1647:and
1645:PKP2
1634:PKP2
1626:gene
1623:PKP2
1613:and
1599:PKP2
1575:PKP2
1559:PKP2
1532:PKP2
1521:via
1491:GJA1
1414:RhoA
1386:PKP2
1280:and
1251:gene
1248:PKP2
1242:Two
1228:PKP2
1200:gene
1197:PKP2
903:5318
386:Bgee
334:Band
295:Chr.
233:Band
192:Chr.
154:PKP2
146:3364
126:OMIM
113:PKP2
83:3TT9
81:,%%s
79:3TT9
60:RCSB
57:PDBe
31:PKP2
6430:GAN
6413:APC
5820:EB3
5815:EB2
5810:EB1
5616:A/C
5299:33B
5294:33A
4698:XV
4673:IX
4648:VI
4533:II
4325:doi
4290:doi
4286:113
4255:PMC
4247:doi
4211:doi
4168:doi
4125:PMC
4117:doi
4082:PMC
4074:doi
4041:doi
4037:113
4004:doi
3974:doi
3945:doi
3916:doi
3875:PMC
3867:doi
3863:100
3826:doi
3785:PMC
3777:doi
3736:PMC
3728:doi
3724:129
3687:PMC
3679:doi
3638:doi
3597:doi
3557:doi
3519:PMC
3511:doi
3470:PMC
3462:doi
3415:doi
3378:doi
3374:115
3339:doi
3301:doi
3297:123
3253:doi
3216:doi
3175:doi
3126:doi
3085:doi
3081:113
3045:doi
3041:126
3010:doi
2964:doi
2960:113
2920:doi
2878:PMC
2870:doi
2829:doi
2788:PMC
2780:doi
2740:doi
2702:PMC
2692:doi
2688:287
2648:PMC
2640:doi
2599:PMC
2591:doi
2587:109
2547:PMC
2539:doi
2535:105
2495:doi
2491:101
2454:PMC
2446:doi
2405:PMC
2397:doi
2393:167
2356:PMC
2348:doi
2344:181
2301:doi
2264:doi
2223:PMC
2213:doi
2164:doi
2160:277
2108:doi
2067:PMC
2059:doi
1938:PMC
1930:doi
1926:135
1718:of
1377:to
1369:to
356:End
255:End
158:OMA
134:MGI
50:PDB
6699::
5626:B2
5621:B1
5614::
5490:80
5485:79
5480:78
5475:77
5470:76
5465:75
5460:74
5455:73
5450:72
5445:71
5429:40
5424:39
5419:28
5414:27
5409:26
5404:25
5399:24
5394:23
5369:86
5364:85
5359:84
5354:83
5349:82
5344:81
5324:38
5319:37
5314:36
5309:35
5304:34
5289:32
5284:31
5241:6C
5236:6B
5231:6A
5211:2A
5186:21
5174:18
5160:20
5155:19
5150:17
5145:16
5140:15
5135:14
5130:13
5125:12
5120:10
4724:LC
4688:X
4628:V
4487:I
4470:G2
4465:G1
4460:C1
4450:A2
4445:A1
4333:.
4321:48
4319:.
4315:.
4298:.
4284:.
4280:.
4263:.
4253:.
4243:16
4241:.
4237:.
4219:.
4205:.
4201:.
4184:.
4176:.
4166:.
4156:14
4154:.
4150:.
4133:.
4123:.
4113:14
4111:.
4107:.
4090:.
4080:.
4070:22
4068:.
4064:.
4047:.
4035:.
4018:.
4010:.
4000:88
3998:.
3980:.
3970:64
3968:.
3951:.
3941:64
3939:.
3922:.
3912:51
3910:.
3883:.
3873:.
3861:.
3857:.
3834:.
3822:23
3820:.
3816:.
3793:.
3783:.
3773:24
3771:.
3767:.
3744:.
3734:.
3722:.
3718:.
3695:.
3685:.
3675:51
3673:.
3669:.
3646:.
3632:.
3628:.
3605:.
3593:12
3591:.
3587:.
3563:.
3551:.
3527:.
3517:.
3505:.
3501:.
3478:.
3468:.
3456:.
3452:.
3429:.
3421:.
3411:22
3409:.
3386:.
3372:.
3368:.
3345:.
3333:.
3309:.
3295:.
3291:.
3267:.
3259:.
3247:.
3224:.
3212:27
3210:.
3206:.
3183:.
3169:.
3165:.
3142:.
3134:.
3122:16
3120:.
3116:.
3093:.
3079:.
3075:.
3051:.
3039:.
3016:.
3004:.
2980:.
2972:.
2958:.
2954:.
2928:.
2916:36
2914:.
2910:.
2886:.
2876:.
2866:18
2864:.
2860:.
2837:.
2825:76
2823:.
2819:.
2796:.
2786:.
2776:21
2774:.
2770:.
2746:.
2736:58
2734:.
2710:.
2700:.
2686:.
2682:.
2670:^
2656:.
2646:.
2636:95
2634:.
2630:.
2607:.
2597:.
2585:.
2581:.
2569:^
2555:.
2545:.
2533:.
2529:.
2517:^
2503:.
2489:.
2485:.
2462:.
2452:.
2442:21
2440:.
2436:.
2413:.
2403:.
2391:.
2387:.
2364:.
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