1370:, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulfide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
3416:
3401:
520:
497:
394:
419:
771:
526:
425:
223:
3348:
1525:
McRae BJ, Kurachi K, Heimark RL, Fujikawa K, Davie EW, Powers JC (December 1981). "Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates".
249:
3415:
3400:
2026:
Henderson LM, Figueroa CD, Muller-Esterl W, Stain A, Bhoola KD (1992). "Immunovisualisation of Plasma
Prekallikrein and H-Kininogen on Human Neutrophils and in Human Hepatocytes". In Fritz H, MĂĽller-Esterl W, Jochum M, Roscher A, Luppertz K (eds.).
2414:
Durham SK, Suwanichkul A, Hayes JD, Herington AC, Powell DR, Campbell PG (1999). "The heparin binding domain of insulin-like growth factor binding protein (IGFBP)-3 increases susceptibility of IGFBP-3 to proteolysis".
2163:
Fujikawa K, Chung DW, Hendrickson LE, Davie EW (1986). "Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein".
1821:
Page JD, You JL, Harris RB, Colman RW (October 1994). "Localization of the binding site on plasma kallikrein for high-molecular-weight kininogen to both apple 1 and apple 4 domains of the heavy chain".
2356:
Petersen LC, Sprecher CA, Foster DC, Blumberg H, Hamamoto T, Kisiel W (1996). "Inhibitory properties of a novel human Kunitz-type protease inhibitor homologous to tissue factor pathway inhibitor".
2105:
McMullen BA, Fujikawa K, Davie EW (1991). "Location of the disulfide bonds in human plasma prekallikrein: the presence of four novel apple domains in the amino-terminal portion of the molecule".
2228:
Page JD, You JL, Harris RB, Colman RW (1994). "Localization of the binding site on plasma kallikrein for high-molecular-weight kininogen to both apple 1 and apple 4 domains of the heavy chain".
2487:
Hermann A, Arnhold M, Kresse H, Neth P, Fink E (1999). "Expression of plasma prekallikrein mRNA in human nonhepatic tissues and cell lineages suggests special local functions of the enzyme".
2385:
Hermann A, Buchinger P, Somlev B, Rehbock J (1996). "High and low molecular weight kininogen and plasma prekallikrein/plasma kallikrein in villous capillaries of human term placenta".
1678:
Yu H, Bowden DW, Spray BJ, Rich SS, Freedman BI (April 1998). "Identification of human plasma kallikrein gene polymorphisms and evaluation of their role in end-stage renal disease".
3424:: Expression, Crystallization and the Three-dimensional Structure of the Catalytic Domain of Human Plasma Kallikrein: Implications for Structure-Based Design of Protease Inhibitors
3002:
2195:"Mapping of the high molecular weight kininogen binding site of prekallikrein. Evidence for a discontinuous epitope formed by distinct segments of the prekallikrein heavy chain"
1859:"Mapping of the high molecular weight kininogen binding site of prekallikrein. Evidence for a discontinuous epitope formed by distinct segments of the prekallikrein heavy chain"
3409:: Expression, crystallization and three-dimensional structure of the catalytic domain of human plasma kallikrein: Implications for structure-based design of protease inhibitors
62:, callicrein, glumorin, padreatin, padutin, kallidinogenase, bradykininogenase, panceatic kallikrein, onokrein P, dilminal D, depot-Padutin, urokallikrein, urinary kallikrein
2862:
2068:
533:
432:
177:
2602:
196:
1713:
Chung DW, Fujikawa K, McMullen BA, Davie EW (August 1986). "Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats".
1602:
Seidah NG, Ladenheim R, Mbikay M, Hamelin J, Lutfalla G, Rougeon F, Lazure C, Chrétien M (October 1989). "The cDNA structure of rat plasma kallikrein".
1014:
355:
995:
2076:
Beaubien G, Rosinski-Chupin I, Mattei MG, Mbikay M, Chrétien M, Seidah NG (1991). "Gene structure and chromosomal localization of plasma kallikrein".
3380:
2044:
1578:
1501:
1466:
1448:
3444:
2327:
Ciechanowicz A, Bader M, Wagner J, Ganten D (1994). "Extra-hepatic transcription of plasma prekallikrein gene in human and rat tissues".
246:
2595:
1230:
519:
3067:
1237:
496:
189:
1748:
2454:"Mapping of the discontinuous H-kininogen binding site of plasma prekallikrein. Evidence for a critical role of apple domain-2"
1900:"Mapping of the discontinuous H-kininogen binding site of plasma prekallikrein. Evidence for a critical role of apple domain-2"
1435:
1414:
1383:
156:
2588:
132:
3223:
1431:
1639:"Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein"
418:
393:
1410:
2822:
335:
1379:
2580:
532:
431:
1637:
Tsuda Y, Teno N, Okada Y, Wanaka K, Bohgaki M, Hijikata-Okunomiya A, Okamoto U, Naito T, Okamoto S (November 1989).
3338:
3208:
525:
424:
3373:
3324:
3311:
3298:
3285:
3272:
3259:
3246:
2737:
2722:
2622:
150:
3218:
3172:
3115:
2619:
2574:
1997:
Aznar JA, España F, Aznar J, Tascon A, Jimenez C (1978). "Fletcher factor deficiency: report of a new family".
1293:
1059:
343:
31:
2134:
España F, Berrettini M, Griffin JH (1989). "Purification and characterization of plasma protein C inhibitor".
137:
2534:
Cerf M, Raidoo D, Fink E, Fritz H, Bhoola K (2000). "Plasma kallikrein localisation in human blood vessels".
3120:
3012:
2977:
2972:
1040:
2496:
1946:"Studies of binding of prekallikrein and Factor XI to high molecular weight kininogen and its light chain"
1764:"Studies of binding of prekallikrein and Factor XI to high molecular weight kininogen and its light chain"
201:
125:
3141:
3060:
2967:
2817:
3213:
48:
3366:
2957:
1957:
1775:
407:
2501:
322:
153:
3177:
2857:
2847:
2664:
2659:
1192:
1188:
1137:
1133:
77:
43:
3449:
3110:
2522:
2440:
2062:
367:
1213:
1184:
1158:
1129:
2839:
2551:
2514:
2475:
2432:
2402:
2373:
2344:
2315:
2280:
2245:
2216:
2181:
2151:
2122:
2093:
2050:
2040:
2014:
1985:
1921:
1880:
1839:
1803:
1730:
1695:
1660:
1619:
1584:
1574:
1543:
1507:
1497:
1308:
315:
239:
144:
2570:
3156:
3151:
3125:
3053:
2631:
2543:
2506:
2465:
2424:
2394:
2365:
2336:
2305:
2270:
2237:
2206:
2173:
2143:
2114:
2085:
2032:
2006:
1975:
1965:
1911:
1870:
1831:
1793:
1783:
1722:
1687:
1650:
1611:
1566:
1535:
1489:
612:
543:
487:
442:
113:
770:
363:
3203:
3187:
3100:
2872:
2867:
2639:
2615:
587:
89:
36:
1961:
1779:
3352:
3241:
3182:
2010:
222:
172:
2547:
2398:
2310:
2293:
2211:
2194:
1980:
1945:
1875:
1858:
1798:
1763:
1493:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
863:
858:
853:
848:
832:
827:
822:
817:
812:
3438:
3146:
3105:
3017:
2890:
2879:
2611:
2444:
2147:
1857:
Herwald H, Jahnen-Dechent W, Alla SA, Hock J, Bouma BN, MĂĽller-Esterl W (July 1993).
1570:
1347:
799:
2526:
3095:
2913:
2807:
2649:
2292:
Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N (1993).
2259:"Assembly of contact-phase factors on the surface of the human neutrophil membrane"
1484:
Heimark RL, Davie EW (1981). "[14] Bovine and human plasma prekallikrein".
1363:
605:
384:
347:
2036:
371:
3319:
3254:
3090:
3032:
3027:
2676:
2275:
2258:
2193:
Herwald H, Jahnen-Dechent W, Alla SA, Hock J, Bouma BN, MĂĽller-Esterl W (1993).
1471:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1453:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1367:
3347:
688:
2994:
2936:
2717:
2712:
2692:
1351:
1328:
504:
401:
351:
59:
2470:
2453:
2294:"Activation of the zymogen of hepatocyte growth factor activator by thrombin"
1916:
1899:
3293:
3267:
3022:
3008:
2827:
2707:
2697:
2031:. Agents and Actions Supplements. Vol. 38. Birkhäuser. pp. 590–4.
1970:
1788:
1691:
1324:
1304:
959:
748:
626:
571:
558:
470:
457:
359:
2555:
2518:
2479:
2436:
2340:
2241:
1925:
1835:
1615:
2428:
2406:
2377:
2348:
2319:
2284:
2249:
2220:
2185:
2155:
2126:
2097:
2054:
1884:
1843:
1734:
1699:
1664:
1623:
1588:
1547:
1511:
1277:
1272:
58:
serum kallikrein, kininogenin, kallikrein I, kallikrein II, kininogenase,
2908:
2903:
2852:
2702:
2687:
2654:
2018:
1989:
1898:
Renné T, Dedio J, Meijers JC, Chung D, Müller-Esterl W (September 1999).
1807:
1316:
1296:
1261:
1104:
1085:
101:
2510:
2177:
2118:
2089:
1726:
1655:
1638:
1539:
2962:
2952:
2898:
2812:
2644:
1071:
1026:
120:
2369:
292:
288:
284:
280:
276:
272:
268:
3306:
3076:
2989:
2931:
1320:
1300:
1245:
981:
184:
96:
84:
72:
3280:
2998:
2984:
2923:
2797:
2792:
2787:
2782:
2777:
2772:
944:
940:
2767:
2762:
2757:
2752:
2747:
2742:
2732:
2727:
1340:
339:
108:
3362:
3049:
2584:
2452:
Renné T, Dedio J, Meijers JC, Chung D, Müller-Esterl W (1999).
779:
3358:
2257:
Henderson LM, Figueroa CD, MĂĽller-Esterl W, Bhoola KD (1994).
1749:"Entrez Gene: KLKB1 kallikrein B, plasma (Fletcher factor) 1"
1561:
Silverberg M, Kaplan AP (1988). "[8] Prekallikrein".
1488:. Methods in Enzymology. Vol. 80 Pt C. pp. 157–72.
3045:
1565:. Methods in Enzymology. Vol. 163. pp. 85–95.
595:
1334:
Plasma kallikrein and its precursor are encoded by the
3336:
760:
3232:
3196:
3165:
3134:
3083:
2945:
2922:
2888:
2838:
2675:
2630:
1206:
1177:
1151:
1122:
195:
183:
171:
166:
143:
131:
119:
107:
95:
83:
71:
66:
54:
42:
30:
25:
20:
1427:
1425:
1423:
1406:
1404:
1402:
1323:- bonds, including Lys-Arg and Arg-Ser in (human)
1762:Thompson RE, Mandle R, Kaplan AP (October 1979).
1368:surface-dependent activation of blood coagulation
542:
441:
1378:Kallikrein and prekallikrein have been shown to
1432:GRCm38: Ensembl release 89: ENSMUSG00000109764
3374:
3061:
2596:
2067:: CS1 maint: DOI inactive as of April 2024 (
8:
1411:GRCh38: Ensembl release 89: ENSG00000164344
3381:
3367:
3359:
3068:
3054:
3046:
2603:
2589:
2581:
955:
795:
583:
482:
379:
257:
163:
2573:at the U.S. National Library of Medicine
2500:
2469:
2309:
2274:
2210:
1979:
1969:
1944:Thompson RE, Mandle R, Kaplan AP (1980).
1915:
1874:
1797:
1787:
1654:
3396:
3343:
1398:
2616:serine proteases/serine endopeptidases
2060:
1643:Chemical & Pharmaceutical Bulletin
212:
17:
1486:Bovine and human plasma prekallikrein
547:
508:
503:
446:
405:
400:
326:, KLK3, PPK, PKKD, PKK, kallikrein B1
7:
930:blood coagulation, intrinsic pathway
1999:Scandinavian Journal of Haematology
880:positive regulation of fibrinolysis
665:dorsal motor nucleus of vagus nerve
2011:10.1111/j.1600-0609.1978.tb02498.x
1203:
1174:
1148:
1119:
1095:
1076:
1050:
1031:
1005:
986:
818:serine-type endopeptidase activity
765:
683:
621:
600:
14:
3414:
3399:
3346:
910:extracellular matrix disassembly
769:
531:
524:
518:
495:
430:
423:
417:
392:
221:
1384:High-molecular-weight kininogen
813:serine-type peptidase activity
780:More reference expression data
749:More reference expression data
1:
2828:Urinary plasminogen activator
2548:10.1016/S0162-3109(99)00112-5
2399:10.1016/S0143-4004(96)90042-9
2329:Biochem. Biophys. Res. Commun
2311:10.1016/S0021-9258(18)41615-8
2212:10.1016/S0021-9258(19)85270-5
1876:10.1016/S0021-9258(19)85270-5
1494:10.1016/s0076-6879(81)80016-x
516:
415:
2823:Tissue plasminogen activator
2148:10.1016/0049-3848(89)90069-8
2037:10.1007/978-3-0348-7321-5_72
1950:Proc. Natl. Acad. Sci. U.S.A
1768:Proc. Natl. Acad. Sci. U.S.A
1571:10.1016/0076-6879(88)63010-2
673:Epithelium of choroid plexus
3445:Genes on human chromosome 4
2276:10.1182/blood.V84.2.474.474
1346:This enzyme is formed from
1315:Selective cleavage of some
3466:
1362:Plasma prekallikrein is a
711:sexually immature organism
657:pancreatic epithelial cell
3394:
3224:Michaelis–Menten kinetics
2914:Proteinase 3/Myeloblastin
2029:Recent Progress on Kinins
1467:"Mouse PubMed Reference:"
1449:"Human PubMed Reference:"
1366:that participates in the
1276:
1271:
1267:
1260:
1244:
1231:Chr 4: 186.21 – 186.26 Mb
1225:
1210:
1181:
1170:
1155:
1126:
1115:
1102:
1098:
1083:
1079:
1070:
1057:
1053:
1038:
1034:
1025:
1012:
1008:
993:
989:
980:
965:
958:
954:
938:
798:
794:
777:
768:
759:
746:
695:
686:
633:
624:
594:
586:
582:
565:
552:
515:
494:
485:
481:
464:
451:
414:
391:
382:
378:
333:
330:
320:
313:
308:
265:
260:
243:
238:
233:
229:
220:
215:
162:
3116:Diffusion-limited enzyme
2575:Medical Subject Headings
2471:10.1074/jbc.274.36.25777
1917:10.1074/jbc.274.36.25777
645:tendon of biceps brachii
2039:(inactive 2024-04-08).
1971:10.1073/pnas.76.10.4862
1789:10.1073/pnas.76.10.4862
1692:10.1161/01.hyp.31.4.906
1238:Chr 8: 45.72 – 45.75 Mb
2968:Proprotein convertases
2341:10.1006/bbrc.1993.2628
2242:10.1006/abbi.1994.1424
2230:Arch. Biochem. Biophys
1836:10.1006/abbi.1994.1424
1824:Arch. Biochem. Biophys
1616:10.1089/dna.1989.8.563
905:plasminogen activation
727:respiratory epithelium
715:neural layer of retina
549:8 B1.1|8 25.17 cM
3209:Eadie–Hofstee diagram
3142:Allosteric regulation
2818:Plasminogen activator
2429:10.1055/s-2007-978722
1350:(Fletcher factor) by
915:inflammatory response
890:Factor XII activation
849:extracellular exosome
669:middle temporal gyrus
3219:Lineweaver–Burk plot
2958:Prolyl endopeptidase
859:extracellular region
510:Chromosome 8 (mouse)
408:Chromosome 4 (human)
261:List of PDB id codes
234:Available structures
2511:10.1515/BC.1999.136
2178:10.1021/bi00357a018
2119:10.1021/bi00222a007
2090:10.1021/bi00220a027
1962:1979PNAS...76.4862T
1780:1979PNAS...76.4862T
1727:10.1021/bi00357a017
1656:10.1248/cpb.37.3108
1540:10.1021/bi00528a022
864:extracellular space
703:right lobe of liver
637:right lobe of liver
3178:Enzyme superfamily
3111:Enzyme promiscuity
2536:Immunopharmacology
1060:ENSMUSG00000109764
885:zymogen activation
873:Biological process
842:Cellular component
833:hydrolase activity
823:peptidase activity
806:Molecular function
719:epithelium of lens
699:left lobe of liver
3432:
3431:
3334:
3333:
3043:
3042:
2840:Complement system
2632:Digestive enzymes
2571:Plasma+kallikrein
2370:10.1021/bi951501d
2046:978-3-0348-7323-9
1580:978-0-12-182064-0
1503:978-0-12-181980-4
1309:chemical reaction
1290:Plasma kallikrein
1287:
1286:
1283:
1282:
1256:
1255:
1221:
1220:
1200:
1199:
1166:
1165:
1145:
1144:
1111:
1110:
1092:
1091:
1066:
1065:
1047:
1046:
1021:
1020:
1002:
1001:
950:
949:
925:blood coagulation
790:
789:
786:
785:
755:
754:
742:
741:
680:
679:
578:
577:
477:
476:
372:KLKB1 - orthologs
304:
303:
300:
299:
244:Ortholog search:
211:
210:
207:
206:
126:metabolic pathway
21:Plasma kallikrein
3457:
3418:
3403:
3383:
3376:
3369:
3360:
3351:
3350:
3342:
3214:Hanes–Woolf plot
3157:Enzyme activator
3152:Enzyme inhibitor
3126:Enzyme catalysis
3070:
3063:
3056:
3047:
2605:
2598:
2591:
2582:
2559:
2530:
2504:
2483:
2473:
2464:(36): 25777–84.
2448:
2417:Horm. Metab. Res
2410:
2381:
2352:
2323:
2313:
2304:(30): 22927–32.
2288:
2278:
2253:
2224:
2214:
2205:(19): 14527–35.
2189:
2159:
2130:
2101:
2072:
2066:
2058:
2022:
1993:
1983:
1973:
1930:
1929:
1919:
1910:(36): 25777–84.
1895:
1889:
1888:
1878:
1869:(19): 14527–35.
1854:
1848:
1847:
1818:
1812:
1811:
1801:
1791:
1759:
1753:
1752:
1745:
1739:
1738:
1710:
1704:
1703:
1675:
1669:
1668:
1658:
1634:
1628:
1627:
1599:
1593:
1592:
1558:
1552:
1551:
1534:(25): 7196–206.
1522:
1516:
1515:
1481:
1475:
1474:
1463:
1457:
1456:
1445:
1439:
1429:
1418:
1408:
1269:
1268:
1240:
1233:
1216:
1204:
1195:
1175:
1171:RefSeq (protein)
1161:
1149:
1140:
1120:
1096:
1077:
1051:
1032:
1006:
987:
956:
796:
782:
773:
766:
751:
735:nasal epithelium
691:
689:Top expressed in
684:
649:body of pancreas
629:
627:Top expressed in
622:
601:
584:
574:
561:
550:
535:
528:
522:
511:
499:
483:
473:
460:
449:
434:
427:
421:
410:
396:
380:
374:
325:
318:
295:
258:
252:
231:
230:
225:
213:
164:
18:
3465:
3464:
3460:
3459:
3458:
3456:
3455:
3454:
3435:
3434:
3433:
3428:
3425:
3419:
3410:
3404:
3390:
3387:
3357:
3345:
3337:
3335:
3330:
3242:Oxidoreductases
3228:
3204:Enzyme kinetics
3192:
3188:List of enzymes
3161:
3130:
3101:Catalytic triad
3079:
3074:
3044:
3039:
2941:
2918:
2884:
2834:
2671:
2640:Enteropeptidase
2626:
2609:
2567:
2562:
2533:
2502:10.1.1.657.2854
2495:(9): 1097–102.
2486:
2451:
2423:(2–3): 216–25.
2413:
2384:
2355:
2326:
2291:
2256:
2227:
2192:
2162:
2133:
2104:
2075:
2059:
2047:
2025:
1996:
1943:
1939:
1937:Further reading
1934:
1933:
1897:
1896:
1892:
1856:
1855:
1851:
1820:
1819:
1815:
1761:
1760:
1756:
1747:
1746:
1742:
1712:
1711:
1707:
1677:
1676:
1672:
1649:(11): 3108–11.
1636:
1635:
1631:
1601:
1600:
1596:
1581:
1560:
1559:
1555:
1524:
1523:
1519:
1504:
1483:
1482:
1478:
1465:
1464:
1460:
1447:
1446:
1442:
1430:
1421:
1409:
1400:
1395:
1389:
1376:
1360:
1278:View/Edit Mouse
1273:View/Edit Human
1236:
1229:
1226:Location (UCSC)
1212:
1191:
1187:
1183:
1157:
1136:
1132:
1128:
1041:ENSG00000164344
934:
868:
854:plasma membrane
837:
828:protein binding
778:
747:
738:
733:
729:
725:
721:
717:
713:
709:
705:
701:
687:
676:
671:
667:
663:
659:
655:
651:
647:
643:
639:
625:
569:
556:
548:
538:
537:
536:
529:
509:
486:Gene location (
468:
455:
447:
437:
436:
435:
428:
406:
383:Gene location (
334:
321:
314:
267:
245:
12:
11:
5:
3463:
3461:
3453:
3452:
3447:
3437:
3436:
3430:
3429:
3427:
3426:
3420:
3413:
3411:
3405:
3398:
3395:
3392:
3391:
3388:
3386:
3385:
3378:
3371:
3363:
3356:
3355:
3332:
3331:
3329:
3328:
3315:
3302:
3289:
3276:
3263:
3250:
3236:
3234:
3230:
3229:
3227:
3226:
3221:
3216:
3211:
3206:
3200:
3198:
3194:
3193:
3191:
3190:
3185:
3180:
3175:
3169:
3167:
3166:Classification
3163:
3162:
3160:
3159:
3154:
3149:
3144:
3138:
3136:
3132:
3131:
3129:
3128:
3123:
3118:
3113:
3108:
3103:
3098:
3093:
3087:
3085:
3081:
3080:
3075:
3073:
3072:
3065:
3058:
3050:
3041:
3040:
3038:
3037:
3036:
3035:
3030:
3020:
3015:
3006:
2992:
2987:
2982:
2981:
2980:
2975:
2965:
2960:
2955:
2949:
2947:
2943:
2942:
2940:
2939:
2934:
2928:
2926:
2920:
2919:
2917:
2916:
2911:
2906:
2901:
2895:
2893:
2886:
2885:
2883:
2882:
2877:
2876:
2875:
2870:
2860:
2855:
2850:
2844:
2842:
2836:
2835:
2833:
2832:
2831:
2830:
2825:
2815:
2803:
2802:
2801:
2800:
2795:
2790:
2785:
2780:
2775:
2770:
2765:
2760:
2755:
2750:
2745:
2740:
2735:
2730:
2725:
2715:
2710:
2705:
2700:
2695:
2690:
2681:
2679:
2673:
2672:
2670:
2669:
2668:
2667:
2662:
2652:
2647:
2642:
2636:
2634:
2628:
2627:
2612:Endopeptidases
2610:
2608:
2607:
2600:
2593:
2585:
2579:
2578:
2566:
2565:External links
2563:
2561:
2560:
2542:(1–2): 75–80.
2531:
2484:
2449:
2411:
2382:
2353:
2324:
2289:
2254:
2225:
2190:
2172:(9): 2417–24.
2160:
2131:
2102:
2084:(6): 1628–35.
2073:
2045:
2023:
1994:
1956:(10): 4862–6.
1940:
1938:
1935:
1932:
1931:
1890:
1849:
1813:
1774:(10): 4862–6.
1754:
1740:
1705:
1670:
1629:
1594:
1579:
1553:
1517:
1502:
1476:
1458:
1440:
1419:
1397:
1396:
1394:
1391:
1375:
1372:
1359:
1356:
1332:
1331:
1307:the following
1285:
1284:
1281:
1280:
1275:
1265:
1264:
1258:
1257:
1254:
1253:
1251:
1249:
1242:
1241:
1234:
1227:
1223:
1222:
1219:
1218:
1208:
1207:
1201:
1198:
1197:
1179:
1178:
1172:
1168:
1167:
1164:
1163:
1153:
1152:
1146:
1143:
1142:
1124:
1123:
1117:
1113:
1112:
1109:
1108:
1100:
1099:
1093:
1090:
1089:
1081:
1080:
1074:
1068:
1067:
1064:
1063:
1055:
1054:
1048:
1045:
1044:
1036:
1035:
1029:
1023:
1022:
1019:
1018:
1010:
1009:
1003:
1000:
999:
991:
990:
984:
978:
977:
972:
967:
963:
962:
952:
951:
948:
947:
936:
935:
933:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
876:
874:
870:
869:
867:
866:
861:
856:
851:
845:
843:
839:
838:
836:
835:
830:
825:
820:
815:
809:
807:
803:
802:
792:
791:
788:
787:
784:
783:
775:
774:
763:
757:
756:
753:
752:
744:
743:
740:
739:
737:
736:
732:
728:
724:
720:
716:
712:
708:
704:
700:
696:
693:
692:
681:
678:
677:
675:
674:
670:
666:
662:
661:jejunal mucosa
658:
654:
650:
646:
642:
638:
634:
631:
630:
618:
617:
609:
598:
592:
591:
588:RNA expression
580:
579:
576:
575:
567:
563:
562:
554:
551:
546:
540:
539:
530:
523:
517:
513:
512:
507:
501:
500:
492:
491:
479:
478:
475:
474:
466:
462:
461:
453:
450:
445:
439:
438:
429:
422:
416:
412:
411:
404:
398:
397:
389:
388:
376:
375:
332:
328:
327:
319:
311:
310:
306:
305:
302:
301:
298:
297:
263:
262:
254:
253:
242:
236:
235:
227:
226:
218:
217:
209:
208:
205:
204:
199:
193:
192:
187:
181:
180:
175:
169:
168:
160:
159:
148:
141:
140:
135:
129:
128:
123:
117:
116:
111:
105:
104:
99:
93:
92:
87:
81:
80:
75:
69:
68:
64:
63:
56:
52:
51:
46:
40:
39:
34:
28:
27:
23:
22:
13:
10:
9:
6:
4:
3:
2:
3462:
3451:
3448:
3446:
3443:
3442:
3440:
3423:
3417:
3412:
3408:
3402:
3397:
3393:
3384:
3379:
3377:
3372:
3370:
3365:
3364:
3361:
3354:
3349:
3344:
3340:
3326:
3322:
3321:
3316:
3313:
3309:
3308:
3303:
3300:
3296:
3295:
3290:
3287:
3283:
3282:
3277:
3274:
3270:
3269:
3264:
3261:
3257:
3256:
3251:
3248:
3244:
3243:
3238:
3237:
3235:
3231:
3225:
3222:
3220:
3217:
3215:
3212:
3210:
3207:
3205:
3202:
3201:
3199:
3195:
3189:
3186:
3184:
3183:Enzyme family
3181:
3179:
3176:
3174:
3171:
3170:
3168:
3164:
3158:
3155:
3153:
3150:
3148:
3147:Cooperativity
3145:
3143:
3140:
3139:
3137:
3133:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3109:
3107:
3106:Oxyanion hole
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3088:
3086:
3082:
3078:
3071:
3066:
3064:
3059:
3057:
3052:
3051:
3048:
3034:
3031:
3029:
3026:
3025:
3024:
3021:
3019:
3018:Streptokinase
3016:
3014:
3010:
3007:
3004:
3000:
2996:
2993:
2991:
2988:
2986:
2983:
2979:
2976:
2974:
2971:
2970:
2969:
2966:
2964:
2961:
2959:
2956:
2954:
2951:
2950:
2948:
2944:
2938:
2935:
2933:
2930:
2929:
2927:
2925:
2921:
2915:
2912:
2910:
2907:
2905:
2902:
2900:
2897:
2896:
2894:
2892:
2891:immune system
2887:
2881:
2880:C3-convertase
2878:
2874:
2871:
2869:
2866:
2865:
2864:
2861:
2859:
2856:
2854:
2851:
2849:
2846:
2845:
2843:
2841:
2837:
2829:
2826:
2824:
2821:
2820:
2819:
2816:
2814:
2811:
2809:
2805:
2804:
2799:
2796:
2794:
2791:
2789:
2786:
2784:
2781:
2779:
2776:
2774:
2771:
2769:
2766:
2764:
2761:
2759:
2756:
2754:
2751:
2749:
2746:
2744:
2741:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2720:
2719:
2716:
2714:
2711:
2709:
2706:
2704:
2701:
2699:
2696:
2694:
2691:
2689:
2686:
2683:
2682:
2680:
2678:
2674:
2666:
2663:
2661:
2658:
2657:
2656:
2653:
2651:
2648:
2646:
2643:
2641:
2638:
2637:
2635:
2633:
2629:
2624:
2621:
2617:
2613:
2606:
2601:
2599:
2594:
2592:
2587:
2586:
2583:
2576:
2572:
2569:
2568:
2564:
2557:
2553:
2549:
2545:
2541:
2537:
2532:
2528:
2524:
2520:
2516:
2512:
2508:
2503:
2498:
2494:
2490:
2485:
2481:
2477:
2472:
2467:
2463:
2459:
2458:J. Biol. Chem
2455:
2450:
2446:
2442:
2438:
2434:
2430:
2426:
2422:
2418:
2412:
2408:
2404:
2400:
2396:
2393:(4): 223–30.
2392:
2388:
2383:
2379:
2375:
2371:
2367:
2364:(1): 266–72.
2363:
2359:
2354:
2350:
2346:
2342:
2338:
2335:(3): 1370–6.
2334:
2330:
2325:
2321:
2317:
2312:
2307:
2303:
2299:
2298:J. Biol. Chem
2295:
2290:
2286:
2282:
2277:
2272:
2269:(2): 474–82.
2268:
2264:
2260:
2255:
2251:
2247:
2243:
2239:
2236:(1): 159–64.
2235:
2231:
2226:
2222:
2218:
2213:
2208:
2204:
2200:
2199:J. Biol. Chem
2196:
2191:
2187:
2183:
2179:
2175:
2171:
2167:
2161:
2157:
2153:
2149:
2145:
2142:(3): 369–84.
2141:
2137:
2132:
2128:
2124:
2120:
2116:
2113:(8): 2050–6.
2112:
2108:
2103:
2099:
2095:
2091:
2087:
2083:
2079:
2074:
2070:
2064:
2056:
2052:
2048:
2042:
2038:
2034:
2030:
2024:
2020:
2016:
2012:
2008:
2004:
2000:
1995:
1991:
1987:
1982:
1977:
1972:
1967:
1963:
1959:
1955:
1951:
1947:
1942:
1941:
1936:
1927:
1923:
1918:
1913:
1909:
1905:
1904:J. Biol. Chem
1901:
1894:
1891:
1886:
1882:
1877:
1872:
1868:
1864:
1863:J. Biol. Chem
1860:
1853:
1850:
1845:
1841:
1837:
1833:
1830:(1): 159–64.
1829:
1825:
1817:
1814:
1809:
1805:
1800:
1795:
1790:
1785:
1781:
1777:
1773:
1769:
1765:
1758:
1755:
1750:
1744:
1741:
1736:
1732:
1728:
1724:
1721:(9): 2410–7.
1720:
1716:
1709:
1706:
1701:
1697:
1693:
1689:
1686:(4): 906–11.
1685:
1681:
1674:
1671:
1666:
1662:
1657:
1652:
1648:
1644:
1640:
1633:
1630:
1625:
1621:
1617:
1613:
1610:(8): 563–74.
1609:
1605:
1598:
1595:
1590:
1586:
1582:
1576:
1572:
1568:
1564:
1563:Prekallikrein
1557:
1554:
1549:
1545:
1541:
1537:
1533:
1529:
1521:
1518:
1513:
1509:
1505:
1499:
1495:
1491:
1487:
1480:
1477:
1472:
1468:
1462:
1459:
1454:
1450:
1444:
1441:
1437:
1433:
1428:
1426:
1424:
1420:
1416:
1412:
1407:
1405:
1403:
1399:
1392:
1390:
1387:
1385:
1381:
1373:
1371:
1369:
1365:
1357:
1355:
1353:
1349:
1348:prekallikrein
1344:
1342:
1339:
1338:
1330:
1326:
1322:
1318:
1314:
1313:
1312:
1310:
1306:
1302:
1298:
1295:
1291:
1279:
1274:
1270:
1266:
1263:
1259:
1252:
1250:
1247:
1243:
1239:
1235:
1232:
1228:
1224:
1217:
1215:
1209:
1205:
1202:
1196:
1194:
1190:
1186:
1180:
1176:
1173:
1169:
1162:
1160:
1154:
1150:
1147:
1141:
1139:
1135:
1131:
1125:
1121:
1118:
1116:RefSeq (mRNA)
1114:
1107:
1106:
1101:
1097:
1094:
1088:
1087:
1082:
1078:
1075:
1073:
1069:
1062:
1061:
1056:
1052:
1049:
1043:
1042:
1037:
1033:
1030:
1028:
1024:
1017:
1016:
1011:
1007:
1004:
998:
997:
992:
988:
985:
983:
979:
976:
973:
971:
968:
964:
961:
957:
953:
946:
942:
937:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
877:
875:
872:
871:
865:
862:
860:
857:
855:
852:
850:
847:
846:
844:
841:
840:
834:
831:
829:
826:
824:
821:
819:
816:
814:
811:
810:
808:
805:
804:
801:
800:Gene ontology
797:
793:
781:
776:
772:
767:
764:
762:
758:
750:
745:
734:
730:
726:
722:
718:
714:
710:
706:
702:
698:
697:
694:
690:
685:
682:
672:
668:
664:
660:
656:
652:
648:
644:
640:
636:
635:
632:
628:
623:
620:
619:
616:
614:
610:
608:
607:
603:
602:
599:
597:
593:
589:
585:
581:
573:
568:
564:
560:
555:
545:
541:
534:
527:
521:
514:
506:
502:
498:
493:
489:
484:
480:
472:
467:
463:
459:
454:
444:
440:
433:
426:
420:
413:
409:
403:
399:
395:
390:
386:
381:
377:
373:
369:
365:
361:
357:
353:
349:
345:
341:
337:
329:
324:
317:
312:
307:
296:
294:
290:
286:
282:
278:
274:
270:
264:
259:
256:
255:
251:
248:
241:
237:
232:
228:
224:
219:
214:
203:
200:
198:
194:
191:
188:
186:
182:
179:
176:
174:
170:
165:
161:
158:
155:
152:
149:
146:
142:
139:
136:
134:
130:
127:
124:
122:
118:
115:
112:
110:
106:
103:
102:NiceZyme view
100:
98:
94:
91:
88:
86:
82:
79:
76:
74:
70:
65:
61:
57:
53:
50:
47:
45:
41:
38:
35:
33:
29:
24:
19:
16:
3421:
3406:
3320:Translocases
3317:
3304:
3291:
3278:
3265:
3255:Transferases
3252:
3239:
3096:Binding site
2808:fibrinolysis
2806:
2684:
2650:Chymotrypsin
2539:
2535:
2492:
2488:
2461:
2457:
2420:
2416:
2390:
2386:
2361:
2358:Biochemistry
2357:
2332:
2328:
2301:
2297:
2266:
2262:
2233:
2229:
2202:
2198:
2169:
2166:Biochemistry
2165:
2139:
2135:
2110:
2107:Biochemistry
2106:
2081:
2078:Biochemistry
2077:
2028:
2002:
1998:
1953:
1949:
1907:
1903:
1893:
1866:
1862:
1852:
1827:
1823:
1816:
1771:
1767:
1757:
1743:
1718:
1715:Biochemistry
1714:
1708:
1683:
1680:Hypertension
1679:
1673:
1646:
1642:
1632:
1607:
1603:
1597:
1562:
1556:
1531:
1528:Biochemistry
1527:
1520:
1485:
1479:
1470:
1461:
1452:
1443:
1388:
1377:
1374:Interactions
1364:glycoprotein
1361:
1345:
1336:
1335:
1333:
1289:
1288:
1211:
1193:NP_001305325
1189:NP_001305323
1182:
1156:
1138:NM_001318396
1134:NM_001318394
1127:
1103:
1084:
1058:
1039:
1013:
994:
974:
969:
900:fibrinolysis
723:right kidney
611:
604:
469:186,258,471
456:186,208,979
331:External IDs
266:
90:BRENDA entry
49:410538-33-9
15:
3389:PDB gallery
3091:Active site
2713:Factor XIIa
2693:Factor VIIa
2677:Coagulation
2136:Thromb. Res
2005:(2): 94–8.
1352:factor XIIa
1327:to release
895:proteolysis
570:45,747,896
557:45,719,726
309:Identifiers
78:IntEnz view
26:Identifiers
3439:Categories
3294:Isomerases
3268:Hydrolases
3135:Regulation
2995:Subtilisin
2937:Batroxobin
2718:Kallikrein
2708:Factor XIa
2698:Factor IXa
2665:Pancreatic
2660:Neutrophil
2489:Biol. Chem
1438:, May 2017
1417:, May 2017
1393:References
1329:bradykinin
920:hemostasis
615:(ortholog)
352:HomoloGene
147:structures
114:KEGG entry
60:kallikrein
55:Alt. names
3450:EC 3.4.21
3173:EC number
3023:Cathepsin
3009:Sedolisin
2985:Prostasin
2703:Factor Xa
2497:CiteSeerX
2445:260169268
2063:cite book
1325:kininogen
1305:catalyses
1297:3.4.21.34
1214:NP_032481
1185:NP_000883
1159:NM_008455
1130:NM_000892
960:Orthologs
707:spermatid
360:GeneCards
67:Databases
37:3.4.21.34
3197:Kinetics
3121:Cofactor
3084:Activity
2924:Venombin
2909:Tryptase
2904:Granzyme
2858:Factor I
2853:Factor D
2848:Factor B
2688:Thrombin
2685:factors:
2655:Elastase
2556:10604527
2527:15535124
2519:10543447
2480:10464316
2437:10226805
2387:Placenta
1926:10464316
1434:–
1413:–
1380:interact
1358:Function
1299:) is an
1262:Wikidata
939:Sources:
653:testicle
202:proteins
190:articles
178:articles
151:RCSB PDB
3353:Biology
3307:Ligases
3077:Enzymes
2963:Pronase
2953:Acrosin
2899:Chymase
2813:Plasmin
2645:Trypsin
2407:8761966
2378:8555184
2349:8280154
2320:8226803
2285:8025275
2250:7944388
2221:7686159
2186:3636155
2156:2551064
2127:1998666
2098:1993180
2055:1466300
1958:Bibcode
1885:7686159
1844:7944388
1776:Bibcode
1735:3521732
1700:9535413
1665:2534361
1624:2598771
1589:3237096
1548:6976185
1512:6918767
1436:Ensembl
1415:Ensembl
1072:UniProt
1027:Ensembl
966:Species
945:QuickGO
590:pattern
316:Aliases
138:profile
121:MetaCyc
44:CAS no.
3339:Portal
3281:Lyases
2990:Reelin
2932:Ancrod
2889:Other
2623:3.4.21
2577:(MeSH)
2554:
2525:
2517:
2499:
2478:
2443:
2435:
2405:
2376:
2347:
2318:
2283:
2248:
2219:
2184:
2154:
2125:
2096:
2053:
2043:
2019:694428
2017:
1990:291905
1988:
1981:413037
1978:
1924:
1883:
1842:
1808:291905
1806:
1799:413037
1796:
1733:
1698:
1663:
1622:
1587:
1577:
1546:
1510:
1500:
1319:- and
1301:enzyme
1248:search
1246:PubMed
1105:P26262
1086:P03952
982:Entrez
761:BioGPS
448:4q35.2
348:102849
340:229000
185:PubMed
167:Search
157:PDBsum
97:ExPASy
85:BRENDA
73:IntEnz
32:EC no.
3233:Types
2999:Furin
2946:Other
2873:MASP2
2868:MASP1
2798:KLK15
2793:KLK14
2788:KLK13
2783:KLK12
2778:KLK11
2773:KLK10
2523:S2CID
2441:S2CID
2263:Blood
1382:with
1337:KLKB1
1303:that
1015:16621
975:Mouse
970:Human
941:Amigo
641:gonad
613:Mouse
606:Human
553:Start
488:Mouse
452:Start
385:Human
364:KLKB1
356:68097
323:KLKB1
216:KLKB1
133:PRIAM
3422:2any
3407:2anw
3325:list
3318:EC7
3312:list
3305:EC6
3299:list
3292:EC5
3286:list
3279:EC4
3273:list
3266:EC3
3260:list
3253:EC2
3247:list
3240:EC1
3013:TPP1
2863:MASP
2768:KLK9
2763:KLK8
2758:KLK7
2753:KLK6
2748:KLK5
2743:KLK4
2738:KLK3
2733:KLK2
2728:KLK1
2552:PMID
2515:PMID
2476:PMID
2433:PMID
2403:PMID
2374:PMID
2345:PMID
2316:PMID
2281:PMID
2246:PMID
2217:PMID
2182:PMID
2152:PMID
2123:PMID
2094:PMID
2069:link
2051:PMID
2041:ISBN
2015:PMID
1986:PMID
1922:PMID
1881:PMID
1840:PMID
1804:PMID
1731:PMID
1696:PMID
1661:PMID
1620:PMID
1585:PMID
1575:ISBN
1544:PMID
1508:PMID
1498:ISBN
1341:gene
996:3818
731:nose
596:Bgee
544:Band
505:Chr.
443:Band
402:Chr.
336:OMIM
293:4ZJ6
289:4ZJ5
285:2ANY
281:4ZJ4
277:4OGX
273:2ANW
269:4OGY
250:RCSB
247:PDBe
197:NCBI
154:PDBe
109:KEGG
3003:S1P
2723:PSA
2544:doi
2507:doi
2493:380
2466:doi
2462:274
2425:doi
2395:doi
2366:doi
2337:doi
2333:197
2306:doi
2302:268
2271:doi
2238:doi
2234:314
2207:doi
2203:268
2174:doi
2144:doi
2115:doi
2086:doi
2033:doi
2007:doi
1976:PMC
1966:doi
1912:doi
1908:274
1871:doi
1867:268
1832:doi
1828:314
1794:PMC
1784:doi
1723:doi
1688:doi
1651:doi
1612:doi
1604:DNA
1567:doi
1536:doi
1490:doi
1321:Lys
1317:Arg
566:End
465:End
368:OMA
344:MGI
240:PDB
173:PMC
145:PDB
3441::
2620:EC
2614::
2550:.
2540:44
2538:.
2521:.
2513:.
2505:.
2491:.
2474:.
2460:.
2456:.
2439:.
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2389:.
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1422:^
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1386:.
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1294:EC
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572:bp
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366:;
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350:;
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