622:. PharmaMar requested a re-examination of the initial opinion. After a re-examination of the opinion, the refusal of the marketing authorization was confirmed in March 2018. The CHMP was of the opinion that the benefits of Aplidin did not outweigh its risks. Improvement in overall survival was not sufficiently demonstrated, and severe side effects were reported more frequently with the combination of Aplidin and dexamethasone than with dexamethasone alone. In October 2018, PharmaMar appealed against this decision, alleging a lack of impartiality on the part of certain members of the Scientific Advisory Group that had advised the CHMP. In October 2020, the General Court upheld PharmaMar's appeal and annulled the decision refusing marketing authorisation for Aplidin, and the European Commission then returned the application for Aplidin to the EMA.
121:
300:
323:
InChI=1S/C59H91N7O14/c1-15-35(8)50-47(69)30-49(71)80-53(34(6)7)52(72)37(10)54(73)60-41(26-32(2)3)58(77)65-24-16-18-42(65)48(70)31-63(12)44(29-39-20-22-40(79-14)23-21-39)46(68)28-36(9)51(56(75)61-50)62-55(74)45(27-33(4)5)64(13)59(78)43-19-17-25-66(43)57(76)38(11)67/h20-23,32-37,41-45,47,50-51,53,69H,15-19,24-31H2,1-14H3,(H,60,73)(H,61,75)(H,62,74)/t35-,36-,37-,41-,42-,43-,44-,45+,47-,50+,51-,53-/m0/s1
29:
2635:
450:
630:
In
Australia plitidepsin was approved in December 2018, in combination with dexamethasone, for the treatment of patients with relapsed and refractory multiple myeloma who have received at least three prior treatment regimens, including both a proteasome inhibitor and an immunomodulator. It may be
820:
419:
463:
574:
913:
615:
1613:
339:
806:
683:
347:
O=C((NC((C)C((OC(C(O)(NC((NC((N(C(1N(C(C(C)=O)=O)CCC1)=O)C)CC(C)C)=O)(C)OC((CC2=CC=C(OC)C=C2)N3C)=O)=O)(C)CC)=O)C(C)C)=O)=O)CC(C)C)N4(C3=O)CCC4
2589:
906:
2196:
2660:
1348:
1304:
1182:
1107:
314:
899:
712:
Adrio J, Cuevas C, Manzanares I, Joullié MM (July 2007). "Total synthesis and biological evaluation of tamandarin B analogues".
648:
Newman DJ, Cragg GM (August 2004). "Marine natural products and related compounds in clinical and advanced preclinical trials".
1829:
1623:
2242:
1244:
1134:
631:
used after two prior lines of therapy if refractory and/or intolerant to both a proteasome inhibitor and an immunomodulator.
2164:
2147:
2022:
1786:
1164:
821:"Public Summary of Positive Opinion for Orphan Designation of Aplidine for the Treatment of Acute Lymphoblastic Leukaemia"
2625:
470:
1896:
1492:
611:
257:
2606:
2098:
891:
278:
1278:
2464:
2344:
2334:
607:
618:(CHMP) adopted a negative opinion, recommending the refusal of the marketing authorization for the treatment of
2516:
2449:
2419:
2037:
1287:
54:--11-hydroxy-3--2,6,17-trimethyl-20-(2-methylpropyl)-1,4,8,13,16,18,21-heptaoxo-15-(propan-2-yl)docosahydro-15
2594:
2501:
2319:
2034:
1520:
1368:
1295:
2655:
2399:
2389:
2122:
1964:
161:
1671:
1488:
1458:
1318:
800:
677:
570:
activities. It shows promise in shrinking tumors in pancreatic, stomach, bladder, and prostate cancers.
508:. It is currently undergoing clinical trial testing. It is a member of the class of compounds known as
41:
2069:
1946:
1467:
1383:
760:
749:"Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A"
2354:
2254:
2233:
1954:
1776:
1608:
1339:
1235:
295:
87:
1412:
2561:
535:
bond in place of one or more of a peptide bond. Its chemical structure is very close to that of
1442:
1422:
1407:
2536:
2110:
944:
788:
729:
665:
567:
498:
181:
2541:
2298:
2013:
1647:
1632:
1353:
837:
778:
768:
721:
657:
619:
362:
97:
266:
2639:
1980:
1942:
1733:
1155:
1070:
525:
747:
White KM, Rosales R, Yildiz S, Kehrer T, Miorin L, Moreno E, et al. (January 2021).
299:
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1969:
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1848:
1662:
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1117:
931:
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521:
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2566:
2546:
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2511:
2439:
2379:
2349:
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2139:
2080:
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2042:
1995:
1959:
1875:
1837:
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1814:
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1771:
1742:
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1700:
1690:
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1506:
1392:
1323:
1309:
1264:
1197:
1192:
1169:
1144:
1112:
1055:
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980:
975:
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603:
578:
540:
2556:
2459:
2454:
2429:
2424:
2414:
2409:
2404:
2374:
2364:
2329:
2324:
2304:
2259:
2247:
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2217:
2207:
2189:
2184:
2174:
2169:
2127:
2115:
2103:
2075:
2062:
2057:
2027:
1990:
1985:
1923:
1918:
1864:
1809:
1761:
1747:
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1682:
1651:
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1038:
990:
586:
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502:
396:
172:
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2551:
2506:
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1975:
1913:
1854:
1843:
1799:
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1715:
1709:
1705:
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1579:
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1511:
1472:
1447:
1437:
1397:
1043:
1033:
1028:
1023:
985:
773:
582:
544:
490:
792:
733:
669:
2480:
2444:
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2090:
1870:
1766:
1738:
1417:
1254:
547:
509:
192:
201:
1373:
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1088:
949:
851:
528:
233:
725:
661:
1013:
152:
440:
Except where otherwise noted, data are given for materials in their
28:
221:
58:-pyrrolo dioxatetraazacyclotricosin-7-yl}carbamoyl)-3-methylbutyl]-
532:
132:
120:
110:
212:
895:
283:
701:(4th ed.). United States: Brooks/Cole. p. 98.
458:
2623:
826:. European Medicines Agency (EMA). 1 September 2011.
2281:
2232:
2012:
2005:
1941:
1895:
1828:
1785:
1622:
1607:
1487:
1457:
1382:
1367:
1338:
1234:
1154:
1097:
1080:
1069:
1005:
958:
939:
62:-methyl-1-(2-oxopropanoyl)pyrrolidine-2-carboxamide
558:Like all didemnin compounds, plitidepsin exhibits
245:
577:which has potential interactions with multiple
96:
616:Committee for Medicinal Products for Human Use
907:
699:Oceanography: An Invitation to Marine Science
8:
2009:
1619:
1379:
1094:
1077:
955:
914:
900:
892:
298:
180:
20:
782:
772:
265:
589:in vitro and in an in vivo mouse model.
543:residue in didemnin B is present in the
2630:
640:
573:Plitidepsin inhibits the human protein
344:
319:
294:
200:
798:
675:
602:In July 2003, plitidepsin was granted
71:Aplidine; Dehydrodidemnin B; Aplidin;
539:, the only difference being that the
326:Key: RZFJKZZAZSUBCF-VETSTYKFSA-N
160:
140:
7:
429:
1183:ribonucleotide reductase inhibitors
882:Australian Public Assessment Report
236:
220:
1349:Ribonucleotide reductase inhibitor
1305:Ribonucleotide reductase inhibitor
840:. European Medicines Agency (EMA).
805:: CS1 maint: overridden setting (
682:: CS1 maint: overridden setting (
14:
1108:Dihydrofolate reductase inhibitor
2633:
714:The Journal of Organic Chemistry
581:proteins. Plitidepsin possesses
448:
380:
374:
27:
444:(at 25 °C , 100 kPa).
1245:Thymidylate synthase inhibitor
1135:Thymidylate synthase inhibitor
614:. In December 2017, the EMA's
593:Marketing authorisation status
531:in which there is one or more
386:
368:
1:
1165:Adenosine deaminase inhibitor
1006:Block microtubule disassembly
612:acute lymphoblastic leukemia
493:, S.A. under the trade name
650:Journal of Natural Products
2677:
2661:Experimental cancer drugs
2584:
2465:Omacetaxine mepesuccinate
2345:Ciltacabtagene autoleucel
2335:Brexucabtagene autoleucel
856:European Medicines Agency
608:European Medicines Agency
438:
412:
355:
335:
310:
80:
68:
40:
35:
26:
2517:Talimogene laherparepvec
2450:Nadofaragene firadenovec
2420:Lisocabtagene maraleucel
1369:Topoisomerase inhibitors
1288:DNA polymerase inhibitor
554:Pharmacological activity
520:Plitidepsin is a cyclic
2320:Axicabtagene ciloleucel
924:chemotherapeutic agents
774:10.1126/science.abf4058
2502:Sitimagene ceradenovec
2400:Idecabtagene vicleucel
1965:Methyl aminolevulinate
1976:Porphyrin derivatives
1672:Melphalan flufenamide
1319:Hypomethylating agent
928:antineoplastic agents
878:"AusPAR: Plitidepsin"
42:Systematic IUPAC name
2305:Asparagine depleters
2234:Receptor antagonists
2148:+abiraterone acetate
2355:Denileukin diftitox
2255:Retinoid X receptor
1955:Aminolevulinic acid
1777:Triethylenemelamine
1609:Crosslinking of DNA
1340:Deoxyribonucleotide
1279:+gimeracil/oteracil
765:2021Sci...371..926W
697:Garrison T (2002).
501:extracted from the
408: g·mol
23:
2611:Never to phase III
1413:Etirinotecan pegol
524:, meaning it is a
516:Chemical structure
471:Infobox references
21:
2621:
2620:
2580:
2579:
2537:Tigilanol tiglate
2014:Enzyme inhibitors
1937:
1936:
1933:
1932:
1633:Nitrogen mustards
1603:
1602:
1363:
1362:
1065:
1064:
858:. 28 October 2020
759:(6532): 926–931.
726:10.1021/jo070412r
662:10.1021/np040031y
585:activity against
568:immunosuppressive
506:Aplidium albicans
499:chemical compound
487:dehydrodidemnin B
479:Chemical compound
477:
476:
279:CompTox Dashboard
122:Interactive image
16:Chemical compound
2668:
2638:
2637:
2636:
2629:
2542:Tisagenlecleucel
2299:Arsenic trioxide
2010:
1943:Photosensitizers
1734:Alkyl sulfonates
1648:Cyclophosphamide
1620:
1559:Anthracenediones
1380:
1354:Hydroxycarbamide
1095:
1078:
956:
916:
909:
902:
893:
886:
885:
874:
868:
867:
865:
863:
848:
842:
841:
834:
828:
827:
825:
817:
811:
810:
804:
796:
786:
776:
744:
738:
737:
709:
703:
702:
694:
688:
687:
681:
673:
645:
620:multiple myeloma
461:
455:
452:
451:
433:
407:
405:
388:
382:
376:
370:
363:Chemical formula
303:
302:
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100:
31:
24:
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2646:
2645:
2644:
2634:
2632:
2624:
2622:
2617:
2616:
2601:Clinical trials
2576:
2282:Other/ungrouped
2277:
2228:
2001:
1981:Porfimer sodium
1929:
1891:
1824:
1781:
1611:
1599:
1483:
1453:
1371:
1359:
1334:
1230:
1150:
1086:
1084:antimetabolites
1082:
1081:DNA precursors/
1073:
1071:DNA replication
1061:
1001:
971:Vinca alkaloids
947:
935:
920:
890:
889:
876:
875:
871:
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859:
850:
849:
845:
836:
835:
831:
823:
819:
818:
814:
797:
746:
745:
741:
720:(14): 5129–38.
711:
710:
706:
696:
695:
691:
674:
647:
646:
642:
637:
628:
600:
595:
556:
518:
485:(also known as
480:
473:
468:
467:
466: ?)
457:
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5:
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2332:
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2322:
2317:
2301:
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2283:
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2263:
2251:
2238:
2236:
2230:
2229:
2227:
2226:
2220:
2215:
2210:
2205:
2193:
2187:
2182:
2177:
2172:
2161:
2155:
2150:
2142:
2135:PARP inhibitor
2131:
2119:
2107:
2095:
2094:
2093:
2088:
2083:
2078:
2066:
2060:
2055:
2050:
2045:
2031:
2018:
2016:
2007:
2003:
2002:
2000:
1999:
1993:
1988:
1983:
1972:
1967:
1962:
1957:
1951:
1949:
1939:
1938:
1935:
1934:
1931:
1930:
1928:
1927:
1921:
1916:
1911:
1901:
1899:
1893:
1892:
1890:
1889:
1883:
1878:
1867:
1862:
1857:
1852:
1840:
1834:
1832:
1826:
1825:
1823:
1822:
1817:
1812:
1807:
1802:
1797:
1791:
1789:
1787:Platinum-based
1783:
1782:
1780:
1779:
1774:
1769:
1764:
1752:
1751:
1745:
1729:
1728:
1723:
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1703:
1698:
1686:
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1680:
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1660:
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1600:
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1597:
1592:
1587:
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1577:
1571:
1566:
1555:
1549:
1544:
1539:
1534:
1529:
1524:
1514:
1509:
1502:Anthracyclines
1497:
1495:
1485:
1484:
1482:
1481:
1475:
1463:
1461:
1455:
1454:
1452:
1451:
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1420:
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1405:
1400:
1388:
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1377:
1365:
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1360:
1358:
1357:
1344:
1342:
1336:
1335:
1333:
1332:
1326:
1314:
1313:
1300:
1299:
1283:
1282:
1272:
1267:
1262:
1257:
1252:
1240:
1238:
1232:
1231:
1229:
1228:
1222:
1220:Mercaptopurine
1211:
1206:
1201:
1195:
1190:
1174:
1173:
1160:
1158:
1152:
1151:
1149:
1148:
1142:
1131:
1125:
1120:
1115:
1103:
1101:
1092:
1075:
1067:
1066:
1063:
1062:
1060:
1059:
1047:
1041:
1036:
1031:
1026:
1021:
1009:
1007:
1003:
1002:
1000:
999:
993:
988:
983:
978:
966:
964:
953:
937:
936:
922:Intracellular
921:
919:
918:
911:
904:
896:
888:
887:
884:. 8 July 2019.
869:
843:
829:
812:
739:
704:
689:
656:(8): 1216–38.
639:
638:
636:
633:
627:
624:
606:status by the
599:
598:European Union
596:
594:
591:
555:
552:
517:
514:
489:, marketed by
478:
475:
474:
469:
447:
446:
442:standard state
439:
436:
435:
423:
418:
415:
414:
410:
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399:
393:
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389:
383:
377:
371:
366:
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289:
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185:
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149:
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137:
135:
129:
128:
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117:
115:
108:
105:
104:
102:
101:
93:
91:
86:
83:
82:
78:
77:
70:
66:
65:
45:
44:
38:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
2673:
2662:
2659:
2657:
2656:Depsipeptides
2654:
2653:
2651:
2641:
2631:
2627:
2610:
2608:
2605:
2604:
2602:
2599:
2596:
2593:
2591:
2588:
2587:
2583:
2573:
2570:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2550:
2548:
2545:
2543:
2540:
2538:
2535:
2533:
2530:
2528:
2525:
2523:
2520:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2495:
2492:
2489:
2487:
2483:
2482:
2478:
2476:
2475:Tabelecleucel
2473:
2471:
2468:
2466:
2463:
2461:
2458:
2456:
2453:
2451:
2448:
2446:
2443:
2441:
2438:
2436:
2435:Lurbinectedin
2433:
2431:
2428:
2426:
2423:
2421:
2418:
2416:
2413:
2411:
2408:
2406:
2403:
2401:
2398:
2396:
2393:
2391:
2388:
2386:
2383:
2381:
2378:
2376:
2373:
2371:
2368:
2366:
2363:
2361:
2358:
2356:
2353:
2351:
2348:
2346:
2343:
2341:
2338:
2336:
2333:
2331:
2328:
2326:
2323:
2321:
2318:
2315:
2311:
2307:
2306:
2302:
2300:
2297:
2295:
2292:
2290:
2287:
2286:
2284:
2280:
2273:
2269:
2268:
2264:
2261:
2257:
2256:
2252:
2249:
2245:
2244:
2240:
2239:
2237:
2235:
2231:
2224:
2221:
2219:
2216:
2214:
2211:
2209:
2206:
2204:
2200:
2198:
2194:
2191:
2188:
2186:
2183:
2181:
2178:
2176:
2173:
2171:
2167:
2166:
2162:
2159:
2156:
2154:
2151:
2149:
2146:
2143:
2141:
2137:
2136:
2132:
2129:
2125:
2124:
2120:
2117:
2113:
2112:
2108:
2105:
2101:
2100:
2096:
2092:
2089:
2087:
2084:
2082:
2079:
2077:
2074:
2073:
2072:
2071:
2067:
2064:
2061:
2059:
2056:
2054:
2051:
2049:
2046:
2044:
2040:
2039:
2036:
2032:
2029:
2025:
2024:
2020:
2019:
2017:
2015:
2011:
2008:
2004:
1997:
1994:
1992:
1989:
1987:
1984:
1982:
1978:
1977:
1973:
1971:
1968:
1966:
1963:
1961:
1958:
1956:
1953:
1952:
1950:
1948:
1944:
1940:
1925:
1922:
1920:
1917:
1915:
1912:
1910:
1906:
1903:
1902:
1900:
1898:
1897:Intercalation
1894:
1887:
1884:
1882:
1879:
1877:
1873:
1872:
1868:
1866:
1863:
1861:
1858:
1856:
1853:
1850:
1846:
1845:
1841:
1839:
1836:
1835:
1833:
1831:
1827:
1821:
1818:
1816:
1813:
1811:
1808:
1806:
1805:Dicycloplatin
1803:
1801:
1798:
1796:
1793:
1792:
1790:
1788:
1784:
1778:
1775:
1773:
1770:
1768:
1765:
1763:
1760:
1758:
1754:
1753:
1749:
1746:
1744:
1740:
1737:
1735:
1731:
1730:
1727:
1724:
1722:
1719:
1717:
1714:
1711:
1707:
1704:
1702:
1699:
1697:
1694:
1692:
1688:
1687:
1684:
1681:
1679:
1678:Prednimustine
1676:
1673:
1669:
1666:
1664:
1661:
1658:
1655:
1653:
1649:
1646:
1644:
1641:
1639:
1636:
1634:
1630:
1629:
1627:
1625:
1621:
1618:
1615:
1610:
1606:
1596:
1593:
1591:
1588:
1586:
1583:
1581:
1578:
1575:
1572:
1570:
1567:
1565:
1561:
1560:
1556:
1553:
1550:
1548:
1545:
1543:
1540:
1538:
1535:
1533:
1530:
1528:
1525:
1522:
1518:
1515:
1513:
1510:
1508:
1504:
1503:
1499:
1498:
1496:
1494:
1493:Intercalation
1490:
1486:
1479:
1476:
1474:
1470:
1469:
1465:
1464:
1462:
1460:
1456:
1449:
1446:
1444:
1441:
1439:
1436:
1434:
1431:
1429:
1426:
1424:
1421:
1419:
1416:
1414:
1411:
1409:
1406:
1404:
1401:
1399:
1395:
1394:
1390:
1389:
1387:
1385:
1381:
1378:
1375:
1370:
1366:
1355:
1351:
1350:
1346:
1345:
1343:
1341:
1337:
1330:
1327:
1325:
1321:
1320:
1316:
1315:
1311:
1307:
1306:
1302:
1301:
1297:
1296:+daunorubicin
1294:
1290:
1289:
1285:
1284:
1280:
1276:
1273:
1271:
1268:
1266:
1263:
1261:
1260:Doxifluridine
1258:
1256:
1253:
1251:
1247:
1246:
1242:
1241:
1239:
1237:
1233:
1226:
1223:
1221:
1217:
1216:
1212:
1210:
1209:Rabacfosadine
1207:
1205:
1202:
1199:
1196:
1194:
1191:
1189:
1185:
1184:
1180:
1176:
1175:
1171:
1167:
1166:
1162:
1161:
1159:
1157:
1153:
1146:
1143:
1141:
1137:
1136:
1132:
1129:
1126:
1124:
1121:
1119:
1116:
1114:
1110:
1109:
1105:
1104:
1102:
1100:
1096:
1093:
1090:
1085:
1079:
1076:
1072:
1068:
1057:
1053:
1052:
1048:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1016:
1015:
1011:
1010:
1008:
1004:
997:
994:
992:
989:
987:
984:
982:
979:
977:
973:
972:
968:
967:
965:
962:
957:
954:
951:
946:
942:
938:
933:
929:
925:
917:
912:
910:
905:
903:
898:
897:
894:
883:
879:
873:
870:
857:
853:
847:
844:
839:
833:
830:
822:
816:
813:
808:
802:
794:
790:
785:
780:
775:
770:
766:
762:
758:
754:
750:
743:
740:
735:
731:
727:
723:
719:
715:
708:
705:
700:
693:
690:
685:
679:
671:
667:
663:
659:
655:
651:
644:
641:
634:
632:
625:
623:
621:
617:
613:
610:for treating
609:
605:
597:
592:
590:
588:
584:
580:
576:
571:
569:
565:
561:
553:
551:
549:
546:
542:
538:
534:
530:
527:
523:
515:
513:
511:
507:
504:
500:
496:
492:
488:
484:
472:
465:
460:
443:
437:
432:
427:
424:
421:
417:
416:
413:Pharmacology
411:
400:
398:
395:
394:
367:
364:
360:
359:
354:
345:
341:
334:
320:
316:
309:
301:
297:
296:DTXSID0040418
293:
292:
290:
280:
276:
275:
268:
264:
263:
261:
259:
256:
255:
248:
244:
243:
241:
235:
231:
230:
223:
219:
218:
216:
214:
211:
210:
203:
199:
198:
196:
194:
191:
190:
183:
179:
178:
176:
174:
171:
170:
163:
159:
158:
156:
154:
151:
150:
143:
139:
138:
136:
134:
131:
130:
123:
119:
118:
116:
112:
107:
106:
99:
95:
94:
92:
89:
85:
84:
79:
74:
67:
61:
57:
53:
49:
43:
39:
34:
30:
25:
19:
2522:Tazemetostat
2486:Alitretinoin
2479:
2469:
2390:Estramustine
2370:Elsamitrucin
2360:Eflornithine
2314:Pegaspargase
2310:Asparaginase
2303:
2272:Testolactone
2265:
2253:
2241:
2195:
2180:Panobinostat
2163:
2133:
2121:
2109:
2097:
2068:
2033:
2021:
1974:
1970:Padeliporfin
1909:Dactinomycin
1905:Streptomyces
1886:Temozolomide
1881:Mitozolomide
1869:
1860:Mitobronitol
1849:Procarbazine
1842:
1830:Nonclassical
1755:
1732:
1726:Streptozocin
1691:Nitrosoureas
1689:
1663:Chlorambucil
1657:Trofosfamide
1643:Chlormethine
1638:Bendamustine
1631:
1569:Mitoxantrone
1564:Losoxantrone
1557:
1517:Daunorubicin
1500:
1466:
1403:Camptothecin
1391:
1347:
1317:
1303:
1286:
1270:Fluorouracil
1250:Capecitabine
1243:
1213:
1177:
1163:
1133:
1128:Pralatrexate
1118:Methotrexate
1106:
1049:
1012:
969:
881:
872:
860:. Retrieved
855:
846:
832:
815:
801:cite journal
756:
752:
742:
717:
713:
707:
698:
692:
678:cite journal
653:
649:
643:
629:
601:
572:
557:
522:depsipeptide
519:
505:
494:
486:
482:
481:
162:ChEMBL451930
81:Identifiers
72:
69:Other names
59:
55:
51:
47:
22:Plitidepsin
18:
2597:from market
2567:Vorasidenib
2547:Trabectedin
2532:Tiazofurine
2527:Tebentafusp
2512:Tagraxofusp
2470:Plitidepsin
2440:Mitoguazone
2380:Epacadostat
2350:Demecolcine
2294:Aflibercept
2267:Sex steroid
2140:Fuzuloparib
2081:Carfilzomib
2053:Palbociclib
2043:Abemaciclib
1996:Verteporfin
1960:Efaproxiral
1876:Dacarbazine
1838:Altretamine
1820:Satraplatin
1815:Oxaliplatin
1795:Carboplatin
1772:Triaziquone
1743:Mannosulfan
1721:Ranimustine
1701:Fotemustine
1542:Pirarubicin
1527:Doxorubicin
1521:+cytarabine
1507:Aclarubicin
1468:Podophyllum
1393:Camptotheca
1324:Azacitidine
1310:Gemcitabine
1265:Floxuridine
1198:Fludarabine
1193:Clofarabine
1179:Halogenated
1170:Pentostatin
1145:Raltitrexed
1113:Aminopterin
1056:Ixabepilone
1051:Epothilones
1019:Cabazitaxel
996:Vinorelbine
981:Vincristine
976:Vinblastine
961:microtubule
604:orphan drug
579:coronavirus
483:Plitidepsin
356:Properties
142:CHEBI:90205
98:137219-37-5
75:-didemnin A
2650:Categories
2562:Verdinexor
2557:Venetoclax
2460:Oblimersen
2455:Navitoclax
2430:Lucanthone
2425:Lonidamine
2415:Lifileucel
2410:Ivosidenib
2405:Imetelstat
2375:Enasidenib
2365:Elesclomol
2330:Bexarotene
2325:Belzutifan
2260:Bexarotene
2248:Atrasentan
2223:Umbralisib
2218:Idelalisib
2208:Copanlisib
2190:Vorinostat
2185:Romidepsin
2175:Entinostat
2170:Belinostat
2128:Masoprocol
2116:Tiazofurin
2104:Anagrelide
2076:Bortezomib
2063:Seliciclib
2058:Ribociclib
2038:inhibitors
2028:Tipifarnib
1991:Temoporfin
1986:Talaporfin
1924:Plicamycin
1919:Mitomycins
1865:Pipobroman
1844:Hydrazines
1810:Nedaplatin
1762:Carboquone
1757:Aziridines
1748:Treosulfan
1696:Carmustine
1683:Uramustine
1652:Ifosfamide
1624:Alkylating
1585:Bisantrene
1574:Pixantrone
1547:Valrubicin
1537:Idarubicin
1532:Epirubicin
1478:Teniposide
1433:Lurtotecan
1428:Irinotecan
1329:Decitabine
1293:Cytarabine
1236:Pyrimidine
1225:Tioguanine
1215:Thiopurine
1204:Nelarabine
1188:Cladribine
1140:Pemetrexed
1123:Pemetrexed
1099:Folic acid
1039:Paclitaxel
991:Vinflunine
635:References
587:SARS-CoV-2
537:didemnin B
397:Molar mass
267:Y76ID234HW
173:ChemSpider
109:3D model (
88:CAS Number
2607:Phase III
2595:Withdrawn
2572:Vosaroxin
2552:Veliparib
2507:Sotorasib
2497:Selinexor
2491:Tretinoin
2481:Retinoids
2395:Glasdegib
2340:Celecoxib
2289:Adagrasib
2213:Duvelisib
2203:Alpelisib
2158:Rucaparib
2145:Niraparib
2086:Oprozomib
2048:Alvocidib
1914:Bleomycin
1871:Triazenes
1855:Etoglucid
1800:Cisplatin
1716:Nimustine
1710:Semustine
1706:Lomustine
1668:Melphalan
1595:Menogaril
1590:Crisnatol
1580:Amsacrine
1552:Zorubicin
1512:Amrubicin
1473:Etoposide
1448:Topotecan
1443:Silatecan
1438:Rubitecan
1423:Gimatecan
1408:Cositecan
1398:Belotecan
1074:inhibitor
1044:Tesetaxel
1034:Ortataxel
1029:Larotaxel
1024:Docetaxel
986:Vindesine
852:"Aplidin"
838:"Aplidin"
626:Australia
583:antiviral
564:antiviral
560:antitumor
550:version.
510:didemnins
491:PharmaMar
2640:Medicine
2445:Mitotane
2385:Eribulin
2153:Olaparib
2091:Ixazomib
1767:Thiotepa
1739:Busulfan
1418:Exatecan
1255:Carmofur
963:assembly
926: /
793:33495306
734:17555353
670:15332835
548:pyruvate
545:oxidized
503:ascidian
434:)
420:ATC code
193:DrugBank
182:26001665
1374:S phase
1275:Tegafur
1089:S phase
1014:Taxanes
950:M phase
862:11 July
784:7963220
761:Bibcode
753:Science
541:lactate
529:peptide
497:) is a
495:Aplidin
464:what is
462: (
428: (
426:L01XX57
247:9812534
234:PubChem
202:DB04977
2626:Portal
2590:WHO-EM
2199:(Pi3K)
1156:Purine
959:Block
791:
781:
732:
668:
526:cyclic
459:verify
456:
340:SMILES
222:D11032
153:ChEMBL
36:Names
2111:IMPDI
2006:Other
824:(PDF)
575:eEF1A
533:ester
315:InChI
133:ChEBI
111:JSmol
2197:PIKI
2165:HDAC
1614:CCNS
864:2024
807:link
789:PMID
730:PMID
684:link
666:PMID
566:and
406:.357
258:UNII
213:KEGG
2243:ERA
2099:PhI
2070:PrI
2035:CDK
1947:PDT
945:MIs
941:SPs
932:L01
779:PMC
769:doi
757:371
722:doi
658:doi
431:WHO
404:110
284:EPA
237:CID
2652::
2603::
2123:LI
2023:FI
1489:II
1459:II
1281:))
880:.
854:.
803:}}
799:{{
787:.
777:.
767:.
755:.
751:.
728:.
718:72
716:.
680:}}
676:{{
664:.
654:67
652:.
562:,
512:.
390:15
378:87
372:57
50:)-
46:(2
2628::
2493:)
2484:(
2316:)
2312:/
2308:(
2274:)
2270:(
2262:)
2258:(
2250:)
2246:(
2225:)
2201:(
2192:)
2168:(
2160:)
2138:(
2130:)
2126:(
2118:)
2114:(
2106:)
2102:(
2065:)
2041:(
2030:)
2026:(
1998:)
1979:(
1945:/
1926:)
1907:(
1888:)
1874:(
1851:)
1847:(
1759::
1750:)
1741:(
1736::
1712:)
1708:(
1693::
1674:)
1670:(
1659:)
1650:(
1635::
1616:)
1612:(
1576:)
1562:(
1554:)
1523:)
1519:(
1505:(
1491:+
1480:)
1471:(
1450:)
1396:(
1384:I
1376:)
1372:(
1356:)
1352:(
1331:)
1322:(
1312:)
1308:(
1298:)
1291:(
1277:(
1248:(
1227:)
1218:(
1200:)
1186:(
1181:/
1172:)
1168:(
1147:)
1138:(
1130:)
1111:(
1091:)
1087:(
1058:)
1054:(
1046:)
1017:(
998:)
974:(
952:)
948:(
943:/
934:)
930:(
915:e
908:t
901:v
866:.
809:)
795:.
771::
763::
736:.
724::
686:)
672:.
660::
454:Y
402:1
387:O
384:7
381:N
375:H
369:C
286:)
282:(
113:)
73:N
60:N
56:H
52:N
48:S
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